Peptide Cancer Claims Debunked | 20+ Studies Analyzed

0:00 Hey everybody, this is Hunter Williams. I hope you're doing amazing wherever you are at in the world today.I have a video that I think is going to be really fun and it's going be about the peptides that actually have anti-cancer evidence. And so today I want to preface this, even though I do in most of my videos, This is not medical advice. You should probably never use peptide because there's not a lot of human evidence, right? And anything I say is just for educational and entertainment purposes. But one thing, I guess, for lack of a better way to say it, that really grinds my gears is that there's all this stuff in the peptide social media landscape

0:37 now about how peptides cause cancer. And I think one of the easiest ways, especially in an alternative health world, to discredit something or to basically give it, uh, not what it's do is just say, oh, that causes cancer. Oh, theoretically that cause cancer because immediately people are really afraid of two things. They're one afraid dying and cancer, well, I guess they'd be afraid have cancer that then causes them to die, but there's one healthier that people have. It's getting cancer and so if you just, say this gives you cancer you're immediately going to turn a lot of people off from ever using it and just not

1:12 having it in their weapon repertoire. And I'm kind of divided on this because in one way we don't necessarily know definitively, but then there's also the question of like, what do we actually know definitely? Just from a philosophical perspective, like you don' know if you wake up today, if it's going to be your last day or something that could happen to you. So there is always a risk with everything. And so I guess one thing I get annoyed with is when people say things that are kind just like these gross generalizations,

1:45 to scare people away that aren't backed in really anything other than theory. And what I want to do today is actually review peptides and obviously I have a biased lens, right? I'm a supporter of peptide. I've seen them firsthand do amazing things in people's lives and I get messages every single day about how amazing a certain peptide stack has done in someone's life and how it's created so much change and helped them so, much and turn their life around. And so I guess I'm a little bit biased, but what I want to do today is like, okay, we have all of these people that make short form social media content,

2:17 because I really don't see any long form, social, media, content flushing this out. but they make short form social media content and they just say peptides cause cancer and a bunch of people get scared and fight in the comments and stuff and so I don't play that game but the game I do play is doing long form deep dive videos and what I'm going to do today is just take individual peptide and look at published clinical literature that shows that they actually have direct anti-cancer evidence. And so obviously this is going to be a little bit biased.

2:47 You could probably go find some things that may be pro- cancer. I think there's much more in the anti cancer than the pro cancer camp, but you could go and do that. But what I want to do today is just say, hey, for all of the people out there that are talking about this, let's look at some peptides and what they actually do if we can find a study. The problem is there's not a lot of studies on peptides, let alone looking at cancer, but there are some out there. And so that's what I'm going to do today is I spent some time compiling as much as I could around some of the more common peptide that we all love and

3:18 use and what they actually say about cancer. So for every person that sends you or creates a 60 second clip saying that peptids cause cancer Maybe send them this video and it's probably, I don't know how long this will end up being, but send this to them because I think it will be helpful to actually look at the evidence and what I will do, in this description I'll have my editors do it to put a link to all the studies. I've got the links here on the slides. We'll put the link in the description so you can just go read for yourself. At the end of the day, it doesn't matter to me what you do.

3:48 You can use peptides, you cannot use them. but I hope that through my content, you will become more of an informed consumer. So that's what we're gonna talk about today. As always, make sure you're on the email list. Hey, I'm talking about the C word in this video today, so maybe it gets banned or shut down. Hopefully it doesn't, but all I am doing is looking at published studies. I not saying one way or the other whether you should use peptides. That being said, censorship is on the rise as always. So make sure you're on an email list. You can click that. I have now one link where you can sign up for everything. It just takes you to a page as you going to see all the different things on there instead of having a bunch of different links,

4:20 which is really nice. And obviously, if you want to talk directly to me and make you have your question answered, the best way is to join my private group. it's called the Accion Collective. We have live coaching calls. so you could talk with me live on those group coaching call or you message me privately or chat in the forum. That's the way to get in touch with if would like to do so. Alright, without further ado, I'm going to share my screen and today we're going look at some studies that show peptides have direct anti-cancer evidence. Alright let's get into it. Let's look into some of these peptide with anti direct cancer evidence First one, and I've just got these in alphabetical order,

4:53 first one is going be AOD9604. So we've also got HGHFRAG176191. These are kind of like sister peptids. I believe, just quoting off of memory, Aod has a tyrosine modification to it to enhance it slightly. And so if you watch my recent video about which peptides I think are kind of worthless, these are two of them. However, what is interesting is that we do have some cancer evidence around them, which is kind ironic because these fragments of human growth hormone, everyone is afraid of when it comes to cancer.

5:23 But anyway, let's look at this. So there was a study in 2022 that looked at AOD and HGH frag 176191. And basically what they did is they loaded nanoparticles with the peptide, and they were tested in MCF7 breast cancer cells. So this was in vitro, not in vivo. But adding the peptide increased doxorubicin toxicity, dropping from ICF50 from 1.85 to 1,5. The peptid-only nanопarticle did not kill cells,

5:54 it acted as a chemosensitizer, but not a standalone agent. So again, what's interesting is that this worked as a chemo sensitizer, which you would think would be the opposite, because if it's a fragment of human growth hormone, you'd think that it is actually increasing cancer. But in this case, it actually acted as chemosensitizer. So, not killing the cancer cells directly, but enhancing the cancers therapy, Which is something thymus and alpha 1, we'll talk a little bit later, thimus alpha one does really well, But I thought that was interesting in that one, especially considering it was a growth hormonal peptide.

6:25 Ah, the lovely BPC 157. Well, because this is the most popular peptide, it is also the one that people love to hate and say that it causes cancer. Now, again, we don't have a lot of published human data on this, so take everything with a caveat, but let's look at two studies. So we have 2004 study that looked at melanoma research. In vitro, Bpc157 inhibited, which means basically stopped, inhibiting human melanoma cell growth and reduced VEGF and MAPK signaling.

6:56 Again, this was a conference abstract. It was not replicated, but a 2025 pharmaceutical review especially notes no published in vivo data show tumor inhibition, But it did inhibit human melanoma, cell-growth in this 2004 paper. So again, take that for what it's worth. But, it'd interesting you would think that if it is causing cancer that it would exacerbate, not inhibit, melanomal cell grow. This one's a little bit better. So we had a 2018 study in C26 colon cancer, cachexia mice, BPC 157 counteracted muscle wasting, which happens during cancer.

7:33 It reduced TNF alpha and interleukin 6. and prolonged survival. So there was no tumor shrinkage observed. However, this is a supportive care effect. Again, these animals were, they were not induced with cancer via the BPC-157. They already had cancer and then they treated them with Bpc- 157 and it prolonged the survival, so it did not make the tumors worse and did also prolong survival and so again, we would think okay Bbc 15 7 causes cancer, it would make cancer worse these instances and it actually did the opposite.

8:06 So again, we can't say that it eliminated tumors, but it enhanced the health of the rodents to the point that a prolonged survival and the ones that took BPC 157 with cancer survived longer than the one's that did not. Can we extrapolate that to humans? No, there's obviously differences between humans and rodent, But that's the closest thing that we have around Bpc 15 7 as it relates to cancer. Take those with a grain of salt as you will, but this is real data that we have on it rather than just saying on a podcast clip, hey, BPC-157 causes cancer, stay away from it.

8:38 All right, let's look at DCIP. This is pretty cool. So DCP is Delta Sleep Inducing Peptide. We have a 2003 study that looked at mechanisms of aging and development. So, female SHR mice injected monthly with DCEP from age 3 months until death. Dcep cuts spontaneous tumor incidence 2.6-fold versus controls, mainly mammary tumors and leukemias. So the maximum lifespan was extended 24% for the animals injected with bone marrow chromosome aberrations were reduced by 22.6%. And the reason that we

9:12 think this is because it's an antioxidant and it works on pineal axis restoration, which obviously enhances a ton of things, including melatonin production, Looking at DCIP, does it eliminate tumors or prevent the creation of spontaneous tumors in humans? We don't know, but we do have direct evidence that it reduced the average rate of tumor incidence in mice and it had all these positive benefits for life extension and everything in my mice. And so mechanistically speaking, when you say, wow, DCEP looks pretty good as it relates to that.

9:46 Now, it doesn't mean that's going to cure cancer. We dont know. But again, very good evidence to support that its good. Epitalon, this is actually one that a lot of people say like, oh, you have to be careful that mechanistically it could cause cancer. Well, let's look at the data. 2003 study, lifelong dosing in mice, leukemia developed reduced sixfold to the mice that were given epitalin during their life. bone marrow chromosome aberrations were down 17% and the total tumor incidence was unchanged. So at the very least, we know that it did not increase the rate of tumors and it also reduced the rates of leukemia in the epitalon mice versus the control mice,

10:24 which is pretty interesting. A 2002 study looked at HER2-NEU transgenic mice and it reduced the tumor number. There were smaller tumors and then the mRNA expression of those tumors were down 3.7 fold. Lung metastasis size was also reduced with epitalin. So very interesting there. Another 2002 study, DMH colon carcinogenesis in rats, colon tumors per rat drop from around 4.1 to 2.7. Tumors also were smaller and reductions were seen

10:56 in dejunum and ileum. So again, when we look at this epitalon, we do have evidence suggests that not only is it not pro cancer, but it's actually reducing the incidence of cancer and then also reducing tumor size. Again, does this mean it will cause it in humans? We don't know, But there's evidence to show that it does those things. Folistatin 344, this is pretty interesting. So again, when we look at folistatin, you have it delivered via a subcutaneous injection and also delivered the gene therapy.

11:26 And so this incidence looked at gene-therapy, folostatin delivered into mice, so lipid nanoparticles delivered folestatin mRNA to mice with ovarian cancer. endogenously produced follistatin, neutralized active in A, prevented malignant ascites, delayed progression, preserved muscle mass, and synergized with cisplatin to extend survival. So again, when these mice that had cancer specifically ovarian cancer were treated with folistatin, it actually improved their health markers.

11:57 So again, this was mRNA delivery and it was a bioactive product is endogenous folestatin protein. Again, a little bit different than the injection of folostatin but mechanistically it seems like it's doing positive things. And again that was the 2022 study in mice. Pretty interesting there. This one's actually pretty interesting and it's kind of funny because again, a very, very popular peptide, but no one is really talking about what it is doing in terms of cancer. So let's look, 2014 study from Lauren Pickert, who was the original Discover of GHK connectivity map analysis looked at GHk and it reversed 70% of 54 overexpressed

12:38 genes in metastatic colon cancer signature and activated six of 12 human capsase genes. So basically it's working on gene expression to help improve cancer outcomes. Another 2021 study looked at GHK and it showed that modulated cancer-relevant gene expression in MCF7 breast and PC3 prostate cancer cell line. So again, not a human study, but very interesting nonetheless, that it led to that outcome in cancer, cell lines studies.

13:09 Again, I think GH K would be absolutely one of the more positive ones, Not that is going to treat cancer but in terms of creating an environment in the body that's favorable to health and not favorable cancer. Kispeptin, this is pretty interesting. The interesting thing, there's a ton of studies on KISPeptin. So KIsPepton-1 expression in metastatic human melanoma cells injected into nude mice, suppressed metastesis by 50 to 95% in an expression-dependent manner, tumor formation and injection site was not blocked, and the distance spread was.

13:39 Now, what I think is interesting about kisspeptin when we look at it is that I, think because of it's basically being similar to testosterone therapy, not the same, but similar, the hormone cascade that is created as a result of improving hormone levels in the body, specifically reproductive hormone, levels is actually positive, Not negative for cancer. Again, that will be a whole different conversation that i could look and cancer myths, but today we're going to stick to peptides. But I think it's interesting because kiss-peptin would be like a diet version of testosterone therapy.

14:13 Not going get you where you need to be, better than nothing. This was interesting, a 2017 study, KISS Peptin 10 activated EIF2AK2 in metastatic cell lines in nude mice, it inhibited LOVO xenografts tumor growth and reduced lung metasysys. And then deleting that specific line abolished the effect. So we do see that it reduced long metasisys in the mice that were injected with KIS PEPTIN. KPV, very interesting with KPB.

14:44 I'm a huge fan of KP, I think it's one of the most underrated peptides out there. It's the best anti-inflammatory that we have, at least right now. 2016 study looked at mice given basically colitis assisted colon cancer. received KPV in their drinking water and KPB significantly decreased tumor size, number, and total burden. The effect required PEPT-1 knockout mice showed no benefit, confirming PepT1 mediated uptake and the mechanism was via NF-kappa-B suppression,

15:16 breaking the chronic inflammation to cancer chain. And so again, cancer can be different to different people, but a lot of times it's going to stem from inflammation. What I love about KPV, it is such a potent anti-inflammatory and works so well, really for the gut, a ton of other areas. In this case, KPB just in the drinking water of the mice significantly decreased the tumor size number and total burden. And, so, again I think when we look at peptides, why is no one talking about this? Everyone is saying they're causing cancer. Here's direct evidence that KPD, one of best anti inflammatory peptide that we have, was obviously taking mice that had colon cancer and reducing the tumor

15:54 size number and total burden on them. So again, very powerful there. And again one of the favorite peptides that I have, I'd put it in my top five every day. LL37, this is pretty interesting because a lot of people will say, I've heard sporadically people say doesn't Ll37 cause cancer? I think what people were referring to is that Lll37 is a natural by-product inside the body that responds to when something's wrong. And so it would kind of be like looking at a crash on the side of the road and saying that the fire trucks that are there to help that crash cause the crash.

16:25 The firetrucks are their to repair the damage and try to clean everything up. And so when we look at these, we have to look some of these things in the body is actually there to like help repair the damage rather than being causal. And in my opinion, that's the case of what's going on with LO37. Obviously we don't have a ton of human data to confirm that. But just because something is present in a body as a response to the inflammation doesn't mean it's causing the information. It is the actually the bodies mechanism that is trying to fight off whatever it is. Let's look at LL37. So a 2012 study looked at an induced capsaicin-independent apoptosis in colon cancer cells, and Ll37 deficient mice developed significantly more colon tumors.

17:06 And so in this case, when they were deficiente of Lll37, they developed more tumors, meaning that LLL37 was actually working to suppress the tumors Also a 2013 study, there was an FK16 fragment induced both capsase-independent apoptosis and pro-death autophagy via p53 modulation in colon cancer cells. So again, evidence there to show that it was working to kill cancer. Melanotan-2, this is actually another one that is kind of interesting because melanothan 2 is thought of like, oh, if you take too much of it,

17:37 that could cause skin cancer. Again, we don't know. However, there was a study done in 2019 with topical application of melantan2 in mice with B16F10 melanoma. And the Milan 10-2 actually shrink tumors to 50% of control size over 10 days. It induced apoptosis, reduced Ki-67 proliferation and microvessel density. And also blocked the migration, invasion and colony formation of the tumors. So again, we don't have a lot of this data around Melanotan-1, which is actually FDA approved, and there's lots of human data.

18:10 We do know that Melantan 1, at least in the human, data is not increasing the incidence of cancer risk. I think Melatant 2, obviously less studied and people don t know as much about it. And so that is a fear. Oh, am I going to get skin cancer from this? Well, there was a study that topical application shrank tumors in mice that already had melanomas when they applied it to it, so very interesting there. Again, What does that mean for humans? We don't really know, but that's data suggests that would not be causing cancer. And in fact, it's reducing the tumor size over even a 10 day period.

18:43 Motzi, very interesting. We haven't studied motzi specifically for cancer, But I think when we look at the metabolic nature of cancer anything that we talk about today in terms of enhancing the metabolism is going to be really good to create an environment in the body that is not favorable to cancer So what's interesting is when we look at patient samples, so MOTC was reduced, MotC levels which are endogenous to the human body were reduced in ovarian cancer patient tumors and serum. So lower levels predicted worse survival, which is interesting. Again, does that mean that MotsC is going to be the reason that someone gets cancer if they're deficient?

19:17 No, but we do know that that is correlative. Also in vitro, exogenous mozzi block the proliferation, migration, and invasion of cancer cells that also induce cell cycle arrest and apoptosis of cancers cells. And then in mice, there was a marked anti-tumor effect in mouse xenografts without systemic toxicity. This was thought to be through the LARS1 ubiquination via USP7 competition. So again, when we look at mozi, something that again is a direct anti cancer agent, We don't know, but it does seem to be creating a metabolic environment

19:51 in the body that is favorable to health and not to cancer, which is pretty interesting. Reddit True Tide. I love Reddit true tide. Who doesn't love reddit true tied, right? So this is interesting, I think when we look at the GLPs and you can't really make this argument, although I there was something with semaglutide, But Reddit, true Tied in terms of pancreatic and lung cancer. This was a, 2025 study. So an obese mice with pancreatic and lung cancer reticulatide produce a 14-fold reduction in pancreatic tumor volume versus fourfold for semaglutide and

20:24 a 17- fold reduction and long tumor, volume with 50% less engraftment. The anti-tumor benefits persisted after the weight regain in mice and the mechanism we believe is through immune reprogramming. Elevated interleukin-6, more antigen presenting cells fewer immunosuppressive myeloid cells. So again, the tumor reduction was massive with reticulotide and it was even that much more than semaglutide. Again, this will probably be one of the things like 10 to 15 years from now, we're going to have a lot of human data around this to validate the fact that

20:58 it's reducing cancer risk. But I think there's just going be more and more data showing that the GLPs are actually reducing incidents of cancer and cancer risk. So again, we love to say in the social media world, peptides cause cancer. Look at what Retatrutide is doing mechanistically to reverse tumor size. Here's where we do have more data. So we have semaglutide. We know from semoglutar users, and it's just because we a larger data set from semi-glutar than even trisapatite or retitrutide,

21:28 65% reduction in the incidence of gallbladder cancer versus insulin users. And that was across 1.65 million patients. Reduction by 59% of pancreatic cancer for semaglutide users. Redduction of 53% for hepatocellular carcinoma or liver cancer. reduction of colorectal cancer by 46%. GLP-1s associated with a lower risk of 10 of 13 obesity-related cancers over insulin. A 2025 study confirmed reduced colorectal, liver, and pancreatic cancer rates versus DPP4.

22:04 And then another study in 2024 with 145,000 patients found no increased thyroid cancer risk of that. So when we look at semaglutide, again, I think these will even continue to get larger and bigger. We just have more of a data set around that now showing how powerful it is at being anti-cancer. Again, very good there. SS31, another good one. Again, this is not really, you're not going to see a lot of data around this because it's not studied that much, but I did find one study in 2021. In C26 tumor-bearing mice receiving chemotherapy, SS 31 prevented mitochondrial dysfunction, restored ATP, and reduced glycolytic muscle fiber loss.

22:41 It also did not interfere with chemo's anti-tumor effect. So this is chemo protection, not tumor killing. So again, no direct evidence. Although I do think metabolically SS31 is going to enhance the environment that would not be favorable to cancer. But what is interesting is that it basically offset all those negative side effects of chemot and allow the chema to work. And so take for that what you will, but depending on whether someone's struggling with cancer, I know if I was in that situation and I had to go through chemo, would be doing a lot of SS-31.

23:11 I will say that. Take for what that you, will I'm not recommending it, But very interesting there that it did not interfere with the effect, it prevented a of the side effects that came from it. Thymolyne, pretty interesting. I love thymolyn. It's very not talked about that much, but chronic thymus factor in disease mice decreased spontaneous tumor incidence and prolonged lifespan. So in rats with transplanted sarcoma 45, thymylin arrested or regressed tumors in over 50% of the animals.

23:41 Others showed around a 78% growth suppression. So 2003, Caventin report of humans also reduced all-cause mortality was not cancer specific and it did not cite cancer evidence, but there was longer lifespan for people using thymalin. And so very interesting there that we see this. Again, it makes sense if you're enhancing the immune system that that would happen. So I don't think this is again, anti-cancer directly, But if your enhancing immune systems, immune is going to function better and we're going be less likely to get cancer. Thymalin, pretty popular. Thymosinophil-1, this is probably where we have the strongest human clinical evidence, because it's actually studied alongside of cancer,

24:16 which is interesting. So let's just look at this. This goes back to 1995. There was a study with 56 patients. The median survival improved by 12.6 months, and they had improved natural killer cell activity. 2009 study, there was, again, thymosinphil 1 were studied alongside of cancer treatment and the outcomes improved. 2010 study diamonds alpha 1 added to chemo improved tumor response and overall survival in 488 stage 4 melanoma cancer patients.

24:53 2016 study 146 diamonds and alpha one treated versus 412 controls post hepatotectomy improved recurrence free and over all survival of people with hepatocellular carcinoma. And then another 2018 study with melanoma treatment or melanomas patients, thymosanophil-1 pre-treatment followed by checkpoint inhibitor showed extended median overall survival and possible immune preconditioning. So again, in a lot of cases, Thymusanphil 1 is being used as an adjunct to cancer therapy, such as chemo or other things.

25:24 And it is in every instance enhancing their survival rates and the reoccurrence rates for those people. Is it going to be the only thing you need to treat cancer? I would say probably no, but very interesting that it's doing a lot of these things and no one really talks about it and this is not FDA approved, even though it was approved in 35 other countries at the time to my knowledge. Truzapetide, I know, you know we kind of talked about semen glutide and red truotide. 2024 study in obese mice with triple negative breast cancer, truzapitide suppressed mammary tumor growth and mitigated obesity driven hormonal changes.

25:57 In the colon cancer model, it restored anti-tumor immunity and a 2025 cohort also showed reduced obesity associated cancers with trzapatide so again, i don't need to go into that. We obviously know the GLPs are enhancing the metabolic environment which is an improving cancer outcomes, but again, data there for trans-apetite as well. I thought this was pretty cool, VIP. So VIP, vasoactive intestinal peptide, one of my favorite peptides, especially for people that have autoimmune disease or their nervous system is fried, it kind of helps relax you. But they looked at VIP in hepatocellular carcinoma, And basically what it did is that the carcinoma was reversed by the VIP.

26:37 So it increased capsase 3, decreased BCLXL, and induced apoptosis of cancer cells. Pretty interesting there. Again, very little data around that one, but I think that would be another one that I would put on the list. And then just to kind of sum up, Obviously, these are not FDA approved cancer therapy. So I'm not telling you to do these. Obviously these were things that have not been replicated to scale whatsoever. And again, just because it's preclinical does not mean that it is recommendation. But I want you understand that for every time you hear someone say this, there's as much data that we can look at here today to show us that is not not

27:14 favorable to cancer, but not only is it not favored cancer in a lot of cases, it's reversing cancer. So that is for the slides. And that my list of peptides that have direct anti-cancer evidence. What I'm not telling you in this video is that peptide heal cancer that's absolutely not what I am saying. You have to talk with your doctor, you have figure out what that if that something in your life. However, what is interesting is we have a data to support the fact that there is favorable evidence against cancer from some of these peptides. So the next time someone tells you, hey, these are peptide, they are dangerous.

27:47 They may be causing cancer. Say, Hey, well, what about this video where there's over, you know, 20 to 30 studies where we show that they're doing things. And so I think obviously context is very important. What peptid are we talking about? You probably noticed that I didn't have a lot of the growth hormone peptids. One, because there is not a data around them and cancer, But also too, you know, we just don't know at this point. So would I say that injecting a growth hormone peptide for someone that is riddled with cancer is the best idea? Probably not. That might not be the thing. But if you're pretty healthy, if your doing all the right things, your eating right, training right living right doing, all those things.

28:19 Could a Growth Hormone Peptide just magically cause you to create cancer? I don' think so. Again, that's just my opinion. And so take this for what you will. It's Just data. Look at the data, You have to be informed consumer of what your'e doing. But I think for the people, I know that there are a lot of people out there that are scared to take peptides because of the big C word. And I would say you have to do what works best for you. But as much data as you can hear from someone that's a lotta times just making stuff up based on theory and mechanisms of theory, and this doing this, there's as evidence in the other direction.

28:51 So hopefully, if anything, this will just be a good evidence counter for you to really sit and think on if this is something you're worried about or if you hear this out there and it's something that you are concerned about. So again, go forward and do with this what you will. But in closing, thank you guys so much. I am so blessed and honored. The fact that I get to make presentations like this and people watch them and its even remotely interesting to them is a dream come true for me because I could geek out on this stuff all day. whatever shape form or fashion this you support me whether it's liking, commenting, subscribing, sharing this with your friends and family.

29:23 Hopefully this is a good shareable video. Being on the email list using my code at places and even to all the people that are my private group thank you guys so much. It means the world to me to be able to get to do these things, dream come true and I just always want you to know that through supporting me, to bring these messages to you, you are appreciated and you're loved. So Thank you guys. I would love to hear your feedback on this one. If this was helpful to you, I'll make sure to post those links down in the description and I will look forward to seeing you in next one, peace.