Boost Your Immunity Defy Aging with Thymalin

0:10 Hey everybody, this is Dr. Williams. I hope you're doing amazing wherever you are out in the world. Today's video is going to be all about the injectable bioregulator thymulin. So I'm going talk about this a little bit towards the end, but thymylin is spelled T-H-Y-M-A-L-I-N and there's another peptide called thimulin, T H Y M U L I N. And it'll distinguish the difference between those at the N, But if you aren't looking to boost your immune system, you definitely want to try thysmulin with an A and that's what I might be talking about. for the majority of this video.

0:41 Thymelin is actually the peptide bioregulator that works specifically on thymic tissue or the thimus gland itself. And it's pretty cool. I've actually been playing around a lot with it myself recently, and I definitely noticed an improvement in my immune system and improvement and my gut health. Things were fine to begin with, but I'd been traveling a little bit lately and noticed my system seems to be really resilient. Overall, I just seem to feel very uninflamed, if that makes sense, given the barrage of traveling and different sort of stress,

1:11 whether it be environmental stress work stress and other things that I've been up against lately, which we all deal with in life. And I am not immune to that as I'm sure you go through on your, in your daily life as well. So I really like this peptide and what's cool about thymalin In regards to the thymus is after the age of 30 our thimus gland begins shrinking dramatically year over year. And that's why as we age, our immune system tends to go down. Now metformin and growth hormone and a host of other things that we can do over time really help it. But I think for people that are aging and just want to maintain a really strong immune and stay young, Thymalan's great,

1:44 but also too, if you sort of suffer from any sort autoimmune disease or chronic fatigue or anything like that, that would be lumped into the auto immune disease category, it's really cool. So that's what we're going to dive into today. Before I share my screen, don't forget to check out the peptide cheat sheet. I've got the dosing for thymalin on the new peptides sheet sheet, If you want to download it, obviously if your on my email list, the link to that is always in the description. But today's going to be really cool. I'm going walk through thymalin, what it is, why it matters, how to use it, and then ultimately what we can stand to benefit from using. So let me show my screen and let's jump into it.

2:17 All right, I am Hunter Williams and todays video is all about thimalin. And the question is is this the best immune system peptide yet? I think it's up there alongside thiamin-synophil-1. Let's get into. It can also be sometimes called Timelin or Timelin, but Thymelin is an injectable thymic peptide, bi-regular originally developed along with almost all these bi regulators in the Soviet Union as an immunomodulatory drug. So basically it is a complex of peptides derived from the thimus gland, typically from young bovine thimas designed to normalize or support immune function.

2:48 Thymalin has been used to restore immune competence in cases of immunosuppression to enhance resistance to infections and even as part of anti-aging protocols. Specifically in this video, I'm going to be talking about injectable thymaline. I do believe you can probably find oral thimalin capsules out there somewhere. And there is an oral Thimus bioregulator that you could use. It's called Vladonix that we sell at Bio and Longevity Labs. So if you want the oral version, check out those. on those in the future. But today I'm going to be talking about thymalin because in my opinion, even though oral bioregulators are great, I think injection always has the highest

3:20 efficacy and highest response that I've noticed just in using them on myself. So let's look at the history of it. In the 70s, Professor Vladimir Kevenson, rest in peace, and colleagues in St. Petersburg were among the pioneers investigating these peptide bioregulators, which are small peptides from organs that could regulate bodily functions. So they isolated peptids from the thymus and the pineal gland, among others under the hypothesis that age-related decline of these organs could be mitigated by supplying the missing peptines that we lose as we age. So extensive animal studies were conducted from the seventies to the nineties to characterize these compounds and effort was part of a broader Soviet interest

3:57 in gerontology and space medicine, maintaining astronauts and common hots health where such regenerative therapies were highly valued. So did get something good out of the cold war. It was originally developed as purified thymus extract from calves or baby cows. In 1974, initial clinical tests suggested it could boost immune responses in animals. So from there, the manufacturing process was refined to ensure safety, notably an acid extraction and ultrafiltration method was used to eliminate large

4:28 proteins and potential pathogens, yielding only small peptides under 10 kilodaltons in the final product. So this is also how most of these peptide bioregulars are formulated. So just replace thymalin with whatever other tissue from the animals that was done. This is what they were doing in this case, and this was what we're doing back in the seventies. But it showed promise in restoring immune function in irradiated animals, that were exposed to radiation poisoning and those with experimental immune disorders. The first clinical uses of thylalanine in humans came in late seventie, where it was given to patients with immunodeficiencies and cancer,

4:58 showing positive immunological effects and helping with their recovery. In 1982, after a series of clinical trials, it was officially approved by the Soviet Ministry of Health as an immunomodulatory drug and it determined safe and effective as a peptide immunocorrector. So it made it part of standard medical practice in the soviet union for treating immune dysfunction and was produced by pharmaceutical companies such as Samson Med, which is a Russian company and made available in hospitals there.

5:30 And then it was continued to use or was used in the 80s in immunology clinics, including applications in post Chernobyl radiation exposure. This is why I wanted to include some history because I am fascinated by this stuff. But it is used and people that were exposed to radiation at Chernobil. And then after the Soviet Union fell, thymelin continued to be produced and used in Russia under some post-Soviet states and it is featured on the Russian list of essential medicines as an immunomodulator. And over the years, millions of doses of thylalin have been administered, establishing a track record of safety and moderate cost.

6:01 It is fairly cheap and has fairly powerful benefits and up until recently has not been accessible in the Western world. Then we move into the 90s, Kevin's team treated elderly volunteers with yearly thiamine courses and observed increases in their longevity parameters. So the results were presented later in journals in the early 2000s which garnered interest worldwide in anti-aging properties of thymus peptides. Now, during this time, analogs and subsets, subset peptides from Thymogen were developed. We have one called ThymaGen, which you've probably heard of.

6:31 It's an oral capsule that you can buy on the internet. That was isolated in the 80s, and later produced as a drug. Still used today. And it's also used as nasal spray. Then other peptide, like Velon and Crystogen, were studied for gene regulation effects, eventually marked as supplements. in some countries and thymalin itself became one of the flagship products of The St. Petersburg Institute of Bioregulation and Gerontology, which has continued research into peptide therapeutics. So this is definitely one the hallmarks of this. And then we just look at that on a broader world perspective. This is interesting to note that I think Western medicine is years behind some of other parts of world and I medicine as a whole is probably,

7:07 I've heard 70 to 100 years, behind the literature of what's out there that we have access to, that implement in practice today. So Western scientists were more focused on single thymus hormones like thiaminsins and thiemulin rather than complex extracts. However, similar products do exist. For example, thimomodulim, which is a thamus extract pill developed in Italy, and thymostimulin, a thymic peptide injection used in certain European countries are conceptually akin to thimalim. And so just kind of goes to show that this is something that does have efficacy.

7:37 But in recent years, Thymalan has gained international attention through biohacking circles. Thank goodness. And regenerative medicine is available through peptide supply companies globally, often advertised as a research chemical. What's funny is it's considered a resource chemical in the Western world. But in Eastern world or at least in the former Soviet Union or Russia, it has been used clinically and approved for what now almost 50 years at this point. So the success of thymus rejuvenation studies like the 2019 TRIM trial in U.S.

8:10 which used a growth hormone go figure, DHEA and metformin to actually regrow thymus tissue, another point in the column for a win of growth hormone, has indirectly boosted interest in thimus peptides like thiamin. So while thamalin is not an FDA approved drug in United States or the EU, some practitioners legally imported or compound similar thamus extracts for patients. As of today, Russia remains the main country where thamylin is part of conventional medicine. But knowledge of it is spreading and hopefully in the United States, it becomes part of conventional medicine, especially with all the chronic illness

8:41 we have out there today. So let's look at the composition of that. Thymalin is not a single peptide, but it's actually a polypeptide complex derived from the thymus gland. It was originally obtained by extracting the thymos tissue from cows under conditions that isolate small peptides while eliminating larger proteins and potential pathogens. The manufacturing process yields a purified mixture of low-molecular-weight peptides, which are generally short chains of amino acids, and in fact, peptide with a molecular weight up to about 10 kilodaltons are preserved in the thymaline extract, whereas large thamic proteins are removed

9:13 during production. So the enrichment of small regulatory peptids is thought to capture the Thymus gland essential immunoregulatory factors in a form suitable for therapeutic use. Which is pretty cool. So I mentioned it was a peptide fragment, so it's actually made up of the following peptides. These three short peptids in particular have been characterized from thymidine's composition. It may sound familiar to you. We have EW dipeptide, which is a two amino acid peptid of glutamic acid and tryptophan, and this is isolated from Thymiden and later synthesized into thimogen,

9:44 what you have probably seen for sale as a supplement in the United States. We also have another one called KE dipeptide, which is also known as Vlon or Vilon. I don't know how you pronounce it, but I've also seen this and had amazing results with this as just kind of an immune slash inflammation suppressing peptide. But it is a component of thymolin. And it has shown bioactivity and modulating cell differentiation and gene expression. It is another active component contributing to the effects we get from thymolin. And lastly, we have chrystogen, which you've also probably heard of.

10:15 To three amino acid peptide of glutamic acid, aspartic acid and proline. It has its own biological activity and is thought to support immune cell development and antioxidant fences. So those are the core active ingredients inside thymine, which is pretty cool. Each 10 milligram or 20 milligram vial, depending on what you buy, contains thimus extract along with an incipient, usually glycine for stability. And because it's derived from natural thamus tissue, it encompasses a broader range of peptides than a single isolated hormone.

10:45 So in practical terms, what does that mean? It means that thymalin's composition allows it to influence multiple targets in the immune system simultaneously, which may explain its broad spectrum of benefits. So that's a little bit of background. Now let's look at some of the documented therapeutic use and applications of thylalin. The first one is going to be immunodeficiency and immune support. It is officially indicated for uses in immunosuppression of any origin. So this could include immune efficiency due to stress, chronic disease, or other medical treatments.

11:15 So for example, thymine has been used to boost immune recovery in patients after radiation or chemotherapy in people with HIV or AIDS, and those for recovering from severe infections. And so by enhancing T cell counts and normalizing immune ratios, it helps immunocompromised patients mount better defenses, And doctors in Russia have administered thiaminoline to patients with secondary immunodeficiencies observing reduced incidence of opportunistic infections and faster restoration of normal immune markers.

11:45 So it definitely has a broad range of compatibility with other treatments as well. It also works in acute or chronic infections. So a well-established use of thymalanin is in the prevention and treatment of infections, so studies have shown that adding thylalanine to standard antimicrobial therapy led to quicker resolution of the infection and fewer complications. In viral illnesses such as recurrent herpes or infections or hepatitis B has been used to stimulate the immune system to better control the virus. often resulting in longer remission periods.

12:16 And then the peptide thymogen, which is derived from violin, is even used as a nasal spray for prophylactus during flu season, indicating the role of thamic peptides in warning off common viral infections by keeping the immune system alert. I actually would use thimelin for that case too. Due to its effect in normalizing immune homeostasis, thimmelin is thought to help the body clear infections more effectively and resist new infections. So it's pretty cool. When we look at all the things we're upping against, and I think especially relative to gut health, whether it's parasites, SIBO, any of those things.

12:46 It's just one component that can really help. it also has been shown as an adjunct in cancer therapy, so it is a history of use as a immunotherapeutic adjuvant in oncology. In the 80s and 90s, oncologists in the USSR incorporated thymalin in treatment regimens of patients with solid tumors. And so the reason behind this was strengthening the patient's immune system was thought to help fight the cancer and reduce immunosuppressive effects of chemotherapy and radiation. And ultimately clinical reports indicated that Thymalan's administration in cancer patients improved immunological indices like increasing lymphocyte counts

13:19 and function and help reduce side effects such as severe leukopenia, infections, and poor wound healing. Some studies even noted longer disease-free survival in cancer patients who received thymic peptides, though these observations were not always from randomized trials. And today, while thiamine is not a mainstream cancer drug, it's still of interest in integrative oncology. So again, I don't get into much into talking about C-word type things, but just know that thieminein is out there. If we're going to do everything to help with our immune system, Thymalan would be one of the first things that I would go to.

13:53 Now let's look at tissue regeneration and recovery. So because thymalin promotes cell differentiation and reduces apoptosis has been used to aid tissue repair and regeneration. Doctors have actually employed thylalan in patients after major surgeries or injuries to accelerate healing. Not only are we seeing it from the immune system side of things, but If we have any sort of surgery or major traumatic event that we're recovering from, it can speed that up as well. So it appears to improve wound healing, likely by supporting the immune cells like macrophages and lymphocytes that coordinate repair and by increasing

14:24 circulation to damage tissues via its influence on cytokines and blood flow regulation. One study even found that surgical patients given thymalin had fewer post-operative complications and their incisions healed faster with less infection compared to controls. So definitely if you are undergoing surgery, unfortunately, if that's the case for you, I would absolutely recommend thylalin as an adjunct to help with the immune system's recovery pre and post operation. It's also been examined in some chronic conditions such as non-healing ulcers or after heart attacks with the idea that bolstering the immune system and stem cell mobilization could improve outcomes.

14:55 And while not a primary indication, these regenerative uses align with a pro-recovery effect that users in biohacking are looking for and hope to get. And then we have anti-aging protocols. So obviously all of that stuff is cool, but what if you just want to live long, live strong, be the healthiest virgin yourself? And this is where I think Thymalon is really cool if we just use it a couple of times throughout the year to enhance our immune system and enhance the regrowth of the thymus that is shrinking as we age. So studies have shown that thymaline can improve health span and even extend lifespan in elderly populations, and some visions advocate intermittent thylmaline

15:30 courses in middle-aged or older adults to rejuvenate the immune system. So a common protocol is to take thyrmalin injections once or twice per year, which we'll talk about, often in combination with the peptide epitalon, what you can definitely use alongside of it. to attempt to slow down age-related deterioration of the immune and endocrine systems. And so users usually report fewer infections, improved energy, better skin quality, and better hair. Biomarkers suggest a younger immune profile, which again makes sense because if we are maintaining a youthful immune system, the body is not going to age and oxidize and get stressed out as bad over time.

16:04 And so, although obviously this is from the research world and it's anecdotal, there is promising clinical data from formal studies and thymalanine has been proposed as part of immuno restoration therapies for the elderly aiming to counteract thiamus involution that comes with age. And so by providing external thymus peptides, one can mimic a more youthful thamic environment, which translates to the rest of our body. So beyond longevity, there's also interest in thiamin to be seen as a tool to combat aging over time.

16:35 We also have autoimmunity and neurodegeneration, which are obviously two things that are big in the line of, I would say, chronic issues that people experience in world today outside of obesity. It seems like autoimmune disease is the next chronic issue that a lot of people struggle with. And then obviously neuro degeneration is on the forefront of taking off in terms of the amount of people that are experiencing. So thiamine, due to its broad balancing effect, might help normalize immune responses in conditions like autoimmune thyroiditis or rheumatoid arthritis,

17:06 though direct evidence is still just kind of in the beginning. Thymulin, which is the one with a U, has shown interactions with the nervous system, providing anti-inflammatory effects in the brain. And while thymuline hasn't been directly studied for neurodegenerative diseases, there is speculation that improving systemic immunity and reducing chronic inflammation could be beneficial for brain aging as well. And some biohackers are experimenting with thymalin to see if it improves cognitive clarity or recovery from brain fog. And I will say just personally, as a quick anecdote aside, after running courses of thylalin, I definitely noticed a pickup in cognitive function that

17:39 is not stimulatory in any way, but definitely helps me focus. I just feel more mentally alert over time. Now I get it, i'm doing a lot. A lot of peptides and different things, But I noticed within a few days of taking thyrmalin that seemed to have a pick up effect. Another emerging application is endocrine rejuvenation. So since thymus extracts can influence hormone levels indirectly, there is interest in using thiamine to support endocrine glands, like improving adrenal or thyroid function. I definitely do think, even though I would say it's not going to replace something like desiccated thyroid, that it is a very healthy adjuvant to add in

18:18 to desiccated thyroid or if you're not going to do that to use alongside to help with your thyroid and adrenals. So I definitely notice when I've used thymalin that fat loss seems a little bit easier in the context of the use there, which makes sense. Let's look at some clinical research and evidence on thymalin. So multiple studies report that its therapy has helped restore impaired immunity.

18:49 So trials in patients with chronic lung infections and pneumonia showed that adding thymalin reduced systemic inflammation and helped normalize blood coagulation and fibrinolysis parameters indicating an overall dampening of excessive inflammatory responses. In immunodeficient states such as individuals who had their thimus removed, thamalin injections led to market improvement in immune health and reduction of injection or infection frequency, excuse me, Freudian slip and such immune benefits make thymelan of interest for conditions ranging from recurrent

19:19 respiratory infections, severe viral diseases and also Thymelin as an adjuvant therapy in COVID-19 to potentially help elderly patients by reducing cytokine imbalances in coagulopathy, though we don't have formal trials on that. But I would imagine if you experienced COVID or experienced long COVID, or anything of that nature, hey, that may be something you want to look into. Wink, wink. Let's look at some research along the lines of longevity and aging. So a large clinical trial in 266 elderly individuals over 60, over 68 years found the periodic course of the thymine produced significant improvements

19:55 in multiple systems and reduction in mortality. Specifically, thiamine treated subjects showed improved indicators of immune, endocrine, cardiovascular, and nervous system function. fewer acute respiratory infections and lower incidence of age-related diseases such as ischemic heart attack or ischaemic disease, hypertension, osteoarthritis, and osteoporosis compared to controls. And more importantly, the 68-year survival data showed a 2 to 2.1-fold lower mortality rate in the thymalin-treated group versus untreated controls Next,

20:26 when we combined it with a pineal peptide like epithelium or epitalon, one regimen of annual epithelium, or excuse me, thymalan plus epithylamine courses for six years led to a 4.1 fold reduction in mortality compared to controls. And also too, this is again one regiment, which is going to be like 20 to 30 days. So pretty cool. This suggests thiamine has a geroprotective effect in humans, potentially by rejuvenating immune functions and restoring homeostasis in older age. and also animal research aligns with some of this. So here's a few other studies that I was able to find through searching.

21:00 Studies in patients with advanced cancers, e.g. cervical and endometrial cancer reported that thymalin improved immune parameters and reduced treatment complications such as leukopenia, which is low white blood cells. Some trials noted post-operative recovery and wound healing when thylalin was given around the time of surgery. In patients would TB, tuberculosis, and chronic infections, thamalin added to standard therapy accelerated recovery and immune normalization. There's also animal studies indicated that thymalin might have anti-tumor and cardioprotective effects. For instance, long-term thamalin administration in rodents was associated with a lower spontaneous tumor incidence and protection against experimentally

21:38 induced atherosclerosis, which is pretty cool. And although many of these were conducted in Russia and some are not known in Western literature, they provide evidence that it can enhance immune surveillance, reduce inflammation and improve resilience against a broad range of stressors. So here's everybody's favorite part, the dosage, right? Now you're probably skipping ahead of this. if you clicked on the timestamps. So good on you for skipping to head to the most important part. But let's look at some of the dosage.

22:08 For standard immune restoration, which is going to be moderate immunodeficiency slash recovery from biobacterial infection, typical adult dose is gonna be 10 milligrams, IM or sub-Q. I recommend sub Q. And we're going to do that for five to 10 days. And so over the total course, we are going get about 50 to 100 milligrams in. So what that means, if you are gonna do a hundred milligrams total, you would buy five 20 milligram bottles and then repeat after a great, after three months if needed. This is the most common one used in Russian protocols. For people with severe immunosuppression or acute critical illness like post chemotherapy or sepsis, We're gonna to 15 to 20 milligrams once daily IM or

22:45 sub Q for seven to ten days in a row. That's going put us in around 105 to 200 milligrams total. And then this is going to be a higher end of the published range. So just kind of moniker under medical supervision what you're doing. Now for post-operative wound healing support, if we have a surgery, five to 10 milligrams is all you really need. I am or sub-q once daily. We're going do that for three to five days and see how it goes. Then that's going require 15 to 15 milligrams, total, and then we're not going need that much again if it's just after surgery and it is just going help

23:16 speed up that immune repair. Now if we're going to do like an immune tune-up like I like to for flu season travel or high stress periods, five milligrams once daily for three to five days in a row. It's going put us in the total range of 15 to 25 milligrams used and we can do that two times per year. So this is kind of more the biohacking dose. That's probably what you're looking for if you are just looking to add in that extra thing. So in this case, you could really just get a 20 milligram bottle, use five milligrams a day for three to five days. I would even say you can do 10 milligrams today just for 10 days in a row.

23:47 And again, this is if you're perfectly healthy and just wanting a little tune up on your immune system. Then for the longevity slash anti-aging cycle, and this would usually be for people that are over 50, again you combine it with epitalon. or even pineal on two, you would do 10 milligrams, IMR sub Q once daily for 10 days in a row. That puts you at right at a hundred milligrams. And then you do this every six to 12 months. You can do it once or twice a year. This is the Caventin elderly mortality reduction, which was often paired with epitalon. We also can use it in children as well. And the recommendation there that I was able to find from the Soviet protocol is one milligram per kilogram of body weight with a max of 10 milligrams.

24:23 Then we're going to do that IM or sub-q once daily for three to five days. So that puts us at three or 50 milligrams depending on the weight of the child. Obviously for a very small child, you would not want to use that much and it's recommended to that under specialist care. That's kind of the dosing. And again, I think when we look at the bioregulator dosage, it's really more about that cumulative dose. So you could do two milligrams a day, you can do five milligrams per day. But through those cycles, we never really want to exceed 100 to 200 milligrams, one to two times per year. I thought it could be a good, again bi-regulators, very safe.

24:54 To my knowledge, there's not anything that you're really going to have to worry about from overdosing per se, but I personally really wouldn't exceed a hundred to 20 milligrams unless it was something super severe. that you were working with. But that's really easy to do. And I think even at those doses, you're going to notice it. I noticed doing just five milligrams a day profoundly just in terms of what it did for my gut health, my mental energy, and overall just keeping me well while I was traveling. Now, I did say that I wasn't going talk about thymalin versus thimulin. So their names are similar, but they are different.

25:26 The key difference is, one, the composition. Thymolin is a single defined peptide, while thimalin with an A is peptidine mixture. So, thymulin requires zinc to function, thymalin does not. Thymulin targets T cell function. Thymaline supports overall immune health. Theymalin is an approved drug and thymulin is mostly a research chemical molecule, although they're both considered research molecules in the United States. And then thymalin can be purchased in a lot of countries and thimulin is not commercially sold unless it's a research chemical.

25:56 So the difference is, again, thamalin is more of a broad-spectrum immune support, whereas thymyelin is much more targeted to work on T-cell function in the body, which is bad, but just depends on what you're looking for. So just to sum up, thymolin is a peptide bioregulator that can help restore immune balance by supporting the thiamine gland. It has shown benefits in improving immunity, reducing infections, and potentially slowing aspects of aging. And its mechanism is called direct T-cell stimulation and cellular protection. So I think at the end of the day, it is in a very intriguing anti-aging natural therapy with a strong safety profile that I thinks is going to be huge

26:33 going forward in the future, whether it's autoimmune disease, neurodegeneration, any sort of infections or just chronic inflammation over time, thymalin does really good to help stem the tide of all those. So that is it for the slides. And that's my comprehensive overview of thimalin with an A. Hopefully it was helpful to you guys. This is one that I'm very bullish on, having used myself just to see its improvements it's made in my own life. It's worked really well. I do notice, I didn't mention this in the slide part, but I have had much improved sleep since I've been using thamalin.

27:06 Again, Even though I don't like having wearable devices, I've been using an aura ring and I have definitely noticed improved sleep scores, usually in the upper eighties since I'd been Thymalan. Now I do use growth hormone. I use other things to help support that sleep score, but I did notice that when I used Thylalan, it absolutely seems to helps with sleep and improving sleep. So if that's something you're struggling with, It's not the first line of defense that I would use for sleep, But it definitely helps for that. But I am really impressed with Thyrmalan again. It is very simple to use. Just kind of add it in. for people to use and it's something I would absolutely recommend at least one to two times per year.

27:40 People go through a total course of somewhere in the neighborhood of 50 to 100 milligrams of timeline, depending on the use cases I talked about in this video. So that is it for this one. I appreciate you guys. Thank you so much for the opportunity to get to do what I do from the bottom of my heart. or even buying the products from BioLongevity Labs and helping us bring more of these products into the world. I greatly appreciate you guys.

28:10 And that's it for this one. Talk to you in the next one, peace.