DSIP Updated: Dosing, Sleep, and Opioid Withdrawal Research

0:09 Hey everybody, Suntra Williams. I hope you're doing amazing wherever you might be in the world. Today's video is going to be all about DCIP. DCIPS stands for Delta Sleep Inducing Peptide. And I made a video probably 18 or 20 months ago about So I figured it's time to do a new one. And actually, since then, there's actually been literature that I have found that kind of gives an updated and informed look into DSIP. Thanks to you guys through submitting questions and suggestions into my question box, which is always in the description of the videos,

0:46 I was turned on to some older literature around DSOP actually being used in opioid withdrawal. So DCIP, most people think, okay, DCEP is the sleep peptide, right? Yes and no. It's actually more of like a circadian rhythm peptides. That's really cool. And by being a circuitian rhythm, peptid, it can absolutely help with sleep. Today, I want to go over just some updated info that I have come across since I last talked about DCP. Also give a little bit of an update to the dosing because I've played around a lot with the docing.

1:17 with it. So I'm going to walk through that today. Again, stock peptide video like I normally do, but I want to give some updates compared to the last DSIP video. Now, before I jump to the slides, as always, just make sure that you're on the email list. The link will be down in the description. You can either sign up for the peptide cheat sheet or just signup for that email. That's the best place to be in case I get censored off of more platforms. the good thing about getting kicked off a view tube is I have my email lists. So when I went to Spotify, I could send out, Hey, go to spotify now. And the people that were on my emails were easily able to find me and keep up with the information.

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2:51 Without further ado, I'm gonna share my screen and today we're gonna talk about DCIP. All right, let's jump into it. Today is gonna be all about DCEP, which stands for Delta Sleep Inducing Peptide. DCEP originally was discovered in the 1970s and it promotes deep restorative sleep and offers potential therapeutic benefits for stress, yes, even pain, and also withdrawal symptoms, Which is why I wanted to make a video because last time I know the video I really just talked about the sleep aspect. To give you a little bit of history, DCIP is a 9-amino acid long-shore peptide chain.

3:24 Swiss researchers actually first isolated it from the blood of rabbits in deep sleep during the 1970s. And the short chain of 9 amino acids was named for its ability to induce delta wave sleep, which is the deep, slow wave stage crucial for restoration that we also desperately need and seek. Desip is present in humans in very small quantities in the brain, plasma, and even breast milk, suggesting it plays a subtle but important role in our own innate physiology. And remarkably, DCIP can cross the blood-brain barrier.

3:56 It may be absorbable via the gut and an unusual property for peptides, but also means that you can take a nasal spray of it. And I actually, even though I'm not a big nasal-spray fan, will attest to the efficacy of DCP as a nail spray. Definitely does work, at least in my experience. How does it work? A multi-system modulator, it does not act like a sedative. When we look at sleep aids, everyone wants to say, hey, give me something that knocks me out and keeps me up.

4:26 And it's not really how it works, although it will help. I don't want you to think it is not going to help with sleep, but I want to put the context around it. Instead it acts as a sophisticated modular of different systems of the body, particularly the neuro-indicant and neurochemical systems that together influence sleep and other functions. DSEP itself is produced in the hypothalamus and found in pituitary gland, which also for people, just as an aside real quick, that have any sort of pitutary dysfunction like myself from the concussions that I've had or whatever you may have pituatory dysfunction from,

4:59 I think a benefit from DCEP, especially if you're struggling with sleep, But it helps regulate hormone release and stress responses in the body. And it also adjusts the balance of neurotransmitters and hormones to encourage a state conducive to deep sleep, which is pretty cool. Let's look at the mechanisms of action when we have stress hormone regulation. DCIP, especially when we're talking about exogenous administration, lowers ACTH and cortisol production, reducing stress and promoting nighttime relaxation. It acts as a stress limiting factor in the body.

5:31 it also stimulates hormones and increases luteinizing hormone and promotes growth hormone release by stimulating growth, hormone releasing hormone while inhibiting somatostatin. So you might not have realized, fun fact, that you get a little bit of an increase in growth hormone release from DCIP. Obviously not as much as you would from ipameralin or testimeral or CJC or growth hormones itself, but it's there nonetheless. Pain modulation, I think when we talk about chronic pain, DCI is something whether or not sleep is an issue that could use for chronic.

6:02 It reduces pain perception through anti oceoceptive effects, potentially interacting with opioid receptors to alleviate discomfort. And then also it works on neural pathways. It interacts with NMDA receptors and influence neurotransmitters like substance P to promote calmer mood states. So when we look at peptides for anxiety, DCIP could actually be something that is helping there. When we look at some of the other effects, it works on circadian regulation. It affects body temperature regulation and normalizes cardiovascular function, including blood pressure and heart contractility.

6:37 it also works in cellular energy. A boost metabolism and mitochondria and acts as an antioxidant by activating the body's own antioxidate enzymes. Again, a little bit of everything here. Little bit mitochondrion, little of growth hormone. You see it's doing more things than just sleep. Obviously, when we look at sleep quality, let's break that apart a little bit. Small clinical studies from the 80s show DCIP can significantly improve sleep parameters. Insomniac patients experience fewer nighttime awakenings, increased time and restorative deep sleep and REM sleep, and quicker sleep onset.

7:12 There's faster sleep onset, natural drowsiness within one to two hours after dosing. I will say you are going to do better if you dose it one or two hour before bed instead of right before a bed. It's just how it goes, I know it'd be nice if we could just take it right after bed, but it does help with that. Helps with deeper sleep stages, it lengthens slow wave and REM sleep. There is no grogginess, at least in my experience when just using DSEP. If you pair it with melatonin, you might get some groggyness, But I've never had any groggingness from waking up the next morning, even with doing higher dosings than typically would.

7:43 is out there in the research world. Let's look at some studies around stress and anxiety reduction. Early studies revealed DCIPs, anxiolytic and stress moderating effects. Healthy volunteers reported better relaxation and stressed tolerance in challenging situations. Researchers also described sharply decreased manifestation of stress in subjects given DCIPS possibly linked to its effects on substance P and cortisol production. Animal studies also showed rats subjected to experimental stress had greater resilience when treated with DCIB.

8:13 This is one thing I love to talk about. conceptually is stress and the resilience to stress. We are all going to face life stresses. Kind of a fact of life. You're going deal with stress at some point or another. If not, more power to you, but I know I've had plenty of stress in my life and what is ironic or is the paradox or paradoxical nature of the stress is that some people handle stress really well and it actually makes them stronger.

8:43 Some people do not handle stress really well and it breaks them and can end up resulting in two very different life paths based on how you handle distress. And when we look at our physiology, we can augment our physiology to improve how we respond to stress. I'll give my own example, how I respond distress pre testosterone versus post testosterone. Stress is still there, I am much better able to handle stresses after optimizing testosterone than I was before.

9:16 The same thing that may have broken me before actually can make me grow and make be a better person because I'm better able to handle it. Not that it's fun all the time, but I better be able handle. And when we look at DSIP, the anti-stress benefit may be both direct from the mechanisms it is working on directly and also as a result of better sleep quality. How many times do you not sleep well the night before and then the next day you're more stressed out, right? I know that's my case in times that I may be stressed is not sleeping well the night before. This is what I was talking about when I mentioned withdrawal treatment.

9:49 There was a study that looked at the application of DSIP in withdrawal. And basically what happened, there was an 1984 European trial, that was approximately 100 inpatients that received DSP intravenously during acute withdrawal, typical symptoms were tremors, anxiety, agitation, and headaches. and they rapidly disappeared or markedly improved, often within a few hours of administering DSIP. Obviously, this is IV administration. But relief occurred without standard sedative withdrawal medications that they would typically use.

10:20 In alcohol withdrawal patients, 97% showed rapid symptom improvement. And opiate withdrawal, 87% marked alleviation of withdrawal symptoms. I had a market alleviation of withdrawal symptoms and 100 plus patients were treated in this trial. And again, that is pretty high success if you ask me when it comes to some of the withdrawal treatment symptoms that we're using sometimes pretty strong chemical drugs to treat that I don't think have nearly the success rate that something like DSIP would.

10:54 There was also a 1984, it's weird these 1984 studies, with DSEP, 1984 being the book, not to rabbit hole the George Orwell book. But 1984 pilot study examined DCEP's analgesic properties in patients with various chronic pain conditions, including migraine headaches, psychosomatic pain attacks, and tinnitus associated pain. I get asked all the time, what is the best peptide for tinnitus? And until I did this video, I actually didn't realize there's actually benefits of DSIP and tennitus.

11:28 Six of seven patients, around 86% experienced significant pain reduction after DSP therapy. Pain levels dropped substantially in cases where pain had been persistent and difficult to manage. Alongside pain reduction, patients associated with depressive symptoms improve substantially, suggesting DSIP modulates overlapping brain circuits for pain and mood regulation. I think that's one of those things for people that experience chronic pain. There's also a psychological impact on that of depression and or anxiety. But also another reason that we can definitely use DSIP.

11:59 Additional therapeutic potential. We have anticonvulsant effects. It reduced epileptic seizures and rodent experiments, hinting at potential epilepsy treatment applications. Neuroprotection. That's obviously something that a lot of people are cognizant of now. with the prevalence of Alzheimer's and dementia. Desip-based preparation improved brain electrical activity and cognitive function in children post chemotherapy and a study. And then also antioxidant properties. It boosted antioxidate enzyme levels and reduced oxidative damage in aging rats, suggesting anti-aging potential.

12:30 Again, I think that's probably, in my opinion, a little bit more indirect when we look at the anti aging potential, it's doing all these things upstream that end up leading to a better process of aging to where we're not so inflamed. We don't have so many of these cascades that are causing damage long term. And again, what's crazy about this, to all the people that will say peptides have no human data, is this was 35, 40 years ago that we were talking about

13:02 having resolution of symptoms with DSUP. So where did it go? I don't know. Maybe pharmaceutical companies didn't think that they could profit off of it. But the point being is that there was definitely human data around this, whereas even some of the more mainstream peptides, we don' have human date around. When we look at a study that was done in 1983, there was a Dr. Schneider Helmert and Dr Schoenenberger. They published an extensive report encompassing five different small studies on DCIPS effects in humans under double-blind conditions.

13:35 One, they found sleep normalization. The insomnia patients achieved complete normalisation of sleep patterns. Measures returned to the rained scene and people without insomnia after just four nights of treatment, which is pretty cool. They also had enhanced daytime function rather than causing hangover effects like some things like melatonin can tend to do. These have treated subjects demonstrated higher alertness and improved cognitive performance the next day compared to placebo. And also we saw improved stress coping. The psychological evaluation showed improvements in stress tolerance and mood and participants handled stressors more calmly and reported better overall well-being.

14:11 When we look at safety profile, again, it's been studied more extensively than a lot of other peptides in humans. It is remarkably well tolerated. No respiratory depression, no organ toxicity, next day hangover, memory impairment, and the most commonly reported side effects have been mild and transient, brief headache, nausea, or slight dizziness after injection. Again, I've never really seen that or really even heard of anyone saying that. There was a 20 or 2001 review described as incredibly safe in animal and human studies. No dose has ever even been seen in lethal and animal experience and Human subjects experienced no major side effects, even at relatively high doses.

14:48 Again, when it comes to peptides, obviously long-term is unknown. There is the immunogenicity risk, meaning the immune system might create antibodies against it. And again, I think when we look at cycling, It's one of those things I use it more on an as needed basis. Now, if there is a chronic issue you're trying to heal, you can absolutely use for eight to 12 weeks at a time. You just might have to up the dose or cycle off to keep getting the benefits that you were getting in the beginning when you didn't use. Now dosage protocols, the research doses, if you're doing IV, it's 25 nanomoles a kilogram per body weight.

15:21 Obviously, that's not going to be you guys. If you are listening to this, you will be doing it sub Q. I like starting around the 100 microgram mark and then going up to around 500 micro grams if needed. So again, the typical starting dose is 100 to 200 micrograms, and then you can increase up to 300 to 500 micro grams if needed. Honestly, I never really felt that much, even though I didn't have sleep issues just when I first started trying DSIP. I was like, i don't know that I noticed anything different. But when i go to five hundred micro-gram I definitely notice it.

15:51 i definitely sleep a lot deeper.I definitely have more REM and deep sleep on my ordering. And so for me, if i was really trying to move the needle, that's where i would go. Again, a lot of people take 125 or 150 micrograms and they don't experience anything and it's like, okay, well, let's up the dose and see. And as we've seen, there is nothing to indicate that we have to worry about any downside to that when we up dose. Again start low, go slow, but you may have go up to the 500 micro gram range. I've even heard people as high, I haven't done this myself, people going up one milligram if you really need it.

16:25 And again, 500 micrograms subcutaneously, usually two to three hours before bed would be a good protocol. Again, people have done this in the morning, so there are people that tend to get wired with this. It's much more rare that you would see that though. I like it one, two hours, before a bed. But if you do it, one to two hour before, bed, it kind of helps ease you into the nighttime to, get started with sleep so that your timing up, you know, whether it's like two or three in or four in the morning, whatever it is that your deep sleep is peaking that you can kind of do that because typically it works a little bit better like that.

16:56 I mean, it's not, if you could only do it before bed, that's fine. But if get it one, two hours before a bed on an empty stomach, That's going to be ideal. It doesn't have to an I've actually seen this in nasal sprays. where there's companies, one being Somachem's that sells a spray called Dream Catcher Spray, I believe is the name of it. And they have DCIP with melatonin and I think with GABA, that one works amazingly well too. As a nasal spray, because again, it's crossing the blood brain barrier, there is good evidence to show anecdotally, and myself and other people I've talked to,

17:28 but it does work well as a nasals spray. So if you're someone that doesn't like to inject, hey, you can try DCIPS nasal and it will work. Obviously, we're going to need more studies, although that probably won't happen with it. When we look at DSIP, unlike traditional sleep aids that sedate or knock you out, DSP seems to work by gently rebalancing the body's own sleep mechanism. That's what I love about this. If you don't struggle with sleep issues, I still think you could benefit from DSEP just from a circadian rhythm standpoint. If you're traveling jet lag, things like that. That's one thing I want to be better about is implementing this in a jetlag protocol myself when I'm traveling to get back to a normal circadian rhythm.

18:05 I think that could help me do it faster. And then also to understanding that this is not going to be ambient. I think I was trying to think of the name of a medication that's so widely prescribed for sleep. There's not gonna be an ambient, it is nudging the body back to the state it's supposed to in. And again, It's gonna have this huge jackhammer effect on sleep to like, wow, It knocked me out. And I know people that are insomniacs, that it doesn't really do anything for them. So they probably are going to have to go to more advanced measures.

18:36 But I think when we look at it, it is a tool in the tool belt. If we're using growth hormone or growth hormonal peptide, if we are doing everything right, It's going help in a realm of sleep, at least from a circadian rhythm standpoint. What we do know is that DSEP promotes natural deep sleep without sedation. It reduces stress and anxiety markers. it shows promise for withdrawal treatment. And what we don't know, we do know a lot.

19:07 We just don' know at large scale what the efficacy would be. And again, I've talked to people that even do higher doses and it doesn't really do anything for them, but it's not a panacea. It's on a cure-all that's going to fix everything. So I think DCIP is a great tool that everyone can benefit from. But particularly if you're dealing with sleep issues, maybe you are going through a stressful event in life, the DCI can come in and really help with that. That is it for the slides. and that is my take on DCiP. I'm a big fan of DCip again. I wouldn't rate this like in the top five, maybe not even the Top 10 of peptides, but it's always one I'm going to keep in my house.

19:41 And fortunately for me, whether this is genetic, because everyone in family sleeps really well, I've just always never had a problem sleeping. Thankfully, hopefully I don't in future. meaning that I'm not someone that has struggled with sleep. Now my wife is a different story. She goes through different cycles where she can sleep really well. And then sometimes she doesn't sleep since we've been in this world. Obviously she sleeps a lot better than she used to when she was younger, but DSIP is major benefit to her. she loves DSP. It does amazing things for her, whether she does it as a nasal spray, Whether she injects it.

20:14 DSip is something that is really beneficial to I'm excited to try this more in the context of travel to help with circadian rhythm alignment. I think for someone that doesn't struggle with sleep, that would probably be like the next use case. Obviously there's the stress and the pain aspect of it as well. And again, it's just really cool. think that DCIP is just a sleep peptide when in a lot of cases it can be used for a whole host of different things that are beyond the scope of sleep. And again, what's cool about it, again endogenous peptides, we're just adding it in where in lot cases, especially if we have impaired pituitary function,

20:49 it could benefit because we might not be producing as much as we naturally would. That's it for this one. As always, in closing, thank you guys so much. My heart goes out to all of you, guys. I have so many gratitude for the audience I always tell people I'm the best audience in the world. And I know if you're listening to my stuff, especially if your binge listening, it may get repetitive or old to hear me say thank to you. But I really mean that. To get to do this is my life's work and my mission and purpose and passion. So whatever form It is that you support me, whether you listen, you like, comment, subscribe, share with friends, use my code of places.

21:27 That goes a long way in helping me bring these messages to you. And hopefully in some way through the universe, the information that I bring to that, I'm able to curate helps make a difference in your life. If you reciprocally do the same for me. I just want you to know you are appreciated and you're loved. Thank you guys.