How Id Recover from Mold Toxicity with Peptides Complete Guide

0:09 Hey everybody, this is Hunter Williams. I hope you're doing amazing wherever you are in the world. Today's video is going to be my peptide stack for mold toxicity. So this probably one of the least talked about most prevalent things out there. And the reason being, meaning mold toxicity, the reasons being meaning that very few people know that the symptoms they're experiencing are actually mold, toxicity. A lot of times it presents is this fatigue and lethargy and really what people end up probably diagnosing themselves with or getting diagnosed from their

0:47 doctors with as autoimmune disease. which makes a lot of sense because that's a lotta what's happening in the body. So I'm not gonna go into a huge diatribe today on mold exposure or how it happens or to diagnose yourself with molded exposure. I think the easiest way to do that is just to go to your average blood testing site. You can go lifeextension.com, you can get private MD labs and look for a mold blood test and you go get your blood work done and it will run all these panels to tell you if you have certain mold, exposure, Now, I'm not an expert on that, so don't quote me on what types of mold exposure there are,

1:23 because I don' really know anything about the types or anything like that. But I do know it's a very, very prevalent problem. I live in North Carolina, in the southeast, and it gets very humid here, mold in them because they get old and they can damp and then heats up and so when you have heat plus moisture plus dampness in a building, especially whether it's a crawl space or an area that's been exposed to water damage or something like that in the house or building.

1:54 You can get mold and a lot of times you might not notice there because you don't look in your crawl space or you Don't work in areas that the mold grows and then that infects you and so you get mould in Your lungs or different parts of the body and that makes you sick. So millions of people probably are Experiencing symptoms of this and don''t really know it. That's all I'll say is if you have symptoms that look like autoimmune disease and you can't figure out what it is get a mold test done. Now, I will say what I don't talk about in this peptide stack is the number one thing that I would do if I had mold exposure is take testosterone because

2:26 that would at least give my immune system a chance to overcome the cascade of side effects that will suppress my hormones that would cause me to be sick. So that'd be the first thing. Again, as with most peptide stacks, a lot of the things can be solved or at least improved by using testosterone, but just wanted to get that out there. Before I jump into everything, don't forget the peptides cheat sheet is down below. Most of these peptids in this, the doses do reflect the Peptide Cheat Sheet. I did change some of them because I think for the context of mold toxicity, these dosages will be a little bit different.

2:57 so I will have a chart at the end of this video where you can screenshot your video because i'll have it on the slide. for the dosages that I recommend for this, but don't get your panties in a wind if the doses in this are different from the ones in the cheat sheet because I am addressing the peptides for today in context of mold toxicity. But that being said, if you want a reference guide for all the peptides I'm going to talk about today, they all are in cheat sheets so you can download that and it will get sent to your email. And then also too, If you wanna join the best private community on the planet, check out Fully Optimized Health. The link will be down in description below. So without further ado, I'll share my screen and today we're gonna learn about the Best Peptides For Mold Toxicity.

3:33 All right, I'm Dr. Williams, and today we are going to look at my recommended peptide stack for mold toxicity. So I already did a little bit of a high level overview, but basically mold, toxicity can come from water damage buildings or mycotoxin exposure, whatever that looks like for you and your part of the world in your life experience. But it can trigger chronic inflammation, immune dysregulation, mitochondrial damage, and even tissue injury. So there have been a lot of peptides that have come to the forefront in years that not necessarily are designed for mold toxicity,

4:03 but they do address a lots of the symptomology and the root cause of what is going on with the mold toxicities. I think we can use those. These are ones that I have used a lof of cases for autoimmune disease. It's going to look very similar to an auto immune disease stack. But we're going to talk about it in the context mode. So let's look at LL37 first, obviously an antimicrobial peptide, antibacterial, antiviral, and in this case, anti-fungal. Ll37 is the only human cathelicidin peptides with broad antimicarbid activity and immunomodulatory effects.

4:39 It is a cationic, amphipathic peptid that can disrupt microbial membranes. for instance, in bacteria, invalid viruses, and even fungi by forming transient pores leading to cell death of those microbes that are causing us harm. So it acts as an immune signaling molecule, recruiting immune cells and modulating cytokine responses in the body. And it can also induce apoptosis and Candida by membrane pore formation and intracellular ROS generation, otherwise known as reactive oxygen PC.

5:09 So it also influences host inflammation at low physiologic levels. It can chemo attract cells and promote angiogenesis, whereas higher concentrations can suppress excessive neutrophil activation. In the context of mold-related illnesses or mold exposure, So people that are exposed to mold often suffer from chronic infections, for instance, synopulmonary dysbiosis, mark on staph, et cetera, and a heightened inflammatory state in the body. So LL37's broad spectrum antimicrobial properties extend to fungi or fungi, however you pronounce it.

5:41 It exhibits fungicidal activity against common molds and yeast, including various Candida species and aspergillus. And then vitro LL37 can inhibit aspergillus fumigatus hyphal growth in a dose dependent manner, suggesting it may help control fungal load. So its immunomodulatory action could also help rebalance abnormal immune responses and chronic inflammatory response syndrome, otherwise known as CIRS. I probably say that a lot. as far as the abbreviation goes because that's a mouthful because I'm going to be talking about that a lot in this presentation,

6:15 but by neutralizing endotoxins and reducing excessive inflammation. So let's look at some evidence. There's not a lots of evidence of LO37 around mold exposure. Clinically speaking, it's going be more in the research world, But there's lot of lab studies that demonstrates its antimicrobial and wound healing. It kills fungi and bacteria by disrupting membranes and is shown efficacy against biofilms. In mice and cell cultures, it enhances re-epithelization and angiogenesis aiding and tissue repair of damaged tissue. And there are early clinical trials ongoing of LL37 for wound healing that have been encouraging.

6:49 Then a phase one and two trial in humans with chronic leg ulcers applied Ll37 topically and found significantly improved healing rates without serious adverse effects. Another trial and diabetic foot ulcer showed L 37 cream accelerated wound closure 68% reduction, by the way, compared to placebo. So we don't have any published studies specific to mold toxicity, but there are lots of doctors that have reported using it in patients with chronic infections like Lyme and mold to reduce pathogen load. Dosing information, there's not really any standardized dosing.

7:20 My personal recommendation is 100 micrograms per day. If you want to be on the safe side, you can start at 50 micro grams per So I would do 100 micrograms per day for four to eight weeks. I usually like to de-load after that because if you're exposed to too much LL-37, we do think that can be or kind of have like an opposite effect and make you even more sick. I haven't heard of anybody that it happening to because typically people are cycling on and cycling off, but I would do a hundred micrograms per day. You can do it four, six, eight weeks, whatever you see fit, and then take the same amount of time that you were on off.

7:53 But during that time, you will likely notice some reduction in the symptoms that are having, even if you only use this peptide. Now you're going to use all the other peptides I'm going talk about today. However, Even just with this Peptide, when I have done it in isolation for inflammation or anything like that, I've never to my knowledge had mold toxicity but I do love LL37 and that's typically what I did so very easy for that you would get a basically 500 or excuse me five milligram bottle to put two milliliters of water into it and then take what would that be five units so there you go Now, SS37, or I said LO37.

8:33 SS31, excuse me, so SS 31, everyone's favorite mitochondrial peptide. Maybe it's not, maybe you like MOTC, but SS-31 is a really, really amazing peptides, not just for mold, for a lot of other stuff. It's basically a mitochondria peptibe. Binds a cardiolipid and stabilizes the electron transport chain. Reducing production of reactive oxygen species in the body, so by scavenging free radicals and preventing mitochondrial permeability, transitioning pore opening, SS31 preserves mitochondria membrane potential and ATP synthesis in body.

9:03 So it acts as a potent antioxidant and energetic booster within the mitochondrion. It's also been shown to reduce cytochrome C release, thus inhibiting apoptosis. and improving mitochondrial dynamics and beyond mitochondria effects. It can also modulate cellular signaling. So for example, it activates anti-apoptotic and neurotrophic pathways by up-regulating BDF signaling in the brain. And that's just one way. Now the context of mold, is SS31 going to go search around in your body and kill the mold?

9:35 No, but chronic mold exposure and mycotoxins can induce significant mitochondrial dysfunction, which leads to the fatigue, the cognitive impairment, and poor detox pathways that you see oftentimes in mold patients. So many of these mold patients exhibit signs of impaired energy metabolism and oxidative stress in tissue. So SS-31 directly addresses this by protecting mitochondria from toxin induced damage. It also reduces oxidate stress and restores ATP production, improves energy levels, cognitive function, and tissue repair capacity in people with mold illness.

10:08 and a inflammatory mouse model that was induced with inflammation with LPS or lipopolysaccharides, SS31 preserved mitochondrial function and prevented memory impairment analogous to how it might help more related neuroinflammation or fatigue. So the very least is going to help those things for people that have mold. And then mold toxicity often involves systemic inflammation and even lipid peroxidation and SS 31's ability to stabilize cardiolipin and reduce lipids. Peroxydation byproducts could mitigate some of the toxic effects of them old. And so although it's not directly an antimicrobial, it can indirectly support detox and improves the health of mitochondria is going to prove every other

10:44 function in the body and then enhance the liver and immune system to clear micro toxins out of body itself. So when we look at clinical evidence, so it's been studied in a lot of animal models of disease involving mitochondrial injury or dysfunction. And again, in rodent studies of sepsis-like inflammation, which is endotoxin exposure, SS31 protected brain mitochondria, lowered neuronal apoptosis, was death of brain cells, and preserved cognitive function. It also improved outcomes and models, heart failure, kidney injury and ischemia by bolstering mitochondrion energetics.

11:18 And then the mouse LPS challenge study SS-31 significantly reduced markers of oxidative damage and neuroinflammation while improving memory performance. It's also being clinically developed for mitochondrial myopathies and other conditions. So human trials have shown that daily sub-q SS31 administration can improve muscle function in mitochondria disease. A small open-label trial for heart failure improved cardiac function without major safety issues. And so while no trials targets CIRS or mold, some doctors are using this and I would recommend doing so because of what it does for mitochondrial health.

11:54 So dosing wise, this is where a lot of people will lose their minds. Okay. Let me be clear. If you're using SS31 as an optimized person and you just want to bolster your mitochondrial function, 0.5 milligrams to one milligrams per day for eight weeks is a great cycle. For someone that is exposed to moles and is going to have this acute inflammation in the body, I would recommend up to 10 milligrams daily. So basically as much as you can afford daily of SS 31. Now I know that gets pricey and yes, that ends up being probably close to two to $3,000 a month,

12:26 depending where you get your SS-31 from. However, it will have dramatic effect on the body. So that's why I say as much as you can forward up to 10 milligrams per day. On the lower end, I would say five milligrams a day, but you're going to want a good amount of SS-31 on hand if you do have more toxicity. I'd say bare minimum five millimeters and then up 10 millimeters per days. And again, we're gonna do that for eight to 12 weeks would be my recommendation. Next one, you've probably heard of this and probably used it if you're watching this video, but it's going to be thymus and alpha 1. So TA1 is a 28 amino

12:59 acid peptide originally isolated from thimus tissues. It's a pleiotropic immune modulator that primarily enhances T cell function and immune surveillance in the body. It promotes maturation of T lymphocytes and it stimulates production of TH1 type cytokines while increasing dendritic cell activity. It can also bind to toll-like receptors on dandritics cells, augmenting antigen presentation and driving a more effective pathogen-specific T cell response. TA1 also shifts the immune system balance by increasing regulatory T cells to prevent over-inflammation, which a lot of times is happening in cases of

13:31 mold exposure. It's also been shown to boost expression of antioxidants and reduce oxidative stress and do damage. So overall, TA1 restores immune homeostasis in the body and a lot of times someone with a depleted immune system responds to infections more appropriately and they dampen the excess of inflammatory cascading the bodies. Again, someone who has a mold toxin overload is going to help with the immune systems. Let's look at that even further. So, mold toxicity often involves a chronically stimulated yet ineffective immune response because the immune system's been trying and trying,

14:04 and it doesn't really go anywhere. So patients can have low adaptive immunity alongside high inflammation. TA1 directly addresses by boosting immune competency against mold in their toxins. Nobly, it primes dendritic cells and enhances TH1 responses against fungal pathogens, improving clearance of molds, One review noted that it can generate a protective antifungal effect by increasing TH1 cytokines, which are INF, gamma IL-12, and others which activate phagogocytes and cytotoxic T cells against fungi.

14:40 So clinically, many mold and CIRS patients have low levels of CD4 plus T-cells and impaired response to infections. And TA1 has been used to correct these deficits of people, Anti-inflammatory and the anti-oxidant properties can help rebalance an overactive inflammatory response triggered by mold, which oftentimes looks like high TNF alpha and interleukin 6, so it can helped tamper those. It can also work in vitro models to reduce excessive inflammation in sepsis and viral infection by restoring immune regulation,

15:13 and similar modulation could benefit more patients with chronic inflammation. And lastly, TA1 may aid detox indirectly, so a stronger immune system can better eliminate colonizing fungi and handle mycotoxins. So basically it kind of bolsters the body to do what it knows to anyway, just to fight off the mold. So I say this is one of the cornerstones of treating mycotoxin, biotoxins, illnesses due to the inflammation or anti-inflammation effects. So just to look at some evidence. TA-1 is well established with decades of research.

15:43 It's approved in over 35 countries for chronic hepatitis. B and C as an immune adjuvant in some cancers. Infectious disease models that is shown efficacy to increase survival in animal models of sepsis improved clearance of difficult infections like pseudomonas. A notable study demonstrated TA1 activates dendronic cells via TLR signaling to promote antifungal TH1 immunity. So a lot more evidence around mold itself or around mycotoxins or biofilms or whatever.

16:15 Clinically, multiple trials in humans have demonstrated benefits. TA-1 improved viral clearance rates in hepatitis and reduced opportunistic infections in immunodeficient patients. in one randomized trial on severe sepsis, adding TA1 to standard care, significantly lowered mortality, specifically to mold-related illness. Literature is still ongoing, but a comprehensive 2020 review cited thymus and alpha 1's use in mold toxicity and described that it enhances TH1 and Treg responses to generate antifungal activity in the body. There are a lot of doctors that are using this and again it acts more as an immune normalizer to help the body detox itself.

16:51 Now dosage wise, it's a little bit all over the place when we look at mold toxicity. I would say somewhere around one to one and a half milligrams a few times a week, meaning three to four times per week. Some people will say two, some people say three or four. You could really do one milligram every day for eight weeks if you can afford it. This is also one that I think you could use for longer. LL-37, like I said, you want to cycle off of it, but this you can probably run for three to six months of that dose and be completely fine and only be benefiting your body. So again, use at your discretion.

17:23 But I say one to one and a half milligrams at least two, three, four times per week or as much as you an afford. The next one is going to be Thymalan. Thymalin is a bioregulator peptide, so it's derived from thymus extracts containing several short-chain peptides. So the peptids in thylamin collectively act as immunocorrective bi oregulators. Thylamides components restore normal immune cell development and communication. It also increases the number and activity of T lymphocytes and B lymphocyte.

17:55 it helps rebalance CD4 plus and CD8 plus ratios and enhances phagocytic function and macrophages. So at the molecular level thymalin peptides can modulate gene expression related to cytokine production, inflammation, and stress response. The net effect of all this is immunomodulation towards homeostasis, which a lot of times is not happening when someone has mold exposure. It also promotes tissue regeneration and hemo to hematopoiesis.

18:26 It's been shown to normalize cell proliferation and apoptosis and various organs. So basically it provides a broader thymic education immune system, somewhat like taking thiamus hormones. If you thought of taking exogenous thimus, hormones, that's kind of like what taking time one is, which is awesome. I love that one. I had a big, I mean, again, i've never had mold toxicity to my knowledge, but man, and I think I noticed Thymine sometimes more than I know is Thomas and Alpha one. And then not everyone's like that, CIRS patients often present with immune dysregulation, a mix of chronic infections, low IgG,

19:04 or subtle immunodeficiency and persistent inflammatory symptoms, so thymolines' broad restorative properties are highly relevant. So relevant by increasing T-cell counts and activity, it could help patients clear chronic fungal colonization or co-infections that the immune system was failing to eliminate. Actually, in Russian clinical use, thymelin has been given to patients with chronic infections and was shown to reduce frequency and severity of infectious episodes. Mold illness can also involve excess inflammation, so they're going to have high cytokines like TGF-beta, C4A, and thymylin's peptides have been deserved

19:39 to reduced inflammatory cytocine levels and even lower hypercoagulation markers and severe infections. patients with acute lung abscesses, adding thymalin-decreased systemic inflammatory response syndrome and normalized fibrinolysis, which is an effect potentially beneficial in mold-triggered systemic inflammation. And mold exposure often accelerates aging of the immune system and thymalin used as a geroprotective in a lot of studies in Russia was found to improve immune function in the elderly and even extend lifespan and animal models by restoring thimus dependent immunity.

20:14 So basically it helps to rebuild their immune competency and calming aberrant inflammatory reactions in body by helping the immunity system. at some more evidence that was developed and extensively studied in the former Soviet Union. Multiple studies have documented its benefits in immune-ready conditions. In pediatric and adult patients with recurrent infections or immune deficiency, it led to normalization of T-cell subsets and reduction in illness frequency. It's been used as an adjunct treatment in infectious diseases ranging from viral hepatitis to post-operative sepsis, yielding fast recovery and lower complication rates.

20:53 Notable findings in thymolins affect on acute respiratory infections. Administering it to elderly people cut their incidence of ARI roughly in half. So for chronic inflammatory diseases, thamolin showed efficacy in normalizing immune markers. Kevinson also published data on Thymalin's ability to activate hematopoietic stem cell differentiation and improve outcomes in those with bone marrow suppression. So while specific mold illness trials are not available, its peptides have been tested in allergic inflammation and stress models,

21:23 demonstrating reduced inflammatory mediators. Again, nothing there to say, hey, this has been studied in mold, but in my opinion, really good for mold. So again, dosage, if I was just running this as a cycle to overall improve my longevity and immune health, two milligrams per day. However, in the context of mold exposure, I would do 10 milligrams a day, which again can get a little pricey, probably looking at like 30 bucks per dose in that case. And I wouldn't want to do that for at least 10 days in a row, depending on the severity of exposure. So I would do five to 10 milligrams per day, 10mg on the high end and do that for at least 10 days and then maybe your 20 or 30 depending on where you're at.

21:59 So a little bit short of a cycle because of the way bioregulators work. We do them kind of in these cycles and I will use it for 10days. 10 mg for ten days, see how you feel and that's what I'd start with. From there you could resume it maybe a month or two later and you can do the same thing depending how your body is responding. So next one, probably no surprise here, but BPC-157. So everybody knows Bpc is a potent healing and regenerative effect peptide with a lot of multifaceted actions. Its primary mechanism is promotion of angiogenesis, which is new blood vessel growth by up-regulating growth factors like VEGF and its receptor VGFR2.

22:36 By increasing VFF VEDG FR2 activity, Bbc improves microcirculation and nutrient blood flow to damage tissues. It also influences the gut-brain axis and the nervous system and enhances the healing of the intestinal lining and has neuroprotective effects, partly by modulating neurotransmitters. It has been shown to upregulate nitric oxide and fibroblast growth factors, aiding in wound prepare and collagen synthesis. and it protects against oxidative stress and inflammation as well. Studies indicate it reduces pro-inflammatory cytokines like interleukin-6 and TNF-alpha in injury models and stabilizes mast cells.

23:10 And it is also cytoprotective, meaning that maintains endothelial integrity and can cataract various toxins or injuries in the GI tract, the liver, and elsewhere throughout the body. So it's prohealing and anti-flammatory. Now, in context of mold, it Mold toxicity is oftentimes going to result in chronic inflammation, poor circulation, leaky gut, and even brain inflammation. Most people with mold would say, yes, that's me. That's what sounds like me, right? So BPC directly addresses many of these issues.

23:40 Patients with CIRS have abnormally low VEGF levels, which leads to capillary hypoperfusion and organ malfunction. So BPC can actually correct the VGTF deficiency by stimulating VF and thus restoring blood flow to tissues, pretty cool. This may relieve symptoms like pain and exercise intolerance in C-I-R-S patients. Its gut healing ability is another huge plus. A mold-related illness is associated with a leaky gut, partly due to low melanocytes stimulating hormone, and BPC is well known for its dramatic healing

24:13 of the intestinal lining and ulcers, which can improve nutrient absorption and reduce systemic toxin spread from the gut. It also can help with neuroinflammation and anxiety. So it's calming effect on the vagus nerve and neurotransmitter balance can alleviate anxiety episodes triggered by the mold toxins. It's also neuroprotective. BPC has been shown to encourage neural regeneration and even reverse traumatic brain injury, especially in my case where I had a lot of concussions. And it is relevant since mold toxicity can cause cognitive impairment and atrophy of the brain.

24:45 Many more patients have concomitant mast cell activation syndrome and BPC stabilizes mast cells and reduces histamine release, though another peptide, which we're going to talk about in a second, KPV, will be even stronger. So Bpc basically ticks every box and I would highly recommend it. So when we look at preclinical studies, it accelerates healing of peptic ulcers, skin wounds, tendon injuries, bone fractures, even nerve damage, markedly improves healing in tendon ruptures. It also protects organs from toxins that reduce liver damage from alcohol and carbon tetrachloride and mitigated in said induced gut lesions.

25:20 So if you take too much Advil, use some BPC, and it will heal your gut. There are also people who have reported helping refractory conditions like fistulas and Crohn's disease, chronic inflammatory lesions, etc. And of course, there's not a lot of formal clinical trials. So we don't have clinical trial with BPC, although why would we? Because no one can make money on it, but There was a clinic I found online that reported a series of mold patients where BPC use correlated with normalization

25:50 of VEGF levels and reduction in leptin and TG-F beta inflammatory markers over a few months. So it definitely helps with the symptoms. Now dosing wise, again, it's going to be up to you. Pretty much the standard dose. I would do 250 micrograms. or 500 micrograms daily, you do 250 micro grams twice daily. You can do 500 grams, twice. Daily. That's what I would recommend injecting. you could also pair this with TB 500, which is what i'm going to talk about next. So if you wanted to do a TB, 500 BPC, one seven blend, what you're often in a one to one ratio, it would just choose, just use 250. Microgram of each and

26:25 be good to go. Or you can that twice a day, or you'd do it 500. Microgram once a. Day, but somewhere in that range. That's what I would start with. Now moving on to Thymus and Beta-4, aka TB-500. So, just as a side note, TB 500 is the name of the synthetic derivative or fragment of Thyrmus and beta-four used in therapy. I prefer TB500 because it's a version that goes to work quicker in my experience than regular, Thynus or Beta 4. Thrymus or beta 4 is great. TB is 500 great, I think TB five hundred works a little bit faster and you notice the effects a bit But just so you know,

27:01 because a lot of people are like, what's the difference? Thymus and beta-4, TB 500, not a lotta difference. Yes, there is, chemically speaking, but in practice, I like TB500 better, just my opinion. So TB4's primary role in cells is to bind to G-actin regulating actin polymerization. This influences cell motility, division, and tissue remodeling. As a healing peptide, it promotes cell migration, angiogenesis, an extracellular matrix remodel at injury sites. It also upregulates key healing cytokines and growth factors such as VEGF, just like PPC-137, and LAMIN-M5, facilitating new blood vessel formation and

27:36 epithelial cell migration. It is also has anti-inflammatory and antiphrobotic effects, so it reduces pro-flammatory cytocines like TNF-alpha, Interleukin-1, interleucin 6, by inhibiting NF-kappa-B activation in cells and conversely increases antiinflammatories cytakines, like inter-leukein 10. It also scavenges oxidative damage. Studies in the liver and the heart models show that TB 500 lowers lipid peroxidation and up-regulates anti-oxidant enzymes, and it can activate stem cells. It has been shown to recruit stem-cells to injured tissues and promote differentiation for repair.

28:09 So overall, TB500 acts as a master regulator of wound healing that helps reduce inflammation, help with the new blood vessel formation and with tissue regeneration. Let's look at that now in the lens of mold illness. So mold can lead to widespread tissue irritation and damage. We can oftentimes have respiratory tract inflammation, intestinal mucosal damage, and even microvascular injury. TB 500's broad regenerative properties make it relevant to repairing this damage so if your mold exposure has caused a chronic inflammatory state with

28:42 elevated TGF beta and fibrosis, TB500 may help reduce fibroids and encourage proper tissue remodeling. can also reduce organ fibrosis and injury models by down-regulating fibrogenic cytokines. And then in the lungs, TB 500 was shown to ameliorate inflammation and even granuloma formation, which means that it might help resolve inflammatory nodules or granulumas that can occur in mold-associative hypersensitivity pneumonitis. So for the immune system, mold patients often have an over-activation of their innate immunity with ongoing inflammatory cell infiltration.

29:17 so TB 500 can suppress excessive neutrophil and macrophage activation. Patients also with CRS often have symptoms in musculoskeletal and nervous systems. Anthymosin beta-4 aka TB-500 can aid muscle and nerve recovery. This has been used in sports medicine for muscle injuries and in neuro regeneration studies to improve peripheral nerve repair. So it can assist in recovering damaged tissues and calming chronic inflammation in the body. Just looking at some clinical evidence.

29:47 So pre-clinically, TB 500 has shown impressive results. It accelerates wound closure in skin and cornea injuries, improves cardiac function after heart attacks, and reduces liver injury and alcoholic liver disease models. In a mouse stroke model, the TB500 significantly improved neurological recovery and optimal doses. it also protected mice from lethal radiation by aiding bone marrow recovery. And on the clinical side, A synthetic gel has been in phase two trials for pressure ulcer and venous ulcers showing faster healing healing trends.

30:19 Another eye drop formulation has reached phase three trials from neurotrophic keratitis in dry eye with positive results. I have used BPC and TB 500 eye drops and they do work really well to help heal your vision. A pilot clinical trial on a heart attack patient suggests that TB 500 treated stem cell therapy improved cardiac function more than control. And so we don't have a lot of direct studies obviously with TB500 in mold, but it is going to help the tissue damage that a lot of times stems from mold. So there are a lotta people that would recommend this, I am one of them, and it's even being used in autoimmune diseases like rheumatoid arthritis,

30:54 where it showed potential to reduce joint inflammation, so it definitely works. Dosing-wise, again, the standard dose is like two to five milligrams, one to two times per week. Like I said, with the BPC Blend, you could do them in a one-to-one ratio, 250 micrograms, two time a day, or 500 micro grams, once or twice a Some people will start with a higher loading dose, for instance, four milligrams a week, one split into two, two milligram shots, and then drop down to two milligrams weekly. So this is one that I have macro dose in the past. I've taken like five milligrams or 10 milligrams of PP or excuse me, TP 500 when I'd gotten sick.

31:28 And it definitely helps with that. I think for people that are experiencing that, you could probably do a heftier dose if you can afford it, because it can get pricey. But you probably could do like two milligrams or four milligrams a few times a week and then work that up for eight to 12 weeks. If you're using it with a blend of TB 500, your still going to get good effect at that lower dose, 250 to 500 micrograms. That would be my recommendation. Next is going to be KPV, my favorite underrated peptide.

31:59 So KPB is a MSH or an alpha melanocyte stimulating hormone peptides. It's the smallest fragment of the alpha-melanocytes stimulating hormones that retains potent anti-inflammatory activity. So it exerts its effects partly through melanocortin receptors, MC1 and MC3, on immune cells, although it can act independently of some of those receptors. But mechanistically speaking, it blocks the production of ploin pro-inflammatory cytokines, so it's been shown to significantly reduce levels of TNF-alpha

32:29 interleukin-6 and inter-leucin 1-beta in inflammatory conditions. It can also intercells, interfere with NF-kappa-B signaling, thereby inhibiting the transcription of inflammatory genes, which is pretty cool. KPV also promotes the release of anti-inflammatory mediators, for instance, can elevate interleukin-10 and other suppressor cytokines to restore our immune balance. It also fosters mucosal healing, so in models of colitis, it accelerated colonic muccosa repair and reduced neutrophil infiltration. So unlike the full-alpha-lamass melanocyte-stimulating hormone, KPV does not cause pigment changes or affect the melanocytes since it lacks the N-terminal sequence,

33:06 making it a target anti-inflammatory molecule without the side effects of making you tan, like Melanotan-1. or melatonin 2. Now in the context of mold, CRS is often characterized by upregulated innate immune response, right? We have this over activation of the immune system. So KPV directly addresses this by calming inflammatory pathways. Many mold patients have what I talked about earlier, mast cell activation syndrome, and KPB is particularly noted for stabilizing mast cells and reducing

33:36 histamine related inflammation. Side note on mast-cell activation and histamines. If you get really bad rashes and hives from injecting peptides, you probably have mast cell activation syndrome. If don't want that to happen anymore, maybe you could inject 250 micrograms of KPV to stop that from happening and do that for a week and then try inject the peptide that gave you hive.

34:06 A lot of people have visceral fat that has a lot overactive immune cells in the fat. When they inject a peptide in it, it triggers those immune cell and people get really bad rashes and hives. I've never had that happen. So I wouldn't know personally, but when you look at mechanistically what's going on there, try some KPV. Just a little side note tip for you. I actually think this is probably true. There's a lot of doctors that say KPV is stronger than PPC-127 controlling mast cell degranulation and inflammation.

34:38 I think that is 1000% true, but anyway, that's kind of a rabbit hole. Mold exposure can cause gut inflammation and dysbiosis. KPB's proven benefits in IBS or IBD suggest it can help heal a leaky inflamed gut and mold patients, which is oftentimes something you have. Chronic mold illness often shows low levels of alpha-MSH, which again, KPV is going to help improve. It's essentially a therapeutic distillate of Alpha-MSH anti-inflammatory function. Using KPB may compensate for the deficiency of the Alpha MSH activity in mold patients, helping to restore gut barrier integrity and reduce excessive inflammation.

35:16 And then in any detox protocol, controlling inflammation is crucial for patient tolerance. So KPV can be used during toxin binders or antimicrobial treatment phases to prevent inflammatory flare-ups from those. And you can also take this orally. I think it's better for the gut. If you take it oraly, I would inject it for systemic healing. Now, we look at clinical evidence. There is a lot of evidence around KPVI being studied. In 2000, studies demonstrated that KPVE could treat experimental colitis effectively.

35:46 In two separate mouse colitis models, it led to faster recovery, less weight loss, and markedly reduced colon inflammation on histology. KPV worked even in mice lacking a functional MC1R receptor, suggesting some of its actions is independent of that pathway, although it might work through the MC3 receptor or have direct intracellular effects. Other animal studies have shown KPB can improve inflammatory skin conditions and reduce lung inflammation, which again, a lot of times people with mold exposure have. And we're still seeing the emergence of clinical use of KPV to heal a lot of disease and we probably never will because they can't patent it.

36:28 Dosing wise, for oral use, I'd say one to five milligrams per day, but for the case of mold exposure, i would really recommend injectable, and I would say 250 to 500 micrograms per. Day, very similar to BPC in terms of dosage. So 250, 500, micro grams, start with 250. But I think you'd be good with 500. Microgram per, day and then I, would do that for eight weeks. I use this really for 8 to 12 12 weeks probably a little bit longer and what's cool about this is you could put it with bpc and tb500 and there's even

36:59 a lot of companies now that are selling ppctb 500 and kpv together so that's pretty cool something i need to work on that by longevity lapse and lastly we have Probably one of the ones that is lesser known but more important for mold exposure is going to be VIP. So VIP is vasoactive intestinal peptide. It's 28 amino acid neuro regulatory peptides hormone with diverse physiological roles. So it works as a vasodilator and anti-inflammatory immunomodulator.

37:31 So binds to VPAC1 and VP AC2 receptors on cells, triggering cyclic AMP signaling. And then the immune system VIP generally shifts responses toward an anti inflammatory profile. so it inhibits pro-inflamatory cytokine production like TNF-alpha, interleukin-6 and inter-leucin 12, and promotes the development of regulatory and TH2 type responses. It also relaxes smooth muscles and dilates blood vessels in the lungs. It's a bronchodilator, improves blood oxygenation in brain, increases cerebral blood flow.

38:02 Another key action is that it is neuroprotective, so it can prevent neuronal cell death under toxic or hypoxic conditions by inducing neurotrophic factors. Additionally, it regulates hypothalamic pituitary adrenal access, HPA, activity and circadian rhythms in the context of inflammation. It helps correct abnormalities such as low regulatory T cells and elevated TGF beta and there is a guy named Dr. Richie Shoemaker's protocol for mold. You can google that and his research indicates that VIP is critical in recovering from CRS acting as a master regulator neuropeptide that can reset multiple

38:38 downstream pathways when replaced. So let's look at it in the context of mold. Chronic mold illness patients often have deficient VIP levels, which contribute to the symptoms of fatigue, cognitive dysfunction, chronic shortness of breath, and chronic inflammation. Replacing VIP by using it exogenously addresses several core issues in CIRS. It reduces inflammatory markers, and it improves tissue oxygenation by dilating constricted blood vessels. One dramatic benefit of VIP and mold patients is restoration of damaged brain tissues, again, which happens.

39:12 So a study using VIP nasal spray over 18 plus months found that previously shrunken gray matter structures regrew in size, corresponding with cognitive improvement. And then clinically, VIP helps alleviate refractory symptoms. Patients report better energy, clearheadedness, improved exercise tolerance, and normalization of temperature regulation and thirst. Moreover, it has a role in pulmonary health, so many mold patients have reduced exercise capacity, or pulmonary hypertension, and VIP is a pulminary vasodilator that can relieve these issues.

39:42 It also can help with chronic nasal congestion by reducing inflammation and nasal mucosa when used as a spray. So it basically is crucial for resetting the chronic inflammatory response and mold toxicity once other steps like toxin removal are done. So let's look at this. This guy, Dr. Richie Shoemaker, did a lot of work on this, an open-label trial of 20 patients with refractory CIRS due to water damage buildings. Intranasal VIP for at least 18 months led to significant improvements in their lab work.

40:16 All patients had resolution of their remaining symptoms. Their visual contrast sensitivity normalized, inflammatory markers fell to control levels, and MMP9, which is indicative of blood brain barrier permeability, normalized. Brain scans also showed increased gray matter volume after VIP, suggesting true recovery of the brain tissue. And then no adverse effects reported aside from transient nasal irritation, just from shooting the peptide up their nose. Another published report documented that after VIP treatment patients, neuroquant MRI abnormalities were corrected in transcriptomic abnormality and white

40:50 blood cells shifted toward normal. Beyond most specific data, VIP has been studied in other conditions, so it's protective. In some models of pulmonary fibrosis and acute respiratory distress syndrome, reducing inflammation, improving oxygenation, small clinical trials, and sarcoidosis, which is a granuloma. Granulomatois disease showed promise in lowering inflammatory cytokines using VIP analogs. And because VIP is a neuromodulator, it's been researching cognitive disorders. For example, studying Alzheimer's models indicates its neuroprotective effects and all of these support the rationale for VIP's use in CIRS.

41:25 So again, definitely more of a powerful one for mold toxicity. This one is actually, I haven't found a lot of people that inject this one because it's built to be more of a nasal spray. So the standard concentration is 50 micrograms per spray, so the recommended dosing is 15 micro grams and one nostril four times a day for a total of 200 micro-gram per day. What you would do is you'd get a five milligram bottle of VIP.

41:57 And in this case, what I would because a nasal spray, let me do some public math off the top of my head real quick. A nasal-spray pump typically gives you 0.1 ml. So if I want 50 micrograms for every 0,1 pump, what I'm going to do is add five mls of water. So you're probably going have to pull it out of a three ml vial if the vile is not bigger than three mlls and put five ml of the water into it. And then when I do that, that's going make it one milligram per milliliter to which if I I guess one tenth of that that would be a hundred micrograms.

42:34 So I guess you would want 10 milliliters of water. So 10 mililitres of will give you 50 micrograms per nasal pump spray. But if you did five, you get 100 micro grams out of one pump, so you could do two pumps to get 200 micro-gram. Anyway, that's pretty easy. You just get saline solution to mix the peptide in that case and you spray it up your nose. Some people use backwater too. Hey, I don't like it. It burns. But that's what I would do to make the peptide into nasal spray. So again, 50 to 200 micrograms per day intranasally is what you would want to use with VIP.

43:10 Now I have, as promised, the slide for everyone on there. So let me make my video really small and have this on here. If you want to screenshot it, that is the slides with the doses and the explanations for everything on their. There you go. That is it for the sides. And there you have it. This is my comprehensive video for the mold toxicity exposure that you may be going through with peptide.

43:42 So hopefully that was helpful. It's pretty in depth, but it's been one I've been wanting to do for a while. Again, a lot of these mimic what I would say for autoimmune disease because a of the side effects for Autoimmune Disease are very similar to mold, toxicity. However, there's a couple in there, particularly the VIP that I recommend to help with the more exposure. I think if you use these in the recommended fashion that, I say really, with testosterone optimization, these peptides, healthy diet,

44:12 a healthy lifestyle. I think people can really reverse mold exposure in 12 months doing this, if you're using these over the time. So can't guarantee that, but I really do think these would move the needle massively in the direction of helping people heal. And that is my goal with this. so I would love to hear your thoughts. If you had molded exposure and you used all these peptides or any of thesepeptide and they worked, I'd loveto hear that in comments just so other people see that. so they can see these work and then go find them for themselves and research on their own with them. But I think that's becoming something that I realize is much more important now is like, when people hear me say it, they understand it.

44:45 And then when I see other people, like it works, it's like okay, I can use this. That really is the goal of this, just to help people heal from these things. Mole toxicity is so prevalent. I'd say it's probably one of those things the majority of people that have it probably don't know they have. Whereas like, you know, with a broken arm, everyone knows they had broken arms, right? So they know what to do. With mold exposure, a lot of just are ill. They have this chronic fatigue or they inability to do anything during the day because they're so sick. And a lot of times this could be mold exposure or the damage that resulted from mold exposures to the rest of the body.

45:16 So that was the goal with this one. But again, I look forward to your feedback. Thank you. Thanks you guys so much. I am all overwhelmed with the amount of support. The amount gratitude I have is so that I get to this every day. You guys don't even know. To thank you so for all the people supporting the channel, like, comment, subscribe, sign up for the email list, buy the products, all that good stuff. Love you, guys, so thank for everything. that you do to support me from the bottom of my heart. It is a dream come true to get to do what I do. So thank you guys and I will talk to you in the next one. Peace.