Peptide Replacement Therapy: Restoring Endogenous Peptides as You Age

0:09 Hey everybody, this is Hunter Williams. I hope you were doing amazing wherever you are at in the world today. Today's video is going to be something that's a pretty cool concept that I would love to see take more foothold in I have to give credit where credit is due. There is an amazing doctor. Her name is Dr. Elizabeth Yearth and I was recently on a panel with her at the Olympia in Las Vegas. It was called the Olympic University and it's an education piece that the olympia does that they have there for people that are attending the expo.

0:45 And we were talking about peptides and we're talking all these different peptide, you know, the cool, amazing peptidies that we all love. And she actually brought up this concept of, hey, a lot of these peptids are endogenous and just like we replace hormones, why are we not replacing some of this endogynous peptidae that fall off a cliff as we age? And it really got me thinking, man, she's right. So what I want to do today is put together a video of the peptides that we actually have endogenously in our body, because some of peptide we talk about are endogenous, meaning they're made by the body and they are naturally in the bodies.

1:17 Some of them are not. So retitrutide is not in your body naturally. But there are ones, like MOTC is actually endogeneous to the bod. And we can track levels of these peptids as we age, and a lot of times they actually massively declining. And again, if we talk about replacing hormones to be a therapeutic level to help us stem the tide of aging, why not peptides? Today, I want to walk through and make the case of, hey, just like we replace hormones, we can replace some of these peptide. And I'm gonna walk though some, the peptidies are actually in our body naturally and how they decline over time with age and we how we use a lot of this

1:55 in the background at different times throughout the year just as part of an anti-aging protocol. So I'm not going to have like one giant protocol that you can do this. This is more the introduction of the concept to understand which peptides are endogenous. And again, there's more that are not on this list that I might talk about, but how we can use them to benefit as we age to, have healthy levels that, are going then allow the body to do what it naturally needs to because When we were younger, we had these peptides in abundance. That's what today's video is going to be about. Before I get into it, make sure that you run the email list.

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2:58 All right, thank you guys so much. I have the best audience in the world. Without further ado, let's talk about peptide replacement therapy today. Alright, I'm Hunter Williams and today we're going to look at peptides replacement therapies for healthy aging. What I wanna do is I put together 14 endogenous peptids, meaning that they are naturally in our bodies and actually how we can use synthetic analogs of those to assist in graceful, beautiful, lovely aging, Let's look at IGF-1 first, probably one of the more common peptide classes that are used.

3:32 And we talk about IGf-I, basically we are looking at the class of growth hormone peptides. Obviously there's IG-F1-LOR3 that we could use as a peptid, but there Tessamerella and there is Ipramorella, and their CJC-1295. There's human growth from on itself. Basically IG1 is produced mainly by the liver in response to growth hormones, which promotes cell growth. protein synthesis and tissue growth in muscle, bone, and the brain. By age 20, IGF-1 levels have dropped by about 40 to 50% of our adolescent peak levels.

4:04 And by age 60, levels are about 50 percent lower than they were in our 20s. By restoring IGF-1 through the variety of means that I just talked about, it can counteract sarcopenia and frailty, and animal studies have shown improved muscle mass and function in older organisms. But just be warranted or caution is warrant it around excess IG-F1. It's not always the best thing to do. I think when we talk about replacing it in a therapeutic dose, is something that's very healthy. But the concept remains the same is that IGF declines with age.

4:37 We can either use a peptide to naturally stimulate the pituitary to make more growth hormone, which then gets converted into IG F by the liver. we can use exogenous growth hormones to raise IG f1 to therapeutic levels, or we could use IGf1. I think that would be more of like a specific use case that you would want to do that. But by raising HGH, we thereby raise IGF-1 and it helps us with muscle mass, burning fat over time. And again, it's something that we can easily manipulate to get good effect. Thymosulfo-I, people oftentimes don't realize that this is actually in the body.

5:11 It's a 28 amino acid peptide from the thymus gland that promotes T lymphocyte maturation and enhances immune cell function. and blood levels beginning declining as early as age 10. And by age 50, thymic hormones have plummeted as the thimus shrinks and is replaced by fat. So yes, our thimas shranks over time. TA1 is actually proven in some countries as an immune boosting adjuvant. It enhances T cell numbers, improves responses to things that were exposed to the environment and reduces mortality and severe infections.

5:41 And thymacin alpha-1 therapy can reverse aspects of immunosenescence, restoring an older person's immune profile to a more youthful state. In a lot of cases, with all the autoimmune disease, all of the different sort of sicknesses and everything that are out there that have plagued the world so much, as of late, thymosin-alpha-one works amazing. And a lotta times, people don't realize that when we're using it, we are actually replacing a peptide that is naturally in the human body. Again, I think thimacine alpha 1 Even if you are a healthy individual already, it can be a peptide that you run cyclically throughout the year and get

6:17 really good effect. Obviously you can use it acutely to help with viruses and things of that nature. We have thymus and beta-4 also called TB-500. Thymous and Beta- 4 is the long peptide. TB 500 is a fragment of that peptides that is synthetically made. You can get either from multiple places if you're getting it in the research world, but thymus and beta-4 is 43 amino acid peptid ubiquitously distributed in tissues primarily functioning in tissue repair and regeneration.

6:48 It promotes cell migration, angiogenesis, which is formation of new blood vessels and tissue remodeling after injury. I used some yesterday actually because I felt like I pulled a muscle in my back at the gym and boom, within a few hours, man, my backwards feeling great again. I love thymus and beta-4 aka TB 500. They're not the same thing, but for the intensive purposes of talking about supplementation, we'll just call them that. But it basically reduces inflammation at wound sites, promotes formation of new blood vessels. It also helps lay down collagen for healing. And as the thymus basically shrinks with age, overall output of thiamic peptides, including thimus and beta-4, significantly reduces,

7:25 and also aging tissues produce less thимus than beta 4 in response to injury compared to young tissues. We also have evidence to suggest in mouse heart attack models, thimosin beta four significantly reduced cardiac damage and improves repair with no side effects. You also improved eye healing, and side note you can also make TB 500 eye drops and I think that's actually an FDA approved drug but also we have enhanced tendon repair and reduced kidney fibrosis in a lot of cases.

7:55 So TB 500, an amazing peptide. And again, as that thymus gland shrinks, it's going to be one that we produce less of with age that, we can actually replace. We also have thiamine. I love thamine and in lot cases, I would even recommend thialine over thimus and alpha one, but basically it is a fractionated polypeptide complex extracted from our thimas gland. Again, again you see the thimasu gland shrinking really has some pretty big effects on the body, but it contains a mixture of thymic peptides that collectively regulate immune function. It acts as a thiamus gland substitute, basically providing hormonal factors of a young thimus that the thimas would normally secrete.

8:32 So we have two to two and a half times reduction in infections with thymalin use. We have 50% lower mortality in the death rate in thylalanine treated groups versus untreated groups after six to eight years. And we had a combined effect with lower mortality rates when combined with epithalon over six years, so epitalon, which we'll talk about in a second, actually amplifies thylon. But basically studies from Russia showed thymalin therapy, improved immune function, metabolic and cardiovascular markers, and even extended lifespan and the strong safety record across thousands of patients in Russia demonstrates minimal side effects.

9:07 With repeated courses over years, again, I love thimalin. I usually run it at least two months out of the year on two different 30 day cycles, but thimon is great. And again as our thiamin gland shrinks with age is something that we can really stand to benefit from. KPV, a lot of people don't realize KP is an endogenous hormone, is a tiny tripeptide made of lysine, perylene, and valine derived from the alpha melanocyte stimulating hormone with powerful anti-inflammatory and antimicrobial properties. It also inhibits NF kappa B signaling, reducing pro-flammatory cytokines, and the melanocortin anti-inflammatory tone is greatly diminished by old age,

9:44 specifically as we get into our 60s and 70s, which contributes to chronic inflammation, otherwise known as inflammation. But we see benefit to oral KPV and colitis models with gut issues. I love oral KP for that. It also protects the skin from pollution induced oxidative stress. And also helps with wounds. KPB is really probably the most underrated peptide out there, I think. What I like about it is that everyone wants to use BPC and TB 500 for tissue repair and wound healing, which are great, but if you don't suppress the inflammatory

10:18 environment in those areas, it's not going to work as well. And what KPV does a really good job doing is healing the inflammation environment and suppressing those inflammatory cytokines. That's why it works so well for so many different things. We also have Huminen. This is another mitochondrial peptide endogenous to the body. It's a 24 amino acid mitochondria derived peptides that functions as a cytoprotective or cell protective signaling molecule, basically protects neurons from oxidative stress, enhances insulin sensitivity and promotes cell survival under stress conditions.

10:48 I would say in practice, humanin is more of the mitochondrial peptide that works really well for the brain and works well in protecting those brain cells. But by middle age, most people have a 50% decline in human than they did when they were in early adulthood. And also children of centenarians, although this is funny, had higher human in than age match controls. Typically they had twice the level of human and peptides in their body than people that did not leave to be 100 or parents that do not live to 100. So

11:21 I thought that was interesting when we look at the centenarian world, but we looked at therapeutic benefits. Mice over-expressing human end showed improved insulin sensitivity and better memory. Human analogs improved metabolic health and delayed cognitive decline in middle-aged mice, and it also protected against macular degeneration and heart disease in models. And again, to go back to the brain, I would say if there was one peptide for eyesight, SS31 is great, but also human N is also great for eye sight as well. Again, it's a natural peptides with an excellent safety profile. Mice over-expressed in human develop normally with only positive results of having the over expressed human.

11:54 There's no evidence of promoting the C word or unwanted proliferation of the T word. MOTC, another, excuse me, mitochondrial peptide. This is gonna be more for our metabolism, but basically it's a 16 amino acid peptides encoded in the 12S RNA region of mitochondria DNA translocates to the nucleus under stress and modulates genes involved in our metabolism. And it also functions as an exercise mimetic, which means that it enhances insulin sensitivity and promotes glucose utilization and muscles and kind of

12:24 simulates exercise. But studies show about a 21% drop in circulating MOTC by the time we're in our 70s and 80s compared to individuals in their 20s, which is not huge compared some of these other ones, but it's still pretty significant. And this decline contributes to age-related metabolic slowdown and reduced exercise capacity, and elderly mice given Motsy injections roughly doubled their running endurance on a treadmill and the peptide reversed insulin resistance and improved glucose control in old mice. To my knowledge, there's not really any studies of MOTC supplementation in humans, but time and time again in practice, it seems to work really well for

12:59 people and is one of those awesome peptides I think everyone should have access to and use regularly. In the same vein of the mitochondrial peptide, we have SS31. It's a synthetic tetrapeptide designed to target mitochondria. it concentrates in the inner mitochondrical membrane where it binds to cardiolipin, Stabilizing the cristae and improving electron transport chain efficiency. I always say if MATSI is the software remodel, SS31 is a hardware remodel. But in eight weeks of treatment, it's substantially reversed cardiac aging in 24-month-old mice.

13:32 Their hearts pumped almost like young hearts. An eight days of treatment increased running endurance of old mice improved muscle fatigue resistance and a single IV dose improved mitochondrial ATP production in older adult muscle biopsies. It's also now FDA approved for Barth syndrome, which is a mitochondria disease. And by age 70, many tissues have 30 to 50% less ATP output than in youth and mitochondrial dysfunction underlies fatigue, sarcopenia, and organ decline. And SS31 compensates for this age-related biochemical deficit.

14:04 Basically by enhancing the electron transport chain, we're going to enhance the ATP input, which is going help with energy levels and ultimately mitochondria function in the whole body. It's very safe. Again, it just got FDA approval and even at super high doses, We don't see any downside to it. We also have glutathione. Glutathion is a tripeptide found in every cell, often called the master antioxidants. This can be our big antioxidant defense. It protects cells from oxidative damage, detoxifies harmful compounds and supports immune function.

14:35 We have 35% liver decline in glutothione in 24 month old rats versus three month, old young rats. So we obviously have a massive drop-off in the glutathiol levels as we age. And obviously, depending on how much stress we are put in our environment, it could be more or less. We also have lower glutathione blood cells of 70 year olds versus adults in their 20s. And again, so we're seeing a 20 to 30% decline in the amount of glutothione and bloods cells over a lifetime from young adulthood to old adulthood. Apitalin, a lot of people don't understand that this one is also endogenously produced.

15:10 Basically it stimulates telomerase enzyme in human cells, elongating telomeres by approximately 33% on average. It also normalizes melatonin production and circadian rhythms in older organisms. And also acts on gene regulation. So it acts as a bioregulator, which modulates gene expression relating to aging and immune function. When we look at epitalon, it's going to be closely correlated with melotonin in production, and meletonin levels at night in an 80 year old or only a fraction, sometimes less than 10% of those in a teenager, which is a 10-fold decrease in pineal output.

15:42 And in a 12-year human trial, those receiving epitalin had significantly lower mortality, death rate, approximately one-third of the control group, and one year treatment increased telomere length by 30% to 40% in blood cells. I always tell people epinalin is not going to be one that you necessarily feel, but it is going be that does us good for the long term. That's why I think a couple of times a year or even just once a Oxytocin, another one is great. It is more than just the love hormone.

16:14 Obviously it's known for that, but it also helps with muscle building and fat loss. But oxytotin is a nine amino acid peptide known as the bonding hormone, it but also plays crucial roles in muscle maintenance, regeneration and metabolic health. Old mice given oxytoxin healed muscle injuries around the capacity of 80% of young mice versus poor healing and untreated mice. Oxytocin also lowers interleukin-6 and TNF-alpha levels, which counteract chronic inflammation common in elderly people. It also reduces abdominal fat and improves insulin sensitivity in animal and human studies.

16:48 And also circulating oxytosin drops in old age. Aging tissues have fewer oxytocin receptors on the muscle stem cells and blocking oxymocytosis in young mice made their muscle healing as poor as it was in old age. So we know oxytocin is definitely doing something there. Obviously pretty safe. Just keep the dosing low. If you're just starting it around 50 to 100 micrograms. Kissed peptin, a lot of people don't realize kiss pepton is actually an endogenous peptide. It's a neuropeptide hormone that stimulates GNRH release from the hypothalamus, which triggers the cascade that produces testosterone in men and estrogen

17:22 and progesterone in women. Basically, it's almost like a gatekeeper of reproduction. Basically kiss-peptine neurons activate, then GnRH is released from the hypothalamus, the pituitary then secretes LH and FSH, and then gonads produce sex hormones. And the kids' peptin-1 gene expression in the hypothalamus decreases in advanced age and plasma kids peptide peaks in late adolescence and falls by midlife and older men have blunted LH responses to kids peptin. And again, kids-peptide administration increases L-H NFSH secretion and in men infusions cause robust rise in L H and subsequent testosterone increases.

17:59 Again, the half-life of this one can be kind of weird depending on how you administer it, but it offers physiological way to boost sex storage while maintaining fertility, unlike direct hormone replacement. And I think even for guys on hormone replacements, when I started researching this, I was like, man, maybe there's a place for kids pepped in sometimes throughout the year to be able to just replace the natural decline that we have. We have BPC, obviously that's found in human gastric juice. It's a 15 amino acid peptide isolated from human gas reduce. We had angiogenesis, so it stimulates formation of new blood vessels to support healing.

18:32 we have growth factors that upregulates growth hormone receptor expression in injured tissues. And then it also acts as an anti-inflammatory by reducing swelling and pain, modulating nitric oxide for proper blood flow. Also in animal studies, Bpc accelerated healing of gastro ulcers, skin wounds, tendon tears, ligaments, In ligament injuries, broken bones and nerve damage in rats with transected Achilles tendon had dramatically faster healing and stronger tensile strength. And again, as we age, it's harder to necessarily track person to person how much BPC declines, but we know that using it does have good effect when we're

19:05 using for the right reasons. Then we have GHK. So we endogenous GH K in the human body. GHK stimulates collagen production. It promotes angiogenesis like BPC does. Also helps with gene regulation. That's where it's really powerful and stands out and shines. But we have dramatic reduction in GHk levels as we age. So in young adults, plasma GH K is roughly about 200 nanograms per milliliter. And by age 60 or 70, it drops by more than 60%. And elderly individuals have only about one third of the levels that people have in their twenties.

19:39 BeyondSkin GHK inhibits lung fibrosis, promotes nerve regeneration, resets gene expression to more youthful profiles and liver cells. It also stimulates bone blood vessel formation. Again, I think when we look at GH K there's absolutely a use case. if not once, at least multiple times per year to use it. And when we look at these, all these endogenous peptides, we see common patterns, right? We see declines in the immune system as we age. That just happens to everyone. We, see decline in muscle as age, that happens everyone, decline and skin quality and the tissue quality of our body decline as,

20:16 and we, mitochondrial function. When we talk about replacing peptide, or really addressing these four areas that are outside of like the hormone replacement, realm that we can improve and add benefit to our body by replacing. So the multifaceted degeneration is akin to a complex orchestra losing its musicians. Hormone replacement therapy has taught us that restoring a missing signal can dramatically improve health and quality of life. And peptide replacement, maybe we'll coin the phrase PRT, is an extension of this concept to broader set of signaling molecules that govern aging.

20:52 Now, why would we do it? We have parallel declines and dysfunctions as we age. Following peptide levels correlate with specific aging phenotypes and restoring the peptid class can reverse or mitigate the dysfunction. We also have holistic rejuvenation. So these peptides have broad system effects and crosstalk. Thymacin alpha-1 does more than boost immunity. It also improves metabolic cardiovascular and nervous system outcomes, also multi-organic benefits from sickle interventions. Most of these, if not all of them, are extremely safe and you can replace them at the therapeutic doses we're talking about with really no downside,

21:29 say almost no down side. We also have a physiologic balance. The goal is to restore levels to healthy young adult ranges, not overshoot unnatural territory. And as long as you're staying within the dosing parameters that Most people in our world will talk about you'll be completely fine. And there's also even human evidence with some of these peptides that show reversing biological age, particularly epitalon. Then you combine that with these other ones, it's going to help a lot. Epitalin and thymalin. But basically, I think this is the future of just saying you know, let's look at replacing peptides, just like we're replacing hormones.

22:02 And hopefully using some of these agents becomes so commonplace that it's completely normal, as it would be for you to get testosterone from your doctor to, get epitalon, MOTC, SS31, humanin, oxytocin thymosalpha-1, and be able to to some these. Is that what will happen? No, but I think you could make a very strong argument for it. To age better, consider aging peptides better. Replacing the lost peptide is a natural targeted and promising strategy to maintain the vitality of youth far into our later years.

22:34 And I think that's where we go from here. That is it for the slides. and that is my case for peptid replacement therapy. I know if you're watching this, most of you would probably agree because you've likely experienced firsthand some of the benefits that pepti can provide to your life. But the goal in doing this video was to really introduce the concept. But then also, I think a lot of us, we get lost in the weeds of all the new peptides and GLP-1s and everything, and those are great and they're amazing interventions and drugs that we have access to.

23:04 Even if you don't want to have these super strong signaling molecules like a GLp-I, there's still a place to replace peptides as we age. And for someone that might be a little bit skittish, you could share this with them and say, hey, look, did you know that matzi levels drop by 20%, that human levels decrease by 50% as age, that oxytocin levels fall off a cliff, then we can actually use analogs of these as therapeutic peptide to restore our levels to a healthy range to basically extend life and not only extend live, but also improve our health span and improve how we feel.

23:42 It's amazing that some of these peptides, as simple as like an SS31 or a MATC, it's simple and as affordable they are. People don't realize that even just getting something like that, just having that one peptide, the systemic effect it can have on multiple organ systems in the body can create such positive change that it gets them going in a right direction to move away from chronic pain or chronic fatigue or sarcopenia or whatever it is. And again, these are out there now. Hopefully we can make this more mainstream and acceptable. That's obviously my mission is to help do that.

24:12 But I would appreciate your feedback on this one. I love you guys so much, I have the best audience in the world. Let me know what you think of peptide replacement therapy. And if this kind of shifted, you're thinking, because I think a lot of times we use peptides for acute issues, fat loss, healing or whatever it is, but sometimes we forget that a lotta these can be used just like supplements, just my vitamin D or just, like, my fish oil to be use at multiple times throughout the year, not necessarily for an acute issue, although they can't be useful for that,

24:45 But just to help with healthy aging and making sure that I'm healthy for the long term. That's it for this one. Again, thank you guys so much. I am overwhelmed and have gratitude for the amount of people, especially in light of recent censorship on social media that has taken place that are supporting me and everything. So again, anytime you use my code anywhere, sign up for email list, help share the videos, I would say like, comment, subscribe, but I'm not on YouTube right now. All those things, uh, can't tell you how much Gratitude I have and just my heart goes out to all you guys that support that and hopefully these messages

25:20 that I bring you also bring joy Entertainment and education to your day. So that's it for this one. I appreciate you. Guys. Love you, guys, and I will see you the next one peace