Saturday Morning Coffee Talk · 2/7/26
Saturday morning before the Super Bowl, Taylor and I jumped on a live to talk through what's been on my mind this week and answer your questions. The big one for me right now is the absurd amount of medical gaslighting happening to women trying to get hormones. I also got into MK-777, cholesterol on TRT, and a bunch of other stuff. Here's the rundown.
Women Are Getting Gaslit on Hormones
This week I emailed my list about a project I'm building. A platform that matches people to the best hormone doctor for them. I got hundreds of replies. The stories were eye-opening.
The amount of women being told by their doctor that they don't need testosterone is staggering. Either they're told they only need estrogen and progesterone, or they're told injectable testosterone for women doesn't exist. Which is just false. Compounding pharmacies make it. I've got my wife on it.
A lot of doctors will tell a man cream is better because it raises DHT and helps with that masculine drive. Then a woman walks in and gets prescribed cream too, even though for her that means more DHT, more acne, more hair loss, and less aromatization to estrogen. The cognitive dissonance is wild.
In my experience, most women do well on injectable testosterone alone because it saturates the receptors better and aromatizes enough estrogen naturally. Then doctors don't have to stack on extra estrogen scripts.
We're also seeing a lot of perimenopausal and premenopausal women getting prescribed estradiol when they don't need it yet. Most of them need testosterone. Then they blame progesterone for the bloating and spotting when the real culprit is the estradiol they shouldn't be on.
If you're a doctor who prescribes hormones the right way, get on my email list and reply. I'm building a roster.
A Peptide Review Hub Is Coming
Another project I'm working on. A central place to read verified human reviews of peptides. Right now if you want real user experience on something like VIP, Velon, or Cartilax, you have to dig through Reddit or sketchy Discord groups full of people trying to sell you stuff.
Imagine an Amazon-style review site for peptides themselves, not tied to any vendor. 17,000 verified reviews of FOX04-DRI would tell us a lot about what people actually experience. That's the goal.
MK-777 vs MK-677
Jake asked about MK-777. There's not much research on it yet. I've used it on myself and so has Taylor.
The difference from MK-677 is that 777 doesn't raise cortisol or prolactin, doesn't spike appetite, doesn't cause water retention, and doesn't seem to cause insulin resistance. MK-677 works great for raising growth hormone but the appetite spike, prolactin bump, and cortisol rise make it tough to run long.
For me, MK-777 felt almost identical to ipamorelin. I slept better, abs looked harder and more defined, heart rate was lower, HRV was up. No water retention. I dosed 10 mg before bed, Monday through Friday, with weekends off.
I'd run it 4 to 8 weeks at a time. We don't have long-term data yet. You could also stack it with growth hormone, doing GH Monday/Wednesday/Friday and MK-777 Tuesday/Thursday for the natural pulse.
Subcutaneous vs Intramuscular Testosterone
Savannah asked why Taylor injects intramuscular. Intramuscular hits the bloodstream faster and more completely. Sub-Q metabolizes slower and sometimes doesn't fully convert.
A lot of women think IM means a giant needle. Use a 28 gauge half-inch into the delt. It hurts less than a 31 gauge in the belly because women have more nerves in the abdominal area. Try both and see what works for you. I have a 30-minute video on Spotify going deep on this.
Hematocrit and Cholesterol on TRT
Most guys panic when their hematocrit hits 50. People living at high elevation run 57 or 58 and are perfectly healthy. I sit at 50 or 51 and I don't worry about it. I get concerned when it's in the 60s.
Don't donate blood reflexively. You'll tank your iron and ferritin and end up anemic. Do cardio every single day. Thirty minutes minimum, plus 10 to 15k steps. Almost always that solves it.
For cholesterol, I'm not a cholesterol expert. But if you're controlling body fat and inflammation, cholesterol becomes much less of an issue. GLPs help. SGLT2s like Jardiance help. Citrus bergamot can improve HDL. Statins are not where I'd go.
Cerebrolysin and Brain Health
Someone asked about P21, Cerebrolysin, and Dihexa for memory and recall.
Dihexa is the entry point. P21 is intermediate. Cerebrolysin is advanced. I think Cerebrolysin should be reserved for once-a-year cycles, or for stroke, TBI, concussion, or early dementia cases.
Honest take. A lot of people asking about brain peptides really want Adderall. They want to sit at a desk for 15 hours and be in the zone. That's not normal human behavior. At some point you pay the piper.
When you're hormonally optimized, sleeping well, training, and your diet is dialed, your memory and recall are already good. Most people skip the foundation and want a peptide to fix it.
For cognitive sharpness without the heavy dose, look at lyophilized cerebroprotein hydrolysate. Around 20 mg before bed. The pre-mix Cerebrolysin at 1000 to 2100 mg is overkill for most people just wanting a boost.
ATX 304
I love ATX 304. Better long-term option than SLU-PP-332 or BAM15 in my opinion. No burnout feeling, good cardio sessions, lean and defined.
The catch is dose. You need 500 to 700 mg to feel anything. A bottle of 30 caps at 100 mg runs about $300 and lasts a week. That's $1,200 a month. Not realistic for most people. Until the price comes down it stays cost-prohibitive.
It's an AMPK activator, so it sits on the longevity side, not the muscle-growth side. Don't take it around weight training. It'll make you feel weaker. Use it before cardio or in the afternoon.
SLU-PP-332 Dosing
Start at 250 mcg per day. Work up to 750 mcg or 1 mg max. Don't chase a big overwhelming feeling. If you're feeling it that hard, you're going to build up reactive oxygen species and pay for it later.
Important point. Heal your mitochondria first with SS-31 and MOTS-c before running SLU. SLU amplifies whatever state your mitochondria are in. If they're unhealthy, you're amplifying the wrong thing.
Estradiol for Men on TRT
I take 1 mg of injectable estradiol cypionate per week sometimes. For guys who don't aromatize much, it improves sex drive, lipids, and overall well-being.
Doctors will tell you injectable estradiol doesn't exist. It does. Empower Pharmacy carries it. You may need to source it underground because most providers refuse to prescribe it.
Sleep Stack
Growth hormone peptide first. Epitalon has been getting me into deep sleep lately. I'm not getting up in the night at all. Dream Catcher spray from Soma works well. Add a gram of magnesium.
Taylor adds journaling before bed and reading fiction. Color puncture therapy has helped her nervous system a lot. Don't skip the foundation stuff just because peptides exist.
Testosterone: The God Molecule
Leo asked where the book title came from. When my total testosterone was 80 to 100 ng/dL, I was depressed, anxious, and questioning why I was on the planet. Fixing it brought me back to myself.
For me, testosterone was the closest thing to a real-life red pill. Once it's fixed, the way you see the world changes. That's where the title came from. Read the book and you'll see it's not a religious thing. It's about how solving that one problem changed everything for me.
My take
The hormone landscape for women is broken and most providers don't know what they don't know. That's why I'm building what I'm building. On the peptide side, MK-777 is genuinely interesting and feels like oral ipamorelin in my body. ATX 304 is great if you can afford it. And the foundations still matter more than any stack. Sleep, training, diet, hormones dialed in. Get those right and most of the questions answer themselves.
Thanks for hanging out with us on a Saturday morning. Without you, none of this exists. Enjoy the Super Bowl, eat a little junk food, take your peptides, and you'll be fine.
Full transcript click any paragraph to jump video
Good morning. And we are live. Good Morning, everybody. Hope you're doing amazing. Today is Saturday, February 7. Saturday before the Super Bowl. If you guys could just in the chat, let us know if you hear us. Okay. Yeah, if You can hear both of our mics. Usually my mic is the problem. Yeah, sometimes there's a problem with the mics not picking up. So hope everyone is doing well. Hope you guys are enjoying your Saturday wherever you're at.
Awesome. Thank you, Jake, coming in. We'll let some people come in and if you want, just go ahead and post your questions in the chat. we will make sure we cover all of your I think kicking off, Taylor and I were kind of talking about what we want to talk about this morning. I just in terms of rant that I wanted to do was about hormones and If you're on my email list, you know this week that I'm working on something of basically
like a platform that will match people to the best hormone doctor for them. Turns out this is like much more of a massive problem than even I expected to see. And I got several hundred email replies, like in the high hundreds of email, replies that people sent to me and said they were interested. So that's a good thing. but it was so enlightening to me to see the problems that people struggle with when they go to their doctor in order to try to get hormones.
I think for me, what I realized from the responses that I got from people was how bad women get medically gas lit from their doctors. The amount of women that, I received emails from that said that they were told by their Dr. That they don't need testosterone. either that they don't need testosterone or that the only need estrogen and progesterone, that don' need to testosterone, they only estrogen progeterrone, which just makes no sense if you think about it biologically. Like I'm not even saying I have like the best method of hormone therapy.
I know what can work, but I either heard a lot of stories of women getting told from their doctors, They don''t need testosterone or there were only certain delivery methods of testosterone that women can take and that injectable was not one of them. Literally doctors telling people that you're not allowed to have injectible testosterone for a woman, or that they don't even make injectble testosterone, which is not true. That's what compounding pharmacies exist for. And so for Arant, I think for me, it's one those things and hopefully the project and the company I'm working on to build with this help solve this issue
because it's a massive issue is just getting people access to the hormones that they need to have access too. So that was one thing that for me was like wow and I really feel some of the messages I got from women it kind of it breaks your heart a little bit to see the struggle that a lot of women especially after the age of 40 go through because they get told that nothing's wrong with them or that their testosterone is perfectly fine and they don't need testosterone. And so it's really tough to see that, but that's why I'm working on what I am working and hopefully as we go through this year,
it will become much more streamlined. Right now, we're just kind of putting some beta users through the experience to make sure they get matched up. But I will say if you are a doctor that prescribes hormones and you happen to be listening to this, please reach out to me because we are actively building a roster of doctors that do HRT, BHRT the right way. And I had a good amount of them reach out to me and hopefully we'll be setting up meetings with them and, hopefully, bringing on board. But that's the plan to do. One thing, it really makes you feel...
I never thought when I got into this that I would be helping a lot of women. When I was in my 20s, that was the last thing I thought. I would be doing, but thankfully through divine fate and whatever you would call it, you know, and being on this journey with Taylor, I've been blessed to be able to like figure out a few things about how to help people and hopefully we can continue doing that. So it was very alarming for me just even though I knew it but to really see firsthand the amount of medical gas lighting that goes on.
to women in regards to hormones is pretty, pretty earth shattering. Yeah. No, it definitely is. I think it kind of gives you an insight. Like, I know you know that it's been going on, but like, with all the women that I've reached out to you, like in being a woman who spent years trying to figure out what to do about my hormones and years of being gaslit, by doctors, um, by the wrong doctors for hormone replacement therapy.
It really just brings it to more of an insight. Yeah. And it's, it kind of, in a way I like, It makes me glad that doctors are more open now to prescribing BHRT, but it still a high percentage of it not being done properly. Um, So, I mean, it's the same cases that you're getting or cases I hear all the time. And I think some of the cases you were telling me about, like I was so shocked by how behind some these delivery method systems were.
Injectable testosterone compounded is I would say the more advanced way of treating women with testosterone therapy. But some of the other compounds that you were telling me that women were on for, um, like progesterone, it was just like, I was kind of blown away that some doctors still prescribe it that way. Yeah, it's unfortunate. I think the interesting thing when you talk about injectable testosterone for women, that is kind of, uh, its cognitive dissonance a lot of times on the
prescribers part is if you prescribe a man testosterone cream, they say it is good because it raises DHT, which gives men obviously a boost. because it provides that alpha drive type behavior, kind of the masculinization that you want from testosterone. Interestingly for a lot of guys, for instance, that like have very weak jawlines, DHT supplementation will help improve and like make their jawline more masculine. And so what's interesting is that a doctor will say it's good to have the DHTs increase from cream as opposed to injections,
which is less. But then when you go to women, it's like all of a sudden that doesn't apply. And it does apply because cream does spike DHT higher and the majority of women are getting compounded cream, which is causing more side effects and also aromatizing less. Aromatization is good. Estrogen is protective. However, in the case of a man, a cream might be better because it means that he might not aromatize as much, especially if he's overweight.
The cream could be Better because It won't aromatize much. Whereas for a woman, they're getting higher DHT and less arometization out of the cream, which ends up in more side effects like acne and hair loss and the less benefits like vaginal lubrication, mood stability and everything. And then they get in the game of, okay, well now they've got testosterone cream, now I need estrogen cream or oral estrogen because estrogen isn't high enough. It's another thing for a doctor to prescribe. Yeah. That too.
Yeah, I don't know if it's a grand conspiracy around that. I think it is more of a lack of knowledge, but it does. It's like, okay, well now you've got your testosterone, now we've get your estrogen. Whereas like I know, estrogen is obviously a part of the conversation. However, it also one of those things that if you give a woman injectable testosterone most of them will do well just on the testosterone because they're going to aromatize enough estrogen because the injectable testosterone saturates the receptors more so than the cream, and so they're going to aromatize more to get more of a therapeutic benefit from estrogen than they would if they were taking the creme.
And so that's just my philosophy on it. Obviously, some people do better on the Creme. That's totally fine. Some women do do on better the Creme, I'm not saying that the injections are the only way. I just think it's interesting that, the cognitive distance between saying CREAM is better for men because of the DHT, yet 90% of women are getting prescribed CREME, And we don't take that into consideration with them. Even though the dose is different, it still applies pharmacokinetically that it's going to raise DHT higher than it would if you were injecting it at the proper dose. Yeah. I think it'd still just so mind blowing to me how many doctors are, in my opinion, overly prescribing estradiol in perimenopausal women and premenopause
women without testosterone. It's always progesterone. Estrogen is what we still see a lot of doctors doing and not doing testosterone and, and in most cases, I'm not saying all cases. There are some cases that some peri pre menoposal woman need estrogen. Very, there are cases of that majority of case studies. The woman does not need as your dial until they are post-menopausal. And that is something that.
It's, it's frustrating trying to explain that and, um, as I see the women also too, they'll blame progesterone for giving them a negative side effect when really it is not the pro gesterones. It's the estradiol, because they don't need the estrodial. They really need to switch that out for testosterone. Yeah. they'll complain about being bloated. There'll complaint about spotting.
Spotting, they will complain being agitated and you know, it's just crazy to see how much of that we still see. Long story short, there's a huge opportunity in the market to help address this. And honestly, my goal in helping do this is obviously to to helped move the provider market. I think if you look at incentives in a market, it's going to be pretty tough to change the you just go around and try like,
try to open your own clinic and start servicing people the way you want to. Whereas if you control the if, you basically educate the customer and then tell the customers what they should demand from the doctor. And then you also let the clinics know that like hey, we have hundreds of thousands of people that want testosterone done properly. The provider is much more likely, based on the incentives, they're like, hey, well, if I want to treat patients and they are demanding this and it's actually working better for them, that's what I'm going to do. And so that is kind of the hope with it is to kind like flip the market around and say like hey power to the people and allow them to dictate where everything
is going. rather than just going to your doctor and getting gaslit because they took a class and they think it should be done one way. And there's no one right way to do it, obviously, because everyone's going be chemically unique. Anything else you wanted to talk about? No, I think I do have like a tech question right now. Yeah. It's because it's streaming and higher quality that it lagging a little bit when we're looking at it. So that's why, and you can't change the stream quality, but hopefully in the recording, because its recording locally, it shouldn't lag.
Okay. And guys, let us know if the camera looks like it is laging. All right. One other thing, just in terms of a project that I'm working on, I've always thought it'd be a really cool idea. So if people want to know information about user experiences with peptides, typically you would have to go search on Reddit or something like that to look at a bunch of people that are reviewing. Let's say you wanted to use a peptide that's not as popular, maybe like VIP or Velon or Cortilax, one that is not popular.
and you're like, I don't know if I should buy this peptide or I could use this Peptide. I would love to hear what other people's ratings and experience are. Typically, the only way to do that is to be in some crazy discord or Facebook group that has thousands of people, that it has a bunch of trying to sell peptides in it, or to go on Reddit to which you don' know of half the people on there are bots, if half of the ppl on their are just people in their mom's basement or whatever, i'm sure there's good pple on reddit. i am not trying knock redit. What I'm saying is there's never been kind of like a central research hub to where we kind have validated human experiences for certain peptides,
almost like an Amazon review system for peptide themselves, not tied to any particular vendor, just for people to be able to review peptids. Like, hey, I used cartilax. It completely healed my hip osteoarthritis or shoulder or whatever it is. I rate cartillax five stars out of five and here's why. Similar to how you would review something on Amazon. And one project I'm working on right now that I think is going to be really cool, hopefully it's up and running very soon, is an independent website where people can independently review their experiences with peptides to start building a research place where they can give
their reviews of peptide in a way that's verified, that is unbiased, and that also is not like an affiliate link sinkhole that people are just trying to say buy this from here, buy that from there. Just a place people could actually go and read about other people's experiences. And then also give their experience and share. And the reason I want to do that is because we have all of this backlash of there's no human studies on peptides. Imagine if you were able to go to a place and there was 17,000 verified user reviews of someone using FOX04 DRI.
All of a sudden now it's like, wait a second. It's not a clinical study in the sense of like being a PubMed published article. When you have that many people sharing their experience of what's good, what bad and rating it and maybe it is like a 4.2 out of 5 stars. I think that'd be really cool. So that's one thing I've been working on. And obviously part of that is making sure that it's not tied to vendors who are trying to use it to promote their brands and stuff. So I think to be much more focused on the peptide itself. That's one thing I'm working on and hopefully will be up and running.
But I have people go to. And I think the benefit of all the amazing people that follow us is you guys care about stuff like that, and you care About sharing your information. Obviously, you can do it anonymously, but like sharing Your experience to help other people maybe do that. Which leads me to the first question of the day from Jake, which he says, Can you discuss your research on MK777? Not MK 677, but MK 777 dosing timing and cycling versus versus other security dogs.
Not much literature on this one. Do you think it's legit? So I'll let Taylor talk about that first. Yeah. So, um, it was funny. I sent an email out about this and did not expect to get so many replies about. Um, product. Okay. 7 7, 7. There is not. really any research I've been able to really find on it. It is a, I would say like a newer molecule is what I'm going to call it and what i have experienced has been honestly just experimental on myself and on Hunter.
So I mean the difference between MK77 and MK677 is that The biggest thing is that MK77, it's not going to raise cortisol levels or prolactin. And that is where you're not gonna get the increase in the appetite, you are not getting the water retention with it, and it is not cause insulin resistant, whereas an MK677 can cause those. So, I mean, there is just not that much.
So when you have this class, MK677 is what's known as a ghrelin agonist or a GHRP, growth hormone releasing peptide. On the side of equation of the GHRP, we have a few things. We have GH2, GHP6, and ipamerelin are the primary ones that people would use to get the therapeutic effect. on the other side, you growth hormones releasing hormones. You have testamerelin, CJC. and you have ceremorella, and those are the categorical growth hormone-releasing hormones that most people use and are most places sell.
What's interesting about MK77, so MK677 works really, really well to pulse the pituitary to raise, or excuse me, to be a ghrelin agonist to rise natural growth hormonal levels. That is going to translate into the benefits of growth hormones, better sleep, better skin, better hair, recovery, all those things. The issue with MK677 and really GHRP2 and GHRP6 is when you do this via the ghrelin agonism, it spikes your appetite out of control.
Very similar to how hexameron can do as well. A little bit. Yeah. Hexerone is a little different. It's very, very strong, but people build up a sensitivity to it very very fast. Can be used to help people with like cardiac arrhythmias, AFib, things of that nature. Absolutely can cause more water retention because it's so strong. Similar to like MK 677. It's different. So it kind of like sits out there on its own. I think it'd be useful in some cases. But when we talk about MK 677, the issue was you get these great results, but then you do it for four to six weeks and you're starving,
which in case is going to be good if you trying to put on weight, But you are starving. For most people, that's going be an issue because they cannot control their appetite. And then also too, it raises prolactin and cortisol. And so obviously you have high cortisol, that's going to cause some issues. That's gonna cause, you know, exacerbate the blood sugar issues and then prolacin. It can make your mood off. it can affect sex drives and those things when you're raising prolactic, uh, past a certain level. And so that's why MK 677 wasn't always the best. Come along MK 777. And I don't know necessarily like what the chemical makeup of this compound is.
I have seen third party testing showing this legitimate. So again, I'm not enough of a chemist to know, but I've used it. and it did really well. I would actually say it's almost identical to ipamerelin in terms of the response I get to it, which is pretty cool because the reason ipamerelin is the best GHRP thus far is that you can raise growth hormone via ghrelin agonism without causing an increase in prolactin cortisol and without spiking your appetite and typically without any blood sugar issues.
Well, inter MK777, And I feel like it does the exact same thing that Ipameralin does for me via an oral route, which is pretty cool because for people that don't want to inject or they just want try something different, it works really, really well. So what I noticed from MK77 for Me, 777 For Me is that, I slept better. I was fuller, meaning that it felt like I taking two to four I use of growth hormone in terms of like the aesthetic look that got from it, Which is cool. Like my abs looked more defined and harder.
Okay. Yeah, that's good. That's typically not like a growth hormone thing. No, it's not, but I noticed that. Yeah. I definitely noticed though, like my heart rate was lower. My HRV was up using it. Even relative to like, do I use a Growth hormone? It actually was a little bit better, which makes sense because it is doing, you know, raising endogenous Growth Hormone levels and thus IGF. But dosing wise, what I would do is I start with 10 milligrams a day, Monday through Friday. That's what i did. And then I'd take Saturday and Sunday off, and I take that right before bed.
With that, I noticed no blood sugar issues. nothing but really benefit for me. No water retention like I would even from- It's like it has less water attention with that than I do actually with growth hormone, which is probably why I'm saying I feel like my abs look harder to find. Yeah. So again, that is strictly anecdotal. There is no clinical literature that I've been able to on it. It probably is honestly just something that a chemist out there, you know, doing the Lord's work developed to improve MK 677 to get rid of the benefits.
I would say it's comparable to Ipamerelin for me, for what it does. And so I really like it for that reason. But again, it is one of those things like mileage may vary, so you may take it, and you might not get those results. But so far I've had nothing but great experiences with it. And I think it'd be even one of those things, even if you're using growth hormone, I still like, there's a benefit to maybe like doing Monday, Wednesday, Friday growth, hormone and then Tuesday, Thursday, MK 7 7, 7 to just kind of get the natural pulse as well. But that's my thoughts.
You know, it's like it up to you to decide that. But I like it. I mean, the verdict for me from what I've used up so far is good. Now, in terms of cycle length, I'd probably do it like four to eight weeks at a time just because we still don't know. And so maybe you would run into some insulin resistance issues in the long term. We don' really know yet, but so so good Here's a good question from Savannah banana. I've been taking tests, subcutaneously, but I'm not sure I am getting any tests from it.
Why Taylor takes hers intramuscular. Yeah. So the reason why you want to take it in your muscular is going to enter the bloodstream faster. And when you do it sub cue, it actually gets metabolized slower. Sometimes it won't even fully metabolize into the system. Well, it will. It just is going to be much lower curve. Where's the intramuscular going have, I think more direct therapeutic effect to get what you want out of it. I. Think a lot of people to like, think that like when they have to inject intermuscularly that they.
Have to use a, like a super long, big needle. Whereas in like really you can just use it 28, 28 gauge half inch. size needle. And you just like, for most women, um, you know, delts are like a really easy place to inject. That's where I always inject mine. Um, yeah. I honestly, I think that size, needle hurts less than a 31. Well, particularly if you were pushing an oil based solution through it,
right? I just didn't even mean like putting that sized needle like into the skin. Cause I feel like the 31 gauges, like at a little time, it's like uh, crick, whereas in like the tip on the 28 gauge isn't as like sharp. Do you think that women have more sensitivity in their abdominal muscles because there's much more machinery down there for childbirth than there is for men. And so that's why a lot of women like I feel like you get more bothered by a sub cue injections in the belly than I do.
Yeah. You think there's like maybe more nerves? Yeah, whereas like in your shoulder, it's comparable. And if you're pretty lean, It just goes right in. It's really like a shallow I am injection, but I have a video on Spotify. If you want to check it out, subcue versus intramuscular testosterone, probably beat, beat it to death more than it needed to be. But it was like 30 minutes explaining that if want check that out. Again, whatever floats your boat, subq does not necessarily mean it's bad, but I would, I advise everyone to try both and see what works for you. Some people like sub q better, some people, But I personally like I am better and I know a lot of people that like, so it really just whatever float your vote.
Next question. Is there any peptide comparable to SS 31? Chemically, not really. I would say a lesser known one is humanin, H-U-M-A-N-I- N. And that is, I'd say if there was anything that was close to it, it's probably closer to SS31 than MOTC is closer SS 31. Humanin is an endogenous peptide, declines as we age, whereas SS-31 is a synthetic, is not endogenously human body.
But I'll say human is probably the most similar, perhaps with a slight edge in terms of brain health that you would get out of it. And the dosing would be the exact same for Huminen as we would SS31. One milligram a day is where I would start five days on, two days off, eight week cycles. Yeah, Huminnen works really well for a lot of people. I'd say it's probably not as good therapeutically as SS 31, but still good nonetheless. This is a good question. It seems to be popping up more and more. Stacking Reda and Ters, it's great, but my appetite is dead.
How long should I use both? It's really up to you to where you want to get with your goals. I wouldn't say that there's any difference between stacking those together as there is using one individually. It's just where you need to get to. And I like to tell people like, use it to reach your goal weight, titrate down, maybe cycle off, and then use that from there at low doses to give all the other benefits like inflammation, suppression, better gut health, brain health. Pretty much everything that GLPs are miraculous for, but that would be my recommendation. I don't think there's any different parameters around that as there is using either in isolation.
How to handle hematocrit and cholesterol on testosterone therapy. You said not to donate blood. Why? And do more zone two cardio. Is there anything else that can maintain good blood levels? Thanks. First caveat to this question is most guys get their hematic at 50 and they think it's the end of the world. There are people that live in cities that have high elevation that run 57, 58 hematocrit and they're perfectly healthy and the reason is because there's less oxygen when you live at elevation. So first thing is like, first of all, don't get upset or think that something's wrong if your hematic rate is 51, 52. Mine is typically like 50, 51 and
I worry zero about that. Most doctors would not agree with that. That's totally okay for them to think that you also have to understand too, when we have a higher level testosterone, it's just naturally going to have that byproduct. And it doesn't mean it is a bad thing. Now you start getting into the sixties. Okay. At that point, It's like, maybe there's something wrong there. So the first thing is like most people don't actually have hematocrit issue. They think they do because it outside the normal range because the range has low testosterone. And in a lot of cases, thus low hematocrit. Not always, but anyway.
Now the next question is like, okay, well it's in the sixties, then maybe we could do something about it. To which the first thing is going to be to do cardio. Like most men don't do cardio every single day for at least 30 minutes. And if you're not doing cardio every day, for a least thirty minutes, and you are not walking, you aren't getting ten to fifteen thousand steps in, Yes, you may have issues with hematocrit on testosterone. And so that would be, the next thing is like, just like doing cardio is important for anyone that's not on Testosterone, it's even more important, for someone on testosteron to do zone two cardio.
The next piece of that is to not donate blood. Here is why. Yes. If your hematic crit is quote unquote high and you donate, blood it will go lower. Then you think the problem is solved. the issue there is that you start to become anemic. So if you don't eat blood, even if it is quarterly, that a lot of times will be enough to make a man anemic to which is iron and ferritin are now low. And you start to run into anemia issues because you're donating too much blood because your hematocrit is high when it's really not. So it is a very complex conversation to have because it goes against a lots of medical entrenched dogma.
But for me, even up until like the 54 to 55 range, I don't get concerned with hematocrit. And if I would, i would say, okay, well, how many hours a week are you doing cardio? And almost always that will resolve it. Then from there, it's like, Okay, let's look at some other things. What elevation do you live at? Is that causing any issues? And then from there, you know, You could get into peptides and stuff and, like, Vessagen is the blood vessel peptide, it can do it. In terms of cholesterol, most people will not have issues with cholesterol on testosterone if they're doing everything right.
And so again, if cholesterol becomes an issue for someone, we have access to GLPs, which typically improve cholesterol. I would use an SGLT2 like Jardians because that's going to have indirect effects on cholesterol, you could use something like a citrus bergamot to improve HDL levels. And typically, again if you're doing everything right, cholesterol is not going be an issues on testosterone therapy. But the same way that you would approach having healthy, quote unquote cholesterol management, for any other person, which would in my opinion not include statins,
you would do the same thing on testosterone. So it really comes down to the fundamentals and the foundation of it. Which one? Oh, gotcha. Forgot to put the questions on the screen. Kat says, I eat eight grams of saturated fat daily, but my cholesterol is through a four in total and 202 LEL and I'm in a weight loss phase. This is normal. What can I do? That's a little bit high. And most doctors say like, okay, that's really high, we need to get you on a statin, especially if you're not eating that much saturated.
Here's the thing with cholesterol. I am not an expert in cholesterol by any means whatsoever. Please do not take like anything I say about cholesterol as dictatorial or authoritative. But what I would do in that case is look at my hormones and say like, okay, where are my hormones at? And how is that affecting potentially my cholesterol? So is my testosterone in range or in a healthy range? Is my estradiol in healthy ranges? Because that can affect lipid levels as well. And so that would be my first thing. Then from there, we know Catherine, so I think that will be something like she's pretty fit and is always doing everything there.
What does like stress look like and everything because cortisol can effect blood sugar, which then can cholesterol. And so the first thing I would say is like GLPs tend to help with that and help the inflammation. There's these whole class of PCSK9 inhibitors to which I don't really know that much about but they seem to be better than statins and so maybe in the future that's we have more data about that being an option. But in the short term, I would say that I think that the best way to say it that's not going to, like, be, again, with my limited knowledge of cholesterol
is the cholesterol conversation. I Think we can all agree that cholesterol conversion is much less relevant when someone has healthy body fat levels and they have low inflammation or no inflammation in their body. And if you're controlling for body fat and you are controlling it for inflammation, I think the cholesterol becomes less important. I'm not saying it's not important, but I don't think it becomes more relevant than if someone is inflamed or overweight that then has high cholesterol. And also too, what are triglycerides like? What are some of the things that we look at for the inflammation to see from there?
So again, again I do not claim to be an expert by any means on cholesterol, that would be my recommendation. Then she also says, had to come off estradiol and was switched to an colmophene 12.5 weekly. You heard of this for female production. Hormone production, I have not. I would not do that. What doctor had that happen? Sure, women can use colomophane for fertility purposes, but in terms of getting on testosterone. One thing that I just don't understand is what is wrong with bioidentical testosterone?
especially for a female that is still menstruating and ovulating at the right dose, it can actually be beneficial for fertility purposes. And I don't know why they would have put her on estradiol without testosterone with her cholesterol. I mean, it could be, or it just be that that's like, you know, that you have no testosterone. Testosterone improves lipid panels if it's healthy. Not if you're doing like two grams a week of testosterone, obviously you might have some issues, but if your doing it, if have a healthy level of testosteron
in the body, its going to improve lipids panels. So no, I haven't heard of that. I would probably run away from that doctor if they were giving a woman in Clomaphene. Yes. That would be my opinion. Yeah. even that's menstruating and ovulating testosterone and progesterone. I don't see where there would be an issue unless the doctors are scared of their medical license. Jake says, as a healthcare provider practicing HRT, send me an email. If you're on my email list, just sign up for my e-mail list and you'll see my emails.
So that the best way is to send an e mail. Honeycomb in the house. Hope you guys are doing well. Much love. Shout out to you, guys. What are your thoughts on ATX 304? I love it. I loved that molecule so much. Like I, I don't know. When I actually had somebody ask this question in the group, whether it was like ATX, Sloop or Bam, like which one I would pick. And I will pick the ATx.
When I'm on that, I have really good cardio sessions. I feel super lean and very muscular defined when I am on it. It does not stress me out. Sometimes after being on sleep for an extended period of time, the mitochondria is spinning happening and I can get a burnout feeling. But I don't get the burnout with ATX. I think it's much more of a long-term solution than sleep or bam. I should view those as more like short- term interventions to achieve a certain goal.
The problem, what's not, I mean, it is not a problem with ATX. But the issue is for me to get any sort of therapeutic effect, typically I have to go to like a five to 700 milligram range of it to really see the results. And if you talk about a bottle that comes with 30, 100 milligram capsules, that's going to last you a week and it was like 300 bucks for a bottom of that. So is it worth 1200 bucks a month to have for most people? No, but I do like it. And the human studies that were used on it, they used 1000 milligrams a day and they had only positive health benefits.
So no adverse effects, no increase in resting heart rate, only benefit in cholesterol profile, Only benefit and reduction in inflammation benefit, and body composition. But you take 200 milligrams, 300 milligrams you're probably not even gonna feel anything at all. I think I forget sometimes how expensive that product is. When I talk about how much I love using it probably because I'm not the one ordering things in this house, like I do forget that it is expensive. Yeah, it just becomes cost prohibitive. So if you have obviously fixed resources, you're like, okay, well, do I want to spend that much on this? Yeah.
I think there are better things that you can get paying for your buck, but I like it. It's an AMPK activator, so it exists more on the kind of autophagy slash longevity side of things, much more than the muscle growth. or stimulation or anabolism side of things. The only thing I would say for people is like, in my experience, using it around a weight training session is almost equivalent to like taking metformin around the weight-training session. You will feel like you are weaker.
And so what I like to do is either use it before cardio or use in the afternoon, like if I train in a morning, use an afternoon because I don't want to take it in that four-hour anabolic window to which I'm focusing on muscle growth. I only use on my fasting days. Yeah. But I think it's great and I don't see any increase in heart rate or any sleep disturbances, even if you take it at night. And again, I like it as just one of those things like until the cost comes down, people aren't going to be able to take enough to really see the effect
of it. 73, been on HRT, peptides for inflammation, healing and 14 week mitochondria. protocol, oh, sorry, sent proven truly, ADSS 31 mod C, I'm having problems with hair loss and suggestions. The first thing I always gonna ask about hair-loss is are you using desiccated thyroid to support the thyroid? Because all those things, what they're gonna do, if you're losing weight, the body kinda goes in the starvation mode and then all of a sudden now you start losing hair because you ramping up your metabolism, you losing the weight which a lot of people need to do and will have long-term health benefits.
However, when you go into starvation mode, all of a sudden now it's going to potentially do that. So obviously the HRT is great, but I don't know if that HRTs includes desiccated thyroid or some sort of thyroid support. And almost always when I talk to people, that's the thing that is lagging. Because when ramp up metabolism, even when your just on testosterone, there's gonna be this negative feedback loop on the thyroid and it is gonna affect conversion of T4 to T3. And that's why I am a big fan of using desiccated thyroid. You could even try the thyroid bioregulators to see if that helps. But that would be my first suggestion around the hair loss is you're probably a little bit too much in starvation mode, which is causing the thyroid shutdown,
Do you think Reda is enough to combat insulin resistance from HGH use? Personally take four to six IUs. Yeah, so if you're getting into the four or six, I use, that's where you can potentially run into some higher blood sugar levels. I do think red up probably, it's gonna be dose dependent. And so maybe like 500 micrograms a week of red is gonna enough, but two to four milligrams a weak is probably gonna to be enough. Also too, and I would do this and don't even run that high of GH. Sometimes I'm doing like four Ius. Metformin plus an SGLT2 would pretty much eliminate any need for things wrong with your blood sugar there.
And so I would say RETA would be good, but if you don't want to take the dose super high of Reta, Jardient plus metformine, even if just 500 milligrams a day of met formin will be. I'm not using folistatin, so, I can't really talk or speak to that. Taylor does progesterone all month long suppress ovulation. I'm on 200 daily. No. Yeah. We've kind of been going back and forth with this, but Taylor has ovulated using 200 year cycle long.
And never had any issues. So if anything, I would think it would probably enhance it, right? Yes. Okay. It would. The only time that, okay, let me go back to that. Sorry. Um, the reason why some women would need to cycle it and only do it day 14 through 28 of their menstrual cycle is if your menstruial cycle, if you were doing it year, like every day and your menstrual cycles, days of actually bleeding come like shorten and you're cycle there.
The bleeding is so light that it's causing issues with that, that's when you would want to do the cycling and only do it day 14 through 28, only if it's negatively like affecting your menstrual bleeding and having you bleed less cycle. Vaginal estradiol and DHA are great impairment pause for dryness and uncomfortable intercourse. I agree. The only thing I would counter to that is that typically if you have testosterone, that's going to help a lot as well. And so I wouldn't say like, yes, if have a woman that has no testosterone and give her vaginal astrodial, it probably will help with dry.
Definitely will. But what I'm saying is to get to the therapeutic benefit of where you actually want to feel really good across the board, you would want testosterone to be part of that equation. So I don't disagree with that at all. But I am just saying don' leave out the testosterone. Yeah, especially period menopausal. Interesting comic relief question. Is it true taking super physiological doses of testosterone makes dudes gay, hilarious, or true?
Not in my experience. It's actually more gay men are willing to do testosterone therapy than straight men. Yeah. And not because of like that, I mean, honestly, what a lot of it is, is also from a physique. Same point, because I think, per capita, gay men have much healthier physiques than straight men do. If you just did a population level study, you would say, my experience, no, having taken testosterone as high as like 750 milligrams a week,
not say that it changed my sexual preference whatsoever. There are like these like Reddit forums of guys taking lots of trend and cause trend messes with your brain so much that they just get so horny. They just like will do anything. That's kind of like the saying with cocaine. Yeah. Kind of, like if you're on, you know, Well, I guess we'll find out but Speaking of like we can we specifically and explicitly condemn the use of any sort
of recreational drugs and I actually mean that but Yeah, I don't know if there's any data around that, but in my experience, no. I think if anything super, super physiological doses of testosterone, you get to a point where it's almost just like you're kind of lethargic a little bit because the nervous system is so overtaxed. Yeah. That makes sense. Obviously there is going to be a sweet spot with anything. What do you guys think of Dear Morphin? I've heard of people using it for pain, honestly I can't speak to it, so I would not be the best person to ask.
Yeah. It's like a peptide for pain. I think it's actually like, a veterinary peptides, if I'm not mistaken. Don't quote me on that, but, uh, best or by regulators for organs versus organ supplements for best healing. By regulators will probably be more beneficial, But I would say, why not both? Yeah, Shannon, what's up, dude? Good to see you here this morning. Yeah, honeycomb, you guys know where to find me, reach out.
There's one thing I'm working on is trying to like basically have like a platform that kind of becomes the like kind de facto like human research hub for peptides. Jim says, in all your travels, what's your favorite gym you've trained at? Oh, this one. Dragon's Lair in Las Vegas is pretty cool. Yeah. I would say dragons.
If you're, if you were a true meathead, dragon's lair in las Vegas, is like where all the bodybuilders in Vegas go to and film and stuff. It's pretty. Although I will say the gym here in Raleigh is, um, Optimus? Olympus. Actually, no, it's not like a travel destination. Olympas, they had old school gym equipment, like their machines. And it was just so, so it, was smooth. Yeah. I'd say that one.
Cause they have like all the machines from the eighties, but they're actually like in good work. Like they've been restored, which is kind of cool. Because like, a lot of those older machines, there's like movement patterns that you just don't have on a whole lot. Of newer machines I really liked. It was the gym. that we were at when we went to Andorra. At the hotel. For a hotel gym, that was probably like, what am I? For hotel gyms. It was one of my favorites. And they had a really good, they hit a plate loaded lab.
Pull down machine. Yeah. Yeah, I'd probably say the coolest was Dragon's Lair. Dragon Laire was definitely the coolest though. Like if I lived in Las Vegas, that would definitely work out there. Assuming it wasn't too crowded. Taylor does not have a Spotify. You should probably upload some of your videos to Spotify You know, everyone always talks about like, go to rumble, Go to Rumble, I don't think it's a bad idea to go RUMBLE, but how many people have a Spotify account versus a Rumbl account?
Way more people on Spotify, which is why I put my stuff on spotify. You can also listen to the audio or listen To the video, Which is pretty cool with Spotify. So I'm a bigger fan of going to Spotify than Rumble because I don't disagree that it would be bad to go to rumble, but like way more people have Spotify. Then they do rumple and a lot of when Joe Rogan like went exclusive with Spotify, which he's not anymore. There was a big migration of people that like got Spotify accounts and like started using it more for podcasting. So, I think for the podcast nature of it, Spotify is much better.
And that's where I will upload this when I am done. You can't live stream on Spotify which would kind of cool if you could live-stream, You can't, as of now. I want to improve memory and recall. P21, Cerebral Iosin, Dihexa. Do you believe in theoretical cancer risk with DiHEXA? I'm not a big believer that the DiHeXa at the doses, you know, 10 to 40 milligrams a day is really going to have any issues there. DiHexa, I think, would be a good start. p21. i would say like Di Hexa would intro, p 21 would intermediate, cerebral IOSin would advanced.
So they all work, they'll work well, just as a matter of like what you can source. Obviously dihexa oral supplementation, P20 and cerebral isin would be injection, but they're all, great. I would probably just like try all of them and see what she liked best. So I don't think there'd be any harm in like in isolation, trialing each of those and seeing what worked best Do you think that for somebody who is more, more so optimal and just trying to improve brain cognition and brain health.
Do you think that cerebral lyosin Isn't the, like the best option in the sense of like, for how much it's going to cost, how you're going, you have to use of it. Like versus like really for more optimal ranges, as you could really get that more so with P 21 or dihexa and like using cerebral isom mainly for like more. So like major cases of. Brain injuries and trauma to the brain.
I mean, that would be my philosophy around it. I think the problem is I've just talked to so many people that deal with like brain fog and stuff, or they get on hormones, but they their brain is like so clogged up still. And I I hope I don't offend anyone saying this, but I've just talked to a lot of people and they like want this like basically like they want like Adderall like, they wanted to be able to like sit at a desk and work for 15 hours a day and just be in the zone.
That is not normal human behavior. Meaning that like I create a lot of stuff. I work really hard. Yeah, I don't use that many nootropics because I Don't want to push my brain into that zone So there's this whole area that you could get into of doing like biohacking stuff That's good for your like that would be like turning your brain to a super supercomputer for me personally Like I really want ever go down that road I'm not saying like using peptides for a brain or bad what I am saying is At some point you got to pay the piper.
And if you're doing modafinil, if your doing like all these things to try to like basically just have Adderall or like feel like you are on Aderall. at some point it's going to like come back to bite you. I think cerebral Iosin should be reserved for either just like once a year. If you've had a lot of mental stress, if you had that, run a quick cycle of it once year and you'll be good. Or if have a stroke, TBI, concussions, something of that nature, or you're like early onset dementia or Alzheimer's, obviously then you would use cerebral isin.
I like P21 because it's a lighter version of it. You don't actually get a nootropic effect, but I think the same sort of like neurotransmitter modulation you would get out of P 21. Dihex is obviously going to be much more of kind of, like that noo-tro-pic effect. Which I, think is fine to take if you need it, I just would not lean on that all the time. But for someone like wants to improve memory and recall, i would say this, when you're hormonally optimized, your memory recall get a lot better. Yeah. And then when you have low inflammation, when your using a GLP, When you're exercising, training, doing all the things right,
your mental, Your memory and recall plays a big role in that and as basic as that sounds. I think there's still, I'm not saying this like this person's doing this or anything like that. I thing a lot of people, what I still see working with people is that a lotta people do not have their diet as dialed in as it could be. And I that's also a very missing. Yeah, it's just one of those things.
Lots of them. I also think with the cerebral isin, there's a big thing going around now of people getting cerebral protein, hydrolysate or something like that, which is like a lyophilized form of cerebralisin. And they typically come in 60 milligram vials. That's probably a lot better for someone that's just looking for the cognitive improvement aspect rather than the trauma healing, the stroke or brain injury type healing of like the, actually pre-mix cerebraliacin. And so you could use like 20 milligrams a day of the lyophilized cerebelliacine at night before bed.
I think have more of like the cognitive sharpness aspect without the overwhelming dose because typically like a five ml or a 5 ml dose of cerebiliacins like 1000 milligrams, 10 ml is like 2100 milligrams. So I don't think a lot of people really need that much. They just want like, a boost. or whatever. And so that would be my recommendation. I mean, there's no wrong or right answer, but that's how I kind of approach it.
Catherine says, started LDN, that I've been afraid of going above one milligram because I do get almost like a spike of energy and anxiety with it, I take it before bed, which I expect to increase the dose and how often. Typically your body will acclimate to it and so I would give it at least 30 days before I ever increase a dose by half a milligram if you're pretty sensitive to And so I would say like every 30 days, just acclimate to the half milligram increase. I find that three milligrams is my sweet spot. There is a contingent of people probably like 10 to 15% that it actually disrupts their sleep.
Whereas like for me, it makes my sleep so much better. And you can take it in the morning. So if that's the case, I will do it a morning and then you probably will just only have benefit from it there because the energy could be up. But in terms of like the anxiety, I would just say like very slowly titrate it. And if you have problems with it being too stimulatory, just take it in the morning. There's nothing wrong with taking it the What is the recommended dosing for glutathione? How much back and for how long? AMRPM, fasted.
It doesn't really matter if you're fast, I guess it's probably better. I do two to 400 milligrams every single week. So I don't cycle off of it because it is an antioxidant. And then I like making my concentration 100 milligrams per milliliter. Some bottles are 500 some bottles or 600 some models are 1000 some miles or 1500 milligram and so you got to use the peptide calculator for that. I do mine in the morning, though, but I typically like 100 milligrams per milliliters of concentration. And then I'll do that two to three times per week.
does Nandrolone actually heal injuries or just provide temporary relief? I mean, I think it does. It helps with like tissue repair. You know, one thought that I have around Nantrolon is that typically it's going to aromatize more than like a DHT derived compound. And I, think the extra estrogen, probably helps repair joints better. Whereas like a DHT derived compound, if used too high, it can actually dry you out, which could be good aesthetically, but then also too for your joints,
they kind of get creaky. But I think it does in whatever way it's doing. Is it as good as like BPC, TB 500, Cardilax, those things? I don't think so. Yeah, definitely could. My T3 is low at 1.8, but the NDT was triggering the MCAS. Any alternatives while dieting? Unfortunately not. You can try the thyroid bioregulators, But no, that's interesting. I've never heard of thyroid triggering MCAs.
Yeah. But I would also, you'd probably want to start low. So maybe you even have to do as low as like 15 milligrams a day and then work your way up until the body acclimates. Can you talk about SLU dosing time and results? Yeah. I mean, I'm not going to do a huge spiel because I've got so many videos about it, but I would say start at 250 micrograms per day, work your way up on the high end, out to 750 micro grams to one milligram. and then kind of sit there. I think the thing with SLU is you don't necessarily want to feel this overwhelming effect from it because if you're doing that,
eventually you are going to be robbing Peter to pay Paul and you will have this build up of reactive oxygen species that can be detrimental. So I like it, but I just like the lower doses. Having trialed both, having tried 400 milligrams a day versus 250 micrograms a days, I liked the low dose. That's just my personal preference and what I see better. I like the lower dosing. It's also important too, before using Sloop, is where are you at already with your mitochondria, because it's going to cause the mitochondrion to spin.
And if your my mitochondrial cells aren't healthy, you don't want to necessarily get that spinning effect on unhealthy mitochondrious cells. So I think running MOTC SS31 prior to using Slop is important to do beforehand. Yeah, that's a good point because SLU can actually amplify bad mitochondria. So if you have mitochondrion in a bad state, again, this is why I think you'd go back to using SS31 before any of these to heal and improve mitochondrial function.
Hey Suzanne. She says, I agree with larger needle hurts less. I use 29 for my test, intramuscular deltas and sides of upper legs. Strengthening my right side abdomen hurts more than my left abdomen with 31 needle for peptides. That's so funny. My left side hurts. Um, hurts me too. Well, she said her right. Okay. Yeah. Mine's the left. It's just with women, you probably have a lot, like I said, a little more machinery down there that's more nerves, more sensitive to belly shots. Estradiol is at 50. I'm on TRT.
Any solutions for this in addition to the Enchlomophen? Yeah, I mean, you could do like oral estrogen. Obviously, like if I wanted to raise estradiols, that's what I do. If I get estridiol sipunate and I inject half a milligram to two milligrams of estrdiol per week, That would be my recommendation. I would not use a cream of estradiol. You could use oral. I think the oral has like transient effects though, but my experience is the injections work the best.
And so I wouldn't inject one to two milligrams of Estradiola subunit per week and that definitely will get you where you want to go. SS 31 seemed to disappear because of the FDA approval. Do you think it will ever come back? SS31 is still, uh, there's no, you just gotta be, it's not for public consumption, but you've just got to know where to find it. So smart people will find any input on cerebral isin. Uh, hopefully you guys were listening. We kind of beat that horse a minute ago.
I've never used nine MEBC powder. It basically like is supposed to restore dopamine function. I think you'd probably use it at like 20 to 30 milligrams a day would probably be the starting doses from what I read. But yeah, I'd think it'd be good. it's just not something I ever had to do. And I haven't personally used it, so I don't really, like talking so much about things that I personally haven' used. Yeah, regarding cholesterol, this is what I brought up earlier. I'm pretty sure Repatha is a PCSK9. Don't quote me on that, but that's what was kind of talking about being a replacement for statins.
Will you guys cover a sleep stack, please, for waking up too early? I like a growth hormone peptide. Obviously I've got videos about SleepStack that you guys can look up. Growth hormone would be the first one. I think epitalon can be really good for resetting circadian rhythm. And just because we've been using that recently as of late for fertility purposes, I do notice that it may always sleep good, but it does seem to help I don't get up, like when I take epitalin, I didn't up at all during the night.
I usually might get it up once, sometimes go to the bathroom like an hour before I actually get. But like the last two weeks I haven't even got up to use the. Bathroom at night, which is nice. Yeah. All that epitelin. Um, Decept. That's another one. Sloop bioavailable orally. Just talked about that. I think I do fine with it. Orally, I don't know if people will love to fight over Sloope.
It's just like, yeah, you know, it is what it, is I, think, and I it's cool, but I know I dunno, mean it just use it in short cycles and think it can be good, But I dont think its like a hundred percent necessary to use. Yeah, this person earlier was asking about their thyroid function and hair falling out. You may need more than 60 milligrams, so I would try to go up to 90 and see if that would be helpful. Do you know anything about PMDD, any treatment alternatives or additions to an SSRI like Zoloft?
Yeah. Progesterone is going to be a, going play a huge role in the nervous system. Um, especially for women with, um, PMDD progesteron testosterone too, but definitely you're going notice a lot with the pro testosterone. And the other thing too is that like, depending, I mean, Again, as long as it's not messing with the woman's amount of shortening her cycle days from her bleeding amount, some women need higher amounts of progesterone.
Like some of them do fine at 100, someone would need up to 400. Or 700. Even 700, most cases at 700 can be most post-menopausal women. So it is always important. progesterone really treating more so symptom based and symptom relief. Yeah. What are the key blood markers or track on TRT such as free and total T L H F S H S A H B G and at what testing interval? I think you only need blood work probably once you're dialed in like once or twice a year.
If you go to life extension and look up their male elite panel, so lifeextension.com and I look at the male, elite blood panel. Those are all the markers I would track. So I'll just look that up. It's bovine desiccated thyroid, same as pig thyroid. Why does one need a prescription for the latter? So it's not the same thing. It is better than nothing, but bovine is different from pig thyroids. Pig thyroid is in the exact spectrum and ratio of the human thyroid which is why it is Right.
I mean, if you could only get bovine, I think it's fine, but I would prefer porcine over bovine and you need a prescription for it because it is pharmaceutically controlled and the people that run the world decided that you needed a prescriptions if want to get porine thyroid, which I don't necessarily... It's not the worst thing in the word because we do know that at least we're getting what we say we, whereas with some supplements, you know, like I there's that study like 80% of supplements on Amazon either didn't have the ingredient or it was not... The amount that it said it I'm not cycling since I stopped estradiol.
Yeah, I would inject estridiol sipping eight. And I think she meant her progesterone. I am not. Cycling like menstrual. Oh, okay. Now I get it wrong. Not cycling. Since I stocked estrdiol, Interesting because like I feel like estradiol will actually cause issues with your menstrual cycle if you're still having a menstruial cycle. Yeah. So maybe, okay. If you are not trying to go back to the progesterone, I would say if are you not cycling the Progesteron, only day 14-28 of the menstruation cycle then.
Yeah, and you could add in the, again, the injectable estradiol. Probably gonna have to source that underground because most doctors are like, injectible estridiol does not exist. Injectable estradiole does exist, these are not the droids you're looking for. you will get gaslit and told that injectable estradiol does not exist. Whereas right now I can go and look up on empowerpharmacy.com and see injectible estridiol in their catalog that it can be ordered. But I've literally had multiple people tell me their doctor tells them an injectble estrdiol doesn't exist, but it very clearly does.
And estrodiolcipinate exists and I would inject starting at probably one milligram. I even inject estrediolcipinate sometimes. The reason I do that is if you're a man, I think half a milligram to one milligram of esterilisipinate improves sex drive and improves lipid profile and it improves overall well-being, especially if your lower aromatizer like I am. Typically I just don't aromatize that much of my testosterone especially it's a lower dose like 200 milligrams. And I like throwing in some injectable estradiol.
I'm not doing that currently because I am taking HMG and HCG for fertility and I getting like extra estrogen out of taking those on top of my testosterone. But for guys that are not taking that, I think it would be one milligram of injectible estridiol per week can do wonders. And people are like, that's so counter to like what most people would think is even in the realm of something that you could do. but I support it. Yeah, Wendy says, definitely take testosterone, took tests before anything.
Yeah. Very good point. And then obviously the need for vaginal estradiol and DHEA can help, and then D HEA aromatizes as well. Talking about Catherine, that can be something that could help probably raise estridiol levels as. Well, we're to get. What about kiss pepton? Yeah good. Good. I don't think it would be therapeutic enough, but it wouldn't hurt. Legit desiccated thyroid from your doctor. If you have a good TRT doctor or HRT, doctor, and then telly rx.com T E L Y R X.
All the people that watch all the time are like, just get probably get so tired of us saying the sources that we say, Taylor, what is your sleep sack? How do you fix waking too early? I keep waking up after five hours. Um, so sleep, I'm going to tell all this sleep sacks that I've tried is dream catcher spray. um, from soma chems that has, that helps a lot. And then I would say Lodocytraxone growth hormone.
and I will say like right now we're using epitalon and that, has been getting me like in really deep sleep. But I being honest, um Hunter and, I have been seeing, a practitioner do color puncture therapy. And I will say like, since doing that, it has really helped improve my sleep doing the color puncture because it's also working on a lot of, I mean, we're all human. We all have our internal issues that we battle and it really helps me the most with dealing with, you know, anxiety, any kind of like blockages,
any type of like PTSD, and really helping my nervous system on top of that and progesterone does help as well too. So I think also I beneficial to just like kind of like dump out whatever is going on in here. So like journaling through before bed, like even if it's just writing down like all the random thoughts that are coming in your head, even they don't make sense, it doesn't have to make since. Like that's always beneficial.
Reading fiction before bad is really helpful for me personally as well too. But I would say those stacks have made the biggest And then throw in a gram of magnesium and that will help too. Yeah. I think that's just, we lose that when we talk about peptides for sleep and stuff. LDM improves my sleep. That's interesting. Yeah, I can do that. High dose B vitamin protocol in lowering calcium in my body cured me of MCAS.
Interesting though. I think VIP also seems to work really well for MCAs too. That essentially about the high dose vitamin. And I wonder if thiamine vitamin B1 has anything to do with that? That is like a very underrated supplement. Is Tessa better alone for visceral fat or is Tessipa better? Eh, I'd probably say TESSA. I think TESSIPA would be more of like what I would categorize as a muscle building. Yeah. Like you'll be really strong if you're taking Tessenip and you like put on some size. But I Think Tesser probably by itself probably would better for just visceral fat.
Both are fine. It could cause more water retention, getting them together as well, which can be discouraging. Just took some cerebroprotein, 60, I think they mean 60 milligrams, not ml a day for six days. Maybe you have super vivid dreams. Haven't had those in years. It's been weeks and still having amazing dreams, that's awesome. That's usually a good thing. Just started at Battallion, loving it. Do I need cycle or can I stay on? I'm 45, really liking the sleep. Thank you. What we're doing is we just did one milligram a day for 10 days in a row.
And you could do that like two to three times per year. I tend to see the effects linger after even taking that. So that's what I would do. There's like tons of schools of thought around that, but I am a fan of like one milligrams a day for like 30 to six days if you really needed to or you wanted to. But if we were going to do more extended, I would probably do lower doses, like 200 micrograms for a longer period of time. It's up to you. I'd play with it. At the very least, that we know of, there's not any sort of toxicity or anything from doing it, but I still wouldn't do it just based on the practice of
it coming from Russia. That tend to be where they cluster around from a dosing standpoint. Does half-life of peptides matter? Am I getting too complicated? If so, when should I pay attention to half life specs? It's kind of a hard question to answer. I do think half lives matter, but it's relative to what peptide because different peptids have different half lifes. And then it is also relative like what your goals are with it. So I would say they matter for sure, But it doesn't matter like, you know, like Does the BPC half-life matter or does it matter that you just take it?
You know, does the half life of Reddit TrueTide matter? It's like six week halflife. Should you do one shot a week or should you three shots a weak? That's the can of worms, right? Is one-shot-a-week better or is three-shots- a-week better? I think whatever you respond to is the best. And my experience split-dosing that is better the same way that split dosing testosterone, even though the half-life of testosterone is, testosterone siponates like seven to 10 days. But guess what? I feel better if I do it three or four times a week instead of one time a day or once every 10 day.
So it just depends, depends on the molecule, it depends the goals, you know, depending on your personal experience. I think it matters, but I wouldn't say like some peptides have a half life of 30 minutes. It doesn't mean it doesn' work longer than 30minutes because it's signaling and then that has a cascade effect over time. My family of six, wow, kids are 12, 12. 17, 19 is traveling to Europe next month. We aren't bringing PEPs, but what can we all take beforehand to keep us healthy? TA-1, Belon dosages, okay for the 12-year-olds. I mean, I think those are fine to take for 12 year olds. Diamond cell for one, if you guys are relatively healthy, probably diamond cell one by itself would be fine.
Just do one milligram. you know, probably every day leading up for like two to three weeks or so V long can be good too. You could do like one to two milligrams of that. Yeah. I would also bring that TA one with you. Um, just to use like, well, they said they're not bringing them. Oh, in my experience, if you put them in your check bag, going to Europe, I've never had a seasoned European traveler, even though I wouldn't like to be Europe the last two summers. So that's the only time.
That's true. So I'm just, I've been to Europe like 20 times. I been twice, but I never had issues. But, you know, if you don't want to take them just because of like having to refrigerate them, blah, it is kind of a pain in the butt. With the strips. You can get the strips too. Someone asked about the stripes, but I don't know if I can say where to go get them because they're like wholesale now.
But you can search for them. You just serve like peptide strips. Yeah. Might have an update on that soon. Kimberly, thoughts on using low dose rapamycin to clear senescent cells. I think it'd be good. Before I would use rapomycin, I'd probably use FOXO4, DRI, and just do like one milligram for 10 days in a row or like five days on, two days off for two weeks and do that. It'll be better at doing that than rapamysin would be. But I don't have a problem with rapamicin but I just think there's better things to get the same effect right now.
Sean, what's up, dude? Is it good to stack bioregulators together or use it one time? What would a few good stacks to use together be? And should you use two similar kinds at the same time or not? So in regards to stacking, yes, I think you can stack them. If you look up the bi oregulator cheat sheet. So if you just Google bi-regulator, cheat, you, can download that. I wrote an entire like 30 page guide on stacking by regulators. The reason is I can't, when you have 25 or so different products, it's hard for me to sit and have one question answer. This is the best stack. That sheet though is, or that document's like, 30 pages long and you can look it up and, you, can check it out and see like what are the,
best stacks. But like everyone has different goals. Some guys, the most important thing to them is fixing their prostate. And so there's a prostate health stack, but other people might be, you know, like fixing their immune system. And so there's a immune stack, but yes, there are good, it is a good stack. They are a stacking tools that you can use together. Here's your question, Leo, always coming through some good questions. Where did you get inspiration for naming your book, Testosterone of the God Molecule? Well, It came from the fact that for me, testosterone was something that when I didn't have of in my life, I would say addressing my severely deficient
testosterone massively improved my life from like a spiritual, emotional, psychological perspective because I felt like myself. And if you get into like spirituality, which would be like outside the scope of this call, but you'll get it to like just your own connection with God, whatever that is for you, whenever you would categorize that as, For me, it was, I felt most in connection with God when I was physically healthy because my testosterone was so low. Before that, was depressed, anxious.
I had existential angst of like, what am I doing on the planet? Like, why does my life even matter? Why am i here? And I struggled with that a lot. And i realized that once I got my Testosterone fixed, It gave me a sense of purpose to be understand that my life mattered. And I'm not saying testosterone will fix that for everyone, but for me, it's kind of like, you know, have to fix your health before you can actually help serve other people. For me that's what that did. So I would say like brought me into connection with the person that I was supposed to, because in my health at that time,
my total testosterone was anywhere around like 80 to 100 nanotubes per deciliter total, tons of concussions in my life. And for me, that was a massive improvement. So just bringing it together, I'm not here to tell anyone how to live their life spiritually or whatever. But I just thought it sounded cool too, when I was like writing, and I like, what can I call the book? And it was that. Probably for some people, they kind of get, not saying this is you, Leo, but some get triggered by the spiritual nature of things, because they're either atheist or they have their own spiritual beliefs.
And if you read the book, you realize that's not what the books about. It's just more about how that helped me. That one thing, solving that one problem in my life completely changed my live and how I viewed the world. I think in a lot of cases, testosterone is kind of like the red pill. Its the closest thing we have to like, the real life red Because once you take testosterone, the way you see the world is just completely different. You have a different kind of level of consciousness when you fix your testosterone levels.
And I'm not saying like doing super huge doses. I just saying of getting it fixed to where you're like in a healthy range. VIP stands for vasoactive intestinal peptide. That would be one, Catherine, based on just things we've talked about. With you on calls, I would definitely try like 100 micrograms of VIP to help with some of the MCAS stuff. I'm super new to everything. As a 40-year-old and focused on skin health, what should I start off doing, or in general, which should start taking if I,
if that just started a workout routine. um don't ask me that's for sure um so for skin health um i would say like as far as like like peptides go i GHK-CU is going to be really great for skin health. I think that growth hormone releasing peptides are going be great first skin healthy because they're going help with hydration.
When your skin stays hydrated, the less wrinkles, fine lines and wrinkles happen. And then another thing too is like topical, getting the right type of topicle peptide. for skin health, that makes a big difference. And you do have to be careful with topical peptides, serums and creams that I've recently have been learning about is that like if they're dose too high that can actually be damaging to the skin. Depending on how they are factured and how their chemically made, they could have peptide in them, but if it's not chemally structured properly,
It's actually you're not going to get any benefit from the peptides because if it's not chemically like structured properly, it actually will basically basically like Cancels it out. So even though like it might advertise that it has like NAD plus in it. If it's not properly, um, formulated that NED plus isn't going to really do anything. Um, so, and then, you know, getting just more on board, honestly, with the foundations of doing a good skincare regimen routine of like,
You know. Moisturizing, toning, washing, exfoliating a couple of times of reek, retinol makes a big difference on the skin health. Yeah. How to avoid freckles on Melanotan-1? I live in New York City. UV won't be anywhere above two to three until April. I think you'd take glutathione. That tends to help with skin lightening. And so you kind of will get this tanning from Melantan 1, but then also the, I kind it kind like mitigates some of that if people tend to like have freckels. It does. Yeah.
Um, and then, also topical glutothione, um, can be really beneficial to use as well too. Yeah. I think this was the second part of the question. No breakouts, just freckles when I tried it first time, but also Roman stacking with GHKU since it increases. Yeah, I What are your recommendations for rheumatoid arthritis? I mean, if I was just to throw out, you know, off the dome stack, PPC, TB 500, GHK, cartilax, PEG, MGF, and probably a low dose of a GLP like red F.
Yeah. I agree with all that. And that should, do that for eight to 12 weeks. It should at least get you going in the right direction and diet changing too. We'll make a big difference in that, um, I did have issues with that at one point in my life. So. Yeah. Experience with zits or breakouts in the bodies from taking melatonin. I don't know if that she means melotonin or melanotan, but I haven't. Could be either one, I've never, never heard that. Yeah, What if one has high mercury levels in the hair test, HTMA high-mercury levels should one detox or doesn't matter asking for a friend?
I don't really know that much about mercury poisoning. I would imagine that just priming the detox pathways like glutathione would be beneficial. doing stuff like sauna would be beneficial, but there's probably some other stuff too that is specific to mercury poisoning or like mercury overexposure that you would want to do to that. From a peptide standpoint, I would just think of like, how do I prime the detox pathways and make sure those are, you know, on point and assisting whatever I'm doing to get rid of it.
But anything you can to like sweat, get it out, it's going to be Obviously glutathione I think would help a lot. Probably an immune peptide just to help support the immune system. Thymus and also one SS 31 would probably be helpful as well because you're probably going to have impaired mitochondria function from mercury or any other sort of toxin overexposure. And those are all the questions. Wow. We usually have enough to keep us going for two hours unless people start popping some more questions in.
But all in all, good questions today. Definitely seem to cover a little bit of everything, which is always fun. So thank you guys for hanging out with this on a Saturday morning. It's always fine to get to do this. One more question. Okay, so are glow and glow stacks actually reducing GHKCU effectiveness? If you want the deepest of deep dives, I have a 42 minute video on my Spotify or iTunes about the glow in glow, and why they are okay.
And so I would I will check those out. But short answer is no, they aren't. And there's been multiple labs that have done degradation testing to show that they are not and so either the labs are lying, or other people are just saying stuff to get clicks and views because people respond to things that make them afraid more. So they respond. Things that empower them. And so that would be my suggestion is to take that video. I'm not saying that I have the definitive right answers. What do they own a company?
They have a higher amount. Well, let's play conspiracy theory devil's advocate to this. If you sell GHK, PPC, TB 500, KPV separately. Can you make more money on those individually than you would if they were in a blend? Yes, because if you sell those, individually, it makes more. I'm not saying that anybody would be motivated to do that, but you do make. Or if. You sell. Those individually.
Then if That being said, there are definitely peptides you cannot blend together. There is no blend of RETA and Ipamerala together, that'd be cool if there was, right? Or Reta and Tessa, like if you had those together in a blend. But yeah, I mean, Those ones have been shown to be stable. And again, I did the long video on it. So do you recommend reconstitution with phosphate buffer solution or backwater with GHK?
I always use GHk. I don't know. I've used backwater for my GHK. And so I would say, I don't know, enough to say there, but all right. Well, thank you guys for a lovely Saturday morning. I hope you have an amazing Superbowl Sunday weekend. Have some fun tomorrow night for the Super Bowl. Eat a little junk food. It'll be okay. Just take your peptides and you should be. Okay.
So thank guys so much. Make sure I get this uploaded to my Spotify. You can obviously check out Taylor's YouTube channel and everything. We'll go from there. I don't know if we'll be back next weekend, but we definitely should do at least one more in February of these. Um, so thank you guys. Just in closing, like without you, guys, we don' exist. So whatever form or fashion, you got to support us. Uh, just know that you are loved. You are appreciated and we would not be able to do this and have the privilege and honor of doing this without. And that's it. See everybody. Peace.