The Peptide Stack For Autoimmune Conditions | A Comprehensive Guide

0:10 Hey everybody. This is Hunter Williams. I hope you are doing amazing wherever you're at in the world. Today's video is going to be the peptide stack for autoimmune disease. So yes, this is probably one of the more requested videos I've gotten for a while now. And I really just wanted to make sure I had my ideas laid out properly for this. And also to have my own experience with this and then obviously coaching clients and everything. So I've got a bigger data set and sample size to work with now. I feel really confident in making this video about this stack.

0:40 What I'm going to be talking about today is seven different peptides, and some of them are not necessarily peptide, but seven things that you could use that I think anyone that is suffering from pretty much any general autoimmune disorder, which that's very all encompassing because there's a lot of different types of auto immune disease, But pretty much anyone that is suffering from that could use this peptide stack. And what I'm going to recommend is to do it for six months and see results in their life. I am not going say it's going heal anything. Obviously this is just an entertainment educational video.

1:11 So I m not telling you what to. This is not medical advice or anything like that. Check with your doctor before you do any of these things that I will be talking about. But basically, these are things that are tried and true to help with autoimmune disease. And I firmly believe if you put all these together, because I've used all of these agents myself, if we put these all together you are going to create a cascade of positive health benefits in the body that's going help if not heal auto immune disease, at least eradicate much of it. So what I'm going do today is present those different ones, talk about how they work within the bodies, then also talk how to work synergistically together

1:49 to achieve certain outcomes. And if you stick around to the end, what I'm going to do is present a dosage chart so you can screenshot that or whatever it is. It will show you exactly which one to take, when to it, and what dose to and how long you should do it for. So that's going be the outline of this video and hopefully you walk away with this. If you suffer from autoimmune disease or know someone that suffers from autoimmune disease. This can be a video that you share with them to help teach them about how powerful peptides can. So before I jump on and share my screen, just want to remind you guys, check out the peptide cheat sheet.

2:24 I believe almost all of these should be on the Peptide Cheat Sheet. If you need help with like how much water to put in the vial, how to withdraw out of the insulin syringe, Et cetera, et cetera. You can do that now. The dosage of the peptides I'm going to talk about will be different than the dosages that they are on the Peptide Cheat Sheet for. And that's because when I have those peptide on Pptide Sheat sheet, they offer a specific condition. So for instance, TB 500 will before a joint or tendon or soft tissue injury on a Ptide cheat sheet. In this case today, spoiler alert, we're going to be talking about TB 500 for autoimmune disease, so the doses are going be different.

3:00 So don't get caught up in the fact that the peptide cheat sheet might have a different dosage than I'm talking in this video. The peptides cheat sheets talks about the use case of those peptids in isolation. So I get a lot of comments on the videos that are like, well, the cheat sheet says this, but you mentioned a different dose. That's because I'm talking about different use cases. The same way, you know, would eat a difference amount of protein if you were trying to build muscle versus lose fat. You probably wouldn't change it that much, it would still be different. So you'd probably, carbohydrates would be a better example. you're going to eat more carbs when you want to build more muscle.

3:30 So you can't have like a standard dose recommend of carbs for everybody. The cheat sheet is the most generalized version of what would be safe for everyone to use. And then today we're gonna be talking about specific use cases for autoimmune disease. Don't freak out if those dosages are different. What I'm going do is share my screen and today, we are going get into the peptide stack for Autoimmune Disease. All right, so this is going to be the autoimmune peptide stack. So let's dive into it. Before we really talk about this, what is auto immune disease anyway?

4:02 So basically, I want to give you kind of a clear definition. Obviously, it's kind hard to define because there's, like I said so much, but auto-immune diseases occur when the immune system mistakenly attacks the body's own tissues. Instead of protecting the bodies from harmful invaders like bacteria and viruses, the system targets healthy cells, which leads to inflammation and tissue damage. Think of autoimmune disease So what it says like auto means self and immune is the immune system, and we have the Immune System attacking itself. So kind of think of the body turning on itself in this case and that's what causes a lot of chronic symptoms we had from autoimmune disease.

4:38 Common ones, the most common ones are rheumatoid arthritis, lupus, multiple sclerosis, type one diabetes, chronic fatigue syndrome, Crohn's, ulcerative colitis. All those would probably be lumped in with autoimmune disease. You could even throw in like Hashimoto's and some of those other ones. Um, you know, go ad infinitum in a lot of these. And I think a of them are kind of pointing to the same thing, which is the body is in that state where it's attacking itself. So, um, symptoms can vary widely, but the Most ones are going to be fatigue, pain, swelling, and organ dysfunction.

5:08 So a lot of times, people are gonna be very tired. They're going be in a lotta pain whether that's joint pain stomach pain. You know, migraines. There's gonna swelling in the body. A lot people get swelling like in their hands and their feet and overall organ dysfunctions. Different organs of the bodies could end up shutting down. We don't know the exact cause, although I could go into hours worth of speculation about everything in the environment and stuff that people do to our health today. But basically, it's believed in summary to be a result of genetic predisposition and environmental triggers.

5:41 I think it is going to much more on the side of environmental But basically the body's going to express to whatever the environment is signaling to do. And if you're an environment of unhealthy food, toxic relationships, the toxic environment, runaway inflammation, The body is going express that and a lot of times that's in the form of autoimmune disease. What I discovered in research is that 8% of the US population, I'd probably say it's higher, but this is conservatively. So around 26 million people are living with auto immune disease, Um, and that's again, people that are diagnosed. So it's probably much closer, I think to like 20% at this point.

6:14 Um. And fun fact, notably nearly 80% of these individuals are women, which obviously makes them more susceptible to these conditions compared to men. I. There's definitely an emotional component to that because women take on a lot. A lot of times in mothering roles. And if they're not in a mothering role, they are in masculine role which a lot of times is counter to what they best suited to do and that ends up expressing in disease state. So obviously autoimmune disease is very, very complex but generally speaking it's the body attacking itself and generally women are much more susceptible

6:48 to it than Man, so let's get into the agents now. So obviously I just made a video about metformin on my channel. It actually did really well and I didn't get a lot of hate for it, which seems to happen. Thanks to my amazing audience and all the people that watch me for that. Metformins, you're like, oh, I came for this for peptides. Why are you talking about Met formin? Hunter, stop talking met formins. We get it. Basically met forming is I think the frontline defense in any autoimmune disease. so we're going to go crazy with peptide in this video, but Metformin really should be the frontline defense against autoimmune disease.

7:21 And this is going to be why. So obviously metformine is a diabetic medication. However, it has anti-inflammatory properties and can modulate immune function. You can go check out the video on my channel, 100 reasons everyone should take met formin. I thought it was a pretty cool video. We got great feedback, but basically it benefits to help reduce systemic inflammation and oxidative stress, which are obviously the key contributors to auto immune disease pathology. And what I'm going to do with each of these agents, and don't worry about the dosing. Again, I am going mention that at the end of the video so you don' have to worry that.

7:51 But basically just supporting evidence. So the way I like to think about things is just keep them simple as possible. Let's do claim evidence conclusion. Metformin, anti-inflammatory, it's going help eradicate autoimmune disease because of all the things it does for the gut and inflammation in the body. and study in cell death and disease 2019 metformin ameliorates autoimmune disease, basically amiliorate means to improve SAT vocab word there for you, but met formin Ameliarates Autoimmune Disease by activating the AMPK autophagy pathway so by inducing autopsy.

8:26 Through the AMPK pathway, it's going to help with autoimmune disease. So basically the study demonstrated that metformin reduces inflammation and improves immune regulation by activating AMP K autophagy, showing its potential in improving auto-immune diseases. There's met formin, had to throw it in there. I know you're like, come on Hunter, stop with it. Okay, now to the peptides, LL37. so I love LB37, I've used it a lot myself. It's basically a human catholicidin antimicrobial peptide with immunomodulatory effects. So not a lot of people know about this and it's relatively cheap, which is kind of nice as well.

8:58 You know, you don't have to break the bank, but basically it enhances the body's defense mechanisms against infections, reduces inflammation, promotes wound healing, and can help through doing that manage autoimmune symptoms. So basically I like to think of this as the anti-microbial, anti fungal, antiviral peptide, antibacterial peptides. If you have auto immune disease because of one of those things, This is really going to knock it out. And I think it's a much better alternative. I know it is, but, uh, you know, mainstream medicine doesn't really know this yet to, um, antibiotics and things that are used to treat bacterial infections.

9:32 So, there was a study in 2005 journal of immunology. So basically, LL37, the only human member of the catholicin family of antimicrobial peptides, modulates dendritic cell differentiation and dandritics cell T cell polarization, which basically just means it enhances immune defense mechanisms and modulate the immune response, making it beneficial for managing autoimmune. So remember with auto immune disease, the body is attacking itself and LL37 kind of is like a balancer to the immune system. Meaning if the bodies is too far one way on side of the response of attacking yourself, it's going to help modulate that and bring it back into homeostasis.

10:07 And obviously if it is not doing enough, its going help bring back to improved function. Really, really cool with Ll37. The next one obviously is BPC-157, the Swiss army knife of peptides. So basically it's derived from a protective protein found in the stomach and we all have BTC- 157 in our stomach. And it promotes the healing of the gut lining, which is very, very crucial for autoimmune disease. It reduces inflammation, it supports tissue repair, and it is crucial, for some of these ones that are more related to the guts,

10:38 like Crohn's disease and ulcerative colitis. um study 2010 journal of physiology and pharmacology effects of bpc bbc 157 on wound healing uh basically found that btc promotes healing of the gut lining and reduces inflammation uh which will help it with um crohn's disease and other things like that so whether or not you have crohns disease i think a lot of inflammation from the autoimmune disease comes from The Gut and BPC 157, the injectable version to me has proved to be very,

11:08 very helpful. You could use the oral version and probably still derive some benefit, but I really think the Injectable Version is the way you need to go until we have technology that will suggest otherwise. So next one is TB 500. People typically associate this with joint repair and wound healing. So basically TB 500 is a synthetic version of thymus and beta 4, which is naturally occurring peptide in the body. It aids in reducing inflammation. it promotes wound healing and regenerates tissue, Which will help alleviate symptoms of autoimmune disease.

11:42 So I know for myself using TB500 has drastically reduced inflammation that I may have in my body, wherever that may be, whether that's pain or whether it's just overall inflammation in my body and brain, I definitely notice with BPC and TB 500 a cognitive benefit from using both of them together. But basically a study in the Journal of Investigative Dermatology found that thymus and beta-4 promotes dermal healing. And in doing so, it reduces inflammation and promotes tissue repair and regeneration, which helps alleviate symptoms of autoimmune disease.

12:18 So again, another one you probably don't associate it with auto immune disease, but when paired with BPC 157, I think it does, you know, miracles for people, especially if they have forms of arthritis or something like that manifest and a lot of pain and swelling in the body. Next one is going to be thymus and alpha one. So again, this is probably more of the one that people would typically associate with helping with the immune system. A lot of people use this to help with their immune to some, whether they want to boost their system or even if they are suffering from a cold or flu or

12:53 something like that, thimus alpha 1 is very powerful in helping what those But basically it enhances the immune system by stimulating the production and differentiation of T cells. So it improves our immune response, reduces chronic inflammation, helps restore immune balance. Again, immune balanced. We don't want it too far, you know, in one direction or the other, all of which are going to be beneficial to autoimmune conditions. Um, thymus and alpha one, basically again, it's helping modulate the immune system so that we have a healthy immune response.

13:24 And, uh, in the case of autoimmune disease to prevent the body from attacking itself and causing all of this inflammation. Um. So basically there was a study in expert opinion on biological therapy, 2014. Uh, they found that thimus alpha, one enhances immune function. reduces chronic inflammation and restores immune system balance, kind of like we discussed. So all of these things are going to help contribute to healing of autoimmune. Now, SS 31. So this is, I think probably going to become the next BPC 157 that people use because really just scratching the surface of how powerful this

14:03 peptide is. And I've used it a lot of myself. I'm used to a of my clients and I am still amazed at some of the stuff that the people report back on what it is helped with. Uh, uh, think the more optimized you are, probably the less benefit you notice from it. However, would argue that I, you know, in terms of optimization stuff with what I do up there with the best of them, And SS 31, I still notice benefit, especially as it relates to my digestion. But here's what it does. So basically it's a mitochondrial targeting peptide that reduces oxidative distress and prevents or protects mitochondria function.

14:36 In doing so, it enhances cellular energy production, reduces inflammation, protects against cellular damage and in doing so is going to enhance the autoimmune response that people have. So there was a study in free radical biology and medicine 2011 and found that mitochondrial targeted peptide SS 31 attenuates oxidative stress and inflammation. Again, let's go back to where does auto immune disease come from. Oxidative, stress, inflammation in the body. Basically by reducing oxidator stress in inflammation, while protecting mitochondrial function, it's going to be beneficial for managing and I would say

15:11 eliminating autoimmune disease. So again, a lot of the problem with auto immune disease is energy production within the body. If you notice, auto-immune diseases, you have chronic fatigue, fibromyalgia, multiple sclerosis. A lot these people, they're almost bedridden and SS31 is going kind of jumpstart the mitochondria. And help with that. Now, I would say if everyone could get a red light bed and a true, you know, near infrared light spectrum, which often costs 60 to $70,000 to have in your house.

15:43 That is going to be what is the best for your mitochondria. However, we can almost get, not all, but a lot of the benefit from that redlight therapy through SS 31. So SS 31 is very new, but it's very powerful. And I would recommend it for everyone that's suffering from autoimmune disease, especially from an energy response. Typically someone has auto immune disease. They're not jumping around and bursting at the seams with energy. A lot of times, you know, they're in bed and they have brain fog and everything. So. The last one is going to be Terzapatite.

16:14 Wait a second, Hunter, Terzaapatide is a fat loss peptide. I use it for fat-loss, right? Well, yes, but I think Terzerapatde and the GLP-1 category of peptides are going be the next and most powerful anti-aging medicine that we have on the planet. because of everything they do for the body, especially as we're in this phase where human health is just going down the toilet abysmally. I mean, just go out and look in public now. These are going to be, I think you could make the case that everyone should be on these medications going into the next 30 years,

16:50 after the age of 30. So Trisapatite is a dual GLP-1 and GIP receptor agonist that modulates metabolic pathways. It helps regulate immune response, reduces inflammation, and improves metabolic health, supporting overall management of autoimmune disease. What a lot of people fail to realize is the importance of the metabolic response as it relates to auto immune disease, so a autoimmune disease is really poor insulin sensitivity and poor insuline signaling in the body that ends up manifesting an auto immune disease.

17:23 So obviously there's a lot of studies about trisapatite 2021 New England Journal of Medicine. Trisapetite once weekly for the treatment of obesity improves insulin, sensitivity, and metabolic health, which can help reduce inflammation. and again, manage autoimmune conditions. So I think whatever the treatment course is for auto immune, a lot of people leave out the insulin pathway. And I, think, you know, when we look at metformin plasters appetite, which I'm going to talk about in a second, those two together are arguably like one of the best things you can do. Now let's look how these work together.

17:54 It's great. We take all of them, but why do they work synergistically? So can we get like a one plus one equals 10 effect out of this instead of one, plus, one equal two. Let's, look, at inflammation. If we're attacking the pathways of autoimmune disease, what are these gonna do specifically to address those? So we have inflammation reduction. Obviously, if we can get the inflammation under control, that's going to assist in helping with auto immune disease. So the first thing we had is metformin, then we LL37, BPC-157, TB500, and SS31, basically all attack this inflammation pathway.

18:28 They work collectively to reduce inflammation at systemic and local levels, depending on if you have organ dysfunction. And by lowering the inflammation, these peptides help mitigate the autoimmune response and alleviate symptoms. Then we have immune modulation. So thymus and alpha-1 and LL-37 enhance immune system regulation, like I talked about, preventing it from attacking the body's own tissues. Again, that's really important because a lot of times in the case of auto-immune disease, the bodies attacking itself and we want to bring that immune back into balance and homeostasis. This immune modulation helps restore balance, reduces the severity of audioimmune attacks, auto immune disease.

19:04 Next is tissue repair and regeneration. So a lot of times we have damaged tissues around the body and BPC, TB 500 and SS 31 all promote healing and regeneration of damaged issues, which is crucial for recovering from autoimmune. A lot times, we had to go through this recovery phase because of how poor a state of health the bodies in. These peptides support the repair of affected organs and tissues, improving overall function and health. And then lastly, like I talked about, we need the metal box support and insulin signaling. So basically metformin enters appetite. Not only do they work to reduce systemic inflammation, but they also enhance insulin signalling.

19:39 Improved insulin sensitivity can reduce the risk of autoimmune flare ups as insulin resistance is a known contributor to the development And exacerbation of autoimmune conditions again think insulin resistance when we think auto immune disease that's almost all of it if not, you know, a good chunk of automated disease comes from this insulin signaling problem so by regulating blood sugar levels and enhancing our metabolic health. These peptides can help manage one of the major underlying causes of autoimmune disease. So where does that lead us next?

20:11 Well, I would be remiss if I left out diet and fasting from this presentation. I firmly believe again, to go back to the idea of environment that our diet, and the foods we eat cause a lot of disease, foods can be medicine or they can poison. And These are kind of my rules. I think, you have carnivore, keto, all these different elimination diets, which are good in certain use case scenarios. They're hard to sustain. When I look at my life, I have condensed down my eating to pretty easy six rules to follow.

20:47 If you follow these, Even if you are eating more calories than you think you should, or whatever your caloric burn is, I think it's much more important to follow these rules. If you follow the rules, it is really hard to overeat, and it also makes decision a lot easier. A lot of times, when you're working with people, they're like, can I have this? Can I? And these are just the rules. So it's kind of like if they don't break these rules, then it is fine. The first one is going to be no gluten.

21:18 Now, I think a lot of autoimmune disease is caused by gluten, but really, is it gluten or is the glyphosate that is on wheat? So, a think of times we associate gluten with the auto immune disease or, you know, uh, celiac disease or anything like that when I really think it's more the glyphosate, which is the roundup that is sprayed on wheat right before it was harvested that we're just mainlining. Um, so, uh. Gluten, I think if you're eating like organic, very, clean wheat. I've noticed this myself.

21:48 That doesn't cause inflammation at me, but if I eat like a wonder bread, you know, that will destroy my stomach. So is it the gluten or is that the fact that it is covered in round up? I Uh, but again, just for ease of use, I stay away from gluten unless it's, you know, like a cheat meal, um, or something like that. I think a lot of what it does to the brain just kind of makes the brand crazy too, cause it hits opioid receptors. So rule number one, no gluten. Avoid all gluten containing foods as it can trigger inflammation and exacerbate autoimmune symptoms. The next one is no seed oil. So seed oils such as canola, soybean, and corn oil are high in omega-6 fatty acids for a rule of thumb, which can promote inflammation.

22:25 Just stick to avocado oil, olive oil coconut oil and grass-fed butter. No added sugar. So added sugars obviously cause inflammation and can disrupt immune function and exacerbate autoimmune disease. No add sugar, so fruits would be fine. In that case, all fruits are not created equal. I would stick to more berries and ones with less sugar content, but still nonetheless, we don't want to have any added Next thing is no dairy.

22:56 I know this will break some people's heart. But I'm not going to get into the raw milk debate because I don't know enough about that. For the most part, you just should take dairy out of your diet. We're not meant to digest it. Some people do fine with it and that's okay. Good for them. Especially in the case of autoimmune, get rid of it, and finally, no alcohol. It blows my mind how many people suffer from auto-immune disease, yet they still consume alcohol, even if it's just casually. toxic to the body. So obviously it's going to increase inflammation. If you follow those five rules, and then the last one is going be to do a 24 hour fast, two to three times per week.

23:30 I mean, you're pretty much good to go. Obviously you can get into the weeds with that stuff, but if you followed these six rules with diet. No gluten, no seed oils, No sugar,No dairy,no alcohol and no eating for 24 hours, three times a week. You're going to be pretty much good. So that's about as simple as I can condense it down to. Obviously you can go off, you know, the deep end with diet and stuff. Um, which is going to lead me to my last slide. So this is probably going be the one like you want to screenshot or just save this.

24:01 I'm going leave this up and kind of walk through everything. Um but basically this would be. The schedule. Metformin is gonna be 500 milligrams AM and PM every day. Now I take a thousand milligrams, AM, and P.M. every. But if you're just starting out, I'd start with that and then you can titrate up. And there's no real benefit in going, you know, higher than a AM and PM, um, LL 37 is going to be a 100 micrograms every single morning. Uh, BPC is gonna be 250 micro grams every morning, uh, TB 500 is can be two 50 micro-gram every day.

24:31 Thymus and Alpha 1 is could be one milligram at night every SS-31 is going to be 500 micrograms every single morning. And then trisapatite is gonna be 2.5 milligrams, and that's only going be once per week fasted. So if I'm looking at injections, because everyone wants to know this, obviously, LL-37 is one injection. BPC and TB-500 can be mixed together, so that is two injections. And then SS31 you want to do as a separate injection as well. So most days you would have three different subcutaneous injections in the morning and then one at night.

25:04 And the first appetite is just once per week. You're only doing that once a week and the metformin, obviously that's an oral capsule or tablet that you swallow. What I would recommend for this, if you are suffering from autoimmune disease, now obviously the general rule of thumb is with peptides you wanna do eight weeks on and eight week off. Well, I would say for someone that's suffering from autoimmune disease and you really want to help cure that, you would be fine using all of these for six months consecutively. Now, yes, are you maybe going to have to increase the dose? Are you going have cellular attenuation from these?

25:36 Of course, but I'd much rather address the auto immune disease through using these and then take a break after six month and see where you're at. So I know that goes against the conventional rule that eight weeks on the way eight, weeks off. But again, it goes back to specific use case scenarios. And I think in the context of one of these autoimmune diseases that is hampering the body and hamper your life, you would want to use these and then kind of go from there. So again I realized that you're probably not going to feel the effects, by like month five or six, as you wouldn't the first two months of using it in

26:06 that first day weeks, but you can kind to go for there so that would be my general recommendation. Obviously use medical supervision. Listen to your doctor. This is just educational and no one should ever do this. What I'm saying, right? So that is it for these slides. And that. Is the autoimmune disease, peptide stacks. So hopefully that was helpful. I know it was a little bit longer video, but I really want to lay this out and step by step fashion to just show you kind of the science. or the theory or thought process behind all these and then how you can actually practically implement it.

26:36 So again, autoimmune disease, it varies widely. It's kind of all over the place. But it can be healed. And I think if there's one thing that you could definitely change your life relative to like other diseases out there is auto immune disease and peptides can definitely be like a game changer. For that, I've seen in my own life and not that I ever had like any serious autoimmune conditions, but definitely like family, loved ones and clients that have coached. I have seen it be a huge benefit. So hopefully that was helpful to you guys. If I left anything out, definitely drop a comment below and let me know.

27:08 that just to have the feedback from you guys. But thank you, guys, so much. I mean, the channel is growing amazingly. If this is your first time here, welcome. You know, like, comment, subscribe, all that stuff definitely helps. And obviously, too, check out the Peptide Cheat Sheet. It will sign you up for my email list. Hopefully, I think most of the people on my e-mail list find it to be very informative and very helpful because a lot of times it's written summaries of stuff like this I'm talking about in the video. So thanks again so, much guys much love out there and I will talk to you in