42 Reasons to Never Block Estrogen or Use an Aromatase Inhibitor
Most men on testosterone therapy get prescribed an aromatase inhibitor within their first few months. Three to six months later, they feel worse than before they started. This video breaks down why that happens, and why blocking estrogen is one of the worst things a man on therapeutic testosterone can do.
Quick note before we get into it. This is not a bodybuilding discussion. I'm talking about men on therapeutic doses of testosterone, not guys running a gram of androgens a week. Different conversation.
Why Doctors Push Estrogen Blockers in the First Place
In 2021, around 840,000 men in the US were on testosterone therapy. My estimate is that 20 to 30% of them were prescribed an aromatase inhibitor. That's somewhere between 300,000 and 500,000 men being told to crash their estrogen.
Why does this happen? A few reasons.
Doctors still think of estrogen as a "female hormone" that should be minimized in men. They overemphasize testosterone numbers without considering balance. They misinterpret symptoms like gyno and low libido as estrogen problems when something else is usually driving them. And a lot of old-school bodybuilding myths have leached into mainstream medicine.
How an Aromatase Inhibitor Actually Works
An AI blocks the aromatase enzyme. That enzyme converts testosterone into estradiol. Block the enzyme, and less testosterone becomes estrogen. Total estrogen drops. Testosterone may rise slightly.
That's the school of thought. Now let's talk about why it's wrong.
High Estrogen or Insulin Resistance?
Here's where things get fuzzy. A guy at 25-30% body fat starts testosterone therapy. He develops gyno, fatigue, mood swings, water retention, low libido, abdominal weight gain. His doctor says estrogen is high. He gets an AI.
But those symptoms aren't from high estrogen. They're from insulin resistance.
Fat tissue contains aromatase. The more body fat you have, the more aromatase activity you have, the more testosterone gets converted to estrogen locally. A study in Metabolism found a clear correlation between insulin resistance and increased aromatase activity in adipose tissue.
Insulin resistance also causes:
- Abdominal fat storage (Diabetes Care, 2011)
- Chronic fatigue from poor glucose uptake (JCEM, 2014)
- Erectile dysfunction and lower testosterone (Andrology, 2015)
- Mood swings from neurotransmitter imbalance (Journal of Diabetes Research, 2013)
- Water retention through kidney sodium handling (Nephrology Dialysis Transplantation, 2012)
Every single symptom blamed on "high estrogen" maps cleaner onto insulin resistance.
If you give a lean guy at 9% body fat 200mg of testosterone a week, very little converts to estrogen. Give that same dose to a guy at 28% body fat and a huge chunk converts. The fix isn't blocking the enzyme. The fix is dropping body fat and improving insulin sensitivity.
The 42 Reasons
Here's why estrogen matters for men. I'll move through these quickly.
- Cardiovascular health. Estrogen improves endothelial function in men with cardiovascular disease (2010).
- Bone density. Estrogen is crucial for maintaining bone density in men (Journal of Bone and Mineral Research, 2008). This is why guys on AIs end up with joint problems and start using deca to fix them. Deca just raises estrogen back to where it should have been.
- Cognitive function. Higher estrogen levels associate with better cognition in elderly men (Journal of Alzheimer's Disease, 2015).
- Mood stability. Estrogen plays a role in mood regulation and may reduce depression in men (Psychoneuroendocrinology, 2014).
- Skin health. Estrogen improves skin elasticity and hydration. Personally, I get more acne when my estrogen is crashed, not when it's optimized.
- Joint health. Estrogen reduces joint inflammation in men (Arthritis Research and Therapy, 2011).
- Liver function. Estrogen supports liver function and detoxification (Hepatology, 2013).
- Cholesterol. Estrogen raises HDL and lowers LDL in men (Circulation, 2010).
- Sexual function. Estrogen is crucial, not just beneficial, for libido and sexual function (JCEM, 2006).
- Immune support. Estrogen supports immune function (Nature Reviews Immunology, 2013).
- Muscle mass. Estrogen helps maintain muscle mass and strength in men (Journal of Endocrinology, 2011). When my estrogen is dialed in, my muscles feel fuller and my strength is better.
- Fat distribution. Estrogen supports healthier body composition (JCEM, 2009). If you think crashing estrogen helps fat loss, you've got it backwards.
- Inflammation reduction. Estrogen has anti-inflammatory properties (American Journal of Physiology, 2012).
- Energy levels. Estrogen helps maintain energy and reduce fatigue (JCEM, 2010).
- Hair health. Estrogen supports healthy hair growth. I'd bet most men who blame hair loss on testosterone are actually on an AI plus a DHT blocker.
- Sleep quality. Estrogen improves sleep and reduces insomnia in men (2011).
- Digestive health. Estrogen supports gut health (Gastroenterology, 2014).
- Blood sugar regulation. Estrogen helps regulate blood sugar and insulin sensitivity (2013).
- Metabolic function. Estrogen plays a role in metabolic function and weight management (Diabetes, 2012).
- Pain tolerance. Estrogen actually increases pain tolerance (Journal of Pain, 2011). Crash it and you become more of a baby, not less.
- Reproductive health. Estrogen is essential for fertility in men (Andrology, 2013).
- Thyroid function. Estrogen supports thyroid function and hormonal balance (JCEM, 2010). Crash estrogen and your thyroid suffers, which cascades through every hormone in your body.
- Heart rate variability. Estrogen improves HRV, a key cardiovascular marker (American Journal of Physiology, 2014).
- Mental health. Estrogen reduces the risk of severe mental health disorders in men (2015).
- Growth hormone production. Estrogen stimulates GH production, which matters for tissue repair and muscle growth (2009).
- Vascular health. Estrogen supports blood vessel health and circulation (2011). Critical for longevity.
- Hydration. Estrogen helps maintain proper hydration (JCEM, 2013).
- Better partner dynamics. Maintaining estrogen levels reduces relationship friction, especially around your partner's cycle (Journal of Family Practice, 2014). My relationship is genuinely better when my estrogen isn't crashed.
- Bladder function. Estrogen reduces urinary incontinence risk in men (Urology, 2012).
- Vision health. Estrogen protects against age-related vision problems (Journal of Ophthalmology, 2011).
- Prostate health. Estrogen plays a role in prostate health (Journal of Urology, 2013).
- Longevity. Balanced estrogen associates with longer lifespan and better aging in men (2015).
- Cellular repair. Estrogen aids cellular repair and regeneration (2012).
- Emotional regulation. Estrogen helps regulate emotion and reduce stress (2013).
- Muscle cramp prevention. Estrogen helps prevent cramps and spasms (2010).
- Nerve function. Estrogen supports healthy nerve function and reduces neuropathic pain (2011).
- Hormone balance. Estrogen is essential for overall hormonal homeostasis (2013).
- Erectile function. Proper estrogen prevents ED (Andrology, 2014). Any man who has crashed his estrogen knows the difference in erection quality.
- Alzheimer's protection. Estrogen has neuroprotective effects that may reduce Alzheimer's risk (Journal of Neurochemistry, 2012).
- Workout recovery. Estrogen speeds recovery by reducing inflammation and muscle damage (Journal of Applied Physiology, 2013).
- Libido. Balanced estrogen contributes to healthy libido and sexual performance (2009).
- Quality of life. Add all of the above together. Crashing estrogen has cataclysmic consequences for how you feel, perform, and live.
The Reference Range Problem
Lab reference ranges for estrogen in men are built on populations of men with low testosterone. So the "normal" range is low.
If your total testosterone is 300, maybe estrogen at 10-15 is fine. If you're on testosterone therapy and your total is 1200-1500, you don't want estrogen at 15. You probably want it closer to 50-60-70 to match the level of testosterone in your body.
Estrogen confers to the level of testosterone. That's the key principle. Higher T means you need higher E to match it.
My Take
If your doctor prescribes testosterone and routinely puts patients on an aromatase inhibitor, find a different doctor. Run.
The symptoms men blame on "high estrogen" are almost always insulin resistance showing up because testosterone therapy raised the curtain on metabolic problems they already had. The fix is body fat, training, food, and sleep. Not blocking the most cardioprotective, neuroprotective, joint-protective hormone in your body.
If you're on testosterone and using an AI, this is your sign to talk to a better provider. If you're considering testosterone, ask the prescriber about their AI philosophy before you start. And if you know someone making this mistake, send this to them.
Hormones first, peptides second. Always.
Full transcript click any paragraph to jump video
Hey everybody, this is Hunter Williams. I hope you were doing amazing wherever you're at in the world. Today's video is going to be 42 reasons you should never block estrogen. So this one probably also will be a little polarizing, but my intent with this video, is to basically explain why men, especially men who are on therapeutic testosterone, should never block estrogen. So before, I just want to kind of get in front of the people that may be watching this video. This is not in the context of bodybuilding. As we're going to see in today's video, once I pull up my screen, go through some of those notes is that a lot of old school body building myths about
suppressing estrogen have leached into the mainstream medical establishment as it relates to testosterone therapy. And so we're going to break all that down in this video, but I want to be very clear. This video is not for bodybuilders that are blasting super physiological doses of testosterone, and they're also using aromatase inhibitors. So this is going reasons you should not block estrogen, especially in the case of therapeutic testosterone use. So unfortunately, we live in a world today where most men are deficient in testosterone. And so if a man can even get to the point where he understands he needs a supplement with testosterone therapy, More often than not,
he is getting quacked by a lot of doctors and being put on an estrogen blocker and aromatase inhibitor in the presence of the testosterone, and typically within three to six months he's going to feel worse than he did to begin with. So what I want to do in this video is just make the case of why men should never block their estrogen. You know, again, the bodybuilding discussion is separate from this. I could also make that argument that bodybuilders should not ever block the estrogen, but again that's outside the case of what we're talking about today. So I just want to make sure that it's clear, because if you're a bodybuilder watching this video, hopefully you can take something and learn from it,
but I'm not talking out the cases of, you know, a gram of androgens per week, the, case for blocking estrogen there. I don't think it is right to use rheumatase inhibitors ever. But I think that is a separate discussion that we are going to talk about the day, which is just men on therapeutic testosterone. We're going to examine why this is even the case. So why do we think that men should be put on estrogen blockers in the first place in a medical establishment, and then why you shouldn't do that. This is going be my best argument and attempt for that, so I know this outside the realm of peptides, but as it relates to peptide,
what do always say first as relates of peptides? Get your hormones optimized first, this one of the common roadblocks and problems men experience when they are on the path to optimizing their hormones. So what I'm going to do in a second is share my screen just before I do so. If this video gets, I don't know, a good response, not even to say like a certain number of likes or anything, but if I see this videos gets a response. I can make an alternative video to what men should do instead of blocking their estrogen. This is just going be kind of the argument of why you should never block your estrogen But I can't make a video, it just would end up making this video
too long. So I cannot talk about that, of how to quote unquote manage your estrogen, which is really the wrong term, but I think in people's minds, that's what they think. This video gets enough comments, likes, and a good response from my audience. I definitely will do a videos on that but we'll see how it goes. But like I said, when we talk peptides, hormones should always come first and then peptide. And this is one of the things that people have to understand on the journey to getting their hormones optimized. As always, you can check out the peptide cheat sheet down in the link in description below and sign up for the email list.
That's where much of the uncensored topics that I can't really say on YouTube or whatever takes place. Then obviously too, can join the fully optimized health group. If you'd like topics like this, Jay Campbell and I do an AMA every single week in there for you guys. And that group's blowing up. I think we have like over 470 members now. If you want to be at the tip of the spear of biohacking, definitely join that group. And then obviously like link to courses and everything will be in the description of video. So without further ado, I'm going to share my screen.
Alright, today's going to be 42 reasons you should never block estrogen. So let's get into it. Why do we block estrogens in the first place? Let's look at this. In 2021, approximately 839,946 men in United States were on testosterone therapy. Now, I realize that is what is reported in literature, but there's probably a good chunk of those men that are not reported because they are doing it through their own means and not through a doctor. Which, you know, I can't necessarily condone but, um, You know all those men probably know more than a lot of doctors out there but basically we can look
at that and say okay. It's hard to get an exact percentage but what I wanted to do is try to collate enough data so from what i could research. It is estimated that a significant subset of these men, probably around 20 to 30% are prescribed aromatase inhibitors. So this is based on clinical practices where AIs are often used to manage symptoms thought to be due to high estrogen levels such as gynecomastia and water retention, which is typically what we associate with high estrogens. Um, also to, uh, I'm going to talk about this a lot, but take it from someone who has crashed their extra, not through the use of an AI,
But just the used of dieting and experimentation on my own hormones. It is not a good place to be. So again, that's kind of my reasoning for this video. I didn't mention in the intro, um, so we're probably looking, i would say for round number of purposes, it's somewhere between 300 and 500,000 men, Uh, That are unfortunately due to a lack of knowledge being prescribed aromatase inhibitors, or either using aromatase inhibitors on themselves without the support of a doctor that are just doing this off label because it's what they think needs to be done.
So there's a large audience of men out there that need to hear this, but basically why do doctors advocate for blocking estrogen. Well, the first one is misunderstanding. So they believe that estrogen is a female hormone. It should be minimized in men, which is absolutely not true. Um, there's an overemphasis on testosterone. And so, you know, typically people think we just want to max out the testosterone levels without considering the need for balance as estrogen in relation to the testosterone. We always want estrogen to confer to level of testosterone in the body.
Also too, there's a misinterpretation of symptoms and we're gonna go into this. So attributing symptoms like gyno and low libido solely to high estrogen without evaluating other causes like insulin resistance is usually a problem. We're going to do a deep dive on that. And then there is the influence of anecdotal evidence of, again, from the bodybuilder world where much of this has leached over into medical practice. Then also to marketing and other quick fixes. Most men today, if they have gynecomastia, which is just man boobs, Uh, they think like, oh, I've got high estrogen because I have man boobs.
Therefore I need to suppress my estrogen either through an aromatase inhibitor or like a natural aromatase, an inhibiter like dim or something like that. And that's not the case. So we're going to get into why that is. Now, how does an aromatase inhibitor work? So basically the AI inhibits the aromatase enzyme, which reduces the conversion of testosterone into estrogen. So, basically we introduce therapeutic testosterone, into the body, and then that testosterone gets metabolized into estradiol and dihydrotestosterone.
And the Aromatases enzyme is what works to convert that Testosteron into Estrogen. I'm not going to talk about DHT in this video, But we're going to look at estrogen and basically what this does by blocking the conversion AI significantly lower the total level of estrogen in the body. And then with less testosterone being converted to estrogen, the thought is that testosterone levels may increase. So we are going raise our testosterone and suppress our estrogen. That is the school of thought. Now, is it high estrogen or insulin resistance?
So here is kind of where this gets fuzzy because a lot of men will get on therapeutic testosterone at 20% body fat or 30% fat, and then they start to have all these symptoms. So basically what happens is they get gynecomastia, which is enlarged breast tissue. They get fatigue and low energy. The get mood swings and irritability. They have weight gain around the abdomen, they have decreased libido and sexual function, and then they water retention and bloating. So, those are the symptoms. Now, how are these actually more a symptom of insulin resistance than high estrogen?
So let's go through this. First, we have gyno. Basically, well, before I get into gyno, basically the idea is that all of these symptoms that men are experiencing are actually a result of that man being insulin resistant, so that when he introduces therapeutic testosterone in his body, that testosterone is over-converting to estradiol causing these systems. So the thought is like, oh, I just need to reduce that conversion rate. No, you need reduce your body fat and increase your insulin sensitivity.
So if you give me, who is around 8-9% body fat, 200 mg of testosterone a week, I convert much less of that testosterone into estrogen than a man who's 28% fat. Because more fat tissue means you have more aromas, tastes, enzymes in the body, therefore you will metabolize more of estrogen, which caused these symptoms. Now, what is the problem there? The problem is insulin resistance, it's not high estrogen. It's what's happening in the body because that body is insulin resistant.
So basically, insulin resistant is often always associated with higher levels of body fat. Increased adipose tissue, especially in the chest area can lead to gynecomastia so fat tissue can also produce aromatase, which is an enzyme that converts testosterone into estrogen which will raise local estrogen levels in and metabolism found a correlation between insulin resistance and increased aromatase activity in adipose tissue. So we do know that the more fat tissue you have on the body, the aromatase enzyme activity you will have in that area.
Now, this leads us into the weight gain and abdominal fat. Insulin resistance promotes fat storage, no surprise there, particularly in the abdominal area, so this is often mistaken for weight gained due to high estrogen levels. Research in Diabetes Care 2011 demonstrated that insulin resistance is a significant predictor of abdominal obesity. No, again, no secret there. Now, let's look at fatigue and low energy. So, this is another thing that men will say is like, oh, I'm on testosterone and my estrogens running wild, and I need to suppress my estrogen because
I have no energy, So is it the estrogen or is the insulin's resistance? So insulin resistance can lead to impaired glucose uptake by the cells, resulting in chronic fatigue and low energy levels. Symptoms often attribute high estrogen. So in 2014, the Journal of Clinical Endocrinology and Metabolism published a study that reported that men with insulin-resistance often experience fatigue in low-energy due to inefficient glucose utilization. Again, it's much more a symptom of insulin resistant than it is high-estrogen.
Then we can look at sexual function. Insulin resistance and visceral body fat is linked to lower testosterone levels and erectile dysfunction, both of which can lead to decreased libido and sexual dysfunction. 2015 study in andrology found that insulin resistance is often associated with erectiles dysfunction and reduced testosterone level. Now, mood swings, this is another big thing, is guys are like, oh, my estrogen's high and I'm crying and angry and all this stuff.
And again, let's look at this. So estrogen, or excuse me, insulin resistance can affect neurotransmitter balance and brain function, leading to moods swings and irritability, symptoms often mistaken for high estrogen. The Journal of Diabetes Research 2013 found that insulin resistances lead to increased incidence of mood disorders and cognitive impairment. There you go. In fact, estrogen is actually cognitive protective. So again, when we look at mood swings and stuff, it's not necessarily the estrogen. It's that you're on an insulin roller coaster throughout the day.
Also, we have water retention and bloating. Insulin has an effect on kidney function and sodium retention, which can lead to water attention and bleeding. These symptoms can be mistaken for high estrogen effects. That's also one of the biggest things. You'll hear a lot of guys on testosterone talking to us like, oh, my estrogen is running wild and I'm retaining water like crazy and stuff. It's like well, are you insulin resistant? And we need to study that. So research in nephrology dialysis transplantation 2012 indicated that insulin resistance can cause fluid retention through its impact on kidney function.
There you have it. So now let's look at this. When men undergo testosterone replacement therapy, there's often concern about increased conversion of testosterone to estrogen via the aromatase enzyme. However, the symptoms of so-called high estrogen during testosterone therapy can actually be more reflective of insulin resistance rather than true estrogen dominance. And that word and phrase is just etched in my mind of estrogen dominates. I would actually want to be estrogen dominant to a point because estrogen is cardioprotective, neuroprotective and lipolytic,
meaning that I burn more fat when I have optimized estrogen levels than when i have low estrogen level. So let's look at testosterone and insulin sensitivity. Testosterone therapy can improve insulin's sensitivity, so men with insulin resistance may initially experience symptoms that mimic high estrogen because their metabolism is still adjusting. So a 2016 study in diabetes care found that testosterone therapy improves insulin sensitivity in men with type 2 diabetes and low testosterone levels. So think about it like this. You take a man that's 30% body fat. you introduce testosterone into them.
In most cases, men with that high of body fat are going to have low testosterone levels, whether that's 300 or 100 or 400 total, it's up for debate, but it will vary. But in most all cases men that are fat will not have optimized levels of testosterone. So what happens is you introduced testosterone, that testosterone gets converted to estrogen at a very high rate And then they think, oh my goodness, I'm taking testosterone and now my estrogen is through the roof.
I've got to suppress my estrogen. Really what is happening is the body is adjusting to a new hormonal state. And in doing so it's over, not over converting, but it is converting more of that testosterone into estrogen, which leads to the symptoms. So that again, causes the misinterpretation of the systems, the which was the following. When men on testosterone experience symptoms like weight gain, fatigue, and mood changes, a crucial assessment insulin sensitivity and metabolic health rather than immediately attributing those symptoms to elevated estrogen levels. So the Journal of Endocrinological Investigation 2015 emphasized the importance of evaluating metabolic and men undergoing testosterone therapy,
noting that many symptoms attributed to high estrogen are actually linked to insulin resistance. All of these high-estrogen symptoms are really insulin resistant. Now, let's move along into the 42 reasons. So hopefully now you can have the framework to understand that it's not about high estrogen levels. It's about insulin resistance. The best thing we can do is get our body fat down to a lower level where the aromatous enzymes in the body are not so high that all the testosterone that's being introduced in is converted into estrogen.
And I, before I preface this, I know a lot of people thinking or like, well, if I am 30% body fat and I'm converting more of that testosterone and estrogen, isn't there a use case for suppressing estrogen? And now we're going to find out why. So here is the 42 reasons. Let me know if you guys like these longer videos, too, in the comments. So I like doing longer video like this. I don't know exactly how many minutes this one's going to run when it's all said and done. But let me if know you like the stuff because I liked doing deep dives in this stuff. And as the world zigs, I'd like to zags like as people move to short form content.
Like doing more long form like content like because because could talk about this all day. Number one, cardiovascular health. A study published in 2010 found that estrogen therapy improves endothelial function in men with cardiovascular disease. There you go. going to rapid fire through these. Bone density, this is huge. This is why a lot of men have joint problems when they are taking aromatase inhibitors and then they need to throw in an anabolic steroid like DECA to help with their joints, which is really just raising their estrogen levels back to where they would have been if they didn't have the aromatase enzyme.
So my theory on Deka, the canoate is that it's actually just raising estrogen levels back to, so I've seen a bunch of guys that are using the testosterone, they introduce an aromatase enzyme, and then their joints hurt really bad because their estrogens are low, then they use DECA to raise their estrogen back up and they're like, well, DecA helps my joints feel better. Yeah, no duh. So 2008 study in the Journal of Bone and Mineral Research demonstrated that estrogen is crucial for maintaining bone density in men. Cognitive function.
So research in journal of Alzheimer's disease in 2015 showed that higher estrogen levels are associated with better cognitive function in elderly men. Mood stability. 2014 study in psycho neuroendocrinology. That's something that sounds like a field that I would want to work in. Psycho neuro endocrineology found that estrogen plays a role in mood regulation and may help reduce depression in men Skin Health, the Journal of Investigative Adrenotology reported that estrogen improves skin elasticity and hydration. I've also noticed now, I know people say this on the flip side, but I will have more acne when I have crashed my estrogen than when i have quote unquote
high estrogen. So funny how that works. Joint health. So study published in Arthritis Research and Therapy 2011 highlighted estrogen's role in maintaining joint health and reducing inflammation in men. Liver function. Research in the Hepatology Journal in 2013 found that estrogen supports liver function and detoxification processes, which is something that all of us are up against in The First World today, is detoxing all the toxins out of our bodies because of the nasty environment. Cholesterol management. This is what a lot of people don't realize.
When they're crashing their estrogen, you're doing yourself such a disservice. A study in Circulation 2010 showed that estrogen helps maintain healthy cholesterol levels by increasing HDL and lowering LDL in men. Sexual function. Journal of Clinical Endocrinology and Metabolism in 2006 indicated that estrogen is crucial, not only beneficial, but crucial for libido and sexual function in men. Number 10, immune system support. So a 2013 study in Nature Reviews Immunology showed that estrogens supports the immune systems and helps fight infections.
Muscle mass. So research in Journal of Endocrinology in 2011 found that estrogen helps maintain muscle mass and strength in men. Again, take it from me who's crashed my estrogen several times before. I am so much stronger. My joints feel so better in my muscles or so more full when I have optimized levels of estrogen. Fat distribution, so here's kind of the kickers, like men think that they need to suppress their estrogen in order to get really dry and lean out, and it's actually the opposite.
So the Journal of Clinical Endocrinology and Metabolism in 2009 demonstrated that estrogen influences fat distribution and contributing to a healthier body composition. For all those fat people that think they have to crash their estrogens to lose fat, you're actually going to do more harm to your fat loss journey in the long run by crashing your estrogen. We have inflammation reduction. American Journal of Physiology in 2012 reported that estrogen has anti-inflammatory properties that can help reduce chronic inflammation of the body, which is something we're all up against.
Energy levels. Again, take it from the horse's mouth. I've done this when I crashed my estrogen before through hormonal manipulation or dieting or whatever, not through the use of rheumatase inhibitors, but just through manipulation of different compounds. I found that estrogen helps me, or I, I find that my energy was crashing today. And a journal, journal of clinical endocrinology metabolism 2010 found the estrogen and helps maintain energy levels and reduce fatigue in men. Hair health. So it's funny is a lot of men, they start therapeutic testosterone and their doctor in conjunction with the testosterone gives them a DHT inhibitor and
an AI, meaning that they block the conversion of testosterone in the two most important metabolites that we actually need from the And they think they they need a DHT inhibitor because it prevents hair loss. That's a separate discussion, but 2008 studies showed that estrogen supports healthy hair growth and reduces hair lost in men. So if you're losing hair on testosterone, I wonder, this is a good question, how many men that claim that testosterone is causing hair loss or on aromatase inhibitor.
That would be a cool stat if I could find out, because I would probably be able to prove that most men have hair lost because they're suppressing estrogen and DHT, not because, you know, they are over-converting the testosterone and the DHTs or whatever they think it is. 2011 study reported that estrogen can improve sleep quality and reduce insomnia in men. There you go. Digestive health. So gastroenterology 2014 found that. Estrogen supports gut health and helps maintain a healthy digestive system in.
18. Funny enough, let's go back to insulin resistance. So you have someone that's fat that is trying to become less insulin resistant and then they block their estrogen and estrogen actually helps them with blood sugar regulation. 2013 studies showed that estrogen helps regulate blood-sugar levels and insulin sensitivity in men. Metabolic function, so a 2012 study in diabetes found that estrogen plays a role in metabolic function and weight management in men. Again, just the list goes on. Pain tolerance, this is pretty funny, not something I expected to find when I was doing research, but Journal of Pain 2011 reported that,
estrogen can increase pain tolerance and reduce the perception of pain in man. Wow, that's funny estrogen, you would think it makes you more of a female, but it actually increases pain tolerance. So when you suppress your estrogen levels, You actually become more Of a whiny B word than you Would if you didn't have estrogen. It's kind of funny. Obviously reproductive health is huge. Andrology 2013 in cave that estrogen is essential for reproductive Health and fertility in men. Here's another thing that also relates to fat loss and energy levels more so than people ever realize.
Journal of Clinical Endocrinology and Metabolism in 2010 reported that estrogen supports healthy thyroid function and hormonal balance in men. So basically, long story short, your thyroid is the master hormone regulator in the body. And if you crash your estrogen, you're thyroid functions starts to suck. All of your hormones, by crashing your estrogens, create a cascade of negative hormones in your body or negative hormon balance of the HRV is all the rage right now. Everyone's got the wearable devices and stuff. I'm honestly ashamed to say I am not like super into that right.
Now I probably could be, but I think a lot of these wearables devices have a of EMF and everything that comes off of them. So I just, before I get into the whole thing of tracking it, I also too want to have like a developed intuition in my body. But anyway, American Journal of Physiology in 2014 found that estrogen can improve heart rate variability which is obviously a marker of cardiovascular health. Mental health, so 2015 study in psycho neuro endocrinology showed that as you can reduce the risk of developing severe mental health disorders and men.
So again, begs the point. I wonder, it's obviously well known in the bodybuilding community, competing using antibiotic steroids, using crazy doses of stuff, and then also just the competition lifestyle makes people almost have a mental health issue. And I wondered how much of that is because they are dead set on crashing their estrogen. But to the point of this video and talking about the context of therapeutic testosterone, you have a lot of guys that get on testosterone that think that's going to be their savior in life, but they're taking an aromatase inhibitor and then they develop mental impairment.
And I can say, I definitely see that. I wouldn't say I have mental health disorder by any means, But when my estrogen has been lower, Growth hormone production. So you know, I had to bring this one up. 2009 study indicated that estrogen stimulates the production of growth hormone, which is important for tissue repair and muscle growth. That's probably a whole different video if you guys would like for me to do some research on that. I could pretty much lay out how estrogen is of growth hormone to IGF, but outside the topic of this video.
Vascular health. So this is another thing, when we look at the endothelial lining, how important estrogen is to the vascular networks in the body. A study in 2011 found that estrogen supports the health of blood vessels and improves circulation in men, which again, sounds, if you're younger, it doesn't sound like a big thing. But as you age, that's the most important thing you can do to help improve longevity and health, so 28, hydration. So the Journal of Clinical Endocrinology and Metabolism 2013 found that estrogen helps maintain proper hydration levels in the body,
which is obviously huge for a bunch of different functions. Reduction of PMS symptoms in partners. Listen to this. Journal Family Practice 2014 reported that maintaining estrogen levels can reduce the severity of PMS symptoms and partners improving relationship dynamics. So if I am reading this right, when I compiled my research, basically that by maintaining healthy estrogen levels in a relationship, it improves relationship dynamics.
I should do a podcast with my girlfriend about this. Check her out, Taylor Reed coaching on YouTube. She teaches women about peptides and fat loss and hormones. Our relationship is so much better when my estrogen does not crash. So take for that, which you will, but estrogen definitely helps improve. Basically, if your partner is on a menstrual cycle and your estrogen levels as a man are out of balance, there is going to be some relationship dynamics that do not bode well for you.
Number 30 bladder function so a study in urology in 2012 found the estrogen supports healthy bladder functions and reduces the risk of urinary incontinence in men. Vision health so Journal of Ophthalmology 2011 indicated that estrogen can protect against age related vision problems and men, which is obviously huge. Prostate health. So Journal of Urology 2013 showed that estrogen plays a role in maintaining prostate health in men. Obviously, it's known that as men age, that's one of the things that deteriorates is their prostate Health. And a lot of times to their testosterone is crashing, their estrogen is crushing, and therefore they begin to have prostate problems,
but it can be protective of that prostate longevity. 2015 study found that balanced estrogen levels are associated with increased lifespan and better aging in Men, which is just that, as they age the quality of life is maintained at a high level. 34, so we have cellular repair. 2012 study indicated that estrogen aids in cellular pair and regeneration of men, which is obviously huge for aging. Again, emotional regulation, you see a lot of these arguments are in favor of maintaining a stable and healthy mood. 2013 study reported that Estrogen helps regulate emotions and reduces stress in men.
36, it prevents muscle cramps. So 2010 found the estrogen helps prevent muscle, cramp, and spasms in men, especially if you're training, that's huge too. A study in 2011 showed that estrogen help support healthy nerve function and can reduce neuropathic pain in man. Overall hormone balance. So again, this goes back to probably some stuff that's tied in with the thyroid, but a 2013 study indicated that estrogen is essential for overall hormonal
balance and homeostasis in men. That's more of like a homeo stasis thing of kind of having this body in a state where everything is regulated and modulated at the proper speed and force and everything. Whereas like if your estrogen's out of balance, old again creates a cascade of problems. Uh, 39 prevention of erectile dysfunction. This is definitely in my experience, true. So, uh, andrology 2014 study found that proper estrogen levels can help prevent erectiles dysfunction in men. Um, which is absolutely true any man that has crashed their oxygen knows that the erection strength with low estrogen versus optimized estrogen is different.
Alzheimer's, so Journal of Neurochemistry 2012 reported that estrogen has neuroprotective effects that may reduce the risk of Alzheimer disease in men. Improved workout recovery, Journal Applied Physiology in 2013 indicated that Estrogen aids in faster recovery post-workout by reducing inflammation and muscle damage in man. So if you want to build muscle and you to have a great physique, don't crash your estrogen because it's going to help in recovery. And finally, the last one, I think everybody can be on board with this, men and women. 2009 study reported that balanced estrogen levels contribute to a healthy libido and sexual performance in men.
So that is it for the slides. And that is 42 reasons why you should never crash your estrogen with the use of an aromatase inhibitor. So if you can get anything from this video, understand that estrogen is very, very important to the physiology and function of not only your body, but your mind and your soul. as it relates to your relationships, your work life and everything, crashing your estrogen can have catastrophic and cataclysmic consequences. So I want you to be aware of that and share this video with someone if you know they're using testosterone or they are thinking about getting on testosterone.
One thing that I tell everyone that goes to a doctor that is prescribing this testosterone is ask them if they encourage the use of rheumatase inhibitors, especially like on a regular basis. If they do run as far away as you can. So hopefully videos like this that I'm making and all the other people in this ecosystem are making educate people enough to where they can understand that because a lot of men, they know they have a problem, but they don't know where to go or where it turns. They go to their doctor And the doctor tells them just get on aromatase inhibitor and that's what they do. So, you know, if you are on testosterone and you're using an aromates inhibitors, hopefully this video kind of opened your eyes.
If you were thinking about it, um, Hopefully this kind will steer you in the right direction. But, Um, If, You know someone that using it. Send this to them to like help show them like, okay, here is the, uh, you know, definitive evidence that you don't want to crash your estrogen. So, um, like I said, I know I talk about peptides all the time, but getting your hormones on check is the most important thing as it relates to getting good function out of your peptide. Um, hopefully this video was helpful to you guys. And again, if it gets enough feedback, can actually talk About like mechanisms and tactics to quote unquote, manage your estrogen,
even though that's the wrong word, But I'm just trying to like meet everyone where they're at. Because there are better things than you can do to use an aromatase inhibitor, the first one being diet and lifestyle. But there aren't things that you could do, especially if you feel like that is a problem in your life or you for whatever reason have like a psychological attachment to thinking you need to manage your restaurant. That's it, you know, always remember that estrogen confers to the level of testosterone in the body. So when we are raising testosterone levels, we want the estrogen to confer protection to those testosterone level.
Unfortunately, when you look at lab reference ranges, The estrogen levels are low because men's testosterone is low. So when you have a population with low testosterone, the reference range of estrogen is going to be low, and so the references ranges are not built on men that have optimized levels of testosterone. Therefore, these reference ranges for estrogen are going not to built for men. If you're a man and you had a 300 level total testosterone maybe you only need your estrogen to 10 or 15. in order to confer protection.
That's not optimal. But if you're a man and you introduce testosterone therapy, you raise your testosterone to 1200 or 1500, You don't want your estrogen at 10 or 15. You would want it to be close to like 50, 60, 70 in in to the level of testosterone in your body. So I'm not going to get into a discussion about levels because everyone's different, but understand that estrogen confers naturally to level testosterone that is in the body, to confer protection. And if you have too high a body fat, testosterone is going to elucidate this to the surface and show you problems.
You're going have these symptoms that are really more symptoms of insulin resistance that the testosterone therapy is bringing to forefront that you may not have experienced before. Uh, that's where this video, uh, thank you guys so much. Don't forget, you know, sign up for the email list, check out the peptide cheat sheet. And if you want to go deeper in this and be able to ask me questions and everything like that, don't forgot to join fully optimized health. So love you, guys much love until next time.