BPC 157 and Cancer Should You Be Worried
This question won't die. Every week I get asked whether BPC-157 causes cancer, mostly because a popular podcaster floated the idea once. So today I'm doing the deepest dive I can on what the evidence actually shows.
Quick disclaimer up front. I can't tell you definitively that anything in this universe does or does not cause cancer. Being human means you're susceptible to it. If you take BPC-157 and later develop a tumor, that doesn't mean BPC caused it, the same way living near a toxic waste plant doesn't automatically mean that did either.
But when you look at the actual evidence, BPC-157 doesn't appear to cause cancer. Let me show you why.
Where the Concern Comes From
BPC-157 is a synthetic 15 amino acid peptide originally isolated from human gastric juice. It's known for regenerative and anti-inflammatory effects. I've used it extensively on myself, my family, and friends, and it does wonders.
The cancer concern is theoretical. And theoretical is just that. Theoretically, my car could break down on the way to the gym. Theoretically, the medicine ball across my desk could fly into my face. Possible, but not likely.
The theoretical case against BPC goes like this. BPC stimulates angiogenesis, which is the formation of new blood vessels. Angiogenesis is also a key requirement for tumors to grow and spread, since they need oxygen and nutrients to multiply.
BPC upregulates pathways like VEGF (vascular endothelial growth factor) and nitric oxide signaling. Both promote new blood vessel growth. So some experts worry it could unintentionally support tumor vascularization.
A few specific concerns get raised in the literature.
- BPC increases VEGF receptor 2 expression, and VEGF pathways are active in roughly half of human cancers.
- BPC enhances endothelial nitric oxide activity, and high nitric oxide levels correlate with greater tumor aggressiveness.
- BPC induces EGR1, a gene linked to cancer progression in prostate and gastric cancer.
On paper, that sounds concerning. Some peer-reviewed authors have explicitly cautioned against BPC use in people who might have an undetected malignancy. Fair enough.
But theoretical concerns are not the same as evidence.
What the Actual Studies Show
Today, no experimental study has confirmed any tumor-promoting effect of BPC-157. The studies we do have point the other direction.
The 2018 colon cancer cachexia study. Researchers gave mice colon carcinoma and treated them with BPC-157. The treated mice had improved body weight, reduced inflammatory cytokines (IL-6 and TNF-alpha), and longer survival. Tumor size in the BPC-treated mice was actually slightly lower than in untreated mice, though not statistically significant.
So BPC didn't accelerate tumor growth. If anything, the tumors grew slower. The mice lived longer and healthier with cancer than mice without the peptide.
Melanoma cell research. An early in vitro study found that BPC-157 actually suppressed the growth of human melanoma cells in culture. It interfered with cell cycle progression and counteracted VEGF signaling in those cancer cells.
This is interesting because it suggests BPC's effect differs between normal tissue healing and cancer cells. In normal tissue, it promotes repair. In melanoma cells, it had the opposite effect.
Long-term safety data. A 2023 University of Cambridge overview concluded there is no scientific evidence linking BPC-157 to cancer. Over 30 years of animal research on BPC for ulcers, tendons, bones, and nerves has produced zero reports of carcinogenesis.
A 2020 toxicology evaluation tested BPC-157 in mice, rats, rabbits, and dogs. No serious toxicity. No genetic damage. No fetal toxicity.
Phase 2 human trials for ulcerative colitis reported BPC was well tolerated with no adverse events. No cancers were reported during observation.
The Mechanism Argument Cuts Both Ways
Critics will point to BPC's growth-promoting pathways. But those same mechanisms can also be protective.
BPC has strong anti-inflammatory effects. It reduces IL-6, TNF-alpha, and oxidative stress. Chronic inflammation is a known driver of cancer in many tissues. By suppressing the inflammatory environment that fuels tumor growth, BPC may actually be protective.
In the cachexia study, BPC blunted the rise in IL-6 and TNF-alpha caused by the tumor. That's a positive signal, not a negative one.
BPC's effects also appear to be tissue-specific. It enhances repair in injured tissues without affecting cells that lack certain receptors. There's no direct evidence that its growth hormone receptor modulation occurs in tumors.
EGR1 is another example. Yes, it's elevated in some aggressive cancers. But in other contexts, EGR1 acts as a tumor suppressor. The biology isn't black and white.
What the Anecdotal Evidence Says
BPC-157 has been used informally for years by athletes, biohackers, and the broader research community. I searched extensively and could not find a single published case report of someone developing cancer specifically attributed to BPC-157.
Given how widespread underground use has become, you'd expect alarming cases to surface if this peptide had a strong tumorigenic effect. They haven't.
Absence of evidence isn't proof of safety. Cancer can take years to develop, and users aren't systematically followed. But the silence is notable.
Why We Don't Have More Research
You might wonder why we don't have better human data. The answer is economic.
You can't patent BPC-157. No company wants to spend the roughly two billion dollars it costs to run proper trials when they can't recoup the investment. Add to that the fact that BPC could heal the root cause of inflammation in many people, meaning they wouldn't need a lifetime prescription, and you can see why pharma isn't lining up to fund studies.
This is why crowdsourced data from real users matters so much.
My take
I do not see a direct causal link between BPC-157 and tumor growth. The theoretical concerns exist, but the actual evidence, animal studies, toxicology data, human trials, and years of widespread use, all point to BPC being safe.
If we put BPC-157 on trial in a court of law and tried to prove beyond reasonable doubt that it causes cancer, the case would get thrown out in five minutes. The most relevant animal study showed BPC-treated mice with cancer lived longer and healthier than untreated mice, with no acceleration of tumor growth.
You have to make your own risk assessment for what you put in your body. But the people confidently telling you BPC-157 causes cancer are not looking at the body of evidence. They're repeating a theoretical concern as if it were a confirmed finding.
That's not how this works.
Full transcript click any paragraph to jump video
Hey everybody, this is Hunter Williams. I hope you were doing amazing wherever you have the world. Well, man, oh man. This is one that just will not seem to die. Today's video is going to be about BPC 157 causing cancer. And yes, I'm going go ahead and say the C word because in some shape or form, probably going end up slipping and saying it once or twice in this video. So if not once, or once why not a thousand times? But the topic of today's video is does BPC 157 cause cancer?
So I guess this came from a very, very popular health and fitness educator slash influencer slash podcaster that talked about peptides once upon a time. And I. Guess one of the messages that was purported in that podcast was the BTC causes cancer. So this is a question I get if not once, at least a few times per week in my question box, which shameless plug, if you want to ask a questions that gets answered on the Q and a videos, head to that link down in the description of the videos and submit a and I have that go to a document to which I will answer
my question box, but some of them are so good or I get them so often I decide to make videos like this answering them. So today I want to do the deepest dive ever done on whether BPC 157 causes cancer. I wanna preface this video by saying there is not one thing in this universe that I can say definitively does or does not give you cancer, Some things may. Being a person means you will be susceptible to cancer. So I want to say that, meaning that if you have a tumor or you think you may have tumor, or if think that you can get a Tumor,
and you take BPC-147 and then you get the tumor. It does not always mean that Bpc-157 caused the TUMOR. Just like whether or not you lived near a toxic waste plant caused a tumour. Or not. I wanna be very upfront and honest in saying that I cannot guarantee If you take something that you will or will not get cancer, that's just kind of a risk that we all have to take living in third entity, I guess, right? But I do want to say when we look at the evidence, if we work and experiences that we have in what little published literature there is around BPC,
and then the larger body work of the anecdotal experience with BCC, we can pretty much say that it doesn't cause cancer. So there you go. That's the TLDR version of this. But what I want to do today is systematically walk through the mechanisms behind why BTC would cause. And then also too, is there any evidence to suggest that And in fact, there may be evidence to suggest that it would be prohibitive towards cancer, but I'm not going to make that conclusion out of what we have to draw on.
But that's going be the topic of today's video. So hopefully this will be fun, entertaining, and educational for you. Hopefully this also be a video that you feel compelled to share with other people that may fear using peptides or they may fear BPC 157 because of what they heard from popular influencers or whatnot. So at the end of the day, again, I cannot promise you whether it does or does not, but I do think when we dig into everything that's going on here, There's pretty good evidence to say that it really doesn't. So that's what we're going to talk about today.
Before I share my screen, just remember that the peptide cheat sheet is down in the description of all videos. Also too, if you want to join the best biohacking community on the planet, join Fully Optimized Health. That link will be down the subscription of the video as well. Thank you guys so much. And without further ado, today we are going learn about BPC-157 and cancer. All right. I am Hunter Williams. Today we're going to learn about BPC and cancer and figure out what is going on here because I want to know. And I think this was actually, even though really already knew the answer to begin with, this is really refreshing and good for me to just do a deep dive in.
So hopefully this as fun for you listening. or watching as it was for me making it. So BPC, if you didn't know yet, is a synthetic 15 amino acid peptide originally isolated from human gastric juice. It is attracted attention for its regenerative and anti-inflammatory effects in various pre-clinical injury models. I have extensively used Bpc 157 in myself and family members and friends, and obviously the amazing folks that I had the pleasure to interact with on the internet. And it does wonder. Despite its experimental benefits, it is not approved for medical use by major regulators like our friends at the FDA and is banned underworld anti-doping
agency due to safety uncertainties, AKA it works. Therefore they ban it. However, one prominent concern is whether or not it might influence cancer development or tumor growth. Now let's look at this from a legitimate perspective. So whenever something is brought up, I really do my best not to throw the baby out with the bathwater and not just criticize things because it goes against the wisdom that I have maybe acquired for myself. So I think the best thing that we can always do is have an open mind and a questioning mind.
And if I found out today that all peptides were extremely toxic for you, although that would be tough and I would have a hard time believing that based on what I've seen practically speaking, I'd course correct. I also think it's important when we hear things like this and especially when they keep coming up to say, even though I don't necessarily jive with that, maybe let's take a deeper look. And that's what we're going to do today. So I think the biggest concern from this really comes from a theoretical perspective. Now, when we look at things from my theoretical. Perspective, it's important to remember that is just that it is theoretical, so theoretically, if I get into my car and drive to the gym or to grocery
store or wherever I'm going, theoretically there's a lot that can go wrong. My car, my cars can break down. My car could get hit by another car. I could hit someone else with my car theoretically. There is an infinite number of possibilities that could go wrong. However, for the most part, based on the risk profile of what I know to exist, I choose to drive around my car because it's better than walking or it is better then riding my bike or its better that riding a skateboard or I don't know, taking a horse and buggy, right?
So when we look at theoretical concerns, just because something theoretically could potentially have an outcome does not mean that it necessarily true. Or it doesn't even mean that it is technically something that is even really likely to happen. And I think the car example is actually much more feasible than what we're going to talk about today. But anyway, I want people to understand that when we look at these things, you can theoretically say something will do anything. There is a medicine ball sitting on the other side of my desk that sometimes I sit on.
Theoretically, that medicine could come hit me in the face right now. No one's there to do it. So theoretically, even though it can happen, it's probably not likely. So no study today has conclusively shown BPC causes tumors, but researchers have noted that the theoretical reasons exist for concern. What Bpc does is it basically stimulates angiogenesis, which is just the formation of new blood vessels in our body. And in doing so, it aids tissue healing. So in the context of cancer, angiogenesis is a key requirement for tumors to grow and metastasize by supplying oxygen and nutrients to malignant cells.
Because BPC up regulates pathways like VEGF, which stands for vascular endothelial growth factor, and nitric oxide, otherwise known as NO, signaling that promote new vessel growth, some experts worry it could unintentionally support tumor vascularization. So basically the thought is, if BPC increases the formation of new blood vessels, that it can also increase the new formation blood vessel to tumor cells, which then could make the tumor grow, then would obviously be bad for us, right?
So let's look at this a little bit deeper. So one review noted that BPC increases the expression of this VEGF receptor to and treated animals and the VF and VFR pathways are active in roughly half of human cancers. Okay. There's a bit of credence there, but BVC also enhances endothelial nitric oxide activity and nitrate oxide is known to stimulate angiogenesis and high nitric oxide levels correlate with greater tumor aggressiveness in various cancers. So, okay, this is looking like it potentially could have some error, right?
BPC can induce the gene early growth response 1, otherwise known as EGR1, during wound healing and elevated EGr1 has been linked to cancer progression and poor prognosis in tumors like prostate and gastric cancer. Okay, so that makes sense. These mechanistic overlaps raise a definite plausible concern that PPC might create a micro environment favorable to any existing cancer cells because of formation of new blood vessels and the growth factors that can contribute to that potentially promoting their growth.
So, By consequence, scientific authors have cautioned against the use of BPC in scenarios where an undetected malignancy might be present. And in a recent peer-to-peer review, the authors explicitly stated that using Bpc may not be the right choice, especially in situations where we are not aware of the presence of cancer cells in our body. Now, I think that's kind of hard to say. It's like saying there may be cancer cells present in your body. There may a rodent living in stomach. I hope that not the case, but there maybe.
And so I that kind hard say, anyway, in other words, if a person had a hidden tumor, BPCs, blood vessel growing properties could in theory feed that tumor. Okay, fair enough. Some experts even go further to speculate on cancer risk. For instance, one scientist noted that because there is so much discussion of this peptide in angiogenesis, regular use of BPC could carry an increased cancer over time if it continually overstimulates blood vessel growth and it must be emphasized that the risk is hypothetical. Nonetheless, these concerns in the scientific community form the basis of peer reviewed warnings that PPC might promote tumor growth under certain conditions,
even though direct experimental evidence of tumor promotion is lacking so far. So again, in theory, this is how it works on paper. In theory PBC could cause this, but as we're going to see today, we are going refute that with some evidence. Today, the experimental has not confirmed any tumor promoting effect of BPC-157. On the contrary, the limited studies we have involving cancer models suggest BPC does not accelerate tumor growth and may even have neutral or beneficial effects,
meaning that they're beneficial for us in terms of reversing the tumor and not growing the tumors. So one of the more prominent studies, and we'll talk about this a little bit later, there was a study done in 2018 called colon cancer by Kong, or I think that's the name of the study. It's probably some longer name, and I just shortened that. But it basically examined BPC in a mouse model of colon cancer, cachexia, which is mice implanted with C26 colon carcinoma, Which causes weight loss slash cachxia. So BBC treatment in this model significantly improved the mice's body weight and reduced pro-inflammatory cytokines, which were IL-6 and TNF-alpha associated
with cachexia. So notably tumor size in BPC-157 treated mice was slightly lower than in untreated mice, and there was no statistically significant difference in tumor volume between the groups. Basically, to sum that up, Bpc did not make the tumors grow faster if anything it actually grew slower with BPC-157 added in, though not enough to reach significant. So I'm not saying that it cured the tumors or even really reverse them, but it did slow down the growth relative to the mice that were not given Bpc.
It did not promote tumor progression despite improving the animal's overall condition. Now let's look at more in vitro research on melanoma cells. So an early in-vitro experiment indicated that BPC might even inhibit tumor cell proliferation under certain conditions. There was a study that reported Bpc suppressed the growth of a human melanomas cell line and culture acting as anti-proliferative agent. The peptide interfered with the cells progression through the cell cycle and counteracted the pro-growth signaling of VEGF in those cancer cells,
It's intriguing because it hints that BPC's effect can differ between normal tissue healing versus cancer cells. In this case, blocking a tumor cells lining growth. While this is just one study, it directly refused the notion that bpc one seven universally accelerates tumor growth, in fact, had an opposite inhibitory effect on melanoma cells in vitro. So again, improve. We see now two studies that show that it reversed or even slowed the progression of tumor. That would normally happen. Beyond specific studies, broad reviews and safety assessments have found no clear link between BPC and cancer in existing literature.
A 2023 overview by the University of Cambridge concluded that despite online claims, there is no scientific evidence suggesting a link BTC and Cancer to date. So this sentiment is echoed by fact that Bpc has been researched in over 30 years of animal studies without any reports of carcinogenesis or the growth of cancer. And various rodent studies of BPC for healing ulcers, tendons, bones, nerves, et cetera, investigators have not observed unusual tumor formation whatsoever so far. So again, when we look at this from an evidence standpoint, it's not really going in the favor of proving that BCC causes cancer.
Also, a comprehensive safety evaluation in 2020 tested BPC-157's toxicity in mice, rats, rabbits, and dogs and found it tolerated well with no serious toxicity. Importantly, it showed no signs of genetic damage or fetal toxicity, in those preclinical tests. Likewise, review of clinical data noted that BBC had a very safe profile with, no reported side effects in early human trials for inflammatory bowel disease, those phase two trials, for ulcerative colitis, No adverse events or long-term issues, including no cancers, were reported during the observation period,
which is interesting because if you take enough of a sample size of any human, you will probably observe some formation of cancer depending on their age and metabolic health. But anyway, while human data is extremely limited, the absence of red flags so far provide some reassurance. So in summary, available research that we have refuse to claim that it inherently grows tumors or causes cancer. And published studies show no promotion of tumor growth. In fact, they show that it may be even protective or at the very least have a neutral effect on tumors. So it is pretty interesting. Now, let's continue to look at this from a theoretical standpoint.
BPC is a multifunctional peptide that interacts with numerous biological pathways, some of which we probably don't even really understand yet. and they also could intersect with cancer biology. So let's continue to look at this. When we look a growth factor signaling, BPC activates several growth-factor pathways, including EGFR and VEGF. It enhances tissue regeneration, but these same pathways can be hijacked in cancer regression. So it has potent anti-inflammatory effects, reducing pro-inflamatory cytokines and oxidative stress while this generally promotes healing. Chronic inflammation create fable conditions for tumor development.
And then BPC stimulates cell migration and proliferation, essential for wound healing, but potentially concerning if these affects us into cancer cells. Then obviously the angiogenesis promotion in promoting blood vessel formation, it's beneficial for healing but theoretically could support tumor growth if present. So let's go into this a little bit more. BPC robustly promotes angiogenesis, which is central to its healing effects. It upregulates vascular growth factors and receptors. And also increases the expression of VEGFR2, a key VF receptor in endothelial cells and ischemic tissues.
Also, like I mentioned, it enhances nitric oxide, Which is a good thing when we look at it in the context of overall health and longevity. And so when we look at these, it's conceivable that BPC could normalize aberrant angiogenesis or strengthen blood vessel integrity in ways that don't favor tumors. The net effect likely depends on the context and dosing, which remains an open question. And I think this goes again to dosage. It goes, again, to cycling. it goes to overall metabolic health of the end user. So it is not always as cut and dry as saying, okay, because of these signaling pathways, its definitive in that way.
One thing too that I think the critics of BPC would say is if you look at growth hormone signaling. So BBC appears to interact with growth regulatory pathways, notably studies have shown it up regulates growth, hormone receptor in certain cells, which is again, one of the benefits that so many people love and know it for. Also, too, in tendon fibroblasts, this led to enhanced cell proliferation where GH was present via the activation of the JAK2 stat signaling pathway. This suggests that BPC can potentiate growth factor signals in cell division in normal cells, and if similar upregulation occurred in cancer cells that
respond to growth hormone or IGF-1, one might worry it could boost that cell's growth. So again, now some of the critics will even say, well, because of ability to upregulate growth hormone sensitivity and receptor density that it potentially could cause cancer the same way growth look at growth hormone and cancer, it's very hard, even though on paper theoretically it makes sense, It's really hard to link the two. Also too, BPC's effects might be tissue specific. So when we look that it enhances repair and injured tissues without affecting cells that lack certain receptors.
There's no direct evidence that Bpc's growth hormonal receptor modulation occurs in tumors, but this mechanism illustrates how Bbc broadly prime cells for growth and regeneration, which could be a double-edged sword in oncology. Again, give credit where credit's due. This is pretty interesting. If we look at BPC and gene expression via the EGR1 pathway, BBC can influence immediate early gene responses. Again, that's why it's so powerful. So it has been found to induce this EGR1 gene-expression in wound healing scenarios along with its core pressure NAB2.
Egr1 is a transcription factor that helps orchestrate tissue repair. Basically, it is just signaling to repair tissue. And then when we connect that to cancer development, it is also implicated in cancers of many tumors, such as aggressive prostate and gastric cancer, so high EGR1 levels. So it's kind of saying, well, if we can correlate that it does this, and that's also correlated with cancer then it would make sense that does, right? Well, maybe not. But by elevating EGR1, BPC might accelerate healing, but if a tumor cell also experiences this EGr1 boost, they could gain a growth advantage. And so the relationship is complex.
In some contexts, EGR1 can act as a tumor suppressor and others are promoters. So it's not always black and white. The key point is that BPC modifies gene regulators like EGR1 that have known roles in cancer biology, warranting further study on what genes BTC turns off or on in various cell types. Again, it is relative to the types of cells and the health of the cells that it expressing to. Now when we look at inflammation and immunity, BPC obviously has very pronounced anti-inflammatory effects. So it reduces excessive inflammatory cytokines like IL-6 and TNF-alpha and oxidative stress and injury models.
And in the cancer Cachexia study, BPCC blunted the rise of IL6 in T and F alpha that was induced by the tumor. And so on one hand, lowering inflammation could actually be protective against cancer progression since inflammatory signals often fuel tumor growth and the mutation of the tumor. And then on the other hand certain immune responses are important for cancer surveillance, so detecting and killing emerging tumor cells in an immune-suppressive effect that could theoretically impair the body's ability to fight nasal cancers.
So the data so far suggests that BPC mainly normalizes pathologically high inflammation rather than causing immunosuppression, but it's precise immunological impact in the context of cancer not fully characterized. So chronic inflammation is a known promoter of Cancer in many tissues. Again, if we go back to cancer as a disease of inflammation and Bpc working to suppress inflammation, then it probably has more of a neutral or positive effect, meaning positive effects for the health of the end user. to suppress inflammation and suppress the inflammatory environment that would then fuel something like a tumor growing.
So that will be the counter argument. And then when we look at that, again, to go back just to sum up, we have angiogenesis promotion. It could potentially favor tumor growth through abundant blood vessel formation or mitigate factors by reducing excessive angiogenesis beyond normal range. You can also create conditions that favor to grow through enhanced growth signals requiring careful evaluation in cancer contexts. To gene regulation, it influences genetic expression with relevance to cancer biology, potentially affecting cellular processes important in tumor development, and then obviously could potentially mitigate factors that tumors exploit by reducing damaging inflammation that contributes to the cancer profession.
So ultimately, the true influence of BPC on cancer likely depends on a complex interplay of these mechanisms. But the mechanistic profile of BPC provides several biological hypotheses for how could influence cancer. So again, if you even break down the mechanisms further, what I wanted to show you here is that yes, you have this theoretical suggestion that it could do this in terms of growing tumor cells. But then if you look at it from the other side of things, based on the tissue specificity of what it appears to do, it actually could suppress it.
And so in one way, kind of like a coin flip, and I think coinflip favors the positive benefit, meaning positive benefits to the end user and negative benefit for the tumor. So it really is when you extrapolate these mechanisms, is it's not as cut and dry as saying like, okay, So let's look at some data that I hinted at earlier, but human clinical data on BPC-157 is very sparse and no clinical trial has specifically evaluated its effect on tumor growth or cancer incidence. Obviously that would be hard to do.
It's hard enough to get studies done on bpc-147 because you can't patent it, therefore no one wants to pay the two billion dollars or whatever the average cost is to to, do studies on it because there's no way to patent and then not going to be able to recoup your money. So it's really an economic equation as to why it is not studying. Maybe two, if you have something that can heal the root cause of inflammation in people that they can take and then not need for the rest of their life, assuming that the can keep the inflammation away through healthy diet and lifestyle, well, then why would you invest a lot of money into studying it?
However, we can look at some of these case reports. Let's look at early clinical trials. So this was in humans. There was phase two trials for ulcerative colitis. BPC has undergone limited human testing for unrelated conditions, providing some safety insights. In this phase 2 trial for Ulcer of Colitis, it was reported to be well tolerated and effective in promoting mucosal healing of the gut lining. Also too, the trial and others in GI ulcer treatment reported no serious adverse effects, and they explicitly noted the BPC's safe profile and absence
of side effects in these trials when they were actually looked at in humans. And although we don't have long-term follow-up data, within the scope of those studies, no participants developed any form of cancer, while those were not designed to detect cancer. they at least indicate no immediate pro-cancer signals initial in human use. So there wasn't even anything that created the signal within those people that would lead one to believe that they could even develop cancer after using. Like I said, we have this cancer cochexia mouse experiment. So the most directly relevant study is this one. Again, I think it was done in 2018. That study BPC acted almost like a supportive care drug.
It prevented weight loss in the mice that were given cancer, colon cancer in this case, and muscle wasting in tumor bearing mice significantly prolonged their survival despite the presence of malignant cells. Kind of interesting, they directly tested it up against mice were giving cancer. and it made their life better. It kept them from losing as much weight, having anemia, and also prolonging their survival. So this is essentially a positive case study in animals. Again, it's just animals, so again, hard to extrapolate to humans. The mice on BPC-157 live longer and healthier with cancer than those without the peptide.
Importantly, even with extended survival, the Bpc treated mice did not end up with larger tumors. to people that didn't have tumors or already had preexisting tumors. One would expect those mice to come faster or people to swim faster, have bigger cancer burden, which was not observed. So this case suggests that BPC did not exacerbate tumor progression and a live organism might have therapeutic value in mitigating cancer or cachexia. Of course, mice are not humans and the specific cancer model was one of cachxia, where the peptides, anti-inflammatory and anabolic effects came into play.
But these findings are encouraging the PPC did not create a runway for tumor growth scenario. So hopefully this is helping you understand and I'm building the case of a conclusion that you can draw on your own. Let's look at the toxicology. This is not as big of a deal, but I think it is relevant to the conversation. So extensive toxicological studies in multiple animal species have not revealed any carcinogenic effects of BPC-147.
It's very easy to do. Just kind of titrate the doses based on the size. So if you're 150 pound human, but your dog's 30 pounds, maybe use the dose that you would maybe like a fifth because it's one fifth of dose, right? But then today, very safe for dogs. So the preclinical safety evaluation 2020 mentioned earlier reported no organ toxicity, no genetic damage and no pathological changes attributable to the peptide, which is pretty interesting. It also found that it did not induce DNA mutations or genetic toxicity in lab assays. So it's unlikely to initiate cancers directly since carcinogens often cause DNA damage.
And that would be a presenting feature or characteristic of it, if it did. And then also from these animal studies, they did not specifically induce cancer when looked at in the absence of pre-neoplastic or neoplactic lesions and treated animals is a positive sign. So these animals safety cases support the view that BPC is not overtly carcinogenic at realistic doses. When we look at anecdotal reports, so BBC has already used informally by us in research community athletes. biohackers, et cetera. There have been annual reports online and to date I have not found one and in the search of using mega search engines, I did not find any published case
reports of a person developing cancer specifically attributed to BPC-157. And again, can we say definitively? No. But again what's the evidence that we can look at? Given the widespread underground use of BPC from all of us nutjobs, one might expect alarming cases to have surfaced if the pet pad had a strong tumorgenic effect. Nonetheless, anecdotal absence of evidence is not conclusive, so the side effect of any cancer could take many years and users might not be systemically followed. And again, really hard to track in the infinite quantum potentiation of all outcomes.
However, some clinics offering BPC-157 claim it is safe and even suggest unproven anti-cancer benefits, which of course we can't back from research and probably never will be able to. And there's been no formal clinical trials on cancer patients that have been conducted. There is scientific interest in possibly using Bpc-172 to counteract side effects of cancer treatments like radiation induced damage, and any future trials would closely monitor tumor outcomes. So, will we get in the future? I don't know. To sum up, relevant data from trials and case studies do not show any Tumorgenic signal for BPC-157 so far, so not only does it not happen in practice,
when we look at all these other pathways and signaling mechanisms to say, well, is it leading to that outcome, it still does not show up. The most pertinent animal case study demonstrated improved survival in cancer-bearing mice without accelerating tumor growth. So again, I can't stress, that's really like, When we looked at this whole conversation, That's the one that we will always go back to. And hey, maybe we can do more studies like that. That would be awesome. And then also comprehensive toxicology data across species further supports a lack of inherent cancer-causing properties. It's crucial to recognize the gaps.
We lack any long-term human data, and no trials have directly assessed cancer risk. Therefore, while the available case and trial evidence is reasserting is not definitive. And at the end of the day, we just need more research. Now, whether that research is done clinically, that would be awesome. But even if it's just in the case of humans using it together. So just sum up, yes, We have theoretical concerns around BPC. There is peer-reviewed research studies more often in animals than there are in humans. but even in those we do not see it. Yes, the mechanisms could indicate that it could be, but just like getting in your car could because there's combustion in the car and it could do it.
In practice, do we see it that often? Not impossible, but again, no. So what do the experts say? Well, the expert are probably going to tell you not to take PPC 157, again because it's not FDA approved and the FDA-approved stamp of approval or whatever you want to call it is the word of God to most people that worship at the altar of science. However, when we look at evidence, and if we're just saying evidence-based, whatever that means, it doesn't look like it. So in conclusion, I will tell you that I do not see a direct causal link between BPC and tumor growth.
Now, whether that's in tumors that already exist or tumors don't exist, which would just be nothing, It doesn' look it does. Again, use your own intelligence. At the end of the day, we all have to make a risk assessment of what we want to introduce to our body and then what After this video, we'll probably never think about BPC and cancer again, unless I get asked a bunch of times, which will probably happen because more and more people are
going to find their way into peptides because of the profound healing power of them. And more more, people will come across content that is created that says, Oh, well, in theory, it could do this. So it's kind of like saying in. Theory. Eating mushrooms could make you sick, but in theory, eating mushrooms can also make your healthy, if that makes sense. Because again, everyone responds differently and we can't really definitively say whether they're healthy or not. For someone that may be healthy for some people, they may not be unhealthy for other people. But on the whole, I think most people would benefit from eating mushroom.
Magical or no. Wink, wink. At the end of the day, It's hard to say that BPC causes cancer and the people that go out and spew that it's really sad because they're not looking at the body of evidence that we have. And hopefully today this has been a good BTC on trial video to look at, okay, what evidence do we. Have? And if we were in a court of law and we we're trying to prove this beyond reasonable doubt, I think this case would get thrown out within the first five minutes. So that is it for the slides.
so to date, this is the most comprehensive video that I have found, hopefully, and you have too on whether or not BPC causes cancer. Again, this is going to be something that people continue to ask as more and more people get exposed to the world of peptides. And I am totally fine in doing video reviews like these because I think it really does spread information that needs to out there in the word, especially among the clickbaity type titles and videos and tweets and shorts and reels and everything get pushed out their sub. Hopefully this is helpful to you guys.
I would welcome your feedback on this one. Also welcome the feedback of the community too. So whether it's in the comment sections, whether its in free communities and private communities, we should have conversations about this stuff. We should conversation about, Hey, I took BBC and maybe had this effect. Maybe it did cause cancer. That's the case, but maybe it caused cancer or maybe an inhibited tumor growth, or it had some other weird effect that wasn't good that you can talk about. The more and more we start to have crowdsourced data around these topics because we're not going to get clinical type data for a lot of these things, the more and more comfortable we can be.
And I think that's part of my, well, I know that that is part my mission here and what I'm doing is to help create these conversations around these. So have conversations in online communities or physical communities and in the comment section, wherever it is out there, say, Hey, this is how I responded to it, because that the best data that we have. As things continue to accelerate the next five, 10 years, we get access to all these amazing compounds out there. They create amazing healing for people and allow people to live amazing lives because they're healthy and they feel overjoyed with their health.
And then they can go out and become prosperous because I feel healthy. these things start to take hold and people can have access to these types of peptides and types drugs and medications that we are working on right now to bring to the market. So I really appreciate you guys. Let me know your feedback on this one and don't forget to ask questions because this video I probably wouldn't have done because I just don' keep up with that much stuff that is talked about on social media because i'm really busy creating stuff. But I would welcome your feed back on that and let me what you thought was helpful or not.
And again, have those conversations, whether it's in the comments or in, you know, the free communities. We have a free community, peptideresearchers.com. You can go there. I don't do any coaching in there, but it is amazing. There's already over 1,000 people and there's tons of conversations around this from newbies to advanced users that talk about this stuff. So I think the more that we can build communities around these topics, this works and this doesn't work. And like I said, my intention and my goal is to be agnostic as to what works, and what doesn' work is just to have the right information.
I think when you look at information systems and how they operate, a lot of people will weaponize information system to create a narrative that feeds their pockets or feeds whatever agenda they have. Again, that's not my go. We all have to exist, right? But I think the closer we can get to better information, the more it helps drive conversations about what ends up being true. So I really appreciate you guys. Thank you again from the bottom of my heart. I am so excited and passionate and grateful that every single day I get the bring messages like this to you, guys, and it's really a dream come true So
thank you guys so much. I love each and every one of you in whatever shape or form you support, whether it's watching video, liking the video commenting on the videos, joining communities, buying products from the companies I own or work with or support or whatever. Thank you, guys, so. You really are, I want to say this because I used to be one the people that would just listen to the podcast, right? And I really didn't think I had a hand in, whatever this whole ecosystem is, biohacking, longevity, anti-aging. performance, handsome, whatever. And I used to dream about being able to get to do that.
I really want to pass the message on that if you're someone out there that's listening to this, you really do have a hand in this. The very nature that you are listening me talk about this on a video means that have an opportunity to help spread the messages because there's so many people out on the planet right now that don't even know what a peptide is and they don' even any of these things. So understand that yours is important to me. Not saying it's going to be your job one day or anything like that, but understand if are you listening this right, now you have hand and helping spread this information and making the world a healthier place, which makes the word more prosperous. It makes people happier and lifts the collective consciousness of the planet.
So that is it for this one. I appreciate you guys love each and every one of you and thank you so much. And I will see you in the next one, please.