Cortagen Review My Surprising Results for Brain Mood

0:10 Hey everybody. My name is Hunter Williams. I hope you're doing amazing wherever you are out in the world. Today's video is going to be about an injectable bioregulator I have been using called cortigen. So this is technically the injectible bi-regulator for your brain. You may or may not be able to get it orally, but for the most part, at least here in United States, you will see it sold by research chemical companies as an injectable formulation.

0:40 bioregulator for your brain. But I have been using serolutin for a while and I recently started using cortigen. I really liked my response to it. So this is going to be likely one of several videos that I do on injectable bi-irregulators because right now there's really no public underground information about how to use them, how chemical signaling molecules as some of the other peptides because they're bioregulators, but they do pretty specific things

1:21 that are pretty cool. And so I'm going to be making more about these. There's tons of different injectable bi oregulars as there are oral bi regulators, which you can find from bio longevity labs. But I want to go ahead and get this video out because this is one for the brain and I get asked all the time about cognitive enhancement, nootropics, and then from that side of things, then also from the dementia slash neurodegeneration side of things. And this is a peptide that depending on how you use it can actually help with all those areas. So what I'm going to do today is just walk through what it is, how to dose it, and how use properly, because more or less all these injectable bioregulars

1:55 will be the same. I actually am in the process, hopefully it's done very soon, of updating the peptides cheat sheet to have all of these bi oregulators. Definitely will announce that once it ready. The process of doing that right now. depending on when this video gets launched, it may or may not be active. But anyway, I will definitely let you know. And if it is, It'll be down in the description below, but appreciate you guys. Don't forget to check out the peptide cheat sheet, which hopefully is updated. If not by the time of this very soon, and then also check it out fully optimized. So without further ado, let me share my screen.

2:25 All right, I'm Hunter Williams. And today we're going to learn about cortigen, which is the injectable bioregulator for the brain. I've been using myself. Really like it. Let's get into how you can turbocharge and improve your brain with cortigens. So it's basically a synthetic tetrapeptide derived from the Brain Cortex peptides classified as a peptide bi-irregulator. What it does is exerts effects at the molecular level by modulating gene expression and protecting cells from stress. Now that's pretty common among bi regulators. This one specifically is going work on the Cortigen has been shown to upregulate certain genes involved in cell survival and repair,

2:59 notably increasing the expression of interleukin-2, otherwise known as IL-II, in immune cells and inducing genes like heat shock proteins, which everyone knows from the benefits of being in the sauna, that help neurons cope with stress. And it can also alter the transcription of hundreds of genes and a genome-wide analysis in mice found cortisone treatment change expression of over 200 genes in cardiac tissue, affecting pathways of stress response, metabolism, and growth. And the broad genetic influence is partly due to cordial epigenetic action. It can induce decondensation of heterochromatin.

3:31 So that five times fast thereby reactivating silenced genes. For instance, ribosomal DNA that are important for protein synthesis and cell function. So let's look at some of the mechanisms. At the cellular level, it basically exhibits an antioxidant and anti-apoptotic effect. One, we can look mitochondrial protection. It helps maintain mitochondria function and ATP level in neurons in the brain while preventing excessive lipid peroxidation and oxidative damage in brain. When we look at that in the context of neurodegenerative disease, that's going to be huge in helping, one, prevent it from ever happening,

4:07 but two, if that starts to onset on the body to, be able to reverse it. So by scavenging free radicals and boosting antioxidant defenses, it shields neuronal components like lipids, proteins, and DNA from reactive oxygen species, specifically in brain. And also interferes with apoptosis, which is basically programmed cell death. In studies, it's been shown to inhibit caspase enzymes and upregulate BCL2, which is an anti-apoptotic protein, while downregulating proapoptoic factors.

4:37 So basically it is keeping brain cells from dying. helps neural cells survive under stress or injury. So additionally, cordia appears to promote neurotrophic effects or just the growth of new brain regions and cells. And it also stimulates neurogenesis by encouraging proliferation of neuronal progenitor cells and enhancing synaptic growth, which aids in brain repair and plasticity. And so there's also evidence that cortigen and related peptide support, uh, neurite growth and neural network formation, possibly in concert with neurotrophic factors and also may modulate neurotransmitter systems.

5:11 For instance, some reports suggest they can influence cholinergic dopaminergic and serotonergic activity, which could underlie improvements in cognition and move though the exact receptor interactions and brain under investigation. I can say firsthand, It's not super pronounced, but there is definitely a noticeable benefit to your overall mood when using cortigen. And really within the first one to two weeks, it wasn't maybe the 1st day, within 1-2 weeks of using it, which you don't use these for prolonged periods of time, definitely had an effect.

5:41 Cortigen's mechanism of action involves gene regulation, reduction of oxidative stress, prevention of cell death, and stimulation of neural growth, collectively contributing to its neuroprotective and regenerative effects. Is it the strongest cerebral isin? No, but it definitely is pretty powerful. So let's look at neurological injury and neurodegeneration for a use case. In post-traumatic peripheral nerve injury, which I know a lot of people suffer from because I get messages from them, cortisone significantly improved the structural and functional recovery of nerve fibers.

6:13 For example, in a sciatic nerve transection model, cortisone treatment accelerated axonal growth, increased conduction velocity and regenerating fibers by 27 to 40%. And similarly in spinal cord injury models, it sped up nerve tissue and regeneration, improved motor function recovery, likely by activating genes for neuronal repair and reducing inflammation in the injured tissue. So these findings support its potential use in neurotrauma rehabilitation. Like I said, It also protects against neurodegeneration. Conditions like Alzheimer's, it's exhibited neuroprotective effects by reducing beta amyloid toxicity and inflammation in the brain,

6:49 leading to improved cognitive function in animal models and its ability to protect neurons from oxidative stress, like we talked about, and apoptosis suggests a therapeutic angle for diseases like Alzheimers, Parkinson's or dementia. 2011 study of chronic cerebral ischemia, which is insufficient blood flow to the brain. The peptide also prevented memory deficits and preserved neuronal health. So both Cortigen and its parent extract Cortexin, what you may have heard of. accelerated recovery of impaired behavior in ischemic grafts and prevented excessive lipid peroxidation in brain tissue,

7:25 thereby maintaining antioxidant activity. So this shows us that cortisone could enhance neuroprotective therapy and stroke or chronic ischaemia by safeguarding neurons from oxidative damage and metabolic failure. And there have also been exploration of corticone in chronic brain hyperfusion and vascular dementia models. Again, noting it's improved cognitive outcomes in neuronal survival. Pretty powerful in that sense. Let's look at the mental health side of things. There's this other bioregular peptide called Cortexin. Cortaxin is the bovine brain cortex polypeptide mixture from which Cortogen was derived.

7:57 So Cortagen is derived from Cortxin and Cortixin has been used clinically to improve memory and attention. And cortigen as a result is the synthetic fragment has also been tested for similar indications. So in animal models of cognitive impairment, cortigens administration led to enhanced learning and memory performance. And this pro-cognitive effect also was attributed to its neurotrophic and neuroprotective properties, which help maintain synaptic plasticity and neuron viability in the face of neurodegeneration.

8:28 It has also shown an interesting profile in effective behavior. So a study on mice found that low dose cortisone increased exploratory locomotor activity without causing anxiety like effects. There was also acute and repeated cortisone use produce mild psychostimulant effects, boosting movement and vitality, but with no adverse impact on anxiety or emotional behavior. So this contrasts with the broader cortex and extract, which at higher doses could induce hyperactivity and anxiety and is known to do with repeat use. From that sense, does it mean corticone is weaker?

9:00 Maybe, But it also doesn't induce the anxiety at a higher dosage like the cortex does, Which is interesting because again, if you look at the whole Neutropic slash cognitive enhancement realm. That's always the balance and. kind of scale that we're trying to weigh, right? It's how much do I increase things at the risk of creating anxiety and jitters and those things, but then also giving myself enough of stimulation to feel good. And then, also too, there have been findings that just cortisone might have a role in ameliorating fatigue or depressive symptoms as its energizing effect

9:31 could potentially benefit mood and motivation. Researchers have noted that such behavioral stimulation, the absence of anxiety side effects could be useful in treating depression or anhedonia symptoms. While human use data is still limited, the experimental uses indicate cortisone therapeutic potential in, one, neurodegenerative disease, two, ischemic brain injury, traumatic brain injuries, three, peripheral neuropathy, and then obviously mood disorders. So in Russia, in some clinics, corticone and cortexin have been used or proposed as neuroprotective agents in conditions like Alzheimer's,

10:04 Parkinson's post-stroke recovery and multiple esclerosis, though we don't really have large scale data, especially in the Western world. Now, like I mentioned, there is this mood and brain energy. I will say from personal experience, it definitely is there, but it's not overstimulating and you just feel more focused in the zone. But you feel like yourself rather than someone else. And I know for any myself or anyone that's taken different or various new tropic compounds, some things work, to make you more of yourself.

10:36 They kind of maybe alter your personality or alter, your mood, and you may be able to get more work done or whatever it is, but it's not the best. So like we talked about, there's this increasing activity without anxiety. Acute and subchronic cortisone administration, which was around 0.03 milligrams per kilogram, significantly increases locomotor activity, without causing anxiety or agitation. And so this is where it a little bit different than Cortexin because sometimes Cortextin can cause this while Cortisine does not have any anxiety like behavior that we have seen or been able to measure.

11:07 Also too, like I mentioned, there could be a potential for mood disorder. So for people that have low dopamine or low serotonin or whatever it is, again, I think a lot of times that's a hormonal issue. We could potentially use cortigen to be beneficial in the employment and treatment of effective slash depressive symptoms. It overall could definitely I think at least in the background be something alongside hormone therapy alongside all the other biohacking slash life intervention techniques that I would talk about be Something that helps with this mood. I Think it's pretty cool if you look at it just as a background thing to run once or twice per year to help with brain health and to help with longevity

11:44 slash anti-aging. So its ability to favorably adjust gene expression and epigenetic markers in aged cells suggest it could slow cellular aging, which obviously we know is good. And it also, cortisone treatment in lymphocyte cultures from elderly donors reactivates silenced genetic regions and increased protein synthesis activity. This is associated with more youthful cell function. It basically is remodeling and reverse aging cells. Also, there's a little bit, like I mentioned earlier, and it wasn't a typo, is the cardiac protection.

12:15 So, cortisone also had beneficial effects on the aging heart in animal studies. It upregulated stress defense proteins and regulated genes involved in cell survival and tissue repair and cardiac muscle. Now, my gut tells me that that may have something to do with the fact that we have neurons in our heart, just like we had neurons on our brain, so we can have the neurons of our gut. And so, in working on those specific cells and tissues, I think that's probably where you're seeing some of the benefit. So it definitely can serve and does serve as a longevity booster by helping maintain brain heart and immune system function as the body ages.

12:49 So while we don't have, again, a lot of clinical data on it from a mechanistic standpoint is doing things. Let's look at some of the published research that I could find a 2001 study in the Bulletin of Experimental Biology and Medicine, Analyze Cortigen's Neuroprotective Properties and Models of Oxidative Stress. So I found that cortigen protects neurons from oxidative damage, likely by upregulating heat shock proteins and reducing oxidant stress markers in neural cells. Now, I will say I don't feel any more body temperature heat on cortigen, but at a cellular level, it's driving these heat shock proteins.

13:24 So the peptide's ability to induce stress response to proteins suggests a mechanism for protecting brain cells in neurodeteriorative conditions. Also from that same journal in 2002 there was a study that investigated short peptides effect on immune cytokine genes and it showed that cortigen stimulates the IL-2 gene expression in mouse splenocytes even without external immune triggers. So those are less potent than some other peptide like epitalon or velon which are better at doing that. Cortigen still significantly increased IL2 mRNA levels.

13:54 This shows the cortigens immunomodulatory action is powerful linking the peptide to a potential regulation of neuroinflammation and helping mitigate neuro inflammation. A 2003 study looked at cortisone's impacts on nerve tissue regeneration after injury. So in animal models, corticone markedly accelerated nerve repair. And again, go back to that neuropathy. conversation with treated subjects showing faster recovery of motor function after peripheral nerve damage and even improvements in spinal cord injury. So the proposed mechanism that they thought to be working was the activation of genes related to neuronal growth and suppression of post-injury inflammation.

14:30 So this reinforced cortigen's therapeutic potential in trauma or surgical nerve damage. We have a 2004 study where a large-scale transcriptomic analysis was done on mice given cortisone. So out of around 15,000 genes analyzed, cortigens altered expression of 110 genes in the heart, Cortigen altered expression of those 15,110 genes in the heart used as model tissue. Notably, it upregulated genes for stress resistance and development. For example, Hechoc protein HSC70, BMT2, and WNT4, EPS15 and Eps15RS were all affected.

15:09 So the maximum gene expression changes were around a five-fold increase or a three- fold decrease. Basically, in simple terms, that cortisone can produce measurable genomic effects associated with anti-aging. So they concluded from this study that the corticone has both common and unique gene targets that likely underlie its multi-system benefits. Three more studies looking at 2011 in Open Neuropsychopharmacology Journal. In this pharmacology study, researchers tested Cortexin and Cortigen in mouth behavior models.

15:41 So acute cortigen administration increased locomotor activity like we talked about before in exploration without sedative or anxiolytic effects and also enhanced movement both on the first day and after five days of treatment indicating a sustained stimulatory effect over time, even five days after treatment, and it has not provoked anxiety like behavior, or even after repeated dosing, it had no side effects on emotional effect of profiles. So by contrast, the Cortexin extract showed some dose dependent anxiety reduction acutely and mild anxiety increase on repetition.

16:13 Basically this showed that Cortigen's potential as a safe cognitive stem cell, slash anti-depressant adjunct. It does exist. And it noted the peptides at very low doses with no toxicity. Another study in 2011 from the St. Petersburg Institute of Bioregulation and Gerontology, which is the original mother school of bioreglers reported that cortisines affected models of neurodegenerative disorders and memory loss. So, corticone administration led to improved learning and and experimental animals with neurodegenerative changes.

16:45 It was suggested that cortigen's neurotrophic properties and antioxidative and anti-inflammatory effects contributed to the cognitive improvement scene. So this study showed that it could benefit patients with memory impairment or diseases like Alzheimer's or dementia, although it was just a preclinical assessment. Lastly, the most recent I could find, 2015 International Journal of Peptide Research and Therapeutics focused on cortigen's ability to reverse age-related epigenetic changes in human cells, to emphasize cultures from elderly donors who are 80-plus years old, were treated with cortigens and molecular cytogenic

17:20 analysis were performed and the peptide induced deconsensation of aged heterochromatin, which effectively unrolled tightly coiled DNA regions. So specifically, cortigen activated ribosomal DNA changes, or DNA, changes normally silenced with age by opening up the nucleolar organizer regions and it reactivated other genes that had been repressed in aging cells. so importantly, it did this without affecting the stable structure of heterochromatim that could cause genomic instability.

17:50 So these findings are significant because they demonstrate a tangible gene rejuvenation effect or reversing of aging effect. Cortigen can epigenetically unwind age-silenced genes, potentially restoring youthful protein synthesis and cell function. So the authors of this study proposed that this remodeling of chromatin might underlie cortigen's geroprotective effects and could be harnessed in therapies to prevent age-related pathology. So again, long, very wordy way of saying that cortogen works at the genetic level to reverse aging and signal basically age stress genes to reversed age,

18:28 which is pretty cool. Now everyone's favorite, the dosage, right? So you probably are either skipping to this right away or have been waiting for this because that's all great. You all know it's well and good, but what does it matter? So typically, cortigen's gonna come in a 20 milligram bottle. Now for a beginner slash maintenance slash biohacking protocol, I would use two milligrams a day. I don't have any outstanding neuropathy or outstanding neurodegeneration that I am aware of at this moment in time.

18:58 It did get hitting a lot in the head growing up when I played football. But just for testing, for someone that is just looking to run this as a background protocol and to have some mild cognitive enhancement. Two milligrams is great. You can use two milligrams per day for, for 20 days in a row is what I would do. So basically you would need two or two bottles. Yeah. And because there's 20 milligrams in the bottle. Did cortigen improve my brain to do math? Well, I've already been pretty good math, but sometimes when you're doing public math hard, it becomes fast or harder to it fast on your feet because you

19:31 want to make sure you are not doing it wrong. So anyway, we always joke about in the live streams with Taylor that Taylor doesn't do public. And rightfully so most people shouldn't. However, the purpose of this would be general cognitive enhancement, biohacking, improved focus, mood, energy, and neuro protection. Now for an intermediate protocol, which would for suboptimal brain function, chronic brain fog, memory enhancement moderate cognitive dysfunction or mood related concerns, I would have to dose. So I will do five milligrams a day for 30 days. If that dose, you're going to need, what's that total? 150 milligrams. You're gonna need seven or eight bottles of it, but you'll probably going notice a much more pronounced effect from doing five milligram a days than you

20:06 would from two milligrams today. And then for advanced, this would be for people with severe conditions like dementia, Alzheimer's, traumatic brain injury, concussions, severe neurodegeneration, or acute neural repair needs. You're going to do 10 milligrams a day. So that would basically be one bottle every two days. And I would assess the tolerance, definitely start for doing 30 days and then up to 60 days, so yes, that's going be more pricey, but that is going in the severe case where you are going need that. I will do ten milligrams per day, And then after those initial cycles, see how you do.

20:36 I would take at least one, two months off. Obviously, if it's a severe condition, you could probably continue. It's not going to have any deleterious effect. But what I will do is take it atleast one to two month off and then if you wanted to redo it, You could do it two to three more times per year. Do five to ten milligrams the other day. You can run the same cycle. you just might not need as much. and then do that for 10 to 20 days. So I would take at least one, two months off after doing each of these protocols, depending on the severity of the issue, obviously. But this is going to help maintain cognitive improvement, neuroprotection, anti-aging, cellular rejuvenation, and prevent relapse and regression.

21:10 Now, as far as timing goes, I wouldn't inject in the AM or PM. It doesn't seem to matter. Doesn't make me more awake or more sleepy. it just kind of enhances overall function. You can take it at night. you might notice more benefit at I will say my aura ring sleep scores, among other things that I've done, have improved greatly when doing this. So maybe it's just anecdotal, but it does seem to work. And then I would do sub-q. You probably could do intramuscular if you wanted to maybe notice a little bit faster of an onset effect. But I do some subq, so AM or PM, pick your preference, and then do it sub q in a fast state.

21:46 I'm going to even go as in depth to say, if you're going use this, what I would do, you going get a 20 milligram bottle, almost all that I could find or sold in 20-milligram bottles. You would put two milliliters of water. It's now 10 milligrams per milliliter. So if I wanted to do two milligrams, I will do 20 units on an insulin syringe. I'd add two-millilitres of, water I'll do 0.2 mLs because that's one-tenth of the 20 milligrams. Two milligrams is one tenth of 20 Thus I'm going to do one 10th of the total amount of water for one dose.

22:17 And that's going be the beginner dose now. If you were doing the five milligram dose of same mixing amount, you would do 50 units and then the advanced dose would be a hundred units. But if you didn't want to that much, You could obviously titrate the amount water you use. So very simple, very plain screenshot that record it, listen back to it at 0.25 speed because people say I talk too fast. Some people probably listen to me at three X speed. But anyway, that would be the dose. And I will say I've got more videos on injectable bioregulators coming. This is kind of the standard dose pretty much for every bi oregulator that's injectible that you would do to get the benefit.

22:50 Again, it kind goes to that beginner, intermediate, advanced scheduling and dosing. So that is it for the slides. And that is my analysis slash comprehensive summary of cortigen. So it's pretty powerful, again, in terms of nootropic effects. It's not going to be like I'm a daffodil or a racetam or anything crazy like that. But I really like how I have felt on this. I feel good from a mood standpoint. My mood is very stable. Not super angry or super down either way. Which I don't really that anyway, but we all have things in life that kind of will stress our brain out, so to speak.

23:23 And I think when we look at this, probably the most powerful component slash angle on the injectable by regular side of things is stress resilience. And if we look at stress, the brain, we all go through things in life, emotional trauma, mental trauma. Physical trauma even in my case, lots of concussions from playing football, that cortisone could benefit. So maybe I had a more pronounced effect because I do have a history of traumatic brain injury, none that were recent. But it does seem to work pretty well. And I won't say that it turns me into a robot supercomputer, but it definitely makes me have a better mood.

23:56 It definitely make me think better, think clearer, I think more logically and feel better overall. So I plan to use this at least a couple of times throughout the year, again, adhering to that schedule, which I outlaid and designed. But use as needed. I Think at the very least, they're relatively affordable. The perfects are not as pronounced as something like cerebralisum, but these injectable bioregulators, particularly cortigen, do seem to have pretty good effect. And I think if you were looking at building a stack, you could definitely throw in some other things around cortagen that would help with it.

24:27 So hopefully that was helpful to you guys. I look forward to your feedback on this one. Let me know if use cortogen or you plan to use it and just leave those down in the comments. But I appreciate you, guys, again, I make sure at the end of every video, let you know how much I am thankful and grateful for everyone out there supporting the channel. And again, whether you never comment or interact with the video, but you just watch again. I appreciate you too. We are all part of this.