Pinealon: Updated Benefits, Mechanisms, and Dosing

0:09 Hey everybody, this is Hunter Williams. I hope you're doing amazing wherever you might be in the world. Today, I am doing an update video to one that I did a long time ago.I don't even remember what it was, but it feels like it's probably been at least two years. And it is going to be about the peptide or the bioregulator peptides called Penelon or pineal on I'm not sure exactly how you pronounce it,but contrary to what a lot of people think,this is actually not the Peptide bi-regulator for the pineo gland, although it does work on the brain and the central nervous system. actually epitalin works more specifically on the pineal gland or pinea line, however you say it.

0:42 I'll probably say both during this presentation as I'm just going through a stream of consciousness and everything. But I love pinealon. It is one of my favorite peptides. That wouldn't put it in like the top top five or maybe the Top 10, but it's still a really cool one nonetheless. It's actually one I know for me helps a little bit more on the circadian rhythm side of things, probably helps with sleep just in my own personal experience. We're going to walk through everything that it does today, but then also to a bit on performance side. So it kind of just up regulates everything. It is hard to pinpoint one specific thing, very similar to the way that SS 31 just kind makes you feel better and kind to makes everything work better.

1:20 Pinealine does something very similar. And I think for long-term, when we look at long term, there's a lot of data around longevity and a lotta data, around healthy brain aging or having good memory and good focus as we age. So I'm a big fan of it today. I wanna walk through the mechanisms, the doses, benefits and everything, and then give you my own personal insight, just really based on my experimentation and what I've kind of advised. other people to do in the past. So that's what we're going to talk about today. Thank you guys so much for tuning in. The overwhelming amount of support that I've been getting recently is awesome.

1:51 Just make sure you're on the email list. That's the best place to stay in touch with me. Fortunately enough for me, I was able to get my Instagram back, which is pretty cool. Hopefully I can get YouTube back. We're still working with some warriors and everything on that, but Make sure on the email list, that's the best place to stay in touch with me if I get kicked off of any more platforms. And then also to check out Axion Collective, we have a private group. We do live calls every Thursday night with the group where you can come on live and ask questions. It's awesome. we an amazing community there and you check the forum. You can message me directly and obviously come to the call. So check that out. But without further ado, We're going to jump into the slides and today learn about Penelon.

2:25 All right, today we're going to get into it. We're gonna do a deep dive on Penielon. So strap in, I think this is gonna be a fun one. And even if you're a more veteran peptide user, especially the injectable version of Penialon is going be one that you might not be familiar with. It's not as popular, but I it's really cool. Hopefully this video, the theme of this year is talking more about some of these adjacent peptides that are not in the mainstream that work really well. This is definitely one of them. So Penelon is a synthetic tripeptide developed through Russian anti-aging research and as a peptide bioregulator for slowing aging and supporting brain health.

2:58 Particularly it was originally isolated from cortex and you've probably heard of that bi-regulator before and it's related to pineal gland research. It's administered via injection. You can find oral forms of Penilon, but For the intensive purposes of this video, I think the injectable version is much better. Not that the oral version doesn't work, but obviously as with most things and almost everything, injection is going to be better, obviously not FDA approved, But it's been used experimentally in Russia for decades by anti-aging practitioners for cognitive enhancement and neuroprotection. So again, three amino acid sequence, we're going talk about the Injectable.

3:29 It does cross the blood-brain barrier and there are lots of anti aging effects of it. Let's look at some of the mechanisms of action. And like most bioregulators, you're gonna see similar themes here, but we'll talk about what it does specifically. Basically, when you inject Penelon, it penetrates the cells and nucleus to bind to the DNA and RNA, which influences MAP-K and the ERK pathways. It also down-regulates pro-apoptotic factors, known as Caps-Base 3-P53, while up- regulating antioxidant enzymes, SOD2 and GPX1.

4:01 A little thing about P53. We're going to see that too another video I'm working on right now on Fox04DRI. So interesting that there's a kind of little bit of sisterhood between Penelon and FoxO4, obviously very different things, but there is an antioxidant effect of Penilon, which is pretty interesting because not all of the bioregulators have this, and so dose-dependently suppresses reactive oxygen species and neurons in the brain under oxidative stress. It also protects mitochondrial function and cellular energy balance specifically in Also as anti-apoptotic actions, probably a word you hear all the time,

4:37 apoptosis. What does that mean? Basically it reduces brain cell death. It also prevents the loss of dendritic spines in the cell and normalizes over-activated cell-death pathways. And also keeps caspase 3 activity at near normal levels instead of letting it progress into inflammation and aging. Then we see neurotransmitter modulation. I think this is going to be from a practical takeaway. One of the things that you will notice about Penelon is that it increases serotonin expression, it enhances pineal gland function and melatonin production.

5:08 It also aids circadian rhythm and regulation and reduces neuronal hyper excitability. So again, working kind of all across the brain on some of those areas, which in turn is gonna help with some these neurotrasmitters. Now let's get into the benefits. Practically speaking, what does that look like? Obviously something's working on the brain. We have cognitive enhancement. So the first thing we see is improved memory, learning, and mental clarity. I can attest to this is definitely something I would say after kind of a week or two of use, you kind just wake up and it's not,

5:38 again, a nootropic effect, but still powerful nonetheless. Animal studies have shown retained cognitive function under adverse conditions like diabetes or prenatal stress. Users report sharper memory, faster perceptual motor responses, and higher mental performance. And then we look at neuroprotection. It slows brain aging by supporting neuronal survival and regenerative capacity in trials with 32 older patients. Penelon improved central nervous system activity and slowed biological aging markers.

6:08 It also protects against active distress, impaired blood flow and neuroinflammation. So pretty cool. They are on the cognitive enhancement side of things. Let's look at a sleep mood and wellness benefits. One of the biggest things I think relative to maybe even epitalon, which does this a little bit, but I thing Penilon is better on those circadian rhythm side things, it improves sleep quality and normalizes sleep wake rhythms by restoring Penial gland function. It also increases natural melatonin release and promotes deep REM sleep stability without grogginess.

6:39 I think it's doing, to me, more in that realm than epitalon necessarily does, even though epitalin does that a little bit. And that's particularly powerful when you talk about travel, when talk jet lag, you talked about night shift work, anything along those lines is going to work really well for that. We also see that in VIP. So VIP would be another peptide to pair. It works well with that we also seen mood and stress resilience that boosts serotonin expression for improved mood, and reduced anxiety and also modulates cortisol.

7:13 and the HPA axis activity to increase stress resilience. And users report feeling calmer yet more mentally alert. I think that's huge, especially during periods of high stress in our lives. Or if we've had chronic stress that has been elevated for a long time, it's going to modulate some of the cortisol there, which is nice, and then also increase our resilience to stress. Always tell people, It's not necessarily stress, that is bad. It is our ability to cope with stress and our resiliency to that stress that is usually the problem. And sometimes when we don't have the tools, we can break under that stress.

7:44 Then we look at general wellness. It is a systemic antioxidant that confers lots of health benefits as an antioxidate. So it improves metabolic and hormone balance, enhances exercise recovery and vitality through better mitochondrial function. Lots of things that's going on. Uh, it has also been explored for supporting visual and hearing functions. I think for eye health, this is definitely one of the ones top three to five that I would put in there for high health. And also helps with hearing as well. This is one I get asked about tinnitus a lot. I think PPC and TB 500 can help with tennitus, but I Think one that people probably overlook is Penelon.

8:15 So if that's something you're dealing with, it's worth a shot because it was relatively cheap to try, especially compared to some other peptides. And some reports suggest benefits for immune system regulation, though data remains limited. Most benefits are derived from early research or small scale trials. And while promising, obviously they are not big ones because a lot of this data is coming from Russia. Let's look at some of the data talking about that. So 2012 prenatal stress, 10 micrograms per kilogram daily for five days. protected offspring, brain development, preventing learning and memory deficits and rats exposed to high homocysteine, which is interesting.

8:48 A lot of people deal with high-homocystein. In a 2011 stroke model, pre-treatment increased survival rates after ischemic events in old rats and modulated again, the caspase 3 activity, suggesting brain preconditioning against injury, pretty cool. Then 2020 diabetic memory test, Penelon improved learning in diabetic rats and normalized NMDA receptor gene expression in the hippocampus, which preserved memory machinery for those rats. It's pretty interesting. Now, what do we know about Alzheimer's?

9:18 Basically type 3 diabetes. What do know know people that are in their early stages? of dementia, Alzheimer's, neurodegenerative disease. A lot of times it's this metabolic effect that's really like type three diabetes. Depending on obviously in these diabetic rats, if you're a rat like myself, it might be something that you could use to help stem the tide of it. Should you so choose? And then other models has demonstrated antihypoxic properties, improve survival under low oxygen and reduce lipid proxidation and tissues across multiple studies.

9:48 So hey, what's the best peptide for lowering cholesterol? Well, it wouldn't be Penelon, but it would be in the conversation because there's data behind it. Looking at some of the human data to which we do have a little bit. Like I said, there was a 32 patient trial. They were aged 41 to 83 with cognitive impairment and they showed enhanced central nervous system activity and slowed biological aging markers. It had significant neuroprotective anabolic effects with no genetic damage. Also, There was traumatic brain injury study. they took 72 TBI patients.

10:20 And after their concussion, they used Panion and they experienced improved memory, shorter headache durations, better emotional stability, and increased alpha wave activity on brain scans, which is pretty cool. And for someone like me that comes from the contact sports slash football world, that's always something that I'm looking at just because I know people in that world and obviously have a lot of experience in it. But looking at stress and sleep studies, there was an eight week study in adults with circadian rhythm disorders and they found that Panion significantly

10:50 improved sleep quality scores and restored normal circadian markers and then high stress professionals reported better sleep, reduced anxiety and improved cognitive performance. I do want to copy off this and say, look, if you're not hormonally optimized, If you really trashing your body with alcohol and things of that nature, Is Penelon going to have this like dramatic, dramatic effect? No. However, if you're more or less like 70 or 80% doing things right, but you still seem to suffer from some of these things, Penilon can be a godsend in a lot of cases. And again, most women's studies have been pretty small.

11:22 Now looking at injection dosing, it's kind of all over the place. And so what I did is I kinda scraped the internet to see like, okay, like what are other people saying? And then what have I experimented with on myself and what do I recommend for people? What you'll usually see if you go across the Internet is this 100 to 300 micrograms per day range and people do that as a sub-q injection for 10 to 20 days. I think you could do it as an IM injection too if wanted to feel the effects more rapidly. than having them kind of build up over the time that you're using it and this low daily dose is sufficient for a lot of people and then typically you would

11:57 do that for two to four weeks or 10 to 20 days. Now I on the other hand I really like two milligram per day and I would that probably in the neighborhood of like 10 to 60 days. I would say 10 if it's more of an acute issue. However, if there is lots of issues with the HPA, lots have issues, with cortisol, and lots issues of the stressful thing, I think you could use this for up to sixty days, that's what I've done in the past. And it worked really well. Now what's interesting is when I did this, doing the higher dose, it did kind of have a little bit of a restlessness effect because I took it at night.

12:31 You could take this at the night or in morning. It doesn't seem to keep you up for most people, but also it doesn' seem make you sleepy if you're taking it in But for me, like a lot of times I would switch it to the morning. Cause I noticed if I took it at night, kind of had a higher heart rate, kinda was a little bit more restless. And so I just switched it into the mornings, but you could do either one. But typically I wouldn't do much more than that. So two milligrams a day for 60 days is usually plenty. Then if you wanted to do a micro dose of eight to 12 weeks, starting at 200 micrograms daily, titrate up to around half a milligram. You would get like, a total of 20 milligrams per cycle.

13:02 I think any time you're getting somewhere in the neighborhood of, you know, call it 22, 100 milligrams on the course of a cycle, you're probably going to be in a good spot. Although I wouldn't do that more than once or twice per year. I think the effects seem to live longer than that. Meaning if I use it for two months, it seems like the affects carry on for months after that and maybe that's placebo. Maybe that me again, I'm just with all these, we're kind of giving our best guests.

13:32 We don't have a ton of data on them. But I think if you were going to do it, you know, if look at a total load throughout the year, I would probably say don't do more than 100 milligrams throughout a course of a year. You know if we get them to like the 120 range, that's fine. If you're doing 2 milligrams a day for 60 days, obviously that would be 120 milligrams, so that is fine, probably no more then that. But 2 mg a days for 30 days is a fine cycle and I've done that plenty of times before. Again, you have two milligrams per day for 30 to 60 days.

14:03 Generally, 0.1 to 0,5 milligrams a day, for two to four weeks, would be the conservative, and then you could titrate up. And again, I would take one to three month breaks between the cycles and just do a sub-Q injection into the belly. We look at side effects. With sleep, transient sleep pattern changes, vivid dreams, mild insomnia. If dose too late, like I said, that's something that I definitely experience. Effects are usually temporary and resolve with adjustment. Again, if that happens, you can switch to the morning or you could just take down the dose a little bit or just wait a week or two and it probably would

14:35 go away. There could be mild anxiety or irritability in a minority of users. And then in rare cases you get dizziness, brief fatigue or lethargy. Sometimes, not all the time, but sometimes people with bioregulars might get some injection site reactions. Think of anything, you don't really get reactions as much as sometimes the bi oregulator stink a little bit. Not all of them. Penelon really didn't do that for me, for some people do. And again, we don t have a lot of long term safety data, based on the mechanisms, I think it would be fine. Looking at some common stacks, this is one that I would probably use with another peptide.

15:10 So a really common stack, one of the more very common anti-aging stacks is pairing with epitalon. Epitalin obviously normalizes circadian rhythm and boosts melatonin production. And together with Penelon, it provides full neuroendocrine support. Epitalin addresses some of the hormonal and circadian aspects, and Penilon does cellular and neural aspects. And this would be used for restorative sleep, anti-aging and brain rejuvenation. We have cerebroliacin. I think if you're using cerebroliacine, you could throw in Penilan on top of that to just get a little bit more bang for your buck.

15:41 But obviously, cereboroliocin is a mixture of neurotrophic peptides, providing growth factor for neuron repair and synaptic function. Penelon reduces neuronal stress and apoptosis and it creates powerful brain regeneration protocol for TBI recovery, Alzheimer's and neurodegenerative conditions. I think if you're running cerebral isin, there is absolutely no downside to throwing penelone or maybe even throwing epitalon and penion with it. your schedule might be a little bit different. So you might not take the same every day, meaning that you like, you'd use Cerebralis and maybe for like 20 or 30 days, maybe use Penelon or Repitalon

16:13 for the course of 10, 20, 30, days. Whatever it is. Just be conscious of how you structure that. And then if you wanted to, these would be much more mild, but you could use CMACS and Selenq. CMAS boosts BDNF for focus and mental energy. Selanq provides angiolytic effects and Penilon supports underlying neuron health. So it's synergistic for comprehensive cognitive enhancement and stress resilience when you stack those together. So just to sum up, Penelon can enhance cognitive function, aid recovery from neural stress and possibly slow certain aging processes. Again, we see improvements in memory and attention and clinical trials and significant neuro protection and animal models provide scientific basis for

16:48 its use. And so far, remarkable lack of toxicity. We really don't see any downside to these. I can't say for certain, obviously, because it's really hard to say anything for certain, but definitely something that in the future, I think I hope more people will become exposed to. And again, those are the studies. If you want to screenshot the stories that I pulled this information from, and that is it for the slides. And that is my comprehensive overview of Penelon. So again, it's not one that you really need to harp on too much.

17:19 And again there's, not as much data as we have on some of the other peptides, but one I still love nonetheless. If you find the oral version, I think the world version is totally fine to do, But I really liked the injectable version. I've used it in periods of my life where I tend to be a little bit more stressed. When I had periods like extended travel for work or things where know my more circadian rhythm. and my internal clock is going to be off. It's a really good one to have there. I think in some cases where you're traveling, maybe you are in a hotel or you were exposed to not your normal environment that you used to sleeping with,

17:52 that maybe create kind of like your little cave that your sleep in really well at night. At home, it could be advantageous in those situations. And I, think again, to the point of stacking, It stacks really with Apatalon, stacks well with Cerulean and there's ton of other ones I could get into, but I those would be the main ones. One thing I'm kind of working on in my brain right now is mapping out kind-of like a bioregulator, an injectable bi-irregular protocol. There's a little bit of data out there from some different Russian stuff, but it's, you know, it can be challenging to say like,

18:22 okay, we have these 20 biiregulators, how do we use them? And if we just want to use it for longevity, Me know if you guys would be interested in something like that. But let me know your feedback and thoughts on this one. Neon's great. Pretty affordable, pretty cheap, and pretty easy to find. So I highly recommend if any of those things apply to you, that you check it out. And even if they don't, it would a really good one, I think, for someone that has any sort of concern around cognitive decline dementia.

18:55 I wouldn't use it in isolation, but I would pair it with some of the other things to really help stem the tide of neurodegeneration maybe even slightly reverse it a little bit if that's already there, but then obviously, too, if you just want to be on guard against that or you've had concussions in the past or something like that. Like myself, I think it's a great one to try. So love you guys, thank you so much. And closing, just wanna let you know, and I know it might get old if you listen to my content, but I truly, truly cannot thank guys enough for supporting me. It's dream come true for me to get to do this. Hopefully that comes through in the material, But I want you to know that in whatever shape, form, or fashion you support me,

19:30 whether that's being on the email list, using my code at places, joining the group, even just sharing this with your friends and family and telling them about the amazing things that peptides do. That is why we're here to lift up the planet, make the world a better place. And I would not be able to do that and have this platform without you guys. So thank you so much. Looking forward to see you in the next one. Peace.