Enclomiphene vs TRT Which Is Right for You

0:09 Hey everybody, this is Hunter Williams. I hope you were doing amazing wherever you are out in the world. Today is probably a long overdue video. The name of this one is Enchlomophen versus TRT. This was actually something that I get questions about all the time. I think you know when you look at topics, I kind of tell now like what topics are like rising or falling in human consciousness. This seems to be one that is rising. So I at least 10 to 20 or 30,000 people that are thinking the same thing in their head.

0:46 So this actually came in light of a recent client that I was working with, and he actually suggested this is a good video. And I said, hey, you're actually right. But today, what I'm going to be doing is looking at enclomophene versus TRT. Now, if you are looking for a video that's like, Hey, this isn't clomaphene. This is why it's good. That's why its bad. not the one, unfortunately. What I'm going to do today, I will explain what they do, how they work, but what I am really going talk about, so if you don't want to hear my personal bias, you can probably turn this off now, what i'm gonna talk is why Enchlomophen or really any of these other agents, whether it's HCG,

1:23 Clomophene itself, Enclomaphene and Clomorphene are different, aromatase inhibitors, Uh, whatever it is that enhances your own natural testosterone production, I'm going to discuss why they cannot compete with testosterone itself. So yes, it's biased. I want to go ahead and disclose that to you. This is what it was going be about. Um, but hopefully this gives you a more informed decision. If you are looking at this because chances are you to follow me and these topics are relevant to. Or do you search this term out? And, uh, did a good enough job of getting your attention amongst all the other videos out there.

1:57 Uh, to sit down and listen to me talk for 20 or 30 minutes or however long this video ends up being about the differences and why and clomophene really can't compete with testosterone for the longterm, really in the short term too, but for long term. So, um, that's what we're going to talk about today. And I think as more and more people become aware, they have a testosterone deficiency. More and people are going get suckered into taking in clomorphine instead of testosterone. And ultimately, we'll get into this is because we're like, well, my testosterone levels are higher now, so I'm good, right? And the answer is no. So we will talk about all that.

2:27 But before I share my screen and go through into the meat and potatoes, as always, check out my new book. It's called Testosterone, the God Molecule. I got it here on my bookshelf behind me. You can head over to Amazon. The audiobook should be ready pretty soon. I'm not going to be recording in my own voice, but I had great reviews on that so far. So thank you to all the, you know, people out there that have read it and give me great. Reviews, check out the peptide cheat sheet. That will be in the link down in description. I will sign you up for my email list. And then lastly, head over to fully optimized health, where if you want an inside look to, be able to message me or talk to any of the other amazing people that,

3:02 uh, there's like over 470 people in that group. Now, um, There's a lot of people who are as smart, if not smarter than me in there. It's an amazing community and I would highly recommend that you join that and come join the party inside there. So without further ado, I'm going to share my screen and let's learn today about why and clomiphene can't compete with testosterone itself. All right, I am Hunter Williams, and today's video is about enclomaphene versus TRT. So let's jump into it. What is the difference? Mechanism of action. Let's look at the mechanism of actions first.

3:32 It's going to be very simple, but I just want to give you a tool, like a toolset for understanding the differences. Enclomophene basically works through a variety of things, basically to stimulate the body's own production of testosterone by increasing luteinizing hormone, otherwise known as LH, and follicle stimulating hormone, otherwise known as FSH from the pituitary gland. Testosterone itself provides exogenous external testosterone directly to the body, bypassing the bodies natural production pathways. What does this do to fertility?

4:03 So basically colomophene helps maintain or even improve fertility by promoting endogenous production or testosterone production and supporting sperm production. Whereas TRT can suppress natural, uh, production, It often reduces sperm potentially impacting fertility. What's the difference between consistency of levels? This is where this video is going to really hit home is the basically in clomophene can lead to variable testosterone levels depending on individual visual responsiveness and natural production capacity. And then TRT offers consistent stable testosterone level as dosage and administration can be precisely controlled.

4:38 I would even say surgically precisely control. And then administration and frequency and clomiphene typically taken as an oral pill with dosing that may vary based on your response. And TRT administered the best way through injections. You can get gels or patches or even oral now, but they don't work as well. But it's, you know, obviously at a very precise dosing schedule and application timeline. So that's the main differences in case you didn't know. Now let's look at some reasons as to why and clomophene cannot compete with testosterone itself.

5:16 First one is limited stimulation capacity. So most of the drugs, like in Clomaphene, and I kind of lumping all the other serums, AIs and HDG into this, but in clomophene just cause that's the most popular one by the internet marketing, venture capital, private equity people that are pushing these things. But basically most them work by encouraging the body to produce more of its own testosterone through hormonal signaling. However, the bodies natural testosterone production is almost always constrained by genetics, age and existing health conditions.

5:46 So this means the increase in testosterone from all the medications like in clomophene will likely fall short of the levels that can be achieved with exogenous testosterone, especially in men with significantly low baseline levels, which now is more often the rule rather than the exception. Moving along, we have this dependence on the pituitary testicular axis. So what does that mean? So drugs like Clomid or Enclomophene or HCG rely on a functioning pitutary, testicular axis to work effectively. In some men, particularly older adults or those with primary hypogonadism, which is testricular dysfunction, this axis may not respond adequately,

6:20 making these medications less effective. Direct testosterone therapy bypasses this pathway. directly supplying the hormone without needing pituitary or testicular function. So if you've followed me or read my book, you know that I got hit in the head a lot because I was a division one college football player. I played linebacker. And when you do that for 17 years of your life, your pitutary gland doesn't work as well anymore. No matter how much enclomaphene I took, it wasn't really going to get me to the levels of testosterone, at least from a symptom resolution standpoint that

6:55 I needed because of the impairment of my pituitary testicular axis because I've been hit in the head a lot. And that's not something that is actually that rare. Many football players deal with that. many athletes deal that many hockey, soccer, rugby, anyone that even remotely gets hit the hit or impacted. And then also too, we have military personnel, first responders that often deal with things like this that impute impaired their pituitary access. So much more common than you would think, you know, it's not just people that got like in a severe traumatic accident or anything like that.

7:28 Um, then we have inconsistent and variable responses. So individuals respond to drugs like serums or in clomophene or HTC, uh, very widely. so some men may see a modest increase in testosterone with in Clomaphene. Others may not see any increase or temporary boost. And in contrast, testosterone itself offers a predictable, consistent increase and testosterone levels. Pretty much. I mean, there's, I'm sure some exceptions, but pretty much without exception. Um. Let's keep going. So we have slower onset effects.

7:58 With testosterone therapy, men typically will experience immediate and noticeable improvements in testosterone levels, which is what they're trying to get. They're have weeks or months before you really even feel anything different that's aside from placebo. And again, I say all of this. I should have prefaced this I have done in clomophene before I ever started testosterone. So I've been there, done that.

8:31 In more ways than one speaking to myself or people like me that were in the same place as me. We also have lower peak testosterone levels. So, enclomaphene and the like can usually raise testosterone to the upper end of the physiological range at best, which is also often falling short of what we would now call superphysiologic doses that men desire or require for symptom relief. In reality, the super physiological dose oftentimes is just what men would have had 50 to 100 years ago, but now because everyone's levels are low, it's considered a super-physical dose.

9:03 However, so including the option to maintain consistently high normal levels, or even slightly above normal, is not possible with encomophene. And I'm going to get into the levels in a second, So kind of hang tight on that. Then we also have the indirect effect on testosterone metabolites. So when testosterone is supplemented directly, its metabolite, which are even more important than testosterone itself, Which are DHT and estradiol amongst others, are also directly influenced contributing to the complete spectrum of male hormonal health or female hormona health.

9:34 Pharmaceuticals that indirectly stimulate testosterone production can lead to very inconsistent or very suboptimal levels of these metabolites, which may not provide any or all of the same physical, cognitive or sexual benefits that we would get from testosterone itself. Let's look at side effects, because everyone wants to talk about the side-effects of testosterone, but no one seems to care about side effect in clomophene. So aromatase inhibitors, I mean, go look up my video on why you should never take an aromates inhibitor, But let's just look even in just in Clomaphene, so, you know, Chlomid or in Chlamophane may cause visual disturbances and move swings, and obviously aromasase can lower estrogen too much,

10:11 leading to bone density issues. However, when we supplement directly with testosterone, it can often minimize or negate or neutralize any of these side effects as testosterone is something that's produced in everyone's body. Then we have the declining testosterone with age. So as we age, our body's ability to respond to hormonal stimulation decreases, limiting the efficacy of medications that depend on endogenous testosterone production. Testosterone therapy is going to bypass these pathways that or oftentimes not working that great to begin with, which is why men have low testosterone.

10:47 So again, it's just going to bypass that. And then ultimately we have difficulty in sustaining long-term effects. Some of these drugs, like in Clomophene, may only be effective in the short term with testosterone levels potentially dropping back down once treatment stops. However, testosterone therapy on the other hand is designed to maintain consistent testosterone levels over the long-term safely and effectively as it directly provides the body with hormone that it needs rather than trying to continually stimulate the bodies production. And ultimately, in my opinion, I don't have any studies to back this up just from practical experience.

11:18 Ultimately, the bodys kind of kind to normalize and kind like go back to where it was, happens a little bit with testosterone too. But within clomophene, you're gonna have diminishing returns over time and so for the Really, I think most people know that it's just to bridge the gap to get them to testosterone, but why would you bridge a gap when you can go to the destination? Just teleport there. Now, the next part is called, butt hunter, my levels are just as high. Why would I ever use testosterone if I can get 900 total testosterone within clomophene?

11:53 You know, that's double what I had before. The average man right now is probably working around with 350 or 400 total testosterone at best naturally. And then they take encomphene and gets it up to 900 and they go get excited, but they don't really notice any difference. Again, That's my experience. and a lot of other people's experience I've heard from, but let's look at why it doesn't really matter that your levels are just as high. So I would even say that like a lotta times, like when I took in Clomophene, I got up to like 880 or 900, and depending on like, when get my blood drawn, my testosterone on just a therapeutic dose is really not that much higher.

12:25 You know, it's probably sitting somewhere around 1,000, so you'd be like well, if my levels were just this high with the Clamophane, what's the difference? Well, let us look why that's very important. Again, that goes back, to the stable hormone level. So with testosterone itself, levels are directly controlled and can be kept stable through tailored dosages and consistent administration, whereas enclomaphene basically relies on your body's own production mechanism. Maybe you don't sleep as good one night, maybe you go off on a diet, or maybe drink a bunch of alcohol or something.

12:55 Enclomaphene is going to work way less than testosterone itself because it's relying on a lot of these mechanisms of the body that should be functioning properly, but they're probably not because of lifestyle or other things. So because this inconsistency, a of times within clomophene, you're going have more mood swings, energy dips, and other variable symptoms as opposed to testosterone. Now, that doesn't mean that you shouldn't live healthy with testosterone or that it is like a free ride to go do whatever you want. But it does mean you have much less susceptibility to that than you would with enclomorphene.

13:25 Um, I think this is probably, if you get one takeaway from this, this the most important thing that like, you could just say this negates why and clomophene would ever be useful in terms of having a therapeutic effect on testosterone symptom, low testosterone, symptom resolution. And that is the effect of DHT and estradiol. So like I said, testosterone turns into DHD and turns in estrdiol in the body. DHT is crucial for libido, confidence and physical performance, while estradiol supports joint health, mood and cognitive function, and also protects our heart.

13:56 So testosterone ensures these metabolites rise in a more controlled, predictable manner. While there's an inclemophiline, the increase in DHTs and estridiol on an anclomophene may be more limited or erratic, potentially leading to a less complete testosterone experience. And ultimately it's why men on enclomaphene will never feel like men testosterone. We also have reduced androgen receptor sensitivity. So when testosterone is administered directly through injections, it activates andogen receptors more robustly and consistently than endogenous production.

14:30 that is stimulated by drugs like enclomaphen. So the stronger activation of androgen receptors can produce much more pronounced physical and mental benefits such as better energy, strength, and focus. And pharmaceutical alternatives like enclomaphene may increase the overall level, but it might not actually stimulate the androgens receptor enough at the cell level with the same potency. Again, this is why even if your levels are the Same or like negligibly different, between and clomophene and testosterone, you will not feel the same and it will be the the practice.

15:03 So yes, on the paper it looks the, but in practice it's vastly different in terms of applicable feeling. We also have the difference, and again hugely important, in free versus total testosterone. So we do not see a rise in the free testosterone typically within clomophene like you do with testosterone therapy itself. Free testosterone is what binds to the androgen receptors and produces the notable effects of high testosterone The result is that while testosterone numbers might look similar, men on pharmaceutical determinants like enclomophene may feel less of benefits because their free testosterone money remains lower.

15:39 So oftentimes, enclomorphene is not boosting free-testosterone levels. Free testosterone is what binds the receptor to give us the effects of testosterone. If you don't have enough free testosterones, it doesn't matter if your total testosterone's 5,000. if you're free to testosterone still 10, you are not going to feel any different. And in my experience too, I would need to double check on this. So I think that there probably is something going on with a clomophene and SHBG to where it's like, maybe like raising SHPG again,

16:14 not scientifically saying this, just theorizing that. There's something on there with like it is not raising free testosterone and maybe it was because it stimulated SH BG or I don't know what, but ultimately and clomophene will never give you really any bump in free testosterone levels. It didn't for me. Whereas testosterone itself is what will ultimately raise free test house levels we also have. This is very important in terms of mood and cognitive benefits is neurotransmitter balance and production. So testosterone impacts a range of other hormones and neurotranmitters affect mood, motivation and overall wellbeing.

16:50 Testosterone directly influences dopamine, which is a key neurotransmitter for motivation and pleasure. And it has a predictable effect on these pathways while drugs like aclomaphene can interfere with estrogen signaling or other hormonal pathways leading to irritability or mood swings. First-hand experience that myself. Um, but this interference can disrupt the overall feel of optimal testosterone levels. So again, you may have the same total 900 total testosterone level, But if I have actual testosterone therapy, it's going to support dopamine production in my brain, which makes me feel better, Which lifts me out of depression.

17:22 Whereas in clomophene actually may cause me to be more irritable depending on whatever is going on. Uh, with my estrogen, again, I'm not going to talk about that in this video, but understand that it does not support balance and production of neurotransmitters the way actual testosterone will, which again levels being the same. That's cool for lab work, But why does it matter if your levels are the but you're not happy and you are excited and resilient and like the energy to get up in the morning. And that's the difference in testosterone. I know that because one of the symptoms I had pre any of this was severe depression.

17:53 That's because my testosterone was so low. Because when your testosterone is low, your brain can't make any dopamine. So when you're brain get make dopamine, you get depressed. It's weird how much people focus on like serotonin for resolving depression, a lot of times dopamine... If you raise dopamine a lots of time that going to like... I'm not saying serotone is not important. A lot times you raised dopamine that gonna like do the job. And testosterone can do that. And then lastly, we have the psychological and physical sensations of testosterone. So for anyone that has been there, they know that testosterone itself obviously is going to provide a physical boost to increase vitality,

18:30 energy, and strength. This effect is due to the consistent high normal testosterone levels that Testosterone can maintain for us. Uh, whereas in clomophene is going to be fluctuating. So it's going up and down. It's still like our muscle building, our fat loss. If we're not stabilizing levels or they're dependent on our endogenous, like production pathways. Well, guess what? Muscle building fat, loss, all those things are going fluctuate as well. Um, we also have the variable LH and FSH response. And, uh, it was actually something that my client was dealing with. Pharmaceutical options like in Clomaphene increase testosterone by stimulating L H and S H.

19:03 which can lead to testicular production of testosterone. However, this indirect stimulation is slower and less consistent. So additionally, some men experience side effects from elevated LH and FSH such as testicular discomfort or mood swings. their body is like producing a ton of LH and FSH, but it's not converting into testosterone for whatever reason. It could be cortisol levels, it could, you know, like stress levels could like a metabolic thing. But oftentimes what happens is, okay, your L H and FSH are through the roof.

19:36 So if we're going to take in Clomaphene, is it going do anything to testosterone production? Maybe, but maybe it's not because like raising those to a point is going to have dimension returns. It's just not going necessarily take those and synthesize more testosterone out of them. Is just going boost levels higher than they already are. Um, so for instance, like I didn't have high LH and FSH levels because my pituitary is impaired, in order to have higher testosterone levels, but the body, like in the testes or whatever is going on, has pathways that are impaired that it's not gonna do it.

20:08 And again, how do we solve this? We don't solve it with anclomophen, we solved it testosterone. Then ultimately it just comes down to the consistency and symptom relief. Testosterone is prescribed to a dose that consistently keeps symptoms of low testosterone at bay. However, the symptom or relief, if there's any from an clomophene, maybe inconsistent, Um, which can vary over time. So men often find that testosterone provides a more steady remunerable relief from symptoms compared to pharmacological alternatives. Um. I think that pretty much makes the case.

20:39 Maybe some of this is a little redundant, but I. People learn the best from immersion. And so if you are on the cusp, so to speak, you're out there like trying to figure out how any of the stuff works. That's why, and so it's Y and clomophene or anything can't replace testosterone. It's kind of like, this is not the best example, but it's kinda like if you could take a vitamin D booster in the body or vitamin d itself, what would you rather take? What's like? If you can take pill with vitamin, D or a pill, the vitamin B booster, I would probably like to take vitamin.

21:09 because it makes my levels higher and it make me feel good. It makes me have a better mood. Makes my immune system function better. Maybe the booster works, but vitamin D itself is better, I'm just taking what my body already has and what I need more of. So I kind of view testosterone the same. I know it's not like the best pound for pound analogy, so to speak. But anyway, that's it for the slides. And that is why enclomiphene just cannot compete with TRT. So I understand this was misbiased. And if you get good results with enclomorphene, I'm not telling you to stop.

21:40 I don't even think I would necessarily tell someone to maybe not do enclromophene before testosterone or insert HCG or whatever for that. Definitely not a neuromatase inhibitor, but whatever. Um, just to have the experience, you know, I'm glad I did it. I think I probably used it for six months before I ever started testosterone and I guess it's better than nothing. Like my life within Clomophene was better then with no testosterone. but it pales in comparison to what testosterone did for me. And I would say ultimately the biggest difference lies in the mental side of things.

22:15 Um, I even noticed like probably a little bit of physique enhancement from enclomophene relative to coming to like off of like 100 total testosterone levels to having like 880 from the enclomorphene. I noticed I did build muscle a little bit easier, but man, it got way better once I started testosterone. So if the answer is nothing, I think in Clomophene is better. And I would even say just for your own sake, so you have your data around it, try in clomaphene and see. You're going to see maybe it's better than nothing.

22:47 But I that, too, is kind of the trap, because it was like, well, in clemophane was better nothing so I don't need to start testosterone, and you never really get to feel what it feels like with testosterone And if there's one thing I do, I would just wish I could give a man or a woman like two days in life of a person with optimized testosterone levels. And so much would change. So much of like, not only their physical health, the physical help would be like 15%, but everything would. Mostly like their mental and emotional health. so much would change for a person if they could just be in a body with optimized testosterone levels for like two or three days.

23:20 Like so many of their belief paradigms around how the world works and what they think they're capable of and they do with their life would immediately change. And I'll close with this. The world The matrix is not predicated on men and women having optimized testosterone levels. I'll leave it at that. So this is this video, hopefully stays out there, but, um, yeah, there is a good difference between what you will feel like on and clomophene and what will you feel on testosterone. And I'm not telling you to do one or the other, even trying clomorphene maybe before testosterone to see how you'll feel.

23:54 That's probably what your doctor will tell you do. Um, depending on your age, you know, if you're probably under the age of 45, that's what they're going to tell me to. But yeah, that's pretty much it. And I'll just close out with thank you guys so much. Again, this content gets better the more and more people that give me feedback and the comments and questions and everything I get. Always remember there's a link down in the description of the video where you can always submit a question or video topic. to have me answer in a Q&A video or potentially a video itself. So again, thank you guys so much. I love all of you, guys.

24:24 Thank you for the overwhelming support. You know, I am blessed and excited every day to get to do what it is.