LDN For Longevity The Life Changing Benefits Of Low Dose Naltrexone

0:09 Hey everybody, this is Hunter Williams. I hope you were doing amazing wherever you are out in the world. Today's video is going to be using LDN, otherwise known as low dose naltrexone for longevity. So to give you a brief bit of a backstory on this, Having coached people for a few years now, I would see a lot of people that were really into the longevity, anti-aging space, because those were most of my clients. And they would come to me and a lotta times their doctor would have them on peptides or different things.

0:39 Then I'd see this thing in there that I didn't know anything about, and it was called LDN, just known as low-dose naltrexone. I asked them, what's this in here for? They'd say, they don't really know, but my doctor gave it to them. Okay, so that's interesting. The cool thing about coaching people and doing a YouTube channel like this and stuff is I hear amazing feedback from people. So it kind of allows me to synthesize all these different cases and circumstances and everything that people are in and make connections and be able to teach you guys better information. Anyway, it's been on my radar for a couple of years, but I never thought that it would be something that I need or look into or whatever.

1:14 But I noticed in the last six months, there started to be more chatter around LDN, especially the relates to anti-aging and longevity. And a lot of times it get grouped in with rapamycin. Anyway, it came to my attention lately through our amazing community called Fully Optimized Health, which you should go sign up for, link down in description. but we had a member in there or a couple of members that were talking about this and using it and giving us feedback. And what they were saying is that it was basically transforming their peptide use to where typically like you will build up a slight tolerance to peptides

1:50 over time. It was making it seem like they had taken the peptid for the first time, it kind of like re-energizing the peptide. Basically what it's doing is kind resetting the receptors to the Peptide, thus allowing the Pepide to work better. So I was like, huh, that's really, really interesting. So I went ahead and ordered some myself and have been testing on myself. So i'm going to talk a little bit about that on the in the video. But basically, the more and more I read about naltrexone and get feedback from people on it, I've kind of come to the conclusion that it might be one of

2:20 the most powerful anti aging slash longevity compounds that we have access to now. even up there with Metformin. So that's yet to be determined, but what I wanted to do today was explain everything about LDN and how it works and what it would look like in the context of longevity protocol. Again, I'm experimenting on this one myself. I've been doing it for two weeks now and I feel pretty amazing using this. And I walk through my experience as well. But it's really cool.

2:51 we're really just scratching the surface of this. Uh, and what I wanted to do today, uh, as I'm getting started on this is just lay out everything about LDN. Um, so you can kind of understand it better. And I think anytime we hear a pharmaceutical, I know I am pretty skeptical myself. But once I started reading in this, that's like, Oh, okay. This is definitely something I can use and potentially use for life. So we'll see how that goes. In today's video, going to walk through all of that and, potentially give us insight into how this could be used as part of our anti-aging slash longevity

3:22 stack to minimize inflammation, obviously enhance our health and everything overall. And as a bonus, we're going to look into how this would play into peptide use and then also hormone replacement therapy use. So we are going go through that as well. Before I jump into the slides and share my screen, remember, if you would like the peptide cheat sheet, the link for that will always be in the description of this video. I already mentioned fully optimized health. And then finally, a thing that I've been doing that seems to help with the videos is if, you guys would, like my slides, which I create and prepare through all my research and everything for these videos, it takes me a good amount of time to do so.

3:56 If you would like access to those, to where you can download them without having to submit your email or anything like that. And if you're on my email list, I'll also send them out to the email lists. But if would that, like this video. the PDF of the slides and everything. So it takes me extra work to do that, to like make a link and do all that stuff for you guys. But if I get enough feedback, this is a good video. It's the kind of content you want. I definitely would do. And obviously too, the more people that like it, The more it pushes it out in the algorithm and helps other like-minded people find this content so they

4:30 can optimize them of their best life. That is it. Let's get into the sides. Today we're going to learn about low dose Naltrexone. All right. I am Hunter Williams, and this is low dose naltrexone for longevity. So let's jump into it and get going. What is naltrexon in general, then what is LDN? So low-dose naldrexxone is the use of a drug known as nalltrexxon at doses significantly lower, typically 1.5 to 4.50 milligrams than those used for treating

5:01 opioid addiction. Basically, at these doses, it has been shown to modulate the immune system, reduce inflammation, and potentially provide benefits in various chronic conditions that we're going to walk through today. So basically, LDN is an opioid blocker. LDM. Now I said that the low dose would be 1.5 to 4. 5 milligrams. Typically for someone with addiction, this is going to be used at 50 milligrams a day. So if someone is addicted to pain pills, alcohol, opiates, any of those things, uh, This helps them break that addiction.

5:34 Um, but if you're using it in a very, very low does, it's going have much more of these uh, longevity side effect or longevity benefits that we're going to talk about. So basically LDN temporarily blocks opioid receptors leading to a rebound increase in endorphin and enkephalin production. This is effective, um, is believed to modulate the immune system, reducing inflammation and promote tissue repair. Kind of think about exercise is that when we exercise, it stresses the body. Uh, and then after that, we get an end orphan release. It's kind of the same thing when he blocked the opioid receptor, And then that drug gets metabolized and move through the body.

6:09 It releases a flood of endorphins, which helps us feel better. And it also too creates a cascade of all the positive benefits of anti-inflammatory benefits and immune system boosting benefits, much like exercise or other things that release endorfins. So it also modulates, like I said, the immune system. So, it enhances the activity of regulatory T cells, which help maintain immune tolerance. And this can be particularly beneficial in autoimmune conditions where the system attacks the body's own issues, or excuse me, own tissues, on issues too. But basically think about it as an immune-system modulator.

6:44 In the case of autoimmune disease, that is basically where the immune system is in an overactive overdrive response and it begins actually attacking the body itself. Conversely, we could have a suppressed immune in which the system does not function at all and we're susceptible to disease or bacteria, fungi, whatever you want to call it. And in both cases, the body is going to be out of whack. So basically this is a modulator, meaning that whether the immune system is suppressed or whether it's overactive, it is gonna help bring it back into balance. It also has pretty good anti-inflammatory effects, so it has been shown to reduce the production of pro- inflammatory cytokines such as IL-6 and TNF-alpha.

7:23 which are implicated in aging and chronic diseases. So it's going to reduce the production of these, which obviously for the long-term is going be good for our body and all the biological systems. Now, obviously this is about longevity. This is not about using it for addiction or anything like that. But if we look at it in longevity, what are these mechanisms going to lead to? So the first one, obviously we know the importance of inflammation and longevity. So chronic inflammation is a key driver of aging and age-related diseases, is what we're all fighting against in this battle.

7:53 By reducing inflammation, LDN may help mitigate the progression of conditions like cardiovascular disease, neurodegenerative disease which I know is a big topic today and metabolic syndrome, which is the biggest topic or obesity which are associated with aging. So by clearing this inflammation from the body, LDN is going to play a massive part in helping stem off the tide of all of these things that we're up against in the modern world. It also has neuroprotective effects. So it may protect against diseases like Alzheimer's and Parkinson's by reducing neuroinflammation and also promoting neuronal survival.

8:31 Also too, I won't go into this as much because you paint a target on your back, but we look at cancer prevention. Some studies suggest that LDN may inhibit the growth of cancer cells by modulating the immune system and reducing inflammation, potentially lowering the risk of age-related cancers. So again, when we look at that in theimmune system, that type of disease and the Immune System, we're bringing the immunity system back into balance to allow the body to heal itself. And obviously too, the big thing is autoimmune disease management, Obviously autoimmune disease is rampant in the population today and has been used to

9:05 manage auto immune diseases such as MS, otherwise known as multiple sclerosis, Crohn's disease, and lupus. So basically by reducing auto-immune activity, LDN helps preserve tissue function and prevent the damage that contributes to aging and chronic illness from autoimmune disease. And then lastly, and this is where I get really excited because, you know, like we can talk about obesity, we talk auto immune, but if you're already really healthy and either that's, more the exception rather than the rule these days, mitochondrial function.

9:35 So mitochondria dysfunction is obviously a hallmark of aging. I just made a video recently about sloop and how important that is for mitochondrion function, as a new compound that we're using, but LDN may improve mitochondrial function by reducing oxidative stress and inflammation, thereby enhancing cellular energy production and reducing the effects of aging. So that's where I get really excited. And I think if I look at even just my few weeks of using it so far, I've noticed a difference in terms of my stamina, my energy,

10:05 and my overall wellbeing, which obviously can all be traced back to the health of the mitochondria. So what I did here is just put together a couple of summaries of research that I found as it relates to some of these areas. I don't have to go too in-depth in these, but again, if it gets 500 likes, I'll post the slides so you have access to all this. But when we look at neuroprotection, so study in 2014 found that LDN was a novel anti-inflammatory treatment for chronic pain and neurodegenerative diseases.

10:36 So basically that found by modulating microglial activity in the brain, LDM helps prevent or slow the progression of Alzheimer's or Parkinson's. Also, like I mentioned with immune system modulation study in 2018 found that it enhances the regulatory T cell activity and reduces inflammatory cytokines like we talked about, which again is going to help with longevity. Then we look at inflammation reductions. So I studied in 2010, found that LDN effectively reduces inflammation in patients with inflammatory bowel disease, otherwise known as IBS,

11:13 suggesting that it could be useful in managing chronic inflammation and especially things like Crohn's, ulcerative colitis, all those things. We look in mitochondrial function. A more recent study, 2019, it found the LDM improved mitochondria function and reduced oxidative stress in aging animals. So obviously mitochondrial function is crucial for longevity. And it also, by increasing cellular injury production, it reduces damage caused by fruit articles, which were obviously exposed to on a very regular basis

11:45 in the modern world. Finally, I thought this was pretty cool, especially as it relates to anti-aging. So a 2020 study found that LDN had an effect on telomere length, a biomarker for cellular aging. It suggested that LDN might help maintain telomere link, potentially slowing the biological aging process and promoting longevity. So another win for LDM as it relates to telomeres, which I know is definitely kind of on the forefront right now, but also like a big rabbit hole that you could go down in this realm. Obviously, let's look at some side effects because it can't be all good.

12:17 Well, I think in his case, it's a very, very well researched drug. But anytime we talk about blocking receptors in the brain or anything like that, want to be careful. So I haven't noticed any side effects, but common side-effects are vivid dreams, sleep disturbances, or mild GI upset when first starting. I wouldn't say I had the GI offset. But I did have very, very vivid dream, which was actually pretty cool because they weren't nightmares or anything like that. It definitely increased the I guess the realness of my dreams.

12:52 And, you know, they weren't bad or anything like that, but it was cool. Cause I remember my dream and oftentimes I forget my journey. So it's generally well tolerated, um, But it is also not recommended for patients taking, opioid medications as it can block their effects. If that is something you are trying to use, I know people will use that or whatever to deal with pain. Again, just check with your doctor. And obviously too, there's like probably an infinite permutations of combinations of different contraindications.

13:23 So if you are pregnant or breastfeeding, it's not been well studied in those populations, so I'd probably stay away from it. Now, what I wanted to talk about as it relates to all of you guys for what you followed me for, and where this could be pretty cool going forward in the next five to 10 years or so, is the relation between LDN and peptide use. So basically, LDM is doing something to enhance receptor sensitivity, which obviously when we're using peptides, therapeutically can enhance the effects

13:56 of those peptide. So let's look at what this does. Again, LDN temporary blocks the opioid receptors, leading to a rebound effect that increases the production of endorphins. This process not only improves mood and reduces pain, but it also helps reset and enhance a sensitivity of the cell receptor, Which in the case of using peptides can make the body more responsive to various therapeutic agents. Also, when we look at the immune system, so this is where it gets really interesting. So by modulating theimmune system and reducing inflammation, it can improve the effectiveness of our peptides.

14:28 Peptides like BPC, TB 500, and thymacin alpha 1 work partly by influencing immune responses and promoting healing. LDN's ability to reduce systemic inflammation and modulate immune activity can not only enhance our receptor sensitivity to these peptides, but it can enhance the effects of the peptide, making the body more receptive to their benefits. So it's almost like turbocharging your peptid, so you don't have to use as high of a dose, you may not have use them as frequently,

14:59 and you're gonna get more of benefit from them, which is pretty cool. Now, if we look at these synergy a little bit deeper, when we are influencing receptor sensitivity, it can extend beyond the opioid receptors to other type of receptors. So for example, peptides that target G protein coupled receptors or GPCRs or cytokine receptors may work more efficiently when receptors sensitivity is optimized. And again, when we look at using peptides, because peptide are in not all cases endogenous to the body, when you introduce them to body the has a mild

15:34 small immune response. And over time the build up a defense against that peptid making it less effective for the desired benefits we use. But as I will show you, even in my own experience, the LDN is doing something to enhance the peptde and kind of mitigate and modulate this immune response that we're having to it. So obviously this can lead to improved outcomes and healing, immune function, and overall wellness. Again, when we look at peptide therapy, incorporating LDM may help achieve more profound and sustained effects.

16:07 By enhancing receptor sensitivity, it could potentially lower the effective dose required for peptides Reduce the risk of tolerance and improve the overall response, which I think is pretty cool because the drawback of peptides is always cycle on for 8 to 12 weeks, cycle off for eight to twelve weeks. And then you kind of go from there, Which is cool. I mean, we know we got to do it, but what if we could use this to not only get more gas mileage out of our peptides, but also not have to worry about this cycling and potentially use something like a very small dose of a GLP-1 peptide without having to come off, which I know it sounds like,

16:40 oh, you want to be on a drug for the rest of your life. But if we look at the profound anti-aging benefits of something that, how can we use that and use it in a way that sustains us and makes us healthier, live longer, and live stronger for long term? Which I think is pretty cool. with LDN. So lastly, I wanted to talk about as it relates to hormone replacement therapy. This is something that is yet to be something I can really say one way or the other, but I think it is very important to look at.

17:14 Let's take this idea of receptor sensitivity and look in our hormones. Hormone replacement theory relies on the body's receptors being responsive to hormones like testosterone, estrogen, and thyroid. So over time, due to factors like chronic inflammation, receptor sensitivity can diminish, leading to reduced effectiveness of these hormones in the body. So LDN's ability to modulate the immune system and reduce inflammation can help reset these receptors, improving their sensitivity and responsiveness to the exogenous hormones. And so again, by increasing receptor-sensitivity, LDM is going to allow us to get the same increase in gas mileage out of our hormones,

17:54 namely testosterone, estrogen, progesterone for women, and thyroid, then we would. So instead of normalizing to the effects of these, we're enhancing the effect over time. One of the challenges in long-term hormone replacement therapy is development of resistance where the body's receptors become less responsive to therapy. So by modulating the response to inflammation and stress, it can help mitigate this resistance, ensuring the effectiveness of therapy over time. and it also can work synergistically. So when you pair LDN with hormones, it can actually be beneficial for individuals with autoimmune disease who probably have suppressed hormones anyway,

18:32 or chronic inflammation, where even in the presence of hormones that person can still have poor cellular health. By improving the receptor sensitivity to the hormones it could help restore hormonal balance more effectively and more rapidly than just the presences of the hormone itself. And also to, uh, you know, I'm not so big on like lowering the doses of hormones as much as possible. I more about optimizing the use of hormone for optimal function with the body. But obviously if we are trying to do that in the healthiest way, it's probably the lowest effective dose, right?

19:05 It's not, You don't want to take a whole gram of testosterone a week for life because there's probably going to be some unintended negative consequences from that. So by potentially helping with receptor sensitivity, we might be able to use less of a dose to get the same effect that we're doing, which I think at the end of the day is good for everybody. It's less money. you know, exogenous things we have to do to the body. And I'm all for hormone therapy. I am the biggest proponent of it out there, but at the same time, can we use this to potentially get more gas mileage?

19:37 So when we look at specific ones, so if you look testosterone replacement therapy, it can lead to better muscle growth, fat loss, and libido improvements in men on testosterone, again, for the the dose or at a smaller dose, which is pretty cool. Then we looked at thyroid hormone, therapy which I personally use desiccated thyroid. It may improve the effectiveness of desiccated thyroid, especially in individuals with Hashimoto's or other autoimmune thyroid conditions. And then lastly, if we would look at estrogen and progesterone, LDN can improve receptor sensitivity to these as well, which help reduce the symptoms of

20:12 menopause or hormonal imbalances. So pretty cool as it relates. This is yet to be something that I can really like comment on. All I could really say like this far into it is that I feel really, really good. I felt pretty good all the time anyway, but I fell happy, healthy, whole, complete, mentally, physically, spiritually, emotionally optimized. And I think probably what's happening is that all of the biohacking stuff that I do is just getting enhanced that much more. So we will see how it goes. Lastly, I put the dosing protocol.

20:43 This is what I am going to be adhering to. right now. So these tablets I have come in 4.5 milligram tablets and I cut those up into four. It's basically one milligram, it's 1.125 milligrams, but basically 1 milligram. What you would do is weeks one to two start with one quarter of a tablet, and then weeks three to four, you had increased that to half a tablet. Weeks five to six, we increased to three quarters of the tablet and for up to three to six months, you could take the full tablet depending on how you

21:15 respond to the lower doses. So the best thing to do is take this at night and this obviously aligns with the body's natural endorphin cycle. And then you just kind of have to monitor. Depending on where I get in that stair stepper, I might not even go up a full table per day. We'll see where they go. Obviously I can attest to The Vivid Dreams, which is actually pretty cool, in one sense. To me, it signals that I'm sleeping well. But Yeah. I would say like overall for me, I can tell that is enhancing my peptide use.

21:47 So I've been on a very low dose of retrutide probably going on like close to 12 weeks now, cause I'm experimenting with like a Very, very little micro dose over an extended period of time. Um, that seems to be going well, but I will say in the last two weeks, So at that small dose of like, you know, one to one and a half milligrams per week, it seems to be like the first time that I ever took a GLP-1, which is pretty cool. So it definitely seems peptide use for the body to like the first time you ever use a peptides, which is really cool.

22:18 I think the whole thing with my testosterone, I'll kind of see where that goes. Again, feel really good, but I wouldn't say that I necessarily noticed like a super enhanced effect from my Testosterone. Granted I'm just doing a therapeutic dose, you know, 200 milligrams a week. So anyway, that is yet to be seen, but I can say so far so good. Obviously this is something that's ongoing. I will be talking about probably in the future, depending on where my protocol goes. But yeah, so that it for the slides.

22:48 And that IS the context of Neltrexone as it relates to longevity. So hopefully that was helpful and informative, you guys. Like I said, this was something ongoing for me. Other really, really smart people I've talked to, this seems to be something that is an absolute game changer for the long term. And I think for someone that's doing all of the cutting edge peptide and hormone protocols like Jay Campbell and I talk about, this could be a game changer. So we'll see where it goes. Uh, so far so good.

23:19 Um, and I think the big question that I will probably make updates with is, is this something that is always there like a metformin or like your hormone therapy or your growth hormone? Or is it something you use a couple of times throughout the year to kind of put the body back in a state where, um, you can get more bang for your buck from peptides and hormones and all that good stuff. You know, a lot of people have talked about cycling on and off peptides and cycling off hormones, which is great. But if LDN could be used in the same way that cycling would while it allows us to maintain using those things, but then allowing us have an enhanced response

23:55 to it, I think it'd be really cool. So hopefully that was helpful to you guys. I would love to hear your feedback via the comments and everything below. And I don't forget if you would like access to the slides with the protocol, the information, everything like that to have as a study guide that you can print out or keep on your computer or what have you. If this video gets 500 likes, so I'll make sure to create a little upload link where you download that in the comment. Appreciate you, guys, much love and I will talk to in next one. Peace.