Mitochondria Overload The Hidden Dangers Of Your Favorite Peptides

0:10 Hey everybody, this is Hunter Williams. I hope you were doing amazing wherever you are at in the world. Today's video is going to be about mitochondria overspin and what to do about it. So that sounds like a mouthful. Let me even just simplify before we get into the meat and potatoes of this video. What is So we'll go through this in greater detail, but just to give you like a high level summary. Well, first let me say this. Alex Kickle is the smartest person that I know, way smarter than me when it comes to just health optimization in general.

0:43 He's coached way more people than I have and he's a genius. I've been reading his books going back probably five or six years now. that he's had on his website just to like his ebooks and everything. But he has been using SOUPP332 for like six years. And obviously I just found out about, you know, not even a full year ago and have been exposed to its amazing benefits and what it can do to help with mitochondrial health. So at a high level, I think everyone in this space, in the biohacking health optimization space The big theme of the next couple of years is probably going

1:15 to be mitochondrial health. Because when we look at mitochondria health, we'd look like a lot of a chronic disease that is taking hold in our world today. Um, a of it can be traced back to mitochondrion dysfunction, lot, of other things, hormone, you know, levels and all this stuff. But, um, A byproduct of that, is mitochondrical dysfunction and people that have no energy, no ability to, You know? Ambulate and have energy and excitement in life. A lot times have mitochondrials dysfunction. So, Obviously mitochondrial peptides, mitochondria agents that help stimulate mitochondrion function are big and rightfully so because they have an amazing

1:53 effect on the body. However, there's one caveat to that and this is something I learned from Alex that you should go check out all of his material. We've talked about this in live streams. Um, but I kind of want to go deep on this today and just kind bring it down to like a more elementary understanding. Cause I had to learn this for myself is what's happening when we increase the spin of the mitochondria. So, um, at a high level or mitochondrial in the cell are spinning and they're producing energy. And, uh, in process of accelerating production of energy by the Mitochondria, we have what are known as reactive oxygen species get thrown off and potentially

2:29 long-term cannot be good. What we want to talk about today is like how to find the sweet spot of optimizing mitochondrial health to have more energy, to more fat loss, just overall vitality in life, but also to mitigate any of the consequences of that. So I know to the lay person, they would say like, why would I even do that to begin with? Well, it's because high functioning mitochondria for the long term of our health are good because it means we can live long and live strong. uh, you know, have lots of energy, uh well into old age. Um, so it's always going to be kind of like, how do we find that sweet spot?

3:00 You know? It's the same thing with hormone levels, testosterone replacement or testosterone optimization is great, but I also don't want to like blast my testosterone in the stratosphere for my whole life because then there's going be a cascade of consequences. And so what we're going talk about today is like how to use some of these mitochondrial agents, then also like to offset any of the negative impacts that can have on us long-term. So, um, that's what I'm going jump into today. Um, as always check out the peptide cheat sheet. I've got, um, all the mitochondrial peptides that I know of on there. Um.

3:30 You know, how to mix them and everything like that. So check that out. They'll sign you up for the email list and as, always checkout fully optimized health, the best community on the planet, uh, to learn about all this stuff as we embark, on this new era of health optimization, where people are taking charge of their own health. Uh, without further ado, I'm gonna share my screen and today we're going to about mitochondria overspend and what to do about it. All right. My name is Hunter Williams and today we're going to learn about mitochondria overspend, what it is and what to do about it. So let's jump in. I think you guys are really going like this. What does this mean? Well, I did make this video having any delusions or illusions about there being a lot of search terms around this.

4:08 Cause it's probably not something people are searching for. So I think this is probably gonna be one for the algo as they say. But hey, let's see what it does. It's basically a term that describes a state in which the mitochondria, which are your cells powerhouses are overactive leading to excessive ATP production and ultimately metabolic stress. Um, so it can be triggered by various factors, but for us in particular, most likely it is going to be for mitochondrial stimulants. Um, excessive calorie intake, uh, certain drugs can do this or even aggressive other biohacking inventions. Um. And when I say that there's probably some like, you know, actual devices out there that are good at doing this, but it's just something that we'd also

4:42 want to be on guard. So how does this even happen? Where do we, where do, we uh go to even cause this? So the first way is going to through excessive elective or excuse me, excess of electron transport chain activity. So high doses of mitochondrial enhancers like SLU, PP332, MOTC, SS31, methylene blue, or even high dose CoQ10 can accelerate ATP production beyond the cell's needs. In a lot of cases, this is what we're doing actually. And this why, you know, typically more athletic people actually need less of a dose than more unhealthy people of these.

5:20 For instance, like a sick person can take SL you at like two milligrams, which is a And they'll need that much to get things going, whereas an athlete would never be able to take that, much because it would just be too much, because their mitochondria are already functioning at a high level. So it's kind of beyond what sox needs. This increases mitochondrial respiration, but also raises reactive oxygen species, otherwise known as ROS, which can damage cellular structure. What are ROS? Because that was one thing I know when I was, you know, years ago learning about all this stuff that I like, like you hear a lot of people on podcasts,

5:54 reactive oxygen species, what does that actually mean and where does it come from? So basically it's just harmful molecules that form as a by-product of energy production. So while some reactive oxidant species is normal, just as part of our day-to-day life and help with cell signaling, too many can cause oxidative stress, which leads to cell damage And ultimately inflammation, which then causes accelerated aging. So just thinking as a byproduct of creating energy within the body. Kind of like when you go in your car and your card, uh, spits out smoke, you know, or exhaust out of the muffler.

6:26 Um, that's a bi-product. Of the energy that is created by the car. And I don't buy into this, but like ultimately, yeah, if you have too much of that by- product, uh, smog in the city, right? And you'll have environmental damage. So ultimately it kind of harms in long run, the energy is created that we need in a short term. At least the cell damage, inflammation, and accelerated aging. It's a good way to think about it. Also too, what happens is we have this imbalance between NAD plus and NAH. Minus chondroloverskin basically can deplete NAAD plus too quickly, which disrupts redox balance and causes metabolic stress to the body.

6:59 And this can make cells temporarily less efficient at energy production. which lead to crashes, fatigue, and symptoms similar to metabolic burnout. For anyone that's ever competed in a bodybuilding competition like I have, you can kind of feel this when you get to like those last two to three weeks on prep where you're basically just dying. I called it running on spirit when I've done that before. But you just like fatigue. You just feel maxed out, like adrenal fatigue kind that feeling of like nothing you could do can make you like energetic.

7:30 And when we cause this imbalance through excessive mitochondrial activation, it kind of leads to this metabolic burnout. So like, you know, we're burning it at both ends, basically. The next one is calcium and ion dysregulation. Excess mitochondria activity can lead to calcium overload, which triggers apoptosis, otherwise known as cell death in some extreme cases. This is often seen in neurodegenerative conditions where mitochondrion dysfunction contributes to cell loss. So that's another byproduct. And then we have heat and metabolic stress. So increased ATP demand leads to greater heat production within the body.

8:04 You've probably felt this. If you've taken SLU, like when you're doing cardio or exercising, you literally feel your body like heating up. Ultimately, in the long term, this can stress cellular function. So this often, you know, a lot of people, they have night sweats, increased heart rate and poor recovery after exersion. Obviously this is like dose dependent. So if you take, 100 or 200 micrograms of sleep, is this going to happen? Most likely not, depending on your metabolic health. However, the higher you go or the longer that you'll take it, some of these things are more prone to happening.

8:35 That's what it is. That basically what's going on in the body. We've taken our car and we've revved it up so much that it's throwing out all this exhaust that ultimately is going to cause this damage by creating smog. in the city, right? If you think about that analogy, so how do we stop it? So first is going to be slowing down the stimulants. So if you have been blasting SLU at two milligrams a day, you know, 60 milligrams of methylene blue a, blue today, uh, a ton of Matzi or a tone of high dose CoQ10, which I think is less popular, obviously taper the dose. We don't want to, we don' want too stack too many of these things at once.

9:08 I don''t want be on SL U plus methyline blue plus Matze plus SS 31, all the big doses at the same time, because this is what's, you know, it's going to happen. We're going have this burnout that comes. Um, we also want to replenish NAD plus and antioxidants. You can use N A D plus precursors like N M N or N R, uh, to restore balance. you could definitely to inject N 80 plus, I didn't write that on there, but, um, another part in all this, and we'll talk a little bit more about this is injectable glutathione. So antioxidants like glutothione, vitamin C, astaxanthin or urolithin A, which is another big one, help mitigate the oxidative stress.

9:42 And again, think about reactive oxygen species. Oxidative stress. Anti-oxidants, glutathione, vitamin C, Urolithin A, are going to help mitigate that oxidative. So if we're using SLU, definitely a good idea to have injectable glutothione in your protocol at least a couple of times a week. Also, we want to increase recovery and rest periods. We want allow the body to return to homeostasis by reducing high intensity exercise and the amount that we are fasting. So we kind of want to put the body in more of a parasympathetic state, parasympathy state because if we're driving, you know,

10:14 sympathetic, which is, fighter flight all the time, sympathetic all time. Boom, boom, Boom. We're increasing mitochondrial spin. Eventually we going to have, consequence of that. Prioritize, especially like in our cycling periods, how you would, use sleep relaxation and lower sympathetic nervous system activation, while using these or in your off cycles. And then two, what I'm going to go into next is mitochondrial uncoupling agents. Now, before you lose your mind, because some people, the moment they hear this, they're like, oh, stay away immediately.

10:46 And I want to talk about these obviously in moderation and obviously ones that are safe. But controlled mitochondria coupling agents can dissipate excess ATP production as heat. So this should be done cautiously and under controlled conditions and obviously with things that are proven to be relatively safe, at least from an anecdotal and research standpoint. So what are mitochondrial encouplers? So, this is kind of like the answer to mitochondria overspend, right? And let me explain. So they are compounds that dissociate oxidative phosphorylation from ATP production, causing mitochondria to burn more fuel while producing less ATP.

11:26 This process converts excess energy into heat, reducing the efficiency of ATP synthesis while still maintaining cellular respiration. So think of this kind of as like a filter that you're putting on your exhaust to keep so much oxidative waste or, you know, bad chemicals, not bad, chemicals but like, a waste product coming off of the increased energy that they're having. So in normal mitochondrial function, electrons pass through the electron transport chain, pumping protons across the inner mitochondrial membrane to generate ATP.

11:59 Uncouplers create leakage of protons, bypassing ATP synthase, which results in increased energy expenditure, lower oxidative stress from the increased amount of mitochondria spin due to reduced electron backflow and ROS production. and enhanced mitochondrial resistance which prevents excessive ATP buildup in metabolic stress. So again, remember what we said that all these mitochondria stimulants or activators are increasing this. Now we can come in with the encouplers, whether in conjunction with or in the off periods of using these to help offset the damage and ultimately get the

12:37 best of both worlds, which is fat loss, muscle building, anti-aging, feeling good, energy and all those things. Let's go in even further. How do these uncouplers offset damage from mitochondrial stimulants? So they work by enhancing, again, electron transport chain activity and increasing ATP output. This can lead to excess reactive oxygen species production. So more oxidative stress and cellular damage, mitochondrial overload, and metabolic rigidity. So the uncouplers balance this out by allowing mitochondria to burn excess energy without creating ATP, which prevents the ROS accumulation.

13:16 It keeps electron flow efficient and reduces oxidant stress. it helps us maintain metabolic flexibility. Again, the holy grail. so it ensures mitochondrion do not become overly efficient to the point of dysfunction. again, if we're bringing them too far in one direction, eventually we are going to have dysfunction And ultimately too, it improves energy expenditure, so it increases fat oxidation and thermogenesis, which is ultimately what we're doing this to begin with, right? We're not increasing our mitochondrial spin just for the sake of it. We are doing it because we want to feel better, we wanna have fat loss, and we don't wanna do all these things. So this is a way to do it and mitigating the side effects.

13:47 What is the mitochondria on the cup? Well, some of these are stronger than others, obviously, but let's look at them. One, We have berberine or dihydroberberin. I would recommend dihydrobuberin, If you're using berberine HCL, I'd say 500 to 1500 milligrams per day. If it's dihydroberberin, which I would recommend because it is way better and it has less of an effect on your stomach if there was bad effects from berberein for you, and I will do that at 100 to 300 milligrams a day, but this is going to improve insulin sensitivity and also enhances mitochondrial efficiency.

14:17 I actually take at least usually 200 milligrams of dihydroberberane per to help with just kind of removing some of the oxidative stress from eating carbohydrates on training days. Then we've got capsicum, so from chili peppers, two to six milligrams per day. It activates thermogenesis via the UCP-1 and brown fat. Methylene blue at a low dose. So the trick with this one is that like at low-dose, methylene blue can be an antioxidant, the higher the dose goes, It increases mitochondrial activation,

14:49 but it enhances mitochondria function and acts as an antioxidant at low doses. So I think like half a milligram to four milligrams, which would be a super low dose of methylene blue. Funny enough, the peptide AOD9604 enhances fat oxidation and mildly uncouples mitochondrion. I would do that at 200 to 500 micrograms per day. Um, usually you could do it like five days on two days off or you would do on, you know, before fasted cardio works really well, like an hour or so before faster cardio. Um can literally like feel, feel the fat melting off of you when you're doing your fast cardio, um, next one is to be, uh,

15:25 hopefully I don't mispronounce. This is so little. Salicylate, other known as willow bark or aspirin, 80 to 325 milligrams per day, reduces inflammation, acts as a mild mitochondrial encoupler, so low dose aspirine. And then lastly, I think a really good one is urolithin A. I've been using this a lot. 500 to 1,000 milligrams a day and it supports mitophagy and mitochondria efficiency. And then lastly, um, one of my favorite things to talk about is L carnitine. I think the injectable is better. And I would do 500 to 1000 milligrams, uh, intramuscularly per day.

15:58 You could go up to 2000 milligrams or even higher, for more fat loss. The only issue with that is it really burns when you inject it. I would say it burns as much as it creates post-injection pain. Um, so it's kind of one of those things like inject as you can really tolerate I'll say, but I kid you not, like I've been doing a thousand milligrams a day recently and man, it just enhances everything is so much better. energy, fat loss, muscle building. But basically it's an uncoupler. It enhances fat oxidation by increasing fatty acid transport into mitochondria, which mildly supports mitochondrial uncuppling and metabolic flexibility,

16:32 best taken pre-workout or with a glucose disposal agent like dihydroberberine. Works well. And then obviously I would say un-couplers to avoid would be DNP. So that's like the more popular one. that I was hinting at earlier. It's extremely powerful and good at what it does, but it's very dangerous. There's a very narrow margin of safety, meaning that if you take just slightly too much, it can be really bad, and people have died from that. So stay away from DNP, even though it is out there. Now, what I did is I created basically a year long program around mitochondrial support.

17:06 So one of the more popular questions I get is like, can you just do like a a long peptide calendar of what should I take and when? And the answer is not really because everyone is different. Everyone has different goals. They have different needs and wants and everything. But I do think when it comes to like mitochondria function, we can look at like okay, independent of like whatever my goals are, I want to optimize mitochondrion function which lean, super fit, healthy people should do and also sick and flame people. So when I look at a year long program, I can actually like kind of come up with a generalized one that I think would work well for everyone.

17:38 That is a typo. I meant to put 200 micrograms per day. Don't read that off the slides, that's 200 micrograms a day, but SLUPP332 five days on, two days off at 200 I think athletes would go up to like 400 to 600 micrograms per day. Urolithin A at one gram. I would do this on my off days and then injectable glutathione 100 milligrams intramuscularly on off day, so this is going to be mitochondrial biogenesis, mitophagy and cellular energy production focus for month one.

18:09 And then I'm moving them on to Matzi, five days on, two days off, same thing at one milligram per day. I've actually noticed if you do intramuscular Matzzi it actually tends to work a little bit better. Um, I would do injectable glutathione again at a hundred milligrams on my off days intra muscly and then injectible L-Carnitine, uh, you know, 500 to a thousand milligrams I am three to four times per week. And, during this time it's going to help with glucose metabolism. mitochondrial stress resilience and fat oxidation. And then my three, I'm going to move to, uh, SS 31. So I actually going dose that the exact same as Matzi.

18:41 Um, five days on two days off at one milligram per day, you could substitute the SS 30 one before Matz. There's a school of thought that like the S S 31 before the Matzie makes it work better. I would do AOD 9604 three to four times per week before my fasted cardio, do 250 micrograms. It seems to be the sweet spot for me. You could do 200 to 300, I like 250. And then injectable glutathione, again, 100 milligrams intramuscular on off days. I liked that usually like two to three days per a week. Then my focus is going to mitochondrial protection, repair, and enhance fat oxidation.

19:14 My fourth is gonna be kind of my deload phase. So I'm not gonna do a mitochondria stimulant. Um, I'm going to do injectable L carnitine again, 500 to a thousand milligrams intramuscularly three to four times per week or as much as I can tolerate. I would love to go higher, but sometimes man it does, it is a doozy to inject. And then I went to low dose, low-dose methylene blue. So 0.5 to two milligrams per day. Again, a very low dos and then again with the injectible glutathione. 100 milligrams intramuscular on off days. And the focus here is going to be mitochondrial recovery, reducing oxidative stress and ultimately metabolic flexibility.

19:47 You notice injectable glutathione is a big one on here. I have a comprehensive video about that on my channel. Probably should do an update one just based on some stuff I know now versus then, even though it's something I've been using for years. But yeah, that would be my month four. Then what I would do is after that, I will just repeat that cycle two times a year because that ends up in 12 months. um to kind of keep things going and that way too you also don't build up a tolerance to any of those peptides uh super fast but why does this work because it prevents burnout cycling the mitochondrial stimulants ensures mitochondria don''t become overlying on specific compounds um it balances ATP production

20:20 and oxidative stress so again remember don' t want too much oxidated stress from the ATP but we do want the fat burning so this helps um we pair the the stimulant with the uncoupler It prevents energy overload in the accumulation of reactive oxygen species. It enhances fat loss and performance. Ultimately, that's the whole reason we do this, right? So alternating between the fat oxidation phases and recovery phases optimizes our metabolic flexibility and keeps us firing all cylinders to make sure that we are losing fat or don't accumulate it. Um, over time and then it supports longevity and cellular repair.

20:50 So SS 31 mod C and your little today, um, ensure mitochondria function efficiently over the longterm. And ultimately that is a goal in all of this of what we are attempting to do. That is it for the slides and that. Is my take on a mitochondrial overspend. and what we can do about it. So hopefully that makes a little bit more sense now. Cause I know when you hear all these high level things, I get it, it's hard enough to even hear the word Matzi. Try to spell that, try to go look it up and buy it and then get at your house and mix it in use it right. I understand that all of these things have really crazy names to begin with.

21:23 Hopefully on your journey, this is a helpful video to kind of help you understand what's going on. when we increase basically the activity of the mitochondria and how it kind of throws off. So I think the best analogy, like I said a few times, is think of your car. When you increase the output of you car, it's going to throw off more exhaust which ultimately can contribute to smog in the city, which is not good for the long term. You don't want to be rocking around in smogg because it causes us to die. And, uh, ultimately that's what's happening. If we increase mitochondrial spin, we're going to throw off more reactive oxygen species, which is not good for the longterm.

21:54 So we can kind of use mitochondria on couplers in a smart way to prevent the damage that would come from that, but also get the best benefits of having like a high horsepower car. Um, hopefully that makes sense. You guys, I'd love to hear your feedback on this one. I know this is kind. Taking a more, um, complex topic and breaking it down. Hopefully this was helpful. and educating you and then also too from a practical take away like how to do it well there it is there's the you know six or seven supplements that you can use to really get the most bang for your buck out of my mitochondria so i would love to hear your thoughts and feedback on this one and again just

22:27 close out i am so grateful each and every day i literally get up so excited to get to the things that i do and help you educate and change people's lives in the way. So I'm humbled and honored every day and just appreciate you guys love you so much. Anything you do to help support the channel, whether it's leaving a like comment, I know I can't always get back to the comments because there's just so many and so things I am working on. But I really appreciate your guys and know from the bottom of my heart, thank you for the opportunity to be able to serve you. That's it for this one. I'll close it down and see you in next one, peace.