PT-141 How To Use It For The First Time And Beyond
PT-141 is one of the more interesting peptides out there because it works for both men and women. It targets the brain instead of blood flow, which makes it different from anything in the Cialis or Viagra family. Here's everything you need to know to use it effectively, plus the stack I'd build around it.
What PT-141 Actually Is
PT-141, also called bremelanotide, is a peptide used for sexual dysfunction. It was originally designed to help women with sexual desire and arousal, but men can use it too.
It comes from melanotan-2. If you know melanotan-2, you know it has a side effect of causing erections, sometimes longer than wanted. Some smart scientists isolated that side effect and turned it into its own peptide. That's PT-141.
So you get the sexual arousal benefit without the skin-tanning side effect or the orange tint people hate from melanotan-2.
How It Works
PT-141 targets the central nervous system. It binds to melanocortin receptors MC3R and MC4R in the brain, which influence sexual arousal and desire.
In plain English, it makes you more aroused mentally. Cialis and Viagra work on blood flow. PT-141 works on the brain. Totally different pathway.
This is why it works for both men and women. Women dealing with FSIAD (low sexual desire and arousal) can see real improvements. Men get an alternative to ED medications, especially helpful if you've built up a tolerance to Cialis or Viagra.
I've also noticed something interesting with peptides that hit the melanocortin receptors. There seems to be a general boost in well-being and a reduction in anxiety. Jay Campbell and I have talked about this a lot. I can't tell you exactly what's happening, but it's there.
Side Effects
The common ones are facial flushing, nausea, and headaches. If you've used melanotan-2, you'll recognize these.
In rare cases people report hyperpigmentation, vomiting, or respiratory issues. I think that comes from overdosing it repeatedly.
In my experience, the flushing and nausea clear out in 10 to 15 minutes. Just be aware of that when you're timing things.
I'm not a doctor. I'm a guy on the internet who knows a lot about this stuff. Take it for what it's worth.
Dosage
Start with 0.5 mg (500 mcg). PT-141 typically comes in 10 mg vials, so check my reconstitution videos or grab the peptide cheat sheet to see how to mix it.
If you've never used a peptide before, you can start even lower at 250 mcg and see how you respond. From there you can titrate up to about 2 mg if needed.
The dose is the same for men and women. With most peptides, the dosing doesn't really change between sexes, even though that feels weird. Women might want to start a bit lower than 500 mcg just to see how they react.
Administration
Use a subcutaneous injection. You'll see PT-141 sold as an intranasal spray on research chemical sites and you can absolutely do it that way. I just don't like snorting things up my nose. It irritates my sinuses, and it's harder to measure exact dosing through a spray.
Inject it 45 minutes before sexual activity. That's the sweet spot. It gives any flushing or nausea time to clear, and it lets you ease into things.
The effects last about 2 to 4 hours.
My Sexual Arousal Stack
Here's what I'd actually do if I wanted to hit every pathway without overloading any single one. Smaller doses of multiple things, hitting different mechanisms.
PT-141, 500 mcg. Injected 45 minutes before. This hits the nervous system pathway.
Cialis (tadalafil), 5 mg. Most people take 15 to 30 mg for ED, so this is a low dose. The liquid research version is cheap and easy. Cialis works on the vascular system, so you're covering blood flow. You can take it any time during the day, doesn't have to be 45 minutes out.
Oxytocin, 25 to 50 mcg. Be careful here. Both PT-141 and oxytocin can cause flushing, so you don't want to stack them too high. Oxytocin handles the bonding and intimacy side. I'd inject it separately from the PT-141, also about 45 minutes before.
N.O. Beets, one serving. This is a nitric oxide supplement from Dr. Nathan Bryan. I don't hype normie supplements, but this one is genuinely good. It hits the nitric oxide pathway, which complements the Cialis on the blood flow side. No affiliate code, just a product I've used.
So you've got the nervous system covered by PT-141, blood flow covered by Cialis and N.O. Beets, and bonding covered by oxytocin. Different pathways, smaller doses, better overall effect.
For women, you can do this same stack. 5 mg of Cialis is low enough that it's not a problem. And if you're a man who doesn't want to add Cialis, you can run PT-141, oxytocin, and N.O. Beets and still get great results.
My Take
PT-141 is a solid option, especially if Cialis or Viagra haven't worked well for you, or if you're a woman looking for something that actually addresses desire. It's natural, the side effects are mild and short-lived, and it works on a pathway nothing else really touches.
Start at 500 mcg, inject subcutaneously 45 minutes before, and see how you respond. If you want to go further, build the full stack and hit every pathway at once. That's the holistic approach to sexual health if there ever was one.
Full transcript click any paragraph to jump video
Hey everybody, this is Hunter Williams. I hope you were doing amazing wherever you are at in the world. Today's video is going to be all about PT 141. So PT-141 is a peptide that people use to enhance sexual function. And the cool thing about it as opposed to some of the larger sexual functions or erectile dysfunction medications like Cialis or Chidapho is that women can use it. So yes, this was actually originally designed to help women with sexual function and increase their sexual desire and sexual arousal. What I'm going to be doing today is just giving you a total comprehensive breakdown like I usually do in my fashion and style of exactly everything you
need to know about PT-141. Uh, kind of where the mechanisms are in the body. Where did it come from? Where do you get developed as well as any side effects and then also the dosage. And lastly, if you stick around the end, or if just want to click on the chapter titles down below, I'm going to be talking about some other things that you can stack it with. Usually I do like a peptide stack section at the But what I'm gonna do today, it's not necessarily a peptide stack section, but it is going to be basically a stack that I would use if I were gonna use PT-141 to optimize sexual function and optimize all those pathways that are
going help with sexual performance. So this is gonna be very analytical. I am not gonna give you like some crazy like Playboy type view of PT 141 or anything like that. And that's just not personally how I roll. But today I will be talking about it include all that stuff. So before I jump over and share my screen, just a quick plug if you want to sign up for the peptide cheat sheet down below. I actually will update it hopefully by the time this video goes out with PT-141 so it'll tell you how to reconstitute it, how much water to put in the vial, and how And then also, if you want to ask questions or have comments or anything like that,
drop them in the comments below. And the reason I say this is because YouTube has been turning off the comment on a lot of my videos. So I do want you to know if the coments are off for any reason on this video, it's not me. I want comments on the videos because it helps get the information out to more people. Just know that for whatever reason, YouTube obviously doesn't really like me because they deleted my old channel. But anyway, leave comments bellow if have questions, or just know they're off, I'm working to get them turned back on. Because they will let me turn them back but they'll do it like on random videos at random times. So anyway, without further ado, I'm gonna share my screen and today we're gonna break down PT 141. All right, so this is going to be a comprehensive overview
of PT-141. My mission with this presentation and video is for you to leave and be able to use PT 141 at your leisure, wink wink, any time that you want. So let's get into it. PT142 is known as bromelanetide. Basically, it's a groundbreaking peptide with significant potential in treating sexual dysfunction, like I mentioned. Let's talk a little bit about the mechanisms behind them. So, like I said, it's called bromelanotide, I always mispronounce that, but bromelinotid.
It's basically a derivative of melanotan-2. So if you know anything about me, you might talk sometimes about melanoton-1. I'm not a big fan of melanoton 2. Melanontin- 2 has this added, wanted, or sometimes unwanted side effect of giving you pre-opasms, which is basically for men, that means an erection for a long period of time. That can actually be very uncomfortable for men, but some guys actually use Melanotan-2 to get the sexual enhancement and sexual arousal side effect from it. Now, what they did in creating PT-141 is some pretty smart scientists got together and they're like, okay, well, Melantan 2 causes a side effect.
Can we isolate that side-effect and actually get the benefits without any of the other side effects? So that was originally how this came about. So obviously Melanin 10-2 was really originally developed for skin tanning by stimulating melanogenesis. And the unintended effect of that included sexual arousal. This was isolated through PT-141 to help treat sexual dysfunction. It's a pretty unique approach. Erectile dysfunction or sexual arousal medications treat blood flow, which isn't necessarily wrong, but PT-141 works completely differently than all those
because it works on the melanocorticoid receptors. So basically instead of treating like bloodflow, we're looking at the central nervous system. And then again, it worked for erectile disfunction or FSIAD, Which is basically like women's sexual dysfunction, kind of like the same thing of erectiles dysfunction for women. So, kind of one of those things like you take something that's good and then you turn it into something better. You take a side effect and isolate that side-effect. So let's look at the mechanism of action here.
PT-141 targets the central nervous system unlike conventional sexual dysfunctional treatment. It binds to the melanocortin receptors MC3R and MC4 in the brain. So what this does is it influences sexual arousal and desire. So it actually is making you quote unquote more horny in your mind by influencing these receptors, which is weird because like the melanocorticoid receptors are typically associated with skin health and everything, but this is how it works. This is obviously groundbreaking for addressing the neurological components of sexual function where people are just not interested.
Now, I will say that a lot of times that's a hormonal deficiency as well, not only in men but also in women. Typically, women lack the requisite hormones that are going to cause them to have sexual desire, for the most part. But basically, these peptides do not directly affect blood flow, which I'm going get to later in this presentation to talk about how we can stack these sort of things, with this for insurance, obviously, from other ED drugs. So you've got to be careful, because when you're doing this, you want to know what you are doing from a dosing standpoint and everything. Also, the specificity of receptor targeting, minimizing the side effects related to non-targeted areas.
So again, with Melanotan-2, we're not getting that weird orange skin tone. We're getting as much of the unintended side-effects that everyone hates from Melantan 2 with PT-141, which is pretty cool. What are the benefits? So it benefits both men and women by addressing sexual dysfunction. So women with FSIAD see improvements in desire and sexual satisfaction. It's pretty cool for women. Not only does it improve sexual health, but as a consequence of improving sexual, health is going to improve other areas of well-being.
However, for men, it provides an alternative treatment for rectal dysfunction especially. What can happen a lot of times with Cialis or Viagra is that men start to build up tolerance to these medications, so they have to take a larger and larger dose. And what I'm gonna talk about in the stacking section is how you can minimize the dosage of some of these medication and peptides and different things to maximize sexual desire without overloading one pathway. So what's cool about this is I have noticed this obviously with Melanotan-1, because I talk how it enhances consciousness,
but when we enhance the melanocorticoid receptor and allow the body to have enhanced function in that sense, it improves our sense of well-being because of how we absorb sunlight. And I don't know what exactly specifically is going on there, but Jay Campbell and I have talked a lot about this, so you're kind of getting the same thing with PT-141. Now, obviously, you aren't getting this skin-tanning benefit, which we're getting is overall enhancement in consciousness, this overall reduction in anxiety, kind-of sense well being that comes from that.
You know, obviously offers, you know hope for people that take Cialis Viagra or other women's equivalent of those medications and don't really get results with those. So I think a lot of people would be good to do this and obviously the peptides, it's all natural. You don' really have anything to lose in terms of like side effects or like unwanted things that could be very dangerous or anything like that. So obviously some users report enhanced experiences, sexual encounters, not only from, you know, like a, I guess like arousal and erection standpoint, but then also the experience itself.
So basically what we are doing is targeting the nervous system and not blood flow with PT 141. Obviously, this could be a pretty big thing for sexual health if it becomes mainstream. So, can't be all good, right? What are some of the side effects? So common side-effects include facial flushing, nausea, and headaches, which if you've ever used Melanotan-1 or Melantan 2, not so much with Melatantin-2, but definitely with melanotin 2. You know that's a symptom of hitting this melanocorticoid pathway. So in rare cases, PT-141 has been noted to cause hyperpigmentation, vomiting, respiratory issues.
And I really think that probably comes from overdosing it too many times, which I'm going to get to in the dosing. But the side effects, especially like the flushing, the nausea, or the headaches, those typically, in my experience, go away in like 10 to 15 minutes. So if you are using this, just be cognizant of timing, because I know timing can be delicate. when it relates to sexual activity and everything. But obviously, too, I'm not a doctor. I just got on the internet that happens to know a lot of stuff and publish a lotta information about this. So take for that what you will. Now, let's look at the dosage.
The dosages is very, very straightforward. I would start with 0.5 milligrams, also known as 500 micrograms. So basically there's a thousand micro grams in a milligram. 500 micrograms is half a milligrams. Now typically you're going to see PT-141 in 10 milligram vial. So, again, check out my videos on reconstitution. Check out the Peptide Cheat Sheet. But basically, it's very simple to take a 10-milligram bio, reconstitute it to get that amount that you need into one injection.
So here's where we get to the administration method now. You will hear people out there and you're going to see it sold on research chemical company websites to do intranasal spray. You can absolutely do intranasal spray with PT-141. You could probably do it and get good results with it. I am just always of the opinion, use subcutaneous injection. For me, that's personal preference. And I don't like snorting things up my nose. It irritates my nos, it irritate my sinuses and everything. It's very delicate to try to measure out how much nasal spray is actually coming out.
When you do it, and there's an added step in the reconstitution, I always just stick with subcutaneous injection. That's for pretty much all peptides. Really, when do they have that you administer intranasally that can't do subcutaneous or intramuscularly? injection so I personally would use it as an injection but if you have a fear of injection for whatever just know that you can technically use this as intranasal injection. So start with 500 micrograms or 0.5 milligrams and then if need to go up in dosage You can go up to two milligrams.
This is the first time you've ever used a peptide or especially PC-141, maybe even start smaller, 250 micrograms and just see how you respond. You might not see that big of a benefit from it, but you can kind of go from there. That's a good starting point, and then as you get more comfortable with it as, you're getting more familiar with, we can kinda like titrate and see. Now, as far as timing goes, You want to do this about 45 minutes before sexual activity. So that's kind of a sweet spot because this has a pretty short half life. I forget off the top of my head of what the half-life is, but you want make sure that it's around 45-minutes.
One, that is going to give you time to clear out any flushing or nausea or anything like that that would come right away after you do the injection. And then two, it is basically going allow you to ease into sexual activities. You can now foreplay everything and then hopefully as you are getting to the climax, no pun intended, you are maximizing the benefit and the effect. But typically the intended effects aren't gonna last much longer than like two to four hours. And obviously that's dependent upon the arrival pathway.
So you're not gonna be like, have your deal and then go out and like go chop wood in the yard and think that you have to worry about it. Maybe, but it's just not my experience. Obviously like with peptides, personal tolerance is very, different based on your body size and everything, but I will say this dosage is the same for men and women. Maybe if you're a woman, start with a little bit lower dose than half a milligram, most peptides are all gonna be the the dosing for man or woman. I know that sounds weird, because if look at androgens or you look like some supplements you would argue men would need way more of stuff,
which in those cases they do a lot of times. But for peptide, it's just very, very close aligned in a dosages for women and men. I would say that's the same dosage for women as well. Now, here is where I kind of built this thing of like what I would call the ophthalmol sexual arousal stack. So, what would I do is I'm going to take PT-141. I am going start with .5 mg, 500 mcg of PT 141 injected 45 minutes before I intend to have sexual activity.
Then what am I going do, is use 5 mg of Cialis or Tadalafil.I like the liquid version of that that you can get from research chemical company websites, which I can't Publicly promote, but if you sign up for make me all this you'll see where to get all of this stuff for very cheap And you don't need a prescription and you just have to know that it's not sold for you know human consumption that's sold For research purposes only but what I would do is during that day You don' t have do the Cialis 45 minutes before you definitely could but you can take the cialice any time of day So we've got PT-141,
five milligrams of Cialis. Now, if you know anything about Cialsis, you'll know that's a really low dose. So what we're doing here is we are taking like smaller doses of things that are hitting different pathways to optimize like overall sexual function and well-being. Um, so what I would do is take five mg of cialus, that is a low-dose, most people for sexual functions take 15 to 30 mg, we'll do 5 mg. So, Cialis works on the vascular system and PT-141 targets the nervous system, which is going to hit two different pathways to stimulate the best arousal
and desire and function as it does. Now, what I added in is oxytocin. You've got to be careful with this. If you want to do a little bit lower dose than you probably normally do with oxytocin. like 50 micrograms, maybe even like 25 micro grams, because if you take oxytocin with PT-4 and 41, one side effect that both of those will have is that flushing effect, so you just don't want to overload your system with flushing, but you can definitely do them. I would do in separate injections just because I've never done them together in one syringe, which you could inject them both at the same time, and again, the timing for oxytocin is very similar in terms of how early you want do it related to the sexual activity.
So again 45 minutes before, So this is going to basically enhance the sexual intimacy. It's not going necessarily work on like blood flow or even the nervous system like PT 141 does, but it's going enhance intimacy and bonding with your partner. Assuming that's what you want to do. I think that what most people want do, that is what I want. But assuming that that you what to. Now, what I've added is this supplement called N.O. Beats. It's actually developed by a guy named Dr. Nathan Bryan. I believe he founded the company called Super Beatz, and now he has a company call it N-O-Beatz.
You know guys, I don't like hype stuff up, or I would hope that you know, that's like normie supplements, but as far as normies supplements go, this is like a really, really good stuff. The best pre-workout that I've been able to find that it don't make myself, but basically this enhances nitric oxide. So when you pair this with oxytocin, with PT-141 and with Cialis, you're hitting the nitrich oxide pathway, the blood flow pathway is related to Cielis.
The bonding pathway it's related oxy-tocine and then the nervous system pathway as it relates to PT 141. So this would be like the dream, you know, like pre-date night stack, especially if you wanted to be intimate in a very related way, close and emotionally close with your partner. So here's kind of like that stack. Five milligrams of cialis, 50 micrograms of oxytocin, one serving of NoBeats. You can look that up on Google, just type in No Beats, I don't have an affiliate code or anything like I just know it's a really good product and I've used it before.
And then obviously 500 micrograms of PT-141 and you do that 30 to 45 minutes before sexual activity and your are talking about hitting all those pathways where you're not overwhelming one but you are getting a good effect all around. So that would be the holistic approach to sexual health if you could ever define one. And the cool thing about that is, for the most part, women can do this as well as men. You know, five milligrams of Cialis for a woman is intended to help men, but that's not so high a dose that a women couldn't do it. Now, I am not telling you if you're a man to go take Cialsis or Tadalafel, and you could do all these other things.
So you can PT-141, you do oxytocin, do InnoBeats and still get really amazing arousal and benefit from doing that. That's just my own opinion, but let me pull down my screen. And that is everything you need to know about PT-141. So hopefully that was helpful to you guys. Hopefully it made sense. Again, if you have questions, comments, concerns, anything like that, please let know down in the comments. Let me know if this was help for you, guys, so I can keep cranking out more content like this, because I love doing this stuff. I loved talking about this. Stuff I could talk about it all day. Don't forget to sign up for the email list. Join by signing up the peptide cheat sheet.
Also got my supplement sources list and all those links down there. You know the link to the private community and everything like that, but you guys know, the deal if you're here watching So appreciate you, guys much love out there and i will talk to you in the next video peace
