Why I Inject Estrogen | New TRT Protocol Explained
Before you think I've gone AWOL and started transitioning, hear me out. I've been running injectable estrogen alongside my testosterone therapy for months now, and the results for libido, cognition, and mood have been some of the best changes I've made to my protocol. Here's the long road that got me here, and exactly what I'm doing now.
How I Got Here: Starting With Injectable DHT
Back in early 2024, I came across injectable DHT. Different from Primobolan or Masteron, injectable DHT is bioidentical, the same way injectable testosterone is bioidentical.
I started playing with it and at first it felt like God mode. Strength through the roof, physique looking great, mentally sharp. I was running it one-to-one with my testosterone, around 200mg of each per week. At the highest I went 300mg and 300mg.
Then a few weeks in, things started to shift.
My cognition dulled. I was getting tired in the afternoons. The bone pain in my elbows, shins, and ankles, the kind of soreness I used to get before TRT, came back.
For me, those symptoms plus a drop in libido are dead giveaways for low estrogen. DHT is so strong that it suppresses estrogen, similar to how Primo and Masteron act like aromatase inhibitors. Even though I was injecting testosterone to convert into estrogen, the DHT was crushing it.
Finding the Right DHT Ratio
I started experimenting. Two-to-one testosterone to DHT? Three-to-one? For me, the sweet spot ended up around 10 to 15 to 1.
So 250mg of testosterone with 25mg of DHT per week.
I also figured out that DHT enanthate hung around too long and kept suppressing estrogen. DHT propionate, with its one to two day half-life, gives you a nice pulse of the masculine, anabolic, mental benefits and then clears out before it tanks your estrogen.
Testosterone enanthate keeps your test and estrogen stable. DHT propionate gives you the spike. That combo worked well for a while.
The Idea That Changed My Protocol
Then I started hearing about something in bodybuilding circles. Some guys were removing testosterone entirely, running Primo or Masteron for the anabolism, and just injecting estrogen directly to dial in exactly where they wanted estrogen to land.
The logic clicked for me. A lot of guys think they have high estrogen on 500 to 750mg of test per week, when really it's an inflammatory cascade from running test that high.
I didn't want to remove testosterone. But I wondered if I could pair injectable estrogen with my existing protocol to get the libido and cognition benefits without ramping testosterone up to 750mg and frying my central nervous system.
My Current Protocol
I sourced injectable estradiol cypionate at 10mg per mL.
I started small. 250mg testosterone enanthate, 25mg DHT propionate, and just 1mg of estradiol cypionate per week.
Even at 1mg, my libido jumped noticeably. I was thinking about sex more. Sexual function was sharper. So I worked up to 3mg per week.
After a few months on that, I dropped the DHT and kept the estrogen. That's where I am now.
Here's the current protocol:
- 250mg testosterone per week, broken into every-other-day shots (about 65mg per injection)
- 1mg of estradiol cypionate with each testosterone shot (3mg total per week)
- I do the estrogen as a separate injection. It didn't draw through the syringe well when mixed with test.
When I last got blood work, my estradiol was sitting around 45. Without the injectable estrogen I usually run high teens to low 20s because I'm lean and aromatize less.
Why This Works Better for Lean Guys
Right now I'm around 7% body fat. A few months ago I bod-podded at 9% at 227 pounds. I'm 216 now and leaner.
The leaner you are, the less testosterone you aromatize into estrogen. That's just how aromatase enzyme expression works. Someone at 25% body fat on 250mg of test will produce way more estrogen than I will on the same dose.
So my options to get estrogen into a therapeutic range are:
- Crank testosterone way up and hope more aromatizes
- Inject estrogen directly
Option two is cleaner.
I also take metformin, which indirectly suppresses aromatase by reducing visceral fat and inflammation. If you're on an aromatase inhibitor right now, drop it, try metformin for four to eight weeks, and see what happens. You'll probably get a similar effect without harming your health.
Why Most Guys Fear Estrogen
Most guys are actively suppressing their estrogen with an AI. The idea of removing the AI and then injecting estrogen on top of testosterone sounds insane to them.
I get it. But a man's sex drive comes mostly from estrogen, not testosterone. Testosterone matters, obviously. Estrogen does a huge amount of the work for libido, mood, and cognition.
A lot of the benefit guys feel when they bump their test from 250 to 400 isn't from the testosterone itself. It's from the extra estrogen that gets aromatized along with it. So why not just add the estrogen directly and keep testosterone at a reasonable dose?
Estrogen Resistance Is Probably Real
I've talked before about testosterone resistance syndrome, where endocrine-disrupting chemicals make us resistant to our own testosterone. Free testosterone matters more than total.
I think estrogen resistance is real too. If your total estradiol comes back at 100 but it's all bound up or getting kicked off receptor sites by xenoestrogens and phytoestrogens, it's not doing what it should at the cellular level.
That's speculation on my part, but it lines up with what I'm seeing.
Who This Is Not For
If you're 25% or 30% body fat, do not inject estrogen. Your first priority is getting body fat off. Excess body fat is the number one problem in your life if you're carrying it. You're already aromatizing plenty.
This protocol makes sense for guys who are lean, on TRT, and feel like their libido or cognition is flat despite decent testosterone numbers.
My Take
Injectable estrogen has been one of the best additions to my TRT protocol in the last year. 1 to 3mg per week alongside 250mg of testosterone has put me in the best place I've ever been for libido, mood, and cognition.
I'm a chill guy by nature, but the estrogen supplementation makes me feel even more heart-centered, aware, and connected. Not bad for something most men are taught to fear.
Try it if you're lean, on TRT, and looking for that last 20%. Skip it if you're carrying too much body fat. Always run blood work, and as always, your protocol is yours to figure out.
Full transcript click any paragraph to jump video
Hey everybody, this is Hunter Williams. I hope you were doing amazing wherever you are at in the world. Today's video is going to be all about why I inject estrogen as part of my testosterone therapy protocol. So before you think I have gone AWOL and maybe transitioning into a woman, which I assure you I'm not, This is actually going be about something that it's kind of a long, long roundabout way of how I got here. So I'm going to tell a little bit of the backstory about that. And also too, for this video, I don't have any slides or anything, just as a side note of over the next two weeks, we're going be at the biohacking conference
with a booth there. Then we'll also be the peptides conference in Las Vegas that Dr. Seeds hosts. We will be both of those conferences. The next three weeks are going a bit crazy with travel. I'll be doing my best to maintain my normal content schedule. That means that I probably won't have the long, in-depth videos with my slides and everything that normally do. So there's no slides for this video today. It's just going to be me kind of rattling off the top of my head. Hopefully it's informative and helpful to you guys because I have a lot I want to talk about, but just not all the time to aggregate it into slides.
Just a side note for that, this is going be be spit balling and talking about it. Hope you like this too. I know it is not as structured as my normal videos, I think it can be helpful nonetheless. Especially over these next three weeks when I'm just a little bit crunched for time in terms of preparing my slide So anyway, I want to talk about injectable estrogen for men and I might have talked about the backstory first of how I got here and What my protocol is now and i want, to preface this and say that This is my protocol, so this is not going to apply to everyone.
I'm not recommending that everyone do this. But if you listen to what I say today, you can take it and then maybe experiment on yourself and implement it on your self based on how you see your life line up with my personal experience. So let me go back to, let's see, today's May 2025. Let me back back early 2024. So early 2024, I came across injectable DHT. And injectible DHC is different from like a primobolan or a masturon in the sense that for what we know what I know, again,
i'm just talking about my personal experience to be injectble DH T the same way that testosterone is inject, bioidentical DH. T and I started playing around with that and it was incredible at first. It felt like you were just turned into God mode. And what I was doing was adding in DHT at one-to-one to my testosterone dose, so doing 200 milligrams of testosterone per week and then 200 mg of injectable DHt enanthate. So it was a long-acting version of DHP. And so for the first couple of weeks, I felt superhuman mode, right?
It felt, wow, my strength is through the roof. I'm getting ripped and I look amazing physique-wise and feel great, feel mentally great and all those things. And it wasn't like, I've never had a bad response to trend, but it seemed to be like all of the, good things from trend were there without any of the downsides. So anyway, go through weeks, started like playing with protocols, never taking it super high. I think probably the highest I did was like 300 milligrams of tests and 300 mg of DHT together.
It was always kind of in a one to one ratio. And then what I noticed after a few weeks is although the physique benefits seem to keep going, Cognitively, I wasn't as sharp as I normally was I was getting tired in the afternoons and I noticed I Was getting joint pain in my for me my joint not joint, pain, but I would get bone pain. So whenever Before I started testosterone. I notice that my elbows and then my shins and my ankles I always get like really really sore after training and i noticed that That started to happen again.
so I get really tired that afternoon and I wouldn't want to work or have the energy that I normally do in the afternoon. And I also noticed that my ankles, shins, and elbow areas were sore. I was like, okay, typically for me, this is usually a sign of low estrogen because I know having tracked my blood work for years now, for, me that and libido are usually the drivers of okay. No, my estrogen is low. Even if I don't have a blood test done, which obviously the blood tests helps, but this point, when you, you've been doing this for enough time, get used to it and can kind of sense when things are starting to go right.
It's like, okay, it makes sense because other drugs like Purimbol and Mastron seem to work like an aromatase inhibitor and DHT being stronger. Before I misspeak, DHP can be suppressive of estrogen because it is so strong. So basically it can so that it suppresses estrogen. Even though we were injecting where I was injecting testosterone to basically get my estrogen and then use the DHT for the benefit of all the anabolism and masculinity and all those things.
It was so suppressive that I noticed I was getting low estrogen side effects. So started messing around like, okay, what is the ideal range of DHT or ideal ratio of DHE to testosterone? Is it two to one testosterone to DHD? is it three to on testosterone, to DHD? For me, would it end up being, it was somewhere in the neighborhood of like 10 to 15 to 1 to where I notice I would not get estrogen. suppressive side effects. So for instance, I would take 200 milligrams of testosterone a week or 250 milligrams a testosterone per week, and then use 25 milligrams at DHT.
Now, during this time, i figured out that DHC enanthate is a longer acting version of DHP, whereas DHD propionate, which you can also inject, is shorter acting versions. If we use the enantate version, like we used testosterone enatate What I noticed is that the estrogen suppressive effects tended to hang around longer, whereas the appropriate, which has a one to two day half-life, you would get the pulse of the DHT which feels really good, gives you the physique benefits, the mental benefits the kind of masculine like benefits but it doesn't hang long enough.
So if we have testosterone and anthate, it kind keeps our test levels stable and then also estrogen level stable which is much more important in my opinion for sexual function and cognition and joint health. And then the DDT propionate gives us a nice pulse and then it's out and we don't have it hang around to where it suppressing estrogen for the long term. And so I noticed switching esters and also going in like a 10 to 1 ratio somewhere around there. It's like 250 milligrams a test to 25 milligrams of DHD proponate over the course of a week seemed to do really, really well.
So I stayed on that for a while. But there was one thing that I came across and I kind of started hearing about this in bodybuilding circles of guys doing was actually removing testosterone from their cycles. So the thought would be that, okay, a lot of guy take testosterone, 250, 500, 750 milligrams of testosterone per week and they will get quote unquote high estrogen. when in reality it probably is high estrogen at a thousand milligrams of testosterone per week.
But it really is kind of this inflammatory response to all the cascade that is happening within the body. And so yes, high-estrogen can technically be a thing, but I think it's often misunderstood. Just that's my opinion. Anyway, what I started to hear about was guys doing no testosterone, but using basically like a primabolin or amasteron to get the anabolism slash like the testosterone side of things. And then actually just using estrogen injected to control where their estrogen would land.
So rather than using testosterone basically to provide the estrogen in the cycle, and then using primbolin amastron, they would just take the testosterone out, use the injectable estrogen, and then kind of find the ratio for themselves to basically manipulate exactly how they wanted to look and exactly what they want to feel. And I was like, well, that's interesting. I don't know if I want do that. But I wonder if i could pair the injected estrogen with the DHT to, basically, get the benefits. of adding testosterone without adding Testosterone, if that makes sense. Because basically, I don't necessarily want to take 750 milligrams of testosterone per week all the time, because it's going to ramp my central nervous
system up. But in order to get the benefits of the DHT, i would need to go maybe to that high of a level in, order, to keep my sex drive up, Because what I'm trying to do is drive estrogen higher to, keep, my, sex, drive, up and all those things, So I was like, OK, well, maybe let me try injectable estrogen alongside of testosterone plus DHT and see how it does. And so I had no basis for doing this. I didn't know who I did find anyone that was talking about this in terms of dosages. There probably is people out there. that have talked about it, and there are people, I'm sure, that I just didn't find it.
So I was like, well, let me see if I can find and source injectable estrogen, then let's see what the ratio would be. I found injectible estrogen at 10 milligrams per milliliter is actually injectal estrogen or estradiolcipinate. And I took, I think the first time, and this has been several months prior to this, 250 mg of testosterone and anthate. And this is over the week. I'm obviously breaking this in the other day injections. 250 milligrams of Testosterone.
No, excuse me, 25 milligrams of DHA propionate and then one, I started with one milligram of estradiolcipinate per week. And what I noticed is just from doing the one milligrams along side of those things that my sexual function massively got better. And it's not that it was bad before. I didn't even would say it with that before, but I noticed this man, my libido was weighed up and I seemed to notice that I was just thinking about sex more. And I'm like, wow, this is pretty cool. So I ended up going up to three milligrams total of estradiol sipunate per week.
Basically doing 250 milligrams of test, 25 milligrams, a DHT propionate, and then three millimeters of esteroidosipunite. And I did that for several months and it was amazing. The added brain benefits and the added libido boost from the injectable estrogen in that cycle was crazy, crazy good. And from there I was like, okay, well, let me remove the DHT and then just keep the estrogen and say 250 milligrams of test with the estrogens and see how that does. Since then I've been doing that a couple of months now and sexual performance benefits and the cognition enhancement benefits from doing injectable estrogen
are so, so much better for me than just testosterone alone. And my theory around this has a lot to do with increasing testosterone levels and what increasing basically the amount of testosterone we're injecting, how much of that benefit comes from increasing estrogen in our body. Now, When we look at testosterone, we say, okay, if I take my test from 250 to 400, I'm going to have more muscle growth. I am going probably have to more libido than I normally would if it was 250. To a point, it doesn't scale that way, but I will have one of those things.
And how much of that is actually because we are increasing estrogen in the body alongside of testosterone. But what if we could use the same amount of Testosterone and then put a little bit of estrogen alongside of it to increase the libido and the cognition benefits that estrogen provides. And I think that's what has been done in my case and then other cases of people in our private communities to where they're taking 200 milligrams or 250 milligrams of tests. Then you add in two, three or four milligrams estrogen per week to enhance libid and everything.
The difference is night and day. Now I want to preface by saying I am very lean. If I got my body fat tested right now, I'd probably be somewhere. I, so I'm, like two 16 right. Now. And a few months ago I get, got a bod pod done and I was two 27 and that was 9% bodyfat. So I would probably, be, would venture to guess I'll probably somewhere around 7% fat right? Now being conservative and based on the fact that I've kept a lot of my muscle as I have slimmed down just in the last couple of months. That was when I had bulked up this winter and So when I've cut down, I think the leaner a person is, the better they are going to respond to injectable estrogen.
So would I have that same response to the injectible estrogen if I was 25% body fat? I don't think so. But what we do know is that the leaner we are, the less of our testosterone we aromatize into estrogen, meaning that testosterone gets injected in the body. For someone that is 8% body fat, they are going to turn much less testosterone into estrogens than someone who is 25% fat. The higher amount of body fat we have, the more aromatase enzyme expression we, have meaning that the, more our testosterone is going to get converted
into estrogen. So you give someone that is 25% body, fat 250 milligrams of testosterone a week versus someone like me, that has 8% of, bodyfat 250, milligrams testosterone week. I'm going, to have much less estrogen come from that. What are my options to, get my estrogen into a, therapeutic range, just like I am using testosterone to. Get my testosterone into, a therapeutic, range. Well, I can increase my testosterone to hopefully have more of that aromatized into estrogen, or I could take estrogen itself. And that's what I have found to be the sweet spot. I think a lot of guys fear estrogen because, obviously, forget about injecting estrogen.
Most guys are suppressing their estrogen with an aromatase inhibitor, so forget or excuse me, forget about supplementing with estrogen. They're going to suppress estrogen, let alone make the mental block of, okay, now I've got to remove my aromatase in there, but now inject estrogen on top of that. That is just so counterintuitive. But I promise in my case, it has been one of the most beneficial things I have done in protocol. And so now what I'm doing is taking 250 milligrams of testosterone per week, usually broken up into four shots or just every other day. I take one milligram of estrogen with every shot.
Actually break it up in a different shot, I've done it with the testosterone and it didn't seem to go in as well through the syringe. So I just do a separate shot of one milligram of estrogen every time I inject testosterone, which is usually around a 70 milligram dose per time that I'm doing it. Probably 65 actually. But anyway, so I'll do a 65 milligram injection of testosterone with a one milligram of estrogen. And that, I promise far and away for mood, cognition, libido, and everything, for me has been the sweet spot. Now, if somebody's 18% body fat, is that gonna be the same for them?
I don't know. And I haven't got my blood work done in the last couple of weeks, but when I did have it done the first time when i started injecting estrogen, even my estrogen was sitting somewhere around 45. So taking 250 milligrams of testosterone per week plus one milligram of, or excuse me, three milligrams, of estrogen per weak. My estrogen in was in 40s. For a lot of guys, they might not need that because I usually run estrogen when im just on testosterone alone, somewhere in high teens and early 20s because im lower percent body fat. I typically just aromatize less estrogen.
I also take metformin, which is not suppress estrogen specifically, but it does tend to suppress the expression of aromatase because of what it to visceral fat on the body by helping with insulin sensitivity and suppressing inflammation. Thus, when you're taking met formin it actually, in a roundabout way, kind of works like an aromatase inhibitor. So on top of that, I would always just say, guys, hey, if you are using an aroma taste inhibitors, why not drop it, try metormin for four to eight weeks, see what happens and see if don't get the same response.
Plus, you don't have to worry about harming your health. You'll be making yourself healthier. At least, that's my opinion. So what I mean to conclude this video by saying, because I've been going for 15 minutes now, is that injectable estrogen for men on testosterone therapy can be a massive benefit to you if you feel like your sex drive is suffering. In most cases, I think the guys that struggle with that are the ones that leaner, to be honest, and the one that aromatize less, or they're on an aromatase inhibitor themselves.
So, what can injectable estrogen do? Well, for me, in a range of one to three milligrams per week alongside my testosterone therapy, and I know some people will say 250 is not a therapeutic dose of testosterone. Hey, that's okay. I'm a bigger guy.I had concussions when I was younger. My testosterone was basically nothing. So 250 puts me in the best feeling spot and all my blood markers are perfect for where I want to be. But I will that one, two, three, milligrams of estrogen injected weekly made a massive difference in my life and for the foreseeable future, unless something changes, cause I'm always open-minded and willing to change based on the best available data that I have.
It has been a godsend to my testosterone protocol. And I noticed too, I am a very chill person, but estrogen supplementation even feel, makes me feel that much more heart centered, that more aware and in tune and connected than I was before. The last thing I'll close out with is, I've made videos about testosterone resistant syndrome before, meaning that we become resistant to testosterone because of the endocrine disrupting chemicals in the world. You can go check out that video.
What is more important to our testosterone is actually free testosterone than total testosterone. And I don't know if there's a test to do this, I'll have to look this up. I think estrogen resistance syndrome is probably real too, Meaning that it doesn't matter what our total circulating estrogen is or estradiol. If we don't have unbound estradiol to act at the cellular level, and this is just speculation on my part, I think it doesn't matter. So if you come back with a total estrogen of 100, but there's not enough available at a cellular-level because it's bound up,
to bound-up basically, or being kicked off the receptor site from all the xenoestrogen and phytoestrogens in the air, that it's not acting to give us the benefits we need, which is the cognition benefits, the sexual benefits as a man. So ironically enough, most of men's sexual function and sex drive will come from their estrogen, not their testosterone. Testosterone is important, obviously, but estrogen has a lot to do with man's sex drives. I will preface or I'll conclude the video by saying that for me, injectable estrogen is a godsend to my life just for sexual functions.
And then also, too, just for mood cognition. Again, not that I was bad before, but for me, it just puts me in so much of a better place in my life. So just something to consider for all of you guys out there that are always looking to dial in your protocol. I'm not saying this is for everyone by any means like this. And probably if you're 30% body fat, should you inject estrogen? No, you should get down to under 50% of body. That should be your order. First order of priority is getting body fat off, because when you have too much bodyfat, that is the number one problem in your life. Unless you're injured, having too many body fats is a number problem.
So I'll say that. Check out Injectable Estrogen. If you guys like this video and want me to talk about this more, I will definitely put together a comprehensive slide. I just wanted to rattle off the dome, so I've been going down for 18 minutes, but thank you, guys, as I always conclude. The fact that I get to do what I do in the world now is the biggest dream come true for me. I cannot thank you guys enough for all of the support and everything on the channel, everyone that helps buy the products and Everything like that. So thank You guys so much. As always, the links are down in description and I will talk to you the next one. Peace.
