20 Fat Loss Compounds Ranked Worst to Best (No GLP-1s)

0:02 you Hey everybody. This is Hunter Williams. I hope you're doing amazing wherever you might be in the world. Today's video is going to be my tier list video of the non GLP one compounds for fat loss. So obviously the GLPs, particularly red, a true tide or the most powerful things that we have for FatLoss hands down, point blank period,

0:40 whether you love them or do you hate them? I don't know why you would hate him. No, some people do. But whether you love them or hate them, it is indisputable that the GLPs are the kings of fat loss. And obviously we're at a true tide being the king of kings when it comes to fat laws. However, there can be some things with the GOPs. One, we don't want to rely on those solely for fat law. So we obviously want a comprehensive hormone program before we ever put a GOP in place. At least that would be my opinion. We obviously want to have lifestyle dialed in, so we want our training dial it in.

1:14 We want a nutrition dial in we. Want our hydration dial and we wanna sleep out and all of those things will make a GLP work better. And once those are foundationally covered, we also want make sure that we have other things that were using as part of the program so that you don't have to rely solely on the GLPs. is my opinion that I think you should cyclically use GLPs. I don't think that you have to do the eight weeks on, eight week off like with a lot of peptides that do. However, I do think it is good to rotate through GLP's maybe where you're blasting cruising them to like where your taking it up in the dose and then coming

1:50 down on the dos and maybe even take a few months off out of the year. And right now I'm actually completely off of any GLPS I will probably go on another month or so to take two months of. But in the meantime, I thought it'd be a good idea because I'm using some of these compounds right now that are not GLPs to either assist with fat loss and help lean out for the summer. And so what I want to do today is just kind of give you options if GLP's are on the table for you or you're cycling off of a GLp or maybe you want use some these compound in conjunction with your GLP to help accelerate fat loss and also maybe not have to go on as high of a dose as a lot of people end

2:28 up doing. I see the most common mistake in the world today when we talk about peptides and GLPs is that people just use a GLp and then they escalate the dose to a point where they get really bad side effects and they have a lots of issues and lose muscle and all these things. And we talked about obviously hormones and lifestyle dialed in first. But then some of these other compounds, we don't have to rely in the same way that most normal people that are using GLPs rely on them. And so that's what we're going to do today. I'm going take 20 different compounds. Most of them are peptides. Some of the are not peptide, some are small molecules, but I am going review them, giving you my opinion on these.

3:04 These are like the exhaustive comprehensive lifts. There are many things that I left off the table, In the peptide world with the ones that we have access to, I kind of narrowed it down to around 20 different ones That we can use again either by themselves alongside a GLP or in an off cycle of a glp to really enhance fat loss And get us where we want to go from a body composition perspective If so, that's what we're gonna be talking about today. As always, before I jump into everything, thank you guys for being here.

3:36 Make sure you are on the email list. The link will always be down in the description. I've got one link now that you should be able to click on that will lead you to everything. You can download the peptide cheat sheet. you can get my links and sources to supplements and you could do all that good stuff. And obviously too, if you would like to ask me questions, The best place to do that is in the Axion Collective, my private group. It's $99 a month. You can cancel any time, but if you want your question answered by me, you can privately message me there. And then we do live coaching calls every Thursday night at 8 p.m. Eastern to where you talk with Taylor and myself and all the amazing other members of the group that come on the call.

4:08 So without further ado, I'm gonna share my screen. Today, we're gonna learn about these non-GLP-1 fat pounds, non GLP 1 fat loss compounds. We're going to a tier list. All right, let's get into it. The non-GLP one fat loss compounds tier list. I'm going to start with the worst and then we're going go to the best and this is going be F tier first. And when I say F here, I basically mean don't take these. Take these and the reason is the safety profile is not something I am willing to go. To I know there's lots of other people that do that and that's totally fine.

4:39 This is a judgment on those people. You should do what you want and you should research in the way you. Want to I personally just do not. necessarily plan to ever use these. So the first one is going to be adipotide or FTPP and I've never really talked about this and i've got a ton of people that have asked me to do videos and analysis of this, and maybe I'll do a deep dive on it one day to explain why I don't, but for the intents and purposes of, this is why i don''t.

5:09 Adipotide basically has the homing sequence that binds the prohibition on adipose endothelium. So it's a pro-apoptotic domain that triggers apoptosis, which is basically the death of cells, in this case fat cells. And so adepocytes die secondarily from ischemia once their blood supply collapses. That sounds really cool, right? We have an actual peptide that will go and target fat cells and kill those. Is that what we want? Maybe not. So there's strong preclinical data in obese mice and rhesus monkeys as to creating fat loss, which is really good.

5:39 However, phase one trial in an obese prostate cancer patient showed efficacy but also dose-dependent renal toxicity. So in obese prostate cancer patients, it did help get rid of some fat, but it also showed kidney toxicity. So the kidney proximal tubes concentrate the compound during clearance and take damage. And the mechanism has no off switch tied to fat mass. It ablates adipose vasculature regardless of how much fat remains. Basically what it is, is this lever that is creating The death of fat cells, but it's also called causing toxicity to the kidneys too,

6:13 which is why I personally choose not to use it. And when you look at it from a cost benefit analysis of like, what benefit are we going to get relative to some of the other agents that we have out there versus the cost to me, it is not worth it, so adipotype kills fat tissue by killing the blood vessels that feed it And so although that's an elegant mechanism, that sounds cool, the problem is the kidneys take damage at the same doses that produce fat loss. So again, this is why I personally choose not to use it. I'm sure, and I know that there's research companies out there selling that. That's totally fine. But that is what I, personally, choose to not do.

6:43 Again, do what you want to do, but that why choose, not too. Also on the F here is HEH fragment 176 through 191. Just to be clear, because I get asked this question all the time, This is not HGH. So a lot of people come to me and they're like, hey, I saw this HCH frag 176. Is this a HTH? Can I use this as HHH? It is absolutely not a HEH. It's a fragment of the amino acid sequence of HGH, but it's not HEA itself. And so this is very similar to AOD 9604. However, Aod 9 604 has this fragment with an added tyrosine for stability.

7:18 Aode is actually better than this. AoD isn't that great. I'll talk about that in a little bit. but this is actually even worse than AOD. And so there's less human data than a A O D and even the human day that we have is very weak. So again, I think if you're taking this, you just wasting your money. I would personally not use it if we're going to use one of them use AOT, but I wouldn't use HGH frag. Again, this not growth hormone. The only reason this even sells is because people actually think it's growth hormones or they think its going burn fat because they read on a description somewhere that that's what it does.

7:48 But in practice, it really doesn't do that at all. Those are the F tier moving along. Let's go to D tier. So these are ones that I would say are maybe have a use case, but the use cases very weak. The first is going to be AOD9604. Again, we just talked about that. It's a modified fragment of HGH. This one again has that tyrosine modification for stability. And so there is a little bit of data. So 12 week phase two trial, one milligram daily show 2.8 kilograms versus 0.80 kilograms of placebo for fat loss.

8:19 It was two kilos above placebo, for that loss and that's what gets cited. However, it's not really that meaningful. Again, when we talk about like over placebo what's that? two kilos would be like somewhere like four to five pounds. It's not that much more of weight loss versus placebo, especially when we have things like GLPs. And so I think if you're going to use this, it would just be something that you add on top of all the other things that are already doing. But I would never buy this by itself and use it by myself thinking that it's going create fat loss.

8:51 I've used it a ton. Maybe there's like an extra five to 10% benefit in addition to everything I'm already I would say the one thing that I think this could do well is if you are getting water retention from your growth hormone or growth-hormone peptides, it seems to lessen the water-retention. But I really don't think it's melting off that. And then the daily dose would be 250 to 500 micrograms. Obviously, you see here that they went up to one milligrams. Honestly, I've done 500 microns and one milligram, and it feels about the same there. So I'd think you could take five milligrams probably, but it is not going to do any much more.

9:25 some peptides seem to have like a threshold to which they reach to, which you're not really getting much more benefit. That was the D tier. So moving on to the C tier, that was only one I had in the d tier seat here. I would say these are definitely a use case, although I probably am not going to use them because there's going be better ones on the B, A and S tier or so. Sarah Morelin, people ask me, Hunter, why is Sarah morelin not on a cheat sheet? I actually just added it to a new, to do the new cheat cheat. It is on there. Basically is to GH peptide. That is just the weekend. so it's a GHRH growth hormone releasing hormone.

9:56 It's older, it's one of the first ones that we had. It was good when we have it, but again, there's just better things that have now. You want to do it 250 micrograms sub-q daily before bedtime. Uh, generally very well tolerated. A lot of people don't get any sort of weird reactions to it. I've, I'm seeing some people have reactions. But I just say it has been outclassed by Tessa, CJC and IPA. So those are just good for sleep. Good for helping with muscle, good fat loss. We have so many things are better. And that's why I would put it on this tier. Cause it is not bad, It's not great either.

10:27 The next one is B-set melanotide. This is a bit more of a rare peptide, but out of curiosity, a while back, I actually wanted to get some of this and try this. So basically it is an melanocortin receptor peptides, it's an MC4R agonist, so it restores satiety signaling in patients with deficient leptin-melanocorton pathway function. Basically this is, if you kind of think about the melanin, melanocortin peptides, which is like Melanotan, KPV, PT-141, that family of peptide.

11:02 Most of you guys, if you've taken those, you realize, or you'll know that you get some sort of appetite suppression when taking those peptides. Now, the appetite suppressant a lot of times is because you're a little nauseous. And so it gives you this like nausea, a tinge or edge that can create appetite depression. What they did with set melanotide is they took that and they applied it to that specific fragment of the peptide that causes that, and then use it as a peptid. And it actually has some pretty good human data. It's FDA approved for certain types of deficiencies and syndromes.

11:34 And phase three data shows 16 to 25% weight loss in those specific populations that have these genetic deficiencies. Now, I personally use this because I was looking on data. I'm like, wow, this could be an appetite suppressing peptide that helps with fat loss that works completely independent of the GLP. So if we were looking for something on the off cycle of GLPs, we could use that. and I took it and i took 250 micrograms and, I felt appetite suppression actually pretty good for like six hours and then around seven or eight hours in I,

12:07 took at the morning and later that day in the afternoon I started to get severely nauseous and it was like the worst melanotan nausea but even worse and Then it lasted for another one to two days and that finally went away and so I say this, meaning that it will absolutely suppress your appetite. But if you took the worst semaglutide feeling of just taking semoglutaride and that nausea feeling, it's like that, but even worse. And so that's why I don't recommend it. So for some people, that may work for me personally.

12:37 It didn't. The FDA approved dose is like two to three milligrams sub-q daily. I have no idea how people took that much because I took one-tenth of that and I felt that way. But I would just say that it's one of those things like proceed with caution if you're going to use that. It will suppress your appetite, but it will not be pleasant. So for that reason, I don't really ever recommend it to people unless they just have a glutton for punishment. I really want to do it. But you also can get skin hyperpigmentation as with some of the other melatonin peptides.

13:07 spontaneous penile erections in men, depression risk. And then I put severe nausea too, because that's something that I saw. But again, I think for people that have these specific genetic obesity syndromes that, have a melanocortin deficiency or something like that. It can work well, but for average people, it is probably not very useful whatsoever. Although I credit it, It will suppress your appetite. All right, moving on up to the B tier. And so we're going to get some better compounds here with some more evidence. Tessofencine.

13:38 I really, really like Tessofencene. Now Tessafencin, I remember taking Tissofencine, she was probably like 2021 when I first remember it. Back then, relative to what we had, It was really good. I mean, I love taking testofensine. For me, i get this cognitive benefit from taking it. So I feel more creative. i feel More in flow state.i feel much more focused, kind of like a nootropic, but it definitely does work to suppress appetite in some people.I will say it's a little bit more of a wild card in a sense that like 70% of people do well on it, Probably 10% of people feel nothing and then another 20% people

14:17 just do terrible. Meaning that it keeps them up at night, they feel anxious or nauseous or really bad and so probably like 20 percent of the people don't do well. But it's a triple monamine reuptake inhibitor so it works on serotonin, norepinephrine and dopamine. And it primarily suppresses appetite through dopamine and noradrenic. adrenergic effects, always mispronounce that word. It also increases resting energy expenditure and shifts substrate utilization toward fat oxidation. And so the dose is going to be 250 to 500 micrograms daily.

14:48 I've heard people going up to one milligram, but I think for me, I get really good benefits at 250 micro grams. More of the appetite suppression for me will kick in at 500 micrograms, but also too, that's where some people start to get the bad effects of sleeplessness and the blood pressure elevation. But a phase three trial in 372 Mexican obese patients showed that 0.5 milligram produced 8.6 kilograms of weight loss versus 1.9 kilograms placebo over 24 weeks.

15:18 It's approved in Mexico, pending in Argentina, and it's not approved you or the US, although you can get it Research places and some of the risks are heart rate and blood pressure, elevation, insomnia, dry mouth, anxiety, and you do want to watch your heartrate. So there is real weight loss. It is an oral weight-loss medication. I think it was originally studied for Parkinson's and then they noticed this weight lost effect and so they kind of shifted it over to that. But if you can't access GOP1s or for whatever reason, you don't do well on GOPs and you want something to suppress his appetite,

15:50 or you just want in your off-cycle GOPS, I think testo-fencine works really well. It's often forgotten now because of all these things that we have, but I would put it in the B tier. Next B tier is SS31. I wouldn't say SS 31 is a fat loss peptide per se. However, it does a lot to help in the way of creating an environment that is favorable for fat law. So I don't need to go too much into SS-31 from a mechanistic perspective. Think about SS 31 is addressing the hardware of your mitochondria. So if there is damage to your Mitochondria structurally, it is going to go in to repair that.

16:25 Whereas MOTC, which we'll talk about in a minute, works more as a software upgrade to mitochondrial to enhance what's going on from an energetic perspective. I would say the optimization dose of SS-31 is closer to like one to two milligrams per day. But if you do want to see more of a fat loss benefit, I will take it up to five to 10 milligrams a day and then stay there. And again, is that going to create fat loss directly? No, but it's going create an environment favorable in the body. And so that's why I even put this on here because typically people wouldn't get SS31 thinking that they're going get any fat lost at all.

16:58 However, just me personally, what I've seen is when we fix the mitochondria, that makes everything work better, including fatloss. SS 31 is so powerful at doing that. That's where I put it on. But it's generally very, very well tolerated. I think for the people that don't do well on MOTC or don' do with SLUPP332, SS31 is a great alternative. It just can get a little bit pricey if you're doing those higher doses that I thing people are going to see bigger benefit at. And I've heard doctors tell me personally that you can go up to 20 milligrams per day, even for a healthy person and get really good benefit.

17:29 So again, that becomes cost prohibitive for lot of people, but I thik beneficial nonetheless. The next B tier is going to be coagulantide cagri, as it is affectionately known in our world. So what is coaguilentide? It's a long acting amylin analog, so basically it works to suppress appetite, again, independent of GLP, slows gastric emptying, suppresses glucagon, and acts centrally on satiety through the area post-tremor. And it's a different mechanism. So it is synergistic, not redundant.

17:59 And some of the key risks are GI side effects similar to GLP-1s, but milder so people can get nausea, constipation. It's weird because I don't see this as much clinically like when you research this, But in practice, I start to see it a lot. I would say like almost half of people that take it get severe depression or emotional blunting or anhedonia. And so I would say that is the major risk. Like I do very, very well on coagulantide. It is a perfect alternative to a GLP for appetite suppression for me. But my wife, Taylor, does terrible and she feels terrible.

18:33 She feels depressed and sad and everything when she takes it, so she doesn't take it. And so I think it's just one of those things is kind of a coin flip, whether it is going to work for you or not. When we look at the evidence base in clinical trials, when people took coagulantide with semaglutide, they had 20.4% weight loss in 68 weeks, which outperformed semoglutaride alone. And then standalone on its own, so without semiglutaide just Cagri alone, there was 10 to 11% loss at higher doses. is one of those things I think is very close to becoming FDA approved.

19:06 And so we'll likely see that push more once it becomes FDA-approved as an alternative to GLPs or something that people stack with GLPS. I would say the dosing, everyone should start with 250 micrograms or less, and then titrate up there. Some people need to get up to three to four milligrams before they really notice the appetite suppression. But for me, if I take 250 to 500 micro grams per week, It is perfect. Like the appetite suppression is great. I don't get hungry. And to me, the Appetite Suppression is a little bit more mental than it is physical.

19:38 The GLPs, you really feel the apptite suppression kind of like in your gut and it fills up. Whereas this feels like more like your brain is shutting down, like, Hey, I'm hungry, and I dont need this anymore. I'm a big fan of it, but I put it on the B tier because itself by itself, it doesn't really create that much fat loss. It really just suppresses your appetite. And so I would say it's one of those things. If you don't get enough appetite suppression out of your GLP, But you. Don't want to increase the dose. You can pair it with this. Or if you want something in your off cycle to help with appetite, suppression, It's going to work there.

20:08 But I, I wouldn't cap it at a B-tier just because, uh, Another one on beats here is IGF-1-LR3. I don't really view this as a fat loss tool, but I do view it as body recomp tool. So again, this is going to be one of those ones that is more of like a muscle building peptide. However, I will say it does help with recomposition. And so you're trying to put on muscle and burn fat at the same time. You can use this alongside of HGH or your HGH peptides to enhance results to potentially make you more lean.

20:47 I would start pretty low, 25 micrograms injected into the muscle that you trained pre or post workout or both. And then you can go up, for instance, like I'll go out to like 100 micro grams and then sometimes 200 micro-gram as I'm going through that four to six week cycle and my body acclimates to it. The one thing you have to do be careful of with this is hypoglycemia risk. So you just want to make sure that have carbs on hand. If you're insulin sensitive, this can be very analogous to taking insulin and it can drop your blood sugar. or lightheaded and you don't want to pass out from having hypoglycemia.

21:20 So just be aware of that. Just have some carbs or some candy without fat on hand to help bring your blood sugar back up if that happens to you. But I always take this with 20 to 30 grams of carbs to make sure that I am stable. And if you do that, you'll be fine. Um, but it definitely is more of like a body recomp tool, much more than it is a fat loss tool. I think it can be useful for people that want the tone up and shape up. That would be why I put it at a B tier, B tier, last one is Carterine, so GW501516.

21:51 I debated whether or not to put this one on A tier or B-tier, but relative to what we have on the A-Tier, I was like, this is probably a B Tier. And so it's a selective PPA or agonist that drives a metabolic shift toward fatty acid oxidation, improves endurance, lowers triglycerides and raises HDL. Short-term phase two trials showed lipid and endurance improvements and the dose is usually 10 to 20 milligrams per day. I think 10 milligrams a day does great. i love carterine, i wouldn't say there's like a ton of fat loss but it enhances your cardio so much that i think you get a fat-loss benefit from it.

22:24 And so if you were to just take it and not do anything i don't think, you're really going to burn that much more fat. But if you take it and you do cardio, I think you get more bang for your buck out of the cardio based on what it's doing in terms of metabolic flexibility and shifting how we burn fuel toward fatty acid oxidation. And again, it was stopped because there were trials in the mice that showed that mice got cancer. eliminates cancer and there are studies that show that it causes cancer. And my, so it's just one of those ones when we want to be careful with, I just stick to around a 10 milligram dose.

22:56 I know some people go higher to like 20 to 25 milligrams, but for me, get really good benefits out of 10 milligrams. So I cycle it for four to eight weeks at a time. As long as you're cycling cycling it, there's nothing to worry about. When we look at the safety issue, There's another similar product called GW0742 that I really like as well. It probably has an enhanced therapeutic effect beyond Carterine. but Carterine is still great. I still love it. It's just not one of those things that is going to necessarily like melt fat off your body, but it really improves cardio to which I think has the indirect effect.

23:29 So that's why I put it at BG. Now, let's move on to A tier. This is where we get much more into the ones that we see. A lot of real world clinical data to back up, but then also to just in the research world that were all in that I see do really well. The first one's going to be CJC, Nodac, and Impramilin. And I know this is not necessarily a fat loss peptide, again, to go to the benefits that it creates within the body, it really does help with fat-loss because of everything that's doing. It's gonna improve sleep. obviously IGF-1 levels, GH in the body, which is then going to have the downstream effect.

24:02 And what I love about it is for most people, I know some people have a bad reaction to the CJC, but for many people they handle this really well and get really good results. It's not going be growth hormone, it's even not gonna be Tessamerelin, But there are good result. So you could do 150 micrograms of CJ and IPA, you can do 300 to 100 of IP to CJ. It really is up to you how you decide to combine them. I know most blends come in like a one-to-one mix or a three- to- one mix, so I put both on there. Now you might get a little water retention, injection site flushing, and occasional sleep disruption.

24:34 If you do get the sleep disruptor, I would move it to the morning. But again, when we look at body composition, this does really well. It's a great entry for people into the growth hormone class of peptides.I would recommend if you've never tried these to use them in isolation first. to see how well you do. And then if you well on IPPA and you're doing well in CJC, then go ahead and combine them together. Because some people really don't do well with CJT. They have immune reactions, they get the flushing, and they can't handle it. So sometimes they just need to stick to epimerelin. But some do great on CJS and can combine these together and do it well.

25:08 Obviously you get a lot of what GH gives you at a fraction of cost and it does well. So I like it. This is probably one of the ones that is a little bit more controversial. Should you put on A tier or B tier? I kind of thought, and I was like, well, I think for all the other benefits that we're getting on top of fat loss, The next A tier is MATC. I would say like CJC and IPA is like an A minus, whereas MAT-C is going to be closer to like in A or an a plus. So in the A-tier, I'll distinguish between like a minus a and a-plus.

25:38 MATCI obviously a mitochondrial peptide, improves fatty acid oxidation, glucose uptake and insulin sensitivity. It also is an exercise mimetic, so it basically is signaling to the body a state of exercise. I personally prefer the protocol of one to two milligrams subcutaneously daily. Like that five days on, two days off, and then run for eight weeks on and eight week off. There's a lot of debate on the dosing for Matzi. Some people like to get into the five to 10 milligram per dose range. If that works for you, totally cool. With that, I just personally can't do it.

26:10 I started using MOTC a few weeks ago and I took one milligram with one milligrams of five amino. And I literally had so much energy. I felt like a child, I've felt a seven-year-old that was being told to sit down in class. That's how much of energy I had, which is a good thing, but it also sometimes it can be a little annoying to have that much because you feel like you just got to go work out. You can't sit out and work. So I do really well at that one-milligram-per-day dose. But I know some people need the higher doses. This is really, it's variable to the person and dependent on the.

26:42 But, I would start there and then see where you go. I think when we get into the high dosing, that's where we see more bad reactions that people have with the anaphylaxis. Personally, would get pretty hypoglycemic if I took that much and could get dizzy and lightheaded if i don't have enough carbs. I will say though, over time, Matzi is great for fat loss and great because of what it does. It doesn't burn fat directly, but it enables your mitochondria to work really well, which will then burn that. And so for that, I would lean towards saying like Matz is on like the A plus side.

27:13 Next one, five-amino. I would say AA plus for five amino. It's an NNMT inhibitor, which basically just means that it raises endogenous intracellular NAD in the body. So it creates a metabolic break that makes fat cells resistant to lipolysis, and it restores NID plus in adipocytes and reverses metabolic dysfunction directly in fat-cells, not through appetite or GH signaling. Some people do get appetite suppression, but this one's really gonna be more directly on burning fat. You could use the oral.

27:43 I don't think the world works that well, but the injectable works really well. Especially if you pair it with MOTC mouse studies show 30 to 40% reduction in fat cell size without changes in food take. And we don' have any human trials that exist yet, This one, I know it works and I've used it and it worked. I think especially as people get leaner, this is one of those ones that can help you continue to get leaner. Obviously dose dependent. If you're using it, would just be cautious that if you were going to do higher doses of the injectable, like five, 10, 15 milligrams per day,

28:15 just to be conscious that I have seen kind of a blowback on that to like where it's inducing so much of this that it kind feels like burning out. And I like one to two milligrams injected per day. I would even start with maybe 0.5 milligrams, work your way up to one milligram. Then if you do well and you want to experiment, go up. But for me, if I go over two milligram per today, really again, I start to get that burnout feeling. There's too much energy and I feel very much like I'm being pushed into metabolic fatigue or burnout when I do that. And so I don't go for that dose, but at those doses, it works great.

28:48 Again, the oral 50 to 150 milligrams daily oral, But if the injectable one or two Sub-Q or IM works great. You can do it eight to 12 weeks on, four weeks off. But I love five amino, I would probably say, if you have matzi and five-amino together, that's an A plus. Another A tier, this one is like A minus to A is going to be BAM 15. And the reason is because of the mechanism, it is a mitochondrial encoupler. Now what that means is that it increases proton permeability across the inner mitochondria membrane, which dissipates the proton gradient.

29:23 The cell burns more fuel to maintain ATP and energy is dissipated as heat. And unlike DNP, BAM-15 has a wider therapeutic window and doesn't cause respiratory collapse. High doses in animal models is structurally different and behaves differently, but human safety pharmacology really hasn't been published or studied. There is a lot of rodent data around the benefits of this. Body fat reduction without appetite suppression, no lean mass loss, glucose tolerance improvements. And there was a study where they compared BAM15, I think, to semaglutide enters appetite in mice, and it outperformed the fat loss without any lean-mass loss.

30:01 Which is pretty, pretty crazy. I think it's just one of those things like the dosing, I would say to be conservative, use like 50 to 100 milligrams per day. And anything that goes up higher than that, if you get into like four to 500 milligrams a day, i've just seen kind of diminishing returns at those higher doses. But I think for eight weeks, if you're using it like 100 milligrams per day, it works really well. I'm not someone that tells people you can or can't use this with SLU. If you want to use it in isolation, use in an isolation. i've used it with slu and it's worked great for me, but for some people that might not be the thing.

30:34 And so I thinking at this point, when we talk about that debate, It's really just theoretical. We don't have any data to go off of. But it is interesting to say like, is it better in Isolation? I definitely think you use It in a isolation and get great results. That leads me to my next one. I would say SLU PP332, I'm going to classify more like on the A plus side. So again, it's an estrogen related receptor agonist. Estrogen related receptors are highly expressed in skeletal muscle and brown fat and the activation of those drives mitochondrial biogenesis,

31:09 fatty acid oxidation, and oxidative metabolism. and the genetic program that endurance exercise activates is done through that. And so this would be the most studied exercise medic of this class. The mouse data is really strong. Human clinical trials have not started, although I've heard that that's something that is being done and likely will be done. The dose, this again is probably where more of the controversy is, like should you do high dose? Should you low dose. I like the 250 to 750 micrograms per day for eight to 12 weeks on and four weeks off.

31:39 For me, I genuinely notice that. And notice more energy and more fat loss at those doses, but I don't get the metabolic fatigue or burnout. 20 milligrams I've done, a hundred milligrams, I have done 500 milligrams. When I do those higher doses I just don't feel as good and thus I did the lower doses. So it works great. I love this. And again, this is one of those ones I think when we talk about like five amino, Matzi, BAM15, SLU, it definitely sits right there. and I would say it's like as, good if not the best out of all those.

32:11 There's a debate right now of the injection one. It does fine orally. What I would be willing to try is this suspended in oil because it seems like the one suspended oil is the best way to deliver it via an injection. Now, how much better is that over the oral? I don't know. I've used transdermal version of this before and it worked really well, but I know how better the injection is. oral, I would say the transdermal is as good or maybe even a little bit better than the oral. And so they all work well. But I love SLU is definitely a good one.

32:43 I think, especially for people that are active in exercise, this is one of those ones that really enhances exercise performance, improves all the markers around like whether it's performance or longevity at the right dose. We're seeing a lot of good things. Also an ATR, I debate whether this is better than SLU and I would say I'd maybe give a slight edge to this because I've used it at higher doses and that's going to be ATX304. Some places sell this as OS01 but this a pan-AMPK activator so it activates AMPK in muscle, liver and fat without crossing the blood brain barrier where

33:20 AMPk activation can drive food intake. So it produces increased energy expenditure and improved glucose handling without appetite reduction. We actually do have human data on this and maybe that's why I would give this one the slight edge because it has been studied in humans. It actually was looked at over four weeks and everything improved. There was no downsides that I looked that in the small human trials. And it's actually being evaluated as a post-semaglutide maintenance tool because, it helps with fat loss and also does not decrease muscle mass like semagglutides or the GLPs do in trials, In the trials, they were using 1000 milligrams per day, which I think becomes cost prohibitive for a lot of people.

33:56 So that's why it's just off the table for many people, I've gotten really good results at 300 to 500 milligrams a day. Really good energy, really fat loss. This also helps with like water retention. It keeps water off you. I notice I'm much drier when I use this, Which is good if you're getting ready for photo shoot or something. And again, Pan-AMPK activation has broad tissue effects. So I think as we see things move forward, this will be one of those ones that comes in as an adjunct to GLPs or maybe a substitute for GLP.

34:26 But I love this. It's just one those one's not a lot of people have used it because of how expensive it is at the right doses, but I loved ATX. I would call this actually a solid A plus. And what I like, you know, with everything we have now, we can kind of rotate from ATX to SLU to BAM15 to MATC to five amino and kind of go in this merry-go-round like where we're using different pathways to create bat loss to get really good results. And I would put this up there with those. ATR, another one, Mirabegron, this is much less known about, but I think it's really cool and not a lot of people know what it does.

34:59 So it is a selective beta-3 anginergic agonist, and beta 3 receptors are concentrated in brown and beige adipose tissue. The activation of brown adepose tissues, thermogenesis through UCP-1, increases lipolysis in white fat and improves insulin sensitivity. And so beta three selectivity minimizes cardiac and vascular activation at therapeutic doses. And, so it was actually a drug developed for overactive bladder and people would use 25 to 50 milligrams a day for an over active bladder. But for body comp protocols, we look at like 50 to 100 milligrams per day.

35:31 And so it's FDA approved for the bladder, but they noticed that there's fat loss. There was a four week study at 100 milligrams that increased brown adipose thermogenesis activity, improved insulin sensitivity, and raised HDL. 12 week studies at 50 milligrams, no effect on a body weight or fat mass, But the higher doses at 200 milligrams activate brown adipose thermogenesis more meaningfully, but raise cardiovascular concerns and lose beta-3 selectivity. So as you go up in dose, and this is where you have to be careful, you can become tachycardic, get high blood pressure or urinary retention.

36:07 Again, because it's an overactive bladder medication, uh, So it improves metabolic health markers more reliably than it moves the scale. And so in trials, we don't see that much weight loss, but I think for the person that is training and doing cardio regularly, you will see it. It works really well. I kind of think about it as similar to an albuterol, not as strong, still doing a lot of the same thing. It's not going to replace the GLP-1, but I think for people that are competing or really trying to get diced, you can use it for like two to four weeks

36:39 to help dial that in. But beyond that, You just too have to be careful about increasing heart rate, especially if we're talking about like mixing with all these other things like erythritide, like MOTC and 5-amino and SLU. If you're combining it with those things, just be carefull because it can be done. Albuterol is going be a beta-2, whereas merbegaron is gonna be beta 3. So you could use that to kind of like enhance the albuteral effect. Now on to the S tier, what you guys have all been waiting for. So what are the STR ones?

37:09 And am I going to be right or are you going guys going disagree? We'll find out. But speaking of albuterol, albuteril does not get talked about that much, but man, every time I use al buterul, the results are undeniable. Only thing I would say it's like S minus, meaning that I was caught on the lower end of the S tier, but above the A plus tier is because it only works for a couple of weeks and then you have to cycle off because you just build up a tolerance to it really fast. So it a beta two receptor activation in adipose tissue that increases cyclic AMP, activates hormone sensitive lipase and drives lipolysis.

37:43 Beta two activation and skeletal muscle has a mild anabolic effect, making albuterol more lean mass sparing than clenbuteral. or non-selective beta agonist. And I like it too, because you don't have a lot of the downsides with clen that you do with albuterol. It's just that clent is kind of entrenched in the bodybuilding world. So it's seen as a fat loss agent there and it works. I just think albuterol is better without the side effects. it also increases resting energy expenditure around three to 5%. So think about that if you're burning, you know, 3000 calories per day and you are increasing

38:14 that by 5%, what would that be another 150 calories that your burning? So it's FDA approved for asthma since 1981. Decades of pharmacology data that's relatively safe and the body recomp effects are well documented in clinical and athletic literature. What I would do is you can get a liquid tincture of these from most research places. Two to five milligrams per day orally is what I recommend and cycle two weeks on, two week off. Beta two receptor down regulation begins within two to three weeks, blunting the fat loss effects. So what's crazy is like you'll take this, you know, You could start at two milligrams per day orally.

38:44 And then like in the first few days you're like, Oh my goodness, like I'm getting so lean. I've doing my cardio, my Cardio is easy and I am getting lean and then after a couple of weeks it just starts to go away. That's why I would say two weeks on two, weeks off is the best thing to do. You can really do that throughout the year. so you could have, two-weeks on, Two-Weeks off and do That pretty much every month. However, just be advised can cause tachycardia, tremor, anxiety, sleep disruption, blood pressure elevation, and hypokalemia with chronic use. So it's not appropriate for people to have arrhythmias, uncontrolled blood, pressure, or ischemic heart disease.

39:15 Again, be careful. This is one of those things you can take in the morning. If you take too much, you're going to be shaking the rest of the day. Also too, I've injected albuterol before. with yohimbine and be very careful because the injectable dose you're obviously absorbing more and so if you inject two milligrams of albuterol you are going to be on fire. Just be cautious that you were going like start to feel tachycardic because of that and it will go away after a few minutes but that does happen so just be aware of. That I would say the injected dose is closer to like 0.5 milligrams would be the most that I want to do at one time based on my experience but Albuterol

39:49 works great. Again, it's one of the best things, so documented for fat loss. So many people just don't really know about it, and I would categorize it as S-tier, but there's going to be some better things. So the next one is going to be HGH. I love HTH. HHH is the most underrated when it comes to fat loss. Again, it's not necessarily a fat-loss compound, but we're getting direct GH receptor activation and lipolysis through hormone-sensitive lipase upregulation, increased fatty acid oxidation, reduced glucose uptake in adipose tissue, and it drives IGF-1 production from the liver.

40:24 There's decades of human data. It's FDA approved for adult GH deficiency, obviously a lot of other things too. And in GH deficient adults, we see around a four to seven kilo fat mass reduction and two to five kilo lean mass increase over six to 12 months. And non-deficient adult's data is murkier, but I would say at this point, most people in their 40s, 50s and 60s probably have a GH deficiency. For body comp purposes, one to three, I use daily work really well. I think for IUs and under, it's really going to be like more of the fat loss.

40:56 I'm not saying you can't get great fat lost at higher doses, but you're just going increase water retention, insulin resistance, carpal tunnel, joint pain. And so you got to really know what you are doing to work your way up to those doses. But I thing for most people, one to four Ius is going be great for fatloss. This is not going one of those ones. It's not gonna get you shredded in like two weeks. If you look over a period of two years for someone using growth hormone, anatomically speaking, the body just transforms so much when using growth hormone. And for that, I call it absolutely S tier.

41:27 Some people may disagree with me and that's okay, but just in my own life, Then obviously, Tessamerelin. I personally don't really use Testamerelin that much because I use growth hormone. However, I think for people using peptides, when we talk about a non-GLP fat loss, data wise, this is as good as it gets. So it's a GHRH, a stimulates pituitary GH release and pulsatile physiologic pattern. It works on downstream IGF-1 elevation and direct GH effects, produce visceral fat reduction without the supraphysiologic exposure of exogenous GH at higher doses.

42:04 The dosing is to be one to two milligrams sub-Q daily, five days on, two days off, and you can cycle for eight to 16 weeks and then take four to eight weeks off. Again, just monitor your blood sugar. I know most people, if you're eating right, training properly, you are not going to have any issues with blood sugar. But phase three data in HIV patients with lipodystrophy, it showed around 15% visceral fat reduction over six months and lean mass is preserved or slightly increased. This is the only non-GLP-1 fat loss peptide with phase 3 human data and FDA approval and brand new weekly formulations as of last year.

42:38 So I guess now there's a weekly formulation of Tessmerolin that you can do weekly. Now, I don't know if I would want that per se because I like the pulsatile fashion of it. I do not know pharmacokinetically how those work yet. But I would say testosterone from a data standpoint and also just a practice standpoint is the gold standard. The only caveat I'll say to that is like, let's say a guy's like eight or 9% body fat and he wants to get down to five, testosterone is not really going to make you look aesthetically that much better because of the water retention.

43:08 However, if a guy's like 25% body fat and wants to get down to 15% Body Fat, Tessamrelin will work so, so well for him because he's not going to notice the water retention that's coming. He's just going see the fat loss. And so I will caveat saying like if you're already pretty lean and you trying to even leaner, it won't look like you're getting that much leaner. And then when you use it and come off, you'll notice that you are lean. But I think for those people that are too heavy or too, or heavier than they want to be, like in that 25 ish percent body fat range for a man,

43:40 and you try to get down to like 12 to 15, it's going to work amazingly well for that. So that's why I would say it is S-tier, the best that we have. S tier plus for Tessa Morellen, And again, even though I don't personally use it that much, I will throw it in every now and then because I use HGH I think for people that don' want to use HEH. Or again if you're in that category of like your 25% body fat as a man or 35% as woman and you want get down like another 10 to 15% Body Fat, Testimone is going to work really, really well for those people. And I would say even probably, probably better and faster than HE.

44:13 And that's why I would call it a little bit higher than HEH, whereas HEh is going to just be more for someone that is optimized like consistently year after year better. Test run is gonna be of that like short term acting one that it's gonna work. So that' it. And so there's the summary table. I'll leave that up just for a second. If you want to screenshot that with all the ones on there and go and obviously to remember if you are in the private group, you always get access to the slides that you can download.

44:43 That is it for the slides. And that is my non GLP one fat loss tier list. Man, that's a mouthful. Say that five times fast, but hopefully that was helpful to you guys. I know there probably will be some disagreement and that totally okay. you think should be lower. It's okay to disagree with some of these things. I think as this movement progresses, it's really good to have discussions about these and really kind of drive the research,

45:15 at least in our world, forward about what is Accepted what is common and kind of like what? Is the best practice for these things? So this is my best attempt and obviously too I'm sure there are ones that I didn't think of that. I left off of this list that could have been included and that's totally okay I realized there's some great fat loss agents out there But for the purposes of time and making this a video that easy to digest These are the ones I came up with so thank you guys so much just in closing I just always want you to know I am so so grateful for all the support I get I always have the Best audience in the world because I do and to get to do what I do is a dream come true.

45:49 So I want you to know that, and know whatever shape, form, or fashion it is that you support me, whether it's using my code of places, sharing this with friends and family, obviously being on the email list and being in my private group. Thank you. I just want guys to that know you are appreciated, you're loved. And as long as you guys keep supporting me I will keep doing this. But thank you, guys, so much. Would love to hear your thoughts and feedback. Without anything else, I think I'll shut this one down. Let me know your thought and I talk to you in the next one. Peace.