These Peptides Are Overrated (Here's What Actually Works)

0:00 Hey, right. This is Hunter Williams. I hope you're doing amazing wherever you might be in the world today, I have a little bit of an interesting one. Um, you know, one of the most common questions that I never would have guessed that receive or would receive is about what peptides actually hate. And now that think about it, it's actually like a very common question to ask is like, Hey if you talk about peptide, tell me which ones you don't like because I'm spending money on these things and it actually might not be the best use of my money nor would it be What I'm going to do today is I actually going talk about the five most overrated peptides according to me.

0:32 And when I say according me, I don't put these on these lists to say that there's not a use case for these peptide because there actually is a used case. I think for everything that's out there, it just might not be for me but. When you look at peptides, there's quite a few peptide out there that I would say are probably only relevant for maybe like five to 10% of the people that actually buy them. And the other 90% are actually just getting something that probably has a better substitute that they could use really for the same price to get way better effect.

1:03 And so, in making this list, I don't say this to tell you that someone can't get results from these peptides, because you obviously can. I do not say to say that, hey, if you like these, peptide, don not use them. Or even these there is not really any safety issues with using these. Although I could probably do another video that is the top five peptids not to use because of safety issue. All the ones I am going to talk about today are relatively safe, at least in terms of peptidies and are safe as any of the others. of peptides out there. So that's what we're going to talk about today. I think you'll find it pretty entertaining.

1:33 And I had fun putting this one together, but it's kind of funny because I have all these questions that I aggregate and then use language models to help me decipher. Cause I get so many questions of like, what is the most common ones and the the common one or not the, most come in one, one of the one most commonly ones or with someone telling me what peptide or they want me to make a video about what pep has they don't like. That's we are going do today, I, think it should be really exciting. Before I jump into that, just wanna say thank you guys to all the overwhelming and amazing amount of support I've been receiving lately.

2:03 The best place to stay in touch with me is on the email list in case I get censored from any other platforms. So the link will always be in the description of the video to sign up for the Email List. You can just Google Hunter Williams Email list signup and it will come up if you don't wanna do that. There's a lot of times people are like, hey, where do I go? If you just google Hunter William's sign-up for Email Lists or Hunter Williams Peptide Cheat Sheet, it should come and you can opt into the Cheatsheet or you could sign The email list, and also too, if you want to have direct access to me, to be able to message me and come on live coaching calls with me on Thursday nights at 8 p.m. Eastern, the best place to do that is the Axion Collective.

2:35 My wife Taylor and I help run that group and it I think is best group out there. And we have a lot of really amazing people and not just for us, but for the amazing in there, I it's worth the cost of admission. So check that out. But without further ado, i'm going to share my screen and today we're going talk about the five most overrated All right, let's get into it. The five most overrated peptides. None of these are really that dangerous, but I do want to say that they're probably not, or they, they are not dangerous but they were probably at least on the spectrum of worthless.

3:05 So I get asked again, what peptide are the most beneficial almost every week. And let me be clear about what this is and what it's not. It's a hit piece. Every peptid on this has legitimate research behind it and I think a legitimate use case is just for me personally. They're not ones that I would use. The problem is that the peptides either don't work well enough at real world doses, or they have just, and I think this is more or less like what we're dealing with with most of these, they've just been surpassed by other better compounds. So dollar for dollar, milligram for milligram, we have other compounds that we are going to talk about today, but old habits die hard,

3:41 as they say. And it's one of those things, like a lot of people know these are out there and they just feel comfortable with them. Let's talk the first one. Number one is going be AOD9604. Now I say this again, I've used AOD 9604. I don't even necessarily dislike Aod 9 604, but I will say it is probably the most number one overrated peptide. And in case you're unfamiliar with it, AOD is a modified fragment of human growth hormone, which is the amino acids 177 through 191. So basically growth hormones is 192 amino acid long, and we can splice those amino assets up into the segments of 172 to 193. We get this peptides called A O D.

4:17 is originally designed to isolate HGH's fat-burning effect without the growth-promoting or metabolic complications that come from full-length growth hormone. Sounds really cool on paper, right? Let's modify growth hormones, only take the fat burning benefits from it without blood sugar effect or anything like that, so that we can ramp up the burning without having some of those other downstream issues. However, it never panned out that way. Metabolic Pharmaceuticals ran a large phase 2B trial with over 500 participants on this and results were very underwhelming to say the least,

4:48 statistically significant but barely noticeable fat loss and the company ultimately abandoned the program as many people do abandon AOD when they start using it because they realize it doesn't do that much for fatloss. Pharmaceutical companies don't walk away from compounds that work, obviously. And then AOD 9604 also has a very short half-life and dosing protocol, likely never optimized. So again, because of the half life, you probably need to dose it two or three times a day to really see the effect, which again just becomes not even cost prohibitive, but just lifestyle prohibitve because Of the nature of having to do that.

5:19 I will say I've taken this as high as one milligram per day. A lot of people only do like 200 micrograms to 300 micro grams and I have done it as But I see it as something that if you're doing a GLP and you are doing GH peptide or HGH and your doing metabolic peptides or a mitochondrial peptid like MOTC or SS31, then you can throw this on top of that and maybe you get like an extra 5% boost on what you already doing. But if your just going to inject AOD without any of those things, I'm just being honest with you, it's probably not going much.

5:52 And so that would be my thing is like, I don't think it works that well. Now, what would I use instead? I would use tessamerelin and or a GLP-1 agonist. So if the goal is targeted fat loss, tesamerelin is a far stronger option. You know, there's clinical data showing 15 to 18% reductions in trunk fat for over 26 weeks and for overall fat loss, GLP1 receptors are obviously the gold standard. And so when we look at AOD, there's just not a lot of clinical evidence. There's not lot a of, I would say, anecdotal research evidence, and then if we use Tessamerelin plus a GLT, we're gonna get so much better.

6:31 Then when look the amount of money that we would also spend on those, especially if you're sourcing in the research world, it's gonna be so better to use those rather than to So those would be my alternatives to AOD. The next one is going to be GHRP2 and GHRP6. Basically, these were early synthetic GH secretagogues from the ghrelin mimetics. So these are GH RPS, as the name implies. They bind the Ghrelins receptor in the pituitary to stimulate growth hormone release.

7:01 And they were popular in early peptide communities for being cheap and accessible. I will say that they do their job. However, this is where they fall short. GHRP6 can cause ravenous near uncontrollable hunger within 15 to 20 minutes of injection, which is obviously counterproductive to us that are trying to maintain body composition. It also significantly elevates prolactin and cortisol. GHRB2 is a little bit better, but it still raises cortisol meaningfully. And both ghrelin receptor desensitization with chronic use requires dose escalation over time, Which is again, a fundamental design flaw in those.

7:36 So again I will say, The use case for these would be if you have someone that is struggling to eat, and if they're struggling, to put on weight and are struggling. To eat these can be beneficial if. You just take them right before a meal because they are so short acting. That would. Be the one case where I would say it would, be. Beneficial is if, you. Have someone, that doesn't have an appetite you could inject this and then they. Are going to have. An appetite and. Then they would eat. But most people have the opposite problem. They eat too much. And so if you use these, yeah, you're going to get a good GH pulse, but you'll basically rage your pantry.

8:10 So they're not good. Then what would I try instead? We have ipomerelin, which has all the benefits of the GHRP on the pituitary via ghrelin. But we don't get the prolactin and cortisol increase, and we get to increase in appetite for most And then when we do the Ipamerelin, we could pair that with CJC to get the full spectrum to have the growth hormone releasing hormone component. And that would do CJT no DAC. So we look at the GH release, it's stronger and more sustained with Ippamerelin and CJ. There's mineral to no hunger, there's negligible effects on cortisol and prolactin.

8:44 Then again, the selectivity is a little bit better. or iparamellan CJC, they're just going to be better at everything. And I would say the case for GHRP2 or 6 would really just to help someone to eat more if they are really struggling to. The next one, very similar to AOD, and I would say even worse than Aod, is HGH FRAG 176 through 191. So we talked about AOD being 177 through 197, HGFRA is 175 through 196. This is the unmodified C-terminal fragment of human growth hormone, essentially A O D without the tyrosine modification and it's positioned

9:22 as the pure fat burning H G H fragment. Again, I would even say it's worse than AOD. And for some reason, people are still buying it and people who are out there selling it. But everything wrong with Aod applies here, but it is actually worse. So Aody at least had clinical trials, HG8 does not, and there's almost no human clinical data. It's just one of those things that it Aode but worse, so if you were going to use one, one these I wouldn't use HGHFRAG Um, fortunately, I don't get that many questions about that one, but I was just coming through when I was preparing this video,

9:53 was coming to research sites and I'm like, man, people are still using this and buying it. Obviously some people aren't because it's across a lot of research. And I think people just see that they Google it and they're like Oh, fat burning. and then they get it. But again, this would be one that is not on the peptide cheat sheet and not one I talk about. So what I try instead, I think when we look at the growth hormone component of fat burning, tessameralin is going to be the strongest. Very similar to what we talked about with AOD, meaning the tesserallin and the GLP.

10:26 option. And then next, I would say this one is actually probably much more of the controversial take on this. This is going to be Ceramorelin. So Ceramellin is a GHRH analog. It was the first 29 amino acids of a 44 amino acid GHH molecule. Became FDA approved in 1997, and it was most commonly prescribed to GH2-Criticog in anti-aging and longevity clinics. But As it stands now, we have things that are so much better than ceremerelin. Now, I will concede that cemereline does work for some people, but those people have never used any of the other growth hormone peptides or even touched

11:04 growth hormones itself. And so if you take someone from zero and you give them ceremorelin, it will be better that nothing. So I would conceded that. However, my question is, why would you use it if You have these other better ones that are really the same price and in some cases even cheaper than Sarah Morell. And so it does stimulate GH release and has clinical data, but it has a very short half-life and it produces a brief relatively weak GH pulse. Many users report underwhelming results even after months of consistent use. It also appears to lose efficacy over time and Sarah morellin was groundbreaking in the nineties, But we have better tools now and I will say I think the

11:40 reason that this one still persists is because it was FDA approved at one point and And so technically clinics like are not going to get in trouble for writing a prescription for it. And, so they feel good about it and all the people out there that are, I will say, less aware are like, oh yeah, that's going increase my GH. Give me that. It's pretty cheap and there's probably a little bit of placebo effect. But again, I will say it probably does work for some people, but I just think like, again relative to what we have access to, why would you use it? I don't know at this point. Again, especially in this case, because they're not going to be as strong as Tessamerelin, CJC Nodak and Ipermorelin.

12:15 Pretty much in every area, they're going to be superior, better GH pulse, um, Better long term, long-term efficacy. Cymerelin seems to, uh, see people desensitize to it pretty fast. Um, and then the mechanism we get the GHRH and the GRHRP with IPA and CJC, whereas CYMERELIN is just a GH R H. And I would say CJC would be like vastly superior. CJCs, no DAC particularly, would vastly be superior to Sanmorelin. They're basically the same type of compound, but CJS is just better at doing what it does and better with the growth hormone pulse and actually having

12:54 real world tangible benefits. So again, I'd say, hey guys, it's 2026. If you like San morelin, nothing against you. It's just relative to the cost is going to be the Now the last one is actually going to be five amino one MQ capsules. So these were out in the wild. Jeez, probably going back. I want to say like before COVID, like probably like I remember these came out like 2018, 2019. Um, and I remembered taking them. And I was like, okay, it worked for like two or three weeks. Then by like the fourth week, I just noticed nothing from it.

13:25 And then after that, I just really noticed nothing from it ever again from taking the capsules. So five amino, if you don't know, is a small molecule inhibitor of this thing called NNMT, which is an enzyme overexpressed in fat tissue of obese individuals and inhibiting this enzyme shifts cellular energy balance toward fat oxidation. It basically also raises endogenous and intracellular NAD plus levels. And the problem with the oral is that it's a quaternary ammonium compound, which is permanently charged, making it very difficult to cross biological membranes,

13:59 including the intestinal lining. So oral bioavailability is likely around the single digit percentages, and most of the dose is excreted without reaching systemic circulation. Clients on oral capsules at standard dosing really report anything meaningful and the gap in outcomes between injectable and oral, is too consistent to ignore. And so again, here's the problem. One, the oral is really expensive. And, so most people take like 100 to 150 milligrams a day orally. You probably need like a thousand milligrams per day to which you would probably be spending like 40 or 50 bucks a, day on this to maybe get some result.

14:36 I do know from talking to manufacturers, it also is kind of a pain in the butt to manufacture because it stains everything in a capsule machine. So that's an interesting take two. However, the alternative would be to use the injectable form, and I am a huge fan of the injected form. Knowing now that we know that the oral absorption is probably in the single digit percentages, that makes sense because when you look at the dosing of injectible, I feel really good at like one to two milligrams. on an injectable, which could be anywhere from like two to three percent of the oral dosing.

15:12 If you were doing those one to two percent, the world does saying if you are only getting a single digit percentage absorption of And so same compound, dramatically better bioavailability. And I think for broader metabolic and fat loss goals, newer receptor agonists like RETA combined with the Injectable 5 amino are so much more powerful for fat-loss. I know people that take the dose of the injectable version up to like 10 or even like 50 milligrams a day. I have never felt the need to do that.

15:42 I take one to two milligrams per day and I feel like a massive energy burst from this and the fat loss is really good too. It is one that I would say to cycle on and cycle off of, but again, I think it works really, really well. A highly recommend the injectable version. And so again, the oral pretty worthless in my opinion, but the injectable vastly superior. And if you're going to use five amino, I will say it is orange. So if get the Injectable and it comes in an orange powder, do not be alarmed. You didn't have some like weird, weird color monster jump into your vial.

16:14 It is Orange and that is what you would expect to see. That's a good thing. If it's orange, if your getting injectible version, But I do like the injection. Its just the Oral. I've never seen that much out of it. And so when we look at the final thoughts, we've got AOD. I would swap that with TESA and or a GLP. We've go GHRP2, GHRP6. Let's swap with IPPA and CJC. HGHFRAG, same thing, TESSA or GLPs. Cimarron, I will swap it with CJ and IPA. And then 5-amino, oral. we're going to go to the 5 amino injectable. Again, as always, this is educational and entertainment purposes only content.

16:48 please take all this with a grain of salt. And again, I'm not here to ruffle your feathers. This is just my opinion because people ask me all the time which ones I think are worthless. So that is it for the slides. That is my list of the top five most overrated peptides. Interestingly enough, this was a harder video than you would think to make because I really did try to do my best to select the ones that I thought were pretty much worthless, I will grant that there are a lot of things out there that would be worthless to me that wouldn't be like very useful to someone else.

17:21 And I did my best to put these as like, in most cases, there's probably only like five to 10% of people that are buying them that these are actually useful for and then the rest are probably not really getting anything out of it. So when you're out there in the wild doing what you do, sourcing peptides, just be aware. And I don't say this. I'm not trying to like keep any companies from selling these peptide because I know plenty of companies probably have these on their books and they'll continue to sell them. Not trying tell you not to buy them and I would actually say, I wouldn't encourage you to by all of these and give them a test just to see for yourself.

17:51 So put it to the test, actually maybe say hey, Hunter, you are full of you know what why don't I go buy this and test it myself and then just see what it does for you and hey maybe you do get a good result but I've tried all of them that would be my recommendation to switch to something else if you're in the market for some of the things that these do. So that's it for this one. Just in closing, thank you guys so much for the overwhelming support that I received from everyone. Truly is a blessing to be able to bring these messages to you each and every week.

18:21 And I can't tell you how grateful I am to get to do so. So whatever shape, form, or fashion it is that you support me, whether it's using my code at places, You know, being on the email list, Being in my private group, sharing this with friends with family, whatever it is that goes so far in supporting me. Just know that I appreciate that more than you'll ever know. So thank you guys so much for that. And I will see you in the next one. Peace.