Retatrutide Masterclass | Dosing, Side Effects, and the Framework Most People Get Wrong

0:00 Hey everybody, this is Hunter Williams. I hope you're doing amazing wherever you might be in the world. Today's video is going to be all about read a true side. So what I'm doing right now, I actually secretly behind the scenes working on a book and what i'm And what I thought it would be cool alongside the book is for me to actually do kind of like a master class on each individual peptide and just cover everything that I know about it. So if you want a definitive guide on BPC or TB 500, or in today's case, Reta TruTide, one exists.

0:35 And I'm sure as time goes along, I will need to update these. and it's probably been about a year or year and a half since I've done more or less a long form video on RETA Truetide. And so what I want to do today is condense down everything that I knew about Reddit True Tide, everything, that, I could potentially research about red true tide and put that into a format that you understand and can walk away with pretty much my understanding of how to use it, whether it's on yourself or your coaching clients or you're patients or whoever it is.

1:07 And, so that's going to be my attempt on this one. We'll see. I think I've got around 60 ish slides for this. So it will probably end up being about an hour long. But we'll see. So that's my intention with this. And I think it'll be kind of cool. I love the idea of kind building like a peptide encyclopedia and doing that in a video format so that we have one of these deep dives on pretty much every available peptides out there that most of us can use and have access. So that's what we're going to cover today. I would love to hear your feedback on it in the comments, whether you liked it.

1:37 Uh, I know a lot of stuff in today's world is more short form. And while that is happening, i'm trying to go more long form and make things as boring and detailed as possible. So I'd love hear feedback. As always, make sure you're on the email list. That's the best place to stay in touch with me, especially with censorship on The Rise. multiple people are getting their Instagrams, YouTube, Spotify, TikTok, you name it, deleted. And so if you want to stay in touch with these, to make sure that if I do get taken down off of any of these platforms in the future, that you have a way to find the new platforms, email is the best way do so.

2:09 Obviously too, if would like to message me or come on coaching calls with me, the place to do that is inside of the Axion Collective. I get so many questions per day. There's no way I could respond to all of them, but I make for everyone in that group, I'm responding to private messages or thread and forum posts inside the group. And then also you can come on coaching calls with me. So check that out. Without further ado, I'm going to share my screen. All right, today is going to be the Reddit True Tide Masterclass. It's going be a practical guide. We're going look at what it does, how to use it, what most people argue about online, my thoughts around those things, and then what actually matters.

2:44 And so by the end of today's presentation is my goal that you could walk away, especially if you know anything about peptides with a full understanding of at least everything I know about Reddit true tide. So what is this for? We are going cover what does in your body. The two people that use one for weight loss and the other group of people being for longevity purposes. We're going to real world dosing strategies and the debates around dosings. We are going look at some of the mistakes people make too. And then we're also going looking at the metrics that matter. As of time of me filming this, it is May 2026. Red True Tide is not FDA approved.

3:15 Looks like it will be later this year or even into next year. we don't really know the exact date. I do know, I think things got pushed back because there were some heart rate issues, which we'll talk a little bit about today. But basically that's what we are gonna dive into. A little on the regulatory timeline as of this video, May 20, 26, still investigational. Again, like I said, late 2026 to 2027, an NDA filing is expected and an approval is likely in 27 to 28. We will see, I know with Orphor Gleepron, they got that approved pretty fast.

3:45 And so I think Reddit TrueTide has some things around it, but the legal situation is unsettled to say the least. Now, let's look at the two reasons why someone might use Reddit True Tide. One, we have the weight loss user. So this is typically going to be with someone with a BMI over 27, although I'm not a big fan of BMX. It doesn't really look muscle, but this the person that wants to lose meaningful body fat. Their goal is to have a 15 to 30% reduction in body weight. These people are going be the ones that need higher doses with full titration up to those higher dosage, and they're going on it for longer periods.

4:20 We're gonna talk about this today, I am not a fan of cycling off if you have not reached your goal weight. And I'll go more into that. But then on the other side, we have the longevity user. So typically, you're going to see this person has a BMI that's in normal range. They want to optimize every metabolic marker. Their goal is insulin sensitivity to reduce liver fat, to improve their lipid panel, which they will do if they're using it properly, improve blood pressure, decrease inflammation, and improve all their aging metrics.

4:50 This is where we're going to see the lower doses often micro dose. So we'll talk about that. And then this is, we are going see probably shorter focus protocols or low dose maintenance over time. But again, it just comes down to the goal user. Retatrutide does not distinguish between whether you're super healthy and you want to be healthier or whether your a weight loss user and so it's going take our discretion to really understand where to go with these. Different people have different goals at different doses at, different timelines. So again, make sure that you know what you are in this game for now.

5:22 Again, just to sum up what red true tide actually does. It's a 39 amino acids, synthetic peptide that activates three receptors. And you probably have heard this. Beat to death by now. But anyway, it's got a half-life of about six days. That will be important later. And once weekly, dosing is what is studied pharmaceutically. So we don't really have anything around split dosage from a clinical study perspective, but I'll talk about that. We obviously have GLP-1, it agonizes the GLp-2 receptor which cuts food intake, reduces appetite and slows gastric emptying.

5:55 Then we have the GIP which supports insulin sensitivity, satiety and adipocyte function. And then we the glucagon which increases our caloric output. It also raises energy expenditure and burns liver fat. and so two of the three reduce the calories in and then one increases the Calories out and So that's why reddish fruitide is so distinct because you have this simultaneous lowering of calorie intake pretty much like In most people where it's just doing it at will and Then you the glucagon agonism,

6:25 which is raising the calorie Expenditure that we're having and sort of like inducing this pretty big energy deficit within the body so The last piece is obviously what nothing else in the market does, at least alongside those two other factors. So when we look at the glucagon receptor, this is why red sugar is so different. Glucagon usually gets associated with raising blood sugar, which it typically does. However, that's not the relevant action here. The blood-sugar raising side is offset by the GLP-1 and the GIP, keeping insulin secretion robust.

6:57 So the fat burning side is unopposed. And why does liver glucagon signaling, what does it actually do? It increases liver fat oxidation, so you literally burn fat in the liver, and this is where it's so powerful. It also suppresses de novo lipogenesis, which creates new fat from carbs. This is why I think it is important too to realize that people that are very low carb sometimes might not do well on RETA, and actually the body gets much much better at handling carbohydrates and using those much more efficiently.

7:27 It also increases our resting energy expenditure and then it shifts the substrate handling away from triglyceride storage, which again is a long way of saying that it's going to help one, improve lipid profile, but then also to get fat off of the Now let's look at the weight loss case, what the trials are actually showing. So we have one milligram at 48 weeks, people have lost 8.7% of their body weight. And so I want people to understand like, okay, the, common debate online is like okay.

8:04 microdosing retrutide is bad. Let me ask you this. So if I am 215 pounds, I actually just weighed myself last night, 214 pounds right now. And I wanted to lose 8% of my body weight, which just for round numbers, let's call that 20 pounds. I know that's like about 10%, but let just call it 20 lbs. In clinical trials, and these are people that are not dieting, they are exercising in most cases that we know of.

8:35 one milligram of retichotide per week caused 8.7% of body weight loss. So I could basically, you're telling me I can lose like 15 to 20 pounds over the course of one year if I just take one milligrams of red retchotidide a week without changing the dose. And I think this is where in the research world, it's always like, especially with social media and stuff. It's always like bigger is better, right? And it's not necessarily always the case. I am not saying that some people don't need to go up to higher doses, but what I'm saying is that if I just inject one milligram of Registro Tide once

9:08 per week, which is like the most basic thing you could do, I'm still going to lose about 8.7% of my body weight, which for me would be almost 20 pounds. This is like 15 pounds to be conservative. And so what's crazy is that a lot of times we forget how powerful this is and we want to say, Oh, it doesn't suppress my appetite. Oh it. Doesn't work. If you just give it time, that's what it's doing here. And to be like the Warren Buffett, like compound interest guy, look at what he's is doing from a compound back.

9:39 Now let's go up to four milligrams after 48 weeks, which is basically a year, 17.1% of body weight loss. 8mg, 22.8%, 12mgs, 24.2%, and then 12 mg at 68 weeks has 28.7%. So that came out in December of 2025. There was 28,7% mean weight loss at 60 weeks at 12 mgs and the largest mean of weight lost reported in any phase 3 obesity trial. So again, the curve has not plateaued at 48 weeks with semaglutide and trisapatite plateau is the rule by 60 to 72 weeks and retitrutide keeps going.

10:16 So that is very interesting from a clinical data perspective just to have there. But I put this slide up here to just show you the perspective because so many people are losing retritrutite. I know people need to lose a lot of weight using it, but so may people don't. And if they're not losing four pounds a week, they just kind of give up. And it's like, Hey, look in people that were not doing all these things that most of the people in our community do. And they're still losing weight. So I just wanted to put that up there. Now let's look at the longevity side of this, because we want to look what else improves beyond body weight?

10:47 So this gets less attention, but at 12 milligrams, there was a mean reduction of 82% of liver fat. mean reduction of 40% in triglycerides, 24% reduction in ApoB, 22% production in LDL cholesterol, a 10-point systolic blood pressure drop, and 72% of pre-diabetics reverted to normal glucose. Fasting insulin was down by half or more at higher doses and HSCRP and other inflammatory markers improved.

11:19 A1C was also down 0.4 percentage points in non-diabetic. So when we look at the longevity case of reticulotide, these are all things, if I was looking at longevity, that I want to know about someone to indicate to me, like, hey, how healthy is this person? When I look in my blood work, These are things I like. Hey, How healthy am I? Do I have liver fat? I actually, you have to have a, I believe an MRI done. to measure the liver fat and I've had that done before and thankfully I have like basically zero liverfat which to me you could get into some of these small particles and stuff which I do think are important when we look at liver Fat that is one of the leading indicators of longevity.

11:55 Now, why do longevity users care? Well, we have insulin resistance, basically fatty liver, chronic inflammation, those are all central nodes in the aging network. So Reddit TrueTide is going to work on all of these directly, which is why I think it's so powerful. And so we chronically elevated insulin, Reddit true tides gonna reduce AMPK or excuse me. When we have chronically elevated insulin, that reduces our AMPK. It impairs autophagy, it increases mTOR activity, and it raises oxidative stress. Obviously, retitrutide addresses that.

12:26 When you look at liver fat, liver Fat drives systemic insulin resistance associated with accelerated biological aging on methylation clocks. Retitutide, like I just said, drops liverfat. We have visceral adiposity. So retritrutine is going to help with viscera adipposity Vascular adiposity drives inflammatory cytokines, which is the fat you cannot see that kills you. And then elevated APO-B, the strongest causal lipid marker for atherosclerosis. Retatrutide drops it on average by 24%. So for someone optimizing healthspan, this is more interesting than the scale number.

13:02 Now the lean biohacker question is where it makes sense for non-obese users. So if you are someone that is not obese, but you have high APOB or non HDL despite optimized diet, you've persistently elevated liver fat on imaging despite lean appearance. You have a visceral adiposity on a DEXA scan out of proportion to your total body fat. This is people that maybe your whole body isn't high, You have insulin resistance markers like high fasting insulin or a high HOMA in insulin resistant

13:33 index over 1.5 and a family history of type 2 diabetes, cardiovascular disease or hepatic disease. Those would all be situations where you want to do it. Now let's get into titration. because this is what has been used in a trial. And I think for someone that needs to lose weight, this kind of where we're getting into the playbook of how you would do it. So weeks one to four, you're going to start with two milligrams. I personally would never start someone who's not been exposed to retotrutide, and even someone has exposed retorzapetide on a dose higher than two millimeters.

14:03 And the reason I say that about trisapatite is so many people might be on like 15 milligrams of trizapatide per week and they want to go over to 15 mg of reddit and it is not the same thing. It's not same the thing whatsoever. I like to walk people down. So like maybe go from 15mg of Trisapatide to 10, to 5, and then to 2. And then, okay, let's now move over 2mgs of Reddit, then titrate up as needed. You'll probably have a four to eight week period that you do that, but I liked doing that a lot better than just jumping right over at the And so when someone's starting, we're going to start with two milligrams, weeks five to eight.

14:33 If they need to, they can increase to four milligrams. Weeks nine to 12, if they needed to they could increase the six milligrams and then weeks 13 to 17, If the need two, you can go up to 8, 9 milligrams And then 12 milligrams what I like to hold, it seems to be that eight milligrams is the sweet spot where you look at like maybe there's like a marginal weight loss difference, but all of those longevity markers actually stay relatively the same. And so I don't think for going 50% higher on the dose that you're really getting that much more benefit.

15:03 That's why I say eight milligrams seems to be the maximum effective dose I've read a true title in my experience. So a four milligram maintenance dose was studied as a long-term at lower burden option and people still do well on that. Just because you may not feel the appetite suppression does not mean it's not working in the background. Now, one of the biggest debates, and this is where we get into some of biggest of debates and at the end of today, I think the answer to any question about red trutide is just to take it, right?

15:33 Like if you just take, it you're going to do well. But let's look at this because we have once weekly versus split dosing. So the once-weekly, which is the clinical protocol. This is study and trials. We know the efficacy, we know safety for a pile. you have what is like a sawtooth pattern. So you'll have a high peak day one to two, and then you'd have lower trough day six to seven. That's just gonna be with it, right? And the peak to troughs ratio is around four to one, meaning that the highest highs to the lowest lows, there's a four-to-one difference in what you feel, so hey, I mean, that's like, if you wanna experience that, because you only wanna inject once a week, more power to you,

16:07 but some users get the end of week hunger spike when they're doing this. Conversely, we have split dosing. So you can do twice weekly, you could do Monday, Thursday, Monday Wednesday, Friday, Tuesday, Saturday, however you want to do it. What this does is it reduces peak concentration by 28%. So we get smoother appetite suppression through the week. We get lower nausea on the injection day reported anecdotally by a lot of people or the day after. Although there is no clinical trial validation, we have pharmacokinetic modeling. I will say I have talked to a lot of people that do both and people seem to get a smoother ride on the split dosing.

16:42 Now, does that mean that either is right or wrong? No, it just means whatever you have a personal preference towards is what you should do. And if you like feeling the same throughout the week, Do split dosing. If you like feeling a roller coaster, do once a week dosage. You know what's funny is actually, I think for some people, let's say you take your shot on a Monday or Tuesday and you're just doing it once per week. If you want to eat more on the weekend, I think you should do that. Meaning that if you wanna have a refeed day or you wanted to have cheat meal or go to a family reunion or a party or whatever,

17:17 take it on Monday or Tuesday. Take your big dose and then most people are gonna have kind of that trough come along by Saturday or Sunday and you don't feel as suppressed. And if that's what works for you, by all means do it. However, if you don't want to have an overwhelming appetite and you want eat a lot and drink a lots on those party days if want it more suppressed, break it up because you are going to feel more of the effects if your breaking up the total dose over three times per week. So those are my thoughts on that. When once weekly wins, you tolerate the once-weekly schedule. I understand a lotta people like this, I talk to them all the time.

17:49 They say, hey I just can't do more than one shot a week, like it's too inconvenient to me. by all means do it. If you want to match the studies, do. It if you value convenience, and if your early in titration and the doses are small enough, you can definitely do that. I've done this before when I'm starting out. Um, I actually did this with Masdutide. When I started on Masduetide, just started at one milligrams and I wanted to see how my body responded. And so I just did one milligram and waited a week until my next injection. Okay. So I think that's something that you could do if it's early on.

18:23 When does split dosing win? Well, if you have GI symptoms, you were going to do much better on split-dosing. If you get end-of-week hunger spikes and you want to avoid those, split dose is the answer. if your doing higher doses, I think it's much more effective to split them up even if it is just in two doses just because you don't have the same side effect profile of the higher dose. And then obviously if have frequent travel and needs flexibility around your schedule, i think its good to there too. Again, it's very easy.

18:53 Even if you're just breaking up into two shots, I think there are so many benefits for those reasons I just listed. Now three times weekly, is it worth it? You get a 38% peak reduction, so this is the smoothest blood levels possible. You obviously have to do more injections though. When we look at once weekly, we have a four to one peak to trough ratio. Twice weekly have 28% peak reduction, and then three times weekly we had a 38% reduction. You definitely could do daily microdosing, which is even more aggressive.

19:25 I don't really talk to that many people that does do that. And so I think beyond three time a week, it just becomes a little bit more OCD. But hey, if it works for you and you just do a shot one time per week. Three times though would be the, for me is usually the max that I do it. Now, this is a less common question, but still important. And so the next one would be morning versus night.

19:58 Basically, what actually matters is the four to 24 hour window after injection is when nausea and fatigue peak. So pick whichever timing puts that window where it bothers you the least. Some people like to do the night before a day that they're going to have lower calorie because they feel it more. I always do mine in the morning because I do fine. And so the question is, when do you want your side effect window at work, asleep or in training? That's the decision. So just time that up for yourself. But really there's no wrong answer when it comes to morning versus night.

20:28 The morning is better for lighter side-effect profiles, people with light morning appetite, morning training and early risers. Just inject 30 to 60 minutes before or after a small breakfast. Night case, if you have a heavier side effect profile, you might wanna do it at night. Demanding work or family schedules or headache prone users because some users get headaches after morning injections. So again, just do what works best for you. Now, let's talk about how far to push the dose. This could be one of the biggest things because the Dose Response Curve flattens between eight and 12 milligrams.

21:03 We look at eight milligrams at 48 weeks, the weight loss was 22.8%. If we look at 12 milligrams, which is 50% more of a dose, it was 24.2. Now that is a less than a 2% difference for a 50 percent increase in the dose. And so obviously we see, you would say that in math terms, that's called diminishing returns. So that a 1.4 percentage points of additional weight loss for 50 more drug. which means we get 50 to 100% more side effect burden. So for most users, eight milligrams is the right ceiling, 12 milligrams as the rate ceiling for severe obesity or non-response at lower doses and pushing

21:40 pasture tolerance ceiling is wrong move, hold longer at the dose that works. And I think that's the key point is because some people will say it's not working, then they look back after two months and it was working. It was just that it didn't get them shredded in 30 seconds or 30 minutes or a 30 hours. And so this is a very key distinction. Go back to that earlier slide where I was saying one milligram once a week caused 8.7% weight loss. Obviously, 22.8% is greater.

22:10 But do we want to do 50% more of the drug for a very, very marginal benefit? To me, that just doesn't make sense. One, it doesn' make economic sense and then two, It just as a make from a side effect profile sense, we're going to get higher heart rate, more nausea, and more bad things that we don't want from the drugs. And so I think that's something that's very, very important to think about. Just remember that when you're doing this. And again, I'm not saying that you don't need 20 milligrams a week of RETTA, but understand that it seems to be a parabolic curve.

22:40 Now, this is a bigger one. How long do we stay on? Every GLP-1 class drug study shows substantial weight gain after stopping or regain after stoping. So in a pooled meta-analysis, about 76% of weight loss is regained with a half-life of about 23 weeks. And so stopping is not graduation. Stopping is reverting. Frame it correctly from day one about what you're doing. What do we have? We have chronic use, which is indefinite, like any other drug that you are taking. I think for some people, they have to do this, right?

23:14 Look, do you want to be on a drug for the rest of your life? No, but do want be alive is the question. And I think if you look at someone, what is a greater threat to them? It is greater a threat for them to have visceral fat and body fat on than it is to taking Retatrutide in my opinion. So if someone is going to go off the drug and just regain all the weight, I would say they need to figure out a way to where they can incorporate that drug into their life on at least a regular, like a semi-frequent basis to able to manage their weight. Then we have cycled use, which is six to 12 month cycles followed by a maintenance dose tapers.

23:46 I kind of like this philosophy, with just blast and cruise, meaning if I want to lose some weight, I can go up on the dose till I get my weight loss and then I go back down to a very low dose just to get all those longevity benefits. And then you can use a pulsed cycle, would be 12 to 24 week protocols for specific metabolic goals. So maybe you're already the exact weight you want I think you should still use it for 12 to 24 week cycles just to get the liver fat benefits, the cholesterol improvement benefits. All those other longevity benefits I'm still a fan.

24:18 And so I can't sit here and tell you is it good to stay on or not. But what I can say is be intelligent about how you use it. And if that means that you need to stay on for the rest of your life, I think that's important. Now, does that mean in year three that are going to get the same appetite suppression as day three? Absolutely not. But it does mean is that it's helping you keep the weight off. If keeping the wait off is the goal, then we should really consider keeping that in the program for someone that's going to refuse to do all the other

24:51 things for weight loss. And so I kind of think about it like this, like some people, and I know them personally, I have family members like, this they are not going exercise. They are going not to change their diet. they're not gonna use testosterone. So for me, it's like okay, well, at least this is like a form of insurance or a safety net to help keep the weight off of me which is going cause me to die faster. And so if I'm rolling the dice on chronic use, I am willing to roll the Dice on Reddit True Tide versus being fat, is what I was saying.

25:23 And then from there, obviously it's more intelligent to use it in a cyclical manner or use in in pulsatile manner. But again, that's not going to be the case for everyone. And so what I want to talk about here is the longevity maintenance protocol. So phase one, we'd have titration. Working up to around a four milligram working dose. And then phase two, this is kind of this blast and cruise. We'd six month active phase to lower metabolic markers. Then phase three, would taper to two milligram or one milligram once weekly, or excuse me, twice weekly.

25:54 Could do once a week if you wanted to. Phase four would be to hold maintenance indefinitely and then to monitor labs. At two milligrams a week, weight loss effects are modest, but the metabolic improvements, and this is going to be for the healthier people, are well preserved. So again, just think about that. It's kind of that blast and cruise curve. We start two milligram, we take up to four or five, whatever your active dose is. Maybe it's there for six months. Then we come down and then we can maybe cycle off or go down to a very low dose. And then, Now, here's the lean user protocol.

26:27 I like starting at one milligrams a week, not two milligrams, which is the standard clinical trial dose. So I would start there. This is a lower starting point for lean users. And a lot of people, if they're lean, they don't really need to go higher than this. Like I said, one milligram a Then we hold that for four weeks, assess response, do not rush. And then you can increase the two milligrams for week if needed. Many lean users never go above two to four milligrams per week. Then you could also do this twice weekly. This works because insulin sensitivity, liver fat, and lipid effects are preserved at lower doses.

27:01 You do need to suppress appetite aggressively to get the metabolic benefits you are after. Most lean user find their working dose at two or four mg and the obesity population titration schedule is not going to be what is for them. Now, something I want to talk about, I know this goes without saying and it gets old hearing it, but protein and training are not negotiable. This is the biggest mistake in the entire community. A 100 kilo person losing 25% of body weight on red trutide loses 25 kilos total. About five to seven kilos of that will be lean mass.

27:32 That is not normal for the magnitude of weight loss. It is also, or that is normal and is avoidable And so protein is not negotiable. Whatever it is, I like one pound or one gram of protein per pound of lean body weight. And then again, you can calculate this and then resistance training, in my opinion, is non-negotiable, even if it's just two to three sessions for a week, a commercial gym and hop on a couple of different machines that hit each body part. You can do full body, you can to upper body lower body whatever it is.

28:02 Ideally it would be progressive overload. And without this Red True Tide produces a smaller and weaker version of you and so I cannot stress enough. It's one of those things I think for people that lift weights is so obvious, but For a lot of people, it's not. And I just know family members that I have, they just refuse to do this. A lot times they'll start to have maybe back issues because the muscles in their back are getting weaker because they're not doing it. When you can't eat enough protein, liquid protein is good.

28:34 So you could do protein shakes, obviously high density foods like Greek yogurt, cottage cheese, lean meats. These are gonna be prioritized over carbs and fats. And then low volume options, protein bars, jerky, hard boiled eggs. Those can all be things to help you get your protein in because they are more dense. Then I like to think of protein first eating. Just eat protein at the meal. Let's talk about some side effects, what to do and what you expect. So around 27% of people are going to get nausea. I think it's probably even higher, but I would say that's clinical nauseam.

29:06 23% are gonna get diarrhea. 18% or actually going through vomit. Obviously we want to avoid those as much as possible. What are we gonna do? We slow our titration. The problem is when people titrate every two weeks instead of every four weeks, it gets dangerous. And so I think titration should be at a minimum every 4 weeks and a lot of times maybe 6 to 8 weeks before escalating the dose. So that helps a lots. Obviously smaller, more frequent meals can help with this. Hydration is very important.

29:36 I want to talk about this because when you use a GLP-1 agonist, it also suppresses your thirst and it's very important to drink a lot of water. And so as hard as it is to eat, It's almost as to hard to drinking and what can be dangerous is that we're depleting minerals at a higher rate. So people get a lots of these side effects because they're dehydrated when in fact they need more water than they were drinking before, but they are going to be drinking less water that they have been drinking. And so you have to drink way more water than you actually think you need. And then again, the easiest thing to mitigate the side effects is just take the total dose and split up into at least two or three times per week.

30:11 Now, The heart rate question is massive. I would be remiss if I didn't talk about this on a Reddit True Tide Masterclass. So resting heartrate goes up from five to 10 beats per minute at higher doses. Even at lower doses, I've seen this in people, but clinically speaking. SEMA and TERS only had two to four beats per minute so obviously it is much more. There are GLP-1 plus the glucagon receptor because there are receptors on the heart can increase heart rate. So what's the first thing we can do? Obviously track it to know what it The heart rate increase seems to peak around week 24, but again, understand that that's six months in,

30:45 and then it partially declines after that. So understand, that you are going to have an increased heartrate on RETTA, whether it goes from 45 to 55, or 85 to 95. It is almost a guarantee that, it's going happen. The question is, what do you do about it? For me, I love adding taurine. And so I think on Reda I take five to 10 grams of tauring per day, which sounds like a lot, but it's what works well. There's plethora of clinical data around tauren being beneficial.

31:16 Touring can be massive, and so I would say every person on Retina needs touring. A persistent resting heart rate over 100 warrants positive evaluation. The net cardiovascular effect appears favorable and surrogate outcomes, but we don't have long-term outcomes on the heartrate. But again, the best thing you can do is add some touring in and then again try to manage your dose I will say for people that start this and the heart rate is like through the roof, understand that it does subside, but it just takes time. So it kind of comes with the territory and just understand what you're getting into. I have not found there to be some magic way that's not going to raise heart rates because that is just what it is.

31:50 This is pretty interesting. There has been a phenomenon of people Using we're at a true side that basically are getting very weird skin sensitivity issues. I actually in my own experiments tried to take the dose as high as I could, which I got to like five milligrams per week. And I did get a little bit of this because I wanted to see like what side effects would come and how I would manage that. So around 7% in obesity phase two trials had this. Basically they get tingling, mild burning, altered sensation without anything actually looking there.

32:23 And for me, I know when I got this, it felt like I had got like rug burn on my leg, but there was nothing there. Like I was like, man, did I like get rugburn on leg? And I would look down and there would be nothing. And this is what it feels like for anyone that's never experienced it. Now we see in higher doses at 12 milligrams, 21% of people, so basically one in five people get this. For type two diabetics at twelve milligram, it was only around 2%. So it is interesting. It seems to, at the same dose, not have the effect on different populations of different people.

32:55 Now, we don't really know what is going on here. Could be a ton of things, could be hormonal, nerve endings. Who knows? But what I do know is that I heard from someone and I tried this, topical magnesium spray applied to this seemed to help me. It seemed it help it go away. Also being very hydrated seemed help as well. So I don't know if it's a dehydration thing, but it does happen. And again, we don' really know what's going on. I experienced a little bit of this myself. Definitely not as bad as some people that know, But topically magnesium does seem to helps.

33:27 That would be my one recommendation. Obviously taurine, like I mentioned, But again, if this is one of those things and you're getting it, maybe consider either staying at the dose you are at or even lowering the dosage. Now, one of the things that I have to talk about that most people are not going to talking about is testosterone. So for men and women on TRT, red trutide is the best compliment amongst other things in my opinion. But we have redtrutides that drives weight loss and metabolic recovery. We get significant fat loss, reduces over aromatization, often improves the testosterone profile.

34:01 TRTs preserves lean mass, it supports recovery, maintains training. The TRT dose may need to change depending on the amount of retitrutide, but what I always like to say is to optimize testosterone therapy first, or optimize your testosterone levels, get the fundamentals dialed in, testosterone, thyroid, cortisol, sleep, training protein, then add retritrutite. And adding retretrutate on top of an unoptimized hormonal foundation is a big misstep. You should never introduce retrutitrate if you do not know what your hormones are and the hormones fixed.

34:36 Now, what is reasonable for bodybuilding and recomp stacks? Testosterone only at TRT doses with red atrutide for clean and re-comp, I think that is great. Adding GH or GH peptides for additional fat mobilizing effect, and then BPC, TB 500, a host of other peptide we can do for joint health recovery is all great, What you should probably avoid, and this is where I see a lot of people doing this in the recomp and bodybuilding world, running RETA during high stem contest prep with very low body fat can be kind of dangerous.

35:06 Also combining with high dose stimulant fat burners because of the cardiac risk and the increased heart rate I think is dangerous and then skipping protein and training while running aggressive anabolic stacks. So again, we just don't know how well these things combine with some of these more exotic agents. And so just be careful. I think Reddit True Tide can replace a lot of what is happening during a bodybuilding or a fitness person's recomp. And you might not need to take all the stimulants that you're doing and just being careful because again, understand that the Reddit is changing the energy

35:37 dynamics in your body drastically. We don't really have any precedent for it being used as a contest prep agent. Like we do with Klan or any of these other things that date back to 30 years of use. So something to think about anti-hypertensives, 30 to 41% of trial participants stopped at least one. So blood pressure will drop fast. And I say this, so if you're a lean person and you have low to normal blood-pressure, be careful because Reddit TrueType can make your blood pressures even lower. It doesn't do it directly, but it can. If you are using insulin or sulfur or arias, you may need to reduce the dose.

36:11 Also too, if you're a bodybuilding person, and you use insulin, understand that red is going to make you much more insulin sensitive. So just be careful with that. I think you shouldn't be on statins anyway, but statin can often be thrown away. Weight changes shift T3. This is why it's very important if you're on thyroid or you are not optimizing thyroid to understand how that interplays with RETA. I think one of the biggest mistakes people make is they take Reta, they lose a bunch of weight, then they get this neuroendocrine shutdown, their thyroid starts to shut down and they're not on something to support the thyroid, which my recommendation would be desiccated thyroid.

36:43 And then oral contraceptives, again, efficacy may be reduced during titration and dose escalation. So just be aware of that, that is an indication or a mix that could be there. When we look at metrics, what we want to look out on the course of using Reddit TrueTime, we'll look body comp, obviously. I don't care what it is, if it's a DEXA, InBody, BodPod, whatever it, is just something that you have a good baseline to where you can measure fat and ideally visceral fat to see where it going. Obviously resting heart rate, blood pressure, We want to look at our metabolic panel on blood work.

37:16 So we have a Comprehensive Metabolic Panel, otherwise known as CMP. Got A1C, fasting insulin, HSCRP. Then we've got lipids. We do a full lipid panel. Uh, we want and women, total and free tea, estradiol and SHBG. And then you can get liver imaging or fiber scan done. I think liver image imaging is pretty cool. And then how to think about your progress.

37:46 Obviously weight. I think people, they kind of get sideways with the weight and they want like three to 4% of weight loss per week. And that's just not going to happen. If you have one pound of loss a week, one to two pounds, you are right where you need to be. Now, if you're 500 pounds, you might need a little bit more per week. But for the average person, that they're doing one to two pounds per a week, the right we need to be. Obviously, our body composition is much more important. So a lot of people get hung up because they like the scales not moving.

38:16 And to me, If the mirror is moving, but the scale is not, moving I think that's a good thing, obviously in the direction. Metabolic markers are also important, but then also too is very important and is your subjective feeling. So how is you energy? How is training performance? how's your sleep quality? Let's talk about cycling and coming off. And so what I think, let's say we've been on eight milligrams, I've read a true tide for 16 or 64 weeks, whatever you want to say. Let us first set a taper start date.

38:48 Then what would I do is drop a dose every four weeks and that could be two milligrams. It could four milligrams I'd think two millimeters would be the good dose to start to come down and then move to two milligram weekly, which would kind of be like the max maintenance dose or you could stop. And so part of that is, hey, I know I've been on this for a while. Maybe I just want to give myself a chance to stop. I did this recently. It took eight weeks. During the first four weeks, i was on like five milligrams and I went down one milligram per week over four week.

39:19 So I got down to like one milligrams. And then I stopped and i stopped for really five weeks and because i did that titration down phase i didn't really notice a difference in that one month that I start that i stop And I know there's still a period of where it's like coming out of your system because it does have a six day half-life. But again, it is much better to taper down and then go off than to just stop cold turkey. What are some common mistakes that people make? Pushing past tolerance to chase a higher dose. Do not chase higher doses.

39:50 Chase results, not higher-doses. Obviously skipping protein and training. Daily weighing and emotional reactivity. So if you're weighing yourself every single day, It's a bad thing to do. Don't do it. Stopping cold without a maintenance plan. This is why 76% of people regain the weight within 23 weeks is because they don't have a Maintenance Plan of diet, training, hormones, all those things. Treating reddit is a substitute for hormone optimization. It will never, never never at least in its current form replace testosterone. running the obesity protocol as a lean longevity user.

40:22 I don't think you need to do this. A lean person will get in trouble if they're doing high doses for a long period of time. It doesn't mean they can't do it for short period time, but for long time and then not tracking your blood work. That's very important. Now, let's look at some FAQ. How do I start? One, decide why you're gonna do this. After everything we've talked about, decided why, you would wanna do. Get baseline labs and a DEXA scan, sort out your hormones first. So if you get your labs done and your testosterone is not optimal amongst other things, You should be doing red point blank period.

40:52 Start at two milligrams weekly or even one milligram if you're a lean user. Hold for those first four weeks and then assess. Do not rush titration. Four weeks should be the minimum. In a lot of cases, six to eight weeks is even better before you titrate up. And then tit rate up if tolerated well and goals require it. Then recheck your labs at 12 weeks if possible. If not, 6 months is okay too. What if I plateau? So this is a huge thing, what if i plateau, right? I lost 12% of my body weight in four months and now I've stopped losing weight. What do I do now? First, ask yourself, is protein still on target?

41:25 Most people drift down because their appetite is drifting down. Is your training still progressive? Maybe you're not even training, but most people drift to maintenance in their training. Has your sleep degraded? This kills weight loss. And obviously this is a problem too. If you are chronically stimulating the nervous system, one of those reasons being read a true tide, sleep will degrade. See if you were doing things that can improve sleep. Then has your appetite returned to baseline? Time to reassess the dose or look at other appetite suppressants. So then consider hold the current dose another four to eight weeks.

41:58 Switch to twice weekly for smoother peaks. Increase one dose level if tolerated well. And then take a diet break, so two weeks at maintenance calories with full protein and then back to a deficit. Sometimes adding more calories can actually accelerate fat loss. A lot of people are scared to do that because they don't want to gain the weight back. But as people from the bodybuilding world know, sometimes a refeed is what you need to get going. Another question, what if my labs improve but the scale does? Does that mean that it's not working? No, it actually is working great.

42:28 It's actually working spectacular. So let's say your APOB dropped 30 points, your liver enzymes normalized, you're fasting insulin is down in single digits, but you've only lost four pounds. Is the drug working. Yes, It absolutely is. So for a longevity focused user, this is the better outcome. Weight loss is one effective rate of True Tide. It's not the only effect. And for many users, it is not most important. If your goal was metabolic optimization, you got it. So again, how does this compare to Terzapatide? I'm on Terzaapatite and doing fine. Should I switch? I don't think so.

42:58 This is a big thing is like people get FOMO and they're like, Oh man, I should be on Reda instead of Terzapotide. I Don't necessarily think you should always switch. Sometimes TerZapTide I've seen this over so many people. Sometime Ter ZapOtide is much better option than RedA True Tide so When does switching make sense? Maybe you hit a trisapatite plateau, or you're just not getting it done on trispatite. Red tritide may break through where trizapatide stalled. And then you also want a significant drop in your liver fat. We're going to see more of that with rather than trishapatites.

43:29 So you could potentially switch there because the hepatic effect is meaningful larger with red trutide. If liverfat is an issue or your main target, switching makes sense. But switching agents has friction. So you have to re-tigerate. You may have deal with GI symptoms, heart rate issues, things like that. And the 6% additional weight loss is not a transformational different for most users. I'm of the opinion you can get all the fat loss you need on terzapotide. Is RETTA better? Sure. But you get get the all fat lost you on Terzaptide I am actually trialing right now low doses of Masdutide just to see how it stacks up.

44:04 Seem to like it so far. But again, RETA is not the only solution to weight loss. In a lot of cases, church appetite does just fine. And in some cases it might do better for a lotta people, especially people that don't want the chronic nervous system stimulation. When do I stop? Very good question. If you have severe metabolic disease, I don't think you should stop. So it's kind of like any drug that you need to sustain your life. You have obesity or diabetes or something, you probably shouldn't stop now.

44:34 Let's say you hit your weight loss goal. I would say, don' t stop until you Keep on it until you get to your goal weight, then go down, taper down to a maintenance dose for 12 plus month while lifestyle locks in because I think these peptides, especially red atrutei can be a catalyst for improvement and weight loss. And then if you're doing it for longevity, run a six to 12 month focus protocol, than taper to maintenance or go off and then rerun if metabolic markers

45:04 drift back. And so what is not a plan, I'm going to run it for a few months and see how I feel. That is just kind of throwing caution to the wind. And the question to when do I stop? You can't really answer that. The only person that can answer is you. Now, what about combining with other peptides? Can you use BPC or TB 500? Absolutely. Can use use KPV? I think you can and should.

45:38 I think one of the biggest mistakes outside of not using testosterone is not some sort of growth hormone support peptide or growth hormones itself alongside Rettitrutide to help preserve the lean mass loss. We will see these studies continue to come out, but there was one study that came out for women that were on BHRT with Terzapatide. They saw 35% greater weight loss milligram for milligram. So they got one third better or 33% better results just from taking hormones alongside the peptide at the same dose.

46:11 And so I think you pair hormones and you appear a GH or GH peptides and they can throw in whatever the other peptids make you feel good. Those are very important concepts to understand and utilize. What if I run out or miss a dose? Say you miss dose or whatever, not the end of the world. So within three days of a missed dose, take it as soon as you remember. If it's more than three day late, just skip it. And then running out at high dose do not abruptly stop. Please, please, I know I've said that a bunch of times today. please titrate down.

46:42 What is the framework? Well, let's look at some 10 rules or the 10 commandments. Decide what your goal is. Is it weight loss or longevity? Different doses require different plans and different amounts of peptide. Number two, sort out hormones first, TRT, thyroid, sleep, training base, and protein. Step three, start low, one to two milligrams weekly, hold for four weeks and then reassess. step four, titrate slowly. Most users find their working dose at four to eight milligrams. Set five, switch to twice weekly if peaks are punishing you. set six, track the metrics that matter that we talked about.

47:15 Step seven, plan your taper before you start. And so understand, like, don't just say, hey, today I'm going to taper. Understand where you're at and understand like hey by this time I want to be tapering. Step eight, pair with adequate protein and resistance training, which is non-negotiable. step nine, maintenance dose for chronic benefit, not full discontinuation. Then step 10, adjust based on labs, Not on the opinions of people that you hear on internet, including myself. Now, the bottom line, retitrutide is the most powerful metabolic compound available.

47:47 If there was a super peptide that we have available today, it would be retritrutid, point blank period, hands down. This is true for weight loss. It is also true every downstream metric of metabolic health, but the framework still wins. Who is the user that gets extraordinary results? They sort their hormones first, they train, eat enough protein, and use Rettutrutide as a focused tool. They get sustainably leaner, or substantially lean and sustainly lean. and they become a metabolic healthier version of themselves. The user who gets disappointing results treat Reta-TrueTide as a magic bullet for an unoptimized life.

48:21 They get thin, they get disappointing labs, and have to start over. And RETA-TRUE-TIDE, in a lot of cases, will cause more harm than good when they're doing those things. So when you're playing with dynamite, please be an intelligent user of dynamit because that's what Rete-true-tide is. It can be the best thing for us, but in some cases it can the worst thing. be the user that gets extraordinary results. And that is it for the slides. That is my masterclass of Reddit TrueTide. So hopefully I covered enough to help you get started or to improve your journey with Reddit true time.

48:54 I think at the very least, hopefully, I cover enough ground that if you've never used it before or you just been kind of praying and hoping, this gives you an intelligent framework to understand how to use this properly. And if I can do one good in the world is to help people more intelligently understand how they're using peptides and how their using hormones in their own life to achieve the health of their dreams and the help that they want in there life. And so I would love to hear your feedback on this one. I think the most important thing I could say is that red trutide is the more powerful peptide we have available today.

49:27 Use it wisely because it's not all sunshine and rainbows. It definitely has some downsides. Be conscious of those downs sides. Understand the blind spots and understand how to navigate it. And it is something that we're all figuring out. I think, like I said, there's those two buckets of users and your results will go back to how intelligently you're using it. And if you are a lean person that's taking the dose too high, you might not get the best results.

49:57 If you an obese person, that is not training and your hormones are not optimized, your not going to get best result. So again, hopefully this was a very good, thorough, comprehensive look. at Reddit True Tide. I would love to hear and I'm sure there's like infinite questions about Reddit true tide. And with this, I tried to incorporate as many of the most common questions I can, but I am sure that will be some more. So I'd love hear your feedback because this is an ongoing project. to help build out the future of peptide use. And so I'd love to hear as much feedback as possible on this one to let me know if these are good and if you like doing these,

50:31 because I plan on doing many more and I would love do more deep dives like this on each individual peptides. So that's it for this. As always, thank you guys so much. I always want you to know in closing, I am so grateful for the amount of support I get from everyone out there. It is truly a dream come true for me to get to make this type of content. So whatever shape or form or fashion it is that you support me, whether it's using my code at places, being on the email list, liking, commenting, subscribing, sharing with your friends and family that goes so far and helping me get supported to bring these messages to you.

51:02 Thank you guys so much. I always want to know you are loved and appreciated and it means the world to me that should do that.