A Complete Guide To Using Tirzepatide PLUS My Advice for 2024
I've been using tirzepatide on and off for over a year now. I'm not diabetic and I'm not overweight, but I've used it to get extremely lean. I also coach a lot of clients through fat loss, so this is something I wanted to know inside and out. Here's my full guide on how to use it, what it does, and what I've learned from running it on myself.
Where Tirzepatide Came From
Tirzepatide is a relatively new diabetes medication, but most people use it as a fat loss tool. It was developed by Eli Lilly and went through global phase three trials in 2021.
What makes it different from semaglutide (Ozempic, Wegovy) is that tirzepatide hits two receptors instead of one. Semaglutide is just a GLP-1 agonist. Tirzepatide works on both GLP-1 and GIP receptors.
That dual action is why most healthcare professionals consider it superior to semaglutide. If you're going to spend the money, get tirzepatide.
How It Actually Works
Tirzepatide stimulates insulin release from the pancreas and mimics the action of natural GIP at the GIP receptor. It has a greater affinity for GIP receptors than GLP-1 receptors.
It increases insulin secretion, raises adiponectin levels (a hormone involved in glucose regulation), and helps regulate how we metabolize sugar, fats, and proteins. The dual agonist behavior leads to bigger reductions in high blood sugar compared to GLP-1 only drugs.
Bottom line, it improves insulin sensitivity. That's the real mechanism behind the fat loss.
The Benefits
In type 2 diabetics, it's effective at reducing blood sugar levels and producing significant weight loss. But it works for non-diabetic people too.
I've seen it firsthand with clients. It can take someone from being in the diabetic range to no longer being diabetic based on their blood sugar, fasting insulin, and A1C.
The once-weekly dosing also makes compliance easy. You inject subcutaneously one time a week. No daily pills, no daily shots.
Side Effects
I personally didn't experience much beyond what you'd expect from lower blood sugar. Nothing dangerous.
Some people report nausea, vomiting, diarrhea, and abdominal pain. In my experience, those are usually people who already have a dysregulated metabolism and an inflamed gut.
Injection site rashes can happen. They're harmless, just keep them clean. Pancreatitis is rare and tends to show up in people who are very deficient in electrolytes and minerals.
Dosage
Start at 2.5 mg per week. Do not go higher than that to begin.
If you're already lean, I'd argue starting at 1 mg per week and seeing how you feel after two weeks is smart. The dose can be increased to 5 mg per week after four weeks, with further increases in 2.5 mg steps.
Maximum recommended is 15 mg once per week. I've heard of people going up to 30 mg per week, which is wild. At 2.5 mg my appetite is already shut down. I don't know how you'd drink water at 30 mg.
Here's the thing most people miss. Your body builds antibodies to peptides over time, which is why you have to keep titrating up. But if you start low and cycle properly, you can keep the receptors fresh and stay at a low dose long term.
I've been using tirzepatide for over a year and I still get amazing results from just 2.5 mg per week because I cycle it.
How to Reconstitute It
If you buy from a research chemical company, you'll typically get a 10 mg vial.
For 2.5 mg per week, add 1 mL of bacteriostatic water to the vial and inject 25 units on an insulin syringe once per week. That's it.
The Supplements You Need to Take With It
This part matters. Tirzepatide can cause dehydration and nutrient depletion. If you're not supporting it properly, you'll feel terrible.
Electrolytes (sodium, potassium, magnesium). Non-negotiable. You deplete these faster on tirzepatide.
Magnesium. Helps gastric motility. Tirzepatide slows gastric emptying, which makes you feel full but also constipated. Magnesium keeps things moving. I use OptiURX magnesium.
Vitamin B12. Tirzepatide drains B vitamins fast. Low B12 means low energy and lethargy.
Alpha-lipoic acid, chromium, cinnamon, berberine. All help with blood sugar and insulin sensitivity. Synergistic with tirzepatide.
Omega-3s. Helps cholesterol and heart health.
Vitamin D. Most people are deficient. I take 15,000 IU per day in winter and my levels still aren't that high.
CoQ10. Antioxidant that helps with blood sugar control.
Probiotics. Tirzepatide cleans up the microbiome. Probiotics support that.
Metformin. I think most people should be on it. Helps with systemic inflammation, supports good gut bacteria like akkermansia, and works through different mechanisms than tirzepatide for blood sugar control.
HGH or an HGH peptide. This is the one nobody talks about. People say GLP-1s cause muscle loss. Not lifting weights and not eating enough protein cause muscle loss. Lift weights two to three times a week, do fasted cardio, and add HGH or a peptide like ipamorelin or tesamorelin. You'll keep muscle while burning fat. The number one thing your body can do to burn fat is have more muscle.
My Personal Experience
The two times I run tirzepatide each year, I drop my body fat by 4 to 6%. I usually fluctuate between 5 and 10% body fat depending on the time of year.
Staying at 5% year round isn't feasible or healthy. I'll get up to 10%, sit there, and cut back down a few times a year, usually before summer or a vacation.
It significantly reduced my food intake. I still made sure I was getting enough protein, but eating became harder.
Where it really shines for me is fasting. It made 36 to 48 hour fasts effortless. Tirzepatide eliminates the suffering of dieting. Whether you need to lose 100 pounds or get from 10% to 5% body fat, that's the biggest win.
It also kills junk food cravings. I'd actually crave lean protein and clean carbs. That alone is worth it.
I had no muscle loss according to BodPod and InBody scans. But I'm on therapeutic testosterone, HGH, and I train hard.
Cycle On and Off
This is where people mess up.
Use tirzepatide for 8 to 12 weeks at a time when you're cutting, then come off for 8 to 12 weeks. Receptors stay fresh. You don't get dependent. You don't need to keep climbing the dose.
If you need to lose 100 to 200 pounds, staying on longer makes sense to get to a healthy weight. But once you're there, get off it.
Could you stay on a lower dose long term instead? Sure, going down to 1 mg for a stretch would be better than staying at 2.5 mg forever. But I still think cycling on and off is the right call.
I haven't seen rebound weight gain in myself, but I'm strict with diet, training, and fasted cardio. Most rebound weight gain comes from poor lifestyle habits, not from coming off tirzepatide.
My Take
Tirzepatide is the best fat loss tool I've used. It got me to the leanest I've ever been while holding the most muscle I've ever had. There's a lot of misinformation out there, but if you start low, cycle smart, lift weights, eat protein, and supplement properly, it works incredibly well. It's not magic. It's a tool that makes the hard part of dieting bearable so you can actually execute.
Full transcript click any paragraph to jump video
Hey everybody, this is Hunter Williams. I hope you are doing amazing wherever you're at in the world. Today's video is going to be about Terzapatide, and I am doing a comprehensive guide on Terzaapatides, how to use it, the mechanisms, benefits, side effects, dosages, as well as a little bonus, which is gonna be my personal experience now that I've... I've been using Terzapatide on and off for over a year now. And I say that as not someone that struggles with diabetes, I'm not somebody that struggle with obesity or being overweight, but I have used Terzaapatides to get super lean. Um, and also too, have a ton of clients that I coach on fat loss.
So it's something that wanted to be able to use on myself. I know how to recommend it to them. Today's going to my full, uh, no holds barred guide on Terzeratide. It might be a little bit more of a long winded video and that's okay because before my other channel got deleted, this is one of my more popular videos and I think it helped a lot of people. I learned how to use Terzapatite, especially if they're doing it themselves, meaning they are buying it as a research chemical from a Research Chemical Company instead of getting it prescribed from their doctor, which can be really expensive, sometimes upwards of $2,000 a month to get a prescription for Manjaro.
But if you don't want to do that, you can buy Terzaapatide as research chemicals. and get great results yourself for fat loss, whether you need to lose a hundred pounds or you're just trying to get, you know, from 10% body fat as a man down to like 5% of bodyfat, which I've used to do it before previously. So church appetite is amazing. We're going to a comprehensive guide on it. Before I jump into that, first of all, thank you so much for being here. If you are new here, welcome. My name is Hunter Williams. I am rebuilding my YouTube channel, and this is one of my first videos that I'm publishing on my new channel because my other one got deleted. So the best thing you can do to help me grow is to like, share, comment, subscribe, because it helps push this out to other people that are looking for
similar content on how to use peptides. And if you want to make sure you follow me in case I ever get deleted again, sign up for the peptide cheat sheet down below, which gives you Uh, all the instructions on one spreadsheet that you can post on your fridge at your house and use, uh, for every peptide, every popular peptides that need, including trisapatite. So it tells you how to reconstitute it, how do, um, dose it. How many units to pull on the insulin syringe and all that good stuff. Check out the peptide cheat sheet and it will sign you up for my email list so you get updates and you also get links to all my products and services that
include discount code. So that being said, let's jump into Terzapetide and talk about how to use it and why we can benefit from it. Where did Terazapitide come from? It's a relatively recent addition to diabetes It's really a diabetes medication, but I would just call it a weight loss medication and a fat loss. Uh, to be developed in the last few years is it was specifically designed to target both the GLP one and G I P receptors. So, uh, whereas we'll go via Rosen pick is a, or otherwise known as semiglutide is just a GL P one.
targeted medication. Trizapetide works on the GLP-1 and GIP receptors. So the development involved extensive clinical trials to evaluate its efficacy and safety and is an analog of gastric inhibitory polypeptide, which I mentioned was G.I.P. And it most recently underwent global phase three trials in 2021. I'm sure there's been some updates since then, but that's just what I did on my cursory research. So again, it focuses on dual receptor activity and it was developed by Eli Lilly. It was designed to improve the uptake into cells and stability to metabolism and its development is part of an effort to enhance insulin regulation and
diabetes management because that's what people with diabetes struggle with. So the drugs approval was based on the results of several successful clinical trials blah blah, blah. Blah. I know you guys want to know how it works and why it worked So just outside combines the effects of glp1 and gip hormone So it stimulates the release of insulin from the pancreas and the drug has a greater affinity to gp receptors than to gl p1 receptors and So trisapatite mimics the action of natural GIP at the GAP receptor at cell level, and at GLP1 receptor it shows a bias toward cyclic AMP generation, again which is where it's going to help us burn more
fat through the insulin signaling that it works on. So it increases insulin secretion through biased agonism, and it also increases levels of adiponectin, which is a hormone involved in glucose regulation. So again, when we talk about fat loss, we're really talking about like regulating and improving our insulin sensitivity, Which is why it does appetite work so well. It is chemically modified by lipidation for better cell uptake and the drug helps in regulating glycogen, sugar and lipids metabolism. Basically that's fats and proteins, so it helps regulate how we metabolize those and trans appetites dual agonist behavior leads to greater reductions
in hyperglycemia, which is otherwise known as high blood sugar, compared to GLP one only Agonists. So this is why, in my opinion and the opinion of most healthcare professionals, Trazapetide or Monjaro is going to be superior to semaglutide, which is just working on GOP-1 agonist. So a lot of people have gotten great results with semoglutaride as a GOp-I aganist, but I would argue that trazapatide is far and away better than that. If you're going spend the money on it, I'd just say get trazepotide. I know it could be a little bit more expensive. So what is the benefit? So for what we know, at least in type two diabetes patients, which are obviously people that are much unhealthier than someone that is lean,
it is effective in reducing blood sugar levels. So it leads to significant weight loss in diabetic patients but also people who are not diabetic as well. And it does this by improving glycemic control more effectively than a lot of the other existing treatments, and it offers a sustained effect on reducing sugar blood levels and weight. It can be used in combination with other diabetes medications which I'm gonna talk about a little bit later. Um, it also shows promise in, uh, not only improving, but eliminating both diabetes and obesity. And I've, I'm seeing this firsthand with some of the clients I worked with. Um it basically can like take them from being in the range of being a diabetic to not no longer being diabetic based on their blood sugar,
their fasting insulin, and their A1C. The once weekly dosing schedule improves patient compliance. So again, this is just something you have to inject subcutaneously once per week. It's very easy to do. You don't have take a pill every day. take your pen or your insulin needle and you know do a subq injection once a week and also by increasing our glucose utilization and insulin sensitivity it has the potential to reduce cardiovascular risk for disease and it may improve insulin sensitivity.
And again, this is more of like a new approach to diabetes. So what are some of the side effects? Uh, now I will say this something that, you know, everyone's different. I personally didn't experience like really any side-effects other than what would be a side effect of lower blood sugar from trisapatite. Um, which is not dangerous or anything, but, um, some people report nausea, vomiting, diarrhea, and a lot of times in my experience, those are people that are already metabolically dysregulated and have a very inflamed, uh, gut microbiome. Some patients may experience abdominal pain and indigestion, Injection site reactions are possible, so you could get a little rash on the injection site,
which is pretty much harmless. Just don't let it get infected. Some people had pancreatitis. That's very rare that that happens in my case. It is because they are very electrolyte deficient. Because they're not getting enough electrolytes and minerals into their cells, some of the organs tend to not work as well. And again, like we said, the allergic reactions. So what is the dosage? So the starting dosages is 2.5 milligrams per week. If you have not taken terzapotide, do not use more than 2 point 5 milligrams for a week to start out.
You will probably overwhelm yourself. And if you're someone that's lean, I would argue to, start with maybe even one milligram for week and see how you feel after the first two weeks. But this can be increased to five milligrams a day after four weeks and further increments can made in 2 .5 milligram steps based on glycemic control. Now, we get to the maximum recommended dose is 15 milligrams once a week. I have seen a lot of people with that 15 mg a dose, or some even higher. Even heard of the people at 30 mg per week, which I don't know how you would even drink water or eat like a cracker if you were taking 30mg at your appetite,
because at 2.5mgs per weeks it shuts down my appetite. So, I'm going to talk about this in a second, but we want to be able to maintain a low dose for the long term. Meaning, yes, if you're going to have to be on this and you need to lose 100 pounds, you are going have increase the dose like every four weeks, probably, because what happens with peptides is you get this thing called antibody buildup, and over time, basically, your body builds up antibodies to the peptide and will create an immune response, thus rendering the peptide less effective. This is why we have increased and titrate the dosage up to get the same results that we did when we first started.
But if we're starting at 2.5 milligrams per week and we cycle, which I'm going to talk about in a minute, we can keep the cell receptors fresh and still get really good results from 2 point 5 milligrams a week. I've been using Trisapatite for over a year, but because I cycled it and I have been smart about how I do it, I still got amazing results with just 2 .5mg. Now, someone that is overweight, I've talked to people that I have personally coached and they have to go up to like 15 milligrams once a week, which, you know, like, is that necessarily a bad thing for the body? I don't think so if you're trying to lose fat because the fat is going to kill you faster than, a bigger dose such as appetite will.
However, it can be very draining to the pocketbook. So 15 mg once per week. You're talking like Best case scenario like three to four hundred bucks per week of turzapotide. Whereas if you're just using 2.5 milligrams per Week, you know, You can get away with like 250 bucks a month Maybe even less depending on where you buy it from and then obviously it's administered via subcutaneous ejection So all you need is an insulin needle and I'm gonna talk about exactly how to reconstitute and all that stuff here in a second Um, so basically there it is. So a 10 milligram vial So typically if you buy from a research chemical company, you're going to get a ten milligram.
Vial of trisapatite So what you do if want to inject 2.5 milligrams per week, uh, You can check out my bacteria static water and peptide math video But one milliliter of backwater into the vile and then you are going inject 25 units on an insulin syringe one time per Week for a dose of 2 .5 milligram so very easy. That's all you need to do so Now, what I want to tell you right now is when you're taking terzapatite, it is very, very crucially important that you have a regimen of supplements that are taking alongside with it.
Because of the way terzaapatide works, there can be especially issues with dehydration. So there are some side effects that can cause dehydrations that just not going to feel good. Uh, so for anyone that I coach that, uh, have on terzeapatitde in order to, you know, get lean, improve, um, insulin sensitivity and help with fat loss. These are going to be the supplements. So the first one is magnesium. Everyone's efficient magnesium, I don't care what you say, unless you're getting magnesium from one of the best supplements, which I use Billy Weese's OptiURX magnesium you can check out Opturx.com or just look it up on Google.
They have the best magnesium supplement and I take that. You have to have, to use magnesium when you're taking trisapatite. One to improve gastric motility. So, um, trizapatide basically works to slow gastrik emptying, which is why it makes you feel fuller and it suppresses your appetite. Um, so magnesium is going to help keep things moving through your stomach and make you not constipated when your, uh, using trishapotide. Omega-3 fatty acids, obviously this is important for everyone to use, but it can help improve cholesterol levels and heart health, which is going to work in synergy with your zapatide.
Vitamin D, again, most people are deficient in vitamin D. I take 15,000 I use per day in the wintertime, and my levels are still not that high. They're like somewhere in 70s or 80s. on, you know, a normal basis. So the next one is alpha-lipoic acid. This is an antioxidant that may help reduce blood sugar and alleviate symptoms of diabetic neuropathy. Really good to take along with trisapatite to help with insulin sensitivity. B vitamins. Anytime we have some of these medications like trizapatide, it tends to deplete B vitamin at a faster rate, especially vitamin B12. What you need to make sure you're doing is supplementing with vitamin b12 because you can tend to drain that more fast or faster when you're using trisapatite
and then you have low energy and lethargy and vitamin B12 supplementation is going to help prevent that. Another one is chromium, so this is also a glucose disposal agent. It's useful for improving blood sugar and insulin sensitivity. Cinnamon, same exact thing, works really well. So ALA, which is alpha-lipoic acid, chromia and cinnamon, plus berberine all work to regulate blood sugar, so it's only going to be that much more synergistic when you're using trisapatite along with those supplements. Probiotics, obviously very important as you are cleaning up the microbiome, which trizapatide does, by increasing GLP and GIP,
or GLp-1 and GDP, and so probiotics are huge. And then we've got coenzyme Q10, an antioxidant that may help with blood-sugar control and prevent diabetic complications. Then I've three that are very imporant. So these are like the ones that I would say every single person needs to make sure they're doing if they are using So the first one is going to be electrolytes. So we've got potassium, magnesium, and sodium. They are vital for maintaining fluid balance, nerve function, muscle function in patients with diabetes. Or if you're trying to lose weight in your ovaries, even if don't have diabetes, they might experience electrolyte imbalances due to the disease itself
or as a side effect of certain medications. Supplementing of electrolytes could help maintain the necessary balance thereby supporting overall health and keeping us hydrated when we tend to deplete those minerals and nutrients faster when using trisapatite. Now, we've got metformin. So I say met formin, everyone should be taking it because of its effects on systemic inflammation, which we are all exposed to very dangerous toxins in the environment. Metformins helps with that. It helps up regulate acromonsia, Which is the good gut bacteria that we want in our body.
And then also too, using metormin with your appetite could provide a complimentary approach to managing blood sugar levels as they work through different mechanisms to improve diabetes control and help with weight loss. The last one, this is where you will not hear a lot of people talk about. So everyone says GLP-1s and GIP peptides cause muscle loss. No, not lifting weights and not eating enough protein cause muscles loss, so what is one of the biggest, most important things you can do when using trisapatite is to make sure you're lifting weight.
And if we're lifting weights, something that works really, really well to help increase the amount of fat we are burning and maintain muscle at the same time is using human growth hormone, otherwise known as HGH, or an HGH peptide. So HTH obviously plays a lot of roles in the body, especially as it relates to our metabolism. In the context of diabetes or obesity management, HCH or HHH, peptides like ipamarylin or testamorylin, a host of other ones that we could go into, which I'll say for other videos, could potentially aid in improving body composition by increasing muscle mass and reducing fat.
So this could be beneficial for diabetic patients, especially those with obesity. The number one thing we can do for our body to burn fat is to have more muscle. And if we are taking to our appetite, we're lifting weights two to three times per week, and we were doing fasted cardio, the HDH increase through HGH itself or an HGH peptide is going to massively improve our results with trisapatitis. It's going help maintain the muscle that we need as we're losing fat to help keep our body have a high metabolism and high base metabolic rate. So those work really well.
I'll give you just a little insight of my experience. Again, I've used trishapatite for over a year now, and I wasn't fat, to begin with, or anything like that, but I wanted to have my own experience and see how it suppressed appetite and how I'd help me burn fat. Um, the two times that I take it, I reduce my body fat, um, anywhere between four and 6% twice throughout the year. And again, typically fluctuate between five and 10% bodyfat, depending on the time of the. Um. Staying at 5% Body Fat year round is just not feasible and it's not really like necessarily healthy in the long run. So typically, you know, like I'll get up to 10%, body, fat.
I kind of sit there and I will cut back down to 5%, Body fat a few times a year, especially like if it is the summer or something, or I'm coming up on a vacation. So I definitely noticed that it significantly reduced food intake for me. Sorry, I forgot to put that on the slide, but it's significantly reduce food intakes, so decreased my appetite. With that, you still need to make sure you're getting enough protein. So even though it was harder to eat, made sure that I was getting the protein and where it really shines is allowed me to do extended 36 to 48 hour fast with ease. So basically it turns appetite, eliminates the suffering when it comes to dieting.
So that's, I think that the biggest benefit, whether you need to lose a hundred pounds again, or you're just trying to loose like the last few pounds of body fat that you have to get shredded. Um, it allows you to do those fast, which are going to be, uh, like, the advanced expert level thing when It comes To getting shredded, Uh, that You need To do. It allows You to Do those Fast with ease instead of being in a state of suffering, and feeling like you are starving. What's also really cool about trisapatite is that it changes the cravings for junk food. So rather than craving junk, food, I was like, man, really wish I had some lean protein and clean carbohydrates, which how many people can say that,
you know, obviously we're exposed to like tons of different food on a regular basis. Um, and trizapatide kind of like nukes the cravings of those. So what I'd also noticed in my experience, I did not have any reduction of muscle mass according to BodPod or in-body scans during the times that I used it. And that's because I'm using hormones, like I am using therapeutic testosterone, human growth hormone and weight training. What I say is that you must cycle on and off after eight to 12 weeks of use. So this is where people mess up. Again, if you're in a state where you need to lose 100 pounds, 200 pounds it is more beneficial for you to stay on trisapatite to get down to the weight
that you need to be. But once we do that, we don't want to become dependent on it. So I want use trizapatide for eight to 12 weeks at a time when I'm cutting down, and then I might go off of it, so I may use it for 8 to12 weeks on and 8-12 week off. And when do this, it keeps my receptors fresh and I don t have to use as much to good results. I am not going to this year round. Now you can make the argument, could you go down to like a lower dose for an extended period of time? Yes, that would be better. So it would better to go to a one milligram dose, for eight weeks, and then maybe take it back up to two and a half milligrams.
But I think in the long run, you want to on and off of it. And I don't think it causes rebound weight gain when you come off it like, a lot of other fat loss medications would. I haven't experienced that myself, but I also I'm very strict about dieting. I am very sure about my exercise and my strength training, my fasted cardio. So, um, you know, I wouldn't want to see anyone get to that point where they like rebound weight gain. And a lot of times the rebound, weight, gain is not going to come from coming off for Zaptide. It's going come, from you having poor lifestyle habits. Uh, that is a must use it for eight to 12 weeks on and eight, to twelve weeks off.
Yeah. Your healthcare provider is probably not gonna say that, but just in my own experience and in practice and coaching, all the people I have in our coaching groups and one-on-one clients that I Um, that is an absolute must. So that's kind of my experience with trans appetite. Um you know, it definitely gets you, got me like to the leanest I've been, um, with the most amount of muscle I'd been at ever, you now, ever in my life. You can definitely use it. There's just a lot of misinformation and disinformation. out there about people. So that is why I created this guide for you guys to be able to have and reference and use whenever you need to use Terzapatite.
Hopefully that was helpful. I think I covered everything, but if I didn't, leave a comment below or question down below for me so I can make sure I update and make a new video about Terzaapatide. But again, this is one of the more viewed videos on my old YouTube channel and I want to get another one out for you guys. So again, check out the peptide cheat sheet. It's everything you need to know about peptides. If you want use diurzapetide or any of the HEH peptidies we talked about today, I've got info on how to use those in the Peptide Cheat Sheet. And then obviously too, got all those other links down there. Also I forgot to mention, in I think in beginning, a video topic request form.
so if there's a certain topic around peptids, fat loss, hormones, anything like that you wanna covered, submit a request in that link and I will do my best. I've already got a ton of questions in there that I'm going to be making videos about coming up in the future. So again, thank you guys so much. Like, share, comment, subscribe, all that good stuff to help push this out there to other like-minded people like us. And I'll see you next time. Peace.
