CJC-1295 with DAC vs No DAC What Every Researcher Should Know

0:09 Hey everybody, this is Hunter Williams. I hope you're doing amazing wherever you are at in the world. Today's video is a long time coming and I actually realized I didn't have anything about this on my channel. And this was a much needed to do video. So a little bit back to basics here, but stick with me. today's videos is going to be about CJC 1295, no DAC, as well as CJ C1295 with DAC. so today I'm just going do a good old school breakdown of a peptide. We're going look at the mechanisms. the benefits, any side effects, and the dosage of really both of these two peptides are the kind of the same thing.

0:42 So I think I had a video on my old channel about this. I just forgot that I hadn't done a new channel on this, so again, back to basics here, but I this will be helpful just in helping explain to some people how these peptide work. And then kind a lot of times you'll see these group with other growth hormone peptids like epimerelin or testimeralin. Hopefully after today's video, you'll kind of have an elucidated understanding of why these, why CJC1295 is broken up into these two different types and

1:13 what the pros and cons of each of those are and then how you would use them and you use alongside to achieve results. So hopefully this will be helpful and informative to you, whether you're a veteran peptide user or you are a newbie and it's your first time and just researching peptides get started. That being said, if you are new here, welcome. If you're interested in more about peptides, I would highly recommend you go to the description of the video, check out the peptide cheat sheet. It'll sign you up with my email and you'll be on my e-mail list and I send informative emails every day about Peptides and learning how to biohack your

1:46 best life. And also too, if you want to check out the best and the most amazing community on the planet for information around peptides and hormone optimization, that's called Fully Optimized Health. It's a group that Jay Campbell and I have, and we are talking about this stuff each and every week. We have live AMA calls where you can ask us anything. And we obviously have a forum where can talk with us or with any people there. You can also message me directly. Without further ado, I'm gonna share my screen and today we're gonna do a deep dive comprehensive breakdown of CJC 1295 and whether it is with DAC or without DAC.

2:23 All right. I am Hunter Williams and this is the video breakdown of CJC 1295 NoDAC and CJ1295 with DAC. So we're going to look at the mechanisms, the benefits, side effects, and dosage. Let's get into it. What are these two peptides, which are really the same thing that have just been broken up into? two different types of molecules. So I'm going to explain this. Cjc1295 without DAC or no DAC is also called ModGRF1-29.

2:53 I am going call it CJC no-DAC for ease of use, but those are oftentimes interchanged. If you're ever on research websites, buying peptides, which you should never ever, ever do, Got to keep the channel clean. Right. But, um, so, uh, CJC one two nine five, no DAC. And again, you'll see that as my GRF one, two, nine, it's a synthetic analog of growth hormone releasing hormone GHRH. So it a modified version of the naturally occurring peptide GHH and stimulates the release of gross hormone from the pituitary gland naturally.

3:29 Basically, the way it works is it binds to the GHRH receptor and the pituitary gland and promotes the natural release of growth hormone. It also mimics the body's natural growth-hormone pulses, which are typically short and sharp. Don't want to short, it's short-and-sharp, but CJC1295 with DAC, basically this peptide, and it has this thing called a drug affinity complex attached to molecules. So it is also a synthetic analog. of GHRH, but it's been modified to have a much longer half-life.

4:02 So really, when we look at DAC versus no DAC, if it is with DAC that means it has a longer, half life. The DAC allows it to stay in the bloodstream much more longer than no-DAC and provides a more sustained release of growth hormone. Similar to CJC noDac, CJ with DAC binds to GHH receptors in pituitary stimulating growth, hormone release. But because of the DAC modification, the stimulation occurs over a prolonged period rather than the pulsatile burst, which is actually much more congruent

4:32 with what the body naturally does. So that's the difference there. Let's get into it a little bit more. Look at Nodac. Again, this is CJC, NODAC mechanism. Basically when it binds the GHR receptors, these are located in somatropic cells in the anterior pituitary gland. When it finds these receptors it activates a signal transduction pathway via GPCR. So this can lead to an increase in the intracellular levels of cyclic AMP.

5:02 Now what happens is this rise in CAMP activates protein kinase A, which phosphorylates transcription factors that regulate the GH1 gene leading to the synthesis and secretion of growth hormone. That's basically all you need to know. When we do this, it closely mimics natural GHRH in a body, which is a release in a pulsatile burst all at once like that. And the peptide is short acting, which means it induces a sharp, quick release of growth hormone. So this mechanism mimics the body's natural rhythm because that's how the produces and releases growth hormones.

5:38 Also an important regulator of Growth Hormone Release is somatostatin, a hormone that inhibits growth, hormone secretion. Um, so it works most effectively when somatostatin levels are low and keep that in mind, because we're going to talk about that a little bit later. So it is not override soma stat somatosatin inhibition, but takes advantage of periods when the body's naturally reduces, uh, somato statin output. Again, keep in that mind later, cause you're probably going have a question when that comes up later so stay tuned to the end. So, CJC NoDAC has a short life of around 30 minutes, which means that its growth hormone releasing effects are brief, but intense,

6:12 and again, sharp. This aligns well with the body's natural GH secretion cycles which are short and sharp, so now let's contrast that with DAC. So similar to NoDAC, DAC binds to the GHRH receptors on somatotropic cells. So it does the same process in the body. However, the DAC modification allows it to bind to albumin in bloodstream, giving it a half-life of update days. By binding to this albumins, it's going to promote a continuous release of growth hormone, leading to steady set elevation in a blood stream.

6:45 As such, we don't have to inject it as frequently, whereas with NODAC, you would need to eject it one to three times a day to really get all the benefits. We can do this two to times three a week. And in doing so, it leads to sustained elevation of IGF-1 levels, which obviously can contribute to muscle growth and fat loss. However, that's not always a good thing. I'll explain why, but there's also the risk of somatostatin feedback loops due to the prolonged presence of CJC with DAC and the bloodstream. So potentially we could have some negative consequences of this, and we're going to get into that a little bit later.

7:16 So what are the benefits of CHC without DAC? Really, they're what we know and love growth hormone for. It's fat loss. Again, the natural pulsatile nature of that is going help the body's kind of rhythms of how we have fatloss. If you're taking it before fasted cardio, it's going enhance the fat lost from that fast cardio. Also, if we take it before a lift or after lift, you can support muscle growth with GH pulses. Short boost, short burst of growth hormone, improve recovery times, obviously in healing. Obviously for anti-aging, it works well.

7:46 It slows the aging process. Definitely improves sleep and overall wellbeing because your sleep is enhanced. And obviously too, It supports joint repair from any injuries we have or soreness. Then it also helps bone density, which is huge, although not as much as testosterone, um, Which is important for everyone. But let's look at no DAC. So again, really the same thing, fat loss, muscle gain, recovery and healing, anti-aging sleep, and bone and health. However, the thought is with DAC that it would be better to have elevated levels of growth hormone and IGF in your system to get the benefits over time,

8:20 which in theory sounds good, but it's probably not going to be the best over the time. Now let's look at side effects. So with Nodak, we have the most common side effect that I hear from people with this is injection site reactions, meaning that people will get a ring or little red hives or itchiness or soreness around the injection side, which is typically in the subcutaneous fat of the belly. Obviously any growth hormone peptide or growth on itself can cause water retention depending on how you're living.

8:54 There's also a sense of nausea or dizziness that can come from it. And a lot of people experience that carpal tunnel. Again, if you have like prolonged use, prolonged elevation of growth, hormone, even if it's with no deck could be something. Usually that's from the dose being too high. And then obviously like as with any growth hormone, there is yes, the potential risk of insulin sensitivity issues with, you know, too high dose or too frequent a dose of growth, hormone peptides like CJC, no DAC, but they're also too potential for an increase in prolactin.

9:26 All this very rare and you don't really hear about it. I think a lot of side effects people associate with that are really just more the water retention. Um, and they're not super low body fat to begin with. And so they get the water retention. They're like, Oh, that's raising my prolactin and giving me gyno. It's really like a, it's just really water attention in my opinion. Now let's look at DAC. So obviously it was going to be much the same. However, the one retention again is going be prolonged because levels are elevated for longer instead of in burst.

9:57 I would say a higher incidence of insulin resistance because of the elevated levels instead the spike, which the body is naturally used to. Again, carpal tonal, same thing with prolactin. In this case, maybe cortisol too, because you elevate it long enough, you could potentially have some cortisol issues. Sleep disturbances, I think Your potential for sleep issues are much higher with DAC than without DAC. You can have joint muscle pain, which again goes back to the carpal tunnel issue. I put tumor growth on here.

10:29 But if that was something you wanted to avoid, so if you're specifically doing your best to a void tumor, growth, you definitely wouldn't want to use DAC and then obviously there's the injection site reactions. Now, the one thing with DAC is people typically have less of an injection-type reaction, but sometimes people get, I've heard of swelling or lumps at the injection site. So who knows? It's one of those things, there's like a thousand different responses any one person can have to any one peptide to take it one time, depending on whatever's going on in their body.

10:59 So it's all over the place, but obviously there's both, you know, your typical side effects you're going to see with a growth hormone peptides. But in contrast to each other, the no DAC version is when you have typically shorter lived milder side-effects Um, and then with the, with that version is going to have prolonged cumulative side effects. And again, that just goes to the nature of the half-life. If you have something in your body that has a very short half life, the side-effects and symptoms are going be however long that drug is in the body. It has very prolonged halflife like CJC with DAC does, then you're just looking at longer symptoms and you add those up over time and the symptoms can

11:37 compound upon themselves, uh, over times. So. you know, it is what it, but I don't want to scare you too much with those side effects. It's not something that's like huge risk, obviously you can kind of see like what your side-effects would be depending on the peptide version that you use. So let's look at CJC, no DAC dosing practices. Typically what you're going to do is a hundred micrograms per injection. I would usually recommend at least two injections per day. Once in the morning fasted and once before bed fast. You could also do it around a workout. If you were doing a resistance training session, you could do around then.

12:07 Um, timing, I would say, you know, again, pre-bed is the best. Um post-workout is a good one. And then, obviously that third one could be, uh, fast in the morning. So just kind of depends on your daily schedule. Now I'm going to talk about this a little bit later on later slide, but, no DAC is often combined with Ipamerelin around a hundred to 200 micrograms. to create a synergistic effect that amplifies the GH pulse, and they can also be administered in the same syringe. And oftentimes you will find them in a blend that they already come mixed together in peptide bio.

12:38 Typically you're going to use this for 8 to 12 weeks, then take 4 to 8-12 weeks off, however long you need to, a lot of times get the water retention off. Usually it will come within a few days or a week. But at the end of the day, dosage wise, you just want to make sure you take this in a fastest state. The growth hormone peptides, because we want make that they are crossing the blood brain barrier to have the full intended effect on the pituitary gland, it's going to be more important that you time those up with being in the fastest stage than some of other peptide that don't necessarily work the same way.

13:14 I think all peptides are better to take fasted, but again, it's one of those things. If you're trying to cross every T and dot every I, that's what you want to do. Now let's look at CJC with DAC dosage. So typically it is going to be one to two milligrams per week, and this is gonna be split up into two to three injections. A lot of times people do like 0.5 milligrams or 500 micrograms three times per a week is a common dose. Again, the half-life is 8 days and so the thought is that you're going to elevate levels all the way.

13:48 And again, it's a little bit less important to time up DAC properly when we look at timing because again it has such a long half life. But you definitely don't need to use it twice a day the that way you would no DAC. You know, this can also be paired with ipamarylin, but if you're going to do that, I would say use ipameralin daily. So don't use it only two to three times per week because it's really not going do anything because that also has a shorter half-life. And again, kind of the same thing with the cycle duration. 8 to 12 weeks off.

14:20 And then obviously too, when you're doing this, I think if we're looking at like any differences in the best practices, live insulin control because it is one of those things that you could potentially, if you have elevated levels for long enough, you know, 12, 16, 20, 24 weeks, uh, You could probably run into some blood sugar issues the same way you would run in to them. If you were taking too much growth hormone. So again, not like a huge issue, but just something to be aware of. Now, looking at Hippomerelin. So I did want to do a slide because a lot of people, even veteran peptide users, they don't know why CJC Nodac is oftentimes a mix with Hiippomerelin.

14:55 A lot times they just see it as a product or something like, oh, I'll buy that. Why buy when I could just buy Hiipomerealin? It's two for one, right? So I wanted to explain why, and then you can make an informed decision as to what would be best for you. So CJC without DAC is an analog of GHRH. Obviously, an Ipramelin is a growth hormone-releasing peptide that works by inhibiting somatocetin. Remember what I said earlier, we're looking at inhibitting somatoacetin, this prevents the natural inhibition of gh release.

15:25 Basically, the body does not want to release a bunch of Gh because the bodies always shooting for homeostasis. But by blocking somatostatin with ipamerelin, it allows CJC with Nodac to trigger larger and more consistent GH pulses. So CJ C stimulates GH release whilst ipamerelin reduces somato statin levels. And this results in a stronger, more frequent growth hormone release. The combination leads to higher growth among peaks than either peptide could achieve on its own.

15:55 So you'll get a certain amount with Hippomerelin, you get certain amounts with CJC. When you use them together, it's kind of a one plus one equals three effect. Again, I'm not recommending that's what you do. It's just kind like what do you want to do? People get great results with hippomerelin, people get results CJT by itself, but you can use it together if you like. I know a lot of people like using them, together. Basically, a CJC with no DAC is designed to mimic the body's natural pulsatile release of GH, and then Ipamralin lowers the somatostatin levels,

16:26 consuring more consistent GH releases when paired together. And also too, when we kind of look at these, it kind minimizes the side effects of each because we're not having to take a higher dose, which may result in more side-effects. And so we are kind minimizing the effects while maximizing the output. So hypermerelin is selective in action and avoids a lot of the sides effects like increased cortisol, prolactin, and hunger. CJC combined with hypermerlin increases the amplitude of GH pulse without unwanted side effect.

16:56 That being said, I think more people struggle to deal with sleep problems in the initial phases when they use both of these together than either one in isolation. And people that tend to use Ipramelin alone, sleep amazing. Then people who use CJC alone may have some sleep disturbances, but when you use them together, a lot of people are like, oh, couldn't sleep when I was on this and this is often why. again, because it's so strong of a GH pulse, which you would think will lead to more sleep.

17:27 And maybe that I don't, I'm not saying that's what's going on, but I do think that when you use both of these together, it so it strong that it kind of affecting metabolism in a way that can impair sleep, so who knows, We also get long-term benefits with short-acting peptides. So CJC obviously is a very short acting peptide that mimics natural GH secretion. We pair that with ipamarylin. It triggers natural sharp GH pulses preferred by some users for maximizing the benefits while maintaining natural rhythm in the body. So if pituitary, you know, like effect on the pitutary or feedback loop on pituatory to shut it down, whatever they are,

18:04 this is really just mimicking the bodies natural pulse. We're not really in a way having a strong effect, on a pituity gland to cause it to shutdown its own natural production. And so when we pair Nodak with Ipermrelin, it creates one to two injections per day for optimal GH release. And a lot of times if you use both of these together, you don't need to do that third injection per-day because it's going to work better when they're combined as far as the half-life goes. So what I did lastly was just said, which one is right for you? So I can't tell you that, but I kind of tell what would be best for in these circumstances.

18:40 CJC with DAC is for you if you prefer fewer injections. You want elevated growth hormone levels throughout the week. Um, you want more of those like long-term benefits. So you like, maybe you have an injury and you wanted to like have growth, hormone elevated to help with repairing the injury. That could be a good use case for that. Um, and you don't mind the water retention or reduced insulin sensitivity. So it's like one of those things, like if you're trying to get shredded, you not going to want water attention, but if have a broken foot, You may want to increase growth hormone in the body to help that foot repair.

19:12 And you are not really worried about water, retention in that case. Conversely, without DAC, CJC 1295 without DAC is good if you want to mimic the body's natural production. You want more controlled injections so you're more anal retentive like myself and you don't mind injecting one to two times per day to be very precise and accurate and kind of time those growth hormone peaks up right. And then also too, if want the more natural approach to how the naturally produces growth hormones, I would go CJ C without that. So if So really they're just looking into like full scale optimization.

19:45 I'd probably go with no DAC because you're really mimicking the body's natural production, which again is going to, in the long run, lead to less side effects and I think vastly improved outcomes, but you know, people could argue not. In summary, CJC with DAC is best for those who prioritize convenience, want sustained GH release, and are okay with a less natural growth hormone pattern. And then CJT without DAC, the ideal for that is we want natural GH pulses, don't mind more frequent injections, that are looking to maximize growth hormones peaks with greater control over timing.

20:16 So that is it for the slides. And that's my full scale onslaught of an analysis on CJC, Nodak and CJ with that. So hopefully that clears things up for you guys. Even in the research of doing this, even though I knew this just in my head, it was good to go through this kind of refresh it because Um, it's not something I look at, but there are a lot of people that use these and rightfully so in their starting journey with peptides. And, um, hopefully, like I said, this is a back to basics video to kind of remind you where they're at. Even though I use human growth hormone itself, I still think that you could use.

20:49 Um. Appropriately. I think people are, these are like the gateway peptide, you know, if I'm relevant, CJC, BPC. These are the ones that like really get people into peptids. and, uh, and I, think it is crucial to have this information out there and hopefully this kind makes your decision making more informed and more fun. So hopefully this was helpful. Definitely let me know what you guys' thoughts and feedback below if this is helpful, if you like these videos to keep cranking them out. And then obviously too, don't forget to check out, I have a link in all the videos and on my email list of video topics or suggestions.

21:20 Uh, so I use those to make my Q and A videos. I definitely do those because I see all those, although I can't respond to every email and comment I get, but I do see those and I absolutely use them. doing my best attempt to formulate content that is optimized for you guys. So much love out there. I appreciate everyone. And I will talk to you in the next one. Peace.