GHRH vs GHRP: How to Stack Growth Hormone Peptides

0:09 Hey everybody, this is Hunter Williams. I hope you're doing amazing wherever you might be in the world today. Think I have a pretty cool video today, it might a little bit more elementary, but I think it's actually valuable for even some veteran peptide users. What we are going to discuss today is the difference between a GHRH, which is a growth hormone or releasing hormone and a G H R P, I think when it comes to peptides, probably the class that there's more confusion about than others because we really have a lot of options in this class

0:41 is the growth hormone peptide's class. And there are a lots of companies that sell a bunch of different blends that make it even more confusing because it's like, well, I can get four growth hormones peptids in one blend, why not use them all, right? And so today I don't claim to be the definitive expert on anything. I give you my advice, my personal experience, and I gave you the experience I have from working with a ton of people What I'm going to do is set up the difference between the GHRHs and the ghrps and explain what you may benefit from blending together and then what You may not benefit From blending because

1:13 they might be really the same thing and it would be redundant to Do so and I think it Would be easy to just say hey these are the Ghrhs use these these Are the ghrps use These or stack these but I want to set Up the Difference between them and how they're working because I Think when we understand why It makes it a lot more fun to understand the process behind doing something so that we can choose accordingly based on whatever our goals may be. So that's what we're going to talk about today. Before I get in, thank you guys so much. Just a reminder, make sure you're on the email list.

1:44 Censorship is ratcheting up. And if I get deleted off any of the other social media platforms that I am on, that is the best place to stay in contact with me to state up to date with wherever the new content that have to publish will be because I plan on doing this for the rest of my life. And the great thing about being on the email list is in the footer of every email, I have a link to all my old videos, to the ones that were deleted of YouTube. You can go watch those for free. you can download them, you could share them with your friends, You could do whatever you want with them. So that's another benefit of being in email lists.

2:14 I had that link in there. Alright, without further ado, I'm gonna share my screen and today we're gonna learn about GHRHs versus GHRPs. Alright let's get into it today. We're going to be looking at GH-R-H analogs vs. GH RPs specifically for anti-aging and longevity, which is probably what you're using them for. Now explaining these, we're gonna first look at the mechanisms of action. We have two distinct pathways. GHRH analogs and GHRP's were completely different receptors and signaling mechanisms to boost growth hormone.

2:47 Each approach offers unique advantages, and when combined, they create powerful synergistic effects that maximize GH release beyond what either can achieve alone. And I think by the end of this video or presentation, you're going to have a good understanding of which ones you may want to use in your routine. Let's first look at the GHRH analog. That stands for growth hormone releasing hormones. Let's look at first how they bind the receptor. So GHRH analogs mimic natural GHrH binding the GHrh receptors on pituitary somatotroph cells.

3:22 From there, they activate and trigger a GS-coupled GPCR pathway raising intracellular cyclic AMP and activating protein kinase A, otherwise known as PKA. We also get a calcium influx so the pKa activation leads to increased calcium in flux in the cells preparing for hormone release. And then we have the growth hormone lease. Then stored growth hormones is secreted in a pulse while GH gene expression increases over time. Examples of this, the primary ones we're going to be looking at are CJC1295 and Testimonellin.

3:55 Sarah Morellen would also fall into this category. I don't really talk about it or don' really put it in the slides because to me, these two, the CJC and the testosterone work way better. And people ask me I get two or three emails every single week. What's the dosing for Sarah morellen? Why is it not on the cheat sheet? The reason it's not on the cheat sheet is because these are way better at what they do. The reasons that sermorelin is not in the cheatsheet is that we have things that are better that the same price or cheaper, then you would get sermarelin for it.

4:25 If you want to use serbarelin, that's totally fine. There's a use case for everything. I know some people that love serrarelin. But it is kind of like saying, why is vitamin C not a cheat-sheet? Well, first of all, it isn't a peptide. Second of, all it not relevant to the context of what we are doing because we had access to so many better things. And again, no hate towards Ceremorellin, but it's just the reason I don't put it on there. Now, let's look at the GHRPs because they're slightly different. GHRP's are synthetic ghrelin mimetics that bind to the growth hormone circretogog receptor, GHSR-1A, which is the ghrelin receptor.

4:57 They stimulate GH release via a different signaling pathway than the GRH analogs. The GHSR activation engages GQ and phospholipase C, increasing IPDAG and intracellular calcium, activating protein kinase c. This triggers GH exocytosis and reduces somatostatin stone, amplifying GH pulses. The ones that we would categorize this are GHRP6, GHRP2, and then Ipamrelin would be the most common one.

5:29 MK677 is also one of these, although I didn't include it just because I'm not a huge fan of it. There is a compound called MK777 that I like a lot better than 677, but the verdict is still out on that just cause we don't have a lotta data on it, And Ipamrelin is a highly selective for GH without affecting other hormones, whereas GHRP6 and GHRP2 dramatically increase appetite and the older GRHRPs can stimulate ACTH and cortisol. Like MK677, that's another side effect.

6:00 MK677 stimulates prolactin and cortisone and can raise those, which is not good. Whereas Ippamrelin does not do that. Now, when we look at the synergy of pathways, we have the GHRH pathway and the JHRP pathway, and we combine those together we get amplified GH released. One plus one equals three in this context. And because GH-R-H and GHRP's act on distinct receptors and signaling pathways they produce a synergistic effect on GH release. GHRH primarily increases growth hormone synthesis and primed somatotrophs via the cyclic AMP and PKA pathway, while GHRP's powerfully trigger release of

6:38 GH vesicles through the IPCA2PKC pathway. A lot of fancy scientific words to say that they work via two different pathways to increase growth hormones. And so when we use them together, it's actually going to have a synergistic effect. Now let's look at the pathways to the GHRH analog pathway acts as a pituitary GHH receptor stimulating adenylate cyclase cyclic AMP PKA activation GH gene transcription and hormone release. This promotes new GH synthesis and the effect depends on somatotroph sensitivity and is often given when Somatosatin is low.

7:12 And then we look at the GHRP, which would be ipamrelin. It binds to the GHSR1A on the pituitary and hypothalamus, activates phospholipase C, then PKC and calcium release, and it triggers transient somatosatin suppression and can stimulate GHRH neurons, amplifying the overall GH pulse. Now, let's look at the duration of action. They can differ significantly in the half-life and GH pulse profile, which affects dosing strategies and physiological effects. We have the short-acting GHRH analogs, Which are going to be seromerilin and CJC.

7:43 they have a rapid short lived action with around 30 minute half life, what causes a quick GH spikes within minutes. And this physiologically replicates natural GH pulses. So this is very similar to the natural pulse. Then we have the long acting GHRH which would be CJC1295 with DAC, and this binds to albumin which extends the half-life to around one week, this yields sustained elevation in the GH and IGF-1 over days versus without DAC of CJC, which is short acting.

8:15 Now, I personally don't like this because if you elevate IGF-1 per day, you can get water retention, and you get some effects, versus the CJT, the Cermerellum, they're going to have a short spike which has the pulse that we want, what gives us the effect we wanted. Ironically, we'd want a pulse of it because the downstream effects happen better and then they clear the system when we have that pulse. Then we got the GHRPs. They have short half-lives of minutes to hours. Ipermen's half life is around two hours, while GHRP6 and 2 can have very acute GH spikes with a half of less than 30 minutes.

8:46 There are often dose multiple times daily to maintain frequent GH pulses. Now let's talk about the wellness and longevity applications because what we want to do is enhance the body's natural GH pulsatility while maintaining feedback mechanisms. We look at improved sleep quality. Many users report deeper, more restorative sleep when using GH releasing peptides, especially with nighttime dosing. Physiologically, GH is tightly linked to slow wave deep sleep and GHRH activity promotes slow wave sleep.

9:16 Studies confirm that exogenous GHRH enhances slow-wave sleep in humans and GH secreticose like MK677, we just don't have data on it because it hasn't been really studied in human. But MK677 significantly increases REM and stage 4 sleep duration in both young and elderly adults and by boosting nocturnal GH which naturally spikes during sleep, GHHs and their analogs, leads to better sleep architecture with more time and deep sleep and REM, translating to improved recovery and daytime energy. When we look at fat loss and composition, Tessamrelin is going to be the strongest when it comes to fat-loss, but growth hormone itself is a potent lipolytic

9:53 hormone that mobilizes fat for energy and helps preserve lean mass. Increasing growth hormones through sacroiliac aids and reducing body fat, particularly visceral fat over time, We look at Tessamerelin, which is a GHRH. It reduces visceral adipose tissue by 15% in six months in studies. And the dose for that was two milligrams. Now you might not need to go that high. You could do 500 micrograms, you could one milligram. I always tell women to start on the lower end because they tend to get a little bit of a bloating from Tessa more so than men. And obviously testosterone is FDA approved to treat HIV associated abdominal fat and elevating GH and IGF1 via these peptides improve muscle to fat ratio

10:30 by promoting fat breakdown. And they also have mild anabolic effects. Users of CJC and epimelan stacks often observe gradual decreases in fat mass, especially when combined with diet and exercise. Attributable to higher lipolysis itself. When we look at skin health, obviously increasing growth hormone helps with collagen production. It also helps cell regeneration through IGF-1 by promoting cell proliferation and collagen synthesis in the skin. Also upregulates type 1 collagen and elastin, mRNA in skin cells. And this usually leads to visible results.

11:00 So people notice more skin hydration, better texture and healing of minor wounds, which leads Overall, better appearance. We look at muscle strength, recovery, and repair. Users experience improved workout recovery with faster healing of micro tears and potentially reduced injury downtime. There's less muscle soreness and quicker healing that are commonly reported. You also have tissue strengthening, so increasing growth hormone aids, tendon and ligament strength via collagen deposition. which assists in strengthening joints and speeding wound healing. It also supports bone density and joint resilience in aging individuals.

11:33 And then we do see lean mass gains. A sacroiliac protocol over months can modestly increase lean-mass and strength, especially when paired with resistance training while maintaining physiologic GH pulsatility. And when we talk about this, we are looking at physiologic doses because the thing about the peptides is you it's very hard to achieve super physiologically levels with the Peptides versus using exogenous growth hormone. I'm not going to talk Exogenous Growth Hormone in this video because it is not really for it, but The downside to these is very,

12:06 very minimal. And it works good in young adults, it looks good and old adults. Sometimes older adults do better with HHH supplementation of the actual hormone itself. Nonetheless, these are relatively safe for what we're talking about at the doses that we were talking Now, what I want to do is put this into a chart so you can see it and if you wanted to screenshot the video. So we have CJC Nodac, which is a GHRH, half-life of around 30 minutes, the dose is 100 to 300 micrograms. This is the short-acting GH pulse, often stacked with GHRP's.

12:39 When we talk about this, we want too stack a GHR-H with a GRHRP. So do you want to stack CJC with Tessamerelin? Not really, because they're doing the same thing and hitting the pathway. So you're using two different chemicals to achieve the result. One a little bit more stronger than the other, but what we would do is pair CJT with it. CJC with Tessamerelin, we're not going to pair Samerellin with CJT, when I compare Samerillin and Tessemerellan, We would pair those with Ipermellin because

13:11 they're different. Then obviously we have Ipermerellen, which is the GHRP with a longer half-life. And so when we put those together, getting the pulse plus a little bit longer, half life that is working in our favor to get what we want. I also want to talk about CJ C with DAC versus without DAC. With DAC, the half-life is around six to eight days, depending on how fast you metabolize it. You inject it weekly or twice a week. This can sustain IGF elevation, which in a lot of cases is not the best thing that you want. Some people want it, I personally would not want, whereas the CJC without DAC has a short half life.

13:42 And then we have tessemoreline. Tesse moreline is a full-length analog resistant to dipeptidol peptase 4, remaining active long enough for a once daily dose. A 2-milligram injection leads to markedly high GH and IGF1 rises throughout the day with targeted indication for reducing visceral fat. And CJC without that is a shortened GHRH fragment with four amino acid substitutions for stability. It must be dosed more frequently, but combines easily with GHRP like Hippomerelin for synergy.

14:12 And many anti-aging protocols pair it with Hiipomerelin to leverage dual mechanisms for improving sleep, body composition, and recover simultaneously. Now, let's look at Ipramelin versus GHRP2 and GHRP6 and why it's better. Basically, it is because it doesn't raise prolactin and cortisol, and it also doesn t really affect our appetite as much. Some people will get an increased appetite from Ipramelin, but not everyone does. It is designed for high specificity, so Ipromelan triggers GH release without significantly raising cortisol or prolacin with minimal appetite effect. provides clean, isolated GH pulse as effectively as GHRP6 minus the undesirable hormonal effects.

14:48 GHRP6 was the first generation. It's highly effective at releasing GH but non-selective. Powerfully induces hunger via the ghrelin receptor and can transiently elevate cortisol and prolactin. and extreme appetite makes it less ideal for fat loss goals. If you need to eat and you are struggling to either you're underweight, GHRP6 is great because it will make you hungry and it makes you hunger in a very short window. Or if for whatever reason you were going to the buffet and just wanted to take down a lot of food, you could take GHRP6 and raise your hunger. GHRP2 was second generation, it was modified for potency, so it induces GH release comparable or greater than GHRP6 at similar doses with slightly less

15:25 epilate simulation. It can still influence cortisol and prolactin levels, and it has largely been replaced by ipramelan. And ultimately, ipamelane for the GH RPS is going to be the best one, in my opinion. But ultimately, it's just about choosing the right peptide. You want to look at the balance between the GH amplitude, which is how high the pulse is, and the frequency. If you're going to use a GHRP, use Ipameralin. if you are going use GHRH, you use CJC or Testimeraline. And if your going combine them, make sure it is a Ghrp with a GhRh. So don't combine CJc and Testimalin or Ceramerolin.

15:57 Use those alongside Ipramuralin To me, the strongest pulse that I see is testosterone with Ipamrelin. That is strong. You will feel it, you will likely be stronger, You'll likely have bigger muscles, and you'll probably get some water retention. you don't need to pair testosterone and Cjc all together though. that's a blend that i know a lot of manufacturers make, And you do not need all those together. If you're going to do anything, I think start with CJC and Ipmrelins first, then use testosterone. But all this together, I always recommend, when we look at all this together, use these in isolation before you use them together.

16:35 Use CJC by itself before use CJT and Ipamrelin. use Ippamrellin by yourself before using it with Tessamrelin or CJ C. Why? Because some people don't respond to them well. Some people hate CJ-C because it gives you a flushing effect and can also raise heart rate in some Some people hate testosterone because it makes them bloated. So they're better off with ipamrelin or ipamarelin and CJC. But if you're using a blend of two or three of those, you are not going to know what you like and what don't like.

17:05 And then when you go to combine them, your not gonna know whats working and whats not working or what's causing a bad effect and if your haven't used them in isolation before. That's my recommendation. If you're new to the peptide game, use all of them in isolation first, see how you like them and then go and you can use a combination of. But I think the combo, the best combo is probably the Ipamelan and the CJC. This Testamelin and Ipermelan is going to be really strong. So if you are bulking, that might be a good thing that you want to do. For me, a lot of times I'm like, man, I get so bloated.

17:35 My face looks like the Michelin man if I am doing that. And so it's not the thing for me. And then you can get into dosing. There's so many different dosings strategies that you could talk about. But typically, ipamrelin and CJC together, 150 micrograms of each together is like one dose. And if you were to do testamrelin and ipamerlin together usually like 500 micro grams of testamerin, and like 200 of ipamarilin tends to well, 300 of A lot of manufacturers make them at a three to one ratio. So it'd be like 600 micrograms of testamerelin and 200 micro grams of ipamerelin.

18:08 I like the ipamerelin and CJC at one-to-one dose. Some people will do higher on the IPAMERELIN and lower on CJCs. It's really up to you at the end of the day. But before you start mixing them, the best thing to do is use them in isolation. And even though they are working different pathways, before get to that synergy point, you're going to know which ones you like and maybe which one you don't respond best to. We look at administration, obviously all these are sub-Q injection. Just a reminder on timing, they must be taken on an empty stomach, no food for around two hours before or after, because elevated glucose and insulin can

18:41 blunt the GH release, thus rendering the peptide less effective, not totally ineffective, but much less affective. And common schedules include before bed for overnight GH released and possibly once in the morning. I like nighttime dosing the best. You could do both if you want to. Some people they feel too stimulated from taking it at nighttime, so they take it in I sleep so much better when I take it at nighttime. So that's why I like taking nighttime and it's up to you. But like I said, one to one ratio is usually the best. And then we look at doses. CJC, the typical dose is 100 to 200 micrograms.

19:12 Testimone, that FDA approved dose, is two milligrams, but you can do 500 micro grams. You can one milligram. A lot of guys do well on one milligrams. a lot females do on 500 micrograms, But if you want to be really aggressive, you could do 2 milligrams You tend to see a faster antibody buildup at the two milligram dose, meaning that if you use it for four to six weeks, you'll probably notice it start working less effectively. At the time, it's not that it is not working. And then Ipamelan dose is just 100 to 300 micrograms per dose. Commonly two times per day. And what you will notice is improved sleep, enhanced recovery, and just overall better well-being.

19:48 And I think whether you're using growth hormone by itself, or you just want to use peptides, you can mix and match these with growth hormones to get even a better effect. I still will use the growth-hormone peptide periodically throughout the year just to cover my bases from a pituitary standpoint to keep that stimulated the same way a lot of guys use HCG alongside their testosterone. That is it for the slides. And that is the comparison and contrast of GHRPs and GH RHS. To sum that up, when you're combining these, you want to make sure that you are using a GH RH with the GH RP.

20:22 You don't want combine, in most cases, what people would be doing, which is a G H R H together. you definitely don' t want t combine a J H RP as well. I didn't say that, but you don t wanna combine it from L N with like MK 677 or GHRP 2 or 6. You want to have the GHRH and the GRRP working synergistically together. If you want the more conservative approach to that, it would be IPRELIN with CJC. if you wanted the aggressive approach, that it will be the TESMORELINE with IPRLIN. But there's no need to pair TEMORELEIN or TESSMORELINE You don't need to do that.

20:58 You would want to pair those with a GHRP. I guess you could get into the permutations of like, Hey, you can take MK six seven seven with Sarah Morellen, right? Because that would be a GRP with GHRH. H you. Could take M K six, seven, and seven. that would be a good pair. I wouldn't recommend that. You'd probably look like a water balloon, but think about that when you're stacking these, what's the GHRH? What's a GHRP? If I'm buying a blend that has Cirmerelin, Ipamerein, Tessamerelin and CJC altogether, am I really doing myself any good or am i just wasting my money

21:30 and potentially overstimulating that one pathway to where I don't need to do that? And I think when we look at cycling these, I like doing those in isolation first, because one, not only are we cycling peptide chemicals so that the body sees it as a certain drug that it's using, we're also cycling pathways. So if you do ipamrelin for eight weeks and you love iparilin, then you can switch to CJC, and your stimulating a different pathway to get growth hormone a difference way, while building back up a sensitivity to ipumrelon.

22:00 You could do it longer than eight-weeks, it doesn't have to be eight week, but we are looking at a typically won't respond better when we come back on the peptide if it's been through a different pathway. So you could literally go from Ipamrelin to CJC to Tessamerelin, eight weeks, and then do that two times per year and get pretty good results. But maybe you want to stack Ippamrelin with CJT and you can do it for eight or 16 weeks and go to And so it gives this flexibility to operate within this framework. At the end of the day, I'm not going to give you like a cheat sheet for that because you have to decide what works best for you.

22:32 But just remember when you're doing this, don't stack GHRHs together, Don't Stack GHRPs Together. You wouldn't need to take Ipermeralin with an MK677. I mean, i guess you could, but it just wouldn' t be the smartest thing to do the same way that stacking Testmeralyn with Cermeralen wouldn t That's it for this one, hopefully that made sense. Hopefully it was helpful and educational and informative all at the same time. To you guys, I look forward to the feedback in your comments. You can leave comments on Spotify and I definitely will read and do my best to respond to all those right now. So thank you, guys so much. I appreciate you.

23:08 liking commenting subscribing sharing it with a friend getting this information out there it helps make the world a better place and hopefully helps me and for that I am eternally grateful for you guys and I have so much gratitude in my heart that i get to do this every day it means the World to me that, I get, to help people sharing this Information that. I love learning myself and teaching to you, guys Thank you I appreciate you love you and i'll see you in the next one peace