GLP-1 Diet Disasters Why Your Gut is Suffering And How to Fix It

0:09 Hey everybody. This is Hunter Williams. I hope you were doing amazing wherever you got in the world. Today's video is going to be about gut dysregulation on GLP ones. And I don't know exactly what my title of this video yet. Obviously if you're watching this, it has a title, but I'm thinking something along the lines of GL P ones don' cause gut problems you do in your lifestyle does. I've been wanting to make this video for some time and I finally came across enough anecdotal information and then some research and some personal experiences

0:43 with people that I have talked to inside of communities and everything that led me to making this. Now, if you have been following me for a while or you've already been keeping up with GLP-1 peptides, obviously one of the big knocks against them is that they cause problems with the gut. So they The slowing of gastric emptying, which I'm going to explain, is not necessarily a bad thing. They cause people to have vomiting, they cause to people have constipation, diarrhea, it causes people just basically feel terrible. Now, I think if you are sharp enough to move along down the spectrum of the more advanced GLP-1 peptides like TERS or RETTA,

1:20 You're obviously doing the right thing and you're putting yourself in a position to succeed and not have those issues, but there are still some core behavioral elements that go alongside the practice of using a GOP one that are causing most of the people's problems that they have. on a GLP-1, but there are also some structural things going on the body that I'm going to talk about today in terms of candida and yeast and bacterial overgrowth and all those things. So basically when people have problems with their gut on GLp- 1, they're combining a bunch of different factors that lead them to end up having a disaster happen.

1:59 And what I really want you to take away from this video is that one, GOP ones are really, really good at what they do. It's usually the user error that is causing the problem. So saying that GOPs ones have problems is really like saying, that going to the gym makes you sore. Obviously that quote unquote a problem, but it's an intended consequence of you going into the jam because what happens is you go to gym, you tear down your muscles, they get sore and they build back better. And then you have muscle, which is your metabolic currency that makes your healthier and live longer and stronger.

2:34 A lot of this is taken out of context. I'm not even going to address some of the stuff about people talking about the crazy things with GLP-1s in terms of snake venom or anything like that being in there. If you still think that's true, I would just say I got a bridge to sell you in Arizona, as the old saying goes. But today I really want to examine why so many people seem to have gastric problems on a GLP-1 and I think I will say if you look at the bodybuilding community now that a lot of the building community is coming around to GLp-one use, you will notice for the most part, not all cases,

3:08 but for most people in the community respond amazingly well to glp ones and now There's a ton of bodybuilder influencers and a tone of Bodybuilders that are out there talking about how amazing GOP ones are. And obviously I've been beating that drum for a long time because I, I'd seen them firsthand for years and I have seen what they can do. I will leave you with an analogy before I share the screen that if you look at a bodybuilding community and what their doing with GOPs versus your average human and What they are doing?

3:38 There is a massively pronounced and a disparate response between those two communities. And there's a reason for that, and I'm going to explain why that is today. So as always, if you want the new and updated peptide cheat sheet, go down. I actually just updated it this month, March of 2025. If you wanted the New and Updated Peptide Cheat Sheet, you should be able to go out and download it. Even if already opted in, it should send you a new one. People complain, I usually get five to 10 complaints every single day. of people that can't get the peptide cheat sheet, but it should work.

4:08 Usually that is an error on your email service provider. I don't know whether it's Yahoo or Gmail or whatever that's the main culprit. That link is there. And I know because I usually get four to 500 people a day that download the Peptide Cheat Sheet. And there's usually only one or two or five or 10 depending on the day they complain about. So that being said, check out the Peptide Cheat Sheet and then also hop over to FullyOptimizedHealth.com. It is the best private community on a planet where we talk about these things in depth. And I will say all the people in there, whether they're practitioners, doctors, or biohackers, whatever they may be, they are ahead of 95% of the of people

4:42 out there doing all this bio-hacking stuff. I love the people inside there. That's our community. And I just can't speak highly enough of the People. It's great that Jay and I are there, but really once people come in, they realize that the community is the power and the high vibration nature of The community and high-vibration people we have really make it special. So without further ado, I'm going to share my screen and today we're going To learn why you are the problem. I am the Problem, right? Take responsibility. All right, today's video is all about GLP-1 peptides, gut dysregulation, and the diet.

5:13 And we're going to learn why so many people seem to have problems with their stomach when they're on a GLp-one. So GL p- one receptor agonists, such as semaglutide, turzapotide and retitrutide have obviously revolutionized treatments for obesity. I think that is even an understatement and also type two diabetes by curbing appetite and slowing gastric emptying. Now people usually hear gastrik empting and they think, that's the worst thing in the world, right? Not so much. And again, like I said, it's kind of taking things out of context. I think people associate that with a negative.

5:43 So by keeping food in the stomach longer, these peptides promote satiety, which is a feeling of fullness and weight loss. However, the delayed gastric emptying, a form of quote unquote induced gastroparesis, can create a fertile environment for gastrointestinal dysregulation. So when compounded by a high fat diet like keto or carnivore known to alter gut motility and microbiome balance and pre-existing dysbiosis such as candida or SIBO, otherwise known as small intestinal bacterial overgrowth, the result may be exacerbated GI symptoms, suboptimal outcomes,

6:16 or even apparent treatment resistance. So that's a term now people are GLP-1 resistant and it doesn't work because it causes all the problems. Let me take a brief aside. Well, I'll do that later because I want to address the keto in the carnivore diet, but I think it'll make more sense when I get there. So let's look at the idea of gastric emptying. GLP-1 receptors intentionally slow gastroempting. When people hear, oh, semaglutide or wagovi or azimuthic slows gastroc empting, isn't that terrible? That's what is intended to do.

6:48 That would kind of be like saying how terrible is water for hydrating you? How terrible is it a guard dog barks when people walk by? That's what it's intended to do. You cannot get mad at something for what is was built to. So, semaglutide and similar drugs cause delayed gastric emptying, like we said. This is obviously dose-dependent. The effect of gastroc empting, one, is dose dependent. and more pronounced early on in the therapy, as patients suggest. So they often experience nausea, satiety, bloating, and constipation, which are hallmark symptoms of slow GI transit, Which just means slow movement of

7:23 food through your stomach. In fact, recent reports have linked medications like SEMA and TERS to cases of stomach paralysis in susceptible individuals. I'm going to explain who those susceptible people are. and clinicians are advised to use caution in patients with known gastroparesis as GOP1 agonists can aggravate the condition. Notably, terzapotide appears to slow gastric emptying to a similar degree as semaglutide, and some studies suggest that the gut may partially adapt over time, But GI side effects remain common.

7:55 Now red trutide is a little bit newer. It also does produce dose-related GI effects. In a phase two trial for obesity, the most frequent adverse events with red true tide were gastrointestinal. So compared to SEMA and TURS where that was one of a few different ones. in Retatru Tide, it tends to have lower side effects and most of the ones tend to be mild remodeled. So, RetaTruTide does seem to you have an improvement. But, however, all three of these, if you've used them before, you know they probably have a gastric emptying effect across the class. Let's look at this. I've put together this little chart.

8:26 With SEMA Glue Tides, We have market slowing of gastric emptying and people typically lose around 15% of their total body weight over 68 weeks and the common side effects are nausea, bloating, early fullness, and constipation. Trishaptide, very similar gastrogym being slowed as sema glutein. It will probably, for most people, slow down faster than semaglutide will. And in 72 week trials, there was around a 20% reduction in total body weight. Again, symptoms were common and similar to semoglutar, nausea, diarrhea, vomiting.

8:59 Very comparable. Now with Reddit True Tide so far, from what we can gather from the data, there is going to be significant gastric imping, obviously, because the GLP-1 piece is a component of Reddit true tide. But the glucagon actually may counteract the gastro-gimping minimally. So it tends to have less of effect that we've been able to notice. I would say in practice with myself, I definitely have the lowest side effect profile on Reddit, true time myself personally. And I've seen that in thousands of people out there in our communities and stuff. So this over a 48 week trial so far retitrutide has been shown to create a 24% decrease in total body weight.

9:37 Obviously vastly superior. Just when we look at bodyweight, it also tends to preserve lean mass more than sema or terse. If you're not using retritrutite now, get with the program. I know it's not FDA approved, so some of you guys out that are not going to do that. It does tend to increase dose dependent nausea. So around 45% had a nauseate higher dosage. I would not recommend you to either start or even titrate up to higher doses because you don't need to, but it does have as a side effect, diarrhea, vomiting, constipation. Just to give you kind of how these stack up, retichrutide is going to have the lowest side-effect profile of gastric emptying.

10:11 And we think right now that is because of the glucagon activation that it is doing there. That kind gives you an idea of what's going on now. When we talk about gastric emptying, the fact that these peptides are slowing gastroc empting is not necessarily a bad thing. It's what people are doing that exacerbate the gastroempting that ends up being a good thing for me. I know that my gut motility is a little bit slower when I'm using a GLP-1, but because of my diet, my lifestyle, and my supplementation and everything

10:43 that goes into what I do from a health standpoint. It's not an issue. And in fact, it's a, beneficial thing. So the first component of this, of why gastric emptying is going to be bad, is gonna be the high fat diet. Diet composition, especially fat content, significantly influences GI motility and the microbiome. High fat meals are known to slow gastrict empting via hormonal feedback. So fat in the duodenum triggers colec, colextokinin release.

11:15 That's a very, very long word. I found the research, which pumps the brakes on stomach emptying. So let's look at that. Look at this a little bit closer. A sustained high fat diet can lead to chronically slower transit. So animal studies show that rodents fed a high fat diet develop delayed GI transit. One study noted gastric emptying tended to be delayed and small bowel transit was significantly slowed in high-fat fed rats. In humans, patients often report that fatty foods sit longer in the stomach and can worsen symptoms of gastroparesis or reflux.

11:47 Keep that in mind. Let's look at the microbiome now. So beyond motility, a fat-rich diet markedly alters the gut microbiomes, often called dysbiosis, when changes are not good. High fat intake, especially when coupled with low fiber, tends to reduce beneficial bacteria, increase opportunistic microbes. Now, what does that sound like? High-fat intake with lower fiber? carnivore and keto diets, right? And I am not here to bash carnival or keto people. I think those can be useful diet interventions, depending on where someone is at along their health journey.

12:21 However, I They are the absolute worst, worst worst thing you can do. And we're going to get into that more. But when we look at this bacterial population change, a review of diet and gut flora notes that in both animals and humans, high fat diets decrease bacterial DTs and increase for for mucid, for musicides in the gut. So beneficial lactobacillus and by photo bacterium populations drop. while microbes that thrive, that can thrive on bio and fat byproducts rise.

12:53 So this imbalance has been linked to inflammation and metabolic issues. Obviously we're altering the species of the microbiome, the bacteria, and this, when we are using a high fat diet, this is what happens. We can also have fungal overgrowth. High fat diets can affect the gut microbiomes. Remarkable findings from a mouse study showed that a hi-fi diet promoted an over growth of candida. and high fat fed mice candida became the dominant fungus accounting for around 38% of fungal sequences versus only 1% in standard diet mice.

13:24 In contrast, mice on normal chow had a diversity of fungi. These results suggest that a fat rich diet encourages candita overgrowth in the gut, which is not good. Possible reasons include the loss of competing healthy bacteria and changes in bioacids or a gut pH that favors fungals survival. Let's look at now SIBO. So from a clinical perspective, patients with existing gut issues often notice that greasy, high-fat foods worsen their symptoms. The American Gastroenterological Association notes that many SIBo sufferers find high fat foods can make symptoms worse.

13:59 And then we also have malabsorption issues. So excess fat in the gut may be mal-absorb when bacterial overgrowth is present due to bio acid deconjugation by bacteria, which leads to diarrhea and bloating. Thus, while healthy fats and moderation are an important part of the diet, an excessively high fat diet can slow gut motility and contribute to dysbiosis, compounding the effects of GLP-1 induced gastric stasis. What does all that mean? We take the fact that a GOP1 slows gastric emptying, slows it a little bit so that we become fuller so we don't overeat.

14:29 Good thing. However, now we have people that think they need to do a keto and carnivore diet, or they may just have candida because they eat crappy food all the time. And we're now slowing gastroc empting with the peptide. Plus we are eating a bunch of processed trans fats, high fat diet, whether it's keto carnivore or they're just eating pizza and wings and beer all the time. And then that exasperates the gastric imping that much slower. So it makes it that's much lower. It makes worse. Then all of a sudden we have this terrible, terrible feeling in the stomach.

15:02 This is where people get the nausea. They can't eat and they are having this stomach paralysis. Again, the factors now you see are starting to compound. And this is again, look to the bodybuilding community. Look to average person. What does the Bodybuilding Community not do? They don't eat these nasty, high fat processed foods like normal people do. And I'll just take it aside for a second and say, my father-in-law, who is not the most healthy individual, he would admit that to your face. He has been using GOP1s on and off for couple years now.

15:32 The problem with him refuses to exercise and change his diet. So what happens? He has these terrible side effects. He gets nauseous, his stomach hurts and all these things, yet he continues to shove down pizza and pasta and ribs and every junk food under the sun. What do you think is going to happen when we, once low gastric emptying with a peptide, Two, slow it that much more by increasing the amount of fatty foods that we're eating. And then three, don't exercise to help move food around.

16:03 Then also two, a counter to that would be then we have keto and carnivore people that aren't getting fiber into their stomach. They're oftentimes eating way too much fat, which slows gastrocnemia that much more, would be bad if you didn't have a GLP-1 peptide, but then you put a glp-one peptidine on top of it and it's a recipe for disaster. So let's keep going. Hopefully this is coming together. What I did want to do is take a second to look at candida and SIBO and explain those. Candida, SIBo are two forms of gut dysbiosis that can cause Similar gastrointestinal distress, however, they involve different organisms.

16:36 Candida is a yeast or a fungus where SIBO involves bacteria, often colonic bacteria translocated into the small intestine. So those conditions are characterized by excessive fermentation in the upper GI tract, leading to symptoms like bloating, abdominal pain, gas, and alternating diarrhea or constipation, which again, sounds exactly like what happens when people start semen glutide. And in this case, I will say that Semiclutide, Tritopetide and Retrutide is really just spotlighting the issue that was already there to begin with and bringing it to the forefront.

17:06 So, incebo bacteria proliferate in the small intestine, normally where bacterial counts are low. So this can occur when motility is impaired. Food and bacteria linger, allowing colonic species to multiply inappropriately. Common risk factors include IBS, diabetes-related neuropathy, surgeries that create blind loops, and anything that slows gut transit. In diabetic patients, autonomic neuopathy that impairs motillity often causes gastroparesis and cebo together. So the excessive bacteria consume nutrients and produce gas, which is usually hydrogen or methane, leading to bloating, discomfort,

17:40 and malabsorption. So if severe, SIBO can result in nutrient deficiencies and weight loss. Many patients, however, mainly notice chronic bloated and changes in bowel habits. SIBOS typically diagnosed to be a breath test or small bowel aspirin culture. And then when we look at Candida, it is a normal commensal fungus in the gut, but can overgrow in certain conditions. Candida was recognized in immunocompromised individuals, like those with HIV, steroids or antibiotics, and poorly controlled diabetics. In those cases, reduced immune surveillance allows candida to flourish, causing symptoms similar to SIBO.

18:15 Recent studies show that candita can also affect immunokompetent people with chronic GI complaints, in one report, around 25% of patients with unexplained GI symptoms had candidate overgrowth. So, over growth of candide in the small intestine may provoke bloating, indigestion, even chest burning. And that's the heartburn feeling. And like SIBO, Candida overgrowth often coexists with bacterial dysbiosis. So again, we have a host of issues going on there. But you're probably asking, Hunter, why does that matter in the presence of a GOP1?

18:45 Well, I promise we would get around to it. So let's look at SIBO first. SIBON can either thrive on leftover food substrates in their gut. If gastric emptying is delayed, food stays longer in stomach and proximal small bowel providing a feast for microbes that would otherwise be kept in check by regular peristalsis and stomach acid. So this is why GLP-1 agonists can precipitate or even worsen SIBO. So as one integrative person put it, semen glutide works by slowing down the emptying of your stomach. But if food hangs out too long, it creates an environment where bacteria can thrive, leading to SIBo.

19:18 And I will add context to that by saying that if you are eating junk food, you're going to be more likely to get SIbo in the presence of seman glutite because it is allowing, or whatever GLp-one peptide, because allowing the food to sit there in your longer and fester. However, if you're eating healthy, unprocessed food, you don't have to worry about that. So a recent case control study found that among 1,447 patients tested for SIBO, those on GLP-1 agonist therapy had approximately double the odds of a positive

19:50 SIBo breath test. pretty interesting compared to non-users. So users of any weight loss medication, most of which were GOP-1 based, was similarly associated with higher SIBO prevalence. The data suggests the risk of bacterial growth is elevated in the GOp1 users, likely due to the medication's effect of slowing gut transit. And I will add to that, because this is what these studies don't really evaluate for, that the people are not eating healthy. When you add in a high-fat diet, keto, carnivore, or just processed junk, this what's going to happen.

20:21 Then we move on to Candida. So it's still emerging, but the immune and microbiome shifts may play a role. Some clinicians have observed an uptick in yeast infections, such as oral or general thrush in patients on semaglutide, especially those with prior Candidas overgrowth history. One hypothesis is that GLP-1 induced changes in the gut, which is slower transit and altered pH or bioflow. and improved glycemic control could perturb the normal flora and immune responses that keep Candida in check. However, we don't know this conclusively. What is clear is that Candid overgrowth can be both a cause and effect of dysbiosis.

20:54 So high sugar and high fat diets promote it. And once Candide is abundant, it can further disrupt gut microbial balance and even affect nutrient metabolism. When we look at these together, SIBO and Candido overgrow represent gut dysregulation that may be unmasked or exacerbated by GLP-1 therapy. So if you are on one of these peptides and you constantly have bloating, abdominal pain, and intolerance to eating, you should really first of all stop and then go to, okay, what is wrong with my gut? Because obviously there's something that's a problem here.

21:24 And I've heard multiple people say they found out they had Candida or SIBO or whatever it is, they get the Candidia or CBO addressed. Then all of a sudden the GLP-1 peptide works magic on them because they've actually cleaned up their microbiome. They cleaned their diet and they cleaned everything from a healthy lifestyle standpoint that matters. Now, let's look at how all this comes together because when we compare GLp-2 plus a high fat diet plus gut dysbiosis, this is where it gets really bad. So a high fat, low fiber diet slows gastric emptying on its own.

21:59 And someone injecting a GLP-1 peptide, this can stack the deck towards significant gastroparesis. So fatty foods linger even longer, and fibrous foods may form indigestible bezoars in a slow stomach. Patients can end up with severe nausea and fullness after tiny meals. Bacterial overgrowth further aggravates bloating as food sits, bacteria ferments, And this produces gas that distends the stomach and small intestines. The result is often intense discomfort, reflux, and even vomiting. And such patients may not tolerate escalating their GLP-1 dose to therapeutic levels, thus limiting the treatment's effectiveness.

22:35 This is where we see this GLp-I resistance syndrome come in that we're now starting to coin and see all over the place. Unaddressed gut dysregulation can force discontinuation of a GLP-1, which is not obviously the intended goal. And there's been a lot of experts that have noted that diabetics with gastroparesis medications that slow gastric emptying should be used cautiously or stopped because, again, their microbiome is so dys-regulated. To be honest, when you hear the old saying, like, humans can't have nice things, that's what's going on here.

23:07 It's because people treat their microbiome so bad they don't actually deserve the GOP-1 and the benefits that they're going to get from it. So once SIBO or Candida overgrowth sets in, they can perpetuate motility problems and cause inflammation. Bacterial overgrow can lead to mucosal irritation and a cytokine release, which might further disrupt the enteric nervous system. Fungal overgrowth may similarly damage the mucosa or alter nerve signaling, and the term GOP1 resistance is even being explored in animal models of dysbiosis. So one mouse study showed that certain gut microbiota profiles can induce resistance to GOp1's effects on insulin secretion and gastric motility via a

23:43 nitric oxide mediated gut-brain axis mechanism. Pretty fascinating. In essence, a dysbiotic microbiome might blunt how well GLP-1 agonists work. Let me say that again. A dysregulated microbiomes might, or in my opinion, will blunt, how your GLp1 peptide is going to work, so if you get anything out of this video, understand that. If your gut is not in check, your GLP-1 peptide, you might as well be throwing it away. So in humans, a pilot study found distinct gut microbial signatures in patients who responded well to GLp-2 therapy versus those who respond poorly,

24:16 suggesting that dysbiosis could contribute to suboptimal treatment response, thus an overgrowth of unfavorable microbes. Microbes might not only worsen side effects, but could also dampen the metabolic benefits of the GL1 that help with fat loss. And then let's look at inflammation. So both high fat diets and gut dysbiosis are linked to chronic low grade inflammation, everyone knows that, right? High fat intake can raise circulating lipopolysaccharide levels, triggering inflammation and SIBO can cause elevated LPS from gram negative bacterial overgrowth.

24:47 So this inflammatory cascade in milieu can counteract some positive metabolic effects, a weight loss therapy, and potentially hinder weight reduction or glucose improvements. I wonder what may be happening when people stall out on their GLP-1 peptide after taking it too long. Does it have anything to do with the composition of their microbiome? I'll let you be the judge. High fat diets are also calorie dense. If patients continue an unhealthy diet, assuming the medication will do all the work for them, weight loss will plateau.

25:17 In the worst case, ongoing gut inflammation and malabsorption from SIBO or Candida could cause nutrient deficiencies and muscle loss, undermining health despite weight-loss. So in light, of all of these problems. It's easy to see how a patient on a GLP-1 with a poor diet and undiagnosed seborrheic anemia might have poor outcomes, and we cannot view GL-P1 therapy in isolation. Again, my platform is talking about these and how to use them properly. alongside everything else that we're doing.

25:47 And you can't just say, okay, I'm going to throw in a GOP-1, continue pizza, continuing donuts, to even do a keto or a carnivore diet and think that that's going fix all your problems in life. So let's look at some positive, best practice. Obviously, a supportive diet, and lifestyle is healthy. First of all, protein-rich, fat-controlled diet. This is going be my recommendation. You don't have to adhere to this if you don' want to. But I emphasize that lean protein sources, so fish, poultry, eggs, if you're going to eat dairy, low fat dairy and then lean red meat,

26:19 lean grass fed redmeat, there's a huge, you might as well not even call them the same product. If you look at corn fed fatty beef versus lean, grass-fed beef, for instance, If anyone's out there, this brings up a good point. All of the red meat that I eat is from Piedmontese beef. Go to Piemontese.com. That's where all the meat I get from my house. They have extremely lean, grass-fed beef, so most of those steaks that have no fat, maybe one gram of fat per four or eight ounces,

26:49 but most of the steaks have not fat. So I get all the benefits of red meat without all of that fattiness. But I wouldn't even be concerned about the fat if it's from a grass fed cow. I would however be concern about fat from corn fed cows because it is much higher in omega-6 fatty acids which cause inflammatory cascades that would wreck my body. As an aside, what we want to do is focus on leaner meat, so we don't want a bunch of fatty omega-6 laden meat. We want lean omega 3, if there's any fats, meat with protein. So protein's obviously crucial to maintain muscle during rapid weight loss and also aids to tidy.

27:22 However, we Don't eat fried food. Try to stay minimal fat as possible when it comes to our protein. We want leaner protein now. Yes, I understand that there's certain protein sources like lean grass that beef has a way more micronutrients than lean, grass-fed or lean free range organic chicken. So I would stick with the grass-fed beef. But too much fat at once, this is the problem, too fat once can overwhelm the slow digestive system and provoke nausea or diarrhea. And by keeping fat intake to moderate levels and focus on healthier fats like olive oil, avocado, and small portions, we can reduce gastric distress.

27:57 Also, yes, we can use carbohydrates. Carbohydrates are not the devil. We can moderate complex carbohydrates, so very low carb or ketogenic diets, which are all high in fat, are definitely not best match for GLP-1 therapy. So that incorporate moderate amounts of complex carbs such as vegetables, fruits, and then whole grains. I would say white rice or white potatoes or sweet potatoes are perfectly fine. If the worst thing you do is eat white rice and white potatoes and sweet potatoes on GOP1, then you are going to be good and most likely you're not going have the SIBO and the Candida problems.

28:29 So the reason we want to use this, especially the fruit and the berries is because the antioxidants, the fiber and nutrients that come from them. So in the early stages of therapy, if gastroparesis symptoms arise, you don't need a ton of fiber. And I would also recommend choosing cooked veggies instead of raw veggies because of the insoluble fiber like bran that can aggravate slow gastric impeding. Also too, If you ever look into diet stuff, I've done this before myself and it was, very helpful to my digestive system, which for a better part of my life has been a train wreck, but I say go low FODMAP.

29:02 Just Google low-FOD map, look up low fodmap. That is honestly one of the best things you can do on a GLP-1 agonist peptide is to be in a low fodmap diet. And if you do that, you're going to pretty much all right as far as what I understand to use that and I pretty much adhere to that more or less 90 percent of the time anyway but each person's tolerance can differ but obviously we want a balanced diet with carbs from high quality sources so rice instead of french fries sweet potatoes instead Now, let's look at meal scheduling.

29:35 So small frequent meals tend to do better on a GOP1 peptide. Instead of three large meals, eating smaller portions more frequently is a game changer for those on GOPs. And this is where on my eating days, I'm always usually alternating between a fascinating eating day. I will eat four, five or six times and they're usually smaller meals. Smaller meals are easier to empty from the stomach and less likely to trigger overwhelming fullness or reflux. So for example, you might want to have five to six mini meals space throughout the day. This pattern supplies adequate calories and protein without overloading the delayed gastric emptying.

30:07 It also helps maintain steady energy levels. You should also chew your food thoroughly. That's something I got to work on better myself. I was raised in a house with three other brothers and we always were competing for food because if you didn't eat fast, then you You would want to be full. So I will also say one of the reasons people have these problems because they have this garden can't you win meals. They'll have, you know, on a weekend, they'll go and eat like two pieces, two whole pizzas. And then they complain that they're nausea and upset. Again, to get back to the idea of my father-in-law, You can eat two hole pizzas and not think that you're going to have a consequence,

30:40 GLP one peptide or not. But you also want to avoid things like spicy foods, alcohol. Obviously, I don't even go to the conversation about alcohol for this video. If you're drinking alcohol while you are in a GLP-1, you mess it up. I'll say that. But heavy sauces, fried foods can irritate the GI tract or slow digestion further. So it is explicitly advised to limit spicy, greasy and ultra processed foods while on GLp-one therapy. Similarly, carbonated beverages, and this is a thing I don't think people think about this enough, whether it's diet sodas, sparkling water, alcohol, whatever it is, carbinated beverages can greatly increase the bloating and already gas prone system that might,

31:16 those are best avoided in my opinion. I love sparkling, but this isn't something I drink a lot because I know it doesn't do good on the stomach. So I would stay away from it and just use it in isolation. if you're going to use it at all. Hydration is important, but drinking too much fluid with meals can also distend the stomach. So sipping water between meals is preferable to chugging liquids during meals. And I'm a big proponent of this. I don't really drink hardly any water when I am eating. It's usually just between the meals that I eat. If that sounds weird to you, just try it and I promise your digestion will usually improve just from that alone.

31:49 And then we can look at microbiome treatment strategy. So if someone has SIBO or Candida issues, you want to get that looked at. There's obviously antibiotics, there's obvious peptides. You could use LL37, thymus and alpha-1, KPV, VIP, or you could get BioGut Pro from BioLongevity Labs. That will do wonders to help someone that has problems in the gut. I would also look to metformin because that's going to clean up the microbiomes, scrub the And so there's a ton of different things you can look into.

32:19 You can use probiotics, you could use all these different to use. I'm not going to go into that too much in this video. And obviously too, You want to manage the dose. So I think a lot of the problem too is this, is people start off and they feel fine on a lower dose of a GLP-1 and as long as they're improving every other area of their life, they probably going be okay to stay at that lower-dose and micro dose, but I've seen time and time again, doctors, because they are trying to make money. Maybe, maybe not, They will say, okay, after eight weeks you got to double the dose. You got a double dose, you gotta double those.

32:50 And then before you know it, your from two milligrams to 12 milligrams. Then all of a sudden you're running into all these issues and it's like, well yeah, should never be taking 12mg of Trigapatide, Retatrutide and God forbid, Seamuclutide. So again, You want to gradually titrate it for titrating at all and then we're going to use some of these other mechanisms and peptides and lifestyle interventions to hopefully where we don't have to titrated at And then we can kind of, you know, like what I would like to say is blast and cruise the GOP1 peptide to where maybe we're on a microdose. And when we want to get more aggressive with that loss, that's what we move to.

33:21 So hopefully that makes sense. Then just to clear it up, so a lot of times these gut issues the perfect storm. So high fat diets, SIBO and Candida overgrowth can each independently disturb gastrointestinal function and combined with GLP-1 induced slow motility, they create the Perfect Storm for a completely wrecked stomach. Empirical evidence indicates that GLPs can precipitate bacterial overgrowth by prolonging food transit, but this is oftentimes because of the high-fat intake that is causing the fungal over-growth and dysbiosis.

33:54 The best thing to do is adopt a whole food, high protein focused diet with controlled fat intake to where we're not eating a bunch of nasty processed trans fats all the time. We have to pay tons of attention to our gut health. So we want to make sure that we are always addressing good health and making sure, that's a top priority, making that sure we have a healthy, clean, squeaky clean microbiome. One approach holistically, so obviously training, diet, exercise, fasting, all those things are very, very important. in the presence of a GLP-1. They're important anyway, but they should be that much more important.

34:24 And hopefully, for most people, GLp-I is a wake-up call to say, hey, if I'm taking this, I'll be flushing my money down the toilet if not doing everything right at least 80 to 90% of the time. When we do that, we're going to maximize the benefits. So in practice, many patients on GLPs thrive when they eat clean. To bring it full circle, like I was saying, what do bodybuilders not do? They don't eat super high-fat foods. They don't eat junk food. They do not drink alcohol, usually. What do most average people do that are a hundred pounds overweight?

34:55 They eat fried food, they eat processed food they don' exercise, They, don''t change their diet, Don'''t drink enough water, do all those things. So if you look in the bodybuilding slash the fitness world of those people that were smart enough to understand that we can use GLP-1s to enhance performance, enhance longevity, and enhance all the things that you want out of life. they have profound amazing results. If you're looking at the average person, you see all of the complaints and all problems that they had. Albeit they might be losing weight, but they're still having really bad issues. So again, look to those two communities and you can see the pronounced difference in the peptide not being the problem.

35:30 That is it for the slides. And hopefully that was a convincing case of why you are the problem, not the GOP1 peptide. And when I say you, I don't mean you watching this video, but if this was helpful to you I think you could share it with someone that may be using a GOp1 Peptide or is scared to use a GOP1 Pepide because they hear of all the bad side effects. But I thinking the wonderful internet social media land, there's so many people out there now that are saying that GOPs cause all these gut issues and they're not necessarily wrong but they are not taking into the equation that people are eating carnivore, they're eating keto,

36:04 eating pizza, high fat foods, plus they have candida or SIBO, and then they are introducing a GLP-1 on top of it without changing any of those things. So, what's the best thing to do before you ever take a glp-one peptide? Make sure that you have a healthy gut microbiome. I think that's something that everyone should do anyway, but if you had a dysregulated microbiomes and your diet is disgusting, you're going to have problems on a Glp1, point blank period. Is it better than nothing Probably, but you're going to cause more harm than good if you continue to put yourself in situations to fail,

36:39 which would be continued to eat fried food, continuing to not eat fiber, not exercise and diet, continue drink alcohol and all of those things. So hopefully this video stands as a beacon and a light to show you that GOP1 peptides can do good things But only if they're used properly and again, it would be like saying that you don't get mad I don''t get Mad at my dogs for barking at people because they''re German Shepherds They were born to be guard dogs. So when people walk by our front yard With a dog they are going to bark at them and I can't be mad at him for for doing what their program to do and i

37:14 think When we say GOP1s cause gastric emptying to be slowed, that's exactly what they were intended and designed to do. And if you don't want that, you won't have to use them. But I think most people could benefit from them much, much more than they currently are if they would clean up these things in our life. So I would say even from my own experience, I don't eat high fat foods. I usually don' eat more than 50 to 60 added grams of fat a day. And again, too much more of like a bodybuilding type diet, high protein, moderate to high carb, depending on what my goal is,

37:50 but usually moderate carb. and then a controlled intake of fat, which is somewhere between 50 to 70 added grams of day, depending on the day. And I do amazingly well on GOP-1 peptide. I never feel bloated. Like I'm constipated, I've never felt like I have nausea or anything like that. Obviously I am microdosing. When it comes to supplementation and hydration and all those things. GOP1 peptides really are the best medical invention since penicillin, but they have to be used properly and hopefully this video can be one of many among

38:24 all the people out there producing content and moving the community forward and doing research to show you, hey, this is the problem. And these things are bad to do anyway, meaning eating high fat diet, having candida. But if we put a GLP-1 peptide in the presence of those things, it's really just going to spotlight them and exacerbate them, and make them worse. So I would love to hear your feedback on this one. If you have personal experiences, please leave those down in comments just to help people in that community kind of understand this better. And you know, if you had something that you would like to share, I'd love hear that in And I just want to say and close out every video.

38:57 Thank you guys so much for the amazing support. The channel is growing like crazy. It's pretty awesome to see. So every day I'm so excited to get to do this and bring this information to you, guys. And the problem for me now is condensing down the amount of material that I want And then being able to condense it, put forward the research, do everything, organize it properly so that I can bring it to you guys in a digestible format that hopefully is entertaining and educational at the same time. So again, I cannot thank you enough. I am truly honored, humbled, and privileged to get to do what I do every day.

39:31 And wherever you are and however you support, even if just liking the videos, commenting on the subscribing to the channel or then ultimately being on the email list and buying products. That's amazing too. So I can't thank you guys enough. Truly, my heart goes out to everyone out there that supports us in any shape or form. Appreciate you, guys. Love you. And I will talk to you in the next one. Peace.