The Ultimate Peptide Stack For High Blood Pressure

0:09 Hey everybody, this is Hunter Williams. I hope you were doing amazing wherever you are at in the world. Today's video is going to be the peptide stack for high blood pressure. So what I'm going do today is take my best recommendations for someone that is suffering from high pressure, including peptides and kind of give you my thoughts on what would do to help correct high-blood pressure and As it goes with a lot of chronic illness in the world today, I think the most part high blood pressure is actually one that is very easily corrected. So luckily, as compared to other things that are very complicated and have very multifaceted and complex approaches to try to heal them,

0:45 high pressure, at least in my experience and with clients that I work with, is something that is relatively easy to correct. So what I'm going to do today is just lay out my peptide plan for someone that may be struggling with high blood pressure, and hopefully it's able to get you off a lot of the pharmaceutical medication that you may on to help intervene against high-blood pressure. I also know in light of recent events that have taken place in the world in last four years, it's actually something that is much more common now for people that are not obese and I'll let you read into that as you will, but it used to be that high blood pressure was something a lot of obese people had and

1:22 obviously rightfully so because that's a symptom of obesity which ends up leading to cardiovascular disease and things like that. Uh, what we're gonna do today is dump, jump into that and everything. So, uh, before I jump in to that, as always, thank you guys so much for being here. The channel is blowing up and growing a lot lately. Thank you so for that. And what I want you to do is if you are interested in peptides, check out the peptide cheat sheet down below. This is the original one that I created. Now there's a lotta people copying it and which is cool. But check out the peptide cheat sheet to download everything you need to know to get started with peptides.

1:52 But without further ado, I'm going to share my screen. And today we are going learn about about my favorite peptids for high blood pressure. All right. I am Hunter Williams and this is the high blood pressure peptide stack. So let's get into it. Everyone's school is in session. Before I jump into the peptides, I actually just want to talk about what causes high pressure and you probably know, but I wanted to go into this just to kind of help elucidate where we're coming from and what we were actually trying to heal with peptids because obviously no one has high-blood pressure

2:23 because they have a deficiency in peptidies. First, it's going to be vascular resistance. So basically increased resistance due to narrow or constricted small arteries and arterioles. Factors such as vasoconstriction and endothelial dysfunction, which basically just means reduced nitric oxide. We've also got this renin angiotensin aldosterone system, but it basically means that this regulates blood volume and vascular resistance, And basically renin release triggers angiotensin two, which is a vasoconstrictor and aldosterone, Which means we have sodium and water retention.

2:57 Then we the sympathetic nervous system activation. Basically the Sympathetic Nervous System is fight or flight. So when we're activating that, this basically regulates our heart rate, blood vessel tone and blood pressure. Um, so overactivity increases heartrate and vaso constriction and stress response prolongs sympathetic nervous system activation. So a lot of times too, even without obesity, if the body is in a fight or flight state, meaning that you're freaked out and you panicked all the time, which a lotta people are, when you have that for prolonged periods of time it results in high blood pressure in the Next,

3:32 we have kidney function. So basically, the kidney regulates blood pressure by controlling blood volume and electrolytes. And this could include sodium retention and renal artery stenosis. Then also, have hormonal imbalance. I'm going to talk about a little bit of this on the next slide, but basically this influences our blood-pressure regulation. Insulin resistance and high cortisol levels can lead to high blood pressures. Now, what do we know about the modern world today? Most people are suffering from insulin resistance.

4:02 And another thing that they're probably less conscious of is they have runaway cortisol levels. Finally, we have vascular remodeling. So basically structural changes in blood vessels affect elasticity and resistance, and this is where we get arteriosclerosis, which is hardening of the arteries, inflammation, oxidative stress. Basically, our world is set up to make sure that you don't have good functioning blood vessel. What I want to talk about next is basically this idea of Insulin resistance, so we will look at insulin resistance.

4:33 A lot of times when I hear high blood pressure, people are missing the boat that high-blood pressure is often downstream from insulin-resistance, meaning that our blood sugar will be a determining factor, how well we can regulate blood-sugar will a be determining a factor in whether or not we end up with high pressure or no. So basically, insulin resistant contributes to high blast pressure through hyperinsulinemia, which causes sodium and water retention. Basically, you notice a lot of people that are diabetic or pre-diabetic.

5:03 They tend to have problems with sodium and water retention. Also, like we talked about, insulin resistance is going to increase heart weight, which increases vasoconstriction which obviously is gonna contribute to high blood pressure. Insulin resistance reduces nitric oxide production in the body. We're starting to find out a lot more about nitric oxide in the body. And if you want to check out any one, Dr. Nathan Bryan is hands down the best that I know of in world in talking about Nitric Oxide. He's an amazing guy and amazing product formulator.

5:33 You can check it out in O2U, which is going to help with your blood pressure. But reduced nitrous oxide production increases vascular resistance. Then we have inflammation. So insulin resistance leads to inflammation, Which causes chronic inflammation to damage blood vessels. A lot of times if we get insulin resistance under control, high blood pressure will naturally come down. So I want people to understand that, that you didn't get bit with a high-blood pressure bug or a virus or anything like that that caused it.

6:05 It was a symptom of years and years of insulin-resistance that eventually caused high pressure. you can see young people that have high blood pressure and a lot of people are like, oh, he just has high pressure. But a of times this is because they're insulin resistant. So it's not really dependent on age. Now, heart disease, it takes many more years to develop heart that would lead to a heart attack. Uh, but this one of those like leading indicators that we can look at. Insulin resistance is what leads to high-blood pressure because of all those things we've talked about. We can back to those symptoms and understand that those are coming from a person not having the ability to regulate blood sugar,

6:41 which is likely through lack of muscle, lack training, or lack cardiovascular exercise, and ultimately just a lack attention to detail in their lifestyle and healthy living. Let's move to this. Before I talk about any peptides, the number one peptide to help with high blood pressure is going to be cardio. Like I said, I've seen this in a lot of my clients, especially clients in the 50s and 60s. And they're like, I've got high blood pressure. I got all these medicines. And I say, how many hours of cardio a week are you doing? Like, well, walk, you know, and that's unfortunately not going to be enough walking.

7:12 It was great. But I think if someone is doing until someone's doing two hours zone two cardio per week, which would basically just mean their heart rate is between 120 and 140 beats per minute. Um, I don't want to hear anything about high blood pressure. At least that's what I tell my clients that you have no excuse for high pressure until your cardio is in that range. And then once it's not range, then we can attack, we could use peptides to attack it. We can use all these other things, but, um, very rarely do I see someone that has high. Blood pressure is not doing cardio.

7:42 This also kind of goes in the bodybuilder community too. Cause you know, a lot of guys using anabolic steroids or whatever. I know some of them follow my channel. And when we look at high blood pressure, a lot of these guys are blasting anabolic steroids, which obviously through all the things we just talked about increased blood. But they're not doing cardio. And it's like you, even if you're going to do that, like if, you were going take a ton of antibiotics steroids you want to be doing Cardio one, because that's going enhance the muscle development that you have. A lot. don't realize that, but then also too, it's going to help prevent high blood pressure.

8:13 So you don' have to throw in all these other medications that a lot of people do. Anabolic steroid user, or just your average Joe, I would say anyone that has high pressure, look at cardio first. If you're not doing at least two hours per week of zone two cardio, which is really not that much. I mean, that's four 30 minute sessions a week. That is not much, far more than that. Off the top of my head, my, i'm going be somewhere around Probably four and a half hours per week, depending on the week and depending upon my training schedule.

8:43 Um, so two hours a week is really not that much. You can get a very cheap resistance bike to put in your house. Uh, you know, get resistance bikes off Facebook marketplace for like a hundred dollars. People, a lot of times we'll give them to you for free because they're trying to clean out their house so, uh, really no one has an excuse as long as you have a place to live to not be able to do your cardio. And here's the thing too. People say walk walking is great. I walk a lot. But, uh, rarely does walking, unless you're doing it up an incline, get you into that heart rate zone. So if you walk up and inclin, you can get there and that's fine for your cardio.

9:13 A lot of times the walking isn't enough to get in that zone, so that why I say, cardio machines work great, Now, let's look at the peptide. So the first one's going to be trisaptide, and you're like, Hunter, trsaptid is for diabetes, right? And yes, but here's why it helps with blood pressure. Basically, Trisapetide is a GLP-1 and GIP receptor agonist. It basically activates the receptors for GLp- 1 and gip, enhancing insulin secretion and sensitivity while reducing glucagon levels. What did we just talk about?

9:44 High blood pressure is insulin resistant. So basically, terzapotide is going to help improve insulin sensitivity. And by improving insulin, sensitivity, it helps reduce blood glucose levels, which can reduce the cardiovascular stress and eventually lower blood blood. Also, a lot of people don't understand this. This is why I think there's appetites like the greatest anti-aging longevity medicine we have right now. GLP-1 activation promotes vasodilation, which improves blood flow and reduces arterial pressure. So in combo with the reduction in insulin resistance and by improving insulin sensitivity, we're also going to promote vaso-dilation which is obviously

10:23 going help with blood pressure, so turzapetide is hands down my number one intervention and a lot of people go with all these crazy blood-pressure medications and we have something that's like a golden goose right here in front of us to help the blood pressures. The recommended dosage I would start with is just the standard starter dose of 2.5 milligrams per week. So that is why transaptide is important. I definitely want to throw that in there as the first one. Now, BPC 157 and TB 500, I put these together because a lot of times you can get them in a blend. But the reason I have this in here is because most people were like, oh, that's for when I'm, you know, have a, uh, injury or wound or whatever.

10:58 And yes, those do help with that, but let's look at how it relates to blood pressure. Understand this about is that it promotes angiogenesis, obviously, which is a formation of new blood vessels, but it reduces inflammation and enhances endothelial function again. What is in the function was basically how much nitric oxide is moving through the body and how well our vascular networks are functioning. and then also TB 500 enhances blood vessel repair, reduces inflammation and promotes tissue healing. So when we look at that in the context of blood pressure, both peptides reduce systemic inflammation, which helps in lowering blood blood,

11:33 pressure by decreasing the vascular resistance. And then they also promote blood vessels repair and formation, improving endothelial function and vassal health, Both of these, you can get them in a one-to-one blend in most places. You can a 250-microgram dose of each per day. So that would be the minimum effective dose I would need to get started. And that's low enough to, You know, can just inject that subcutaneously and it's going to have a systemic effect that you would. Now that obviously different than the healing dose that I recommend for both of those.

12:04 But for high blood pressure, 250 micrograms per is going do a lot over the course of especially like eight to 12 weeks. Now, MOTC, is a mitochondrial peptide. So again, you're probably thinking where is, where does this fit in the context of high blood pressure? Again, this all goes back to really cellular health and mitochondria health. And it improves metabolic functions by activating the AMP-activated protein kinase, otherwise known as AMPK pathway, increasing glucose uptake in muscle

12:35 cells without increasing insulin. Also, fun fact, Metformin does this as well, which you should always be using, you know, with your high blood pressure stack. But basically, by increasing the glucose intake in muscles cells, without increase in insulin, we're going to help improve insulin sensitivity. So when we enhance insulin sensitivity through the use of MOTC, this is going to lead to lower blood glucose levels and reduce cardiovascular stress on our body. And also too, we look at this oxidative stress. So basically oxidant stress causes aging and chronic disease. When we lower oxidated stress and inflammation in the body, but also more specifically in our blood vessels, it's going promote vasodilation,

13:12 which is basically just the opening of blood vessel,s which are going improve endothelial function, and which will help lower the blood pressure. My blood pressure recommendation dose of Matzi is 2.5 milligrams twice per week. And if you stick around to the end, I'm also going to have a chart that you could screenshot on the screen and everything that shows you, you know, when you would take these and what you take them. Now here is a new one for you and I've actually been doing research about this. I likely will do a whole video about. This because a lot of research places are starting to carry this product now, but it's B733.

13:42 this one sounds even more like a Star Wars name than a love other peptides. But basically B 733 B or B seven 33 is an analog of the human relaxin hormone. So this basically promotes vasodilation by activating the relaxin insulin-like family peptide receptor 1, also known as RXFP1, leading to increased nitric oxide production. So basically, long story short, this is a peptides that helps with nitroxide production, and basically by increasing nitrate oxide It relaxes blood vessels

14:13 and reduces blood pressure. And then also it prevents vascular stiffness. So basically it's anti-fibrotic properties, prevent the stiffening of blood vessel, improving vascular health and lowering blood pressures. Most of these that I have found are sold in six milligram vials. I would do 1.5 milligrams twice per week, and that'll last you for two weeks with the six-milligram vial. That's where I'd start with that one. But very cool, I haven't experimented this one myself. Obviously I don't have high blood-pressure, but definitely could be useful. Now the next one, not a peptide, but one of the also more prominent anti-aging medications that I think should be in everyone's stack for aging is Cialis

14:48 or Tadalafil. So Cialsis is a PDE5 inhibitor and it increases levels of cyclic, guanosine, monophosphate, otherwise known as CGMP, leading to smooth muscle relaxation and vasodilation. And Cialis does a lot of amazing things for the body from a longevity perspective, but as it relates to blood pressure, it helps improve endothelial function. So by enhancing endophelal function, It reduces arterial stiffness, contributing to lower blood. Again, that also promotes vasodilation.

15:18 And you see here too, what I did with this is like a comprehensive approach where we're attacking some of these different pathways. I'm going to talk about in a second, by increasing CGMP levels leading to smooth muscle relaxation and reduce vascular resistance. This is also going to help lower blood pressure. And I would recommend a very low dose. Typically, like most people, we're going use like 15 to 20 milligrams if they're using it for rectal dysfunction. I'd use five milligrams per day. You have to be conscious of cycling on and off of it because you will build up a tolerance to it. But in the case of longevity, you could use it four weeks on, two weeks off.

15:51 Four weeks on, four weeks off. Just make sure you're taking breaks here and there to make that you can stay at a lower dose to get all the effects. Now, the last one is going to be Telmasartan. This is actually a pharmaceutical drug for blood pressure, but it's actually very mild. And this is more from my understanding of the bodybuilding world. I have used this myself just to experiment. Basically Telma Sartin is what is known as an ARB or an angiotensin II receptor blocker. And it blocks the action of angiotensin II, which we talked about earlier, earlier which leads to basal vasodilation and reduced aldosterone secretion.

16:26 And basically what that means is that when you block angiotensins II it reduces the constricting of our blood vessels which lead to lower blood pressure. It also decreases water retention. So it decreases sodium and water attention by reducing aldasterone and secretions which also helps lower the blood pressures. Again, where does that come from? Well, the water Sodium or sodium retention, water retention comes from insulin resistance, but by reducing aldosterone, it's just going to help lower blood pressure. So I say start at 40 milligrams.

16:57 Most tablets come in 80 milligram tablets. Start at like half a tablet a day. And then most people can work their way up to 80 milligrams, so it just kind of depends on what you need. But again, all of this is downstream from in insulin and resistance and a lot of these you would not need once you get your insulin under control. Now, let's talk about the synergy. So I kind of like bucketed here, blood pressure into four different buckets that we're using to approach all these. One, we have the enhanced vascular health. We have BPC and TB, B733 and Cialis.

17:28 The Bpc and Tb is going to promote vascular repair and reduce inflammation. The B733 is going to prevent vascular stiffness and the Cialis is one to enhance endothelial function. The second one was we have the metabolic side of things. So again, our metabolism, so basically Trisaptide is gonna enhance insulin sensitivity, and then Mod C is to improve metabolic function, And then obviously we have the direct vasodilation so we're working directly to work on the vaso dilation of blood vessels. So the B733 is going to help increase nitric oxide production.

17:59 Cialis is gonna promote smooth muscle relaxation and telmasartan is one to block angiotensin 2 and those are all going work together to create vasodylation. And then we have the inflammation. So obviously BPC and TB are going to reduce systemic inflammation and MATC is going lower oxidative stress. When we combine all these together, I think in combination with diet, lifestyle, and obviously your cardio, you're going pretty quickly knock out any sort of problems with blood pressure. And again, this is one of those things as it relates to other chronic illnesses.

18:30 For the most part, it's very easily fixed if you pay attention to it and if your conscious of following a prescribed program. So basically what I did is just put together a little schedule here for you guys. Basically this is what it would look like. I don't need to walk through this because it has all the doses, but I didn't want to put this in there so you could screenshot. You see it's not too much to take over the course of a week relative to any other supplements or stuff you're taking. Uh, so this would kind of be like what the dosing schedule would look like. So trizapatide once a week, VPC and TB 500 every day, uh, MOTC and B, B 7 33, you're just doing twice a weak and then Cialis and Tomasartan,

19:07 and you just do it every. Uh. Very easy to adhere to. And I believe that is it for the slides. And that is the peptide stack for high blood pressure. So very straightforward. But again, when we think about high pressure, think insulin resistance and a lot of chronic disease is going to go back to that. And if we can manage and take control of our insulin sensitivity, we're going have a much easier time bringing down blood pressures. The reason blood is so important is because it's arguably one of the more direct causes of cardiovascular disease and heart disease,

19:39 which is obviously, obviously the number one killer of people in the first world today. So we take control of that. It's going to reduce this. I don't have the stats offhand, but it's, it is going massively, massively helpful in helping reduce any sort of risk we have for a cardiac event. So that is the peptide stack for high blood pressure. If you stuck around to the end, thank you guys so much. Uh, if you have questions, comments, concerns, anything like that, uh, about this video, definitely drop them down in the comments below. And, hopefully this was helpful. My goal, you know, with all of this is to have teaching material that it's useful and relevant to your life that you can take all of this and run wild

20:14 with it and improve your health. And then obviously too, if you like the material that I talk about, don't forget to check out our private membership, fully optimized health that have with Jay Campbell. We have almost, I think there's over 470 something people in there now, so almost 500 members signing $9 a month. You can cancel anytime, but that is the premier biohacking group in the world. Uh, we do weekly AMAs or any, um, and stuff. Then we also have a forum where you can ask questions. and get all your questions answered, especially around peptides, because they are all the rage right now. So much love out there. Appreciate you guys, and I will see you in the next one.

20:45 Peace.