The Peptide Stack for Liver Health

0:09 Hey everybody, this is Hunter Williams. I hope you're doing amazing wherever you might be in the world. Today, I have a pretty cool video. This is going to be the peptide stack for liver health. And you know, There's some peptides that you probably have heard of, but you don't realize in the context of liver health, how important they are too, because liver. Health is one of those things that affects way more people than you really realize.

0:41 Again, we always think about the four horsemen of death, you know, cancer, cardiovascular disease, and some of these other major issues that are out there. but liver health is massive. And so we're going to walk through that today. Some of these peptides, you probably would say, okay, that makes sense. It's for liver. Health, but other ones you may have not have heard of, or you made about have realized the profound impact that we have some data around in terms of what they do for live or health. So I'm excited for this one. it's going be really fun and enjoyable, I think, to go through and kind of see what mechanistically these guys are doing.

1:14 But then also some of the data behind them in term of how impactful they are for the livers. And I also think this is one of those things. Yes, there are people that suffer from severe liver disease. However, our libers are the biggest detox organs we have in the body. So whether or not you're someone that is obese and has liver or you are just someone who is trying to optimize and do your best and dial every single facet of your life in for optimal health span, liver health is something that is a really big cornerstone of that again, because they are the largest detoxifying

1:49 organ that we have in the body. And it's, it really how it is really important in terms of how our body functions living in environment that are all exposed to that. We really can't do too much about. So the healthier our liver is, the better we're going to detox things, regardless of not of whether we severe liver disease. Whether you're someone that's suffering from severe livers disease or even someone who's already really healthy, I think you could run the stack. preemptively to have a good effect on your liver health for the long term. As always before jumping the slides, make sure you are on the email list.

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2:53 So make sure you're on the email list. And without further ado, today we're going to talk about the peptide stack for liver health. All right, let's jump into it. Rejuvenating liver health. This is going to be a 12 week peptide protocol. Again, as with all of the different protocols that I make, I am sure there are many things, especially in the case of liver, health that could be added to this to improve liver. Health again, there's tons of different vitamins and supplements. I'm sure. There's. Tons of other different pharmaceutical drugs, but for me, this is gonna be. A combo of some pharmaceutical drug, then also some peptides.

3:24 These are the best peptides I think that we have access to right now, at least with relative ease and commercial viability that can get our hands on and use to make an intervention with liver health. So I'm really excited. Let's jump into this. Just to kind of frame the background on liver put forth these numbers for you to give you the scope of how big of an issue this is because again, it's one of those things that you start digging into and it is mind boggling how many people suffer from this and its not the typical thing you might hear at a dinner party or what not.

3:54 30% of the world's population is affected by NAFLD or MasLD, which is basically non-alcoholic fatty liver disease. This means that they have issues with their liver. They have liver diseases, not from drinking alcohol, where they would have cirrhosis of a liver from over consuming alcohol. Again, 30%, three out of 10 people are going to struggle with issues, with the liver, from metabolic dysfunction. 882 million people, almost 1 billion people worldwide, and that was in 2017. It's probably much worse now.

4:31 And specifically to the research that I did, there's not any FDA approved drugs specifically for NAFLD. I know there are some small molecules that i have heard rumblings of being out there that would get approved for this or they may be approved, but I shouldn't come across those. Again, I'm sticking to peptide stuff today. But again, non-alcoholic fatty liver disease has really become a silent epidemic. And again we are seeing this now. It's not just older people. We're seeing in children and adolescents. Now think how metabolically unfit or unhealthy a child that's 12 or 13 And unfortunately, it's not all the time their fault.

5:06 It's the environment they're born into and the food their parents feed them are suffering from this. But ultimately it leads to inflammation, fibrosis, cirrhosis, or even liver cancer in a lot of cases. And of course, most medical advice stops at diet and exercise, but we have a lotta peptides and that's what we're gonna talk about today on how we can use those. Of course, the first one is going to be retitrutide. Now, you probably are like, okay, here we go. Retitutide, another GLP peptide for another use case, right? Well, GLPs peptides, as it stands right now is at the time of this filming, to me are the best longevity medications that are out there pound for pound.

5:43 When you look at everything that they do in the body, if you could choose one longevity medication, it's going to be a GLP. But when we look at retitrutide specifically in the context of liver health, It's incredible. So let's look at some of the data. Obviously, we're at a true tide. It is the GLP-1, the GIP, and the glucagon agonist tri-agonist peptide. it probably will be FDA approved at point later in next year in 2026. That's going to act as a metabolic master switch. This is going curb appetite, enhance insulin release, an increase energy expenditure through those three mechanisms.

6:17 Now, when we look the evidence, what happens? Well, We have 24% body weight reduction in a 48 week phase two trial. There's lots of other trials going on. I'm sure there will be more data that comes out, but that's the best we have access to now. Now this is where it gets crazy around liver health, because when we look at the higher doses, which are going to be in the 8 to 12 milligram range within 24 weeks, there was 81 to 82% liver fat reduction. I want you to understand how powerful that is because again, when we're looking at this, most of these people are not changing their diet.

6:49 They're not doing anything else other than injecting the drug. And these People are losing 80% of their liver fat at the eight to 12 to milligram doses. Now, do you want to be on that high of a dose for all time? No, but I think it's pretty powerful and telling. And again, whatever the use case is, if it is to optimize your liver or to heal fatty liver disease, I don't know anything else out there that is really doing that at that level. Then we're going to compound it with some of these other peptides that we are going talk about today.

7:21 This is crazy too. For people with fatty liver disease, there was an 89 to 93% resolution rate of the disease. Meaning that they no longer were diagnosed with Fatty Liver Disease after using Rettitrutide for 48 weeks. I don't know how close you could get to 100% with any drug and healing any disease but that's about as good as it gets. And again, so Rrettitutide, fat loss, peptide. Yeah, whatever. Look at what it's doing to the liver. That is insane. Obviously we see improved blood sugar, cholesterol, and blood pressure, but even there was one doctor that I came across that was quoted in one of the studies,

7:55 read a true time, wiped out the fat in the majority of obese NAFLD patients, a dramatic result suggesting top tier therapeutic potential specifically for NAFLD or mash as it sometimes called. Now, why is it doing this? What is going on with retitrutide? First, I have as the foundation of the protocol, again, if you can only have one peptide out of this, that would say retritrutite for liver health, it's the cornerstone. It creates healing conditions by emptying liver fat stores and normalizing enzymes. And it also helps address the root cause of fatty liver disease, which a lot of times is metabolic dysfunction.

8:29 it addresses this metabolic disfunction and improves insulin sensitivity and it improves liver lipid profiles. And over eight to 12 weeks, we gradually will titrate to an effective weekly dose that I would say is somewhere in the eight milligrams per week. Now, before you lose your mind and say, Whoa, that's way too much. I'm always going to recommend people titrait up to that dose. And in some cases, you might have to do that much more than 12. It might be 48 weeks like it was in studies. But I would not go to eight milligrams right off the bat at all.

9:00 I will start with one to two milligrams per week. And then over the course of four to 8 weeks, depending on how well you tolerate retitrutide, I wouldn't work up to that eight milligram mark. Again, the eight-milligram mark is specifically for fatty liver disease, liver issues that people may be having. That is not the longevity dose. the, the optimization dose. That is not even what I would call the 10 to 15 pounds dose that is the fatty liver dose, hence if you have fatty, liver disease,

9:31 you're going to see that almost close to 100% resolution of the Fatty Liver Disease at those higher doses. And again, that's not for everyone. But specifically today, we're talking about in the context of fatty liver disease, it is doing more things at that level, which has to do with the glucagon activation being much, much higher at the eight milligrams dose. There's glucogon activation at every level. Four milligrams per week seems to be the threshold dose to which the glue could gone is really accelerating repair on the liver.

10:02 But 8 mg is where we see most of this. And again, these are diabetic obese people that have liver issues. The next one is going to be the SGLT2 inhibitors. Yes, I got the stock answers out of the way. So retitrutide plus an SglT 2 is magic. But let's look at what it does for the liver. It acts as a sugar valve in the kidneys, which causes excess glucose to spill into the urine. which then lowers blood sugar independently of insulin. And when we talk about that in the liver, obviously that is a huge benefit to the kidneys and kidney disease. But when you look at the lever, it reduces conversion of sugar to fat, forces the body to burn fat for energy, which, then,

10:38 lightens the lower metabolic workload. So basically, very similar to what it's doing with the kidney, the SGLT2 is taking this weight vest off of the level that it is basically making the live a plow horse metabolically for someone. It's taking that weight off of them, which is pretty cool. There was a meta-analysis that I found 10 randomized trials of 573 patients show that SGLT2 inhibitors significantly reduced ALT and AST, our liver enzymes, and decreased liver fat by 2.2% and also improved body composition.

11:10 Is it read a true tide in terms of eliminating the liver fat? Obviously not. It's not pulling as much fat off the lever. But what it's doing is it is taking this metabolic burden off of the body that's going to allow the live to breathe. Imagine if you had a huge anvil around your liver, just squashing it and like squeezing it. The SGLT2 is going to take that off and allow some of these other things we're going talk about to work even that much better by lightening the metabolic load. Basically the SglT 2 is gonna turn off the FOSA. It prevents new fat accumulation from excess glucose while other therapies drain the existing fat.

11:44 And also works as a metabolic safety net so it steadily lowers fasting glucose and insulin providing stable energy and supports weight loss. Also has a major anti-inflammatory effect on the whole body. It also shows signs of anti-fibrotic events, potentially showing slowing fibrosis progression. And again, it's just a daily pill. Again, you would want to use it in the context of this for at least 12 weeks, but I would say based on the data that I have right now, I plan on taking these every day for the rest of my life because they are that powerful for longevity. But when you talk about the liver, its even that much better.

12:14 The next one you probably would have guessed is glutathione. Glutathion is the liver's chief detoxifier and again it's a tripeptide that neutralizes harmful free radicals and reactive oxygen species from fat metabolism and inflammation. It also acts as a chemical sponge Soaking up toxins, binding heavy metals and protecting cell membranes, mitochondria and DNA from oxidative damage. Again, this is going to help with the liver's detoxification processes. When we speak of it specifically in terms of the Again, we have a high quality supplementation which I would say is 200 milligrams at least four to five

12:51 times a week in this case. It continuously bathes the liver in antioxidants which counteracts the oxidative stress from fat burning. And also cleans fat-burning so it ensures fat mobilization produces fewer toxic byproducts preventing damage to liver cells during rapid weight loss. Again I think it's one of those things I've seen people use GLPs and even GLP's at a pretty high dose and they still can't seem to get a lot of stubborn fat off and then for whatever reason, and I think it's this reason right here, introducing glutathione all of a sudden cleans up and allows them to keep

13:25 bursting through plateaus. And again, if the alternative is doing 16 milligrams a week of Retatrutide versus doing 8 milligrams per week and then introducing glutathione, we're going to get better results than even with double the dose. But I've seen this, especially in people that have a heavy toxic load, whether they're alcoholics or exposed to mold and they are trying to lose weight at the same time, glutothione makes a massive difference in their life. And for someone that doesn't have that, it might not be a big deal, but I'm just seeing it time and time again. We also have to realize too that the way that fat loss and fat oxidation is happening in the body, we're basically releasing these toxins from the fat

14:02 cells and the glutathione is helping clean that up, it's helping the liver get rid of some of those things. So again, its helping liver do what it needs to do as we are lightening the metabolic load on the livers. It also is going to support mitochondrial function, specifically the mitochondria in the liver, lower systemic inflammation and improve insulin sensitivity. And they, a lot of times too, this is where people report energy and mental clarity boost. Again, when we talk about Reta-Trutide, A ton of people get really tired on RETA-TRUTIDE. One, because they're at calorie deficit and they are burning more calories.

14:33 So by, by default, they going be more tired, but a of the times again, their dealing with Some of these toxins that are getting released from the fat stores in the bloodstream and the liver needs help clearing those out. So it's very important in process of losing weight that we have glutathione alongside some of the other peptides. It also works as the molecular cleanup crew, ensuring aggressive fat and fibrosis reduction occurs in a protected primed environment for healing, which is pretty cool. Again, I think glutathylens is one of those things. I use it every week anyway, but specifically for liver disease, yeah, you're going to need it.

15:08 MotC, everyone loves Mot-C. I love Mot C. It's an exercise mimetic. And we're going to talk about it specifically in the context of liver health. So mitochondrial spark plug, mitochondria-derived peptide that enhances cellular energy production, optimizes glucose use and activates antioxidant defenses. Also is going work on cellular signaling. so it interacts with BCL2 protein to prevent excessive cell death. It also activates the NRF2 pathway for antioxidant response. It basically triggers the same beneficial pathways as physical exercise, which revs metabolism, defends against stress, and enhances fat burning.

15:45 In my experience, in a lot of cases, for someone that is struggling to exercise is going to give them the energy to do exercise. Obviously, if they can't exercise for whatever reason, for instance, they're bedridden or whatever. Matzi is going to kind of induce those processes in the body to get them going. And if I would recommend again, if someone for whatever reason can't exercise, Matz does great to help alongside that at the right dose. But let's look at what it does for the liver. There was a 2024 cell report study around Matzie and it dramatically alleviated liver disease in mice, they had less fat accumulation,

16:22 lower cell death and reduced inflammation and fibrosis. Another 2025 scientific reports study looked at MOTC as an effective as aerobic exercise and improving liver fibroces through NRF2 activation and TGF beta suppression, which is pretty cool. Again, we look at motc, is it doing directly the same thing that breadotrutide or maybe even Glutathione is doing no, but through some alternative pathways, it is lightening the load on the liver, leading to less fat accumulation and reducing inflammation.

16:55 It's going to burn fat. it's gonna prevent steatosis through endurance, excuse me, through enhanced oxidation. It's going to block injury through antioxidant and anti-apoptotic effects. And it's also going stop fibrosis. Again, we're kind of stopping some of these processes that are going on or progressing in someone with fatty liver disease with a peptide like MOTC. So it is going tame inflammation and stellate cell activation. At my dosing, I like one milligram a day subcutaneous injection. It simulates exercise at the cellular level. It increases the liver's fat burning capacity, up regulates antioxidant responses and prevents fibrosis by cutting multiple injury drivers.

17:33 Just as a disclaimer, there's this myth that will not seem to die that you need to take five to 10 milligrams of Matzi two to three times per week because after you mix it, it becomes less stable. There's actually a published paper on this, and they showed that that is not the case. I've used Matzi tons of times. Mix it like any other peptide, put it in the refrigerator, use one milligram per day. Honestly, if I do a higher dose than that, I kind of will go hypoglycemic because it's so powerful. And some people when they do five to 10 milligrams, they actually go into anaphylactic shock.

18:06 I would highly recommend you do not start off doing five to ten milligrams of Matzi. Usually one milligram per day is good enough and the cumulative effects you're going to get over time are very powerful. So don't jump to those high doses one because it could be kind of dangerous where you could go into shock. but also two, you're going to get a cumulative effect. And so when you were doing it one milligram a day, if you are doing every day you really get seven milligrams a week or even five milligrams week if your doing Monday through Friday and you getting close to that total dose but you just breaking it up and spreading out the benefits over time.

18:40 SS31, yes, another mitochondria peptide. Yes, you can use Motzi and SS 31 together. I don't always recommend that. However, if someone came to me and was like, hey, I've got fatty liver disease. yes I'm going to put these two together, the rule of thumb is always, Hey, SS-31 is going make the Motze work better. So use that before you go to Motzie, but you definitely can't use them together again. There's no, there's not necessarily right or wrong or rhyme or reason to it. They're both great peptides. We look at SS31, it's a synthetic peptide that homes in on the mitochondria embeds in the inner membrane to stabilize the electron transport chain.

19:14 It also neutralizes reactive oxygen species at the source in a lever preventing damage to mitochondrial DNA and membranes. And it also restores energy, it helps the liver produce energy efficiently with less oxidative leakage, supporting cellular regeneration. It's basically like installing a high-tech filter in an engine to prevent wear and tear. SS31 restors the mitochondrial function in fat-loaded liver cells and reduces inflammation by modulating immune signaling. Works really, really well alongside Reta-TrueTide as does MOTC.

19:44 But let's look at it in the context of liver. When we look mitochondrial pair of the liver, it reduces H2O2 production, increases ATP and preserves healthy structure in diabetic fatty liver models. Also acts as an anti-inflammatory around the lever. It increases autophagy and reduced cytokine release and human liver cells exposed to inflammatory stimuli. And also when we looked at tissue protection, if preserved liver mitochondria and prevented immune cell activation in acute liver injury models, And for the SS-31, I would actually recommend that you take up the dose higher.

20:15 You could do a one milligram dose with Matzi. But in the case of liver, i like the five milligram dos. And again, that probably becomes cost prohibitive for some people. When we get a five-milligram dose of SS 31, it's going to be really powerful at doing some of those things we just mentioned. Again, this provides the longevity effect. It makes metabolically stressed livers act more youthful and resilient in over 12 weeks. Reduces ongoing damage, lowers oxidative stress biomarkers and creates a supportive environment for sustained healing. Again it does work in this instance synergistically with MATC.

20:46 MAT C basically revs up the mitochondrial engine while SS31 protects and repairs it. I always make the analogy SS 31 is the hardware repair for the liver or in the case of liver for a lot of things, but to the Mitochondria in general, and then SS31 is the hardware, Mozi is software, and they work great together. Again, you can rotate them. In the case of a liver stack, I would add them together The next one, this is the one you probably haven't heard of, is called Ovagen. And Ovogen is a liver bioregulator peptide, meaning that it is peptides specifically designed to work on liver tissue, specifically,

21:22 which is pretty cool. It is tripeptide derived from liver tissues that signals liver cells to normalize function and activate regeneration programs. It modulates DNA and histone proteins, promotes gene expression for tissue repair and healthy cell metabolism. And when we look at the actions, it ends up reducing oxidative stress markers, decreasing collagen deposition in the liver, encouraging hepatocyte protein synthesis and signals stellate cells to reduce scarring. Again, when you talk about these bi-regular peptides, think of them as a little messenger that when take it, inject it.

21:53 It is going specifically to liver tissue, so it's finding liver tissues, and it is then going into the DNA inside the nucleus of the cell, and saying, hey, this DNA is not sending off the right signal, let's go repair this. Let's put some building blocks in here to re-signal the DNA to a more youthful, less inflamed state, which is pretty cool, and ovagen is the one for the liver. When we look at what it's doing, it works, one, to normalize enzymes. There is data that it significantly reduces liver damage markers in toxin-exposed rats.

22:23 which is pretty cool. It decreases fibrosis by decreasing collagen content and chronic liver fibrocyst models. Also reduces scarring, also helps with tissue healing. it improves liver architecture with less necrosis and inflammation. I recommend again, the dosing for these is there's not like a lot of set dosings. What I've seen is a two milligrams daily continuously nudges the liver towards regeneration acting as a coach. to recover, rebuild, and don't overscar. Again, when we use this over 12 weeks, we definitely are going to see some normalization of those markers like ALT.

22:56 The next one is going liveagen, another bioregulator peptide. It works on epigenetic renewal. On chromatin decondensation, it opens tightly packed DNA to reactivate silenced beneficial genes that have been turned off through whatever it is that caused the liver disease in the first place. It also restores youthful gene expression patterns in liver cells, helps with the immune system inside of liver cell controlling chronic inflammation, also stimulates production of protective enzymes that work as antioxidants, and then it normalizes the rhythm in cells of aged organisms against a tetrapeptide

23:33 that works at the DNA level to improve cellular function, reminding cells how to behave when healthy fostering. anti-inflammatory and regenerative conditions. And again, think of these as messengers that are coming in and you know, it's the liver's hanging on for life and it kind of like smacks it in the face and says, hey, like wake up, we need to change, We gotta go, and that's what these two bioregulator peptides are doing. When we look at it, in context of disease, there is high efficacy in liver fibrosis and hepatitis models that it normalized immune and antioxidant status,

24:05 restoring liver function and mitigating fibrotic changes. Also, it's going to normalize ALT and AST, which are those liver enzymes. It's gonna lower biluberin. I always mispronounce that. And also, its going help normalise cholesterol, Which enhances tissue repair with more glycogen rich hepatocytes. Also we're gonna see systemic benefits. So its gonna improve glucose tolerance, cholesterol regulation, and digestive enzyme profiles. Which lead to healthier liver outcomes. Again, the dosage for this is gonna be the same as Ovagen. Its gonna 2 mg per day.

24:35 over that 12 weeks to ensure a fully functioning liver is restored. And again, are Ovagen and Livagen going to make all the difference in the world if you just use them in isolation? Probably not. But what it's doing is coming in, we really want to hit that DNA signaling pathway specifically in liver tissue, and that's where it really shines. And again, when we talk about these, there's seven different agents, we kind of work across all these different things. So we have liver fat elimination, a metabolic reset, oxidative stress defense, inflammation control, fibrosis reversal, and regeneration.

25:09 And when you look at a multimodal approach, to liver health, these seven, and I know I usually like to stick to five, but I really wanted to throw the Ovagen and Livagen in there. These seven have concrete data to back them up, But also they're going to approach the liver from an entire multimodal standpoint, which is pretty cool and pretty awesome. And then there's the chart page. I don't need to read through all of that, but if you do want to screenshot it, if your watching the video, I've got all the dosing on there for these.

25:42 And again, that one that's different from probably what you'd see on the cheat sheet or whatever is the Retatrutide. Again, because I put on their, the eight milligram weekly doses where you really see that uptick and almost like the near perfect elimination of fatty liver disease over 48 weeks. But, There's a chart if you do want to screenshot it. And then just what to expect by week 12. Hopefully we're going to see significant weight loss if needed, drastically reduced liver fat. We're gonna normalize liver enzymes. we are going improve fibrosis, we gonna see better stamina, mood and sleep quality, hopefully.

26:14 and then we going see enhance mental clarity and energy. Again, 12 weeks is kind of what I'd say. Start this and see where you go and reevaluate. You may need to continue running these things. I think with the SGLT2 and glutathione, that's At all times, no questions asked. The Retatruetide, you may need to run that for even a year or two, depending on how severe it is. And then the SS31, the Matzi, and the Livigen and Ovigen, we can really more be a little bit more strict about cycling those just because we're going to maintain sensitivity over time. But again, when we look at it, we're cleaning up the liver structurally, cellularly and functionally, which is great.

26:49 And again when talk about liver health, whether it's for someone with fatty liver disease or someone that is just looking to optimize health span, do our body a lot of good by protecting and ensuring that the liver is in a healthy state. And that is it for the slides. That is the peptide stack for liver health. Hopefully that was clear and concise enough that you could walk away after listening to this video and say, hey, I've got an action plan to move forward and heal fatty liver disease. But as one of those ones, think about it, three out of 10 people in the world suffer from it.

27:20 Most likely you have some family member or some friend that are suffering from that. And if that's the case, I would just hope that you would enlighten them, maybe send them this video or just educate them that there are options out there more so than they would probably get from their normal doctor. But again, these are not a cure-all. There is no guarantee, even though the red trutide data is very, very strong, diet and lifestyle are important. Taking care of yourself is important, continuing to exercise is, important continuing, to move your lifestyle in the right direction is. And what's awesome now is we have all of these agents that are relatively easy to find, depending on where you live, that you can source and really improve

27:57 liver health, which ends up improving all of our health. And again, just as a takeaway, this is not just for people with fatty liver disease. I think it's something that all us would benefit from at different times throughout the year. Even if you didn't do the whole stack, I'd think you could cycle some of these in and still get good anti-aging benefit, especially for the liver, even with some bioregular peptides we talked about. And in closing, I just want to say thank you guys so much. It is a dream come true, a privilege, and an honor to get to do what I do. So whatever way you support this, if it's just listening, liking, commenting, subscribing, sharing it with your friends and family,

28:30 reading the emails, being on the email list, using my code of places, that makes a world of difference. And it allows me and enables me to bring these messages and this content to you. Again, i can't stress how thankful I am for you, guys. I know it probably gets old if you listen to me, for me saying that, but I always just want to close out with that because it really matters to me. And I want people that are out there that listen to this, wherever you are, to know that it, it means the world to have your support and be able to bring this to you. I don't take that lightly. Take it very seriously. Cause my goal and my mission is to, bring the best content in the word around these topics to guys.

29:04 That's it for this one. Thank you guys so much. Wherever you're at in world, have an amazing day.