Glutathione in 2025: Updated Benefits, Dosing, and My Protocol
Glutathione is one of those things I use every single week, but I don't talk about enough. The longer I use it, the more convinced I am that every researcher and peptide user should have it in their cabinet. This is my 2025 update on why injectable glutathione belongs in your protocol.
What Glutathione Actually Is
Glutathione (GSH) is often called the body's master antioxidant. It's a small tripeptide made from three amino acids. Glutamate, cysteine, and glycine.
It exists in a reduced active form that neutralizes free radicals. Then it gets oxidized and recycled back to active glutathione inside the cell. It plays a critical role in cellular redox balance and protecting mitochondria from oxidative damage.
You'll find it in particularly high concentrations in the liver, kidneys, and lungs. That tells you everything about its role in detoxification.
Our endogenous levels decline as we age, just like a lot of other compounds in the body.
Why Injectable, Not Oral
Oral glutathione gets broken down by digestive enzymes. Studies show that a 3,000 mg oral dose did not raise blood glutathione levels at all.
Some companies are working on liposomal versions and other delivery methods. To my knowledge, no one has fully cracked that code yet. Injectable is still the default if you want real efficacy.
NAC (N-acetylcysteine) is a precursor to glutathione production in the body. I recommend it for people who fear injections. But if you want the real good stuff, you're going to have to inject.
Injectable glutathione bypasses the digestive tract entirely. For at-home research, intramuscular is what I'm talking about. If you want IV, go to a clinic or use a delivery service.
Why It Matters More in 2025
Two things have made glutathione more important than ever.
First, the increased use of mitochondrial peptides like SLU-PP-332 can increase reactive oxygen species. We need an antioxidant to counteract that.
Second, we are exposed to more contaminants and environmental stressors than any generation before us. Phthalates, EDCs, glyphosate, you name it. Glutathione is extremely powerful in helping the body detoxify these compounds.
How It Works
Antioxidant defense. It directly scavenges reactive oxygen species and free radicals. It also serves as a cofactor for other antioxidant enzymes like glutathione peroxidase.
Detoxification. It conjugates with toxins and heavy metals via transferase enzymes, making them water-soluble for excretion. This supports the liver and kidneys in clearing drugs, pollutants, and metabolic waste.
Immune support. It promotes T lymphocyte proliferation, enhances natural killer cell activity, and optimizes antigen-presenting cell function.
Cellular function. It helps regenerate vitamin C and E, maintains mitochondrial function, and regulates cell death pathways. A lot of people notice an unexpected energy boost.
Clinical Benefits Worth Knowing
Liver disease. In non-alcoholic fatty liver (now often called MASH), glutathione therapy significantly reduced ALT, AST, triglycerides, and ferritin. In chronic hepatitis B patients, IV glutathione added to antiviral treatment improved liver function and viral clearance.
Male fertility. A study using 600 mg every other day for two months significantly improved sperm motility and morphology in men with varicocele-related infertility. That's a high dose. I think you can get the same effect with a lower dose. Given the decline in fertility rates from chemical pollutants destroying endocrine health, this matters.
Chemotherapy support. IV glutathione alongside cisplatin reduces kidney damage and neuropathy without reducing anti-cancer efficacy. Meta-analyses show lower risk of severe neurotoxicity.
Parkinson's. Patients have reduced glutathione in the substantia nigra. A small open-label study using 1,400 mg IV three times weekly for four weeks showed mild symptom improvements. Benefits faded within 36 hours, which suggests intramuscular dosing might give a steadier effect.
Cardiovascular. In peripheral artery disease, IV glutathione improved pain-free walking distance. In coronary artery disease, IV glutathione protected against contrast-induced oxidative stress better than oral NAC.
Skin Health
Glutathione has anti-melanogenic properties. It inhibits tyrosinase and shifts melanin production toward lighter pigments. This is the opposite mechanism of Melanotan.
Some Asian markets use it specifically for skin lightening. Studies show conflicting results, with mild and temporary pigment reduction. Health agencies generally advise against using it for that purpose.
Personally, I wouldn't push high doses for skin lightening. If it does lighten skin, your defenses against sun exposure could be weakened. I prefer Melanotan because it protects me from burning. I never used sunscreen at the beach this summer with 300 mcg of Melanotan daily and didn't burn once.
Two randomized trials did show modest lightening plus improved skin elasticity and reduced wrinkles. There is some skin benefit. One quirk I've noticed personally, glutathione gives me a few white or gray hairs in my beard. If that bothers you, GHK-Cu helps with hair color. Don't mix them in the same syringe though.
A Real-World Example
My brother-in-law was a heavy drinker. Not quite alcoholic, but pretty prolific. I got him on peptides and hormones and saw leaps and bounds progress.
His triglycerides and liver enzymes were high. Glutathione really helped his body detoxify and clear up fat on the liver. GLP-1 helped too. But it made a huge difference in his life. That's when I realized how powerful glutathione can be for someone whose body needs help detoxing decades of damage.
Dosing
Here's how I think about it.
General wellness. 100 to 200 mg, one to two times per week.
Skin brightening. 900 to 1,000 mg per shot. I don't advise this.
Chemotherapy support. Around 600 mg every day or every other day.
Male infertility. 200 mg three to four times per week.
Liver disease. Around 300 mg, three to four times per week.
For most people, 100 to 200 mg once or twice weekly intramuscularly is the sweet spot. Not cumbersome, low post-injection pain, real benefits.
Practical Tips
I use a 28-gauge half-inch needle for intramuscular. Same one I use for testosterone. A 29 gauge can work but anything smaller doesn't deliver well because glutathione is a larger, more viscous molecule.
If you can find bacteriostatic water with taurine added, it reduces the post-injection pain and helps with absorption.
Side effects are usually mild. Post-injection pain is the most common. Some people get redness, swelling, or occasional flushing on IV push. Serious adverse events are rare.
Why You Should Replace It Like a Hormone
Dr. Elizabeth Yurth talks about this a lot. We replace hormones as they decline with age. Why aren't we replacing peptides like glutathione, MOTS-c, SS-31, and GHK the same way?
These compounds decline as we age. We're exposed to more oxidative stress. That leads to chronic disease, which lowers them further. Supplementing makes sense.
My Take
Glutathione is a staple. I use it once or twice a week pretty much every week of the year. It pairs nicely with everything else most of us are already doing.
It's not flashy like a GLP-1 where you feel something obvious. It's one of those things you know is doing real work after repeated use, especially when you see your liver enzymes and inflammatory markers improve on bloodwork.
If you have Lyme, autoimmune issues, metabolic dysfunction, or you've drunk heavily for years, glutathione probably moves the needle more than you think. We get caught up chasing the latest peptide and forget the foundational ones. This is one of them.
Full transcript click any paragraph to jump video
Hey everybody, this is Hunter Williams. I hope you're doing amazing wherever you might be in the world. Today's video is going to be my 2025 update on glutathione or more appropriately called L-glutathion. Most people just call it glutothione, easier to say. You know, glutathione continues to be something that the longer I've used it, which I'd been using it for years now, but the long I use it the more and more I am just convinced that it should be.
Something that every single researcher slash peptide user has in their cabinet and pantry. And today I just don't want to do an update video to some of the videos I have already made in the past. I think I made two videos in past about glutothione. But today I want to do an update video to glutathione and just add in some some newer evidence, I guess, clinical evidence to look at the benefits of it. But then also to just to give my informed update and recommendations on it, especially in light of Two things.
One, the increased use of mitochondrial peptides or mitochondria agents, particularly SLU-PP-332, which if used too much can increase reactive oxygen species within the body, to which we need an antioxidant to counteract that if we want to cover our bases. And second, to the amount of contaminants and environmental stressors that we are being exposed to on a daily basis. And that number is only going up, it's not going down. Glutathione, when we look at liver function and a host of other functions of the body, is extremely powerful in helping assist the bodies in cleansing
and detoxifying some of these compounds that were exposed on daily bases. Thalates, thalites, EDCs, glyphosate, you name it. I think glutathione, or I know glutothione is something that everyone should be using on a regular basis, if not one to two times per week, at least for six months out of the year where we're cycling on and cycling off of it, kind of depending on your need. So that's what today's video is going to be about. Hopefully it is educational and informative at the same time.
Thank you guys so much. As always, don't forget, all the links are down in the description. This will be on Spotify at time of this filming. But thank you, guys, so I truly have the best audience in world. And without further ado, I'm going share my screen and today we are going talk about glutathione. All right. I am Hunter Williams and today we're going to be learning all about injectable glutathione. So just as a brief overview, what is glutothione? So the abbreviation, if you ever see this written on anything that you're reading is GSH and it's often called the body's master antioxidant and we can actually supplement it, supplement with it exogenously.
It is a small protein, otherwise known as a tripeptide made from three amino acids, which are glutamate, cysteine, and glycine. And it also exists in a reduced active form that neutralizes free radicals converting to an oxidized form which is then recycled back to active glutathione in the cells. It plays a critical role in maintaining cellular redox balance and protecting mitochondria from oxidative damage. Like I talked about the intro. It's also found in particularly high concentrations in the liver, kidneys and lungs, which reflects it's important in a detoxification process.
Obviously those three organs are the most important organs as it relates to detoxifying. So it's three amino acids. Those are the building blocks of glutathione and our endogenous levels obviously tend to decline as we age among other chemicals in the body. Now let's look at this bioavailability challenge because it would be really, really nice if glutothione came in an oral form that was easily digested and used. Unfortunately, it doesn't. Oral glutathione is broken down by digestive enzymes and studies show that a 3000 milligram oral dose did not raise blood glutethion levels at all.
Now I know in this time that there are companies that are working on liposomal, glutothione and these other delivery mechanisms that not injectable. I don't know if there's anyone out there that's cracked that code yet. At the time of this video, to my knowledge, there isn't. Thus, injectable glutathione becomes the default thing if we are really wanting to get the full efficacy out of our glutothione use. Now there is inacetylcysteine, which is a precursor to glutethione. I do recommend taking that for people.
especially if you fear injections and acetylcysteine, otherwise known as NAC, is great. I highly recommend that to people because it acts as a precursor to glutathione production in the body. However, if we want the real good stuff, we're going to have to inject. Injectable glutothione bypasses the digestive tract entirely. It delivers directly in your bloodstream for immediate bioavailability. And because oral glutethione is largely broken down in a gut and not efficiently absorbed, injectable, which is going be done IV or IM for the purposes of this video, obviously for at home research.
Let's say IM is going to be what I'm talking about. If you wanted IV, I would recommend going into a clinic or having a Clinic Delivery Service come to you. I know those are getting popular now, but these delivery mechanisms have become much more popular in recent years. And like I said, glutathione levels tend to decline with age and chronic disease. which contributes to increased oxidative stress and impaired immunity in older adults. And we're going to see today that the benefits of glutathione are multifaceted. I just know from my own practice is one of those things What's the best way to say this?
It's one of those things that it's harder to put your finger on, but you know it to doing something. And so it is hard for me, just let's contrast this with a GOP1. GO1 you take it, your appetite suppresses, you get appetite suppression, and you lose weight. It is very apparent what's going on. Whereas glutathione, You don't get a high from it. You do not get like a buzz from or anything like that. But you after repeated use that is doing pretty impactful for the body. That being said, let's look at these mechanisms of action of glutathione. We have antioxidant defense. Glutathion directly scavenges reactive oxygen species, which those are those ROSs I was talking about, and free radicals which protect cells from oxidative damage.
It also serves as a co-factor for other antioxidate enzymes like glutothione peroxidase. Detoxification, like we mentioned, it conjugates with toxins and heavy metals via glutathione as transferase enzymes, making them water soluble for excretion. And it supports liver and kidney, the kidneys in neutralizing drugs, pollutants and metabolic waste. So you see we have its ability to help make some of these toxins water-soluble to get out of the body. It also supports the immune system.
it promotes T lymphocyte proliferation. And enhances natural killer cell activity and optimizes antigen presenting cell function, which bolsters both innate immunity and adaptive immunity as the bodies introduced to stressors that might not know how to defend. We also have an improvement in cellular function. It helps regenerate vitamin C and E, maintaining mitochondrial function and regulates cell death pathways which is essential for energy production. A lot of people notice an increase in energy when they are using glutathione which they don't expect but it happens.
When we look at injectable delivery methods, we have IV. What IV is known for is a rapid short-lived increase in plasma glutathione levels. The levels peak within minutes and it has a short half-life in the blood and is cleared within minute. Typical doses are going to be 1000 to 2000 milligrams. Conversely, We have intramuscular, which I am a fan of, at least if we're talking about to able to do once or twice a week on a regular basis with relative convenience. With intramuscular, there's a gradual absorption into circulation.
There is a more prolonged raise or rise in levels, but it has a lower peak concentration, which makes sense. It's absorbed over hours from muscle tissue and typical doses are going to be 100 milligrams to 60 milligrams. You could even start with 50 milligrams if you wanted to. I like somewhere in the middle, depending on what we're using it for. And when administered by injection glutathione enters the bloodstream directly, which is why we like injection, and it's quickly oxidized or broken down in domino acids which cells can then use to resynthesize glutothione intracellularly within the cell.
Both routes bypass digestive degradation which results in higher bioavailability of the active compound. Let's look at some of the clinical proven benefits, so we know this for a fact based on clinical evidence and studies. Looking at liver disease in non-alcoholic fatty liver diseases, which is increasingly become called MASH. So you ever see NAFLD, non alcoholic fatty-liver disease. We also have MOSH, I think stands for metabolic something steatosis or steototic hepatitis, basically fatty livers disease,
Glutathione therapy significantly reduced liver enzyme levels, which you will see as ALT or AST on your blood work, like triglycerides and ferritin. Also in chronic hepatitis B patients, adding IV glutathion to antiviral treatment led to greater improvements in liver function and higher viral clearance rates. A lot of times, people forget how great glutathione is for immune function. We tend to look at the immune peptides, which are great, dimethylamine alpha-1, thymalin, LL-37, but glutothione should be paired a lot times in a lotta
cases with those. This is something that I have actually looked at in the past, never really talked about publicly. A lot of people in bodybuilding community talk about this when we look at male fertility or male infertility. Intramuscular glutathione, which they did a higher dose than I would start with. In this case, they had 600 milligrams every other day for two months. That's a high dose. I think you get the same effect with a little bit lower dose if you wanted to. But if your really going for fertility purposes, I'm going to be talking about very soon. Stay tuned for that between me and Taylor.
But they did 600 milligrams every other day for two months and it significantly improved sperm motility and morphology in men with varicocele related infertility or general tract inflammation, which is pretty cool. And I think when we look at sperm activity and sperm utility, one of the reasons we have this massive decline Infertility rates in the U S is like I said, these chemical pollutants and toxins that are destroying the endocrine health of humans right now. And if we give the body an ability or something that gives the bodies it's an a ability to have a chance to fight off some of these things,
which we weren't exposed to in prior generations is going to help improve the sperm health amongst other things. It's also too used as chemotherapy support, not a lot of people realize IV glutathione alongside cisplatin chemotherapy reduces kidney damage and neuropathy without reducing anti-cancer efficacy of the chemotherapy. It's proven in some countries as an adjunct therapy to chemotherapy with meta-analysis showing lower risk of severe neurotoxicity from the chemo therapy. I don't know what your thoughts are on chemotherapy. I'll reserve mine for the purpose of this video.
But if you're going to go that route, it could be beneficial. There's also some pretty cool neurological applications. When we look at Parkinson's disease, patients with Parkinson have reduced glutathione levels in the substantia negra region of the brain. And one small open label study, IV glutothione at 1400 milligrams three times weekly for four weeks was associated with mild improvements and symptoms of Parkinson. Patients also reported better function for about 24 hours post-infusion, though symptoms reverted within 36 hours, which showed that it was a little bit
more of a transient benefit. Now, this is where we would see actually a most likely better use case for intramuscular because we're not peaking and troughing within hours as we went with IV. We're seeing a more steady rise and we could do daily or every other day injections to hopefully extend that benefit and especially in something like Parkinson's disease. Also, a placebo-controlled trial of intranasal glutathione found no significant difference from placebo, suggesting more research is needed to establish efficacy. People will talk about intrasal. I think intransal is better than nothing.
Maybe we see more of a neurological benefit with intrnasal versus the injectable. However, stands the reason that I would support injectible over intanasal, although I you got to get it how you can, if it's not something that you're going to be willing to do intramasals better that nothing, This is pretty interesting when we look at heart health. Obviously, heart disease is still the number one killer of people worldwide. When we looked at cardiovascular and vascular endothelial health in small trial patients with peripheral arterial disease,
IV glutathione therapy improved pain-free walking distance, suggesting a better blood flow or reduced oxidative damage in the vessels. In coronary artery disease, IV glutathione prior to coronal imaging protected against contrast-induced oxidative stress more effectively than oral inacetylcysteine, otherwise known as NAC, which I mentioned before. And these findings suggest glutothione can help mitigate oxidant stress in cardiovascular contexts. So when we look at heart health, they had improved walking distance and reduced oxidate stress. I think it stands to reason that anyone that is dealing with heart disease could benefit from glutathione.
Is it going to be as powerful as something like retitrutide or as powerfully as an SGLT2 inhibitor such as Jardience? No, but I would definitely use it alongside those things to improve heart health if that was something I was struggling with. Let's look at it for skin health. Now, glutathione, I have noticed, just to give you a quick personal note, it does tend to lighten my skin slightly. I would say a slightly more olive or tan complexion normally throughout the year.
Not pale, but I'm also not super tan.I love using Melanitan because it helps protect me from the sun. i don't have to use sunscreen when I use Melantitan, which is really nice. Even this summer when we were at the beach I'd never use sunscreen once because I injected a tiny dose around 300 micrograms of melanotam every day and that kept me from getting sunburn being out of the Beach at The Sun all day. Now when you look at glutathione there are certain ethnic subsets particularly Asian subcultures that like to lighten the skin so they actually don't want
to get tanned. If you're from America, this is probably a lot of times counterintuitive because you would think, why would someone want to lighten their skin when it comes to aesthetics? At least as far as I have been raised in the world, most people want it to be tan instead of lightening their People will attempt to use glutathione to lighten their skin, and there is some evidence, although it is not definitive. When we look at skin health and glutathiolm, glutothione is great for skin. I will say that. And we looked at the mechanism. It has anti-melanogenic properties.
it inhibits the enzyme tyrosinase and shifts melanin production towards lighter pigments. through a different mechanism, but kind of opposite of what Melanotam would do, which underlies its controversial use as a skin lightening agent. There have not been any large trials that have been published for IV glutathione and skin whitening. Small studies show conflicting results with any pigment reduction appearing mild and temporary, and the effects fade after stopping treatment. Health agencies typically advise against using injectable glutethion for skin lightning, specifically due to unapproved safety reasons.
Now, I don't think you're gonna have any safety issues with glutothione, we'll talk a little bit of that later. And theoretical concerns include inducing long-term skin cancer risk, which again, I don't think is a thing. But if we are just thinking about it rationally, if it does lighten the skin, If you are exposed to a lot of sunlight, your body's defenses against the sunlight, if there is overexposure would be weekend. Thus you would maybe be predisposed to getting a little bit more skin cancer.
Now, what I am not saying is a glutathione puts you at risk for skin. What I'm saying, is that we stand to benefit from being able to regulate melanin production in interacting with sunlight to which I think a peptide like melanotan one works great because it keeps us from having Oxidative stress response to sunlight like I was saying I wasn't the beach in the summertime. I'm being at the summer time when I use my lantern I don't burn. This is my opinion that's not medical advice or medical research.
I think that more people get exposed to it or more. People acquire skin cancer because they are responding to the sun in a way that they burn. Thus, when the body burns, we have the stress response and then that causes inflammation, which then can lead to cancer. However, if we keep the. Body in the state where it's not burning from the son and we are protected by the melanin in our skin, the theory would lead us to believe that we would be at less risk for cancer, Interestingly, there were two randomized trials that reported Glutathione not only had modest lightening effects,
but also improved skin elasticity and reduced wrinkles in some subjects. So I think there is a skin benefit for that. However, the highest level of evidence concludes Gluathionone is not beneficial enough as a skincare whitener, even though people use it off label for the purpose. I would say for me personally, I wouldn't say it necessarily lightens my skin, but a lot of times during the summer I'm using Melanotan. I will say though, it will give me little white or gray hairs in my beard. I guess if you're really trying to avoid any sort of graying or whitening of hair, overuse of glutathione is probably going to have some effect on that.
Now, I don't mind that, and like I said, it's transient. And then if really want to cover your bases, you could use GHK-CU because GH KCU will make your hair darker. So don' t mix them in the same syringe, but if wanted to use ghk and glutothione, Ironically, those are probably two of the most painful peptides to inject, unfortunately. However, if you're worried about that, you can use GHKCU to help with the hair and then if Now let's go back to some of the health benefits.
Like we said, we have enhanced energy and vitality by protecting mitochondria from oxidative damage. Glutathione supports better energy production. Many report improved energy, and less fatigue when antioxidant capacity is optimized. It's crucial for detoxifying drugs, alcohol, environmental toxins. Again, I'm not a drinker. If you're a drinking, glutathion would be something absolutely that I would have on hand at all times. And what I would do is use it the next day. If you are drinking at least 50 to 100 milligrams, but Hey, you got to live your life.
Adequate glutathione levels support liver function and prevent accumulation of harmful compounds, which contribute to clearer skin and improve metabolism. It also results in stronger immunity. Like we talked about, immune cells rely on glutothione for optimal function. Raising glutethione can enhance natural killer cell activity and T cell response, Which translates into better immune surveillance and lower susceptibility to infections. I wanted to make a little timeline of the body when we talk about Glutathione levels and then cellular protection. In our youth, we have high glutathion levels, and optimal cellular function.
We're all chasing the fountain of youth right? And because oxidative stress and toxin accumulation are drivers of aging, glutothione is often used for longevity and anti-aging benefits. Fast forward, we have middle age. We have declining glutathione levels and increased oxidative stress because we more years of exposure to the toxins and the stress of life. In older age, We obviously have lower glutothione, which is linked to age related diseases. So over time we. Have lower good with our levels. we get exposed to more oxidant stress. This leads to chronic disease, Which then even lowers good without levels that much more, is why we should supplement.
Dr. Elizabeth Yearth is one of the foremost peptide doctors in the country. I was actually recently on a panel with her in Las Vegas at the Mr. Olympia Expo. And she talked about how common it is for us to replace hormones. Well, common in our community. It's not common to the world. But when we look at some of these peptides like glutathione, why are we not replacing them the same way that we replace our hormones? And it's a very, very I think when we look at our world today, we'd look a glutathione levels. We look yet endogenous MOTC.
we looked at endogeneous SS 31 production. Look at some of these endogynous peptides. They decline as we age. Endogenous GHK is another example. Why would we not replace those in the same way that we replace hormones? And I that's where glutothione has as much a place as any, as some these peptide that were using. Studies have noted anti-aging effects in skin, such as better elasticity and reduced wrinkles with glutethione supplementation. Thus, while glutathione is no magic youth elixir, maintaining high glutatine levels is correlated with healthier aging and may protect against conditions
such as Alzheimer's, Parkinson's and cataracts. To sum up the clinical use cases, we have oncology support alongside chemotherapy. We have liver conditions, such non-alcoholic fatty liver hepatitis B. alcoholic liver disease. I think that's another thing that I haven't really driven home through this presentation. If someone is drinking and someone's drinking prolifically, I would at least use glutathione to help bring down their liver enzymes, just as a quick aside, not to bore you guys to death. But my brother-in-law was, i would say not an alcoholic, but a pretty heavy user of alcohol.
And I got him on peptides, got them on hormones and everything, leaps and bounds progress in his health like glutathione. And my guess to that was when I looked at his triglycerides and I look at. His liver enzymes, they were pretty high because he was a drinker and glutothione really helped allow his body to detoxify, clear up some of that fat on the liver. Obviously GLP has helped with that too. but it really made a big difference in his life and it was one of those things until that time I hadn't really realized how powerful glutathione could
be outsized and above some of these other peptides that are powerful but you look at someone that's abused alcohol for 40 or 50 years You know, the body needs help detoxing some of that. We look at fertility treatment like we talked about, oxidative stress and reproductive tract, impair sperm function, intramuscular glutathione improves sperm motility and morphology. You have immune support, so it can be used in chronic infections like Lyme, HIV, long COVID to strengthen immune defense. And then we just have wellness and anti-aging for people that want to cover all their bases.
It's popular in longevity clinics for detox and vitality boost. And for me, I think too, when we look at all those things, When the body gets exposed to more stress, will always up a glutathione. When I travel, but I'm in times of intense work stress or anything like that, glutothione is an absolute must. To circle back around to the injection over oral supplementation, like we talked about, oral glutathione is broken down by the stomach and intestinal enzymes. And when we look at it, it does not really, at least thus far, raise glutothione levels so far.
Poor absorption, which leads to kind of just wasting your money. versus the injectable solution, we can get much higher doses, much high peak serum concentrations in the body, which leads to all the benefits that we are looking at. To go over the side effects, to me personally, the biggest side effect is the post-injection pain when you're doing it intramuscularly. Now, I will briefly mention that if you have bacteriostatic water with taurine added into it, that you can find at some research companies, that to me reduces the injection pain from the glutathione and it also helps with the absorption of glutothione.
I forgot to add that into the slides, but I did want to, to that. But when we look at safety, the safety profile, some people can have mild reactions. Usually it's the post-injection pain. Some people get redness or swelling of the ejection site. Sometimes this is typically during an IV push, they're going to get brief flushing, nausea or lightheadedness. And then some will get rashes or hives or itching. A lot of times that's from, intramuscular injections and a lot of times that's just someone's immune system reacting to a foreign substance. I think you're less likely to get that if you are doing intra muscular versus sub q.
i personally wouldn't do glutathione sub Q, I know some people do and they like it and that is fine. And then also to many studies report no serious adverse events, a trial using 1400 milligrams IV three times weekly for four weeks in Parkinson's, Parkinson patients found it well tolerated. So really don't have to worry about serious safety concerns. I think it's super, super high doses. There was one case that case report documented a reversible severe liver injury after very high dose IV glutathione.
So there's that one one-off, super rare. There's an extremely rare, but life-threatening skin rash sometimes in people with Stevens-Johnson syndrome. And the theoretical concern is that glutathione injections could trigger SJS in susceptible individuals. Any rash or mucosal sores should be evaluated immediately. 2019, there were some contamination issues the FDA warned after Seven patients suffered reactions from IV glutathione containing high endotoxin levels. And then like we talked about with the UV rays, sunlight, cancer risk, I personally just would not use it as something that I would light my skin with
or push high doses to do that, especially if you're being exposed to a lot of sunlight. Now I made this little chart here for dosing. So we have general wellness. I'm typically gonna do around 100 to 200 milligrams per shot, one to two times per week. If you did wanna do skin brightening, I don't advise that, but you're gonna have to go closer to like the 900 milligrams to a thousand milligrams, per-shot. Chemotherapy support, we're typically seeing like 600 milligrams for dose, typically like every day or every other day. Male infertility, i personally recommend 200mg three to four times, for a week, That case study was 600 milligrams, but I think you can get away with a
little bit lower dose and liver disease, typically somewhere in the 300 milligrams. And we're going to do that three to four times per week. So those are my dosing parameters just based on my own personal experience. That is for research purposes only. I can just sum up for general wellness though. 100 to 200 milligrams once or twice per weak intramuscularly, I that's just enough to where it's not cumbersome or burdensome. on you, it doesn't really cause too much post-injection pain because it's a lower dose, but you still see benefits. I see pretty significant benefits in my blood work when I look at my liver enzymes.
And I honestly, too, when look in at lipid profiles now, GLPs through the years are helping improve my lip profiles. They were good to begin with because I was healthy, they just continue to improve. Again, that infertility dose is around 200 milligrams. Liver disease, 200 to 300 milligrams, and then chemotherapy higher to 600 milligrams What to monitor and best practices when we look at monitor, I would just say clinical improvement and symptom changes. Do you have any of the symptoms that we talked about today and do they start to improve?
Again, we looked at the labs, liver enzymes are going to be the biggest thing. And then we could also look. At inflammatory markers. I know Taylor had a higher HS CRP levels, probably from years of being exposed to heavy metals and toxins from doing here and SS 31 and glutathione really brought her HSCRP down and I would imagine we didn't get it tested, but probably some of those heavy metal levels down as well. Obviously for semen analysis, you're going to want to do that at a clinic. You can actually get a measure of blood glutathione levels, although I don't think that's as relevant because again, we're injecting with it and it's going
be cleared by the body and probably I didn' check, I'd imagine because it is so rare, it probably an expensive test. And then you can get oxidative stress assays, which are indirect markers. But I think a standard blood panel, we look at liver enzymes. We look in inflammatory markers through a metabolic panel. And also things like HSCRP are going to be good. Obviously, just start with a conservative dose. I thing 50 to 100 milligrams is fine. You're probably going want to work your way up to around 150 to 200 just for overall wellness. Just make sure you're doing proper sterile technique and doing it intramuscularly because that is a little bit different than a sub-Q injection.
I like to do my glutathione with a 28 gauge, half inch needle. So that's technically still an insulin syringe, but it's bigger. That's what I inject my testosterone with. And that what's I injected my Glutathion with, I think anything over that, maybe you'd get away with the 29 gauge. Anything over there with 30 gauge one, it can be big enough or long enough to doing intramuscularly. Then also too, being a larger molecule, It's a little bit more of a viscous solution, even though it is in water. It just doesn't deliver as well. Some people will do a 23 gauge I've done that in the past.
I seem to get the best results with a 28 gauge because I'll have the post injection pain that I would with the 23 gauge and it still seems to go through. Pretty good. Just to sum up, we have proven benefits when it relates to liver function and fatty liver and hepatitis, male fertility, chemotherapy, and neurological and cardiovascular benefits. When using glutathione, I think this is going to be a research area that continues to emerge if not among mainstream medicine, at least in the alternative community with us. I Think it's one of those things we talk about all these great peptides and stuff.
And sometimes we forget the more simple ones that are pretty cheap, pretty affordable and have lots of data around them. And injectable glutathione represents a powerful tool in health and longevity. And I think it's something that when we look at a longevity protocol, it should be absolutely used at least several months out of the year on a semi-regular basis. and that is it for the slides. That is my comprehensive overview of glutothione. Hopefully that was helpful and informative. Again, It's a very, very simple thing to do. Anyone that's in the world of peptides and hormone optimization Yeah, is it kind of annoying to add in another shot?
Yes, but I think this is something that pairs really nicely with all the things that we're already doing. I also think for people that are new to this world, it could be something, that would move the needle a lot, especially if we are coming from a state of really bad metabolic health or really, bad inflammation that people just kind to forget about. Not because it doesn't work, just because there are so many shiny objects out there. with someone with Lyme disease or autoimmune disease, or metabolic dysfunction or a metabolic syndrome. A lot of times we're grabbing for GLPs or grabbing these anti-inflammatory peptides, which is great to do, but I think a lot times,
we forget some of these endogenous peptide in the body and how replacing them or supplementing with them would move the needle a lot more than sometimes we probably think. I love glutathione. It's a staple. it's something that I use at least once or twice a week, pretty much every week throughout the year. And I don't talk about it that much, but again, it is one of those things when we look at antioxidant defense, what happens to the body, and what the bodies exposed to. Its an absolute must. And this actually just triggered me to think, man, I have all the supplements that I take on a daily basis that don't really talk about because they're
not peptides, but I need to get more into doing more videos on those because I think it's great to just kind of reset the basics and then also talk some of those things that people may be missing out on because there's so caught up in the latest and greatest peptide, which isn't wrong. Hey, that's what I'm, uh, love to do that too. But I sometimes it helps to kind reset and go back to some these foundational ones that everyone should be using. That's it for this one. Thank you guys so much. From the bottom of my heart, I have so many gratitude for you, guys. I really have the best audience in the world. The amount of support I get on a daily basis from you and the ability to do this work and work in this world is really a dream come true for me.
Hopefully, that comes through in content. It is apparent and I would not be where I'm at without the support of you. As always, don't forget to fill out your questions in question box which is in description of everything. Also remember to just final run to be on the email list. Again, I know I push that a lot. I don't spam you on. The email is I'm usually just writing informative emails about the topics that I making videos on, but as we've seen lately with my YouTube channel being deleted, a lotta people followed me on YouTube and they weren't on email lists and then I disappear one day They don't know what happens.
And unfortunately, that's the world we live in with censorship. Hey, it is what it. I'm not complaining. i'm going to keep doing the work and keep getting this content you guys. So just make sure you're on the email list because I do send out informative information. If ever I get deleted off any of the other platforms, It is where I will be that I can control and they can't steal from me. That's it for this one. Thank you, guys, so much.
