GHK-Cu for Anti-Aging Repair Why I Still Use It in 2025

0:09 Hey everybody, this is Hunter Williams. I hope you're doing amazing wherever you might be in the world. Today's video is going to be a little bit of a refresher video. Can you continue to put content there until it maybe gets deleted again? So anyway, but I was going back through and uploading all of the videos from the channel that got deleted onto a Dropbox folder where everyone can watch

0:43 them for free. And I have that link on my email list and everything. So you should be able to see that. But in the process of doing that, I realized like, man, some of these videos that I've done, not necessarily outdated, but they were over a year old and there's a lot more good information that I could update them with just based on things that i've learned, things I've researched, and things i have studied since then and then also to just on my own development of learning more things and being a better communicator I guess you could say. So today's video is going to be an update on GHKCU Specifically, I'm going to focus on the injectable form of GHKCU.

1:16 Now, some of the information I want to cover does talk about other applications like topical applications or serum applications of ghkcu. But I think in the world of peptides, especially for us that are like super into this, A lot of times we get shiny object syndrome. I myself am guilty of this, and rightfully so, because there's a lot things that we have good reason to have shiny objects syndrome over, cause of all the new stuff that's coming out. But sometimes we forget some of these really simple peptides that, we've known about for a long time.

1:46 We forget how powerful they are. And when we zoom out and look at the world as a whole, if you walk to the average person on the street and said, Hey, do you know what GHKCU is? Most of them are going to say no. And so hopefully videos like this that I'm making and hopefully other people are too can serve as really good basis points for people to say, wow, there is a lot of things going on with this peptide and that could probably benefit from using it. So as always, just remember we are in the infancy of this whole peptides space taking the world by storm and kind of the way that social media and all

2:17 these tech platforms work is They inundate us with stuff that they know we're interested in and we think they're like, oh yeah, of course everyone knows about JHKCU, but in reality, they don't. So that's what we are going to talk about today. Wherever this is being published, whether it's Spotify, iTunes, whatever you're listening to it on podcast forum or audio, thank you so much for supporting me. I have had an overwhelming amount of support from people during this time of the YouTube channel being deleted and everything. As always, Thank you guys so, much from the bottom of my heart. So without further ado, I'm gonna show my screen and today we're gonna do a deep dive again into GHK.

2:52 See you. All right, I'm Hunter Williams and today is all about the benefits of injectable GHKCU, which are many. We're going to look at anti-aging, healing, and even more. So in case you didn't know, GH KCU is a naturally occurring tripeptide that represents one of the most promising anti aging and regenerative compounds in modern medicine. It was actually first discovered in 1973. I am going do a little bit of talking about history of it. And it basically, uh, i think multiple people have called it the sham wow peptide. Let's look at GHKU that is naturally in the body and what happens as we age.

3:23 So at the age of 20, the average serum levels of GHk in body are around 200 nanograms per milliliter. And then when we look the the averaged person at age 60, this has dropped by 60% to around an average of 80 nangrams for milliliters at 60. We see dramatically reduced GH k levels in older adults than we do in younger adults. Again, a 60 percent loss. suggests that GHKC loss may contribute significantly to age-associated decline, and although it was originally popularized in topical skin products,

3:58 it's now gaining interest in the biohacking community as an injectable therapy for systemic benefits of which you're probably familiar with. Let's look at the broad spectrum of benefits. So first we have tissue regeneration. Now everyone associates it with skin, but what's really cool is that it stimulates repair and growth in skin. Not only skin but lung, bone, liver, stomach lining and hair follicles through enhanced cellular activity. Obviously it's known for ear growth as well. So it also boosts production of collagen, elastin, and proteoglycans essential for youthful tissue structure.

4:28 Also helps with vascular growth, so it promotes formation of new blood vessels and nerves, improving tissue oxygenation and function. It also protects our cells, it protects cells by dampening inflammation and oxidative stress while supporting natural repair mechanisms in the body's ability to naturally repair itself. So it works on kind of like these two different mechanisms. So the first one is going to be the copper delivery system. GHK has a high affinity for copper ions and can obtain copper from larger proteins like albumin and then delivers this essential mineral directly into the cell. Copper serves as a cofactor for enzymes involved in collagen synthesis, antioxidant fence and energy production.

5:04 And then also a modern analysis of the genomics of GHK reveals that it modulates thousands of genes in the body, essentially resetting gene activity to a healthier state. So it's kind of like this software program. If we look at our genes as like the hardware that can be, excuse me, if we looked at genes is like a software modulator and go and say, okay, I want to up-regulate this program and down- regulate this programs. It up regulates around 59% of gene and it down regulate around 41% among tested genes, affecting about one third of human genome.

5:34 for what we know. I still know that's one of those things that, you know, there's still a lot up in the air that we don't know about the human genome when we talk about DNA and junk DNA, and whatnot. So let's look at the body's natural repair signal. GHKCU is naturally released at sites of tissue injury when larger proteins like collagen break down after damage. This liberated GHk acts as an injury signal that triggers cascading healing responses in body. So basically what happens is an injury breaks down larger proteins containing GHK sequences.

6:04 The free GHk is generated as a natural injury signal. the repair cascade recruits immune cells, stimulates collagen repair and sprouts new blood vessels. And then the healing process is completed with improved tissue strength and function. So providing extra GH KCU via injection amplifies the body's own repair signals because all of this is going in the especially beneficial for older individuals that, like we said, have 60% less on average GHK naturally circulating in the body. So let's look at this through the lens of anti-aging and longevity.

6:38 Lauren Pickhart was the original OG of GH KCU. He was original scientist that found out about GH-KCU, eventually would go on to pioneer into formulations and products. And I think the company named his skin biology. I believe if I'm not If I'm not misquoting that, that's the company that sells his original products. But he demonstrated that adding JHK to cultures of old human liver tissue induced production of proteins typical of younger cells, essentially turning back the clock on gene expression. So we have this gene reset, so it restores healthy gene-expression patterns in aged tissues, shifting from a broken state to a regenerative state.

7:14 It also boosts collagen, enhances antioxidants, promotes DNA repair and reduces inflammation. And then we have a cellular cleanup facet of it, so it activates proteasome machinery while suppressing chronic NF-kB inflammation in the body as well. Let's also look at it under, so what GHK does under stress. So there was a University of Washington study where middle-aged mice were given GH KCU injections, 15 milligrams per kilogram per day for five days. I would not recommend the same amount if you are a person just because you don't need that much.

7:45 But anyway, they were giving these doses during sleep deprivation. And the ones that were given the GHK showed no learning impairment compared to well rested controls. So GHk treated mice's brains had lower inflammatory signals like MCP1 and nitrotiracin in the hippocampus preventing oxidative stress that typically accompanies sleep loss. If we look at this chart here, if you're watching the video, The treatment group, they had a memory performance score of 95, so that was the well-rested control. The sleep deprived plus GHK group.

8:17 So this was sleep-deprived mice, and they were administered injectable GHk. They had memory-performance score 92. so they literally only scored three points less when they're sleep deprived plus NHK. And then the ones that were sleep deprive, only they scored 65. So you can see, again, it's great that it helps your hair, its great it help your skin, and great if it helped your nails, but look at this with sleep deprivation, how much it improves memory performance. So imagine how it would improve performance if you were getting good sleep and injecting at the same time. Also too, very little known, and you know, it's funny as I'm doing this, I know one of the reasons I put this slide together and wanted to make this video

8:51 is I get emails from people all the time about like, hey, you never talk about all of these other benefits of GHK, which is true, but you start to dig into the literature, there is actually an anxiolytic or anti-anxiety effect from GHk. So when we look at this study in Ras, just 0.5 micrograms per kilogram, of an intraperitoneal injection produce potent anti-anxiety effects within just 12 minutes. So everyone's like, okay, what's the best cure for anxiety? Well, I would say a lot of times has to do with hormones. But when we look at GHK in 12 Minutes, there was a rapid onset of anti anxiety benefits.

9:26 There was 5X reduction in aggression of the mice And again, that was a very, very small, it was five micrograms per kilogram. So rats began exploring open, bright areas instead of hiding, indicating reduced fear and stress responses. This suggests that GHK might lower chronic stress hormone output that contributes to biological aging. Pretty cool. Now, wound healing. It's known much more for this, but let's talk about it. GHK's discovery traces back to wound healing. That's originally like what it was looked at for.

9:57 So when young human plasma was added to old tissue samples, it stimulated protein synthesis and healing processes and GHk was identified as the responsible factor. Basically, we have faster contraction of wounds, so accelerated wound closure and tissue repair. We have enhanced granulation, thicker, healthier tissue formation where the wound is being repaired and also increased angiogenesis. There's more new blood vessels for healing in the area of the wounds. Let's look at this in diabetic wound studies. I thought this was pretty cool. GHK treatment produced remarkable results that demonstrated its healing power across different tissue conditions.

10:30 So there was a 9x collagen increase, so there's a higher collagen synthesis in treated wounds, 100% efficacy in both healthy and diabetic rats, and there is a 3x antioxidants, there are higher glutathione and vitamin C levels, which is pretty cold that if you are injecting GH KCU, it's going to help improve natural antioxidant defenses like glutathione and vitamin C. So GHK vastly accelerated healing with better epithelial cover, increased fibroblast activation, mass cell recruitment, and elevated antioxidants substances

11:03 in wound tissue, which is pretty cool. Now let's look at systemic healing, because that was like site injury healing. So ground-breaking study demonstrated GHKCU's systemic therapeutic potential by administering injections to animals treated with cortisone, which is, as you know, a steroid known to severely impair wound repair. The cortisone dramatically impairs natural wound healing by suppressing the immune response and collagen synthesis and this creates a difficult healing environment similar to what patients on steroids experience.

11:34 Remarkably, systemic GHKCU injections counteracted the steroid's negative effects, restoring normal healing rates and tissue strength in mice, rats, and pigs. So the systemic protection suggests injectable GHKCU can reach wound areas via the bloodstream and actively promote repair even under adverse conditions like steroid treatment. And if, God forbid, you have to get a cortisone shot, it's pretty cool to know that GH KCU actually counteracts the negative effects of those. Now, I know what some of you guys are probably thinking if you're an anabolic steroid user. Well, hey, this is using GHKCU to mitigate some effects.

12:06 To that I would say probably, you know, like cortisone is obviously different than something like an aabolic steroids. However, it does make me wonder because I thought the very same thing. Let's talk about tissue regeneration. So we look at bone regeneration, studies indicate GHK can significantly aid bone healing and growth through multiple mechanisms for natural bone repair. One, we have the collagen matrix, so it boosts collagen deposition in the bone matrix for structural repair, also stimulates blood vessel growth into healing bone tissue.

12:36 We have osteoblast support, So it enhances attachment and survival of bone forming cells. Then it also results in higher quality bone tissue at fracture sites. So a lot of times when we're using this, it's healing back better and stronger than it was getting. And RAD fracture models, extremely low doses, again, 0.5 micrograms per kilogram, significantly improve fracture healing with stronger bone repair and better tissue quality, which is pretty cool. Now, this was pretty cool. We also have organ regeneration. So GHK's benefits extend far beyond skin and bone. You have liver regeneration, so it makes old liver tissue behave like young tissue, restoring healthy cellular function.

13:09 A lot of times people ask me, hey, what's a good peptide for my liver? GHk could be great. Lung repair, so it also, this is crazy. If you think about like, oh, GHK, you know, the peptide for your hair, skin, and nails, it reverses COPD damaged lung cell gene expression, restoring healthy patterns. So that's something I've talked about with my father-in-law on previous videos, but something that I get questions a lot about of lung repair and GH K works great for that. Gastric healing, so it accelerates stomach ulcer healing and intestinal lining integrity. Again, for people that struggle with stomach issues, obviously we always think of BPC, we think a KPV, TB 500, GHK works great as well.

13:45 It also promotes nerve outgrowth and the right extension for functional recovery. So when we look at people with like nerve pain, nerve issues things like that GH K does good for that too. Let's talk about the COPD study. So in this study, GHK was able to reverse the gene expression signature of COPD lung tissue, shifting it from a destructive emphysema state toward a regenerative healthy state. So this demonstrates the ability to restore healthy function even in tissue severely damaged by age or chronic disease. It also provides a younger signal to mature cells encouraging developmental healing capacity.

14:16 Let's look at inflammation and targeting inflammation. A 2025 study on ulcerative colitis demonstrated GHK's potent anti-inflammatory effects and severe inflammatory disease model. So the results were markedly less inflammation and tissue damage, reduced weight loss and disease severity scores. I think this is the key here too when we talk about some of these gut in inflammation or autoimmune type. issues is it suppressed key inflammatory cytokines of TNF-alpha, interleukin-6, and inter-leucin 1-beta and restored protective gut barrier proteins and

14:47 also increased mucus producing GABA cells. So by reducing inflammatory signals while enhancing tissue repair, it led research to conclude that GHK has significant therapeutic potential in colitis and other inflammatory conditions in the sun. When we look at this, we have the multi-pronged approach to killing inflammation or suppressing inflammation. So we had gene suppression to down-regulate to NF-kappa-B and pro-inflammatory genes. We have cytokine blocking, so it reduces TNF-alpha, interleukin-6, and other inflammatory mediators.

15:19 We also have an enzyme boost so it increases superoxide dismutase and antioxidant enzymes. Also we have antioxidants so neutralizes toxic oxidation byproducts and free radicals in the body and so by keeping inflammation in check GHK provides collateral tissue damage and accelerates the resolution phase of healing creating optimal conditions for regeneration. Now cognitive support, I mentioned this a little bit earlier, but let's talk about it a bit more. So we have the anxiolytic effects. Like I said, 0.5 mg per kilogram administered intraperitoneally.

15:50 There was a five-fold reduction in aggressive behavior under stress and also the onset happened in 12 minutes. We also have that sleep study where the University of Washington looked at it to where sleep-deprived mice scored almost as good as the non-sleep- deprived mice when they were injected with GHKTU. Also, to add to that, there was a preliminary trial that showed intranasal GH KCU. So yes, if you wanted to, you could use intrasnasal. Now, I personally haven't done that and it might burn if I do it, so just be careful.

16:20 It should improve performance in spatial learning and memory navigation tasks with treated mice navigating mazes more effectively. There also is a pain relief aspect to it, which if we are using it for healing, obviously, like there's going to be like when something heals, there is going be a Pain Relief aspect too. But let's look at that. So at a 0.5 milligram per kilogram dose, GHK extended pain tolerance in hot play tests compared to established analgesic compounds. Gene analysis shows that GH K up regulates mu opioid receptors and cannabinoid receptors involved in natural pain Relif.

16:50 And I think as opposed to some of the other peptides, you know, BPC, TB 500. We look at this, it's helping with this cannabinoid receptors involved in natural pain relief and that's where we're getting some that and also to it increases genes for oxytocin and nociceptim that modulate pain perception through natural pathways, which is pretty cool. Now cosmetic applications, let's talk about that. So, When we look at control trials demonstrating the effectiveness of skin rejuvenation, often outperforming established anti-aging.

17:20 So we had topical GHKCU cream, there was 70% new collagen formation. We had vitamin C, which was around 50% and then we retinoic acid, which was around 40%. So in landmark studies, it performed both vitamin C and prescription tretanin, and I know I'm not saying that right, ladies, but in stimulating new collagen formation, achieving superior results without irritation, We also see when we look at the topical use for skin transformation. So there's been marked 55.8 reduction in wrinkle volume, significantly outperforming other peptide treatments.

17:57 It does improve skin firmness, so it increases skin thickness, density, and elasticity through collagen and elastin production. Also to it evens pigmentation. This is a question I get a lot, even something that I struggle with. If you look really up close in the camera, sometimes I'll have like uneven pigments. pigmentation from like sun or whatever on my face or other spots of my skin. So it fades hyperpigmentation and sun spots while improving overall skin clarity and tone. We could all, including myself, use some GHK. Look at hair growth. Obviously, this is a big one. You know, just as a quick aside, when it comes to hair growth, I can talk about it and I present information about and know intellectually stuff about.

18:34 A lot of times I would be lying if I said that I feel bad sometimes. because like I've never struggled with hair loss in my life. And there's a lot of guys, women too, but a lotta guys ask me like, hey, what peptides can I use for hair growth? I can speak to it. But sometimes I'm just hesitant to speak about things I don't have personal experience with. Unfortunately for me, I have at least thus far in life not experienced any hair lost and I grow hair like crazy. So that's also a genetic thing. Like all of my grandparents have tons and tons of hair on both sides of family.

19:07 Even one of my grandfathers, he died, you know, probably 12 or 13 years ago now. But he, in his early 70s, was doing chemotherapy and still had hair coming through while he was chemotherapy. So just one those things like the genetic piece is big to it. When we look at hair growth, we have follicle enlargement. It actually increases hair follicles size and length for thicker hair production. Also to when I'm saying this, yes, when we're looking at this we are talking about like serums and creams, but I do think injecting GHK to you could be

19:39 beneficial for hair growth. And I even have heard of people inject it actually into their scalp, which I know has got to burn, But I think people do it. There's also growth phase extension, so it prolongs the antigen phase, keeping hair in active growth longer. It also enhances blood supply to follicles through angiogenesis. Also reinforces follicle structure with increased collagen support and studies show that GHK performance comparable to 5% minoxidil solution in promoting hair growth with additional benefits for transplant success rates. So, If you want to go down the DHT blocker rabbit hole and use those products, I would highly recommend that you don't.

20:16 Not a fan of that. I'm not telling you how to live your life. However, in studies, there are studies to show that it was comparable to minoxidil 5% solution. So I wouldn't at least give GHK a try before you go on the DHD block route because There's so many bad things that can come from that, whereas like GHK, obviously we are looking at things like there's not really anything bad that is only good that we know of. So we look at clinical applications of future potential. GH K's versatility and safety profile is a transformative therapeutic tool across multiple medical disciplines.

20:49 We have orthopedic surgery, so it's obviously can accelerate healing and ACL repairs, tendon grafts, and fracture recovery through enhanced tissue integration. We have gastroenterology, so it treats stomach ulcers and inflammatory bowel disease by promoting mucosal healing and reducing inflammation. We can also reduce organ damage after trauma or sepsis through self-productive and anti-inflammatory effects. And then also we can use it as injectable mesotherapy for intensive skin rejuvenation and hair restoration treatments for aesthetic medicine. So where is the future of GHK?

21:20 Hopefully much bigger and much stronger. I would say out of all the peptides, it definitely is one of the more entrenched ones in terms of like if people know about peptide, a lot of times they know We have a very strong scientific foundation, perhaps if even more so than some of the other popular peptides. We definitely have more scientific data on GHK than we do on GLPs, that's for sure. More people are probably using GLP's, but it's an excellent safety profile really, other than the fact that when you inject it burns, not really anything to be a downside of. Multi-system benefits and holistic repair.

21:50 So from a plasma peptide that made old liver act young to a multi-domain therapeutic, GHP exemplifies how unlocking our body's biology secrets yields powerful interventions. And the story continues to expand as research expands in new applications for healthy and healing and aging. So that's it for the slides. And that is my updated 2025 video on GHK-CU. As you can see, lots of data and studies out there to show all of these various benefits of GHk.

22:20 Even doing this video and doing the research for this videos like, man, I haven't used GH K in a while because I really had the need to, but it is one that I think periodically throughout the year, everyone should have in their protocol, whether you need it for injury purposes, Whether you needed for beauty purposes hair purposes aesthetic purposes or you just want to have something good that helps with anti aging and The cool thing now is we have the Globlend, which is GHK with BPC and TB500. We have GloBlend which has GHk with KPV, Bpc and tb500 and so you can knock out and get the benefits of multi-peptides without having to inject three to

22:54 four times per day and you know just use one injection because it comes in a single vial. As always, you can check that out. I will say guys, just to close out, first of all, thank you guys so much. When you go through times like this where it's really, really hard because your YouTube channel gets deleted and you feel like your life's work is not worth anything because the powers that be don't want it out there, which I know is true, but it is one of those things you struggle with mentally. cool being vulnerable with that and just being transparent with you guys. It can be really, really tough taxing when you do all this work and make this your life's work.

23:27 And it's not always accepted and things like that can happen. So I'm not going to sit here and tell you it is not hard emotionally, mentally and physically. to go through, but the saving grace and silver lining in all this is the amazing support I have from the people that watch videos, the readers on the email list and everything. So that point being is please be on that email lists because that is, one saving graces in this all is like if my channel gets shut down and have to make new ones or anything. The email is something that I own and I can control and use to communicate with you guys.

23:57 I'm not trying to do that to sell you or spam me or anything. Of course, I do have affiliate links and stuff like that in the emails because we all got to make a living in third density. But please just know that that is the one way that I can communicate with you because at the end of the day, YouTube, Instagram, Facebook, TikTok, Twitter, blah, all these things, everyone has to have an email address to operate in world today. And really if you want to do anything on the internet, you have to have an email address. And so that's the one thing that I can have that lets me interact with my audience and keep information updated with you guys.

24:28 So thank you, guys, from the bottom of my heart. Again, I'm just so overwhelmed with gratitude for the amount of people that support and help get this mission out there and know that if you're watching this, your as instrumental in this movement as I am. Even if, if never make content, but just sharing it, getting out Talking to your friends and family about this stuff is huge because that is a mission, is to use tools like GHK to help change the world. So thank you guys. That's it for this one. If there is place to leave comments on Spotify, I think you can leave comment on spotify. I'll check those out.

24:58 And yeah, thank guys so much. See you in the next one, peace.