Ipamorelin - The Gateway Peptide Everything You Need To Get Started
Summer is coming, and I know everyone is trying to get their beach body ready. So I want to walk you through the exact peptide stack I'd hand someone who wants to lose the most fat possible. This is my starter kit. The agents, the doses, and a daily schedule so you actually know when to take what.
Fat loss happens by hitting multiple pathways at once. This stack covers them.
Ipamorelin
Ipamorelin is a growth hormone releasing peptide. It stimulates your pituitary gland to release your own natural growth hormone. That helps you sleep better, feel better, and support muscle mass.
More muscle means a higher metabolism and more efficient fat burning. When you go into a caloric deficit, you tend to lose muscle along with fat. Ipamorelin helps protect that muscle while you lean out.
Common dose is 200 to 300 micrograms per day. Women start at 200, men start at 300. You take it first thing in the morning, and you can also use it before fasted cardio for an extra fat burning boost.
Tesamorelin
Tesamorelin is another growth hormone releasing peptide, but it specifically targets abdominal fat. It got FDA approved for visceral fat reduction in HIV patients with lipodystrophy, and now plenty of people use it to attack stubborn belly fat.
Why run two GHRPs? In a perfect world I'd use exogenous growth hormone. These peptides are a much cheaper entry point and they work.
Dose is 1 to 2 milligrams per day. Women start at 1 mg, men can go up to 2 mg. Take it before bed. This one also helps with deep sleep, which matters more than people realize when you're cutting.
Tirzepatide
Tirzepatide is the GOAT of GLP-1s in my opinion. I just started using it again three weeks ago at a small dose to lean out for summer.
It's a dual agonist. It hits both GLP-1 and GIP receptors, which means it suppresses appetite and helps you burn fat more efficiently. I think it's stronger than semaglutide for fat loss.
Start at 2.5 milligrams per week. I don't care how much weight you have to lose, start at 2.5. Your body builds tolerance over time, and that's when people titrate up to 5, 7.5, 10, even 15 mg per week. If I took 15 mg, I'd barely be able to eat 200 calories a day. Slight exaggeration, but you get it.
One injection per week, fasted, and don't eat for about 90 minutes after.
Tesofensine
Tesofensine is a triple reuptake inhibitor. It works on serotonin, dopamine, and noradrenaline. It crushes appetite and over time it actually increases your base metabolic rate.
You won't notice the metabolic increase in the first 60 days. After 6 to 12 months of consistent use, you will.
Most protocols start at 500 micrograms. I recommend 250 micrograms per day. Some people can't sleep at all on 500. Start low and see how you respond.
Take it first thing in the morning. That avoids any insomnia issues and helps suppress appetite all day, especially if you're fasting.
5-Amino-1MQ
5-Amino-1MQ is an NNMT inhibitor. By inhibiting that enzyme, it raises NAD+ levels in the body. Higher NAD+ means more efficient muscle building and more efficient fat burning.
Start at 50 milligrams per day. I go up to 150 mg, but I'm a bigger guy. 50 mg is the right starting point for most people.
Take it daily. Morning is fine, pre-workout works well, or split it into two doses. It won't keep you up so timing is flexible.
Injectable L-Carnitine
People sleep on injectable L-carnitine. It transports fatty acids into the mitochondria where they get burned for energy.
When you do low intensity fasted cardio, you want to burn fat, not glycogen. That's why we don't do high intensity work fasted. L-carnitine pushes that fat oxidation hard.
Start at 500 mg intramuscularly, four to five times per week. You can titrate up to 1000 mg. I usually do it on fasted cardio days, sometimes before resistance training.
You'll feel a heat pulse through your body, you'll sweat way more, and you'll feel better the next day. Oral L-carnitine works too, but you'd need around 1500 mg, and the injectable form is far more potent.
Metformin
Everyone loves to hate Metformin. Give it two months.
The reason people quit is GI discomfort in the first couple weeks. That's because it's reshaping your gut microbiome. Push through it.
Metformin improves insulin sensitivity and reduces glucose production in the liver. Better insulin sensitivity makes fat loss much easier. It also pairs really well with Tirzepatide.
Start at 500 mg in the morning and 500 mg before bed. I take 1000 mg twice a day. You can take it with or without food.
In my opinion, Metformin is one of the most powerful anti-aging medications we have access to.
The Daily Schedule
Here's how it all comes together.
Morning
- Ipamorelin, 200 to 300 mcg
- Tirzepatide, 2.5 mg (once per week, pick a consistent day)
- Tesofensine, 250 mcg
- Metformin, 500 to 1000 mg
Pre-workout or pre-cardio
- 5-Amino-1MQ, 50 mg
- Injectable L-carnitine, 500 mg
Evening before bed
- Tesamorelin, 1 to 2 mg
- Metformin, 500 to 1000 mg
I train with weights Monday, Wednesday, Friday and do fasted cardio on Tuesday, Thursday, Saturday, Sunday. On fasting days I'll go anywhere from 24 to 36 hours.
The Tesamorelin at night matters for sleep. When you're in a caloric deficit, cortisol goes up. High cortisol blocks fat loss and tanks your sleep quality. Tesamorelin helps push you into deeper sleep cycles, which is crucial when you're cutting.
My take
This is what I'd hand a friend who wanted to get serious about fat loss with peptides for the first time. Every agent here hits a different pathway. Growth hormone for muscle protection, GLP-1 for appetite, tesofensine for neurotransmitters, 5-Amino for NAD+, L-carnitine for fat oxidation, and Metformin for insulin sensitivity.
You don't have to run all of it on day one. Pick what fits your budget and stack from there. Diet and exercise still matter, but they don't have to be complicated. If you want the deep dive on the science and the protocols, the book I wrote with Jay Campbell, 30 Days of Shred, has all of it.
Full transcript click any paragraph to jump video
Hey everybody, this is Hunter Williams. I hope you are doing amazing wherever you're out in the world. Today's video is going to be the ultimate fat loss peptide stack. So I know a lot of people will have been anticipating this, but what I'm going do today is go through and break down all of my favorite peptides and some other agents that are not necessarily peptids that I would use in a fat lost stack now. There are tons of different things I would use for fat loss, but I'd say if I wanted to give people kind of like a starter kit to lose the most fat possible with peptides, it's going to be this. So what I'm going do is just walk through all of the agents that are going be in this stack as well as explain how you would used them over the week.
At the end of video, after I walked through agents and their dosage and everything you need to know about them, I am going explain like Monday, Tuesday, Wednesday, not necessarily on a daily basis, just like what you take in the morning and then in middle of day and in evening. This should be like a good overview of what you need for fat loss. And especially now with the summer coming up, I know everyone is trying to get in their best shape to have their beach bodies ready for the Summer. So I'm just going to walk through all of that. I think you'll find this really helpful. Fat loss is kind of like hitting all these different pathways that we need to address.
Hopefully this video will do that with some different peptides and agents that I personally use. myself when I am leaning out for summer. So what I'm going to do is share my screen. And as always, if you guys want the peptide cheat sheet, that link will be down in the description. You can check that out. Then also too, I have my book behind me that I wrote with Jay Campbell. It's 30 days of shreds. If you want all the deep dives on the science behind all of this and like the real nitty gritty, it's a 420 something page book that has all this that,
you know, like I if you want my insights on that. So without further ado, what I'm going to do is share my screen and we are going All right, so this is going to be the ultimate fat loss peptide stack. So we're gonna walk through everything you need to know to get started. This is gonna be very brief and to the point. The first role, or excuse me, the first agent I have in this, is ipamerelin. Now, ipamerelin is a growth hormone peptides. It basically is growth-hormone-releasing peptid that can stimulate the pituitary gland to release growth hormones.
And this action can indirectly lead to fat-loss by increasing muscle mass, which in turn boosts metabolism. so the way ipamarelin works, Basically stimulates our body's own natural growth hormone production. It's not actual growth, hormone itself. And then doing so we're going to sleep better. We're gonna feel better, we are going help support muscle mass and in the support of muscle, mass we going burn more fat. So the more muscle our bodies has the efficient we gonna be. at burning fat. So a lot of people will look to the GLP ones, which I'm going to get to in this video.
But when it comes to fat loss, muscle is one of the most important things we can do. And as we are trimming fat off of our body, one thing that tends to happen when we go into caloric deficit is we also lose muscle. But when we use a peptide like epimerelin to increase our body's natural growth hormone, it's going to help us burn fat. So basically the common dose is 200 to 300 micrograms per day. If you're a woman, I would start at 200. if you were a man, i would started at 300 and see how you feel from there. But women can definitely take 300 grams per Typically that's going to be administered two to three times daily. Now hold your horses.
I'm going get to like exactly when to take this along with all the other ones towards the end of the video, or you can skip to that point, you know, in the chapters. And we're going explain that. So, people often take it before bed to maximize the natural process of growth hormone or pre-workout to utilize growth from a release for enhanced metabolic effect. Now, um, I'm going to talk more about that, you know, as we get later in the video, but just know for all intents and purposes, it helps us boost growth hormone, which helps support muscle, Now, next one is going to be tessameralin.
So tesamalin is also a growth hormone peptide. Now you're thinking, Hunter, you just said a Growth Hormone Peptide, well, yes, we're going use both of these together. In a perfect world, I would use exogenous growth hormones. That's what I do. But I like these, one, because they're cheaper, relatively speaking, than human growth hormonal itself, especially if you are getting the Growth hormone via prescription. But they're cheaper and I think they are a much better entry point for people to get into peptides and see what they do. And then maybe move to a growth hormone at some point in the future.
So, Tessamereline is another GHRP, which is a Growth Hormone Releasing Peptide, that specifically targets abdominal fat, making it popular for reducing visceral fat in a context of HI-associated lipodystrophy. That's what Tessemereland got approved for. It's helping guys that were HIV positive that would get visceral fat and their lower belly region. to help burn through that, but it is also used by lots of other people to decrease abdominal fat. So the typical dosage for this is going to be one, two milligrams per day. For a woman, I would start one milligram.
If you're a man, you could do two milligram, and obviously, too, it's one of the affordability things because Tessamerelin is obviously more expensive. You're usually going take this before bedtime. I'm going talk about why we take it tomorrow in the morning and then Tessa at night before bed. Next agent is going to be Terzapatide. So Terzaapatde is, in my opinion, the goat as it gets to, you know, GLP ones. We do have Reddit True Tide out now, which I'll be doing a video about in the future, but I love Terzerapatte and I actually just started using it three weeks ago for the first time in like six months.
um, just to, you know, lean out for summer and I'm doing it at a small dose. Um, but that's what search appetite in a nutshell works by mimicking and cretin hormones, which affect insulin secretion glucose regulation and satiety. So it is shown significant efficacy and weight loss by reducing the app, reducing appetite and improving metabolic function. What I love about search, appetite is a dual agonist, meaning that it's a GLP one aganist. It helps raise the level of GOP, one hormone in the body. It's also a GIP, which I believe stands for gastrointestinal peptide and helps raise that.
Don't quote me on the G.I.P. I know it's a gip agonist, I forget exactly what that stands. But basically just know that it works to help increase not only satiety by making you feel fuller, but also helps increase glucagon-like peptide to, or excuse me, that's GLP, but GIP, to help burn fat more efficiently. So that why I like it relative to semaglutide. Not that semoglutaride doesn't work, I think trzapotide is a little bit stronger in the department of fat loss itself. It works to suppress appetite, it also works better for fatloss, in my opinion.
Doses can vary. They're gonna start around 2.5 milligrams per week. Now I have seen people up to 15 milligrams a week of trizapitide, You definitely do not want to start that high. I would say everybody, regardless of where you're at on your fat loss journey, you know, even if you've got a few hundred pounds to lose, start at 2.5 milligrams because that's a great starting dose and you want see how your body responds. Now what happens is over time, your buddy builds up a tolerance to it. And that why people have to titrate up the dose to five milligrams and seven and a half milligrams, and 10 milligrams. Then I've seen people on 15 milligrams per week.
If I, if I used 15 kilograms per a week, I probably like only be able to get down like 200 calories per day. That's exaggerating a little bit, but that's just how strong that would be. But two and a half milligrams for a week is a great starting point. And you're only going to do this one time per week. So when we inject this is just once per we per-week. I prefer it in a fasted state. You can take it, you know, with food though. Some people do, But with all peptides, I'm going say, take, it on a facet stomach.
and then also make sure you don't eat for like 90 minutes after that. So next one is going to be tesofensine. I love teso-fensin. It is basically a triple reuptake inhibitor, meaning that it helps with the reuptake of serotonin, dopamine, and noradrenaline It's been primarily studied as a treatment for obesity and Parkinson's disease, but it helped reduce the appetite and increase metabolism. Basically what that means is that when you increase those neurotransmitters in the body, it's going make you less hungry, And thereby, you're not going to want to eat as much.
And over time, it also increases metabolism. Now, It's not really going do that, in the first 60 days, but it's one of those things like after six months, after 12 months when you are taking it that you'll start to notice a real increase in your base metabolic rate. You know, most doses are going to start at 500 micrograms. I recommend 250 micro grams per day. The reason being is that I personally get the best benefit, you know 250 mcg. If I take 500 mg, it does maybe impair my sleep a little bit, but I know to people that take five hundred micro-gram or half a milligram and they just
can't sleep at all. So, if you've never used it before, I've seen a ton of variation in how people respond to this. So start low, 250 micrograms per day. I have a whole video on testophane seen on my channel just because it's one of those more complex supplements, but you're going to want to take this first thing in the morning right when you get up, and that's going help avoid any potential insomnia and then also work to suppress your appetite throughout the day, especially if your doing fasting. Um, like I recommend in all the diet protocols, you know, the J and I spouse.
Next one is going to be five amino one M Q and, uh, basically five Amino. I've made videos about it, but it inhibits an enzyme that blocks nicotinamide adenine dinucleotide, which is an AD plus, thereby enhancing metabolism and potentially leading to weight loss. Now that I read that out loud, I think I put a typo in because 5-amino-1MQ, it's an NMMT inhibitor, so it inhibits NMMT and then that in turn raises levels
of NAD+. So that's my bad in the slides there, but just know for all intents and purposes, 5-amino-1MQ is an NMMT inhibitor and thereby it raises NAD+. And when we raise levels of N80+, we're going to build muscle more efficiently and we are also going burn fat more efficient. So most people are going start at 50 milligrams per day. I like going up to like 150 milligrams a day but I'm also a bigger guy. But I just tell everyone to start with 50 mg per days and then kind of go from there.
This is going to be typically taken daily. I like to take it in the morning, but you can take in a morning you take before your workout or if you were to do like two doses like if he wanted to 50 milligrams twice a day you could take one in morning and one at night or one of the more than one before you work out but this one is not really doesn't matter as much to when you taking stock like keep you up or anything like that. So the next one is injectable L-carnitine and people sleep on injectible L carnitin. I've talked about it in the past.
If I don't have a video on my new YouTube channel, I'll definitely do one. But basically, L-carnitine helps transport fatty acids into the mitochondria, where they are burned for energy, promoting fat loss and increased energy during workouts. So basically just think of injectable L carnitin works not only for mitochondrial health to help you with improved energy levels, but it works really well at helping you oxidize fatty acid, which means burn fat. So, when you think about like exercising, you kind of go from the state where you burn carbs to burning fat, and we're doing things like fasted cardio,
we want to burn fat and not carbs. And that's why we don't do high intensity fast and cardio. We do low intensity faster cardio because we wanna burn those fatty acids, um, not tap, uh, glucagon or glycogen stores. Excuse me. Um, to put our body in a state, where we were going to need to replenish glycol stores and eat food. So that what we do fast to cardio but, Typically, you're going to start with 500 milligrams injected intramuscularly, typically four to five times a week. You could do this every day if you wanted to. I like to do it just like on my fasted cardio days.
Sometimes I'll do before a workout too, and it works really well. If you do a resistance training session, it'll help you sweat a lot more. But I always say people, if your doing a fat loss phase, use 500mg and then you can titrate up to 1000mgs of injectable L-carnitine before that. And you will see phenomenal results you'll notice like your body has this heat pulsing through it that feels really good and it's burning so much more fat you're going to sweat a lot more and then you notice the next day it is so better.
So I am a huge fan of injectable L-Carnitine. You could take oral L carnitin typically what I would do is probably close to 1500mg if I was taking it orally. But it's just the benefits of injectable are so, so much more potent than the oral L-carnitine. Injectable L carnitene, I always forget to talk about it, but it is such a powerful compound. So the next one is going to be Metformin. So metformins is one of those that everyone loves to hate for whatever reason.
I always tell people like give it two months and see how you like it. And if you don't like, you can always stop. But the reason most people don t do it is because they're like oh, it causes me to have upset stomach. Well, the reasons is, is it's cleaning out your stomach in such a powerful manner that a lot of people get diarrhea or constipation when they first take it because it s changing their microbiome so much. It's used primarily, obviously, to manage diabetes, which that's just a whole different conversation about quote unquote managing diabetes.
But it contributes to weight loss by improving insulin sensitivity and reducing glucose production in the liver. And Metformin, when we look at fat loss, we want to look it like muscle support. We want a look a appetite suppression. Basically, like the ability to oxidize fatty acids. So that's all those pathways that I just talked about across those agents before, or previously, and metformin is going to work on the insulin pathway. Now, Terzapatite does this a little bit and I always recommend people use met formin in conjunction with her's appetite to maximize the results.
So all of these are kind of like coming together to work synergistically. But basically Metformin is going to help with insulin sensitivity. The recommended dose is 500 milligrams to start. I take 2000 milligrams per day broken up into two doses. so I'd take a thousand milligrams in the morning and a 1000 milligrams and evening before bed. If you're just starting with it to assess your tolerance level, I would start with 500mg in morning, and 500 mg before bedtime. If you have a dysregulated microbiome, which most people in the first world do have, you're probably going to have to get through a two week period where
you don't feel the best in your stomach and you might have GI discomfort, but I promise after that Metformin is the most powerful anti-aging medication. And in the context of fat loss is going to help you with insulin sensitivity, which makes it way easier to lose fat. So it's usually taken with meals. Now I do this, you know, when I'm fasting, but you can definitely take it with meal as well. It's not really one of those ones you have to worry about, taking it without food. So what does the daily schedule look like when we are talking about all of these agents?
So, what I wanted to do with this fat loss stack is just basically give you like a daily scheduled of like, okay, What does a morning look? Like what is the, you know, midday look, like it was the evening look. Like, so the first thing we're going to in the morning is administer 200, 300 micrograms of it from Rellon. And that's going help boost natural growth hormone secretion throughout the day. So that's going to be first thing in the morning. And if you're going do fast cardio, you can do it before fasted cardio as well. It helps to increase the fat burning and it's gonna come from that. Next one is going be Trisapatite. Now, like I said, this is only once per week injection.
So just choose a morning that you do consistently. You could do Monday. I always do mine on Tuesday because Tuesday is usually a fasting day for me and I like it because it helps make fasting easier on those days. So take it in the morning and it's best to be taken, you know, like on an empty stomach. And then testo-fencings, so you're going to take that every day. You know you can start with 250 micrograms and maybe work your way up to 500 micro grams. But basically, that's going be something you take every and then obviously we have our Metformin that we just discussed with 500 milligrams in a morning
to start. Then, work you way to 1,000 milligrams like I take everyday. And then what we're going to do before our workout or cardio. So depending on the day of the week, for instance, I train with weights three times per week and then I do fasted cardio on those other days. It's like Monday, Wednesday, Friday. I lift weights Tuesday, Thursday, Saturday and Sunday. And you fast at cardio and fast on. Those days from anywhere between 24 to 36 hours. Um, so I may eat a meal or I made not eat meal on my fasting days, just depending how intense I want to be.
But basically before my workout or cardio, I'm going to take my five amino one MQ, which you know, you're going start with 50 milligrams work your way up to maximize metabolic activation. And then the injectable carnitine works really well right before that, resistance training session of the cardio. If you could only do one, that would do the Cardio, but you can do it before both like I've talked about. Then in the evening, we're gonna take our Tessamerelin. So there again, this is the growth hormone peptide. So we're gonna inject one to two milligrams depending on your size and how much you can afford to target that abdominal fat before bedtime.
That's also going to help us sleep really well. So the reason we want that in there for sleep too is because typically when we are in a caloric deficit and we trying to lose fat, we doing more cardio and don't have as much food and the body increases the amount of cortisol it secretes. Well cortisol inhibits fat loss, meaning it makes it much harder to loose fat. And in doing so, when our cortisol levels are elevated, we tend to not sleep as well. And that's why a lot of people are chronically stressed out. They don't sleep, as what, because they have high cortisol. So Tessamerelin is going to actually help get us into a deeper sleep cycle, which is crucial for fat loss.
That's like another, you know, it does help with that loss by increasing muscle, Which increases fat lost, but it also really helps with deep sleep. Which is gonna be that much better for that lost. And then last, we were going to have our Metformin that we're going take before bed. So we've got 500 milligrams to start and then work your way up. It's going help with insulin sensitivity and reducing hepatic glucose production throughout the night. That is the ultimate fat loss stack. If I were just getting started with someone, that's everything that I would tell them to take. Let me close out my slides.
And that's the ultimate fat loss stack when it comes to peptides. Now there are lots of other peptide that help with fat. Again, I could have put thousands of different things on there, but this would be kind of like my go-to starter kit. Like I said, for someone that really wants to like get into peptids for the first time. So if you're ordering peptid, you are trying to figure out what to do. You know, mentioned a little bit about the diet and exercise stuff. That's a whole different conversation for another thing, but it's also very simple. Uh, the diet and exercise for fat loss does not have to be complicated. And like I said, if you want like the whole complex guide with everything, you can get the book 30 days of shreds.
Um, You know, If you're on the email list and stuff, there's probably ways you could get to PDF for free. I'm sure that's out there. But you know that on Amazon, can you get kindle version or the hardcover edition as you see behind me on amazon. Yeah, that is the ultimate fatloss stack. Let me know what you guys think. If you have questions, if I left anything out in this video, definitely let me down in the comments below. Um, you know, I'd be more than happy. I'm doing my best. The comments are getting, um, You know quite numerous on the channel, which is amazing. And I love you for that. But it's just not as easy to respond.
So what I want to try to do, not try what i'm going to is just take all the comets that I get and put them onto one document and then just do the Q and a videos. Cause those seem to have done really well. So that's all I got for today. Hopefully that was helpful and informative to you guys. Like I said, if you have question, comment, concerns, let me know. And then as always, sign up for the email list. You can download the peptide cheat sheet or my supplement sources list, and that the best way to stay in touch with me and also to avoid any of the shadow banning and future stuff that may come from the powers that be. So I love you, guys, so much.
Thank you for everything,