Peptide Q&A · April 2026

0:01 The end. Hey everybody, this is Hunter Williams. I hope you're doing amazing wherever you might be in the world today, I am doing the April 20, 26 Q and a video. So today I'm going to go through all of the questions that I got sent in.

0:31 The last month, it feels like just yesterday that then I did the March one, even though I think I published the march one. It was like April 2nd or April 3rd or something just because of scheduling. But anyway, Today I'm going to go through the questions for April 2026. So thank you so much for being here. As always, before I get into these, I just want you to know that the question box is always going be in the description of the videos, wherever you're watching this, whether it's Spotify or on YouTube. And then also too, if you are on my email list, there is a link in a footer of those emails to submit me a question.

1:01 And I love doing these. Hopefully you enjoy watching these as much as I enjoy making them. Because to me, this really tells me what you guys need help with and what guys struggle with. And then I can shape my content accordingly, whether it's my deep dive videos or just these Q&A videos. So I really love these, I've got all of them printed out on some paper right here. And so we're going to go ahead and rip through them. As always, just before I get in, make sure that you're on the email list. That's the best way to stay in touch with me in case censorship begins to take over again. And then also too, if you would like to join my private group where you can ask me live questions every Thursday night on a call,

1:35 or you. Can message me privately anytime and get your question answered. The best place to do so is our private. Group is called the Axion Collective. It's 99 bucks a month and you cancel anytime. Link will always also be down in the description. So. Without further ado, let's break these up. The nice thing about these questions is I found a really good groove with some of the AI tools that I use that can take all the questions that get put them into a document, which I've printed off right here. And I can also categorize them by category so that when I'm doing these videos, because the question's obviously do come in randomly,

2:05 I could group them category and kind of go through each category. So for the sake of organization, If you're like me and you are organized, it's a little bit more thematically structured in a format that is kind of lined up by category. So let's get into it first. We're going to talk about some women's health and hormones. Question from Amanda. She says, I'm a woman on TRT. Would adding kiss pep and helped optimize results further for libido and muscle gain or is that overkill? In my opinion, In addition to TRT, I don't know that kids' peptin is really going to help with muscle gain.

2:38 However, there are some cases, especially with women and with men, that can definitely help for libido. So I make no illusions that kid's pep is a replacement for testosterone, nor would I say that it's going put on the muscle that even like a growth hormone peptide would in addition the testosterone or growth hormones itself. However, I think for libido purposes, uh, i personally have experienced that there is a brief pickup on libidio within the few hours after injecting kisspeptin. It's not something that lasts over a period of time, but if you're injectting it, there's a little brief libida boost there.

3:08 And there are actually documented data around that, that people that are shown erotic images are more likely to respond to those, I guess, in an arousal way when they are on kisspeptin versus not. And so there is data for there. I personally anecdotally can verify that. So I would say it could help with that, but I wouldn't view it as something that is like a long-term solution. For the libido case, it's going to be a short- term solution, and then even for the muscle gain, is not really going do anything anyway.

3:39 That's just my experience. Next question from Adori. She says, my free testosterone doubled after starting GHK-CU while on HRT, but I'm not feeling any symptomatic changes. No strength gains, no hair loss, and no libido shift. Should I reduce my HRP dose or is this likely transient? I think it's likely transient. I mean, that's great. If your free-testosterone doubled from the GHk. Now I realize some women might not want their free testosterones too high because they may or may not get viralization symptoms out of that. However, I would say that it's likely transient.

4:10 A lot of the times the free testosterone can kind of be transiently up or transient down depending on SHBG. My guess is that if this happened, the GHK was actually improving the environment inside the body to lower SHPG if it had been too high before. And so that's my guess as to what happened. But that would be my recommendation is I wouldn't really do anything, especially if You feel good, although I know it may be confusing if you're not having any strength gains or changes in libido, but I wouldn't change anything if Next question from Erica, what do you consider the truly optimal estrogen and

4:46 testosterone levels for women is 200 on testosterone on the target? I would say most doctors that are in the HRT world will tell you that 200 is usually the baseline where women will see vast improvement in symptoms. And so it's not that a woman can't be under 200, she could be like 150 and probably feel pretty good, but most women at 200 and beyond, their total testosterone, that's where they start to feel really good. As far as estrogen goes, kind of depends on if you're pre menopausal, that's going to fluctuate even on testosterone. And so I will say somewhere between like 75 and 150 for a pre-menopause woman, they're usually going feel good.

5:20 For post-manopasal perimenoposal I would say anywhere between 125 to 150 is where I like to see it. That's where a lot of women feel really good there. And so I would say kind of 200 is the minimum for your total testosterone. Then if you're pre or excuse me, peri or postmenopausal, like 125 to 150 is a good spot for estrogen. Estrogen is going to be more variable in the sense that everyone aromatizes differently. Especially for post menopause women, some of them need to add in estradiol in addition to what they're already doing with their testosterone,

5:51 and some don't. Some get enough estrogen out of their Testosterone. That kind has to have to a personal decision between you and your doctor, but that's my thoughts on it. Alinka says, can you cover peptides for women focused on health optimization and longevity? Yeah, I guess that's kind of what I do with my channel. I will say for woman, think about it like this, and this goes for men too. Hormones first, so testosterone, desiccated thyroid, growth hormone or growth hormonal peptide, an insulin sensitizer such as a GLP and SGLT2 or even metformin

6:21 or berberine, and then a mitochondrial peptides. And that's kind of how I think about health optimization. The rest from there, that is kind the simple way to think of it and the rest are really going to be gravy, so to speak. There are going be extra add-ons that although could be very, very beneficial, I would say not necessary. Jennifer asks, can you do a deep dive on PCOS for younger women in their late teens and early twenties? It's becoming more common and they need a peptide stack that offers hope. Yeah. So if you look at PCOs, there's actually a push amongst a lot of doctors to rename PCO S a female reproductive metabolic syndrome.

6:55 And we look a PCS, we see this in late teams, early 20s, almost always, not in every case, but almost, always it is a symptom of insulin resistance. We get told it's high testosterone, although hormones do play a part. When we look at PCOS, if you fix the insulin resistance, almost always the PCOs resolves. And so what I would tell someone, whether they're late teens, early 20s, the first intervention could be very simple. It could metformin, and that may solve it. The next intervention can be an SGLT2. Then the third intervention, could a GLP. Some people are hesitant to put teens on GLPs.

7:26 However, in the case of PCO, which can very painful and very frustrating to deal with, I think a microdose of a GLP goes a long way in doing that. So ultimately, The PCOS will go back to metabolic health, and that would be my recommendation to address that. Jennifer also asked, concern peptides help bring up a low white blood cell count. This is a tough one. If you have a low white blood cell count, it could be an immune system thing. So my first thought, and again, this is just as me spit balling, would be to say thiamin-sulfa-1, thymalin, anything to help the immune could potentially

8:02 be good there. And I also too would look at hormones because that could a hormonal thing, although it's much more likely an immunosystem thing so that would my recommendation for low-white blood-cell count at least to get started. I think in that case, It's not going to hurt anything. Stephanie says, is there any science showing no sting reconstitution water impacts GHK-CU effectiveness? Also, what do we know about buccal strip bioavailability compared to injectables? Well, in regards to the sting with GH KCU, if you dilute it down, and if kind of think about it like this, GH-KCU is typically a higher dosed peptide,

8:38 milligram for milligram relative to other peptides. And so most bottles come in a 50 milligram or 100 milligram bottle. Now ask yourself what other peptides come in that size. And so if you dilute down the GHK to where it's much more of a concentration, think about like BPC and TB 500. Typically you're mixing those and you are making a Well, with GHK, we're often doing like 25 or 50 milligrams per milliliter.

9:08 And I think in the best case, sometimes it's like, you know, 17, cause you do three MLs into a 50 milligram bottle. So you have a 17 milligram per millimeter. If we can get that dilution down closer to like that five to 10 range, that's going to greatly reduce the sting. What I would do is get an empty sterile vial. I would mix my GHK. So you have a 50-milligram bottle of GHk, put three mLs in the bottle, take those three MLS out after it's mixed, and put it in a new sterile bottle. Then I'd add two more mls, so now there's five m Ls.

9:38 That's going to be 10 milligrams per milliliter, that's gonna bring that concentration down to something that is more appropriate with the other peptides, and that typically is going to reduce this thing. So if you think about it, almost always you're getting more concentration of GHK based on the nature that it's a higher milligram amount. And if we bring that down, that's kind of in league with other peptides. It's going help reduce the stink. That would be my recommendation for that. Although it is not risk-free still, there's no free lunch, as they say. In some cases, it will still sting, unfortunately.

10:10 Now to the buccal or buckle strip bioavailability, I've used these pretty extensively. I do like them, although I won't say they're all the way there with injections. Anybody that's telling you that, they are just not being honest in my opinion, but I see results from using those. GHK and buckle delivery. And I know it works because my beard gets really dark when I take that. Um, which is a sign of GH K is that it makes hair darker. So it definitely works. I've used CJC in a strip. That definitely it worked.

10:40 It definitely worked something like a BPC to actually heal an injury is going to be hard to get out of a Strip. Again, because it's not going local to the injury site, but I do think they work. My guess would probably be about like 50 to 60% of the benefit of an injection. And so you could either take more or you can just inject. And I'll leave that up to you. Got a few men's health questions. Andrew says, can you do a deep dive on vasectomy impact on men health test levels and peptides or bioregulators recommended before and after the procedure? I personally, hopefully, uh, you never say never, but I do never.

11:13 I never plan on getting vasctomy. And the reason is, um, we want to have kids and then when we're done having kids, I know that being on testosterone without HCG or HMG will basically do the same thing for me. It doesn't make it impossible to get pregnant. Uh, But I would say it's a pretty good chance. My recommendation would be not to get a vasectomy because there are only complications that can come out of it. And I think there's other ways to prevent a pregnancy than to do that. But I understand some people are in a position financially or whatever that they don't want to have that and so my best recommendation after that would

11:44 beyond testosterone therapy, please. Then also too, you could use some of the testes bioregulators just to help restore natural functions. You could do testogen, the injectable one, testolutin, which is the oral one. So that would be my recommendation. Um, but I would probably shy. I know I personally shy away from the second me. Mike says I've been on testosterone in seromerelin and hit a plateau. My doctor is limited in what he'll explore. What would you look at next? I think a GLP would appropriate there. He didn't really say if this was like a muscle or a fat loss issue, I'd say a GLP plus a mitochondrial peptide, SS 31, MOTC could be really good on top

12:21 of that. And obviously I wouldn't move to HDH instead of seromer. Sam says what peptides you recommend for post cycle therapy. So I'm not even a fan of doing post-cycle, meaning that if you're on testosterone, I think you should just be on Testosterone and use HCG or an aclomaphene alongside the testosterone. But let's just say you have a 22 year old bro. They ran some steroids, some testosterone maybe some anabolic. and they want to come off of those and go back to kickstarting their natural production. My stack would be HCG and you could do 500 I use three times per week.

12:52 I would do Enclomaphene 12.5 milligrams every day or every other day, depending on how you feel. Uh, I do injectable glutathione just to help with everything there. Injectable eucarnitine. And then I will give those a shot and see how There's some other stuff you could add in like SS31 would be really beneficial just for whole mitochondrial health in the body. But that would to be my recommendation. You don't have to get too crazy with it when it comes to post-cycle therapy. Some guys will use serums, which I guess clomophene is technically a serum, but they'll use serum or aromatase inhibitors.

13:24 I would shy away from using those because that's kind of common in a bodybuilding world that you'll see. Jack says, can you break down P E G M G F for real world use specifically as a healing peptide? Taylor's mentioned it in shorts, but there's no thorough breakdown out there. Yeah. So, uh, P G MGF comes from the bodybuilding world. It's technically a version that a virgin of a peptides that helps with localized IGF one production. Now, Is it going to turn you into a pro bodybuilder? No. It will actually help with muscle synthesis at the training site if you inject it after a workout, which can be good.

13:57 But I would say for injury purposes, it works really well. And so what I will do is in addition to some BPC, TB, KPV, maybe even some Cardilax, I would inject 250 micrograms to 300 micro grams per day of PEG-MGF as close as you can to the injury site of wherever you're hurting. And what that's going to do, it's not going really do anything for inflammation, but the increase in IGF-1 locally is going have a host of benefits for collagen synthesis and reduction of pain in that area. So I love it. It is definitely one of the most underrated peptides, very affordable and just not enough people know about it, so many people have awareness of BPC and

14:32 TB 500, know about PEG-MGF. So hopefully I'm doing my best to try to tell people about it because it vastly enhances the results that you're getting on top of the BPC and TB500 that might already be using. Let's look at some specific disease states. Jessica says, peptide regimen for hepatitis C. Friend was just diagnosed. I'm wondering my slower whole progression. This would be something I would definitely talk with your doctor with, but I think about hepatite C, anything that's gonna support the immune system would beneficial.

15:05 And I don't know that there's a peptides directly that will heal it. Although I'd say thiamin-sulfur-1 would absolutely be beneficial, I would think LO37 could be beneficial. I don't think that that would hurt. Thymalin could very beneficial, I think KPV to help bring down some of the inflammation would be a beneficial as well. So that's kind of where I'd start and that is unfortunate. Are there peptides that help with high blood pressure? Ask David. Yes, there absolutely are. I would say the GLPs are probably like the easiest go-to first. So GLP's, by the nature of improving metabolic health, are going to help bring down blood pressure.

15:38 But there's actually a peptide I've used for a little bit and I really like called B733, and that's an anti-fibrotic peptides, but also what it does is help down pressure down. Now, I don't have high blood pressures, so my blood pressured didn't really change. It's not going induce a state of low blood Blood pressure like a telmasartan would, or like, a low-sartin would. But B733, and you could do like 300 micrograms to 500 micro grams per day of B 733. It is out there. Research companies have it.

16:08 And so that would be my recommendation directly for blood pressure. Obviously, it goes back to metabolic health. A GOP would good. There's another peptide called Vessagen that helps with blood vessels. That's just going to help with endothelial health, that'd be good, You can look at some Cialis, so Lodo Cialsis like 2.5 milligrams to 5 milligrams per day would be helpful as well. Chad asks, I'm interested in myelin regeneration and protection, specifically as it pertains to MS. This can be a tough one. I don't know that there's any peptide specifically, although I have seen some papers of people working on peptides to help with myelin regeneration.

16:42 My go-to would be ARE290, potentially cerebral liacin for the MS, BPC157, TB500. Again, Vessagen could do really well in that instance. And then also, I'm thinking anything else in addition to those, you know, myelin regeneration can be tough. Potentially something like a cartilax could help. I wouldn't say that would directly help, but especially if the person with MS is dealing with weakness or pain, that could be beneficial too.

17:15 Let's see. Filippa says, I was diagnosed with F and D months after an ischemic stroke, likely V related clot. Despite a healthy lifestyle, what peptides might help? I've actually made a V-related peptide stack and just rattle those off for you. SS31, thiaminosalpha-1, KPV are going to be the primary players that I would use in that. You know, you could use a microdose of a GLP to help with that and reduce clotting risk as well.

17:45 But that would be my recommendation. And a lot of times that's the body having this reaction. I don't think Vessagen would a bad idea either. So Vesagen at one to two milligrams a day could be beneficial in that case. Chris says, my 48 year old wife had a kidney transplant 16 months ago from a rare autoimmune disease. She's on anti-rejection meds, steroids, statins, and antivirals. I'm on Reddit and Clo for information. What peptides might be worth exploring for her? This is a tough one because if you have a Kidney transplant, you basically don't want the body to reject it.

18:17 And so they're, it's kind of tough to add in peptides on top of that, because you don't know how it's going to react to all these medications. It would really, in a lot of cases, be necessary to make sure that her body doesn't reject it. I think something very basic, like a microdose of a GLP, is going alleviate some of the metabolic burden on the body, which could be beneficial. But don t take that as an official recommendation. Also something with the immune system, potentially thymus and alpha-1 could also be good because, again, you want to modulate immune activity.

18:50 to which the body's not going to reject that. But again, that's something that you would look at secondarily to whatever your doctor is recommending. Jose asks, what's your opinion on dihexa for Alzheimer's protocols and stacks? I think di hexa works great for alzheimer's. I would obviously lean into cerebral lyosin first and you can go to cerebrallyosine.com and just click on the practitioner page and they have dosing instructions for people that are administering cerebral lysine for things like stroke or Alzheimer. But dihexa can be great.

19:20 I think for the case of Alzheimer's, 10 milligrams is usually the daily dose of diHEXA. And so you could probably take someone to like 20 to 25 milligrams of DiHExA per day and they would do pretty well there. But I really like it for Alzheimer. It's one of those things you can definitely use. In my opinion, only going to be benefit for someone like that. Can you do deep dives on urolithin A and P21? I've got my six or 87 year old mother on Urolathin-A and p21 for neurodegenerative issues and would love your take. I think that's a great thing to do. Would probably also add in cerebral liason again, like I mentioned, and then also with someone that is in their eighties,

19:56 I thing something like SS31 I seem to really, really well and people like that. And I would say if you could go up to like five to 10 milligrams per day of SS 31, you're probably going to notice a big difference. Uh, like we just talked about, dihexa could be another really big one there. I think Urolithin A is great. Um, forgive me if I'm misquoting this, but it is a mitochondrial antioxidant. So we do see a lot of benefits for the mitochondria from Uralithine A. so I love that. And I take it as well. Does the non-Admentane version of P21 work as well as the Admentain version?

20:29 Can you cover P-21 dosing and what to expect? I'm going back to school in my 30s and looking for cognitive support. I don't know specifically about the ADmentaine version. Dosing wise, I like 250 micrograms, three to four times per week. That really does well for me. And I think you could take it higher if you need extra cognitive supports. You could also combine it maybe with like a Dadei Hexa or a NeuPept. So you can probably go as high as like 500 micro grams to one milligram. But for me, that would just be too strong. And so you kind of have to evaluate your workload, evaluate you're unique neurochemistry, and then also too, if you wanted to stack it with one of those

21:01 other ones that's going to help with memory retention and learning, I think you'd do really well for that too. But I do have a video on my channel about P21. If you want the deep dive on it, you can check that out. Let's talk about a couple GLPs. So GOP's case says I'm running 3.5 milligrams of TURS three times a week, plus one milligram of RETTA three time a day. When calculating the 15 milligram Turs weekly max, do I include the Retta in that math or is it separate?

21:31 I personally look at it as together. And so I look if I am stacking Tours and Rettas together, which I know people do, there's debates on whether you should do that or not. I think in a perfect world you would just use one, but some people like the appetite suppression from Ters that they don't get with Reta in lot of cases. when I'm looking at my total GLP load per week, I would combine those. So this person would basically be on 10.5 milligrams of TERS and three milligrams are red out, which would be 13 and a half milligrams.

22:01 And so I wouldn't say that is my totally weekly dose. I will not keep them separate. Just for the purposes of titrating up and down, that's what I look at is the total weekly does dose of both of those combined and where I, where would go from there. Carrie says, do you still believe metformin is the best for longevity? I would not say it's the, best, however, I do think it is important. I actually just wrote an email on this the other day. Maybe I should even turn that email into a video because it was all about the new studies that keep coming out about how beneficial met formin and is, and I think a lot of this comes in the dosing.

22:33 And so like 500 milligrams of met for men per day versus 2000 milligrams on that form in per. You probably are getting into. A terrain where there's going to be. less benefit at a higher dose and more side effects. But I still love it. To me, the holy grail of insulin sensitivity with longevity would be a GLP like a TERS or a Reta with an SGLT2 like Jardience or Farcega, which Farsega is now generic. So you can hopefully get that a lot cheaper. Your doctor will write a prescription for it and then metformin at 500 milligrams per day. And so that would my recommendation. Yes, I'll still take 500mg of met formin.

23:05 I know there's people that hate it, but I do really well on it it seems to help me and so I keep it in. Let's talk about some performance and mitochondrial stuff. Lauren says, are there people who don't respond to MOTC? I ran a cycle at two milligrams, five on two off and felt nothing. I've heard people with healthy mitochondria may not respond. There definitely are non-responders to everything. And so I would say if you're taking two kilograms and it's not working at all, um one that kind of stinks but then also two there are higher dosing options so if you're not responding at all you could potentially go up to four milligrams or five milligrams and see how you do i know people that do that but

23:39 i personally like i could never do, that i took some matzi with some five amino the other day literally just one milligram of both and i was so jacked up that I like felt i felt like I was on speed like it was crazy And that's just not for me to go up in dose to MOTC. And I would say I'm pretty healthy from a mitochondria standpoint, at least that I know of. I haven't done the mitochondrial efficiency test. There's one that is out there now. But I'd say some people are definitely non-responders.

24:10 You can try going up with a dose. Be careful because some have an anaphylactic shock reaction or a histamine reaction at the higher doses. So just be careful and go very low and very slow. But I don't think it's the end of the world if you don' t respond to MOTC. There's other mitochondrial peptides out there, obviously like SS31, and you can use something like a 5-amino to get a lot of same effect that you would get from MotC Lauren also says, I'm on 90 milligrams of armor thyroid. Do you time L carnitine around your thyroid med to avoid interference? Also I've heard glutathione can cause premature graying.

24:40 Is there a dosing threshold to that? This is one of the myths about carnotine and thyroid that the carnatine will block the effectiveness of your thyroids. This was vastly misinterpreted according to the data. And I don't have the study right in front of me, but I have. Read about this some and basically I think the thought is that the L carnitine blunts the effectiveness of the thyroid medication. I still take them together and have no issue with my thyroid working properly. My thyroid and medication working working properly.

25:11 And I think for the doses that you would have to go to the L-carnitine to basically like negate it, it would just be impossible to take those doses, that would end up suppressing it. So that's my opinion. But there is, there's like mechanistic data, but in practice, we don't see it and then in terms of glutathione, I don t know that there s a minimum threshold dose. I do know, when I inject glutothione I get more grease in my beard for sure. And so is there a threshold holes? Maybe. But I think the threshold dose, if there was one, you probably wouldn't get the benefit.

25:41 And, so I know it sucks, but my alternative would be, hey, maybe we can throw in some GHKCU to help with the graying and that's going to kind of offset. In my case, that does offset the greying from the glutathione. Chris says, I had great results on 250 micrograms of SLU. I tried 25 milligram pills with Matzi and had one amazing workout, but haven't been able to replicate it since. Should I go to 50 milligrams or is this diminishing returns? My opinion, the higher dose of Sloop is diminishes returns. There's different thoughts on this and that's totally okay if someone wants to take higher doses.

26:11 Um, i personally only had bad results after initial good results, after like a week or so. The high dose SLU just did not work well and I ended up feeling bad. I've talked to several people out there that also had the same issue. And so I would just go back down to the low dose. Even if you don't necessarily feel it, there's still going to be basically genomic changes that are taking place that're going be beneficial at the load dose, you're just not going get like that overwhelming feeling But I think there's other things you can use to use that or to get that feeling,

26:43 obviously. So that would be my recommendation. But, I mean, hey, to each their own. James says, how much BAM-15 and SLU should someone take and how do you cycle them? Also, How long do peptides last refrigerated? For the BEM and S.L.U. I like doing 50 milligrams of BAM to every 250 micrograms of SLU. There's a huge debate online of whether you should take them or not. I'm not here to tell you to do either one.I have used them together and I will say it worked for me. So again, whatever the theoretical implications are, we just haven't studied it in humans.

27:15 And so really it's just kind of anecdotal that we're going off of right now, which I know is not ideal. But if I were to them, I would do 250 mcg of slu to 50 mg of bam. And then I would scale it up. So like for 100 milligrams of BAM, I will do 500 micrograms. That's all you. And I think if you're there, that's going to be like a really good place for most people. But I know there's people that don't agree with doing those together and hey, That is totally fine. I'm not here to tell you what is right or wrong. And then peptides last refrigerated.

27:45 Most of them are good, like four to six months refrigerate. Obviously there's probably a little degradation there. I've injected peptide personally. There were two years in the fridge mixed, meaning they weren't, they were not lyophilized. They were mixed with backwater after two and they still work. And so sure there was some degradation, but in terms of being completely inert, Even after a couple years, there's probably still some potency there. But I would just say within four to six months is usually going to be the best. Obviously within 30 days is like the highest and then there is some degradation after that.

28:15 And so just understand that in also to every peptide is going be different. Let's talk about some growth hormone peptides. So Larry says, what is the optimal testosterone dose for a non-HIV person? The two milligram recommendation comes from HIV related visceral fat studies. Is it better stack with hypermellon and does it really need room at temp storage? Well, first, I'll say a lot of people start with one milligram of Tessmerolin, and that works really well for them. I like one milligrams. Two milligrams I get more bloating when I'm at two milligrams, so one kilogram is kind of the sweet spot for me.

28:48 So I do one miligram. For some women, they could even do 500 micrograms and get really good results, because women typically get bloated even more so than men when it comes to Tissmerolins. That would be my recommendation for the starting dose. And then if you don't get the results you want, you can go up to two mg and see how it works for you. Is it better stacked with Ipamerelin? It definitely can be stacked. I will say that is the strongest combination of growth hormone peptides. So Tessamerelin with ipameralin, and I like to do them in like a three to one ratio.

29:18 And so if I were going to those, I would do like 600 micrograms of Tessemereline with 200 micro grams of ipumeraline. It is really going to work. You will definitely feel much more fuller and vascular. But some people like myself tend to get a little bloated. And so just be aware of that, but you definitely can use them. Tessamerelin being the GHRH and ipamerelin being GHRP. They work synergistically to increase growth hormone through different pathways. Um, and so if you're going to stack two together, you could do Tessa and Ipa or CJC and IPA. I would not do test it and CJ C together.

29:50 Or some people even say test the CJ and APA, I wouldn't take all three of those together Does it need room temp storage? I will tell you this, I have always kept my testosterone in the fridge and it always did fine. It never gelled. And so that's all I can say. I don't have a study to tell which one to do. If you want to keep yours at room temperature, by all means, leave it out at a room. Honestly, most peptides at temperature are probably fine for longer than we think they are, but it's obviously safer to have them in a fridge. When it comes to stuff like this, I really don't get into the, the squabbling over, you know, as your testosterone should be in the room temp,

30:27 be it room temperature or in a fridge. There was obviously with pharmaceutical grade testosterone recommendations to use it with sterile water and then use immediately. And then also too, they said to keep it at room but in practice I have always kept mine in the fridge and it always worked. How do I know it worked? Because three weeks after using it, I'm looking at myself and I look super pumped, but I also have water retention. So obviously it's working after being in a fridge for three week and using five days on, two days off. Susan says, can you cover MK six seven seven more in depth?

30:58 I'm interested in using it during a break from CJC and IPA. Sure. I think for dosing for MK 677, I would do for a woman, uh, 10 milligrams per day. A lot of guys will do 25 milligrams a day I actually more of a fan of MK 777 and I was started 10 grams per of that. But basically either of those is a small molecule GHRP. So it's, technically a small molecule, but it works very similar to how like an Ipomerelin works because it's a ghrelin agonist. And by doing that is going to stimulate ghrelin, which is then going increase growth hormone, Which is, then gonna give us those benefits.

31:33 The problem with MK 677 is that a lot of times it causes water retention and a raise in prolactin and cortisol, as well as blood sugar issues. 777. I have not seen that to be an issue. So that would be my recommendation for that, but yeah, you can absolutely use that in an off break from CJC and IPA and go right back and forth between that. That's a, that's the good thing about the growth hormone class is that we have enough to go back in forth that you could really use one all year, or you Alma says, what explains anaphylactic reactions to seramarylin or other GHRHs and GHRPs that appear after a year of use?

32:11 Can that person ever use GH secreted gauze again? Honestly, I don't know. It's interesting. I've talked to several people that can be using a GHP or GH RH. And then one day after year or a half of years, they just get this terrible allergic reaction. Some people end up going to the hospital and they're obviously scared to use it again because they don' want to have the same thing happen. Again, and so honestly, I don't know. I think to that, the answer would be just use growth hormone because that's bioidentical in almost zero cases. Are you going to have that?

32:41 But it's obviously the immune system is having some sort of response to it. And whether it is the peptide itself, whether its the purity, my inclination is to, because I really think most times purity is overblamed for causing some of these reactions. And I think in a lot of those cases to what we were just talking about with the MK 777, I've seen very, very few people because it's a small molecule have that reaction. And so that could be something for them if they're not willing to.

33:12 use growth hormone. But yeah, it definitely can happen. And I've seen it with everyone. I have seen, or not everyone, but every of those peptides, seramarylin, tessemaryl, and CJC. Seramorylin seems to be the least causing of that. Obviously that's a GHRP, which would make sense. So I think the GHRPs less have that less, But still, you know, have you seen that? I haven't seen. Jared says, can you cover GHK and HK for hair loss and gray hair reversal plus skin care application, sub-Q creams and serums?

33:44 I would say specifically for a hair-loss, you're going to want to micro needle those in. You could do a combo of GH and AHK. AHk is a version of ghk that is more specific to hair lost. And so you could get a micro-needle and roll that in on the scalp on areas you want I haven't personally done that, but obviously you can look at me. I don't have any issues with hair. If anything, I have too much hair and so I know that's a problem. A lot of people wish to have, But hey, we have a lot hair, you also get a lotta hair on your chest and back. So it's something that is, it can be a blessing and a curse at the same time.

34:14 But that how I would do it. Obviously serums can great too. You wanna make a GHK or AHK serum, You could do that. Subcute is not gonna hurt. so you could layer that on top and then the creams you Could also use as well. The serum's are probably more effective for hair loss specifically. All right, we're getting close to the end. Let's talk about some stacking protocols. Karan says are there guidelines for introducing and stacking peptides or is it symptom based selection? Certain peptide may be ineffective with copper and zinc imbalance or hemochromatosis until signaling molecules are addressed first.

34:47 I really wouldn't worry about the copper and zinc imbalance. Maybe if you're talking about like mixing GHK and glutathione in the same syringe, you could run into an issue with that. But in terms of stacking, I want people to think about it as hierarchy based, meaning that whatever your issue is, address that issue in a window of time, whether that's three months, six months 12 months two years. and use your peptides accordingly to fix whatever it is that you are dealing with during that time. A lot of people just, I've talked to so many people that go buy 20 different peptide, 20 peptids.

35:20 And then they come and they're like, do with these, tell me what to do. It's like well, first of all, what is your goals? And if you don't understand what your goal are, you can never actually achieve them. And so for your health, it's losing weight or improving neurodegenerative disease or improve your immune system. Once you know that, then you can start to build it. And I think in most cases, there's like five to seven peptides in almost all cases that are going to work really in serving that goal to which then, you will hopefully heal that and get to where you want to go.

35:51 So that would be my recommendation. Obviously, I can't tell everyone that in one question, but that's how I would do it, Danny says SLU PP332 pills or injection, which is better. I've used lyophilized SLUs and to me it worked the exact same as the pills. And so I would say the Pills. The one thing I have not tried is SLUPP333 suspended in oil. and from what I heard from chemists, that seems to be the most effective way to dose it. Although I haven't tried that. So that's something if I can find it, maybe I'll report back and tell you that it's better, but for right now pills seem to the best way.

36:27 Jason says, what's your best practice for reconstituting ARA290? I've seen phosphate buffered saline used with success. I'm hoping to help my father with chronic neuropathy. You can do PBS. If you want to use backwater, I have used back water for A RA2 90 and it worked for me, but some people get it gelled. And in that case, you could use phosphate, buffored salene to mix instead of the back-water. It usually does really well and I helped people with that and reported back that it works well. And so you would just use the same amount of PBS as you, would the water. I would try to make sure that you're using a little bit faster than you use backwater because to my knowledge, it doesn't have the exact same preservative

37:04 profile as back water, but you'll still be okay if it's like a few days or two. Just moving along to the ones I can actually answer. I Can't answer anything about sourcing on public platforms. Sorry. You gotta be in the private groups or the email list for that. Um, Bart says could TA one trigger a negative immune response. My recent lab should CRP jumped to 3.2 and positive ANA. A I ran a heavy TA1 protocol, 1.5 milligrams a day for five days, about a week before testing.

37:34 It would be rare, very rare that it does. Although I think in some cases, if your immune system is suppressed, TA1 can kind of kickstart some of the processes that are taking place that would then lead to, okay, like maybe the body is in a state of inflammation. So I would say it's very rare, but to me that seems more coincidental than it seems causal from the TA-1. Now, specifically for the CRP, I've seen SS31 actually work better to bring down CRPs than thymus and alpha one.

38:06 Although I don't think in most cases, most people are going to experience that with the, the CRP going up on thimus alpha 1. But I would say SS 31 in my experience has been the biggest needle mover to bringing CRRP down. I think a GLP microdose and glutathione are also going work in service of that goal, but that would be my recommendation. That is interesting that, um, a TA-1 protocol would have caused that. So let's see. And I think that is it.

38:37 I did get a question on a protocol document covering yearly bioregulator cycling. That's something that I'm working on. Can't obviously answer that in one question, but it would be a really good thing to know. It's one of those things that the best Russian literature is often misinterpreted. and I am hesitant to put something out around that that would end up being wrong. I think the bioregulators, obviously the injectable ones work great for specific things. For instance, if you have lung issues, bronchogen and conlutin work really well together.

39:07 If you an issue obviously with an injury, cartilax works really if have an issues with your immune system. Velon can work well. supposed to be pronounced thymalin again with your immune system, obviously epitalon with anti-aging and sleep can work really well. So those all have really good interventions, but I'm still hesitant to put out anything definitive because I've just seen different protocols out there. At the end of the day, I think the best way to use those is a targeted approach.

39:37 If you have a specific issue and then like assuming you're perfectly healthy and everything's good, then you can look into potentially building a stack I don't think you would necessarily harm yourself by mixing the wrong ones, but it just might not be the smartest thing to do. And you might be wasting money if there's a better alternative. Like for instance, if you said, okay, we're going to pair epitalon, pinealon and thymalin together, which I've seen at least from a literature standpoint do really well versus mixing in velon with that. Then eventually maybe it's like not the best thing. So that's my thoughts on that, but I would love to do that.

40:09 I just want to talk to some more people and see some data around what would be best before I start making stuff up. Because one thing I'm hesitant to is just go out and make stuff. Obviously, even you can hear in my Q&A, I try to be the best about telling you if I don't know something and being very transparent about that I. Don't want you guys to think I have all the answers by any means I can tell you what I've experienced myself and what i've seen working with other people. and what I've read and researched, but I'm not going to sit here and tell you things that I don't know about just to give you an answer or just make things up or tell things just satisfy the craving and then make you think that i'm some guru that knows everything because that is definitely not the case.

40:46 If there's anything I know each day that get up is that there is so much that don t know and so more to learn and I always want to be transparent with that. But that's it for the questions today. Thank you guys so much for submitting those questions just in closing. If you have a chance and you question, submit them down in that question box, which will be in the link of the description of all of these. It goes so far in helping me build this content to better serve you. And without you, guys, I don't exist. So just closing, have so gratitude for everyone out there, whether it's being on the email list, in my private group, sharing this with the friends and family,

41:17 using my code at places, leaving a comment, liking any of those things that you do go so far and helping me bring these messages to you. And at the end of the day, I always tell people I want people to be able to take my content and go out and act on it in the world so that don't have to pin on me. You can learn what you need to learn and Go forth with your life. So whatever it is that You do to support me, thank you so much for doing that. Without any other thing, we'll wrap it up and I will see you in The next one. Peace.