Reader Mailbag 3 — Traveling, Glutathione, Sleep & More | Hunter & Taylor Williams
Taylor and I sat down for another round of reader questions. These mailbags are where we slow down and actually unpack the stuff people ask us over and over. Some of these are new. Some are oldies but goodies. All of them deserve more than a rapid-fire answer.
Here's what we covered.
Traveling With Peptides (And TRT)
Travel season is here, so this one came up twice. People want to know how to actually fly with peptides, where to put them, and whether to even bother bringing them.
Our protocol is simple. Everything goes in the checked bag. Peptides, needles, vials, all of it. We use a cheap insulin cooler from Amazon with frozen ice packs. I preload pens the morning of the flight so we have them ready when we land. Usually that's growth hormone, a GLP, Melanotan-1 if we're going somewhere sunny, and Thymosin Alpha-1 or LL-37 for immune support. KPV is huge for travel because eating out wrecks your gut, and KPV helps with that.
We've flown with this setup to Europe and Mexico. Never had a real issue. They searched our checked bag in Mexico once and didn't care about the peptides at all. They cared more about a tin of mouth tape that looked like tobacco. In Europe, they don't even search checked bags through customs.
For TRT, just bring the vial and syringes. Don't preload. Taylor and I learned this one the hard way. We preloaded testosterone in Europe and the pressure change blew it all out of the syringes inside the bag. Lost the entire trip's supply. Bring the vial, draw at the hotel.
Taylor's take: if you're traveling for more than three or four days, you're checking a bag anyway. Just put everything in there and stop stressing about it.
And if you can't bring them at all, you'll be fine. Two weeks off peptides is not the end of the world. Sometimes it's actually nice to ease up on the GLP and enjoy the food. Just tighten back up when you get home.
Why Glutathione Stings (And What Actually Helps)
Two people wrote in about the same thing. Glutathione hurts to inject. One woman in her 50s gave up and went sublingual. Another is using buffered glutathione from a compounding pharmacy and still gets pain.
Here's the thing. The pain is not a mast cell reaction. It's not an allergy. It's just the nature of glutathione as a molecule. L-carnitine does the same thing. My best guess is it has to do with molecule size, but chemically I don't fully know why glutathione hurts more than other peptides.
What does help:
Taurine bacteriostatic water is the single biggest fix. There's a vendor that sells it. Reconstitute your glutathione with taurine bac water and it makes a real difference. Bonus: taurine enhances absorption too.
Use a 27 gauge needle, not a 29 or 30. Counterintuitive, but glutathione is thick and viscous. A bigger gauge lets it push through easier with less force, which means less tissue trauma.
Dilute it down further. If you have a 500mg vial and you usually do 5ml of bac water for 100mg/ml, try 10ml for 50mg/ml. Less viscous, less painful.
Let the syringe sit on the counter for 30 to 60 minutes after you load it. Seems to loosen things up.
Roll the injection site afterward. A lacrosse ball, a foam roller, a massage gun. Taylor's mom has one of those automatic roller machines at her red light studio and that thing is amazing for post-injection soreness.
Map your glute injection sites. Some spots are way more tender than others.
Sub-Q glutathione is not great unless you're doing tiny volumes, like 10 units for a daily microdose. Anything bigger and you'll get a knot.
Even with all of that, you'll still get one or two painful shots out of ten. That's just the deal with glutathione. Sublingual and liposomal versions exist, but I've never found one that actually works.
Melanotan-1 vs Melanotan-2 (and Skin Cancer)
A few people asked about Melanotan and skin cancer history. Big question.
Quick breakdown. Melanotan-1 is my go-to. It gives a golden, natural-looking tan. Fewer side effects. FDA-approved, actually studied in clinical trials. I think of it like sunscreen. In the summer I do 250mcg two or three times a week and I don't burn.
Melanotan-2 is the tanning bed version. Faster, stronger, but it darkens moles, creates an orange undertone, and brings nausea similar to PT-141. If you're really pale, Melanotan-1 might not do much and Melanotan-2 will at least move the needle. Use it for a specific event. Photo shoot, beach trip, whatever. Don't run it year-round.
For anyone with a history of skin cancer or family history, Melanotan-2 is off the table for me. Stay away from it. Melanotan-1 I think is actually fine and possibly protective. The cascade with melanoma usually starts with burning, and Melanotan-1 prevents the burn. No burn, no inflammation cascade. That said, this is individual discretion. If you're worried, talk to your provider.
One thing nobody talks about with Melanotan-1: there's a cognitive lift. You feel better in the sun. It's like digestive enzymes for sunlight. You get more out of ten minutes of sun than you would otherwise.
Severe Female Insomnia and Perimenopause
This is Taylor's wheelhouse. We get this question constantly. The reader is a perimenopausal woman who was using MK-677, slept great, but started binge eating and got worried about insulin resistance. She doesn't tolerate CJC or Ipamorelin because of histamine reactions. Is DSIP and Selank the answer?
First, there is no peptide version of Ambien. Nothing is going to knock you out like that. And honestly, the way people still use Ambien is wild. I've watched coworkers drive 45 minutes to work with zero memory of the drive.
Taylor's take on this one: stop MK-677 and try MK-777 instead. Less hunger, less binge eating, same sleep benefit.
But the real foundation is hormones. For a perimenopausal woman, sleep is downstream of progesterone, estradiol, and testosterone. Progesterone alone fixes 80 to 90 percent of these cases. A lot of providers now dose progesterone specifically based on how the patient is sleeping. Some women need 100mg, some need 800mg. If you're on 100mg and still not sleeping, talk to your provider about going up.
Then layer in low-dose naltrexone if there's any inflammation component. LDN can help with sleep more than people think.
DSIP is useful, but here's the nuance. DSIP doesn't help you fall asleep. It keeps you in deep sleep longer. So if your problem is staying asleep, great. If your problem is falling asleep with racing thoughts, you need something else.
For mind chatter, Taylor tells every woman to keep liquid L-theanine on the nightstand. Wake up at 2am with the brain spinning? Couple of drops, back to sleep.
Other stuff that works: oral epitalon (3mg capsule is roughly equivalent to 1mg injectable), nasal melatonin, transdermal melatonin, MK-777, growth hormone peptides, actual growth hormone if your provider will write for it. VIP is great if you're a shift worker because it resets circadian rhythm at the hypothalamus.
Minerals matter more than people realize, especially for women. Taurine and magnesium are the foundation. If you're adding HRT on top of an already mineral-depleted body, you'll feel worse before you feel better.
And the boring answer that nobody wants to hear: sunlight. An hour or two of actual sunlight, watching the sunrise, watching the sunset. Most perimenopausal women I talk to are up at 4 or 5am, working under fluorescent lights all day, then sleeping next to a smart meter with their phone in the room. Until you fix the light environment, no peptide is going to fully save you. If you have to be up before sunrise, wear blue light blockers. You're telling your body to be awake when it should be asleep.
Retatrutide Plateaus and GLP-1 Desensitization
Three different readers wrote in about Reta not working anymore. One titrated to 1.75mg and lost appetite suppression after two weeks. One has more hunger and isn't losing weight. One switched from semaglutide to Reta at 2mg and feels nothing despite needing to lose 100 pounds.
First, an important distinction. Appetite suppression and food noise reduction are not the same thing. Semaglutide and tirzepatide knock down both. Reta is different. By week 36 on 8mg of Reta in the trials, appetite suppression was no better than placebo. But the fat loss was massive. So with Reta, the appetite suppression is almost a bug, not a feature. What it's really doing is shifting your energy state. Taylor's dad eats whatever he wants on 2mg of Reta and just keeps losing weight slowly.
You also want to keep an appetite. Your body needs food. Zero appetite is not the goal.
For actual desensitization, look at how long you've been at a given dose. If you've been at 2mg for 8 weeks and you genuinely stopped losing, you have three options:
Go up. Increase the dose.
Come off. Taper down over a few weeks, take 8 to 12 weeks off, then restart.
Stay put. This one is underrated. Most people quit too early. Taylor's dad has been on 2mg of Reta for over a year, never changed the dose, still losing about a pound a week. People expect the dramatic first-eight-weeks results forever and panic when it slows down.
Before you change anything, ask the boring questions. What are your macros? Are you actually tracking? Stop weighing yourself on a home scale and get a DEXA or BodPod. A 145-pound woman at 30% body fat and a 144-pound woman at 16% body fat look completely different. Weight is a terrible metric.
If you need more appetite suppression, you can add cagrilintide or 4-glypron. LDN seems to help with receptor sensitivity in my experience, though there's no formal study on it.
And the big one: hormones. There's a study showing women on BHRT lost 35% more weight on tirzepatide than women not on BHRT. Taylor's mom was on GLPs for a year with okay results. Six months on HRT and her physique has completely changed. Most women on GLPs are not on hormones. They should be.
How to Actually Build a Peptide Stack
Last question. People see a research site with 50 peptides and want to fix everything at once. They either freeze and do nothing, or buy a pile of stuff and get no results.
My approach: find the bleeding neck.
If you saw someone with a bleeding neck on the side of the road, you wouldn't stop to fix their posture. You'd stop the bleed. Same with peptides. What is your single biggest health issue right now? Obesity? Brain injury? Autoimmune? Fertility? That's your bleeding neck.
Pick three peptides to fix that one thing. Just three. Run them for 8 to 12 weeks. Whatever it takes.
Taylor's take on stacking is similar. She works in categories. Main goal first, then layer. For the average person with 30 pounds to lose, some brain fog, and wanting to keep muscle, she starts with a GLP for the weight, adds a growth hormone releasing peptide like Tesamorelin or MK-777 to protect muscle in the deficit, and only adds BPC or TB-500 if there's an actual injury. After four weeks, if energy is still off, that's when SS-31 comes in as a mitochondrial foundation.
Once the bleeding neck is handled, there are five buckets I think everyone should cover:
Testosterone and reproductive hormones.
Thyroid.
Growth hormone (HGH, GH peptide, or MK-777).
Insulin sensitivity (GLP).
Mitochondrial health (SS-31 or similar).
Hit those five and you've covered 90 to 95 percent of what most people need. Everything beyond that is gravy. It's where you get to play, try Dihexa for cognition, mess with new compounds, whatever.
Reta is the closest thing we have right now to a super-peptide that touches multiple buckets at once. One day maybe we'll have a true super-peptide that handles testosterone, growth hormone, thyroid, insulin sensitivity, and mitochondrial health all at once. That would fix almost everyone. ACE-167 in human trials right now might do something interesting for testosterone production by acting directly on the testes instead of through the pituitary. We'll see.
For now, peptides are signaling molecules, not building blocks. They're software, not hardware. You can't write a software program that builds a MacBook out of nothing. Some things, like testosterone, still need the actual hormone.
Closing
Thanks for sending these in. If one person asks it, ten more are thinking it. And if ten people are asking it, ten thousand are thinking it. Keep them coming.
Share these with anyone you think they'd help. In the age of shadow banning, a friend telling a friend goes further than any algorithm ever will.
See you in the next one.
Full transcript click any paragraph to jump video
you Hey everybody, this is Hunter Williams. I hope you're doing amazing wherever you might be in the world today. We have another edition, I think this was the third, one of these we're of a reader mailbag. And what these are, are the questions that you send into me.
But what we are actually going to do is take a longer form Breakdown of some of these that one that we get asked all the time and that two I think Warrant more attention than just our normal Q&A where we're just doing rapid-fire live streams obviously We're doing both But we seem to get good feedback on these and I thing people like them because we can take the questions do a deeper dive breakdown and what's crazy is When I put some of these questions just into a language model to kind of get, it's crazy how much it picks up of the same type of question that I get submitted, which is kind cool because even though
I read through all the questions, I wouldn't have the time to categorize like, okay, these are similar and it can group them together. So that's what we're going to do today. Are you excited? I'm excited. Yes. I think it'd be really cool. And again, some of these are newer ones and then some are good oldies but goodies, as we like to say, that I don't think we haven't talked about in a while, but it'll still be pretty cool to talk about nonetheless. So first one in the spirit of our upcoming travel is about traveling with peptides. We had two listeners write in asking about the practical reality of traveling peptide.
Obviously we're talking about this with airline travel. Obviously, car is pretty easy. You just put your cooler in the car and you're good to go. The first one wanted to know how to plan stack usage around travel. So like, how do we travel, not logistically, but just think about taking peptides with us when we're traveling. Do we just leave them at home or do use them while we are traveling? And then also, too, do you put them in a check bag? Do you them on a carry-on? And how to think about it when you actually can't bring peptides with you so you don't have some people travel and there's not really an option. I think the TRT is a big question, how do bring your needles and stuff with?
So how we travel with peptide and then, also too. How do we not put ourselves at risk? I guess there is always a risk when we talk about. But check back, carry on, customs, all the exciting, lovely things we get to do when travel. What is our protocol for travel? So protocol for traveling, let's cover peptides first. I would say what we have always done is we've always put our peptide into a checked bag.
We've never put it through a carry-on. Now, do I know people that have put them through carry ons and they've had no issues? Yes, but for me, it's just not worth the risk of them going through it, questioning you, and then, one, just having to go through the hassle of being questioned, then possibly having throw all of your stuff away. Like, that's not fun. So for me, I always put them in a check bag. We put in an insulin cooler. Um, we don't have, um, you know, typical insulin coolers, like 15 bucks from Amazon with ice packs.
I know there are some now that are like, They're like rechargeable ones, which we don't have one of those. Put them in the jet bag and we've done this even when we traveled out of the country, whether it's to Europe, Mexico, that's typically what we have always done. Never had any issues with it. And then needles typically go into the checked bag as well. Yeah. My protocol is usually we're flying out in morning, so we'll fly out the morning.
We'll have our Insulin cooler. And what I do is I have the ice packs frozen. I'll put our pins. So we usually use the pins when we travel. Make sure I've some pins preloaded. Sometimes I bring you up backup vials in the insulin cooler backup of like VPC, TB 500 things that I know. Just in case anything goes wrong. If we don't already have those in pins and so I will have usually three or four pins, I ll have my growth hormone pen. Typically if I'm on a GLP, the GL P pen, And then I'm thinking, what else would I usually?
Melanotane one if we're going somewhere warm, sunny. I'll have a pen with that. Thymus and Alpha-1 or LL-37. And I always like having one of those two when we are traveling just to help with the immune system. Yeah. Then I think if you could get a glow or glow blend, obviously, for the sake of travel, that would be easier. BPC, TB 500, GHK, and KPV. Mm-hmm. KPV is huge when you travel just because I get more anti-inflammatory benefit out of that, Yeah, and you also get the gut health protection too, because typically when you're traveling, you are going to not be able to eat your healthy home cooked meals and everything.
You're typically eating out more, eating more processed foods. Yeah. So I'll get all those into the insulin cooler, get the ice packs. I will put all of those in my checked bag. And then when you get to the airport, you just drop it off at the desk and then you're good to go. Now I can give you my places of where I've traveled. They've searched my bag in Mexico, including my check bag, going through customs and never said anything about it. They just looked at it and I guess they assumed it was medication, which it is, and they never say anything.
Ironically, in mexico, they cared more about, I had this tin that looked like it tobacco, but it's actually mouth tape. because I bring my mouth tape to sleep with when I go to bed at night. And they were more interested in what was in that than even my peptide pins. So that's Mexico. Again, it's completely random whether you get searched. That was only one time. Every other time I've been to Mexico, they don't have research. When I'd been in Europe, I never searched the check bags at all. And so you pick up your check bags. I think you actually go through customs before you even pick-up your checked bag.
We do. Yeah. So when we've been to Europe, it was never an issue there. And again, if people ask, I just tell them it's personal medication. Usually, you're not carrying enough stuff where they would think that you are trying to smuggle something. No. I actually brought, the one time that I got pulled aside, Taylor wasn't with me, I was traveling and someone had given me a sample of this salt. And I put that in my carry-on and they thought that because it was salt that they just wanted to test it.
Obviously it just salt, it literally was like a special form of baking salt or eating salt you sprinkle on your food. Was it the Baja salt? No, It was a smoked salt someone gave me as a gift. And I should have put it, I actually didn't have a check bag for that trip. It's pretty good. I forget what the name of it was, but I didn' have that. Uh, didn have it. Check bag. So I would have, put in there, that was like such a quick turnaround. Yeah. But so interestingly, I've never been stopped for that.
Now, a lot of people ask about the carry-on. Can you put your peptides or your TRT in the Carry-On? I never have. And so I have never had an issue. So I don't have an issues with a checked bag. I know a of a people don' want to check a bag for whatever reason. It's just kind of one of those things. If you want be on the safe side to not have to even just get hassled, Yeah. You're probably better off just going ahead and having a check bag. And so that's, it's probably not the answer a lot of people want to hear.
Now I think with TRT, again, I just put needles in my vial. I don't put the testosterone in the pins. Have never been a fan of putting my testosterone depends. No.I just the vile and the needle. you can try to preload syringes, but a of times the pressure will push some of the stuff out of syringe and you'll put, you have them in a bag and then it'll leak out. of the bag because of pressure change. So I just bring my vial with the syringes and then we'll do that when I get there. But I have preloaded the syringes before and a lot of times, depending on how far and how much pressure changes during flight,
it will leak out of the pre-load syringe. And so I think it's better to just bring your vial and then do that. That happened when we were in Europe. We lost all of my testosterone. Yeah. Or you can accidentally take mine when you travel. That happened one time. And she still lives here today. She didn't turn into a man or grow a beard or anything. But I think you just didn' take any for probably like two weeks after that. Mine would have been like a 50 million grand dose.
It was actually probably beneficial because I lost all my testosterone because we did preload syringes and all of it came out. I feel like the only time it hasn't leaked out is when we've traveled just like flown like on the East Coast. Anytime we go even to like Vegas and go West, it still happens. But like Europe, It happened like we lost all of it. Yeah, I think the easy answer is just put everything in your check bag. Whether it's the testosterone, whether it is the peptides. And typically too, if you're traveling, the ice packs stay cold enough from wherever you are going to wherever, you get there and can get to a hotel and
put them in the fridge and then good. Most of the peptides are all going be fine for that. But I've never had any issues at all. I wish I could be that person that brings just a carry on. Well, peptides aside, you're not bringing just carry on. You're going to have too much stuff, so it's not going work out. I wish I was that person. Maybe if I were just going overnight somewhere. If I went overnight, I could definitely do that. There's just so much stuff that I need. Well, especially when we travel with you, usually for like more than three to four days.
Yeah. At that point, it's like, unless you're able to do laundry when you get there, depending on if you. Cosmetics. That's on you so. But yeah, we usually always have a checked bag. And so anyway, We do travel and I've never had any issues. Again, that's with Europe and Mexico and haven't really been to any other places. I think when you travel with the pens too, I feel like those don't trigger probably like scanners and stuff as much too.
It just looks like insulin pens. The needle caps I don' think stand out as muc as actual syringes do. Maybe that makes a difference. Let me just make sure I didn't miss any Oh, well, some people, I think they wanted to know when we travel, do we bring our peptides with us? Obviously the answer is yes. We do. I don't do anything really hardcore, meaning that I'm not going to be like, usually when I am traveling, probably a little bit more relaxed on my diet
and stuff. So I m not gonna be Bringing a bunch of stuff with me like I don't go crazy and then I I Don't really worry about the use as much so like i'm not going to be like super anal about like Taking my like make sure I get my dose of reda like if we're going somewhere and I know like in some cases I think it's maybe not a bad idea to just go off the glp when you travel to Just to enjoy the food know that you're gonna come back and Then get more strict on yourself in your diet, but it's honestly not the worst thing if you don't bring them. Like if I didn't have peptides for two weeks, I would be okay.
If I had to go travel somewhere for 2 weeks and I did have them, that would okay, yeah, might not like be as completely shredded as I might be if have all my peptide and growth hormone and everything. But it is not at the end of the world. I do typically bring it. And if don''t bring, you'll be ok. Next one is about glutathione. The glutathione pain problem, why it stings, and what we would actually do. So we got two people actually asked about having issues with pain and glutothione. One was a woman in her 50s.
She could not do the injection, so she went to sublingual, which obviously she knows is not as efficacious. Second, has buffered glutithione from compounding pharmacies, but she still gets pain. The question for us is, what do we do? Why does glutthione hurt this much in the first place? And what's actually happening at the injections site? It's not a mass cell reaction. So a lot of people think that that's it, as it would be with like GHK or a GH peptide or something like that. It is actually not, it's just the nature of glutathione.
Chemically speaking, I don't know really why that one stinks so much more, other than the fact that maybe it has something to do with the size of the molecule. Glutathion's a different size than most peptides, like L-carnitine, which also stings. And so it could have something do do that, And they want to know, like, basically, is there any alternative whatsoever to have injectable glutathione where it's not going to hurt? Alternative? Like, I mean, if you can get taurine backwater, that's been the only thing I've been able to find to help with relieving that pain is having tauring in
the back water when you go to reconstitute your glutothione. is after you load your syringe, letting it sit out on the counter for about 30 to 60 minutes, I feel like it does help kind of loosen it a little bit. But that's been the only thing I've been able to really find. I think using some type of roller afterwards, that helps, too, to roll after your inject, as much as it's not fun because it is sore.
You know, another thing also you could try is, again, not fun, but maybe use a bigger gauge needle, a larger gauge. Maybe that will help. Yeah. One, I think if you were going to do it, like you said, the taurine backwater, we're not going talk about vendors, there is a vendor that sells taurean bacteriostatic water. That does seem to help, and that's what I always use when I mix my glutathione. And it does make a difference compared to either premixed or if I was mixing it myself. If I was just doing it, because some glutathione comes mixed, depending on the vendor, you can get it mixed already.
And then some comes lyophilized and you would mix it yourself. So I prefer to get the lyphilize and mix myself with the taurine back to your static water. The taurean also enhances the absorption of the glutothione too. That's a good benefit. Like you said, obviously, rotating injection sites help. Actually, I've had less pain with a 27 gauge needle than a 29 or a 30 gauge because, again, with it being thicker and more viscous, it pushes through the bigger needle a little bit easier than the smaller one.
I would not recommend you do sub-q glutathione injections unless you're doing a very tiny amount volume-wise, like 10 units. And the amount could depend depending on how you mix it. But you could do like a small amount, like 10 units. Like if you're a microdosing glutathione daily, that could also be something too. If you wanted to do it, you can just take a smaller dose every day. Yeah. if You wanted do a sub cue, You typically won't get like, a knot like you would if were doing a larger dose that has a large volume of injection. So if wanted you to that, and I think that would be fine.
I don't see any issues with that. But if try to anything more than like 40 units sub-q, you're going to have problems. You're gonna get a nodule. Like Taylor said, I would massage the area with a lacrosse ball, a foam roller or something like that after the injection, but it's kind of one of those things. It's still hurt sometimes. Now I will say doing what I do it probably helps about like 80 to 90% of the time.
Sometimes you'll still have like one or two out of 10 shots that you're just not going to feel great on. But if I, at least within those few minutes, can get the massage gun or massage ball, roll it out, that does help break it up. And then I usually don't have issues after that. Also too, my mom at her red light bed studio has this rolling machine. And these things are awesome. If you can find one, they're a few thousand dollars. But if you find a place that has one is like this automatic roller that you get on.
And that I will say for post-injection pain, whether it's glutathione or whatever it is, has been really good to do, to at least get like two times a week that we can get to that studio and use that. But I would say also make sure you're mapping out where you actually injecting. Cause I think, especially with glutathione, you want to inject that into, I mean, glutes is like the best place because it is a larger injection, but really making sure your mapping where your putting it at in your gluts, because some areas are going to be more tender than others.
And if you don't know those spots, like that can make a difference. Yeah. Also say one thing I forgot too is the injection dilution amount. Let's say we have a 500 milligram bottle of glutathione. If you put five mls of water into that, it's not going to be 100 milligrams per milliliter, which is usually what I do. But sometimes if you dilute it down even further to like 50 milligrams for milliliters. So in that case, you, what would that be? You would add 10 mls of water into it to make it 50 milligrams per milliliter.
It's the same way that you would dilute GHK with more backwater. If you dilue the glutathione with back water, that will probably help too. We'll make a less viscous and more watery and liquid rather than being so thick. And so I think that could be beneficial too, but yeah, it's one of those things two to three times a week. The first time I ever injected glutatine, I used a 23 gauge one inch needle and that hurt really bad. I won't be going back. But I will say that's like honestly the best thing I know there's sublingual or liposomal glutathione is out there now I've just never found them to work yet.
I hope one day they do but work. Yeah, I have used a transdermal Glutathion, which works pretty good Yeah I would say it's maybe not as as good but I use that before I'd use like a lipozomol So but that it I think we kind of covered that one as much as we needed to. Moving on, this one is going to be, so last reader mailbag, we talked about peptides and cancer risk. We really went into more of like the GH peptide and HGH, but the one today has to do more with skin cancer and melanotan-1 and melanotane-2.
I think for the purposes of just this discussion, We can kind of talk about the differences between melantane 1 and Melanatane 2. what the differences are, which one we prefer to use, and then how that could potentially affect like a melanoma. But we had a couple of people ask about history of skin cancer and using Melanotan 1, Melantan 2. Do they have to worry about that? And so ultimately, how do we think about the melanotam peptides, specifically MT1, MT2? when your son exposed and have skin changes and then with someone that has had skin cancer, maybe they have a family history of skin,
cancer or those off the table for them. And then what about pigmentation and melasma issues with those? Is that something that did those make worse? Do they make it better? And so what would be your thoughts around that conversation? So a lot of questions there. I would say, so to break it down, I'd say as long as there's no active cancer, Melanotin-1, definitely yes.
Personally I prefer Melantin 1 over Melatintin 2. Melatonin tends to have less side effects. Melanotan 2, you can kind of get some negative side effects of like a lot of people will feel more nauseous on it. Similar to how some people feel with like PT-141 with the nausea and feeling sick on Melana Tantoo is going to be in kind in that same boat as that and it will darken moles and hyperpigmentation spots more, um, with Milana tan two and Milano tan to does tend to turn the skin more of a orange undertone,
not saying like straight orange, but you will get more orange under tone. Whereas in like with milana, tan one, you do have more Golden undertone and that golden undertown more golden more yellow is gonna look more natural Yeah, that's kind of my thoughts around Milan tan one and Milan. Tan two is I only use Milan and one I think people can use my answer. Yeah before people have said You never talk about to Milan Tan to you're such a hater.
It doesn't bother me. I just don't I personally don' need it and meaning that Melanotan-2 is stronger and faster. So if you're pale, Melantan 2 will make you more tan than... Melatant-1 doesn't really work for pale people as much. They might just not even get anything out of it, whereas Melaton- 2 is at least going to do something to them. It might not be pretty, but it's going to move them from where they're at. And so that would be my thing. In the summertime, I don't need to use Melanitan 2. I can do Melantan 1 two or three times a week in the summer, and I didn't even have to wear sunscreen,
And I get pretty tan. and i've been starting to do go ahead and do that now just because it getting warmer and everything for summer. So that's my thoughts. But I think Melatant 2 is fine. However, i would proceed with caution from using Melanitan 2 regularly. So if you wanna use it, like let's say- Like the beginning of the season. I think of Melantitan two is like a peptide that is the tanning bed. It's a healthier version of a tanting bed, whereas Melatitan one is almost just more of like, a gradual, Melatan one, is my sunscreen,
and Melaton two, it's like the Tanning Bed. Mm-hmm. And so Melatin two was like okay, I'm gonna be in a photo shoot, or I am going to the beach next week and I do not look good, mm-hm. and then I load up on this to get me there, and have me good for that week, but I'm not going to do that all the time. Yeah. Kind of like you don't do the tanning bed all of the times. Melanie tan one, you can honestly... Or ever. What? Or, ever, I would not go to the tannin bed. We don' t do tanna beds, we don t support tannings. I wouldn't go t the Tanning Bed, But hey, to each their own. You know what's crazy? Tannings beds used to be everywhere.
Oh. In Wakefield next to a movie theater, there should be one there. They're like on every corner that you went, and now, see them that much anymore, probably because of some of the negative health. Although I do think they're still out there. Cause I know they are still there, I think there's still one locally here. Because I was looking for places for spray tans and I recently saw one, but no, taning beds were everywhere. I mean, that's like childhood memories as like riding the car with my mom and sisters to go to the taining bed and this is like,
before like tanning beds like had it where like, they changed the laws where you had to be 18 and older to go in it. And like growing up, you could be any age and going, I remember my mom putting me in and I was like 12 and like coming out burnt. She was just like you just, cause I don't tan very easily. Like I've never really been able to get a dark tan until I started using Melana tan one. Yeah. If I inject Melanatan one that day, I don't have to put sunscreen on depending on where we're at lap, but the next day I have It's there.
So, but I remember like, I mean, you had hanging beds were definitely the thing. You put the stickers on you for the tan lines. Yeah. When it comes to melanomas and stuff, Melanotan 2, based on what I've read, would definitely be a no-go. I would not use Melantan. Even if I had family history, just stay away from it. if that's something you struggle with, or you know people in your family have struggled with. So I would stay away from Melanotan, too, if this is the case. Honestly, I think Melantan-1 is fine, but you have to be the one that uses that discretion.
I don't necessarily see anything that Melatant- 1 is doing that would exacerbate a melanoma or increase the risk of a melanoma. If anything, when you look at skin cancer, in a lot of cases, not all cases. In a What's happening is the person gets burnt and then them burning causes this inflammation that then can create an environment that is favorable to a melanoma. But if you prevent the burning from happening, you don't have that cascade. I think that's where Melanotam-1 could potentially be beneficial.
And it's also FDA approved. So they've looked at this pretty extensively in human clinical trials. It could be been beneficial and protecting against that burning that would then cause an issue. So I think it's actually potentially beneficial, whereas Melanin-Tan II, what it seems to do is kind of exacerbate some of these darker moles and darker skin spots, because you do get that. If you use Melantan-II, you'll get more freckles, more dark skin spot, and so I would think that would be more Melatant-Ii. Again, it is the tanning bed. So you tell someone, hey, use the tannin bed if you need to, but don't do it all the time, or use I don't use it year round,
but you could use a year-round and probably be okay in a low dose. And again, the dose for both of those, I'd say 250 micrograms to start out would be how much you would want to use for a dose, and then you can kind of build up from there. But like if I'm like in Mexico or something, But if I would use one milligram, I just know the nausea is going to be a little bit more. But for me, that would be like, if that was going be outside all day, close to the equator, somewhere where it was gonna be pretty rough,
it would up the dose for that day. And then the rest of the time, just take like in the summer, 250 micrograms, two times or three times a week. I'm usually good and that's enough. All the toxicity that comes from sunscreen, but to the cancer question Again, that's gonna be an individual discretion thing I would definitely like anyone that even worried about that throw melatonin 2 off Use melanin 1 and they would be more as needed and I'd say kind of just on an infrequent basis. Make sure you're cycling No one really talks about Melanotan-1.
I do seem to get much more of, like there is just a slight cognitive benefit when you use Melantan 1. You just seem be in a better mood. Now, whether that's because you're typically in the sun more and you feel better, I think it does enhance whatever benefits you are getting from the Sun. So it's kind of like enhancing the absorption of sunlight. But it is also beneficial for people that don't get sunlight? No, no, it definitely is. Like you get that cognitive benefits even if you aren't able to go outside and get the sunlight Or even if it's just for 10 minutes,
you get more out of those 10 with Melantan than you would without it. And so, yeah, I agree with that. There's benefits beyond the sunlight, but what I meant is that it is enhancing your ability to interact. It's like digestive enzymes for the sun. Digestive enzymes help you absorb protein and fats and carbs better. The Melanitan one I think helps people with Yeah. But that's a Milan 10 one versus Milan ten two. All right. Taylor's favorite topic, severe female insomnia and peri-menopausal sleep issues.
So we get questions all the time. This is definitely one of the biggest issues, what's the peptide stack for sleep? I can't sleep. How do I sleep, is it my hormones? Do I have a peptid deficiency that I need to supplement with peptides? What is going on and I cant sleep and what do i got to do to knock me out? There's a way to preface this. There is no peptide version of Ambien. So there's no Peptide you're going to take that is going knock you out like Ambion. It is wild to me how many people are still using Ambian. Like I just think as like, I have seen people on ambient do crazy, crazy things.
Like people I used to work with would drive 45 minutes to Work and not have any memory of ever driving. It's crazy. Yeah. So this person, this is actually interesting. They've been using, This is a woman. She's been Using MK six, seven, Seven. And she said she got really good benefit for sleep out of it. But now she's binge eating and worried about insulin resistance because she is on MK 6, 7, That's very common. Yeah, that's common with 677. With that. And now she's wondering, she doesn't like CJC or IPA because of the histamine reaction to those, which she didn't get from the AMK.
But should she, really can't sleep and she Chronic female insomnia. She's going through perimenopause. Would DSIP and Solanke help? So we obviously talked to a lot of people like this, going to peri-menopausal, they can't sleep. They have a whole lot hormone issues going on. What would be your recommendation for someone that is struggling with this? Okay, so first of all, I would stop taking the MK 677. I will switch to MK 777 because it does tend to trigger less of that binge eating and that hunger.
So I stop that one and I switch, try MK777. Also the foundation is going to be hormones. Where are we at with hormone replacement therapy? For women, sleep is gonna be such a big one and that's going to depend on where you're at with your testosterone, your estradiol, and progesterone. Progesteron is going help so much with you sleep, even if you are post-menopausal.
Still really important, still really beneficial. That's actually with progeteron being prescribed more so to help with symptom relief. And that would be one of the things, how is your sleep? That something that, you know, your medical provider should be looking at. And that's actually what a lot of medical providers will treat and actually prescribe the dosing amount base for progesterone based on how the patient is sleeping. So that going to be a big one is by identical pro gesterones is going help.
You know, then we can kind of look into like low-dose nitrexone, that can be another really great one, especially if there's inflammatory stuff going on. That also can really help with sleep as well, too. And then, then I would say, let's look into peptides and like, DSEP is going to be beneficial. The MK77, any kind of growth hormone, releasing peptide growth hormones, small molecule, that's gonna also help also just using actual growth hormonal.
There are some medical providers you can get that with and that something that can help a lot too. But the DSEP is going to help, this is one thing I think a lotta people get confused with DCEP, is that DECEP isn't going help you fall asleep, it's just gonna help stay in your deep sleep realm longer. So this is where it's also like, OK, we need to pinpoint down, what kind of sleep issues are we having? Can you not fall asleep? Or is it like you can fall sleep, but you cannot stay asleep.
So if you cant stay sleep I would say DSEP is going to be beneficial because you're actually are having issues falling asleep, But it is just going help you stay in that deep sleep room longer. But if you're somebody, it's like also falling asleep and staying asleep is hard just because of mind chatter. Progesterone is going to help a lot with that because it is gonna help with the nervous system. But what is also going be also beneficial is nervous systems. So let's look at using really great supplements like L-theanine.
that's gonna be really beneficial to help you quiet the mind, quiet that mind chatter. And I always tell women, keep a bottle of liquid L-theanine by your bedside table. If you wake up in the middle of the night at like two o'clock in morning to go to the bathroom, then you have all the different thoughts running through your head that like was just what we do as women. We just get all of different thought at that time that don't make sense. You take a couple drops of that, and it will help calm the nervous system down to where you are able to fall back asleep.
So yeah, that would be my suggestion. I think that um, saline can be beneficial for more so for anxiety. I don't really think it's going to be necessarily beneficial. For sleep. Um, but I mean, again, if anxiety is an issue, I would say, where are we at with progesterone? And maybe you're on pro testosterone and maybe your on like a lower dose of a hundred or 200 milligrams. definitely talk to your provider about going up.
Some women need up to 800 milligrams to really get that relief. And then they really start seeing that difference of their sleep start improving. Yeah. I would say, I think for the question about a woman that's perimenopausal that struggles with sleep, which is how many millions of those are out there right now, it's a very common thing. Progesterone is probably the single easiest answer for like 80 to 90% of them. I think there's probably a contingent of women like 10% that maybe don't do well on progesterone.
But then I wonder how much of that is the Delta, meaning the change from not having any to having some, and they don' have like a one month adjustment period to their body adapting. So much when you talk about hormones, is the issues lie in the Delta, meaning the issue's lie and going from nothing to something in your body having an adaptive phase or an adaptation to that. And then once it adapts, it's actually good. But most people can't make it through a month or two months of that adaption phase, like adaptation phase because it's too much for them,
whether they get bloating, the guys with testosterone, they feel like they have gyno. And then a lot of times it, and then sometimes too, I wonder, is there like an inflammation issue that the progesterone is bringing forth that is then causing the swelling or bloated or whatever it is. I think also it can be a mineral deficiency as well too. For women, that's way more predominant with women, especially menopausal, post-menopause. I think women naturally just like are so much on the go.
They don't drink enough water. I think it's a struggle for women to get enough in versus a man. That's just what I have seen working with women and working people. Minerals can definitely play an impact. There's already a mineral deficiency there. Plus now we're adding like hormone replacement therapy on top of that. You're going to be even more mineral depleted. So I think that has a big role to play in here as well too is, you know, being better with your minerals, especially as a woman,
making sure you're getting your taurine, your magnesium's in, um, because that's like the foundation. Yeah. Yeah, definitely is the foundation. I'll say that's like the one fix for most women. And then on top of that, I think GH or GH peptide, MK777, all great. DCIP and epitalon can be great, selenke, whatever, like, if it helps you. Oral epitalon can amazing for sleep too. Yeah. Inacetalepitalin, there's some people that make inacetylepitallin as a capsule now.
Honestly, that works as good as the injections. A three milligram capsule of that, which is good, is the one milligram of an injection. So you could do that. Works great. Melatonin, obviously, oral, transdermal, melatonins, nasal spray melotonin. Those are all great, I think the other important thing too, this is going to be like the boring part of this answer. And I say this because I was actually filming a podcast earlier today and we went very in depth, the guy that I talking with about this, sunlight. how many people watch the sunrise and get two hours of sunlight during the day and watch sunset?
Very few in today's realm. And when I see someone struggle with sleep, I think perimenopause is obviously a hormonal shift. Sleep is going to be affected regardless. However, what we can do is set up a foundation to like where everything else is gonna work better. If you are not getting at least like an hour to a sunlight, there's going to be a problem. And especially, this is where I think too, I to the perimenopausal autoimmune woman avatar that I know is out there that we talk to so much. A lot of these women, like you said, are high stress situations.
Even if they're just a stay at home mom, that's even more high-stress than even having a job somewhere sometimes. Yes. They wake up at 4 or 5 AM, which is not natural because it's still dark outside. Mm-hmm. they are doing two or three hours of work for the day, whether it is working out, housework, job work, whatever it is, before the sun even comes up. So that's messing with your circadian rhythm to which your sleep is going to be destroyed. Then you go through the day, and then you're under fluorescent lights all day. You're not getting proper light exposure throughout the days. That's impairing all this, also affecting your neuroendocrine system.
And then nighttime rolls around, then we have artificial lights at night. We don't see the sunset. we We have all these lights in our house, our TVs and everything. Mm-hmm. and Then we EMF exposure. Yeah. Top of that. How close is your smart meter next to your bed that could be affecting and sending EMF signals? Do you sleep with your phone in your bedroom? You sleep your your in bedroom. This is what people are up against in 2026. And so when we look at sleep, it's like, look, at all the things that we don't have in our favor. What can we do? I know we're not going to eliminate all those. Like, what can do to mitigate those?
And like on the podcast we were talking about, a lot of times people know the nighttime routine is bad. They may or may not adjust it, but they know it was bad, A lot of people don't realize that getting up early, how bad that can be before the sun. Like he was talking about the importance of like wearing your blue light blockers. If you're getting out before 5 a.m., wear your Blue Light blocker. It's more important then because now what you are trying to do is tell your body awake when it should be asleep. And then you like before sunrise and it's having a bad effect. there, which I thought was pretty interesting.
So again, I realized like when I say two hours of sunlight, that's impossible for a lot of people, but just understand that that until you do that, all those other interventions that we talk about, we're not going to do as well. I will also say, as I was talking about circadian rhythm, VIP is a great peptide to help reset circidian rhythm. And so VIP can be great for circadian rhythm helps a lie in the hypothalamus, align the and rhythm to what is more natural. And so for shift workers or people like that that do have issues, VIP can be great for working. I think it's in the hypothalamus to help with that.
But again, those are all things. Again, sleep I know is kind of one of those. It's an ongoing battlefield to which people are looking to conquer. We're always trying to sleep better to make it better, but it is going to be different for everyone. That was good. A very relevant topic to a lot of people. This might be even more relevant. Reta Plateau. Red at your side plateau desensitization and what's going on. So we've got three questions about RETA not having the effect that people thought they should be getting.
One was a low body fat woman who titrated up to 1.75 milligrams and lost appetite suppression side effects after just two weeks. She was feeling nothing. People wonder if this is a GLP-1 receptor desenitisation. Did it lose potency? Is it a sourcing issue? Does it just not work for me? The second was a significant increase in hunger on Reta and is not gaining weight but not losing either. And the third was getting results at 1.5 milligrams of semaglutide, switched to 2 milligrams RETA and seeing nothing despite needing to lose 100 pounds. So the bigger question is, what does GLP-1 desensitization actually look like?
How fast can it happen? And how do you tell apart whether the peptide is losing potency? Or is dosing wrong or is it bad sourcing? How do we distinguish about this? And then also, too, if it does work, how do you titrate up? Do we add in co-curlentide? Or do switch from rata to turs or ters to reta? Return to semis? All the possibilities. Or for glipron. So, easy way to start. Yeah, you got to break this down. Well, I'm getting all this out there because this is how people ask us questions. I know. This is the questions that I get.
And these are, these, or the thoughts that are all running when people are driving in on the way to work in the morning, this isn't what they're thinking about this, right? Stuff ain't working. Is that my desensitize is that source is it my losing potency? And so to bring that all together, What does it look like for someone to actually get desensitized to the peptide? What should they be looking for to know that that's actually what it is? And then how do they move forward once the peptide, maybe it's worked for a little bit and then it no longer works?
So I would say signs of more so like desentitation to, the GLP is like, okay, let's look at the length period that you've been on it. and how long you've been on that dose for. So let's just say, example, you started off low at like 0.5 milligrams and now you try to turn it up to just to say two milligrams, which is not a lot for some people. And let just you say you'd been two kilograms and you're now eight weeks into your cycle and your not feeling it anymore.
I think something that's really important to know you still need to have an appetite. You don't want it to be to where a point like, like you have no desire to eat because you need it. Eat your body needs, your needs food. Like it's not natural for your not to food, so let's put that into consideration with all this as well too. And I think if you've been on it that long, okay, you can either go up higher with the dose or personally what I would do,
I'd say, okay, let's titrate back down and take four weeks off and then let reintroduce it back in. even if you have not hit your fat loss goal, I still think it's beneficial to come off of it and then introduce it back in rather than keep high trading up, tight trading, up and going up higher and higher with it. I think is a safer route to go.
Yeah. There's an important distinction between appetite suppression and food noise. Now the benefit of like semaglutide into his appetite is that they help with food noise. So I think people often conflate the two, meaning that some people they're like, oh my goodness, these are the best peptides ever. I don't have any appetite anymore. And then some also too are like well, it just reduces food, noise, but you still have an appetite.
I think the appetite is good, meaning I don't want my appetite to be that suppressed when I need it. What is is food noise reduction. Meaning that it's good if I'm not thinking about food 24-7. When I am hungry, I eat and I ate what I needed to. Not more than, but I'll eat what need to to sustain myself, keep my muscle and give myself energy. And I think people have a hard time distinguishing. And so the first thing I would say is like, are you hungry or you have? A lot of food noise. If you're hungry, that means your body needs food. But if you.
Have a lot. Of food, noise, it means. Your microbiome is probably trashed. You're neural connections are probably messed up a little bit, meaning like dopamine and serotonin are off and you craving food mentally when your. Body doesn't need it. versus when the body needs food, it craves it, versus like when your brain just wants extra pizza because it feels good and makes you feel emotionally warm inside. So the first thing is understand that about yourself. That's kind of like a self-knowledge thing of understand about your self. I don't get food noise as much.
Like I could not eat all day, almost every single day. And then at night, I probably would have a little bit of food. But throughout the day I'm never thinking about food Whereas Taylor could be a little bit different to the point of it being like, she will fight me if she doesn't have what she needs. That's self-admitted. So I think that's important. And then I I think when it comes to red trutide, the appetite suppression almost seems to be more of a bug, not a feature.
And what I mean by that is that I, think it's like week 36 on eight milligrams of red of truetide. The appetite, suppression was non-inferior to placebo, meaning that on 8 milligrams or what a third read a 36 weeks in people had no more appetite suppressant than the placebo that they were giving them. Yeah. However, what they did have was all the fat loss, all of the benefits that were happening. And so I think with Reto, it's actually interesting as a lot of people take Reta and they're thinking they are going to get this overwhelming appetite suppression like they do with their Zaptide or Sema Glutide. I actually don't think that's one what it is really doing.
Really what is doing is changing the energy state in your body to melt fat off. Yeah. And I think where a lot of people get confused is like, am I saying that you can eat like a dumpster fire and just take Reta and everything will be fine? No. But I thing what's confusing to them is they can kind of eat, in a lotta cases, a wanna whatever they want, like my father-in-law, he takes Reto, eats whatever he wants, and he just eats, does he ever, doesn't really talk about appetite suppression. He just eat whatever. No, no he really does eat.
I mean, yeah. He probably eats like two slices less of pizza than he used to, but he doesn't pronounce like, Oh man, I just can't eat anymore. No, he does say he definitely has noticed like how much his appetite has, like he's cut back. Like he can, He physically can eat like How he use to. Yeah. I think, another, there are two, foundational pieces here that I feel like I'm beating a horse when I say this, but where are you at with your macros?
Because so many people don't know their macro counts. So many of you don' know how many calories they eat in a day. Even people that are using these, not all people, I would say a majority of people still don''t know there macro count. That makes a difference and stop weighing yourself on your home scale. Like, That like frustrates me so bad because- It's not really telling them anything. It is not telling you anything, you need to go and get a body scan done, like a bod pod or a dexa scan, done to really know how much body fat you have
versus how muscle mass you. Because muscle is denser, so therefore like 140, 145 pound woman can look very differently depending on how that can look very different. I know I looked completely different when I was 145 pounds with 30% body fat versus 144 pounds at 16% body fat, totally different look,
same weight size. So I think that's also a big one as well too. Yeah. I Think the larger question people will, we can talk about the nuances of all this. What everyone goes back to is what do I do when it stops working? And the question is like, what does it mean stop working is that the appetite suppression is not there. It's usually two things. They don't have the apatite suppression or they're not losing weight anymore. To the weight loss question, assuming everything else is controlled for, meaning exercise, diet, lifestyle, nutrition, all those things.
When you stop losing weight, assuming that you need to continue losing, weight that is when you up the dose. Yes. Now I think that happens less often than people think. That's not every four weeks. Like a doctor would say, Hey, for weeks you, you stair step it. Sometimes that might not be for a year or sometimes it might actually be four. But it's going to be different for everyone. And so I say okay, are we desensitized? Do I still need to lose more weight? Then if everything else is not working for at least four weeks, then I would up the dose.
So I'd say, OK, if we're holding steady, and I go, If you feel like it's not work, give yourself four more weeks. And if it continues not to work then you could up that dose, I think that would be the answer. Then I thing to the appetite suppression standpoint, hey, you really want to suppress your appetite, there's a ton of stuff out there. There's coagulantide, or four-glyphron, Now, whether you could use that with a GLP, I think that's still up for debate whether or for Glepron with the GLPs. I would think it would bind to the GLP1 receptor with more affinity. But if you're taking RETTA, you are still going to get the glucagon and everything in the background.
So yes, that would suppress your appetite and get fat loss benefits of Reta. I mean, technically, like, it's not, this has just been from like experimental process, but also low dose nitroxone. I feel like it does reset receptor sensitivity to GLPs there. Again, This is just from experimental purposes. There's no like studies that I'm aware of that this is been studied and tested. On people, this is coming from like my own personal experience, Hunter's experience.
And then the feedback that we've gotten from other people that have used it as well too. But I definitely think that definitely helps with receptor sensitivity. Well, it's modulating the immune system response that the body's having. That's what, when we talk about receptors, that's, what's happening is we're having an immune response and you're building up a tolerance to it. and LDN is going to modulate that. So it keeps it from happening. It's just going kind of keep it in a tightly defined range. You get more bang for your buck because you're not going have that tolerance build up as fast or at all in some cases.
I take it for other benefits, but that's a nice side benefit. Yeah, that is a side benefits. That's not, I wouldn't say like, dad needs to be like taken in order to re-sensitize yourself to GLPs. But I think it's I think when it ultimately comes down to, you really have three options. If it's not working. So like, let's say it not work. You can either up the dose. And I, think it some, for most people, there's some dose to which you're going to get results.
Yeah. Might be two or it might be 20 kilograms. so you can do that. Get up to dose, You come off of it. To which I would recommend you taper down. Don't come of cold turkey. Take it down, go off for eight, 12 weeks, whatever you need to do. Or you can just stay the same. So you could come off, up the dose, or stay same, and I think if people just stayed the the in a lot of cases and they worked on everything else, I've watched Taylor's dad not change his dose of Reddit TrueTide again to the person that's not really doing anything.
He never changed his dosage of reddit True Tide. Even at two milligrams over a year without stopping, it still kept working. Yeah. But he was losing one pound a week. Well, you're going to hit a plateau. Especially if you have a higher body fat percentage to lose, it's kind of like you hit like a peak, and then you kind maintain, maintain. And then it is more like, a slow, steady drop that you notice. Whereas I think people get this dramatic change right away, within the first eight weeks.
It's gonna be like that forever. They think it's going to be that for ever. But there's something that happens after like eight to 16 weeks of being on them that like you hit that peak and then you kind of like, you'll still keep losing, but then it kind just becomes more of a slower process. Whereas in like a year later, like and I, that's how I feel like with how we saw it in my dad. Yeah. Then you're like at your later. Oh, wow. And I think that where sometimes like people like this is like I don't know if this is like kind of like the placebo effect.
I feel like I'm feeling people is that like, they like say like oh, like you know, GLP ones did great for me the first like six months and then they just stopped working. And it's like... I think what people was like if you don' have that bam reaction constantly, they think it's not working anymore. Yeah, they want the shock and all of it. So that would be my recommendation is like, look, if it not work anymore, you have three options.
You can increase the dose. you can taper down and come off, or you just stay where you're at. And then it becomes like okay, well what if we add in other stuff? Do you need other appetite suppressions? do you other fat loss agents? Yes, do need hormones. Yes you probably do hormones, which is going to be a huge piece of that. There's a study that came out women on BHRT, which I don't even think included testosterone, it didn't say in the study that I can remember, but just women that were prescribed BHT on trisapatite had 35% more weight loss than women who did not, milligram for milligram,
as much as they can control for. Well, look at my mom after just like, cause she was using GLPs, a year ago, but then she's been on HRT for like six months now and we've seen a huge change in her physique recently. And it's from introducing testosterone. Yeah. So that's also too, is like, I know most of the people that are telling or not do that. I hope they are, but I know a lot of them.
So that's kind of what it is. We could talk about that for three hours. Like, how do we get the most out of our GOPs? How do you get them to work? And I think that really comes down to that? Last one is, I'll just cut to the heart of the question here. Everyone wants to use a ton of peptides. They see a research website that has 50 different peptides on it. And they have all these things they want to fix.
How do they actually stack those peptide? And it's really hard from like a content angle for me to just go say, here's the stack. I mean, I can create stacks for, hey, you have brain injury. Here's a stack for this. If you're fat, your stack's for these. You're sick, have an immune issue. Your stack is for those. But a lot of people, they have all those things. And they get so overwhelmed. They either don't do anything, or they buy a bunch of stuff, and they use it. and They don' get any results. Yeah, They're just overwhelmed, analysis, paralysis.
How do we actually think about building a stack? I always like to have things in categories. If you look at the peptide cheat sheet, there's categories, whether it's cognitive, immune, fat loss, muscle building, like there are all these like categories that we have. So I like to break it down on to, okay, what is the main goal?
Is it that, we need to lose, you know, 30 pounds or do we a broken foot that were trying to heal? Or do have some type of autoimmune issue going on right now? I say like, what the main category is. Okay, so let's just say we have somebody, I'm going to use this as a very basic example of, You know, have 30 pounds to lose,
but they also have brain fog. They also want to also, you know maintain muscle mass. And they, also you want it to help their immune system, But their system is fine, they just want the extra boost of immune systems because they travel. Like I feel like that's like the average kind of person, the majority of what comes to me. Um, do I have ones that come to me because they have like severe autoimmune issues going on or there's like they're in an injury recovery mode?
Yes. But this is just kind of like population wise majority of the people. And I would say if I'm looking at somebody, I say the 30 pounds is the most important because right now, if you don't lose it, you're gonna keep going up and that's gonna be more detrimental to your health. So when it comes to building the stack, focus on that, okay? So that gonna some type of a GLP. Okay. What was also going to go along with that is that we also want something because they're in a fat loss phase.
They're going be in calorie deficit. Now we want to make sure we're also adding some type of muscle protection and in with there too. So that's when I'm going to come into, okay, my muscle growth hormone releasing peptide category. Put one of those in there, whether it's a tessemorellin, ipamorelline, MK777, CJC. You know, you just pick one those categories to then add in along with your GLP.
Okay, start with that. That's our main goal. If we need to then add in a BPC or a TB 500 because they've like hurt their knee exercising, we wait until that happened. We don't necessarily need add that in right away. I would say, especially somebody new, you start off lower and then you can build into there. Okay. So we have that going. they've adjusted their on that for, you know, four weeks, okay?
Well, now they kind of want something to help with the brain fog. Well the GLPs are going to to with a brainfog. That's gonna be helping with it. But let's say they want something that they now feel like they need a little bit more of an energy boost. That where I'm gonna now go in there and start looking at the mitochondria categories. Okay, let see where they're at with their mitochondrion. I think that using SS31 is a really good foundation mitochondrial peptide to use because that's going to help repair any of the damage mitochondria that
is there, but it's also going to help go in there. Repair it is also gonna go and also help give them energy because if their mitochondrion is being repaired, their energy is going be cleaner. They're gonna have more energy going before introducing any of the other mitochondrial peptides. I think that's like the foundational one to start with. Yeah. I kind of think about it like this when we're doing stacking because all that is amazing is one, the first question I think people should ask,
what peptide, is what is my bleeding neck problem? Meaning if you saw someone on the side of the road and their neck was bleeding, and what would you stop and do? Stop and try to stop the bleeding. The most important issue in that person's life is stopping the bleed coming out of their And the first question I would ask them is, what is your bleeding neck issue? And someone may not have an issue and I'm going to talk about that, but what's the bleeding issue. Okay. Now pick three peptides to fix that and just do that. Cause pretty much any issue, I mean, some, there would be more pretty, much, any issues you can address with three, three different peptide.
And so is it a broken foot? Like you said, is that obesity? That's most people's. Most people bleeding that issue is they have fat on their body that does not need to be there. And so is it obesity? Is it an autoimmune disease? It is a brain issue. Is that whatever? And just pick three peptides. Sure, you can do more, but just for the rule of thumb, bleeding neck, the three peptides, okay. Let's say we take eight weeks, 12 weeks. We get that fixed. Now I'm like, Hey, I've been a pretty good spot. Maybe it's longer because if you're obese, it might take longer.
Now we've reached where it gets fun, right? Where healthy people get to sit and thank God we have our health, but we get sit, and say, hey, what can I do? For me, our bleeding neck issue right now is fertility. Everything I'm doing is oriented to fertility, so that's what I've doing. And so I have the peptides that I am using for that, that is what it is. I don't really concern about other stuff. It's in pursuit of that goal. Okay. I fixed the bleeding neck. Now what do I do? Well, there's five categories that I think everyone addresses.
That's ocerone and reproductive hormones. You get that fixed. It'll be good. The next is going to be thyroid, fixed thyroid. Next is gonna be growth hormone. And so I'm going do something to address growth hormones, whether it's human growth, hormone growth from own peptide, MK seven, seven seven whatever the next. Is going be insulin sensitivity. and that's where our GLP is. Going to come in. And if you address on a regular basis, I would say like that is like the stock. You can always have something in those chambers.
Mm-hmm. you're going to be good. I think everything beyond that, is just gravy. And, if think about retitrutide, right now that's the closest thing we have to like a super peptide that does everything. Like if he just had one peptides, what would it be? What's everyone to say? Read a true time, right? Like the, what a trick question. She was thinking I was going to do that trick questions. So it's not a question, but it doesn't do everything yet.
But what if one day we have a peptide that does testosterone, that doesn growth hormone, does thyroid, the does insulin sensitivity and does mitochondrial health. That would fix 95% of everyone's issues. And then the rest would be there. I think one day we'll probably get there, maybe in our lifetime. Maybe not. But that would like a super peptide. If you had one thing that gave everyone the testosterone that they needed, the growth hormone they need, and the thyroid they'd needed and insulin sensitivity and mitochondrial health, it'd be a superpower peptides.
And until that time, those are the buckets that I think of. If you fix those things, I would say that's going to cover 90% to 95%. And then any peptide that you put in after that is usually either for the bleeding neck, inflammation, obesity, whatever, like fixing that, or you don't need it. And so I would say, that would be how I think about stacking, is like, fix the bleeding neck once that's done. Cover those five things. If you do those things, the rest, you're really just getting into play mode of saying, hey, I'm going to try this, see what it does for me,
and see if it can take dihexa one day if you've got a lot of work to do. That's not a bleeding-neck problem. It's one of those foundational things but, yeah, your probably going get more emails written if your doing di-hexafor a day. And that I how think of it. Out of the infinite possibilities that are out there, I think that's the simplest way. If people just understood that as a foundation, it would make a big difference. I agree. Are you going to ask me something? No. You sure? Mm-hmm. Well, on that note, maybe one day we can hope for a superpeptide.
Yeah, think it'll be interesting, like a SuperPeptide for testosterone. It probably can be. Meaning that you had a peptide that was so good at increasing either two things. Obviously HCG increases LH and FSH, that raises testosterone. Same thing with enclomaphene. But, and a lot of people think I'm like against enclomorphene, it's just that I think testosterone is better, but like I wish more people would take enclormaphane
if they're not gonna take anything. I'd think it would be absolutely better. It's better than nothing. And you can take that if you're like, even if your like 24, you take and it not going to have any like downside. But like, I think also too, there's an agent that is being worked on right now called ACE 167, and that increases cholesterol synthesis in the testes. So it doesn't rely on the pituitary. It actually will just make the tests make more testosterone. And so that could be really interesting to see where something like that goes.
It might not work in mice. That works, but I'd think it's in human trials right now with a biotech company. So maybe it doesn't work. But, um, yeah, that would be like the one, I think all those other issues are like pretty addressable with peptides, But the, one would like, how do you get testosterone, probably thyroid too, out of a peptide to be therapeutic at the levels that now hormone replacement is. Yeah. I don't know. The issue is to get it to saturate the receptor in the same way that testosterone administration saturates the receptors.
Well, I think also too, it's just like a molecule size as well. Well, there's that piece of it, too. A peptide is a signaling molecule, where a hormone is building block. And it's kind of the difference between hardware and software. It would be like relying on software to create hardware. You've got to have the building blocks. If I was trying to write a software program to make a new MacBook, you can do a lot of stuff with software, but it never Manifest a computer out of the software.
Yeah, maybe one day like AI would be so good I'll just like build its own computers. And then at that point it would probably not even be around but anyway On that note, that's all the questions we have. So in closing, thank you guys so much for hanging out with us. I always say we the best audience in the world. Whatever shape, fashion, or form it is that you support us, whether it's using our codes at places, being on the email list, submitting us these questions because you are awesome and we get so many and it so helpful to us to know where you're at. Submitting questions, sharing with your friends and family.
That's one thing in that age of shadow banning and censorship and whatever. The more you share this with friends and family that you know is helpful, it goes so much further than the algorithm will ever go in trying to promote us. So thank you guys. You're out there that are doing that. But thank, you again, just from the bottom of our hearts, thank. Without you, we don't exist. And I always want you to know that and just make sure to submit your questions and we make we will get to them. Taylor, do you have anything in closing? Thank you guys so much for sending in all the questions.
They're super helpful for a lot of others, because if there's somebody else thinking it, there are probably 10 more people thinking the same thing. So thank you for setting in the question. Yeah. And then if 10 people are asking it then I know 10,000 people. Are thinking, yeah. All right. That's it for this one. We will see you in next one and go forth and have an amazing day. Bye guys.
