Reader Mailbag · Episode 2

0:01 you Hey everybody, this is Hunter Williams. I hope you're doing amazing wherever you might be in the world. Today I have my lovely wife Taylor here, and we're going to do another Reader Mailbag episode. This seemed to be something that you guys really liked for the first one we did.

0:31 So we wanted to revisit this. And what I've done today is we have six, so we'll see how many we get through in about an hour. Six different questions. And these are actually kind of synthesis of some of the questions you guys asked because a lot of them end up being very adjacent to each other. So what we're going to do today is go through these and we kind have them grouped into categories. But I thought this would be good because these questions we can kind take like 10 or 15 minutes a piece and really break down. I think it's a good balance of men and women's questions together.

1:02 That's obviously why Taylor is here with me to help kind anchor that side of things. and go through those, and hopefully you find it valuable. As always, before we get started, just make sure that you're on the email list. Obviously some of the things that we're gonna talk about today, probably a little sensitive, hopefully they don't get taken down, but that's the best place to stay in touch, both with myself and with Taylor, in case we got shut down off of any platforms. So make you do that. And if you like getting your questions answered, obviously the best place to do that is inside of our private group. It's called the Axion Collective.

1:32 So that link will always be down in the description of wherever you're watching this. But again, thank you guys so much. Without you, guys, we don't exist. Taylor, how you doing today? I'm doing good. Awesome. I think these are good, I thing people like them. Obviously they're a little bit different vibe than the live streams that we do, but I thinks still useful. And with these, the livestreams, are really want to make a point to answer everyone's question that comes on. Usually we're able to do that within about two hours. But with these, some of these ones that I get submitted are a little bit longer. And also, too, I forgot to add, make sure that you submit your questions.

2:05 I know a lot of you guys do a good job of submitting those questions, but that link will be there. It's just that length that leads to a submit form that can put in whatever, and then that goes to my email. Then I log all of those on a document. I think this will be good. The first one we're going to start with today is around women and autoimmune disease. And so hopefully you can help lead us through that. But for those of you that don't know, 80% of diagnosed auto immune disease is from women. So only about 20% are diagnosed.

2:35 Autoimmune diseases. I mean, I, think more men probably have an auto-immune issue than they realize. but the diagnosed autoimmune disease, we see 80% of that coming from women. So we had three different women write about this. I'm just going to kind of give the background and we'll talk about how to walk through this, but. We had one woman ask about peptide protocols for women with lupus, which is an autoimmune disease. The second is managing systemic scleroderma, Which I believe is a skin issue and is trying to stay off pharmaceuticals and rather use peptides.

3:05 And the third is looking for a protocol for rheumatoid arthritis. So that kind of gives us a good spectrum of auto immune disease, but the question broadly we're going to look at it today is how would we approach autoimmune disease with peptides in a structured way and what would be the foundational stack and how would we think about that, especially for women with auto immune disease that might be a little bit different for them compared to a man that would have auto-immune. Yeah, definitely. I would say one, the main peptide when it comes to dealing with any kind of autoimmune disease is going to be foundational is thymus and alpha one.

3:43 That is gonna be the foundation for auto immune. So I think that honestly like that is a good starting point for any of these auto-immune conditions. And then with some of these, we can layer in a couple other peptides. So let's take the lupus one, for example. Like, what would you also pair with the thymus and F1 with for lubus? Well, even before, and I think this is diamond's alpha one, I would say would absolutely be the foundational peptide for any sort of autoimmune disease.

4:15 If you think about auto immune disease, basically the body's in a state where it is overreacting to something that is going on. So basically, the immune system is overtriggered to say, hey, something is wrong here. And I'm going to start to create all this inflammation, all these systemic issues to let you know that something has wrong. Whatever it may be from, it could be a certain procedure. It could from stress. I think a lot of women's cases, a of it is a stress-related issue and a hormone imbalance, but I it's really stressing the body because I was diagnosed

4:48 with rheumatoid arthritis prior to, and that's what got me into the world of biohacking, peptides, hormone replacement, everything is what led me down this road. And I have no issues with it today. Well, I think the good thing is, in a lot of cases, it's solvable. And I don't say that. A lot times it feels like there's no hope. I think also the one thing that I thing a lot of people don't realize, to really get a true diet, it's actually very hard to get an actual read with a

5:18 lotta these autoimmune conditions, especially rheumatoid arthritis. You have to catch it bloodwork-wise right when there's a flare-up. And I remember this when I was going through testing and I going to seeing all these different doctors and specialists and everything, is that basically I never could get like black or white answer, it was always gray. And anytime there's rheumatoid arthritis, they're also testing for lupus at the same time. They do coordinate, correlate with each other.

5:48 So the thing is, is that like a lot of it can be solved. I was like given the option to take, you know, prescription medications and chose not to go down that route, but that's like, I think sometimes with certain autoimmune conditions, it's always a gray. It's never like black and white. Well, here's, my rub with, and this is what I'm going to say even before thymus and alpha one, I, think that's the foundational peptide and I promise we'll get into the peptides of TIG. it is a hormone deficiency almost always.

6:19 Almost always you can look at a woman with either lupus The skin issue I think is a little bit of a separate thing because that's not always hormone related, but the hormones could be a foundation to helping fix the gut, which would then come in. And then if you look at rheumatoid arthritis, obviously like a lot of hormone dysregulation probably there too. So especially for women, they don't get diagnosed with a hormone deficiency the same way a man would. If a men has a total testosterone of like 150 or 200, The doctor's probably not even going to say like, oh, you have a hormone deficiency and you're a candidate for TRT, but they can at least say, like your hormones are low.

6:52 Whereas a woman, a lot of times you'll see them with a total testosterone of maybe like a 15 or a 25, kind of like very similar to you. Like your total testosterone, when you had all that going on, it was probably like 10 or 20. Your free was basically a zero. It was like 0.1 or 0 .2 or whatever. And during that time I was also on synthetic birth control. Right. And so we look at autoimmune disease and it's like, oh, I got bit with this auto immune disease bug, whether it was lupus, rheumatoid arthritis, whatever it is. It's one, stress on the body, two, the environment going on, you know, or whatever is in your case being a hairstylist exposed to a lot of chemicals.

7:29 But then we see that it's like, okay, well, what is the picture of the hormones for a woman? Let's fix that first. And I'm not saying that's going to heal the autoimmune disease right away, but it at least going set the foundation to like now where the peptides come in and do a really good job getting rid of inflammation. I think one of the big things too is estrogen, especially dealing with the rheumatoid arthritis. That's huge. Yeah. Testosterone first, but even then the testosterone aromatizing into estrogen. But then even some cases too, in the case of a woman that's probably post-menopausal, she's going to need estrogen as well.

8:03 So I just want to throw that out there. And again, these are the deep dive questions. This gives us the time to be able to walk through this story. I won't just rattle off three peptides and leave you hanging. hormones first. And that's where I think, especially like something like lupus, like how many of those women could benefit from testosterone to, again, I don't say that it's going to solve everything, but it is at least going get them moving in the right direction to be able to heal, whatever it So that said, make sure your hormones are checked. Make sure you're thyroid is in check.

8:33 And if you need desiccated thyroid or whatever it is that you are addressing your thyroid with, please make that's good. Also, too, I would throw in, well, let's keep this for the peptide. So thymus alpha 1 first. Then I would say after that, to me, it would probably be for an inflammation thing. And this could be rheumatoid arthritis. This could lupus too. I'd say BPC 157, TB 500, and KPV. Like I wouldn't lump those in together. You could really say GHK, but just for the purpose of keeping this simple. It's like a 50-50 whether people are going to have like pain.

9:10 after injecting that peptide. And I think if somebody's already like dealing with so much inflammation, I would say keep it out because it's going to be and keep everything a little bit more gentle because all those peptides are going be more general like the BPC, TB 500 and KPV. So I wouldn't I will not do the GHK. Even though it is beneficial, i would not put that in there, especially in the beginning for somebody. Yeah. And so we have that myself a one BPC one through seven TB 500 KPV. I think that right there alone will.

9:42 again, maybe not solve everything, but is at least gonna, man, like probably like 70 to 80%, whatever's going on. I think to the skin issue too, to like some autoimmune skin disease or issue that someone's having, those are gonna be massive players. Yeah, especially for the skincare. And again I don't need to go into dosing, obviously with those 500 micrograms of each of those is fine daily to do. Thymosophil one, probably one milligram per day. But again these are going to be like regular doses that you'll see on the cheat sheet. I would do that.

10:12 I think from there you could potentially use something like an LL-37. Yes. Ll- 37 could be really good for arthritis as well. There's a lot of evidence around that, a lots of evidences if there is some sort of like Hashimoto's or skin issues. That's going to be very beneficial. Yeah, that could be a microbial thing. Yes. LL 37 could help a lot. Definitely will help. And then I think so as to not overwhelm people, the last thing that I would have in that protocol would just be microdose of a GLP.

10:43 Yeah. Autoimmune is interesting. You know what's kind of interesting is I don't see a morbidly or like vastly obese people have some of the autoimmune manifestation that sometimes even thinner or skinny people. Now, I'm not saying that overweight people don't have auto-immune disease, but in terms of like the really bad cases, it almost seems like people that like have this auto immune manifestation, a lot of times are not grossly overweight.

11:15 Like it, and maybe that's just because of people that are overweight, that their main problem and they know it. But it's almost like sometimes with this autoimmune disease, it people are actually like trying to be healthy. I think it is also the stress on the body of maybe hyper fixating on like maintaining physique, maintaining health and to the point like, it becomes a stress on the body because you're pushing yourself so hard. That can also lead into it as well. And I think, again, not to go back to the hormones, but thyroid function plays a big role with any kind of autoimmune issue.

11:54 Yeah, absolutely. And a lot of times it's Hashimoto's, Hashimoto's thyroiditis is the autoimmune issue there. Yeah. So I'm not saying that, one, it is not that exclusive to people that are not overweight. It just seems like the worst cases of auto-immune, that person's done a lots to keep themself not obese. But then it almost like this stress kicks in and hormone thing, stress thing and whatever. I don't say that to say someone that's overweight can't have auto immune disease or that that people that are autoimmune diseases that thin are any different

12:28 than people who are overweight. It's just that it seems to be for a person, it seems like a lot of autoimmune are people that have tried to do the right thing. A lot. They've tried. To live healthy, they've exercised maybe too much. So that's a shrink, but I think a GLP and even in this case, terzaptide could be more beneficial than retitrutide. I. Think because it doesn't stimulate the nervous system and sometimes the auto immune disease is manifesting because the system has been overloaded. Yeah.

12:58 the highest and best GLP to lose fat. But for the case of autoimmune disease, sometimes a triseptide, I think could be potentially more beneficial because of the lack of nervous system activation. Especially for women. In these cases of these questions were sent by women, I think that trisapatite is going to be a lot better for a woman's nervous system. If you are dealing with any kind of like autoimmune issue. Yeah. Trisapetite. Is going. To be better. For that, for our microdose amount.

13:29 Yes. Rhetorotide is still going be the best for fat loss, but if your nervous systems already taxed, the retoratide's going tax your system even more. Yeah. And I think it's easy to bring someone in, especially intro. Yeah, exactly. Especially if they're new to GLPs, they are new the peptides and they wanted to do this. I also think too, you can start on a micro dose of that with relatively like no side effect and to go back to like people being lean. In some cases they might not need to lose a lot of weight. They might need change their body composition.

13:59 Like you might have not enough muscle and too much fat, but they may not necessarily need a dramatic No, I think just like a smaller dose can be, can make the biggest impact for inflammation. And that's what autoimmune is, is inflammation in the body. Yeah. So I've seen low doses, meaning like 0.5 milligrams, one milligram, 1.50 milligrams per week. Uterus Aptide really do well for auto immune disease and help, especially with that rheumatoid arthritis helps a lot. with that. Even I notice I just have less soreness from training.

14:29 I have a GLP, a micro dose GLPs, I recover better. And so I think just to the systemic inflammation, and then also too, we talk about gut health, all those things are going to help with good health. That's going go back to, especially with the skin issue and everything. So to recap for this one with autoimmune disease, kind of like there's a ton of different stacks you could do. We could get into mitochondria stuff and everything, but I think for the purpose of like, Hey, if you had, what would that be five peptides or let's see.

15:04 six peptides because we don't want to like throw too much at it. Six peptide to really get started with thiamin sulfa one, one milligram a day, KPV, BPC, TB 500, 500 micrograms a and then 100 micro grams of LL 37 for four to six weeks. And then I would say probably, you know, around one milligram ish of turzapetide. And that would be kind of how I think about it with the hormones in place. But then you get those things done, that is going to solve a lot of problems for a whole lot people.

15:34 So that's how i would think. Anything else on that one? No, I don't think that was good. Next one, this is going to be a little bit of a personal journey for us. And we're going talk about our fertility. So we get a lot of questions. There's obviously a of listeners that we have that are interested in fertility, obviously that's like our prime, you could call it health goal right now, is to conceive a child. We've gone back and forth even before we started doing this, like, do we make our Fertility Journey public?

16:04 Now, I don't make any illusions that were like famous or anything like that by any means. But even just being in the public eye where you have people that keep up with you or want to know about our lives like it's very personal when you talk about fertility and so that's one thing that we've debated should we even do that because when You do you start to get everyone's opinion and it can be when your own your journey for something to have the opinions, whether they be positive or negative towards you, it can just be extra stress that is not needed.

16:39 Particularly when you talk about fertility itself, that's something where you don't need any stress already beyond the life stress, the work stress and having that on top of it. So we get asked all about our fertility. One, are you pregnant yet, Taylor? No, as of this recording that we know of, she's not pregnant. I think also too, like, This is also something that has not been, I don't want to say not done, it has been publicly talked about.

17:09 I do not know anybody out there talking about peptides fertility and like the way that we're doing it and not doing through like an IVF or anything like that going through. Yeah. And obviously we are nowhere near having to do that. Literally just for context, this is April that were filming this. We literally just in January said, okay, now let's begin attempting to, Yeah. And so prior to January of this year, which was, you know, three and a half, four months ago, we had not even made that like,

17:42 okay, let's sit down and say, like we're going to actively attempt to conceive now. Yes. Which is fine. But it's also too, I think, We need to break down because this is something that I get questions and I got people commenting me or sending me things a lot too. I think we need to break down like what the journeys are, what we're doing, the negatives that we fight, like essentially like fighting against. Because I a think a lotta people, people like automatically assume that it's me as a female that I'm the problem.

18:22 I'm saying that loosely. As with everything, I think females get blamed for much of the stuff in society. And so when it comes to fertility, it's like you get blame for that. I've had my issues with, you know, we had issues me with fertility. before we even started this journey, which was what got us into hormone replacement therapy. Yeah, I think if you look at you, long-term birth control use, now I will say this, prior to us meeting, you did have an ultrasound and you were told, again, this is just going off what the doctor said, that your ovaries were viable, at least at that time.

18:56 Yes, during that that they were, and I was actually going into I was going down the road and looking into getting my eggs retrieved and getting the eggs frozen to give me a piece of mind. Now, not knowing everything that goes along with that, that's a very intense journey. But one of the things, it's very, very expensive. It was something that I willing to invest in.

19:28 isn't really talked about a ton is that it's not clear. Once you do an egg retrieval, your chances of naturally conceiving percentages actually goes down. So even though like having those eggs frozen would have given me that peace of mind, I've also knew that like, Conceiving naturally was also really important to me as well too. So that was something that like I was taken into consideration and I actually was very fortunate. I did have a doctor that actually very honest with me and they actually told me that your eggs are good.

20:07 That you could actually, I would really highly recommend you waiting and giving yourself a couple more years before doing this process. And I'm actually surprised by that because I think I 30, maybe 31 at the time. It was either 30 or 31. And I'm going to be 36 in a month from now. So like, I was actually very surprised that they told me that. Yeah. At that time, do you remember if you were ovulating?

20:37 I wasn't ovulating during that, time were you on birth control or you had come off? Just came off birth. Control. Okay. We've talked about this, but I just saying for the audience to know like where you're at. And so fast forward to today, since then, obviously years have gone by, four years has gone, like Taylor has started testosterone therapy. Since then every single time, and we've been tracking this even before we decided to conceive, Taylor was or has been up until this point, ovulating, menstruating, pretty regular. I'd say maybe one or two cycles throughout the year, probably because of stress thrown off, but at least the ovulation, when we tested,

21:11 you've at-least tested positive on one ovulations test every cycle that we have tracked. starting injectable testosterone. I was not ovulating when I on the cream. Correct. Or before even starting testosterone, right? So we've come a long way in that sense on your side and by all means and measures that we can measure right now, you're ovulating right. And so the data would suggest that I would be the issue right because I started testosterone going back almost seven years ago now when I was 27 years old.

21:49 And at that time getting a woman pregnant was the least of my worries. It actually, I got, it actually maybe it was like the, one of the bigger of our worries is I did not want to have a child at time. I wasn't in a relationship at the time, not even close to like meeting a women that I would consider. spouse and now, now I am. And so because of that, I was not using any like fertility enhancing agents alongside my testosterone. If anything, was more concerned about like making sure that I did not get someone pregnant, let alone actually conceive. So fast forward to today, when I just did an at home sperm test prior to January, like I basically had nothing there, which is fine.

22:25 That's expected to be when you're on testosterone, that's And so in January is when I really started gearing up, started taking HCG. And just to give my protocol, which I know I've talked about, using 250, excuse me, 1,000 micrograms, HCGs, and I use 1 thousand IUs of HCg three times a week. So 3,00 Ius of total per week, 75 IU's of recombinant FSH. You could also use HMG, I just have the recumbent F SH was a little bit stronger.

22:55 Three times per weeks, that's 225 IUS of common F S H three time per Also doing basically 500 milligrams of L-carnitine at least four times per week injected, and also glutathione 200 milligrams, two to three times a week, injected. And I'm also going to add in enclomaphene. I'll probably do 12.5 milligrams every other day with that. And I'm still taking testosterone, 200 milligrams total per week broken up into three shots. And so basically that would be the quick rundown of my fertility protocol and obviously doing all the necessary extracurriculars with your partner that

23:30 you need to do on as frequent of a basis as possible. That's the plan right now. It hasn't happened yet, but again, we've only been doing it three months and it takes at least three month in most cases for men. 90 to 100 days for that sperm. To even really like generate and be there. And then once you have that then from there, it's like, okay, now it' moving and then it is like at that point, then you actually probably have a window with your partner to like really make it happen. Because then it's like, OK, the tank is full now, so let's see what happened.

24:03 And then you have to even, from there, it also like OK now that all of the variables are controlled for, now we have make sure that it happens. Because even then with everything, It still might not happen. Even for just like the average person attempting to conceive, even with all the variable set in place, its still going to take a little bit of time in most cases to do. Not every case, but most case. Yeah, definitely not everycase. I think that's probably one thing that has been more of a challenge for me is that like in my mind, timelines like obviously got shifted when we wanted

24:40 to originally start going down this journey, it got delayed. And so I think this is something that I wish women would talk about more and be as like the emotions that go along with trying to conceive. Like I know it's funny, cause I'm, I thinking about a lot of the women in life and A lot of the women in my life have been like, I don't know how I got pregnant. Like, like I'm pregnant right now. And it's like so opposite for me.

25:10 how am I not pregnant yet in my mind? But I know, that's like emotionally. That's the emotional side of my brain. I logically why I'm not. And I think probably like what's been harder for me is the fact that like, I really wanted to start this journey this past fall and we didn't, we had to delay it, which everything happens for a reason. Now we're starting the journey in January, but really the journey of like really, truly trying really won't technically,

25:46 I guess, if you think about like the 90 to a hundred days, wouldn't be starting until really may. Yeah. If you said it was 90 days. It's not that it takes, it might not happen, But it's like that timeframe. Like that's emotionally hard on me. Yeah, that's, I think for women and for every month, like that it's like, and I know, even though I, know logically, cause I understand like everything

26:16 behind all of this in the science and the biology behind everything. It's still like every. They're still that glimmer of like. hope is like, oh, maybe this is, Oh, I'm feeling off. Maybe that's why. And it's like I know it like this past cycle like was a hard one. Like I just got like really emotional, like a few days prior to getting my cycle. I knew it was my, but I think in the back of my mind I was like maybe I am pregnant.

26:47 That's really why what's going on. And I think something that I really had after that first day, I had to come to terms of I have to let this go, of being like, oh, maybe this is it, every month this it. Whereas I know logically, chances of it happening really would not be a higher chance of happening until May the earliest. And letting that pressure go it also will help my nervous system because that does put a lot of stress on the body, on my mind every month.

27:25 And then it's, and then you also just, you end up forgetting like the purpose of it. It's really about connecting with your partner. Yeah. I think that is end up being better for the child too. Yes. But I to the point is, like you said, a lot of women are like, Oh, I don't know how I got pregnant. Well, you don' hear all the other women that struggle to get pregnant because a lotta times that's a very private thing that they don''t tell anybody other than their partner. A lotta time it's not even family members.

27:55 And so to go back to bring it full circle is for us kind of made a decision. Do we talk about this maybe in the hopes that it would help other people versus obviously we're not trying to get views or likes off of that versus trying, versus keeping it completely private where we don't even bring up anything. But I think for who knows when it'll happen, maybe it will happen this month. Maybe it we'll take three months, six months. I hope it's not that long, but to the point of the peptides and everything, we're doing everything that we know that can that.

28:25 We've been consulted with really smart people, including lots of doctors to do. And we'll just going to keep, keep doing that and see what happens. Eventually, maybe I have to come off of testosterone. Maybe that is what ends up happening. We'll see where it goes. But I think to the point, that's kind of where we're at. I know there's a lot of people out there in their 30s trying to conceive, maybe in the early 40s. Because I've heard from several people that have messaged us in our early forties about what to do.

28:56 And I for the women's side, take the example of what we've talked about with Taylor to-do. That's really the best thing that you can do, you could use some of the ovary by regulators. but by all measures that we can look at right now, Taylor is the further one and I would be the one that is, the missing piece of the equation. And so for the men out there, I will take what I have to say and hey, maybe there are some extra measures we have go to, but I think for time being, that's where we're at and we'll see where it goes. I think it's also like kiss-peptin, because I get questions about that, about kiss, peptin and fertility.

29:30 And do I that I could help a little bit? Yes, but it is not going to affect you in the same way of using hormone replacement therapy. I don't think it will hurt. Anecdotally, I've had people tell me that that is what both partners were taking and they got pregnant. But in a lot of cases, that don' think those people were on HRT. Yeah. And so it kind of depends on the person. I dont think its necessarily bad to do it. The worst is going to nothing and the best.

30:00 So I think is very low, low risk, high reward. At the same time, i wouldn't rely on that solely to be the thing that you're relying on. to make it happen. But I think to that point, that's kind of where we're at in the journey as of this filming. And hopefully one day we look back on this and we'll laugh and have a little baby filming with us. I Think to the point that kind where were at. For all the people out there that might be a struggle. That is a massive thing that is Hard for people right now is to conceive.

30:30 And so just know that you're not alone and know there's other people. There's ways to make it happen. One of those things is so variable. Every situation is going to be different for different people, our situation's not going be anybody else's situation. when it comes to peptides, hormones, and protocols, that's the best you can do. Obviously being metabolically healthy. I don't think a micro dose or small doses of GLPs hurt there. Maybe at high doses, you would say there could be a risk if the person is starving themselves.

31:02 Like if you use a GLP to starve yourself and then shut down your hormones that potentially could dangerous. But I think actually, if look at it, especially from the female side, GLPS are enhancing fertility if used properly. Used properly, they definitely are. That's another thing too. this been a challenge is like, this is my cycle of where I really start leaning out and dropping my body fat percentage. And I can't do that right now. Which I'm still like, I am still good. And I know like it's beneficial, but again, that's the other stressor that like people don't talk about.

31:36 Yeah. Well, the way we think of it too, for vanity sake is let's get through, hopefully we want to have two kids. We'll see what happens and then get the period of years that we have to children. Then once we decide that that what we wanted, if we're done, then we can have all the fun that doing what we want to augment our bodies in a healthy way. But I think it's like, if you just took a period of your life, whether it was four years, five years or whatever it is, focus on having the children. And if that's what you want, we decide, OK, that for us, then we can move on.

32:09 We have a whole decade of our 40s ahead of us to do all the optimization stuff and tinker with what want do. All right. Enough of that, enough of talking about ourselves. Wow, We could talk about our selves all day, it sounds like. I Think people like it, though. Well, I hope it is helpful. My intent is to be helpful for others. This would be useful and helpful to someone else that's out there or even if it's not, you know, a lot of people that listen to us from their fifties and sixties, even it it not helpful, maybe you have a family member or child or something is going through this right now that it could be All right.

32:45 As if things didn't need to be any more risque of what we talked about, let's talk about peptides and cancer. And we kind of debated this morning. Talked about this. Should we bring it up? I was like, Let's go ahead and do it. If it gets taken down, it's taken it down. We've got three cancer related questions coming from people. The first act asked our general take on peptide in cancer, obviously there's a lot of concern about like angiogenic or angio genic peptids and Cancer or growth hormone peptidies and The next one was about, are peptides safe to use after breast cancer treatment?

33:16 And the third was whether PNC27, which is a cancer peptide, should be run as a proactive protocol against cancer. And so one, how do we think about peptids with cancer? Is there any safe post-treatment survivorship, especially when it comes to hormones? In cancer, can you use hormones after cancer or peptides after cancer. And how do we think about growth hormone peptide and cancer risk? And then we'll talk about the PN27 as a proactive tool. If you don't have cancer, should you use something like that? I'll start it off.

33:46 When I think cancer specifically, I personally don' worry about quote unquote cancer risks from peptid. Now I acknowledge that the pathways when we look at some of these pathways. Yes, you would say that that is in alignment with something that could eventually cause cancer, but so is existing on the planet. Yeah. Anything that we do, our world now is like, it's full of toxic. Your existence, your existence is a cancer risk. just like anything.

34:16 Your mental state as a cancer risk, your mental, state, you're emotional state. Those are all cancer risks. So I personally don't worry about that with peptides, but that's based on the data that I see as much as we can say that there's data around peptide being pro cancer. There's evidence BPC 157 shrinks lung metastases in mice TB 500. Same. I forget exactly what the, the date was. It was long or something else actually shows like a reversal in cancer markers in some studies.

34:46 Also too, when we look at the growth hormone peptides, testosterone actually like improves genomic transcription related to being anti-cancer. And so we'd look some of these things, there is data that even if we said like mechanistically, it's like going to cause that. I personally don't worry about that and that's whether it is like hormone or peptide related. So I, personally, don t worry that, and I think what people could do is if you were in a situation where you're worried about that, obviously if I had an active cancer, I would not go around and basically be injecting human growth hormone or something like that into that active tumor.

35:25 But if we just look at the risk of like living the peptide lifestyle, don't see that being a factor that I'm personally worried. Especially when you look in the metabolic nature of cancer. All these things that we're doing ultimately there to enhance our metabolic health. Yes. If we improve our metabolic health for the long term, I think that bodes well for cancer risk. Doesn't, doesn't mean that it's not possible, but I just think it bode really well. So that's how I thing about it. Now I wanted to ask you, especially for women, cause you work with a lot of women.

35:55 All these women that come to you. I had a history of cancer or have a of history cancer in my family. not for me, but in my family. Now, what do I do with hormones? Because the doctor told me that I could never use hormones because I either had breast cancer in the past or some sort of cancer. The past family member did or had the gene. God forbid you have the jean for cancer now. I can't do hormones. So what am I supposed to do? How would you approach that? I would say read the material about how the WHI study was actually done completely wrong.

36:30 And there is so much of that now has been proven that that study. Was wrong, they were not using bioidentical hormone replacement therapy. They were using synthetic hormones from your horse urine, which is not by identical to our hormones at all whatsoever. So there's plenty of studies on that now. That's very acknowledged. Suggest getting a new doctor and finding one that aligns more with your viewpoints.

37:00 And I think that what we're seeing now is that a lot of the risk with cancer, especially breast cancer with women, a of it is actually from your biological hormones being blocked, your estrogen cells being block, or testosterone cells are being locked, whether it was blocked through synthetic pharmaceutical drugs or whether has been blocked from poor dieting because that takes a big role. Like I know several women that were big vegans and eating like a lot of processed vegan food.

37:35 I think eating plant-based can be very beneficial, healthy. But when you start getting into the process with the soy, the tofu, that the fake meats and everything, a lotta that is actually causing blockaging in your estrogen and testosterone hormone cells. Well, I think when it comes to the conversation, one, the whole conversation around hormones and cancer, we're only looking at estradiol. And one you have like metabolites of estridiol, some negative, positive.

38:08 A metabolically healthy person typically is making the proper estrogens that are healthy, that you would say are not cancer causing. But the thing that I always just want to throw my hands up in the air is like, why are we not talking about testosterone for women? Because all these women are worried about cancer, either from a history or family history. And they're like oh, I can't have estrogen. It's like okay. I mean I know women that had the gene and got full hysterectomy stuff. Yeah, it's crazy. but it's like, okay, maybe you don't take estrogen.

38:39 Like I would say, take testosterone first. And there's actually data that even in breast cancer survivors, that testosterone reduces the risk of reoccurrence of breast. Cancer. Yeah. So that's where I kind of threw my hands up and it was like okay. Let's not even talk about estrogen, although I do, of course, estradiol supplementation or therapy would be important, especially in a post-menopausal woman. But even if they're, let's take the whole like cancer thing off the table, testosterone should be the first hormone replacement step along with progesterone.

39:12 Estradiol should not come in until at least like 90 to 100 days after starting testosterone. And that is practiced in world link. That's what's practiced, in good hormone replacement therapy, practicing medicine. Like that's stated in those studies and those facts. It's like, that just not me as a health coach saying that. Yeah. And that's where I throw my hands up because the people come to us and say, well, my doctor, postmenopausal woman, you know, 62 comes to US. My doctor said, because of history of breast cancer, I'm not a risk or I am not candidate because I can't take hormone replacement,

39:48 to which they only think that means estrogen patches. I was like, whoa, what about testosterone? Because testosterone actually would improve your metabolism. Testosterone would improve everything related at the right dose to prevent the reoccurrence or the occurrence of cancer. And on top of that, you're going to get aromatization out of the testosterone that will then be protective. Then you can talk about bringing in estradiol. So that's how I think about, I personally don't worry about it. There are doctors out there that share that view, thank goodness. And so if your doctor is not one of those people, I would recommend, guess what?

40:21 Just like a doctor, or excuse me, just like, a lawyer or an accountant or your landscaper, you can find a new doctor. There's plenty of good ones out there. And I realize the insurance piece is a part of it, but we all got to make the decisions that we have. So that would be the hormone thing. The peptide thing, very similar conversation, like I said, with the BPCs of the world. It's interesting because people love to talk about that, but then they don't talk Thymacin alpha-1 helping the immune system to which it would be preventative. They don' talk some of evidence we see with thymalin or epithalon or some bioregulators that reduce the risk or even use as an adjunct to cancer treatment

40:57 like chemotherapy to enhance results to protect the system. And so as much as people want to talk about the cancer risk for some certain peptides, fine, I grant that. Don't use those if you don't want too. Use KPV instead of BPC. You use cartilax instead off TB 500. If you need a healing peptide. And, so use Thymus and Alpha 1. So there are peptides out there. I do want to get to the PNC 27 question. So P and C 27, I'm talking off the top of my head here, so please forgive me if there's any like misquotes of this, but to my knowledge,

41:30 P N C, 27 actually is kind of like a seek and destroy peptide for cancer cells. And so to question of someone would take it basically as a proactive measure against cancer, don't see the need for that. I don't think that you would be inducing harm. I do not see the need to take something that works mechanistically to search out tumor cells and kill them. Now, I grant the possibility that maybe someone has tumor cell and I did not realize it. But if you do, then I would not take that preventively if they are not there.

42:03 I would say if it's more so of like preventing cancer cells, I wouldn't say, and there's no, you don't, your not, You don' know if you have anything there or if he do know and you dont have any I'd say he wants something just like preventative wise. I think running a cycle once or twice a year of FOXO4 would be way more beneficial than using PNC. Absolutely a thousand percent. And even if you would say you're higher risk and you are older, family history of cancer, maybe two cycles a year, a FOX04 DRI.

42:33 I think like the average like healthy, active, like. anti-aging loving like guver like us once a year, that's a good cycle. Yeah. And that would I think be the answer to like, Hey, what do I proactively do if I'm, cause a lot of people, they can't sleep at night cause they're worried about cancer, unfortunately. Cause for whatever reason, but I would, I wouldn't say that. Would be that answer that that was not for one, obviously too. You could do that same thing, even if you weren't sick to use that, proactively, but I just personally also too, we look at GLPs retrotide.

43:07 We'll see this probably in humans. I know semaglutides or Zaptide should reduce cancer risk. Retrotides actually shrinks tumors in mice. So they give retretide to mice that already have tumors, shrinking the tumors. And so I think, again, just the nature of how well and amazing GLPs work, that would be another thing. And I personally wouldn't say that you need to go get PNC 27 just because you feel like you're going to get bit by the cancer bug. But I would say in the case of an active tumor, I'm not making this recommendation.

43:37 Again, nothing that we say of cancer is strictly just for entertainment and live action role playing. Yeah. I could be something potentially in research scenarios to which a tumor would want to be removed that it could do that. And I like around like one to two milligrams per day. I've heard people doing five to 10 milligrams a day and so do what that will. But that would be my recommendation for that one. Anything else on the cancer? Nope. This is kind of adjacent to this. So this goes to healthy seniors.

44:07 I get a lot of questions from people in their sixties and seventies about what they can do because they're obviously probably don't feel great. And I think a of this comes from senior citizens that not even call them senior systems, but people on their 60s and 70s that are really fit and they exercise a diet, right? They do all those things, they still don' really feel good. Obviously the first piece of that is the hormones. But just to give you examples of what we had today, a guy that was really fit, what would be a hierarchy of how he would approach some of these things? The next one was a woman, specifically, whether growth hormone peptides are safe in this demographic.

44:43 So we'll talk about that. And maybe they're not even the best thing. I think growth normal may be better. Yes. Whether MOTC would different for people over 60. Third, and this is really important to the hormone piece, is about a 78 year old woman Increased brain fog and muscle weakness from taking her statins and her poor cardiac calcium score, according to them, takes HRT off of the table. And so they're on statens without HRTs because of a poor calcium cardiac or calcium core to which they are in massive suffering.

45:13 So how would I think about building a stack for someone in their 60s and 70s, and beyond? And do we have to worry about these growth hormone peptides? and HRT for heart disease. We just talked about it for cancer, but what about for hear disease? Is that something that is off the table? And so I know we both have talked to a ton of people in this age group. What would be your first thing when you think of that? Throw the statins away. Yeah, let's get the layup out of the way first.

45:45 Statins, terrible. Throw those in the trash. I'll just use an example. Let's use and example for this. Taylor's dad, a few years ago, when I met him, was on statin and his cholesterol, believe it or not, it was perfect. And he thought he was a pillar of health, even though he 80 pounds overweight, because his Cholesterol was Perfect. You look at his A1C, his a1c was like a nine or a 10, something crazy. Hovered anywhere on multiple different blood work that he got, a 9 or 10. And so he was basically diabetic, 80 pounds overweight. But dad gone at it, he's cholesterol was perfect because he taking a statin.

46:18 Also testosterone, maybe 100 or 200, somewhere in that range. Very low testosterone. I said, Terrence, do you trust me? He's like, Hey, what do I have to lose? I wake up every day in pain. I don't feel good. You know, I said, go throw your statins in the trash and start taking testosterone. And literally that's all we did first. So within a few months, your cholesterol will stay the same.

46:48 Your A1C will come down. More importantly, you'll feel better. And so that's what happened three months into testosterone. He got the blood worked on again. His testosterone had come up. his A1C had dropped, I think probably about like two points. So it went from like a nine to like seven. and his cholesterol, ironically, had stayed the same. he stopped taking statins. It was so hard for him to get that out of his head that his doctor for years, decades had been drilling in. You've got to take your statin because of your cholesterol. Yeah. But he was like anxious to not take something.

47:21 He's like, what am I supposed to do? What am i supposed do for my cholesterol? I was like you don't understand your testosterone because it's so low. When you fix that, it is going to improve your metabolism and it will fix your blood sugar and your metabolic health and eventually that will lead to improvements in cholesterol. Yeah. And so he did that. Then we got him on a GLP, got them on some trisapetide and eventually retrotide fast forward. Now he's lost like 70 pounds. He actually has like a flat belly now to where he had never seen him. Like I've never. Seen my dad this lake.

47:52 Yeah, lean. I actually did threaten and told him that if he doesn't start lifting weights, I wasn't going to let him continue with, with Reda. I don't think that's going to matter. But anyway, to the point, I say this because this was the exact same thing I had with a family member of they were worried about cholesterol and were taking statins. Hormones were not even in the conversation from their doctor. And we fixed that for them. Then all of a sudden now he's lost 80 pounds. He feels amazing. Like he feels so much better than he did years ago. he has energy, he is walking around.

48:24 Everything in his life is vastly improved. We also did get him on an SGLT2. who does take Jardience now, which has been massively beneficial to him, also to the cholesterol piece, improved his metabolic health. And now his A1C is in the fives, probably like a 5.7, the last time I looked at his blood work and everything. So again, this is a guy that's 69, 70. He'll be 70 this year, or maybe he'll 71 this Anyway, he's in his 60s, 70s to the point of this. And so whether that's a man or a woman getting on testosterone, potentially estradiol for a women, all those things will improve.

48:59 So I say that I'm not some genius or anything. It's just, I knew enough to help him with that. Literally, that it. He did have a bout of COPD to which we helped him like TB 500 and bronchogen. Yeah, my dad also smoked for like, a good majority. Like, I mean, yeah, he smoked. Yeah. I don't know exactly when he quit, just because I think he was sneaking out a little bit when we were younger kids. But like I, mean he's also been sober from alcohol for 30, I think it's 37 years, 37 and then I know he quit smoking.

49:36 I would say maybe let's just say 20 years ago, maybe. But still decades of destruction to the lungs. So we did have a bout of COPD to which gave him some TB 500, some bronchogen. We don't even think we had to use the LL 37 for him because we thought it was potentially like pneumonia infection or something. And within a few weeks he was healed from that and his lungs have really not bothered him. sense that he's told us. And so that's how I think about that is you just give them some hormones, some SGLT2 and some GLP and it fixes so much of the equation.

50:13 Now to the point of the peptides, I don't think that the growth hormone peptide are the best thing to do. I do think they're better than nothing. As we age though, it seems like after the age of like 45-ish, people respond so much better to growth hormones itself at a replacement dose, which would be like one to two I use per day. as opposed to the growth hormone peptides. That doesn't mean I don't think they don' work and it doesn' mean that they can't be beneficial.

50:43 It's just that I see those being so much more. I think growth hormones are so beneficial for someone in that age group. Yes, I agree. MAT-C, I don't think MATC really makes much of a difference, whether you're 30 or you 60. I think it just does what it does. It basically is an exercise. A medic is inducing a state of exercise in the body, signaling to the buddy that you are going to say exercise, and thus is going improve insulin sensitivity. Is going do all these amazing things. Actually helps people with AFib, believe it or not. So there's studies now that show that it helps, at least in rodent models, that reverses AFIB.

51:13 That could potentially be great for the heart, again, to go back to heart disease. question to it. So that's kind of how I think about it now. What the one thing I'll say for people in that age group, they probably deal with more than other people is chronic aches and pains. And so I, think something like a cartilax, I've heard feedback from people that cartillax has been a game changer, whereas BPC and TB 500 don't necessarily do that much. I. Think if you look at decades of damage done to cartilage soft tissue, especially in the age Yeah, I've heard people say,

51:43 oh, it took VPC and TB 500, and it helped a little bit. What Cardilax is doing is reversing the DNA damage done to the wear and tear on the cartilage tissue. And so it's actually like working at a DNA level to reverse some of that to potentially actually increase the proliferation of cartilage. So I think that's where it is going to be different than some other peptides that don't really have the capability. to do that. But that's how I think about it. I that pretty much covers everything. Do you have anything else for anyone in that age group?

52:15 Was there something about the heart in there? Well, this person is on statins for heart disease. Look, I also think that using TB 500 for cardiovascular health, extremely beneficial. Yeah, there definitely is a lot of data, especially after a cardiac event, that it would help there. All right. Moving over to the next group, this is going to be about perimenopause and GLPs. Very hot topic, especially out in the social media landscape. So we had a few questions around this.

52:45 First one is on semaglutide. They want to know what's genuinely safe to stack with GLP-1. Second, ran Reta for a month and took a months off to avoid losing too much weight and now says it's not working at all. Very common. And she's asking if she desensitized or she just inflamed. Third is 63 post-surgical menopause, has the MTHFR and COMT variants, is borderline diabetic and is down 17 pounds on RETA, but has no energy and needs knee surgery. So the big question is, If you're peri or postmenopausal woman running a GLP one, you are trying to preserve muscle, get your energy back,

53:17 support your joints. What's the actual protocol? And then what peptides can we put alongside of the GLPs when the GOP stops working? Mm hmm. And what do we need to know about desensitization versus dose titration versus taking actual break from red? So to keep that simple, that's what we want to cover in this one. Whip peptide are going to help us preserve muscles alongside Okay. Let's go ahead and let's just put in there that hormone replacement therapy is taken care of.

53:49 Cause I feel, I, feel bad. I always feel like we sound like a broken record with this, but it's true. You're on progesterone, testosterone, possibly estrogen, estrogen. If you need it at that. age group, you probably don't. But let's just say hormone-wise, we're in the clear. We're on all the hormone replacement therapy. we have testosterone. That's going to be a big one to help with muscle gain and muscle protection from losing muscle. So to also stack along with your GLP, I would stack a growth hormone releasing peptide or actual growth hormone, whichever choice you have,

54:30 by stacking in the growth, hormone releasing peptides, such as like an Ipamerelin, CJC, or even a Tessamerelin or MK777, that's going to help act as the aid to helps you build the muscle and also maintain the current muscle that you currently have while you're in your fat loss mode using the GLP. Yeah, I think two to the point of the, the GLP is one hormones and a growth hormone peptide.

55:01 I that solves 90% of that muscle loss equation, assuming the person's eating protein and lifting weights. And then I was also going to add it making sure protein, and this is the biggest thing with women, carbohydrates. Women are scared of carbs. They don't want to eat carbs, you need to be making that you're getting a healthy amount of carbohydrates and protein in, especially when you resistance training and Yeah. So hormone therapy with a GH peptide or HGH with enough protein, with healthy carbohydrates, moderate amounts of fat, healthy fats will solve 95%. I think

55:37 of the loss issue. Yes. Now, the next question there is what about the energy? Because this is, what happens is like this person, they started Reda, lost 17 pounds, but they have no energy whatsoever. And they need knee surgery, which again, I think that probably goes back to, that could just be like a lifestyle thing. But I thing to the, energy piece, this a huge thing because a lot of people get really, really fatigued on Redo. My opinion is one, what we're doing with RETTA is we are literally increasing the amount of calories that we were burning and decreasing the number of

56:10 calorie that were eating. Now, if you were to do that without Rettatruetide, guess what's gonna happen? You're going to get tired because that's called a caloric deficit. The thing with retta is, we don't realize that doing it because we naturally eat less and it's making us burn more calories than we would burn. Like if live the exact same life and you take Rattatrutide you will start to burn probably 200 to 300 more calorie per day than you are. just doing nothing. Then you also reduce probably 200, 300 calories per day. Now all of a sudden you have like for a lot of people a 25 to 40% calorie deficit that off the bat within a month you didn't even try to do anything.

56:46 What do you think is gonna happen if you have 40% or even 25% of less calories going in? You are going to be fatigued. Your body is going have a blowback with that. And so now the question is like, okay, like we said, eat protein, e-carbohydrates and whatever. A lot of times you're going to need some sort of mitochondrial support. Yes. And so that could be SS31. It could MotC. I think with Mot C, some cases that may be too strong. Think that would be to make people even more tired. So I've been seeing that a lot lately.

57:18 I would go with injectable 5-amino. The reason why I'd do that versus an SS31 is that clearly this person is also in, their goal is fat loss right now. So I actually would use the injectible 5 amino to help with the energy levels. Other thing that we also need to touch on too is energy level wise, Thyroid Supplementing with desiccated thyroid that's assuming that already in your protocol with your hormone replacement That's where the hormone-replacement therapy piece comes into play when it comes to energy level is healthy functioning

57:55 thyroid you're on a GLP that is also going to put a little bit of stress on the thyroid because you are going be burning more like what you just said so desicated thyroid being in implated in there. And then we go in with injectable five amino. That's going to help so much with the energy level. Then once they're done with that leaning out cycle and they hit their fat loss goal, that's when I then would introduce the SS 31 rather than introducing

58:26 it while they are in that fat lost mode to kind of repunish that more heavy fatigue that they just went through. Because that is fatigue on the body when you're in a fat-loss mode. Yeah. Five amino would probably be the direct answer to actually just having more energy. Yes. Like I think you're going to get that because it's going raise intracellular NAD also is going enhance fat loss. And then to the point of the red did not work anymore. I Think five amino actually makes your appetite less by itself. It does. So I've noticed, and Taylor definitely has noticed that five amino reduces your appetite to begin with.

59:01 And so I think five-amino would be a really good addition to that. One for the energy, but then that's appetite suppression. Now let's talk about the dose titration. Like, how do you think about dose-titration? Because, okay, this is what's going to happen. People are going start two milligrams of RETTA after a month. They're going be like, wow, I'm losing weight, But I want to lose more. So they're gonna go to four. And then to six and then the eight and all of a sudden there'll be eight or 10 milligrams and it's going to be, you know, 20 to 30 weeks in and be like, I can't lose any more weight.

59:32 Now, if you're doing what we just talked about, which is the hormones, the GH, peptides, five amino, even the SS 31, You're probably going get a lot better results at a lower dose because all those things are going make the RETTA work. better. But let's just say that you are and you're doing that. Now the question is like, what do I do? Do I come off? do i titrate down? I would be of the opinion, Hey, if you were getting to a higher dose of a GLP, don't stop cold turkey. Like I wouldn't bring it down. Yeah.

1:00:02 Like bring it down. Yeah. But like maybe like two milligrams a week until you get down to like one or two kilograms and then come off rather than just stopping at a high dose. Cause I think you're gonna have like a really bad rebound effect. Like I want to manage what's in my body. Well, you want a slowly come out that you can stop it cold turkey. And especially if you were somebody like me who like suffers a lot from food noise, like that can actually, You can reverse all the work you just did. So I would titrate down, then come off of it. And I would come up with it for like four weeks, keep using, you know, injectable five amino during that time.

1:00:37 You could use that during time as well. Um, and that's where you can, this is where like, I think like the biggest piece is that this where adjusting diet and switching up diets can play a big impact in this that a lot of people don't want to do. Yeah, it's easier to take a GLP and just eat however you want. How you feel like eating rather than like conscious of what you're eating.

1:01:07 Yeah. That's kind of my thing is I actually am a fan of like staying on a glp like a large duration of the year. But like right now I'm off of a Glp and I've been off almost a month now. Ironically enough, though, like what I did is I scaled it down. I was like at four to five milligrams a week, and that was as high. And I wanted to push it as I could to see where I can get to, but I couldn't really get much more of that without feeling sick. Now, maybe if I would have like slowly kept, kept going, I'm sure I've could have kept up going up from there.

1:01:37 But I walked it out. So I went from like four milligrams or four and a half milligrams per week down to three and then down the one over like a two week period or two or three week. two week period and then I came completely off and I didn't really notice that much. I really did not notice how much changed my hunger. Now I do know the half because the Half Life is still technically in your system for 30 days because it needs like four to five Half Lives to clear. So I understand it's going to still be in my system 30 years, but even at a one milligram a week dose, it's going to be a very,

1:02:10 very small amount that's in my system relative to how much was in it at one point. And so I like doing that, and I'm going stay off for a month. So you have like a months where you're coming down, a once where completely off, then you can start at a low dose again, build back up. If you do that two times for year, you are basically getting like two months were you like drastically reducing the dose and then two month where your completely And I think that's enough. And then the other times of the year, you can be on a lower dose. You don't have to be a huge dose unless you need to lose fat.

1:02:41 So that would be my recommendation. That keeps you very receptive to it in a low dose, it helps you manage, helps not become dependent on it. And, you know, it's funny is because I had been on Reda for probably like four or five months consecutively, which is the longest I've been before that. And I'm like, man, that's not as bad as you think in your head when you do it. Now I realize like other people may feel that way, but if you manage it that All right, I think we beat that one to death. Last one, this will be it.

1:03:11 Let's talk about some reconstitution. All Right, so we have a lot of questions we always get around reconstition. I'm not going to tell you how much water to mix in your peptide. That's what the peptides cheat sheet is for. And that's with the Peptide Calculator is four. However, one of the biggest questions that we get is what peptids can I mix and the same syringe now? All the ones we talk about, Glow, Cloat, those are all fine to mix in the same syringe. What I like to think of is like, if it's relatively the pathway, it is probably okay. But when we start mixing healing peptides with a GLP or GLPs with the growth hormone peptide or glps with an immunity peptid,

1:03:44 all of a sudden now we're just kind of throwing caution to the wind and hoping that it works. The rule of thumb that I would say is that if you mix it together and it's cloudy, most likely you denature the peptide to now where it is worthless when you inject it. But that doesn't mean that can't be cloudy and that just because it isn't cloudy doesn' t mean it doesn t work. It could potentially still be worthless even if it s not cloudy. And so that's what I do. Outside of those things I just mentioned, which is pathways together, I don't really mix peptides that much.

1:04:18 And if you use pins, it's honestly not that bad to inject. You just get 10 or 15 pins and you can have them all lined out and just do one or two at a time, depending on how many peptide you have. That's what I would say. One of the questions I do get about ARE290, now ARE 290 for me has always worked fine in backwater. However, some people have found that I've talked to that it's beneficial to mix it in phosphate buffered saline solution. So you can get, it is called PBS, phosphate-buffered-saline. You can mix with that instead of back water and that's worked for people that ends up gelling for.

1:04:51 Same thing with acetic acid, sometimes in like AOD or Tessamerelin. If it gels, you can put a little bit of acetyl acid and sometimes that'll break it up. But that's just what I've, don't take that as a gospel. It's what just I have done in practice. I think to the point of combining, that is honestly the best answer I can give you. There's, with 50 different peptides, even just 50 peptide, there is billions if not more combinations that you could use. So there's no way to know like, okay, which ones are going to work together and which it's just use that rule of thumb. If they're in the same family, so to speak, they'll probably okay to mix in same syringe.

1:05:24 You're running an experiment. And so I don't think that it is necessarily dangerous. It's not going to be like a volcano that's going come out of your syringes or whatever, but you could be wasting money, which could a problem. Now, the next part of that question was, Well, the next part of the question was backwater. And so how long is the back water shelf life? I think backwaters are good for at least four to six months after you open it.

1:05:54 A lot of times it'll say 28 or 30 days. I Think it's good four or six, months potentially longer because it does have the preservative, that alcohol in there to keep it preserved. So I personally, I've never had any issues with that. The last part of the question, though, was with nasal sprays. And some people want to know, like, are nasal sprays completely worthless? Because they buy these nasal spays or they make their own nasalspray. Are they completely worthless or are they potentially beneficial in some way? No, I think nasal sprays are very beneficial depending on what you're trying to do.

1:06:24 Like if you are trying heal, you know, a torn road hair cuff, injecting is going to be way better than doing an intranasal BPC. But I thinks when it comes to, especially when comes the cognition peptides, sometimes it is more beneficial to internasally. Anytime you're working with something like the brain, anytime you work with sleep, I think those are super beneficial to use. Yeah, like a GLP, let's be honest, a glp is not going to do anything for you intranasally, that I've seen.

1:06:55 No. But cmax, salang, dihexa, P 21. Some of these can be even KPV. KPB could help with inflammation of the brain. Yeah, for sure. I, it's not going to help. With a knee or maybe the gut, but it definitely could. But a lot of it too, like, you know, if you have candida of that guy, more than likely that can leak into the. Brain, the candita can link into. The brain and using KP. V.

1:07:25 For that, for Kenita the brain to help with the Brain Fog due to gut issues, extremely beneficial. Yeah, absolutely. And so that would be my recommendation is just think about it. Like is this peptide needed in the brain? Then it's probably okay as a nasal spray versus like, you know, is melanotan too going to be good in nasal spraying? Maybe. It's definitely going be a lot better if you inject. Is a GLP going cause you lose fat? If you're doing nasal, spray, maybe. Yeah. Oxytocin is a great, like I use oxytose and internasally and I inject it, um, I think with it being internatally, do get a little bit more of a rapid,

1:07:58 faster relief from anxiety. With it that way. In the brain. But probably not as much the systemic, like muscle building. Muscle building, no. You're not going to get that with your nasal spray. Yeah. And then last part of that was how long do reconstituted peptides usually last? I mean, I've used ones that have been in the fridge for two years and they still work. I know because it's like melanotan or oxytocin where it is a very apparent reaction. Now, is it as potent as the day was mixed? No, of course not. But I will say, realistically, like four to six months, you're going to get like a really good chunk of the peptide working well.

1:08:33 And then after that, it's probably going have some definite degradation, but not so much that it is worthless. So again, there's no hard and fast answer. It depends on the different peptides are going degrade at different rates. But like I said, I've used some peptides that have been in the fridge for two years. Now, why have they been the first for three years? Sometimes it's just, like, oxytocin, and I don't need it all the time until it comes out of my fridge, for 2 years and then I go back and use it or realize that I didn't even have it. I was like oh, i've got this oxy tosine. Sometimes there's like multiple bottles of things reconstituted.

1:09:04 Just because we didn' t realize they were in there in our little box peptide. And I use it and I'm like, oh, wow, there's the flushing within 30 seconds of injecting. And so it does work. But I don't think you have to worry about like oh my goodness, like it's been in the fridge for three months. I've got to throw it away now. Definitely not. Yeah. That would say that for pretty much any peptide. That covers all of our reader mailbag questions. I think this is a pretty good one. We covered a lot of ground. And to me, I always tell you guys, one of the most helpful things you can do for me is to submit these questions because it gives me an understanding of

1:09:37 what people struggle with. As much as I can go read and research and write and make videos all day, having the feedback from you makes me understand what topics need to be covered and how to put them in a format. that is usable and that's the most important thing to us is how do we give you guys a format that it's usable that you can go forth and I always tell people like watch my content and then go make your own life happen so you don't have to watch content anymore unless you for whatever reason just want to be bored. I guess. So, but anyway, thank you guys so much.

1:10:07 As always, remember to submit those questions. And in closing, we're so grateful for you, guys, that support us, whatever form or fashion it is, whether it's being on the email list, using our code in places, being in a private group, or even just sharing this with your friends and family to let them know about peptides that go so far in helping support, us to bring these messages to you. Guys. Again, keep submitting those, questions we love each and every one of you Taylor, anything Thank you guys so much. I appreciate you submitting all of your questions and please keep bringing them in. We love them.

1:10:37 Yep. And we will keep making these as long as you keep submitting them and keep watching. So that's it for this one.