Peptide Q&A · March 2026
Every month I take questions from the submission form and rip through as many as I can. This is the March 2026 batch, organized by category. If you want to send in a question for the next one, the link is always in the podcast description.
GLP-1 Questions
I'm at 15mg tirzepatide and still not at goal weight. Can I stay here indefinitely? How do I switch to retatrutide?
I'd rather not see someone parked at 15mg of tirz forever. If you're not getting where you want at that dose, the question I ask is whether you're hormonally optimized. Are your hormones dialed in? Is your thyroid optimized? A lot of times that's what's actually missing, and people then get better results at a lower peptide dose.
For switching to reta, I'd take about a month to walk the tirz down. Something like 15, 12, 9, 7, 5, then jump to a comparable reta dose. Going from 15mg tirz straight to 15mg reta is too aggressive. Reta is stronger.
Reta shuts down my gut after two doses. Burping, food sitting in my stomach, dry heaving. Any fix?
Honestly, you have to let it clear out. Nausea meds can help, but the real answer is time. For most people it takes three or four days for the symptoms to settle.
I ran reta at 1mg twice a week last year with no issues. Restarted same dose and now I'm nauseous every evening. What changed?
Your sensitivity probably went up. There's evidence we may actually be increasing GLP-1 receptor density on cells with these peptides. So coming off and back on, you can be more sensitive than the first round. Drop the dose. Some people get real ancillary benefits from reta at 100mcg per week. You won't get massive appetite suppression there, but the metabolic benefits are real.
I lost 52lbs on tirz, plateaued, tried reta but my A1C started rising. Went back to tirz and added cagrilintide. Have you seen this combo?
Yes, and it works. Tirz plus cagri is fine. Interesting note on the A1C rise with reta. Glucagon can raise blood sugar. Injectable glucagon is actually used in the diabetic world to bring people out of hypos. The GLP and GIP components of reta usually keep A1C down, but the glucagon piece can push it the other way in some people.
Most people get enough appetite suppression from tirz alone. Cagri is usually layered onto reta when someone needs more.
Why isn't combining tirz and reta dangerous?
There was some meme going around about this. I've personally combined them for months with great results and clean blood work. The logic is simple. Reta is roughly 20% glucagon agonism. If you add tirz on top, you're adding more GLP and adding GIP, which lowers the glucagon proportion to maybe 5 to 10% of the total stack. That reduces hunger for people who get hungry on reta and can also dial back the elevated heart rate some people get.
People claiming it's dangerous aren't showing studies either. Makes good clickbait though.
What about non-responders to GLP-1s?
They exist. I've heard certain genetic phenotypes don't respond, but I can't verify that. What can you do? Cover the bases. Get on hormones. Use a GH peptide. Consider mitochondrial peptides. Cagrilintide can help with appetite. SGLT-2s like Jardiance work really well for some people in this category.
Best stack to maintain or build muscle alongside reta?
Hormones first. Optimized testosterone makes a massive difference regardless of sex. After that, I think about it in categories.
Growth hormone class for the foundation. Growth factors like IGF-1 LR3 and PEG MGF layered on top. Myostatin inhibition if you want to go that route (HJ31, HJ83, follistatin 344), though not everyone needs to. Metabolic modulation with something like an SGLT-2. Injectable oxytocin as a finisher.
For tirz body recomp specifically, a growth hormone peptide is my go-to over MOTS-C or SS-31.
Liver support while on reta?
Reta itself is good for the liver if you're living healthy. To add support, SS-31 is excellent for liver and kidneys. Injectable glutathione, oral TUDCA, and NAC are great. For bioregulators, Ovagen and Livagen are the injectable ones I'd look at.
Reta stacked with 5-amino-1MQ?
I love it. Just ease in. People talking about 10 or 50mg of injectable 5-amino make me cautious. Start at half a milligram to one milligram of injectable and go from there. Too much can spike your heart rate and overstimulate you. I prefer injectable 5-amino over injectable NAD.
GH and Secretagogues
Do you have to refrigerate tesamorelin? I've heard it can gel.
I've never had mine gel in the fridge in all the years I've used it. If your fridge runs cold, sure, it can happen. Honestly most peptides are more stable at room temp than people give them credit for. There's a published study on MOTS-C showing it stays stable for 30 days at around 80-90°F mixed with bac water.
Do I leave my peptides out? No, I refrigerate. But I don't think you're ruining your tesa by leaving it on the counter, especially if it's not hot.
Finishing a 12-week run of tesa, AOD, GLOW, and reta. Should I add ipamorelin now or wait?
Add it now. Ipamorelin is selective in a great way. It doesn't raise prolactin, doesn't raise cortisol, and almost never increases appetite. That's the difference between ipa and the other GHRPs like GHRP-2, GHRP-6, and MK-677. MK-677 is essentially an oral ipamorelin since it's a small molecule. Good option too.
Female, 55+. HGH vs ipa/tesa for longevity?
HGH is going to be better at that age. That doesn't mean ipa and tesa are worthless. Think of it like cars. Nothing wrong with a Toyota 4Runner, but a Ferrari drives differently. A 55-year-old body responds to HGH at the right dose much better than a 30-year-old body responds to a secretagogue.
Female athlete with REDS, no period for two years, eating 3000+ calories. Can GH secretagogues help?
Honestly, probably not for the reproductive piece. If she's burning 5000 and eating 3000, she's still in a 2000-calorie deficit. I ate 6000 calories a day playing football and still lost weight because I was training for hours.
This is going to need hormone replacement. Testosterone and progesterone to get the cycle back. GH secretagogues will help with sleep and have some indirect benefits, but they won't fix the hormonal shutdown. And almost everyone I know who finally pulled the trigger on HRT wishes they'd done it sooner.
Better for belly fat with reta: tesa or CJC-no-DAC with ipa? Should I run SLU, FOX04, epitalon before MOTS-C?
For visceral belly fat, the clinical data favors tesamorelin. Women who are already lean sometimes don't love tesa because it can feel strong, but for someone with real fat to lose, tesa is great.
On the stack before MOTS-C, I'd swap SLU for SS-31. SS-31 with FOX04 and epitalon is more of a healing environment stack. You're cleaning up senescent cells, helping the pituitary through melatonin, supporting telomerase. Then MOTS-C works much better when the foundation is laid.
HGH anti-aging and bone benefits without cancer risk?
I've combed the data and I don't see strong evidence HGH at replacement doses increases cancer risk. One paper I read recently didn't show organ growth until 14 IU in men, and at lower doses there were actually cardioprotective benefits. I'm not telling anyone with active tumors to inject HGH. But for a healthy person at replacement dose, where are all the bodies? I haven't seen them.
Healing and Recovery
Started BPC for ligament tear and developed anhedonia. Already on Wellbutrin. Was BPC the cause?
BPC can affect dopamine regulation. Combined with a dopaminergic drug like Wellbutrin and your own neurochemistry, it's possible. I'd swap BPC for TB-500, cartalax, GHK, or PEG MGF. You'll get the healing without the dopamine downside.
Pre and post-op peptide protocol?
Short answer. Cartalax, BPC, TB-500, GHK, PEG MGF, and add KPV. Run them up to the surgery, stop a couple days before, hold off one or two days after to let inflammation do its job, then resume.
Just had gyno surgery. What to add beyond BPC and TB-500?
Cartalax and PEG MGF. Be careful with injectable GHK near the surgery site. It can burn and make the area more irritated. Use oral or topical GHK on the site if needed.
Nandrolone for chronic forearm tendonitis?
It can work great. I don't think nandrolone is dangerous when used right. But cartalax and PEG MGF can get most people to where they want to be without the systemic side effects.
Metabolic and Nootropic
I have MTHFR and COMT mutations. Could MOTS-C cause methylation problems?
My gut says probably not, but I've been hearing more people get the opposite of the intended effect from MOTS-C lately. They take it for energy and feel more fatigued. My best guess is overspending the mitochondria and building up reactive oxygen species. Similar to what happens when people overdose SLU PP332, even though the mechanisms differ. Worth investigating more in the community.
Methylene blue and 9-Me-BC as nootropics?
9-Me-BC is more of a dopamine-targeted nootropic. Start low, around 5-10mg per day. I don't take it because I don't have noticeable dopamine issues. Methylene blue can be good, but neither would be my first nootropic choice.
Adamax vs Cemax?
Adamax is chemically superior in my view. Same dosing approach. Start around 250mcg and titrate up. Start low with any nootropic because everyone responds differently.
Peptides for hypothalamus and pituitary damage? My daughter had a brain tumor removed.
Hormone replacement therapy is the foundation here regardless of age. I needed testosterone after concussions caused pituitary dysfunction, and my only regret is not starting sooner.
For peptides, look at cortexin (brain bioregulator), epitalon, and there's now a pituitary bioregulator called Endoluten. There are also oral bioregulators specifically for the hypothalamus worth checking out.
Peptides for social anxiety, confidence, fear?
Hormones first. When mine got dialed in, a lot of that stuff just got easier. After that, dihexa, Noopept, and oxytocin can all help. Just remember the chemical piece is only one component. There's a real psychological side to this too. Don't skip working on that part.
Autoimmune
Can thymalin or other peptides help reduce autoimmune disorders like lupus?
Absolutely. I've built specific stacks for autoimmune disease. Everyone's autoimmune presentation is different, but thymalin is where I'd start.
Men's Health
After radical prostatectomy, how do I restore libido using testosterone, estradiol, and DHT?
Removing the prostate kills DHT production. Doctors don't always tell guys that. Injectable DHT is hard to come by these days. Primobolan or Masteron can give you an analogous effect. Proviron at 25-50mg daily might help. Get testosterone dialed in and make sure estradiol is at a healthy level too, because that matters for sex drive. I feel for any guy in that spot.
Early elevated PSA, biopsy showed pre-cancerous cells. Will BPC and TB-500 accelerate cancer growth? I'm 38.
You and your doctor have to make that call together. But if
Full transcript click any paragraph to jump video
Hey everybody, this is Hunter Williams. I hope you're doing amazing wherever you are at today. Today's actually going to be the March 2026 Q&A video. Although I am publishing this, I guess it will be April 3rd, 20, 26. So, if you submitted a question, I'm going to do my best to get through it today. But just as a reminder, If you do want to submit a Question to me, that link will always be in the description of the podcast that I publish. So just look for that. It's got a little link that says Video Topics Submit Request Form, and you can send me a questions that i get to in these Q&As.
A lot of times too, i will send out emails if there are really good ones to to do if they're a good topic. But what I've done today is I have taken these that I got for the last month and then broke them into categories and we're going to rip through those. So before I get into everything, thank you guys so much for your amazing and overwhelming amount of support. The best place to stay in touch with me is on the email list just in case I'm kicked off of any more platforms in the future and all I do on my email is just send out notifications of when I publish videos and then also other things that I'm working on.
And obviously, too, if you want to join my private group, that's called the Axion Collective. We do live coaching calls every Thursday night at 8 p.m. Eastern. If you do want ask me a question, you can privately message me inside there and make sure that your question gets answered. You can have conversations there in the forum or in a private message. So without further ado, I'll jump in and today let's answer some of your questions. The first category we're going to start off with is GLP-1s. Really good one here is to start, I'm in the max dose of TERS at 15 milligrams per week and still not at goal weight.
Can I stay at 50 milligrams indefinitely and how should I switch to RETTA if needed? So it's kind of a tough question to answer that's gonna be different for everyone. My best recommendation for this would be to actually stay on the amount of the peptide that you need to be on until you get to your goal wait. And for some people that might even mean cycling off of peptides and then coming back onto it or continuing through and then maybe upping the dose. Now this person's at 15 milligrams and they're not reaching their goal weight and so this is a lot of times too where I'll look and say hey we might need
to bring something else in. And so to this question I would say, hey are we hormonally optimized? Because if your hormones are optimized and your thyroid is optimized maybe one of those things that you actually get better results at a lower dose. And so I think oftentimes that's probably the best answer. Unfortunately, that is not the one that everyone wants to hear because again, having to go find an HRT doc and do all those thing to get on HRTs and then to the thyroid optimize. But I am not so much of the opinion that have to completely come off the peptide, although I that could be beneficial.
But I do think it's one of those things, like, we don't want to be on a 15-milligram dose of turzapotide every week for the rest of our life. I just don t think that would be beneficial. But, you know, it s up to you and how you decide you want do it. but I would say for a person that wants to switch over to RETTA, my goal for someone that's switching from turze to retta would to take like a one-month period, kind of walk down the turzepotid dose, maybe it is like from 15 to 12 to 9, to eight, to seven, six, five, somewhere in there, and then switch to an appropriate dose of RETTA, which would probably be about the same thing.
But I wouldn't want someone to go from 15 milligrams of TERS to 15 mg of redda, just because I think the red is going to be a lot stronger, in a lotta cases that might not be the best thing for that person. Next question. Rettus shuts down my gut after just two doses a week. Burping, food sitting in my stomach, dry heaving. Is there any fix for this? Unfortunately, for people that have that, really the only fix is to kind of let it get out of your system. And again, this is really relative to dose, but some people can have this happen at a pretty low dose. So I'm sure there's nausea medication that you can take and things like that.
But honestly, It really is only going to happen as the medication clears out of your system. So fortunately, you're kind of stuck with that. Now, fortunately the good part is it usually takes like three or four days for most people to kind have that get out their system Next question, I ran Reta at one milligram twice a week last year with no issues. Restarted six weeks ago at the same dose and now I'm getting nausea almost every evening. What change and should I drop to 250 micrograms as a longevity dose? I'd say for anyone that is getting Naja, the dose is probably too high, meaning that you may have just had more sensitivity to it.
It's not uncommon now that we're seeing that people are actually increasing the number of GLP-1 receptors on their cell from using GLPs. So going off and coming back on, you might be a little bit more sensitive to it than you were the first time, although that's not going to be the case for everyone. But I would say for someone that has restarted it and is more sensitivity to, it you may need to go down on the dose. And again, that could just come from improving your health over the long term. and seeing the benefits of the RETA carryover to where you might not need it. So it's going to be different for everyone. But I would say if you're experiencing nausea and you are doing everything intelligently from a dosing standpoint, it is not the worst thing to drop down
the dose to just get some of those ancillary benefits to which I think there is a lot of people that can get an ancellary benefit of Reta at even 100 micrograms per week. I have seen that and seen people feel good now. Are they going get a ton of appetite suppression, a fat loss? No, but there are still benefits there. Next question, I lost 52 pounds on turzapetide plateaued, tried Reta, but my A1C started rising. Went back to TURZ and added coagulantide. Have you seen this combo used before? Yes I have. I think Turs and coaguilantides is totally fine to use. That's what works for you.
But interestingly around this, glucagon can actually increase blood sugar. If you were to used injectable glucagon, which is different than RETA trutide obviously, Glucogon is actually used in the diabetic world to help people increase their bloodsugar if they go hypo and their blud sugar goes too low. And so I can and have seen this happening with A1C going up. Now, is that the end all be all? No, I think if we get the body to a healthy metabolic state, get rid of the fat and get all the things that we needed in order for that.
RETA can help do that, but it's not uncommon to see that when we're talking about glucagon. I that's where Reta is so powerful because the GLP and the GIP components of RTA are usually enough to keep the the A1C down, but it's definitely possible. But I think to someone, if they don't do well on it, there's no shame in using trisapatite and then throwing coagulantide if you need more appetite suppression. I would say most people get enough appetite depression on trizapatide. It's usually retitrutide that you'll see people add in the coaguilentide, But nonetheless, I, think it is definitely something that,
you could use if it does well for you. Why is combining TURS and RETTA not dangerous? Can you explain why this stack is safer than people think? I guess there was a meme going around or different influencers talking about Turs and Retta being combined being dangerous. I've personally done this for several months at a time and got really good results with it. So if it's dangerous, I didn't see any reason why it would have been dangerous I did see anything in my blood work to reflect that. or anything like that. I guess it makes good clickbait if you talk about combining terms in RETTA. But no, I think it's a perfectly feasible strategy to do.
And the reason that you would do that is you basically are bringing down the proportion of the glucagon agonism. So if the Glucogon aganism, to my best guess, is around like 20% of component of Reta, it is the Gucocon piece. If we introduce terzapotide on top of that, we're getting more GLP and we are getting GIP, and so we now maybe bring down that glucagon from like 20% of the peptide to maybe down to like 5 or 10% percent of peptides. And for a lot of people, one, that's going to reduce the hunger if they're more hungry on retitrutide, but it also, two, could reduce overactivation of nervous system, the increase in heart rate that a lof of ppl struggle with on rtutide.
but you may still want that glucagon piece to help with the energy expenditure of the liver fat. It just might be a little too strong in the ratio that it's in RETTA right now. And so that's why I've seen people do that. But is it dangerous? I mean, we don't have a study to show that that is not dangerous, if that what you want to say, but the people that are saying it is dangerous are not showing a studies to that show it IS dangerous. I have done that before, I worked with tons of people who have. A lot of them get really good results with that now, is that everyone needs to do? Of course not, it isn't dangerous for sure.
What causes some people to be non-responders or slow responders to GLP-1s and what can they do about it? Well, I think when we look at non responders, i haven't verified the truthfulness of this, but I have heard that there are different genetic phenotypes of people that just don't respond to glps, and particularly people of Syrian descent I've heard don' t do well with GLPs. Now that's just something I heard, so take that with a grain of salt. I don t know if that is true or not, And I have seen people that take high doses of GOPs and just do not respond to them whatsoever.
It's definitely few and far between, but I do think those people are out there. What can they do about it? Well, there's lots of other fat loss peptides out. Obviously, we want to cover the bases, right? We want it to be on hormones. We wanted to use a GH peptide. we wanted use mitochondrial peptids.We want make sure that everything in our system is optimized. and then the GLP can be on top of it. But I think if you couldn't, for whatever reason, not have a GLp, that would be unfortunate, or if the glp didn't work for you, it would have been unfortunate. Maybe it's a dose thing that people have to play with.
There's things such as coagulantide that probably would work with appetite suppression. And then there's drugs like SGLT-2s like Jardians that I really think work well for things like that. So it will be few and far between, but I do acknowledge that it is out there. Speaking of Giardiance, someone says, I'm using Giardiants alongside Redif for synergistic effects, but I am not a diabetic. Should I add anything to offset the elevated red blood cell count risk or cycle off regularly? I don't see any issue with this. With Giartiants, you can get a slight elevation in red-blood-cell count, But I've never seen it on my blood work or any other people's bloodwork to where
it was necessarily dangerous. So I would say you don't have to cycle off. If you're gonna cycle-off anything, I will probably cycle of the RETA, that's what I personally do, but I do take Jardience every day and it does seem to work pretty well. What's the best stack to run alongside Reta or other GLP ones to maintain or build muscle? Clo, follow stat, what does the protocol look like with proper diet and training? So if you were going to want to build muscles alongside Reda, you could use a low dose of Rete to really work well for nutrient partitioning.
And although people wouldn't view red as like a muscle building compound at a low dose, I think it does help with nutrient partitioning, but obviously how much you build muscles can be relative to your diet and your training and obviously your hormones too. So the number one stack I would say is to get on hormone therapy because if you have optimized level of testosterone, whether you're a man or a woman, that's going to make a huge difference in the muscle that you going be able to build. Now, on top of that, I kind of like to think about, and this is one thing that we're actually talking about in our group this week when we talk about non-androgen
muscle builders. I like the kind to thing about this, is you have the growth hormone class, so you could have an HGH peptide to build muscle. We have growth factors, we have things like IGF1, LR3, PEG, MGF that can layer in on the top those growth hormones peptides. Then you can get into the the myostatin inhibition question, I don't think that's a path that everyone needs to go down. But sure, you could get into H31 or H83 or follistatin 344 or whatever follestatin is out there. So I think, that is a feasible thing to do. The next thing I would say is like a metabolic modulation.
You could have even something like an SGLT2 to help partition nutrients that I think is going to be beneficial for building muscle and taking oxidative stress off the body during that muscle building phase. And then lastly, you would have something injectable oxytocin. So that's a good thing that you could do, and that would kind of be how I'd think about building that stack. What peptides stack best with trisapatides specifically for body recomp? Kind of the same question, but I would say those that I just answered really stack well with a trizapatide.
And I think if you're going to do one, it would probably be a growth hormone peptide, I'd go to a Growth Hormone Peptide for Body Recomp much more than I will a peptid like MOTC or SS31. RETA and microdosing. Also, what can I add for liver support while on Reto? Well, hopefully if you are just living healthy, the Reta is going to be really good liver-support on its own. I would say things that you could add, SS31 is gonna be very good for the liver and the kidneys, but then injectable glutathione is great for your liver. You can take some oral TUDCA and some in acetylcysteine or NAC.
Those are really great for the liver. And then if you wanted to throw in a bioregulator, you could take, there's two injectable bi oregulators, which I've got dosing guides on and everything on the cheat sheet. One of those being Ovagen and the other being Livagen. So I would check those out. But Retta is great itself for liver and then, if someone is really concerned about liver health, adding those things on top of it should be beneficial. What are your thoughts on Reta stacked with five amino? I think it's amazing. I would just caution people to ease into it.
There's a lot of people out there talking about taking like 10 milligrams or 50 milligrams of injectable five-amino, injectible, not the oral. And while I say do you, because I don't really, it doesn't matter to me what you do, just be cautious with it because it is one of those things, if you take enough five amino you can definitely kind of raise your heart rate and cause this overstimulation. So if you're going to do it, I would start with like half to one milligram of injectable five amino and go from there, but it can work great. I'm a bigger fan, of doing the injectible five Amino than doing injectble NAD.
You can use both of them together, obviously, But I personally just like the Injectible Five Aminos more. That would be my recommendation there. Next one is around, let's go to the next category. So we've got GH secreticogs and growth hormone. Oh man, here's a big one. Do you have to refrigerate tessamerelin? I've heard it can gel if it gets cold. What's the deal? In my life, I have never had tessemereline gel in the refrigerator. However, have seen people that if is really, really cold in their fridge, it congel.
Now there's this whole debate and I really don't want to get into this because this is kind of silly. It's just one of those things that ends up driving lots of engagement on social media. Because if you want. To get views and. I don' do this, but if. You just say stuff that scares people or makes them feel like they're wasting their money and then they'll start fighting in the comments and your stuff gets lots. Of views. And then all of a sudden you're a influencer, right? Well, what's a lot harder to do is sit down and work and talk with real people and answer their questions and really see like what works for people. What doesn't work for Anyway, we talk about refrigerating testosterone.
Look, I don't care if you leave your testosterone at room temperature. Honestly, most peptides, if leave them at temperature, they're probably going to be fine. Much more so than we actually believe. Now, does that mean that I do that? No. I put my peptide in the fridge because I know that's probably what is going keep them stable for the long run. But there's actually a published study on MOTC because there was this big debate on motC over whether or not it degraded within 15 minutes of being mixed with backwater. and they actually mixed it with backwater and left it at a pretty warm temperature.
I want to say like 80 or 90 degrees Fahrenheit, I don't remember, but the Matzi stayed stable for 30 days at warm at temperature and there was like virtually no degradation. So that's Matzzi, it's not Tessamerelin, But do I have to refrigerate Tessemereline? I would say do without wilt. You probably are okay if you leave it out of the fridge, if it is not too hot, and I put it in the refrigerator. But I've never had my gel in my fridge. And if your gel is in your fridge then maybe you want leave out at room temperature, I will, unlike a lot of other people out there, I would never claim to have the definitive answer on things that I can't definitively say yes or no.
I'll tell you, me, Hunter, put my Testimonella in the fridge and I have for years and never had any issues. And so I'm not a chemist. Don't claim be a Chemist, but that's just kind of my thoughts on it. Next question, I'm finishing a 12 week run of Tessa, AOD, Glow, and Retta. Should I add Ipomerelin now or wait until my next Tess cycle? Will the ghrelin bump mess with fat loss when I am this close to my goal? I think you could go ahead and add in Ipromerelin now. And to the point of Ipermerelins with the Ghrelins agonism, because it is a GHRP, which stimulates ghrelin.
The good thing about Iparmereline doing that is it seems to be selective, meaning that it doesn't raise prolactin and it does not raise cortisol. and it doesn't increase appetite. I would say very few people that I have talked to, worked with, heard from, ever really get an increase in appetite from ip and morellum, whereas the other GHRPs you would have MK677 as a GHRP, you would have GHRP2, GHP6. I do see those. Now, MK777 does seem to be like an oral epimerelin because it's a small molecule, not a peptide, but it does seemed to work well.
So I'm a big fan of MK777, But yeah, You could go ahead and add epimerlin. And I don't think the ghrelin bump will mess with that loss at all when you're close to that goal. It definitely won't cause the appetite increase like those other three that I mentioned will. So very common question, I think important to always bring up for women, 55 plus. How does HGH compare to IPA and Tessa as a starting point for longevity? What should a smart stack look like for muscle metabolism, brain health and mitochondrial support? I would say HH, especially for someone that's 55 is always going to be better.
Now, when I say that, a lot of people are like, oh, well, Ipahmorel and Tesmerelin must be worthless. No, they are not worthless by any means. It's just that it's kind of like a car, right? Nothing is wrong with a Toyota forerunner. Toyota Forerunners are great. But if you want a Ferrari, the Ferrari is going to be more expensive and probably drive a little bit better. Although I've never driven a ferrari, probably don't really plan to. I'm not that big of a a person. That's cut. And I like cars. Uh, for whatever reason. I don't say that sanctimoniously, or from a virtue sickling place.
This is not one thing, like I've never been that interested in cars. But to the point, if I'm running a test and running it, fine, but for someone that's 55, the body of a 55-year-old is going to respond at the right dose, probably much, much better than someone in their 30s that probably will respond really good to if they're running their test. So that would be my recommendation there. Can GH secretagogues help a female athlete with REDS whose period has been absent for two years despite eating 3000 plus calories?
Could they help rebalance hormones naturally without the pill? Well, I would say this. I think from the From the reproductive health standpoint for a female, the growth hormone sacretagogues probably are not going to do much to address what is going wrong there with the health, meaning that this person, to me, female athlete, is lots of stress, lots Lots of like hormonal shutdown.
So I think in this case, the main thing that's going to help female athlete like this, assuming they're allowed to do this with their sport is testosterone. They're going need testosterone and they were going any progesterone. get the menstrual cycle back. Those are going to be the biggest things. And obviously eating 3000 calories helps. But if you're burning 5,000 calories a day, well, 3000, calories is still a 2000 calorie deficit. I say that as someone, I used to eat 6,00 calories day when I played football and it sucked. Guess what?
I could still lose weight. eating 6,000 calories because I was practicing for three or four hours a day, training, walking all over the place. You know, when you have a busy day of school and football and things like that. So as someone that comes from this type of background, I get it. And I would say the GH security guys are going to help. Uh, they're going one help a lot with sleep that would probably have an indirect effect on that, but I'd say this pace, unfortunately it's going have to be, and I say that because a of people don't want to have get on this route, this is going gonna have be hormone replacement.
Then once you do go down the hormone Wow. Wow, things are so much better now. Like I wish I would have done this soon. So, um, what's the deal with Tessa Morellen on ovarian health in women? I don't know. I dunno if this person was referencing someone else. Um, I do think Tess Morellin could be beneficial, for ovariant health, although I know specifically if there's research or something around this that showed that they're either not beneficial or they are beneficial. Love to hear more. Let's see, what's better stacked with red up for belly fat, Tessa or CJC, no DAC with IPA?
And should I run SLU, FOX04 and epitalon before starting MOTC? Well, first question first, I would say for Belly Fat specifically, we do have more data around Tessamerelin. Now in this case, it's a woman asking this, so they might do better with CJT, No DAC and IPPA, but I'd say clinically speaking, testosterone is going to be better for getting rid of visceral belly fat. I think women that are leaner don't seem to like testosterone as much because it's so strong and so they feel like they get bloated. But when they need to lose a substantial amount of fat, I thinks testosterone could be great.
And then to the point of SLU, FOX04 and epitalin before starting MRT-C, i think that's a great thing to do. i would do those and maybe even some SS31 Actually, I'd probably take the SS31 with the FOX04 and the epitalon, because to me, that's much more of this kind of like healing environment stack to where we're healing the mitochondria. We're getting rid of senescent cells. Not really healing, but helping the pituitary gland with melatonin. That's going to be an antioxidant, helping with telomerase and things of that nature. So I would say get rid the SLU, bring in SS 31 with FOx04, and epinalon before starting MOTC, cause I think in that case,
the MotC is going work a lot better. How do you get the anti-aging and osteoporosis prevention benefits of HGH without increasing cancer risk? Well, to my knowledge, and I've combed high and low for this, we don't really have any data that says that HCH is increasing in cancer risks. We don't really have any data that show it's growing organs at the right dose. I think I was reading a paper the other day and we didn't see organ growth from HGH until 14 IUs in men.
And actually at a lower dose, there was cardio protective benefits. So to the point of increasing cancer risk, I'm not telling you to inject HTH if you have a bunch of tumors in your body. That would be probably the smartest thing, but I also don' think that someone that's healthy that has a environment in the body that does not favor cancer wouldn't benefit from HEH and could increase their cancer risk. And so it'd be one of those things I'd say like, you know, like let's just think about this a little bit more critically and see what data is out there suggests cancer, risk, and maybe there is that I just haven't seen to which I'm open to looking at, but what date is there out?
There is suggesting more cancer risks. So. That would be my opinion on that is I just haven't seen it in practice. And to that point, it's kind of like, where are the bodies? You know, like where the body's that people are falling like flies from using HGH and having cancer. You could run into other issues, obviously, with HTH and too high of a dose and causing issues with the anabolic steroid abuse. But for a replacement dose, you know we just don't really see it from what I've seen.
Let's move to some got a lot of categories. I'm probably not going to get through all of these. Let's do some healing and injury recovery. I started BPC for hypersitis and a ligament tear and developed anhedonia. Amon Welbutrin daily. Was the B.P.C. the cause? Can I try it again or should I just use TB 500 alone? Well, it is known that Bpc can affect dopamine regulation. Now I don't know what the contraindication would be for someone on an SSR bride like Welputrin, but it might not be well if your dopamine is too low and
serotonin might be high. higher. That could cause anhedonia. I'm not a neuroscientist, but that could potentially be it. So I actually think this is one of those cases where it's like, it might be the peptide or it could be peptides with your unique neurochemistry, with the psychotropic drug that you're combining with it, And in this case, I would say we have TB 500, we Have Carlax, We have GHK, have PEG MGF. And so that would be one of those things that I Would use in replace of the BPC, because I think they're going to be just as good,
but you're not going have the downside of that effect on dopamine, which is interesting. Pre and post-op, peptide, protocol, timing and dosing, how to recover from surgery faster. Just short, shorthand would be cartilax, BPC, TB 500, GHK, PEG, MGF, those five things right there. And then KPV too, I would add in. You get a clove, a club land, cartilax, PEG, MGF. Boom. You run that up into the surgery. I would probably say stop a few days before, and then maybe just one to two days after to kind of let the inflammation come in and do what it needs to
do for the body. And then I will just go right into those after doses, pretty much the standard doses that you would see on those. Just had gyno surgery for recovery beyond BPC and TB 500. What else would you add? Goals to get back to holding my one-year-old ASAP and minimize muscle and fat loss. I would say cartilax, PEG, MGF. And for me, the GHK, if you're injecting the ghk post-surgery, I think it can burn and can actually like make the feeling. Now, If you tolerate it well, you can do fine, or you could do some oral GHk, some topical GH K on the site to help with that.
What are your thoughts on nandrolone for chronic forearm tendonitis? I think it can be great. I thinking nangrolon can great for that. However, I would say there are all these other things like I just talked about with the cartilax and the PGMGF. That will get a lot of people to where they want to be from a feeling standpoint. I think a lot of people use nangirolone because they have joint health issues. And I don't think it's bad for that. Just think that there's easier things that probably have a less systemic side effect than nangerolone would.
Again, and I dont even think nangelone is dangerous if you're using it right, but I just think those other things could be pretty beneficial. This one is kind of around metabolic peptides. Uh, I have both MTHFR and COMT mutations. Matzi seems to interrupt the folate cycle. Could it cause problems for people with methylation? You know, my inclination is to say no. However, I have noticed a lot of people having the opposite intended effect of Matzi lately, meaning that they take Matz for energy and actually makes
them more fatigued. So I would say it's absolutely possible. The thing is, I don't think we really know until obviously it's studied or a person just takes MOTC and they just don t respond well to it. And for that very reason could be the case. Honestly, this is a very, very good question. I think, we could probably investigate deeper and have more people in the community talk about it because I do not know if it is one of those things that you will potentially do that and then have the downside. I think my opinion is a lot of times people that are getting more tired from the MOTC is they're overspending their mitochondria.
They're building up this cascade of reactive oxygen species that build up in the body. And then that will cause these things very similar to how when people overdose or take too much SLU, PP332, obviously there are different mechanisms, but I the same thing is happening with people who are using M.C. I'm interested in Methylene Blue and 9-MeBC as Neutropics, what's your take? I think those could be good. They would not be my first ones to go to. 9 MeBC is more of a NeuTropic for dopamine specifically.
And so you could start at a low dose of like 5 to 10 milligrams of that per day and see how that does. I personally don't feel the need to take that because I don' really have dopamine issues, not that I am aware of. And then methylene blue, you know, methyylene blue can be good. Back when the craze with methylenine blue was going on, I was kind of like, is it worthwhile to take? Is it not? I think it can, but it just wouldn't be my first choice. So I would say that. Is Adamax really superior to CMAX? What's the best dosing protocol for Adamax?
I don't know. Yeah. You know, with the nootropics can just be different for everyone. I think chemically speaking is, is definitely superior to, uh, C max, but I would do the same dosing. Like 250 micrograms to start, see how you do it. And then you can kind of build up from there. But, um, a lot of people go up probably eventually it's like, so, I just say start low with new tropics because someone might not respond the, same as you. So just, be careful with it, not careful, just kind, of know what you're doing. What peptides can help heal damage to the hypothalamus and pituitary gland?
My 22-year-old daughter had a brain tumor removed between the two. She's been cancer-free since 2015, but is endocrine-deficient and on-farm replacements. Well, I'd say that the first thing to that would be, it would crucial for someone that had an issue like that to be on hormone replacement therapy, regardless of your age. And so I'm not a doctor, As someone who has experienced pituitary dysfunction from concussions, I needed testosterone. My only regret with testosterone is that I didn't start it sooner. And so I would say hormone replacement therapy would be very important for that.
But I think from there, we look at something like the hypothetalism of pitutary. You could potentially have a brain bioregulator like cortigen that could help those. I there's also oral bi oregulators now that are made specifically for the hypothalamus that, um, are out there. And I don't, I forget the name of what those are called, but I would check that out. Uh, and then, uh, think someone too, just to kind of help with that epithalon would be good to kinda help, Um, restore brain function. I think cortigen epitalon, if you can find the hypothalamous bioregulator, those could be.
Good. There's a pituitary bi-regulator now called endocrine. So you could check out that one out, the obvious answer for this one is going to be hormone replacement. Are there any peptides that help with social anxiety, confidence, and fear? Yeah, I would absolutely say there are. It's kind of like one of those things. How much time do you have? I'd say hormones first would obviously for me as someone who's dealt with those, hormones made my personality much more enhanced to the point where I didn't really struggle with things as much as, especially like social But I would say, dihexyl can be a really good one.
Nupept can a be really one, oxytocin can really be good. I think those things kind of will help with all those thing. But ultimately, when you look at someone who has anxiety, you know, confidence issues and fear issues, the chemical piece is likely a component of that, but there's also a very real psychological, emotional, mental piece of it. And so, I'm sure, if you're asking this question, and you are probably working on all of those, don't forget that. Talks about some, and it got a few minutes here left.
So let's talk some autoimmune. Can I, can diamond cell for one or any other peptides reduce or eliminate auto immune disorders like lupus? Absolutely. I've done stacks on auto-immune disease, but absolutely. They can, they can help. Obviously everyone's autoimmune is going to be a little bit different, But that would be the first place I would start. All right. Moving along just to finish up. Here's a good one around men's health. After a radical prostatectomy, how do you restore libido using testosterone, estradiol, and DHT?
Removing the prostate kills your DHG production. Doctors don't tell you that. That's unfortunate. You can use injectable DHP, although that might be harder to come by these days. you could also maybe use something like a primobolin or a masturon to give you the analogous effect. Obviously testosterone would be important. And obviously you don' want to make sure estradials are level good too, because that's going to help with sex drive. I think even something like a Proviron, I don't know if it's necessarily going to raise DHT, but it could have like, a similar effect. And so maybe like 25 to 50 milligrams of Proviren a day could be beneficial in that case.
But man, that's, uh, feel for any guy that had that because it is not a fun place to be mentally and emotionally, let alone physically. I might have early elevated PSA biopsy said no cancer, but pre-cancer cells with a cyst on prostate will healing peptides like BPC and TB 500 accelerate cancer cell growth? I'm 38. I think this is like where we have to be like very cautious around what we take as the only opinion from a medical provider.
But early elevated PSA, what does that mean? And I don't know, is it like a 1.8 PSa? What they're saying is elevated. And the biopsy said no cancer, but pre-cancerous cells. Well, I guess every cell would be pre cancerous until it's not, right? If it precancers, and I'm not a physician, so I can't claim to know the distinction between the two. So my opinion would no. But again, you've got to make that decision for yourself with your doctor of what risk are you willing to take to improve yourself? However, if the issue is healing, guess what we can do?
We can use a peptide like Cardilax. We could use peptides like KPV where we don't even have to worry about the quote-unquote risk, and I say quote unquote because it's obviously like risk in theory, we do not have worry those things and we could get as much or even better healing out of those than we would with BPC and TB500. And so that would be my recommendation is to have that conversation, like understand, you know, what's really going on there, get different opinions and whatnot. But, um, I would say, there's other peptides out there that can get you the same goal.
All right. Almost done here. So it looks like we're right at 30 minutes and I'm gonna have to shut it down. What is a really good one that I can go to? to finish it up. In experience with urolithin-A for mitophagy and spermidine for autophage, what dosing levels? Yes, I do. I love both of those compounds. Urolathin A, the capsules are typically like 500 milligrams.
So I would say one to two grams of spermidine, or excuse me, of uralithine A per day. And that'd be like two to four capsuls of most urolythin a brands. And then for spermidine, I like somewhere around like 10 milligrams per day of spermidine. You can go as high as 40 milligrams, but I love both of those. I have great energy when I take those, and I feel really good. And I've used both them and when i've gotten blood work in conjunction, obviously, with other things that I do, the blood works looked really. So I loved both.
They do really well. And I think they're just good things to have in as a background player that we can do all the time, and maybe just go back and forth. You could probably do both of them at the same time. So that's it for today. Thank you guys so much for a wonderful, wonderful month of March 2026. Unfortunately, I wasn't able to get to all of the questions today, but Taylor and I are going to be doing a thing that were working on where instead of doing the lives, we'll continue to do the live Q&As. But in addition to doing those live What we'll do is some reader mail back questions.
So we will sit down with some of the really good questions, probably take an hour or so and go really in depth because I kind of rapid fire through these. And sometimes I'm like, man, I need like 10 minutes to answer this question. I'll be on the lookout for those. But thank you guys so much again. Just in closing, just know that my heart is so grateful that whatever shape or form or fashion that it is that I'm connected with you, that you're out there, just know that. I really appreciate you guys and everything that do to support me. It's dream come true for me to get to do this. And hopefully you receive that back in the content and what you can do with it.
Whether it's liking, sharing, subscribing, telling your friends and family about it, being on the email list, be on a private group, using my codes of places, they go so far in helping me bring you these messages. So that's it for this one and I will talk to you