Peptide Q&A · GLP-1 Peptides, Appetite Hacks, and More

0:09 Hey everybody, this is Hunter Williams. I hope you were doing amazing wherever you are at in the world. Today is another Q and A video. So this one, I'm just going to be going through all of the questions that you guys submitted to the video topic request link down in description of all my videos and just blasting through those and responding to some of your questions. And so I really love these because I love answering questions and it helps make me sharper and sharpen my game. as an educator and someone that just talks about peptides on the internet. And then hopefully this is helpful for you too, because the school of thought I've always had is that if one person is asking the question,

0:45 chances are there's at least 10 or 20 or maybe even a thousand other people that are also asking that question. Um, what I will do is, you know what, for this video, if this one gets 1000 likes, I'll actually take this Q&A video and write it up into a document that I post in the description. So yes, that's right. What I do, is write this up in an FAQ document and then post that down in description, so I didn't even think about that until I started filming this, but I was like, hey, it might actually be helpful for people to have an FQ video. I know I usually say 500, because that will take me a lot more work, A thousand likes will do it.

1:18 But anyway, if it happens, it doesn't, but anyway. I always loved listening to Q and A video on some of my other favorite biohacking podcasts when I was coming up in the game. So hopefully this is helpful to you and everything like that. Um, I'm not going to share my screen with these just cause there are a list of questions that I've copied onto a word document that you wouldn't really be able to see or anything like. That. Um, to get through and, uh, we'll take it from there. So, as always too, don't forget, check out the peptide cheat sheet.

1:50 Uh, that's always down in the link in description and join fully optimized health. That's our amazing, a biohacking community that we have, with Jay Campbell and I and almost 500 other people around the planet right now, bio hacking. Let me pull up my questions and Let's get into it. So someone said, can you do a video of set melanotide for weight loss? So I could. I probably will not though. Set melanitide is basically a melanin receptor peptide.

2:21 And what they did, as far as my understanding goes from reading about it, is they took the appetite suppressing effects that the melanin peptides have. So take, for instance, Melanotan-1, PT-141. Those tend to have a slight appetite-suppressing effect. Now, what they won't tell you is that appetite suppression usually comes because you're nauseous. If you take too much of those peptide, especially Melantan 2, It will suppress your appetite because you're nauseous and you don't feel good and your stomach feels queasy.

2:51 So what they did with set melanotide is that they took that specific function out of that peptide and put it into its own peptides so that it doesn't make you tan and it does not give you the libido boosting effects of PT-141. in Melanotan 1 and Melantan 2, but it does suppress your appetite. Now, like I said, the suppression comes from you being nauseous. So I would not recommend it. And I have heard horror stories from people that took that. If you take even slightly too high of a dose, it can make you extremely nausea.

3:23 like semaglutide gone bad. So I personally would not use it, but hey, I know there's probably people out there because research companies sell it. They'd get results from it but I'm just personally not interested in that. Especially when you have some of the GLPs and some the other peptides that are ancillaries or alternatives to GLP that you can use and mix and cycle on cycle off. I think before it was probably only even a thing because people would use when they were cycling off of a GLp-1. But in my experience, just talking to people out in the field, it's not the best.

3:53 So let's see. The next one is going to be, how can I manage my appetite after stopping a GLP-1 peptide? Any tips for the eight week break? So I do have a lot of tips. I actually just published a video recently called the non-GLP-1 peptides for fat loss. So that would be my first recommendation. Just go to that video. Um, there's lots of other ones out there, but this question was specifically around appetite for, uh, the GLP one. My two big things that I would use are one is testo-fencine.

4:24 And that's not a huge appetite suppressant, it does do enough to suppress appetite more so than just nothing. and my experience. And then also too, um, I like callocurb. So callocurb is a supplement. You can get it from their website or get in on Amazon and it is, a GLP activating supplement, it's actually an herb that activates GLT one. It's not nearly as powerful as something like a turzapetide, But it definitely works and you definitely feel it. So I would check out those two things if you are coming off. And also too, I like to tell people in the GOP1 break, you can actually, if wanted to use it for eight weeks and then spend four weeks titrating down the dose,

5:03 kind of gradually take down appetite suppression to where you still are feeling it, but it doesn't kind stop all at once. So I would do that personally as well. So just titrate down the dose over four weeks to where you're, you know, maybe going from two milligrams during your cycle to one milligram or half a milligram for four and then you come off of it. That way you are not hit with a huge appetite back at once. In my experience, I don't get really hit like a raving appetite when I stop a GLP, but it is a lot better to titrait down.

5:34 in that case. So that's my advice. Next question is using SS 31 before MOTC necessary for best results? So it is not necessary, but I would recommend it. SS31 and MATC are both great peptides and I've talked about before, you can use SS 31 and then use MAT C and will actually work better in doing so, but you could use either one and still get results and also too you use them simultaneously.

6:04 So there's a lot of different protocols. I probably will make a video about, just all the different ones you do with that and Vigorous Steve has a really good video. or series of videos talking about mitochondrial support and stay tuned on that because I've got a lot more coming. Next question is, does switching between GLP-1s affect tolerance? That's a great question. Usually people say that's great questions. They don't know how to respond. That kind of what I'm thinking right now. It does and it doesn't. So like you could go from trisapatite to retitrutide and you'll notice different effects.

6:38 But if you're coming in, so say for instance, you were taking a really high dose, like five to 10 milligrams of trizapatide, and then you went on a low dose of retritrutides, two milligrams. I don't think you're necessarily going to feel anything. It's not going be like taking trisapatite for the first time. Again, if you are substituting with retitrutide. So yes and no. Um, it depends on which GLP ones, cause some are a, you know, single, uh, agonist, a double aganist or a triple agganist. And so it kind of depends the one, but I would say for most part, um, You know you could switch on and off between retritrutite and trizapatide,

7:13 And maybe kind of like get some of the benefits and cycle on cycle off. Um, but in my experience, because it's like a similar pathway, it not necessarily doing the same thing. So the best I can say is try it, um, definitely won't hurt. And I think everyone's going to respond a little bit differently. The next one is, why is tisofensine listed with peptides? Isn't it more like a drug? Well, it actually is a drugs. It is small molecule. Uh, It's actually an S N D R I, which means it's a triple reuptake inhibitor.

7:44 So, um, and helps with the re uptake of serotonin, noradrillin or norepinephrine, whatever you want to call it, or, uh, And also dopamine. so it is drug. The reason is it was an orphan drug, so pharmaceutical companies didn't think it effective enough. to spend the $2 billion on average that it takes to bring a drug to market. And so it just kind of got orphaned and then some research chemical companies found out about it and felt like, hey, this gets good results for people. So they started selling it. It is not a peptide, although it is often lumped in with the research, chemical, companies that sell peptides.

8:16 Good question. Let's see. Next one is going to be, what's the dosage of cerebral liacin in one ample? So don't quote me, but typically, because there's just different people that sell it, it's going be a five ML dose in an ample. And typically that's gonna be one to two doses. So you'll see this ample of cerebral isom usually has five ml, usually retails in the research market somewhere around 20 bucks. So, you can use that one or two times.

8:46 If you wanted to use it multiple times, You'd basically crack open the ample and then withdraw it into multiple syringes. Then you would put those in a fridge or you could use all at once. It is a little bit, harder to inject because it is five mls. So you're, you've got to figure out a way to eject five MLS once, but that is the recommended dosage depending on whatever, uh, issue you are trying to solve for that. I forget if it's cerebral liason.com, if you just look up cerebral liaison protocol, I've one on my channel, um, there is a website,

9:20 of the makers of cerebral isin and they explain the dosing for different reasons you may be looking to use that there. So let's move to the next one. Can I use peptides Alongside semaglutide to boost results. You definitely can use peptides alongside semiglutaride. I actually included this question because I think if you're using semoglutaide right now, you were just messing up. It is relative to what we have access to.

9:52 And I'm not going to go into that right. But relative to what we have access to, I think semaglutide is pretty ineffective just because it's only suppressing appetite as opposed to suppresing appetite and burning fat, which some of the other agonists do. So I know it is cheaper. If you really just need to suppress appetite, you just can't get your appetite under control, it works. But red-headed turds are just so much better. Why is the five days on, two days off cycle so common? Is it necessary? So yes, this does come from the bodybuilding slash bro world of taking something five day on and two day off.

10:29 Typically, I would say it is not necessary, but what it does, especially if you're using a growth hormone peptide is that it allows you to get any water retention off So basically, if you take a growth hormone peptide, you increase growth from on the body, which will tend to lead to water retention, especially around your midsection. What doesn't mean you're getting fat. You just kind of have a thin layer of water. And if your really conscious of your physique, sometimes that can be a little annoying to look in the mirror and be like,

10:59 Hey, I'm not fat, but I've got this water around me. Kind of the same way you would if just flew on a long airplane flight and you get off and your ankles are swollen. And you're retaining a little bit of water in your face and your hands and stuff. So the two days off is to help get rid and flush out some of that water retention. It's also to avoid antibody buildup as fast. Depending on what peptides you are taking, take two day off a week, basically giving yourself a break for two the same sort of rapid buildup that you would

11:31 take if you were taking every day or multiple times a day. So really it's a receptor sensitivity thing to kind of give yourself a chance to where you can run the peptide a little bit longer without worrying about tolerance build up or anything like that. But that's why. Let's see. What are the long-term side effects of memory and learning peptides? Meaning, do you get dumber after stopping them? So you definitely wouldn't get dummer after stoping the peptide. I think the argument could be made that you wouldn' t be as sharp.

12:02 But again, what most of those learning and memory peptidies are doing is helping increase cognitive function. So you're not relying on them per se. They're clearing out inflammation a lot of times, or they're enhancing nerve growth or synaptogenesis in the brain that's going to help you improve your intelligence. So, you might not feel as good or as smart if you are not using them, but I definitely think that you don't go back to baseline meaning that should go to where you were or you where dumber. But hey, I mean everybody is different, everyone takes care of themselves different.

12:33 Um, but I know people are worried about that because they think the same thing. If you take testosterone, do you get lower testosterone? If he stopped, you know, like, and it's like if you drink coffee, are you not as smart when you stop drinking coffee? And it was like well, not really, probably a little bit smarter when we have coffee. You know what I mean? So. Let's see. Someone asked on the learning and memory video about peptides. Can these peptide help with learning physical skills also? Yes, they definitely can. Particularly if you're someone like me, I'm from a background in sports.

13:03 Physical skills require a lot of mental involvement. I would definitely use those if it was something that was huge that you were trying to work on like body coordination or even things like if your job involves a lotta physicality. I definitely can, and they definitely will enhance the nerve growth and neurogenesis around learning any physical skills. So good question. I probably could make a whole other video about that. Let's see. Is there a test to measure natural HGH secretion?

13:33 So there is. It is called a Glucostem test. And most of the time you're going to have to go to a doctor. There's anything that you can order online. But basically it has something to do with like your glucose tolerance or something like that and they can kind of measure your HGH production from there. The reason I know that is because if someone is trying to qualify to get a growth hormone prescription from their doctor, they'll give them that test. And if they fail that task, then they would now qualify for growth hormones. So there is, I think it's kind You can also get your blood work done and look at IGF levels, but as I've talked before, that's very dicey and inconclusive,

14:09 I'll say, as it relates to understanding how much HGH your body is naturally producing. So let's see, someone said, should I taper off it from Maryland or test Maryland? I would say yes, after eight to 12 weeks, you should taper of those. And, uh, I haven't talked about that a lot, but I tend to do that in my own life practice is that, Uh, will taper down the dose of peptides. Um, instead of talking to stop stopping them cold Turkey, um, sometimes I do, and sometimes that tapered down. So it just kind of depends on like what I'm feeling for that specific peptide.

14:40 Next question is, would adding cragrillinatide, otherwise known as CAGRi, help perzapotide work better? So if I'm not mistaken, I believe CAgri is a GIP and a glucagon agonist. No, no, excuse me. Cragrilinotides is an amylin aganist, which is different than the GLP and GIP agonism, but it does help suppress appetite. So it probably would help with your appetite, I just haven't heard like raving reviews about Cagri.

15:11 You probably could, especially if you feel like you're hitting a wall with her appetite to maybe get a little bit more appetite suppression. But just from some of the other things I've talked about in my videos, there's other that I think would be better. They're necessarily adding in that peptide. Next one is, can you mix LL37 and KPB? You can use them concurrently or simultaneously. I would not mix them in the same syringe. The way the Ll37 works, you basically don't want to mix that with any peptides. You're not going to have like in a reaction or anything like that.

15:46 But I believe when you add in other peptides because of the nature of LL37, it tends to denature really bad. So you can use them simultaneously. Just make sure they're not in the same syringe. When you inject them, just do two different injections. Someone said, can CJC1295, ipamrelin, and IGF1LR3 be stacked together? Absolutely. In that case, what I would probably do is use IGf1LR3 in a morning or before a workout. And then I will use CJc slash ipamerlin at night. If I do that, I'm just going to use growth hormone and I'll stack that with IGF-1.

16:17 So I really like stacking IG-F1 with growth form on itself and adhere to the same protocols to IG F1 before cardio or a workout and then the HGH at night. Can you inject different peptides at the time? Yes, you absolutely can for a more in-depth analysis and explanation of that. I've got a video called how to combine multiple peptide in the syringe, so you can do Uh, good question here. Someone says, do you need a PCT after using GH secretagogues? Definitely not. Um, PCP basically means a post cycle therapy, meaning that you would need to recover something that is, uh, been suppressing your natural production like testosterone.

16:57 In the case of GH sacretagogues, those are stimulating your natural production. So ironically, a GH Sacretagogue would actually kind of be post-cycle therapy for growth hormone if you were ever to use growth hormones for a long time and shut down your which I think more or less is a myth, but it's actually like kind of the inverse. So when we think about like testosterone, we use things like HCG and enclomaphene as post-cycle therapy, meaning they help recover our natural testosterone production through the pituitary gland.

17:28 Ironically, the growth hormones or creatagogues are stimulating our natural production of growth hormone, meaning that if we just come off of them, we'll likely just go back to baseline that we were at. But it's a good question because now I think, well, if someone's using HGH and they wanted to come of and their pituitary is shut down, could the GH secretagogue help kind of kickstart natural protection or at least support it in the interim? And I think the answer is yes. So someone says, can you mix Melanotan-1 and oxytocin?

18:00 You know, you could. I haven't mixed them in the same syringe before. Probably wouldn't. Um, I also too, mean I've taken these both together at the time, and it does cause flushing and a redness. Um, so I probably just wouldn't do them at the same time. Um. But I know what people are thinking, cause they both make you feel really good. So you're like, Ooh, I want to double up on the benefit. Uh, but I would probably do on alternate alternating days. If that makes sense. Next question is, should I cycle off TB 500 and BPC 157 for hypertension?

18:35 I would actually use those for hyper tension if you had high blood pressure. So maybe you're in a place, I don't know why this would happen, but if thought that those caused you to increase blood There's probably something else going on. Uh, but I would personally use those for hypertension. Um, you could use them at a really low dose, like a hundred or 200 micrograms per day for a pretty long time without having to worry about cycling off. But you know, when people ask me, should they cycle off of a peptide, it kind of depends on like the worst case scenario.

19:08 If the worst case scenario is you having a heart attack because you have high blood pressure, but the BPC and TB 500 are staving that off, I would say keep taking it and then increase the dose to the point that you can get yourself healthy enough to do it. Because high pressure like I've talked about in a video that I made about it, But if you're just going to treat yourself, um, like a dumpster fire and not do anything about it, uh, that's a bigger issue. So, someone says, how often should I take epitalon for macular degeneration?

19:41 So typically the epitalon would be used in two to three, 10 day cycles per year. I would kind of tell someone like that to say, how much does it help? And some people will see good results with their eyesight from that. And so people won't. So I'd say if it helps you, you could definitely stay on it or do more cycles, maybe even up to five or six cycles a year of that 10 days. But if it doesn't, I don't know that you're necessarily doing anything. Evitalin is a bioregulator, meaning that it brings the organ, the pineal gland back into homeostasis.

20:15 And in doing so, it can help with macular degeneration. But I've heard other people say it does do anything, so it's just really hard to say. Does the amount of water used affect peptide absorption? So the answer is no. That's a good question. As I always say, you can put as much or as little water into the peptides as you want to. You just need to know how much you put in so that you're withdrawing the correct dose. So I actually, I don't know when this video will air, but I do have a free reconstitution, a peptidereconstitution mini course that I'll be publishing

20:50 and I put that in the link of all the videos once it's done. Um, but no, it does not affect the absorption. The only thing I'll say, and this is a little hack for you that I figured out is, uh, with a peptide like GHK that typically comes in like a 50 or 100 milligram vial. Uh, if it's a three milliliter vile, the most you can put most water is three millimeters, meaning that the peptides really concentrated at that dose for

21:20 the amount of milligrams, which means if you inject it, it's going to burn. And that's why most people burn really bad when they inject GHK. I have found that it doesn't completely eradicate the burn, but if I withdraw the dose that I know that i'm using from the vial and then go to my backwater vile and withdraw like 40 more units of back water out of the file, and just kind of swirl the syringe around, What it does is it mitigates the burn and makes it burn less. Now it still stings a little bit. I actually did this the other day because I tweaked my back working out and I was injecting GHK into it.

21:54 And I added a bunch of water to it, like 40 units. It was usually like, it was like a two milligram dose. So it's only like 10 units or whatever. that I had on there and I added a few more units and it burned significantly less and almost non-existently, whereas I know it would have burned a lot more if I was injecting more. So that's a little trick and hack for you. Someone says, is adipotide worth the risk? I would say so. I haven't used it and know you want to be careful, but it's just one that is going to help with cardiovascular endurance if you're looking to increase performance.

22:28 so I don't think the risks are that great. That would need to do more reading. It's One that never really took off because it's not as effective of some of the other peptides I talk about. Someone says, how long can you use copper GHK-CU for pain relief? I'd say as long as you need it. If you're getting good results with it, yeah, typically you want to run a cycle of eight to 12 weeks, but if you have a severe injury or something that needs to be repaired, a traumatic injury, or anything like that, it definitely could be used longer.

22:58 You just want to have to go up the dose. There is the potential for copper toxicity if you're using it for long enough. So I would say probably not more than 16 to 20 weeks just to be on the safe side. But I guess that exists more so than for other peptides like PPC. If you get any good results, I'd say you could use it at least for that long. Next question is, what's the difference between prescription peptides and those available online? Is it worth paying more? Absolutely not. I can't tell you in my public videos where to get peptide, but for the most part, I think there are a lot of times even more pure than some of the pharmaceutical

23:33 peptids I've used and seen before. So, hey, do what thou wilt, But I research is the way to go, especially if you just listen to me and follow what I'm saying. How do SS31, methylene blue, red light therapy and hyperbaric oxygen work together for mitochondrial health? Well, they all do it. I can't sit here and say, and I really wouldn't know in my brain exactly how to categorize all those, but they definitely all work. And I promise you, if you're doing all four of those things, at least on a semi-regular basis, you will have vastly improved mitochondria health than the

24:08 people that you are walking around in public. That is for sure. Next question, how long can you take one IU of HGH if you're over 55? I would say as long as you are alive. I plan on, once I'm over the age of 55, using at least one to two IUs of GH per day for the rest of my life. And again, this is the debate of like, what is natural production? Because after 55 do you really have any natural growth hormone production left? Probably not. So that's really just a replacement dose of human growth hormones.

24:39 I would say after fifty-five, use it as you see fit, but I think you're going to use that for rest your life and be much healthier than people who don't. Does church appetite become more effective again after a break? Absolutely it does. I talk about this all the time and this is why most people in the clinical and mainstream community have it wrong. It's because instead of taking a brake, they will continue to increase the dose once it stops working. So that's just the nature of how peptides work.

25:09 But yes, you can definitely take a break, even if it's just a four-week break or even, if you're titrating down the dose over four weeks and then take two to four week completely off and going back, it definitely will work better because you are resetting your receptor sensitivity to it. Are HEH peptides safe for someone who had the c-word and hopefully you can infer what the C-Word is? In my opinion, yes. I would never tell someone if they have had that they should always use that because each case is different.

25:43 But in my experience, I think the argument could be made that you are better off having a better immune system with the presence of optimized growth hormone levels than without. So I can't say everyone, everyone's different, but that's just my opinion. Do you go back to the same GLP one dose after a break? So yes, I typically do. Um, and obviously I've talked a lot about micro dosing too. So breaking up my dose into, you know, like 0.3 to 0 5 milligrams, uh, two to three times per week.

26:13 My dose is a little less, but I maintain kind of like relatively stable levels over the week instead of kind spiking and crashing. But yeah, You, Uh, would go to same dose. After break. That's the whole point of taking a brake. Good question. You can maybe even go back a little bit lower and then kind of titrate up. So hopefully more people are starting to understand and realize that. Someone says, what should I do if I can't take, it'll be one due to its side effects. Well, I'm sorry. I hate that for you that that's terrible, but the best thing you do, you know, could try Cali-Curb and see if it works.

26:44 But I would also to look at your dose because a lot of people were always taking too high of a dose. And introduce a very small dose, which a lot of times if you're getting from a pharmaceutical company, you can't necessarily do. That's what's great about research. You can start in a really small does and use that first, see how it does, and see if he had any side effects. So that would be my first thing. And also too, he got to look at your diet and lifestyle. Cause if your drinking alcohol, your eating tons of junk food, um, You're going to have GLP one side effect anyway, bad side-effects anyway. Um, I think that is it.

27:18 Let me scroll back up next. I didn't miss any. Yep. That is it. So that is for all of the questions today. Hopefully that was helpful to you guys. And again, if this Q and A video gets a thousand likes, what I will do is I'll write all these up into a document that you can download in the pinned comment and you download that and have for yourself to have as a reference guide. Hey, we'll see if that works. If it's not cool, it lets me know what works and what doesn't work. I appreciate you, guys, Um, as always check out the peptide cheat sheet and sign up for the email list.

27:50 Uh, most people find lots of value in the emails cause send a lot of informative information that I cannot talk about on the YouTube's out there. And, uh, remember to check it out fully up myself. So much love. Um again, don't forget to send your video topic request to that link I have in all my videos so I can get to it on. The next Q and a video and I will talk to you guys in. Peace.