Saturday Morning Coffee Talk · 3/14/26
Good Saturday morning. Taylor and I sat down for our weekly coffee talk and covered a lot of ground. Censorship in the peptide world, allergy season, GLP blends, women's hormones, and a bunch of listener questions. Here's the rundown.
Censorship in the peptide world
I'm not going to throw a pity party. Everyone in peptides gets censored eventually. I'm not unique.
What I'd tell you, whether you're a creator or just someone who follows people in this space, is build an email list. Own something you control instead of relying on platforms.
My Spotify got terminated this week. Thankfully I got it back. The lesson is have everything backed up and keep doing the work at a high level. People who need to find you will find you.
It also looks like more doctors are going to be able to prescribe peptides soon. The research world will still exist, but it may be more fragmented. The best thing we can do is build documented use cases that show people using peptides safely with good outcomes.
Ivermectin horse paste for acne
Jennifer asked about dosing. Small amount on the affected area, gloves on, at night before bed. One tube lasts six or seven applications for me on a bigger area like the shoulder blades. Smaller area, you'll get more uses out of it.
Don't apply before sweating. It's sticky and oily. Most people see clearing within a week.
Taylor's been using a GHK serum and her skin has never looked better, even according to her esthetician. So that's another option for skin texture and clogged pores.
Allergies and pollen
Thymosin alpha 1 is my first peptide pick for allergies. It modulates the immune system, which is what's getting triggered when you react to pollen.
If you've progressed to a sinus infection, that's where LL-37 comes in. KPV can help with inflammation too.
I never had bad allergies growing up, but during spring football practice in college there was construction next to the field. The whole team was blowing out black snot all spring. Brutal.
Adding peptides to Reta for weight loss
If you're on Reta with 50 pounds to lose and want to add something, I'd start with ipamorelin alone. CJC-1295 combined with ipamorelin is a great stack, but a lot of people get a flushing reaction from the CJC that freaks them out.
You can add MOTS-c too, especially if you're feeling fatigued on Reta or need motivation and energy. Just proceed with caution. Reta is already stimulating, MOTS-c is stimulating, and stacking them can redline your nervous system.
If I had to pick one for the long haul, GH peptide over MOTS-c. You'll get more bang for your buck. Better sleep, better recovery.
MK-677 is also worth considering. It's a small molecule, oral, and a lot of people are getting better sleep and likely higher IGF-1 from it than from ipamorelin or CJC.
HGH vs Tesamorelin for fat loss
HGH wins for me. I've been running 4 IUs lately, mostly for fertility, and I'm seeing better fat loss than at 2 IUs.
Tesamorelin is good for specific use cases, but I'd never call it a long-term solution. HGH sits in my foundational hormone bucket.
One thing about Tesamorelin. If you're already lean, most people get water retention, especially at higher doses like 2mg. You can feel like you're regressing even though you're leaning out. Someone at 20% body fat won't notice it as much.
19-year-old daughter with acne, cramps, bloating, sadness
Taylor's take. At 19, progesterone is worth a conversation with a doctor. Days 14-28 of her cycle. It will increase fertility, so be mindful, but plenty of women that age are on it.
Peptide-wise, KPV for acne and inflammation, LL-37 topical or ivermectin horse paste for acne, BPC-157 for inflammation.
Skincare matters. Image Skincare's acne line is great. Clean makeup brushes every two to three weeks. Diet matters too. Limit dairy, fast food, seed oils.
I'd also add metformin at 500mg. It can help clean up candida and any insulin resistance from a not-great teen diet.
For the bloating and cramps specifically, oral peptide gut blends with BPC, TB-500, KPV, and larazotide work well.
The worst thing a doctor will do for this girl is put her on birth control. That'll make it worse, not better.
Bioregulator dosing concerns
No real risk of overdosing on injectable bioregulators like livagen and ovagen. They're amino acid sequences. The body uses them or excretes them.
Bioregulators act more like modulators than sledgehammers. They bring the body into balance. Russian literature has dosed thymalin and similar at 10mg per day intramuscularly for 10 days with no issues.
Livagen is for the liver. Ovagen is for the GI tract, despite the name making people think ovaries. Use them together for liver toxicity.
pH and mixing peptides
For the commonly blended peptides like glow and klow, stability isn't an issue. We have COAs showing 30 days of stability after reconstitution.
Mixing GLPs with growth hormone peptides? I'd stay away from that. Not necessarily a pH issue, but I wouldn't combine them.
With 40-50 commercially available peptides, the combinations are in the trillions. Stick with the blends that are already validated.
Tesamorelin injection site reactions
This is common after a few months. You start building anti-drug antibodies and the immune system kicks up at the injection site.
Options. Benadryl short term. Low-dose naltrexone is my favorite because it modulates the immune system. You can also try thymosin alpha 1 or a microdose GLP, both of which seem to calm the histamine response.
Lupus suggestions
Start basic. BPC-157, TB-500, KPV. From there add thymosin alpha 1. For brain inflammation and tinnitus, cerebrolysin can help.
Lupus is dynamic and complex. Not the same as a torn shoulder. But that's a reasonable starting framework.
HGH timing with Tesamorelin
HGH in the morning, Tesa at night. Tesa pulses the pituitary, which is more in line with circadian rhythm at night.
Weight loss expectations
Unpopular opinion. If you're losing more than 2 pounds a week, there's going to be a consequence. Muscle loss, thyroid suppression, neuroendocrine blowback.
Two pounds a week is 8 pounds a month, 96 pounds a year. That's plenty. Don't push the body into starvation mode.
Reta + Tirz blends
Quick rundown. Reta is roughly 20% glucagon, 50% GIP, 20% GLP-1 in its agonism profile. Tirz is roughly 80% GIP, 20% GLP-1.
Combining them lowers the glucagon ratio. You still get some of the metabolic and liver fat benefits of glucagon without the heart rate spike and nervous system overload some people get from straight Reta.
Reta plus Cagri makes sense if Reta isn't suppressing your appetite enough.
Macular degeneration
A microdose GLP first. Macular degeneration is largely vascular. SS-31 has the most data behind it for this. P21 also has potential. BPC-157 and TB-500 won't hurt either. You can do injections plus eye drops.
SS-31 eye drops
Reconstitute with saline or contact solution, not bacteriostatic water. Bac water burns. Pull it into a dropper, top off with more contact solution. I'd dilute it more than you think. A 10mL bottle works well.
High SHBG and free testosterone
Total testosterone over 1200 but free is low. Proviron at 25mg per day will manually drop SHBG and raise free T.
Before that, look upstream. Toxic load, endocrine disruptors, body fat percentage, inflammation. Boron and zinc are simple starting points. Nobody has a Proviron deficiency.
Pre-workout injectables
My current stack. L-carnitine, DADA, choline, plus aminos like glycine, taurine, arginine, glutamine. I might put together a pre-workout cheat sheet.
Pain level for L-carnitine and choline injections is a 1-3. Glutathione injections are an 8.
Women's testosterone for libido
There's no universal dose. Some women feel best at 5mg, some at 10mg, some at 8mg. The first year is testing.
Frequency matters too. 10mg once weekly causes a much bigger spike than 1.5mg daily subcutaneous. Smoothing out the peaks reduces virilization side effects.
If testosterone is dialed in but libido still isn't there, look at estradiol. Some women don't aromatize enough. A microdose of injectable estradiol, half a milligram to 1mg per week, can help.
Hematocrit on testosterone
Cardio. Smaller, more frequent injections.
I do not recommend women on testosterone donate blood. Most women don't struggle with high hematocrit on T anyway. And the feedback loop testosterone creates in the body means donating blood actually drives iron and ferritin lower than it would for someone not on T.
On peptide testing and COAs
This is going to ruffle feathers. The whole COA marketing thing makes us feel warm and fuzzy, but it's not the full picture.
A batch of 1000 vials, one vial gets tested. How do you know that one vial represents the other 999? You can't test every vial because then you can't sell them.
I know for a fact that multiple companies on Fenrir get their peptides from the same factory in China and have wildly different ratings. A peptide can come off the line at 99.3% purity and test at 98.7% three months later. Doesn't mean it's contaminated. It's lost a little potency from being handled.
It really comes down to trusting your source. I'm all for testing. I'm just saying don't think a single COA proves what's in your specific vial.
My take
A lot of what we covered today comes back to a few simple ideas. Build your foundation with hormones first. Peptides are the decorative pieces, not the structure of the house. Don't push fat loss too aggressively or you'll pay for it. And trust the source you're getting your stuff from, because no test result fully replaces that trust.
Happy Pi Day. Go eat some pie.
Full transcript click any paragraph to jump video
And we're alive. Good Saturday morning, everyone. And well, wait, I know we'll probably have some people coming on here in a second. I did forget to put it in my email. That's okay. It's not an email last night. So hopefully I didn't put on our stories like an hour. Yeah. Think that helps too. Putting it on the Instagram stories. As well.
I've tried to been better. We have a team or team of guys that are helping us now with, um, social media stuff. I'm trying to be better about Instagram. Taylor helps me. Yeah, I haven't been good about it. Like since we weren't on for a little bit, not by choice, but, It's very much like, since we're back on, I don't really check it anymore and get on it
as much. And so therefore I need to start posting more of my stories, but. I'm trying to do a better job. Also too, now that there's people, if you guys could just let us know if we sound okay. Yeah. If we are coming through. Okay. We're still in the infancy of learning our tech set up right now. So I've still always like nervous, like am I going to be talking and can't hear or the video is going be messed up or something. It's okay. My mic's always the issue. I think it's good. It just, with the mics, they're really clear, but you have to talk, like you had to have them kind of close to your mouth.
Cause I know one thing I'm bad at is I'll trail away from the mic. And then I mumble sometimes bad enough and then, uh, I'd trail it away. So, all right. Looks like everyone is saying. Yeah. Jen said it sounded good, okay? Yeah. Hopefully it's, it allowed enough. I have them turned all the way up. So I might just have to talk, talk closer into it. All right. Um, I mean, obviously probably censorship is, but I want to talk about that because that just is kind of like a, I'm not going to throw a pity party.
You know, everyone is getting censored these days. And I think it's just one of those things in a peptide world. Whatever happens in the peptid world, all I'll say about it is I am not unique and then I get censor, you've been censured, and everyone gets censered that talks about peptides. It's, just that I, think for people in pepti world And we're getting there is just to like realize that that is going to be something that we deal with over time. And to have systems set up such as an email list that you can own and control with the people that your in contact with.
And so whether that means you're just someone that follows people in the peptide world, or if you are someone who publishes content in peptides world to be very comfortable with building an email list and building your own thing instead of relying on the platforms. Cause I mean, fortunately we're right now blessed to talking on YouTube and X. But you never know. And it was disheartening for me this week when I woke up or not woke out. It was in the afternoon. Yeah. My Spotify had been completely terminated and that was this heartening, but Hey, I mean, it is where you got it back.
Thankfully. you're on notice now, just make sure that you have everything backed up, which I have all the content backed and stuff, but it's just the fact of what we deal with in the research world. So I'm one of those people, you could either complain about it and say, well, it was me and have a pity party, or you can just do the work and do it at a high level. And I think that's where as much as sometimes you want to have, a pretty party is just, Hey, focus on doing the, and people will find you that need to find.
Yeah. I also think it's interesting. The big thing in the world right now is peptide science has got shut down. It seems like there's gonna be more doctors being able to prescribe peptides. We'll see where that goes from a legislative standpoint. Ultimately, I don't know. I think the research world is going to exist. That may be much more fragmented in future. Whereas in last two years, you've seen a lot of companies really been able scale and serve the market pretty efficiently because they essentially created the great market when they told a lotta clinicians that they couldn't.
prescribed or they didn't tell clinicians, they told compounding pharmacies that they could no longer make peptides. They were category two or whatnot. And so, here we are and it looks like there's going to be more doctors prescribe me. I think the research world is always going exist. And it's just one of those things. Again, we just have to, We can't complain about it. We just to do what we do. think for us, if anything, the best thing, and this is one thing I'm working on, I know other people are too, is to get validity around peptide use and
build systems that show, Hey, have documented use cases of people using peptides and nothing bad is happening. and actually quite the contrary, good things are happening. I think if anything, you could complain about it. You go to Congress, You write your congressman, and you can do all that stuff. And I'm not one to think that that's ever really going to do anything because that machine rolls on. But it's going be one of those things, if we can show people that this is normal and acclimate people to understanding that is okay and we have use cases
of people who have done this and they've done it well. At least what we could control and build out. Yeah. I don't know. What do you, any topics for the week you've seen this week thought about anything on your mind? No, no. Yeah, I wouldn't say there was anything topically. Topic wise. This week went by like really quick.
But no, I feel like topic wise, it's been a quiet week. But I've also just been in editing mode all week, so I have been introverted. Mercury in retrograde. Well, and then Jupiter went direct. I don't really know what that means. I sure as heck doesn't, don't know what it means, but I've heard other people say that. And when you're, if your life is crazy and like look it up, I just haven't had, and if you like this crazy, then you can say,
well, Mercury's in retrograde. Mercury is always in great though. Well, it probably is multiple times per year. Maybe. Yeah. I don' know. Well, without any further topical rants that we can do, let's just start going into some questions. So Jennifer says, first off, thank you for your time and work. Last time you mentioned Ivermectin horse paste. Would that be every day in AM small amount on the finger? My son is taking LL 37 and BPC as of now. Yeah.
I would say wherever the affected area is just, it does not have to be a ton. For me, one of those tubes, if I get a horse pace tube, It'll last. probably six or seven times, but that's covering a bigger swath of area on my shoulder blades and everything. But if it's a smaller area, you definitely can use it. Definitely use gloves when you put it on. It can be kind of sticky. Yeah, it can be kind of sticky and oily. And so you definitely don't want to do it before you're going to be sweating or anything.
I would probably say. No, I think doing it at night at bedtime, like at those, your bedtime skincare routine, that's the best time to apply it. Yeah. Especially, especially if it's like a, for a teenager. Cause I know I'm not gonna sweat. So that's what I would do. I don't think it really matters for the effectiveness for Yeah. I would say I prefer to do it at night, but I will do every day and you'll probably notice within a week or so, it'll start to clear up.
Yeah, I'd be interested because I haven't tried this for specifically acne. If you took oral ivermectin, if that would help, the topical does seem to help though. The GHK serum that I've talked about in my emails, like I feel like that GH K serum has like helped my acne, a lot, but like I don't have like every, there's so many different types of acne. Um, some, my acne is more like the, the common don' acne where it doesn't like a surface.
It's like, uh, cause the oil is so thick. The pores are clogged where It just looks raised. There's like no blackhead, there's no like whitehead. It's just like a, like, a raised clogged pore. And I feel like that's helped me a lot. But I think if someone has, is having more cystic acne, I mean, it's better for them. Yeah. I don't know. My skin looks really good. Even like my esthetician that I go to, she even said, this is the best I've ever seen your skin look.
And that's the only thing different. Specifically on your face? Yes. Yeah. I'd say the skin on her back is actually very clear. Not that it wasn't clear before. It's more smooth. It is more smooth. I think also like, which I, I'm using like the certain GH is like helping a lot too. Yeah. Also like I now, now that we're talking and my brain's a little bit more firing, like allergies, pollen, people have been asking peptides for pollen and allergies.
That's the one I would be my first. First, just because it modulates the immune system, typically allergies. is triggering your immune system. And that's why we have all these responses, but we were outside this, we're outside. This morning in my, I came back inside and my eyes were super itchy. There's already some pollen and everything out in the air. But that myself for one can be really good for that. I don't think you need LL 37 specifically for allergies. If you have like a sinus infection going on from allergies and from pollen, like especially like if you're in The South and like the pine pollen starts,
That's when a lot of people can kind of start getting more like sinus infections from the pine pollen. Yeah. I think it wouldn't get to the point of being a sinus infection. Infection, that's what I'd think, LL-37. Wouldn't it bring in L-L37? Yeah, KPV can help modulate inflammation as well, but I thin thymus and alpha 1 would be my go-to just for allergy season to help with that. But I've been fortunate in my life, I never really had bad allergies. There was one time in college though, during spring football practice where they were doing construction next to the practice field and everyone on the
team was blowing out black snot for the entire spring. It was really bad. I was like, did I just want your, I want to say it was 2012 or 2013. Well, what like was that like your freshmen? I think it's my sophomore year. Yeah. Yeah. Cause just like shifting locations, even though that's not that far away from where you grew up, like just shifting the locations to like different, there were different pollens in that area of North Carolina that could have triggered you differently too.
Well, that was more so the construction. Yeah, That's what sucks is the. Construction was really tough. Because it was black. It wasn't just runny nose and irritated eyes. I do think the eye drops, potentially if you use BPC and TP 500 eye drop for people to get really bad eyes, that could probably help if. If you have issues with the eyes. I think it was regular. Probably regular eye-drops better. Cause it's more so you're having to flush, flush out the ice and you don't want to use those drops. Yeah.
Next question. I'm on Reda with about 50 pounds still to lose. Do you want to put the questions? Oh yeah. Sorry. Always forget that guys. Apologize. It's because you can't do it like when we're on our live calls for the, for group. So I think that's like, it's just, this is the only time cause we were in stream yard. Yeah. Um, I read a true tie with, about £50 still lose, would you recommend adding Ipermelon or Matzi and why, and if Ipermelon should be used alone or with CJC one, two, nine, five Taylor. So I think definitely you should be using or I shouldn't, let me rework that.
If it were me, I would be a growth hormone releasing peptide. Um, I would start with just ipamerelin. I think ipamarilin and CJC combined is a great combo. Personally, I like doing that, but a lot of people get a flushing reaction from the CJZ. So I say start cause increase at heart rate, and that can kind of freak people out when they get that.
And I would say like, I hear that feedback more times than none. Personally, like that flushing warming sensation, because in my mind, it's like oh, i feel like it s doing something. But that ca turn a lot of people off from it. So I'd say just start with Ipameralin, see how you do with that if you know, depending on like you know, if you wanted to add the MOTC in, you totally can. If you're needing to get that much weight off, I personally, like to use Motsy when I'm not on literature time, but now that like,
we do read it differently now where we really like stay on Reda for like until you reach the weight loss goal. You definitely could add that in especially if are needing more motivation to like the energy levels going. And some people get fatigued when they're on Retta. So I definitely, I think using it can be great. I think you could do both of them, meaning that you can do IPA with Matzi. I don't see pathway-wise anything wrong with that. No. The one caveat being that when you have RETA and it's very stimulating to people, to their nervous system, Matz can be extra stimulating,
and then you almost redline yourself. So I would just say proceed with caution if you're going to do that, but if I could only pick one, for the long haul, I think you'll get more bang for your buck out of a GH peptide than Matzi. Yeah, absolutely. Just for that long hall, you're going to sleep better. Oh, they were asking, adding Yipa or Matzzi? Okay. I Yeah. If we're saying like one or the other, I would definitely pick the IPA, not the Matzi. Yeah, sorry. One thing too, i'm not trying to push this because I don't make money off.
Obviously I have codes of places. It seems like the more and more people that use MK777, that seems to be a very good alternative to ipamerelin. Meaning it's a small molecule agonist. You don' have to inject it as a capsule. It's a capsule or a powder or tincture. And you can do that. I've just heard a lot of really good things. People are probably getting better sleep out of that than they do Hippomerelin or CJC. Yeah. and I would bet my bottom dollar that their IGF is going higher off MK777 than it is from Hiippomerelin.
Not that it wouldn't increase with Hiipomerealin or Hippa and CJ. But yeah, that's another one too that is a good alternative. for people. What's interesting now is if you really wanted to, you could use a GLP and a GH, basically a G-H agonist, and you wouldn't have to use an injection. You could do Orforcal Epron in MK777 and SLU for mitochondrial health. And you can kind of get that GLp, fat loss, appetite suppression, the mitochondria with the SLu oral capsules, growth hormone with the MK777.
Do you think now with all the changes that are possibly going to be coming with peptides, do you that we'll start seeing even more people using the small molecule capsules? Cause like right for, or for Glepon in general, in the research world, if that shift does happen, I don't know, because if they do, it just is whack-a-mole.
More people do this, they'll try to shut this down. So I dunno. It's a good question. I hope not. I would just, why can't people just put what they want to on their own bodies? It seems like a very simple concept. If I can go to a store and buy enough alcohol to kill myself. It always goes back to. to control. Whatever it is, it's always about control, control and how power and money. But the money is for control so it was just an abominable snowman avalanche of control of money and power.
Interesting. Yeah. It's funny with Taylor and I were actually talking about this morning is you have the big pharma companies that go after the compounding pharmacies, but then the Compounding Pharmacy say the research companies are the bad guys and it all just because they're trying to protect their turf. You're, this is my turf. You can't have it. This is much or if you can have everyone just kind of points a finger and says, no, they're the ones that are bad. And it's for the sake of my, I don't, have a problem with any of them actually. Yeah. If you want to get triseptide for me, like Lily, go ahead. That's perfectly fine. In some cases, we, you know, at least for a fact, for most part, it was going to be clean.
So if, if want pay $750 a month or whatever it is now to give it from them, Go ahead, but then there's people that have had bad reactions from peptides from compounding. But then yes, the compounding pharmacies are not immune, no pun intended, to having bad reactions for people. There's sterility issues with compounding pharmacies as much as there is the research. Yeah. Isn't it crazy? Like just think about like how just money, just like it's like, it just rules everything.
Well, I don't say that as someone. No, not saying that. Hippie in the hippie sense. But yeah, what we were talking about is what's the difference between 80 million and 100 million for someone? Yeah, practically speaking. It's just psychological control. I guess. Yeah. But I don't know. So. It's kind of gross when you think about it. Although it's like, yes, we all. Need money to like. Yeah, you gotta have money. You gotta. Have money, but it still just like crazy. Just how much like something can have so much power.
Well, when. When you go up to the top levels of how it really is like allocation of power to dictate what people can and can't do. Jim says, what HGH work better than Tessa for fat loss? I am HO. Yes. I would say yes. I've been using four IUs of HGH lately, mainly for fertility purposes. But even going from two to four, I use, because I normally do two Ius to go to a four. I feel like there's greater fat loss given GLP use and given everything else I'm doing.
I don't think I like that much. Yeah, it's, I just like, the amount of water retention I get with it. It is what it is. I would never say, Tessamerelin is a long-term solution where HEH to me is in the bucket of my foundational hormone replacement. And I think you can use TESSAMERELIN for very specific use cases to create an effect. But again, comparing it to HTH, I just think HHH is always going to be better.
But I would not tell people not to try Tessamerelin. I've used Tessa more than as much as anyone in the past. And I will just always go back to the HGH. Yeah. This is not the case for everyone. That I don't say this in a sanctimonious way. With Tessemorelin, if you're already relatively lean, Most people get water retention, and especially if you're doing a higher dose, like two milligrams per day, most people will get Water retention. And even though you are leaning out, you retaining water, which will go away in three to four days after stopping it, but it can feel like you regressing,
in a sense, because you have water attention, even thought you leaning it out. Whereas someone that maybe is 20% body fat, like if a man's 20%, body fap, he's not going to really notice that layer of water retention. Cause he already has a little bit from being a higher percent body, fat to which he will see more results from the test of morelin. Whereas if you're 8%, bodyfat and you were trying to use it to go to 6% or 10% trying test them around, like the water retention to me is more pronounced.
And so I get up two weeks after taking them. I feel as if I look like a water balloon. And I'm not, but it just is because of that. Whereas with, if you have good GH, for I use of HGH, I don't really retain any water on that, not to say that someone wouldn't, But for me, am accustomed to using it. I've built up to that over time and I won't get any more water retention and it helps me with fat loss. My personal opinion would be that yes, it's better.
But it is not that Tessa Morellen doesn't help with that loss, There's lots of anecdotal and clinical data. I think women much more so would probably notice the water retention than a man would. Let's see. Thank you, Jim. I do my best with emails to not have something that would be spam. And when I talk about the email list, it's really to be able to have a relationship with you guys.
What I did with my emails is I'm constantly working on researching and putting together content, and I either use that to say, hey, here's some new content or this is what I am working or I came across. Here's something I shared with. To me, that's one of the funnest things I get to do is to write emails because I know that it helps people. And amongst, I think people get 50, on average, like 50 emails an hour or something crazy when you look at all the different marketing and promotion stuff.
They actually have one, a nugget in there that is worthwhile. I don't know, obviously it's not for everyone, but thank you for that. Just stay in contact with us again. Emails are the best place. Here's a good question for Taylor. I'll read it for you. Taylor, my daughter's 19 struggles with acne, cramps, sadness, bloating. Do you have any suggestions on what she can do to help her when this happens for that? So I would suggest at that age, looking into meeting with a doctor for progesterone because pro gesterones can definitely help.
It will increase fertility so that's something to be mindful with but pro-gesteron at that age I know women that definitely go on at that age. So I would definitely suggest progesterone during day 14 through 28 of her cycle. If you don't want to go down that route, my suggestions would be It's like a hard one, peptide wise. I mean, you could try like BBC to help with inflammation, KPV.
KPB would be a great one because it's also going to with the acne, also gonna help inflammation. You can do the LL37, that's gonna that can help with acne, ivermectin horse pace, that's going to help the acne. I would suggest following up with a good skincare regimen. That's a tough age. For most people, it's tough to get into a routine with skincare habits, especially for girls, like cleaning makeup brushes at least every three weeks.
At least like that sounds tedious, but like makeup brush cleaning, it makes a huge difference on your skin. Even if you did it like technically you should do it, like at least once a week, But atleast like two to three times, you know, every two or three weeks, clean your makeup brushes and then skincare regimens would be, cleanse, tone, moisturize, and some type of acne based treatment. Um, even at that age, I would say image skincare has been my favorite line, their acne line.
For acne, the entire line is great. That would be my go-to, because that's going to make a difference. And then diet is also going make difference too. It's a tough age with diet, so I'd say limit the amount of dairy. that she's intaking. If she is doing a lot of dairy, that makes a difference. Fast food, seed oils, those make a different. It's a tough age. But it's also kind of widespread there.
That would be my suggestion. Yeah. I think when it comes to the acne and the bloating, obviously that's, there's a hormonal component of that. But I think too, a lot of those oral peptide gut blends with BPC, TP 500, KKB, lorazetide, I'll think those will help a lots too. And I'm sure she's probably pretty proactive, but it's hard as a 19 year old to have How many 19-year-olds are really going to have a clean diet?
I know I sure did. No, I didn't at 19. I ate whatever and whatever I could get at nineteen. Obviously, that was an athlete. So I was just doing it. And so I think even just those oral peptide blends will help and make sure it's one with lorazetide because I Obviously there's probably a hormonal component to it. I think the progesterone could potentially help with that and the cramps.
And then I would go from there and see what happens. Definitely don't think it's one of those things. We, this is another, another large cross section of America that you see this age group of women really left to dry. Would you say. Meaning from their doctor, sorry, I'll let you, but just meaning from the pharma world, how they treat them. Because typically I would imagine if a girl like this goes to the doctor- They're going to put her on birth control and that's the worst thing that you
can do. Which will maybe be a band-aid to problem. No, it's going make it worse. Well, yeah. Meaning that it would just get infected, not infected. But it will just continue to fester if put on birth control. Yeah. I mean, even when I was on Birth Control, I still had acne issues. Sorry. What were we going to say? I cut you off. Um, it was also going maybe to add maybe in there, um, metformin. yeah, don't think that would be bad. There's one diet's going be a little off, so it's gonna clean out any candida, any like insulin resistance that's on from the diet too.
Yeah. Just clean up inflammation. It doesn't have to be a lot. 500 milligrams I think would be really good. Yeah, great question. Those are such good questions because that, when I of that I, think how many millions of girls out there have that right now. And it probably doesn' have be as bad as it is. But I also think about this, it's like those Asian group of people aren't watching our stuff, which would b really beneficial. Their parents are.
Would you have watched you now at 19? Maybe, because I've always been into health, so. I was watching Joe Rogan. When I 19, I found Joe, me and my roommates found, Joe Rogen. And he had like 20,000 subscribers on YouTube. Yeah. He was talking about aliens. That gives you the extent of what I. Was watching when I, when was 19 I watching, like, uh, was like starting my career in the hair industry. So like I just watching like hair and makeup, tutorials to help with that.
So maybe not the extent to which I cared about health only related to my job as a football player. Yeah. I also didn't like, yeah, I didn' really have a laptop at that age. Like I really did. It was also a different time. Different time, like I I don't even think iPads didn't have an iPad. No, like I didn' have a laptop at that age. Like I think I did, but like, I, didn, do like. I. Didn't do anything with the internet. Cause that's not what my, at.
That point, that. Not what the, when my industry was about, and I'd have to worry about business stuff at, because I was working in salons that took care of a lot of that, yeah. you ever think we'll look back 30 years from now? I'd be like back in my day, I had to search for stuff and chat GPT to whatever they're going to have then. I don't know. That's kind of scary to think what will be out then? Yeah. Are there side effects if you take too high a dose of bioregulators currently using a livagen and ovagen?
Not that I would know of. I mean, there are every possibility exists with livagen and ovagen, specifically we're doing the injectable ones. If you took the whole bottle, I've never even seen people that do higher doses, 10 milligrams, 20 milligrams that have had anything bad happen. And the reason is, is one, they're just amino acids. So they've, the body uses them, breaks it down. It just excretes it as waste, meaning that it's not a pharmaceutical drug that has the signaling molecules or even like another peptide.
such as GLP that would have very different metabolization in the body versus livagen and ovagen, I don't think there would be. And also too, they work more. We have some peptides that exist on the spectrum of as signalers, and they can act as a sledgehammer, meaning that the higher the dose, stronger and stronger are stronger than stronger the signal gets. Whereas other peptide seem to act more like modulators, And they bring you in balance and almost regardless of the dose,
it's not going to have effects beyond that other than you just not having anything happen. And I think the bioregulators are much more like that. Obviously, this is me speaking from anecdotal user experience, much than the chemical side of things, but that's what I seem to notice. And when you look at a lot of the bio-regulators, I don't know specifically with livagen and ovagen, maybe ovogen, sometimes the dosing is 10 milligrams intramuscularly per day for 10 days in Russian literature. I know, specifically, testagen is that, I don't know which other ones.
I think thymalin would be similar. The dosing, a lot of times we'll go up to 10 milligrams per day injected. You gave me over. Did you give me a virgin? No, over gen is actually not for ovaries. Most people think that overgen is for the ovary. It's actually for. And it does have some GI, some stomach benefits. Same thing with libogen. Libogen is four the liver. Ovagen would be more of a crossover, had some liver benefits, has some stomach benefits and then livagen is for the liver. But if you were trying to heal your liver, you would use, could use both of them together.
And I know they have been used specifically for people that have liver toxicity issues. If I'm quoting off of memory, right? Don't hold me to this. I am pretty sure in certain countries they had been use as adjuncts to chemotherapy to help with liver toxins. and things of that nature. I know thymalin has, or I want to say, but if I've read too much that sometimes it gets conflated, I do think that. But I don't think there's anything wrong with taking too high of a dose of those.
What I have given you that you didn't really like was xenolutin, and that's the oral bioregulator for the ovaries. And obviously fertility is our main goal right now. It was too much. But I'm also on, I am on therapeutic testosterone. So I think it was. Yeah. You could have just had a response where the estrogen maybe was to high and you had, had that because you aromatized your testosterone really well into estrogen. Let's see. What is your opinion on pH difference and significantly influences stability, solubility, and activity of mixed peptides?
I think when we look at the typical peptide that come into blends, I don't see any issues with stability. And we have multiple documented COAs and tests done on these blends to show that even after 30 days of being mixed in bacteriostatic water, that they're still stable. Hopefully this myth will go to die. Now, does that mean that you couldn't mix I would probably stay away from doing that.
And I don't know that that's necessarily a pH issue, but there could potentially be something wrong when you mix those together, predominantly sold commercially. We don't seem to see any pH issues. I think the largest would be the glow and the clow because those are so popular. They work so well for people. And obviously if you could do three in one or four in, one who, who doesn't want to, yeah. Right. So I would say I don' see issues predominantly with the ones that we were talking about.
Obviously I want people to remember too, when you ask questions about mixing peptides for me, I, I want to always do my best to answer questions, but when you talk about mixing peptides, if you have 40 to 50 commercially available research peptide, and you're talking about missing those, the amount of combinations is probably in the trillions of what you can mix together. And it's hard to say, okay, you could mix this with this, mix with that. But in terms of the pH question, I think it is more for the ones that we know that are blended together, Most of the time it's always going to be okay.
Yeah. Just going through. Thank you guys for the love. Thoughts on GC1-sebederome, I think is how you pronounce it. For fat loss, recently came across this peptide. I was curious about your experience and your knowledge of it." GC-1 is actually, forget it, don't think it's a peptides, but it basically is working on the thyroid.
And I don't know too much about it and I've never personally used it. I think for people attempting to lose weight, if they could not get desiccated thyroid, I see, from what I have read about, it, more benefits from that than using synthetic T3 or T4. Yeah. And then from there you could go to GC1, but my default is always going to be desiccated thyroid.
Yeah, But if you couldn't get desicated thyroid for any reason, I don't think GC one is to me as good as desicate thyroid, it will probably be better than nothing. Especially if your losing weight and want something to help support a thyroid I think it's probably the bias. So you still think the thyroid by regulator would be. would be your second choice. I would do that. First, run a cycle. Yeah. Before using the GC one. And then after that I'd go to that, but I don't think it's bad. No evidence to suggest it is bad, I have to look up the dosing off hand.
If I didn't have desiccated thyroid, it might be something I'll be using. It's even more mild than desicated thyroid from a strength standpoint. But it seems like it could be good. It's a good topic to go deep on. Maybe I'll get some and play around with it. Is it okay to inject the Wolverine stack directly into one of my quad muscles that I injured? Sure, if you can tolerate because it probably is going to sting. But yes, I would say just a shallow IM injection would be totally fine, especially if it's quad muscle to do.
My 20 year old daughter has mono. What advice would you give to treat the swollen lymph nodes and fatigue? If I miss an awful one, I would definitely do. I wouldn't even do either like BPC or TB 500 blend in there just to help with the inflammation. Would you consider LL 37 for that? Would be my question for you. Probably do it. Yeah. Cause mono is an infection, right? Yes.
But it's like a long, like, a lot of times people get mono. It's a very long process to get over. Here's what I think would not, here's, what, I would think, would, not hurt BPC, TB, KPB, thymus and alpha one all 37. I don't think that's going to hurt if anything, it's gonna make it better and probably help, help the immune system get to the point where it helping bring down the inflammation with the swollen lymph nodes and helping get whatever's out there. And I, and I give that a shot.
Why that would cause any harm. Not saying it was going solve everything, but, That would be my suggestion. My 62 year old 105 pound wife has been taking Tessamerelin for several months with great success. 40 units, five days on, two days off. She gets an itchy bump at the injection site that lasts for three to four days. Concerns. I'd say it's not a concern. Typically what happens though, this is actually, I see this more with Tesamerelin that people will use it fine for a few months. And then all of a sudden they start having, developing an allergy.
And in my opinion, this is not something that is a quality concern of the peptide itself. It is the body's response to where that's right about this time, several months to like where you will start to build up anti-drug antibodies to it. And sometimes that can lead the immune system to begin to create that. Now you could try Benadryl short-term to do it, you could try low dose naltrexone. I think low-dose naltrexon would be good because that modulates the immune system. Plus at that age too. Yeah, I just think it's good to have in general, and it does seem to modulate the response that most people get to peptides.
In a lot of cases though, let's say every case. The reason I say that is because every time I said something, someone will say, Nope, I'm doing that and it didn't work for me. And I know that it's not going to work in all cases, but in the majority of cases loadless nitroxone does seem to help. Yeah. From there, you could even potentially use the thymus and alpha one, a microdose of a GLP. to help because that does seem to the histamine response or the MCAS response that people are having. But no, I wouldn't say concern other than it's obviously uncomfortable and it is not fine, but there are options and that would be kind of the hierarchy
that I would go down. Sometimes if you just take a Benadryl, it will knock it out. Or if take it right before, you dose the Tessameralin. It could help. The TV is so distracting for me because it s the picture TV. This is the only room that we have it in. So of course, the artists. I'm like, well, we didn't realize when we were making it that to zoom in enough to see us, you were going to cut some of it off. But hopefully it's a little entertaining. Yeah. Joked. That was like old, let's just play Louis highlights or something back there while we're doing it.
You know how people make videos where they have the video and then they'll put like people playing Minecraft to keep people's attention. Just put all your old like film. Well, we could do that, but it got deleted off with my YouTube channel. Sorry. Yeah. So source, source subject for me, yes. No, there's still film of you on YouTube. You can, you could look it up. But I'm just saying my highlight tape was on my youtube channel from what, cause that was the youtube I had when I was, was years back.
Maybe I'll get it back, maybe I won't. I mean, they're still good. Yeah. You can, you can find it. I will say if someone ever tries to say I'm Illuminati controlled or whatever, You Can Trace Back to be being 15 years old on the internet with football stuff to which I was like, I am not deep state cabal or Whatever. And I know that would be like a thing if Someone said they were. But you can go back and watch videos of me when I was like 16 years old in high school with football stuff.
I don't recommend that. Jacqueline says, just finished listening to session with Sarah. Awesome. So many questions. Rancher, literally the best. Oh, thank you so much Jacquelyn. Thank you. Sarah is a wizard when it comes to peptides. And like I said, a couple of times in the podcast, there's one voice out there that I think from a peptide education standpoint that people really should know about at Sarah and hopefully as we continue to build out more guests on the podcasts and on that podcast we really just went deep on some of the more
common peptids and I think some of the things that people don't understand about some But yeah, she's a genius. We have the next one that will be coming out. Hopefully it's ready soon. Back from the editors is with Alex Kickle. That one was three hours and it was a powerhouse one. Yeah, that was that's going to be one of those buckle up your seatbelt podcast episodes in a good way, meaning that there's gonna be a lot. And that is going be that people will want to go back and take notes.
The Sarah one too. No, Sarah was too and I will also stay with Sarah. Sarah also has a peptide course. Yes. Amino Academy. And that is an amazing, amazing course. I really like her course because she does a really good job of being able to explain things that I think any level of education, depending on where you're at, it's very like attainable.
You can really process everything that she's saying. She does a really good job on breaking down and teaching it at a, just like a good way. If you're a clinician, she has things all the way down to consent forms for patients in there if you want to use peptides with your patients. And so it's worth it even just for that, which is a very effective communicator. Even myself, I can improve. I could stand to improve because I just talk and talk. And sometimes I need to condense it down into the most effective points.
She's very effective at condensing the information. Whereas I will just like to talk, get up and then I'll go down tangents of what I'm talking about. Cause I think about stuff while I am talking. What do you think about Rammelton for sleep? And do think it can be combined with the ECIP? I don't even know about Ramalteon. And so I apologize. My knowledge base does not include that. So, sorry. I'll look it up though.
Cause I'm not sure. Thank you for sharing that something for us to look into. Yeah. Do you they meant to say epitalon? Epitalin combined with DSIP is really good for sleep. Would LL37 work for those who are dealing with histamine overload? I would shy away from that. Sometimes if you look at histamines overload, a lot of times it's an autoimmune reaction.
In some autoimmune cases, LL-37 can actually backfire and cause the immune system to get kicked up even more. And so that's why I say it's really good in the case of an infection, virus, fungus, mold, things of that nature. But for the purpose of histamine overload with auto immune, you do have to be careful. I'm not saying that it doesn't help in some cases. In Some cases I've seen it go the opposite. Until I would say like, I Would not include that in autoimmune slash histamine response. I would say that more so for like some type of like fungal reaction, like any kind of, of infection is when I think about like LL 37. Yeah.
What is up wit? He says, I'm seeing some TURS and RETTA blends as well as Reta Cagri blends. I'll give you my quick rundown. We did a whole entire presentation on this inside of our group the other week about stacking GLPs together. So stacking Reta and SEMA and RETA and TURS and Cagri and whatnot. And so another benefit of being in the group is we go deep on things like that and we have slide decks and presentations for you. The shortest way to say it.
is that if you mix Reddit and Ters together, basically what you're doing is you are elevating the GLP and GIP signaling in relation to the glucagon. I think a lot of people get the heart rate increase, the nervous system increase the bad effects from RETTA in comparison to TURS from the glucagon aspect because it's so powerful at raising base metabolic rate, so power at burning liver fat. But for some people that can be overwhelming and they get very tired.
They get fatigued really bad. Their heartrate goes up. And so when you blend Turs and Reta together, basically what you're doing My best approximation is that the glucagon component is around like 20% of RETA. And don't hold me to that, that's just like a calculation I made based on the Dalton size of different things in the sequence. But in Reta, we're probably looking at like, 20-ish percent of that being glucogon agonism and about 40 to 50% being GIP, the other 20 or so being GLP. With TERS, it's about 20% GLP and then the rest is GIP.
And so basically, if we combine them together, you're still getting the glucagon, but you are minimizing that. So you basically taking down the ratio of how much glucogon agonism is going on, and elevating the GLPs and the G.I.P. component. The reason to do that would be to still get a little bit of the glutagon benefit without having it be so overwhelming as you scale the dose. So if you took down that glucagon agonism from like 20% down to now, maybe it's 5%, you're still getting the benefit of it. However, you are not getting maybe so much of those nervous system, heart rate effects that you would just from RETTA alone.
I think that's the best way to say it, obviously Rettacaggrin makes sense. You get more appetite suppression if Retta causes you to have an appetite. Obviously you going to get appetite depression if have TURZ and Rette blended together, I But for a lot of people, I get plenty of appetite suppression out of RETA. It's not an issue for me, but I know other people that don't. Can you take epitalon while on other peptides like MOTC or do you cycle in between other cycles? I think it's perfectly fine to take a epithelon with other peptides.
Maybe I wouldn't take those in the same syringe together, But yes, you could run those concurrently together and have no issues. Get bed sweats from CJC, I've been researching nootropics, wanting to increase energy, memory and focus. I'm protective against dementia type diseases. Um, a 60 year old male, I think the first line of defense for that is going to be hormone optimization. That'll be the, the line defense. And once, once that's taken care of, there's, you know, your cerebral lyosin would be gold standard for, for nooTropix, but I don't think you'd have to
go that far. Think P21 is great. Dihexa is probably great for me. It's a really good intersection of the noooTropic world. Yeah. You do get some of those Alzheimer's preventative benefits out of it through the mechanism. To me, it's way less mild than something like modafinil. Definitely. That you can use on a two to three a day a week basis. Yeah, you don't want to overuse that.
But it is stronger than CMAX and C-LINK, I think, for performance. And so the dihexa half-life is like 12 days. So you do not want use that every day. Yeah. Like I would do three times a week tops a hexa, meaning do whatever you want. I started like five to 10 milligrams, but I think it can affect your sleep. That's why, that's, why I said you don't want to use a Hexa every day. If there's a cumulative use of it every single day for several weeks, you can kind of get some people out there.
sleep-affected, but I think dihexa, nupep is a good one. Nupept is pretty good. It comes from the rastam family, much shorter half-life than di hexa. I'd say probably a similar performance benefit to it. So nopep works great, But I like di hexa. it's kind of that sweet spot. Not too, it is the Goldilocks, nootropic to me, stronger than some of the more base ones, yeah. But then also too good there. And then when you look at mechanistically, we do see animal research around the Alzheimer's component.
So I think, I, think that's a good one. P21 is such a, good peptide. Yeah. 21 would be less of a nootropic classic sense, but to the all-timer and dementia equation, probably more mechanistically directed at working down that path. And then obviously too, to beat a dead horse, but GLPs, I mean, who doesn't love a GLP? And I think when we look at that, it's one of the best things for preventing Alzheimer's and dementia in that sense.
I'm 12 weeks post-abdominal plasty. Did the BPC, TB, GHK, glutathione post surgery, not only on glutothione, HGH, BHRT, Glutathion, RETA. Still feel a lot of inflammation. Any thoughts? 12 weeks, I mean, it's still like, that's a hard surgery to recover from. I really like if you haven't used it, it doesn't sound like you have. I would like KPV. KP is one of the best anti-inflammatory peptides.
Yeah. If it feels like there's inflammation from the surgery, KP and cartilax would be really good. Would do little doses of cartillax as close as I could to that area. That's going to help with some of healing and then potentially PEG, MGF. 200-ish micrograms around there. I think those are good alternatives to get the same effects from the BPC, CETB, and GHK without using those. Very anti-inflammatory and is going to help with some of the healing and IGF-1 signaling.
Locally, that's where the PG comes in, but that is where I would go with those Recently completed a 50 milligram bottle of GHK. Prior to that, I completed 10 milligram of Melanotan 1 and a nasal spray of CMAX, all purchased from your sources. I haven't noticed any difference from any of the peptides other than mild flushing from the Melantan. Could there be a reason why I'm not seeing, feeling anything? I mean, that's one of those things that could be a whole host of reasons. And I would need to know more.
Are you using hormones or what does your lifestyle look like? How much inflammation do you have? I wouldn't say like, okay, is there a lot of inflammation going on? Do you feel like you're less inflamed? Like, were you trying to heal from anything? That would be more so covering the GHK, BPC. What was your goal with using these peptides? And then melanotin, you know, is your skin complexion? Has it deepened any? Did you notice any cognitive benefits with it?
Any cognitive benefit with the CMAX? Um, and again, then going back to hormones, cause hormones are going to play like not to beat the dead horse. I feel like we're constantly saying this, but the foundation hormones or the foundations and then your peptides can come in. Hormones are the structure, the Foundation to the house. Peptides are your decorative pieces that then. Yeah. And I mean this generally, what were you attempting to achieve?
Because you say it doesn't do anything relative, were trying to lose fat? Were you trying improve skin health? What was the goal? Cause I think if we say something doesn' work, you have to understand what it doesnt work for. Cognitive function, anxiety function probably would be my guess with the role. Given that there's melanotane and CMAX. Thank you, Portia. Glad to have you. I think I'm pretty sure if the same portion of the group. Yeah. Thank You for being in the Group.
Mike says, currently use Reda 10 milligrams a week. Something, something, BPC one, seven, low, both of them lost 20 pounds and have resolved issues with knee. That's another thing too, just to make a point. Thanks for sharing that, Mike. with, with resolved issues with knee and plantar fasciitis is how much GLPs seem to help with chronic pain, systemic inflammation relative to some of the joint issues and everything. Yeah. Well, it's interesting. Cause when was I cycle?
I don't know. I feel like, I felt like I, when I was dealing with plantarfasciatis I fell like was cycled off of. GLPs. It does seem to ebb and flow with GLP use that when you're on a GLT, there seems to be less foot problems. Yeah. Although I feel like right now it's kind of like more so than my ankle. But yeah, yeah. Plantar fasciitis is a tough one too. Doesn't just go away, go way overnight.
Can you suggest any peptide that will help dissolve scar tissue, both internal and external? I get keloid scars easily. Do you have any thoughts? I mean, that's a tough one. You could try BPC, TB 500, KPV, some of those. I don't think I would do GHK, because I can... Honestly, the first thing I'd try would probably be Carlax. Pretty cheap, and to the very least, it's just going to help improve joint mobility, helping with pain and everything.
If you With some of those areas, if you've had injuries in the past. I don't think I would do GHK though. Cause I feel like I couldn't get worse before making it better. Taylor seems to see more resurfacing of scarring on the skin with GH K. But I dunno if that would be the same for scar tissue. Yeah. Probably gonna be different for everyone too. Mike says recommendations.
I don't know if that got cut off. Mike. It was the one above the last one that we just read. Yeah. How long on HGH before I will see results two weeks? Uh, like three months. Like, yeah, I would say, see, you'll notice like a, probably the biggest is when I noticed like it was like after like nine to six, six to nine months of being on it. Yeah, I think what happens with HGH is...
Or start seeing results like in your body. Yeah. Anatomically. I notice the benefits right away for sleep. Usually you'll see benefits, right? Away with sleep, but for body composition, For me, the journey with HGH is I started it, I didn't really notice any body composition changes. And then six months, like I woke up one day, and I was like, wait a second, my body has definitely been changing. My waist is tighter, My shoulders are bigger, rounder and fuller.
And so I think anatomically for fat loss, it's a more cumulative thing. Not to say that people can't have results quicker, but I, think when you really look at the structural change of the body for the better is probably about three to six months, depending on the person. Thank you. So Fifi, we love you too. My two grandsons, 14 and 16, have celiac. I put them on IPA and sermorellin for stunted growth. Any suggestions for gut healing specifically for celia?
I would get lorazetide, which is an oral peptide that was actually developed specifically. For celiac, I will try that, but that's also in, and I'd try one of those peptides oral blends too, with razzatide but you have BPC, KPV, PEA, some of the other things in there too. My daughter is 16, has big stretch marks from both of her inner thighs without gaining weight. She's five foot, 113 pounds, been taking her skin doctor, doing microneedling, which has helped, but still there. Do you have any suggestions for that?
That's a tough one. I mean, the micreneedeling is probably going to help the most with that. Is that just from growing? Yeah, it's just growing. It's from. Growing fast. I mean, some people are just more prone, like especially like olive complexed skin tones are more. Prone to it. Vitamin E oils would be helpful, but probably doing the micro needling.
I actually started to get stretch marks on my inner thighs when I was a teenager and they've never really gone away. Now that was because I lifting weights like a maniac playing football and I got big in my teenage years. My legs, if there's one body part of me that like if I just try. or they're easy to grow. Like my legs get big. If I train legs like two or three days, my leg is starting to get huge. So genetically, that's just like where I'm bigger. But yeah, I would just keep doing that.
Your legs and your lats. I feel like my lads are lagging. Do you? I think my shoulders are better. My arms aren't as big, and my shoulder are bigger, but I have big traps. I think that was like an evolutionary adaptation to the fact that it was to protect my head from getting whacked around. Do you have the same like structure as your dad? Yeah. What's up, Sean? Got Jardience, going to add that in.
Jartience is great. Yeah, I am type one, added 10 milligrams of Jarnience. It's made a huge difference. A1C 5.0 compared to 5 point 8. Wow. Oh, that's awesome. Thank you for sharing that. I love Jardience and I would, you know, 10 milligrams is a great dose to start at because you can go up to 25 milligrams, but I've just seen so many, it's one of those things we talk about all the GLPs and stuff. Jartience, I think, some people are scared of it because they're like, oh, that's a diabetes medication, whatnot. But it seems to be so good for longevity.
And most people I hear report back on it. I take it every day. Yeah. Good morning, Xionic. It's good to see you in the house, brother. What's up, Heather? How are you doing? Good to see you. She says 52 year old female hormones tank the two-year postmenopausal mark four weeks on progesterone, estradiol, and injectable testosterone. Hopefully that is going good for you? Oh wait, she does have a question. Okay. There we go. I'll go to that and then we'll back up. What should I expect or modify when it comes to training in both strength and muscle gains?
Heather is, I've met Heather in person and she's a very fit person. So I would- Have I met her? Yeah, we've meet her before. I'm sorry, Heather. Can't see your picture. Um, okay. What to expect or modify? I'd say, you will start noticing the physique changing, like start happening after about like, six months after being on once, all your dosing is good. I would say your strength might not change that much.
I'd focus more on hypertrophy, meaning that I wouldn't focus on necessarily like trying to increase the weight of things that i'm doing. This is like if I was starting testosterone for a man or woman. i actually was stronger when i was younger with no testosterone in my body. But your testosterone was probably higher at that point. I don't think so. A lot of athletes have very low testosterone. I think a lot is just willpower, fortitude, discipline. Well, I'm not trying to talk about how much I live.
What I'm saying is that I would focus much less on the strength gains because when I started hormones, I was able to focus on doing lighter weight and more of a contraction fashion to where I really focused on contracting the muscle and your body will respond very, very well to that. Especially for a female, you're not going to get bulky or turn manly. You're going a really good response where you start to notice more like striations in the muscle, muscle will become more defined. And when the body has the gas in a tank, which is the hormones, you don't have to kill yourself from a.
weight perspective, meaning you don't have to like go super heavy. Obviously you have live somewhat heavy, I like to tell people like, usually like the 60 to 70% of your one rep max in your training is good. And I liked doing somewhere in like 12 to 20th rep range to where you're failing somewhere. It's like if you are failing at like 15 reps with that amount of weight, that's really good, Like if you're failing at eight reps, that's probably too heavy. Yeah. You're taxing the joint too much and not tax in the muscle enough. If you can do 35 reps it's, probably to light.
And you need to go back to like where you were getting really close to failure or somewhere in there, like 12 to 20 ish. Why'd you look at me side to side? There's a piece of hair. Oh, okay. When I said that you looked at, me, I was like, what did I say? Sorry. But anyway, that's what I would expect, Heather. And so I know you just keep doing what you do and just keeping doing it well, because I do know that you will start to see changes. But I'd say don't worry as much about trying to do super heavy weight or even if it was like a thing like CrossFit or something like that.
I wouldn't focus on that as that because if you really want to transform your physique. better. I like training specifically, you know, three to four days a week, doing a split, having that rep range, best way to use GHKCU for collagen building. You don't want to answer that one.
I don't like Taylor guys. Taylor's done for today. We'll see you next time. I'm going to be taking the questions from here on outs. And I would say probably micro needling, micro-needling would be good. That could be a good way to help with college and building. Obviously you can inject it subcutaneously in the belly. Yeah, that can be. Good. If you inject into an area that could help some people injecting into their face, I've tried that before. It's not very fun. For the skin, like using it topically. in a serum for the skin. I think it's more important if you...
I do not suggest taking a lyophilized bottle of THK and microneedling it yourself on your skin, I did not recommend that. It's going to end up being too strong. You can bring out old scarring and I'm getting it in serum base. What if diluted it down a lot? I feel like you still need to have it like in a hyaluronic acid for it to actually really absorb into the skin. What if you took a 50 milligram bottle, that's three mls, put three ml's in it, took it out, and put it into a sterile bottle.
That's 20 ml. Added 17 more ml of water to it. So now we're super diluted. 2.5 mg per ml, I think that would be enough. So that's pretty diluted, maybe throw in a milliliter of hyaluronic acid into it, or would that mess it up if you put that in with the backwater? I mean, no, I, you can, there is a whole different chemistry behind topical use for peptides that I probably need to study more of that.
I've talked to people that have formulated the GHKCU skincare product that I like, and there is just a whole different chemistry behind it actually being able to absorb properly into the skin. And I just don't want people to do it. It's either too strong, it's going to cause issues with scarring, or you're essentially like it is not going absorb into properly the scan and you are just wasting your Do you not like GHKCU?
I don't like injecting it, no. Is it just cause of the pain? Yeah. What about the results? Hmm. I mean, I think the result's topically and the like orally buckle delivery have been great, but I also think that like, Healing wise, like when we're talking about healing, I think that you get better results healing with TB 500, Cardilax and BPC.
Yeah. I mean, the GHK doesn't hurt. Cardillax would be far superior for healing an injury than GH K would, in my opinion. You know what I, think GHk makes my back hair grow like crazy. And take one shot at GH and a week later, my bag looks like a werewolf. But I don't think it works like that on some people's head, unfortunately. No. I always feel bad to talk about hair loss peptides. One, because I really don' know personally what it feels like to deal with hair-loss.
And so I didn't want to tell people, hey, use this peptide, but I've never really dealt with it. Although I could categorize and put together information on it, there's a lot of newer stuff coming out. There's AHK, CU, I think you could microneedle that and probably have good results. There's another one that's called KY 17 332 or something. I'm probably missing the numbers. There was another, I think it's PP 405 that you can get at some research places now. It's like a topical solution.
So there's stuff out there. Yeah. I'm currently using 1.5 I use of HGH pre-bed, planning an experiment with adding Tessa. Do you recommend moving the HCH just in the morning and using Tess at night? Personally, that's what I would do. Other people might tell you different, but I like the TESS at nighttime because it pulses the pituitary, which is much more in line with our circadian rhythm to do that at a night than it would be in a morning. Doesn't mean it's bad in morning, But I will do it that and then take HGH in in mornings. Would be my recommendation. That's would I do and have done.
How long did you take Jordians for? Are you staying consistently Jordian or cycling? I take it every day. Yeah. And as it stands right now, I don't plan to cycle. It might not be a bad thing to psycho, but for me, just for pregnant. But for, me I plan on staying on it. Are there any peptides to treat UTI? I think, do you think that, I feel like Jardians would be beneficial to take if somebody is getting Cronk UTIs.
Well, it actually can induce UTIs in people. That's one of the side effects. Yeah. Oh, okay. Nevermind. I should not have said that. It's probably a certain subset. Maybe have like kidney stone issues. My guess is that it is inducing it and people that have high uric acid. Why that is, I don't know. I would need to read more about it, but it is a rare event that people get increased UTIs from guardians. And I think it's just because they're obviously urinating much more frequently.
Do you think SS31 could be beneficial for UTAs? I guess SS 31 would be a beneficial thing. Yeah. LL 37 would probably be like, if it's an infection is at least going to help support the immune system. Yeah. 5-Mesophil-1 would be helpful, but specifically for a UTI, that might just be a pharmaceutical prescription thing too. That needs to be dealt with.
How many have you had before? I've only had like two. And it was like when I was younger. Just been diagnosed with lupus. My main problem for now is inflammation on the scalp and tinnitus. Any peptides to help? I mean, starting out to just be very basic, I would get started with BPC TB 500 KPV, see how that does. And then you could kind of go from there to say, okay, maybe I want to bring in some thymus and alpha one.
Maybe you want bring it in something too that could help with the brain inflammation is going to be cerebral liason. So you can potentially add that into. That would be my just, just getting started advice for lupus. Obviously those are very, they get very complex. The reason I don't talk about them as much as I get, very good complex, you know, lupa's is not like saying, Hey, I have a torn shoulder. It can be very dynamic of what's going on. Its auto immune, neurological, and there's a lot of stuff going there, but I think at the very least those, are going to be helpful.
Good morning, Katie. She says she has a question about glutathione. Is this something that can be, would be supportive to use you around currently taking 150, I think she meant milligrams, two times a week for baseline health support since I'm using range of peptides. Yes, you can. And that's what I do. I take it twice a. Usually 100 or 200 milligrams twice week. It'd be using it anyway right now for fertility, but I, take. All the time. Two times. For life. Don't think you need to necessarily cycle that. Yeah. I think the only time you'd want to add more in is if you're dealing with some type of like, like mold.
Yeah, there's like a chronic immune load, immune issues going on, but if your healthy, just for maintenance dose, I that's good. Stacy says, my HRV dropped when I tried several different injections. It's tested if an HGH. Have you seen experience this? Does your body eventually get used to it? Yes, that's very common. Yes. Your body will get use to. And really what's happening, I mean, obviously everyone's case is going to be a little bit different. What's. Happening is that your metabolism is. Going up because you're burning more fat.
You're the, all of those things that you were talking about, they're going. To increase your. Metabolism, increase. Her metabolic rate, increased output, everything. And when you do that, the body's going to go through a transient fluctuation to like more of like a stress adaptation. Now the metabolism higher and eventually it'll normal out. And ultimately those should actually help improve HRV because they're going help, improve sleep and everything. But yes, that would be very common when someone is starting out to see that.
I'm having trouble raising my free testosterone even though my total testosterone is over 1200. I heard someplace that taking proviron will reduce SAPG, which in turn would help raise the free. Yes, that is absolutely correct. I mean, if you want to even be as simple as taking boron and zinc to start out, I think to the SHBG, a lot of people don't realize, like a lotta guys don' realize that if your SHPG is higher than normal and it's preventing your free testosterone from coming up, A lot a times there could be something in the body, Like a toxin or toxic load or like inflammation that's causing that.
And I would look at that first like, okay, they're like endocrine disrupting chemicals or things of that nature that potentially could be doing that. What is my body fat like? And so if my bottom fat is really, really high, that's going to raise SHPG, which would then keep your, prevent you from having higher free testosterone. You could take zinc, you can take Boron. And then obviously, yes, the hammer to the, to answer the question, Proviron would be the Hammer. Okay, boom. That will go in, manually drop SHBG raise free Testosterone.
So yes. you could definitely do that 25 milligrams a day. No problem. But yeah, it's more complex than just saying, hey, you know, no one has a proviron deficiency. Usually there's some upstream things that could be worked out to then, but again, provirons will solve the issue if you want to. Kelly says, okay, to add a little sodium bicarbonate to a cloudy pep for pH balance so it becomes clear. I don't know about that one, Kelly, I would say try it and see what happens if you don' mind wasting it, and making it worse.
But I dunno, if the sodium by carbonate would clear it up if it's cloudy. A lot of times if its cloudy to me that indicates that it could be basically inert or its basically denatured. So it is not useful anymore. But I've never tried that. So testosterone, it will take a while for it to be delivered. Well, let's see, HCG help with that? Yeah. It will raise your total testosterone for sure. Yeah, you could raise it with HCGs.
You're just not going to get therapeutic effects of testosterone. But if, if I didn't, for any reason you banned me from having testosterone HCGS would probably be the next best thing. Sean, the podcast with Sarah is on Spotify. And if you go on YouTube, I made a new YouTube channel called Hunter Williams podcast and it's on there as well. Spotify, and then you could search on youtube. Yeah.
I guess that rent remelt or metal one. Not sure I've never, yeah, never read about that one Would it be overkill to do sermoralin and DSIP on the same night? No, I don't think so at all. It would be no different than doing epimerelin or testimeralin. I guess it's a melatonin receptor agonist. Yeah. The same as like kind of like set melanotide or still different.
No. Set melantide is. Oh, nevermind Ed. Um, so Melanotide is, comes from the Melantan family, but it's just the appetite suppression. So if you really want to get appetite suppressant to where you feel sick, you can take, I don't know. Yeah. Like it says, Decept plus Epitalin is much better. That's what I, decept and epitaline work really well together for sleep architecture. 33 year old female has thyroid issues and Hashimoto's, what would be your protocol to help with that extremely tired medication the doctor prescribes makes
me feel terrible? What I would do is desiccated thyroid, testosterone, progesterone, thymus and alpha one, possibly all 37. Actually, no, I'm taking LL37 out and low dose nitrexone. Yeah. I think first of all, get your testosterone check because that could be part of the issue as well.
A lot of 33 year olds have fatally low testosterone. They don't realize it and their testosterone comes back at 13 or 14 total. on the blood work and the doctor's like, oh, your testosterone is normal. To which I would say that would be like a death sentence for a woman to have that low of testosterone. And so I'd get that checked first. Then from there, I will say, okay, now the thyroid, desiccated thyroid where I start, would also get thiamin-sulfo-1. I also would get low-dose naltrexone.
Typically those right there are going to be a good, pretty good chemical signal to start getting things going in the right direction and get you on track. So that's what I do. I'd say with just those things right there that we mentioned, you'd probably be well on the way. What's good to take to get rid of lactic acid after weight training, recover from being sore immediately? I would really like, I mean, you could take it before weight-training. What really helps with the buildup of Lactic Acid is DADA, Dioisopropamine Dichloroacetate.
Say that 10 times fast. Just call it Dada, d-a-d-A. And you can get that, as an oral, get as injectable, but that actually like it will increase the threshold to which your body will start to build up lactic acid, which makes it good for endurance, makes a good weightlifting, and you definitely don't get as sore. I've actually been using a transdermal one lately and that's worked to me just as well, I think is the injectable milligram for milligram. Yeah. There's also an oral dropper. Yep. You can get an aural droppers or oral capsules.
And obviously there's the injections too. But yes, that would be my go-to for that. Live edge table looking good. We had to paint it, get it right. I know, I didn't check the, see the spot that I had a paint with it. It dried fine. Yeah, so it's not on there anymore. Oh yeah, you can't even tell I painted it There was a little spray paint stain from where we got it from the reclaimed wood place here in our town. But Taylor painted over it and it was good to go.
Walnut reclamed wood. If anybody has done epoxy on anything, please email me. We can also probably look it up, but not be lazy because I'm lazy when it comes to that stuff. I feel like I'd be the one doing it. You wouldn't. Yeah. How would you recommend for my daughter to take the KPV capsules right before her period starts or daily for eight weeks on, then eight week's off?
So if you could play with it and see, like, I don't think it would hurt to use them, but I would say maybe have it start on day like 14 of her menstrual cycle. So that's kind of like when she's going to hit her literal phase and have that be starting at day 14 in her cycle and then having that maybe be like the, the eight weeks that she starts it. I mean, how long can you stay on the Orals before building up a receptor? Is there, I think- I'd think you'd probably stay- Stay on it for- A long time.
A Long time, that's kind of a thing too. But maybe I would have her try it on day 14 through 28. I'll see if that helps. Yeah. There's probably a different attenuation response to the orals than there is injectables because they're less bioavailable. So you're not getting the tolerance built up of the oral. Podcasts with Sarah, just look it up on Spotify, iTunes and YouTube, Hunter Williams podcast. It should come up right away.
I have an ocula aura that reoccurs that it caused me to head to a dark room for 20 minutes. I had researched SS-31. It seemed to be research to try out for ocular problems. What do your y'alls take? I think that is excellent. You could do injectable SS31, I would also try to do SS 31 eye drops as well, you could that. And SS 30 one eye drop worked pretty well. How would you make SS30 one eyedrops? You're the eye-drop queen. I mean, I would just do it.
I was, either saline or contact solution to reconstitute it, don't use backwater because it's going to burn really bad. And it still, like, it kind of burns even with the salines and the contact solutions. So yeah, all you have to do is reconstitute saline solution or, um, contact solution, pull it out of that, put it into a dropper and then add some more contact solutions. Probably. I like like a 10 ML bottle and fill up the rest with contact.
And so when I made it, I've only used, no, but it's an eye drop. So you don't want to ask, cause if you think about it usually you're doing like two or three drops. You don' want just like one, like I would much have a less concentrated I mean, at the end of the day, you can take very high doses of SS-31. It's not a deal breaker. Is there a peptide that helps metabolism headed into menopause?
Hormone replacement therapy is what you want. testosterone, that is going to be desiccated thyroid. That's going be more beneficial than any peptide. And then a GLP would help as well. I think Taylor and I were talking about this this morning before we move to the next one, just as a topic of conversation. Peptides will be the gateway drug to hormone replacement therapy in the coming years.
Yeah. I agree. Yeah. Many people come to peptides and then they realize that the hormones peptide's are the nice to haves and the hormone's or the need to have. Yes. Just started with Tessa, just started Tess with red about two weeks ago. Once I started seeing weight loss, I've seen a little bit, but thought it might be more with my training. I don't know, man. I mean, that's, it kind of is, It's hard to say.
How many calories you're eating? I dunno how often you train. It does not like your training, which is good, but it just kind depends. The dose that you are taking. So it really is. it is so highly individualized that. You can't say that, Oh, in two weeks. But I will also, if you a leaner person too, If you already are lean or like, I always say give something at least eight weeks, Yeah. Also too, there's this whole thing. People want to take a GLP and just have the fat melt off.
Unpopular opinion, but I think if you're losing more than two, no matter how much weight you have to lose, if your losing, more then two pounds a week, I'm not saying you can't do that. Cause you obviously can if take the high dose. There will be a consequence at some point. If you are losing the weight too fast, you losing muscle. Yes. Well, it becomes a lot harder to have muscle too. Yeah. Because you're not gonna have the calories that you need. Whereas like if you are losing weight, one to two pounds per week is actually really good.
Think about that. If you doing two-pounds a week, that's eight pounds a month. And then over a course of a year, That's 96 pounds. That is just two pound a weeks. So I just want people to remember that if your losing way too fast, There's, I'm not saying you can't do it, but there's going to be a consequence, a neuroendocrine consequence of thyroid consequence to which you're going, to push the body into starvation mode. And then there was going be blowback from that at some point. But that being said, it's just one of those things you don't have enough information to really say one way or the other.
Would you treat valley fever with your autoimmune protocol and maybe add in a lung bioregulator? Any other suggestions? Yeah, I think that would be the best start. And then you could throw in brocogen. What about VIP? VIP could help. Yeah. I would put that in the autoimmune protocol. So VIP it could be good. Get some red light therapy. Amen, Shannon. Yep. That's exactly right, Heather.
Focus on hypertrophy, splits, and aesthetics. Yeah, it's okay. Yeah. It's not great. The injectable to me is far superior. I kind of written five amino off before the injectible became available, but yeah, It is not bad. No. Jardience and kidney stones. Any info on that? Not off the top of my head. After I'd have to read more data on Sean.
And I'm sure it can probably be a side effect for some people. Why, okay, so let's have a little teaching moment. Why would that be a side effect of Jordians if it's removing the insulin from the kidneys? Wouldn't that help the kidney function better and cause less kidney stones? Or is a kidney stone gonna be more triggered because of diet and uric acid?
I don't know. Jordians is blocking the reabsorption of glucose by the kidneys. And so rather than glucose being re-absorb into the kidney to make it process again, it just gets peed out. But in some cases, depending on the health of the end user, at the start of that, the extra urine that is coming from that potentially could have, I dunno if it has like a buildup or something. That would be my best guess. To be honest, I haven't read that much about the side effects of Jardians in that sense.
It seems to be in a very small subset of people. I really started exploring spiritual wellness and love it, but really moving away from organized religion. Have you heard of that before? I think I have Jim. Yes. Love the spiritual idea about the church. I. Yeah. It's one of those things. Do you don't need an intermediary to dictate what your life looks like and what you're spiritual connection looks. So I, I mean, a lot of people feel that way. And I would say that's how we feel.
That's a very, very important piece of my life, I don't necessarily need a church to access that if that makes sense. I agree. But at the risk of just making people mad, I will stay away from talking about that. Maybe that'll be like a podcast day or something. Maybe that just needs to be a private conversation. I don't know. If people would hear it, there's a lot of stuff I would like to talk about that I won't talk like that.
When it comes to religions, stuff like people can get so... You just invite people to teach you. Yeah. in the bedroom. I had some candles lit and my sound bowl in there and me doing yoga in my bedroom and somebody wrote me a very nasty message about not understanding that they thought I was a Christian. But I just didn't realize that. Would that be the Christian thing to do though? No, it wouldn't be.
But do you like, do some Christians think that yoga is like witchcraft? Like I didn't know that. I think people think weird things. Okay. That was so odd. Yeah. Cause I don't think of like yoga as a religion. Saying you're a Christian is kind of saying you are American. What does that mean? There's so much that that could mean, you know, I dunno. I would want to, if I do a show like that, I want come in with my thoughts organized around that topic.
I mean, you're going to get haters. Anything I can do for my finger that's inflamed and painful from arthritis. I get steroid shots, but they're not working. BPC, TP 500, do anything. Yeah, they definitely would. My fingers were really sore a couple of weeks ago because Taylor got me a guitar for Christmas and I was playing more guitar recently. And my wrist and my fingers on my left hand where I playing got really soar.
I realized like, Oh man, I've been playing guitar more and my finger's not used to that pattern of like moving them out like that and move them around in that manner. I injected some cartilax into that hand, you know, just pinch the skin, pinch, the scan, slide it in. Yeah. Not like directly into the hand. Just pinched the skincare and then slide into a pinch skin man. Like in two days. You can even do like into their wrists. Do it on a wrist. That's I didn't like closer into my wrist and that helped my whole hand but yeah.
Seems to work great for that. Yup, I feel like hydroxychloroquine, hopefully I don't get banned for saying that, has helped with lupus plus TB500, TA1, BPC and KPV. Very good. My thymus and alpha 1 reconstitutes cloudy with suspended particles. I tried adding acetic acid, water the backwater, but it's still cloudy. And I asked the manufacturer to do a test in their factory. Yeah. Typically that's not, thimus alpha one is actually one of the most easily mixed peptides. Like typically you'll mix right away.
Usually you never have issues with reconstitution with that. Yeah. And they just like there, it could just be a bad batch and it's nothing against that comp, like the peptide company. Like sometimes there is just sometimes a vial, whether it is coming from a compounding pharmacy or a research company, basically same things, but in my opinion, I think you just, sometimes you get a bat batch. Just like sometimes. You get. A bad strawberry in a container of strawberries.
Yeah, Sometimes you. Get a green potato chip. Yep, Shannon, a prolonged calorie deficit can lower SHBG, turn to maintenance calories for eight weeks and lower mind. Tried switching from estradiol 0.075 patch to injection, but getting a huge swing of high estrogen effects. Week one did 0,06 milligrams and then week two did, two and three split dose of 0.,03 and 0,.03 suggestions.
Well, 0.06 milligram for an injection sounds very, very low to the point. I don't know if that's 06 mls. And I know the concentration, but actually the reason I say that is because I dunno how you would actually get 0 6 milligrams. If even if the estrogen was made at 10 milligrams per milliliter, that would be very hard to get on a syringe if you're injecting. So my first guess is that like, If it's estrogen at 200 milligrams per milliliter injectable and you're doing six units,
that's actually a lot of estrogen because what would that be? It would basically be like 12 milligrams, which is a lie. So the patch still be in, it could have some of the patches too is like lingering in the system. You're adding an inject on top of that to which it was going to cause the swing. So I don't know. I mean, I would ask Lauren, if you could tell me the concentration of the estrogen or estradiol that you're injecting, like is it estrodiolcipinate and
what it's compounded at? That can help me answer better because for my understanding, it would be almost impossible to inject that much estrogen unless it made it like one milligram per milliliter, which I've never seen before from a compounding pharmacy. Yeah. So. Suzanne says, back to the question about allergy. I've used VIP for a while and I think it has helped a lot.
I didn't even think about this, but the, for the viewer that was asking about the PMS symptoms with their 19 year old oxytocin would also be a great peptide to try. Um, especially like the even like, the nasal one would be good one. I don't think even about, I always forget about oxy, although I love it and I use it. Does TB4 FRAG work orally as well as KPV orly? I would say KPB probably is better oraly, but there, I have seen that TB 4 Frag, which would be TB 500. TB500 would 17 through 23. But I'd say yes.
Is it a good injection? No. but I'll say, yes, Taylor, what is a pre-workout injection. I like injectable choline and injectible L-carnitine. Yeah, those have been my favorites lately that I've been using. Yeah. My go-to right now is L-carnitine, Dada, and some choline and then some aminos too, some glycine taurine arginine glutamine.
And you can get those obviously from, I'm not talking about where the sources are, so be on the email list for that. I just sent an email out earlier this week with the sourcing. iDoc recently shared concerns about possible macular degeneration, eye disease in my left eye, any perhaps help might slow down the disease or stop it. Any perhaps worth trying. Actually, I would say the first thing is typically when you see macula degeneration, it's a vascular issue to which a microdose of a GLP will help. From there, SS31 has the most data around maculadegeneration to help with that.
I think P21 does as well. And so P21 could be good as well. BPC-TB500 I'm sure would not be harmful, but those would be my go-to first. You could inject those and do eye drops, the ones we mentioned. How often can I take Cagri along with my regular 2mg weekly dose of Reda for appetite suppression? I would do it just at the same time that you do the red. And so I like starting with 250 micrograms of Cagri, and then you can kind of up from there.
But some people have like this weird dopamine response where it makes them really sad or hollow feeling. Yeah. From there, you will see like, okay, this is like good for me, or this not something to do. Kelly says, is Jardians at AgelessRx? They don't have Jartians, but they do have a couple other ones. I think it's Invokana and Branzabi, which are the same class of SGLT2. And I one's like a hundred bucks a month and the other one is like 400 bucks per month.
So yes, it is there. Then TellyRX.com is another pharmacy, legitimate pharmacy that you can get it from. T-E-L-Y-R-X dot com. No affiliate code. Probably should. Don't care though. So sorry, I know you've answered this question previously for the life of me. I can find it by combing through everything. Oh, scroll down a little bit. Is it down? Yeah. Sorry. Well, maybe not.
Look real quick. Sometimes I come through and then other people put it. So I don't want to lose my place. Yeah, it will see a bit pretty. Guys with sourcing. Can't really talk about that here. It's hard enough out there. Sorry. Jordans versus Nesformin. I must be sensitive to metformins because it really affects my workouts and strength. Yeah, I would say if I could only have one, i would take Jordians. yeah. i still think met formin has a place, but if you don't like it, Jordian's and GLP will get you all you need.
So i like met forming because i feel like he keeps my gut bulletproof from like any sort of issues, more so than guardians would be. Yes, the HRT provider quiz. We're doing our best to get back to people. I apologize for that. If you just send an email to me, I'll make sure it gets handled for. That Katie said spiritually spirituality conversation. Yeah.
All my hormones are low, almost none existent. So doctor prescribed estradiol and progesterone. Go figure. But we'll not do anything for my testosterone. Total test for free test is less than 0.2. I would find a new doctor and I will not take estridiol. Yeah. Without testosterone, send me an email. Can help with that. Just so many help you find some, but we will have bigger solutions. We do have more resources for doctors now.
Let's see. I do feel like the... Yeah, I see that. Yeah. Do you feel... I'm sorry, guys. The chats are coming in. There's a lot of repeats too. It's like duplicating them for some reason. which I don't know why, but that's okay. I'd rather have duplicates than not see that. Can I use sycamore instead of cartilax? If I didn't want to use an injectable, what's the difference between those two? You definitely can. It's just not going to work as well.
And if you think about it, obviously the oral one has to be digested by the stomach and then get to where it's going. Then the injectables is going go right where needs to at a hundred percent bioavailability. So I've seen people have good results with sygamere, I'd say it's going to be like probably more systemic and less effective, whereas cartilagin can be more site specific and be much more effective. So if you really want to avoid injections, sure, you could do that. But I just don't want tell people like, oh, just take some sycamore and that's gonna solve all the problems because it probably won't.
Here's Brittany's question. She says, what is your recommended average levels for women's HRT results and also for testosterone for men, please. So for woman, I would say free testosterone anywhere between like closer to like five to 10 total, anywhere from like two to four hundredths. And then for man, As high as you possibly can take it. No. Um, I feel most men feel best between 1000 to 1500 with their free being like 30 to 50. I think there's like a threshold point where your free goes over 30
that you really start to feel a lot better. And then I, think probably like I usually sit in the forties and I felt really good there. But yeah, those are the levels. Obviously there is a whole lot more to that than just the level. I would say have symptom resolution once they get over 200 total in their freak. It's like over three to four. Yeah. Would you agree? Yep. Here's Jen coming in with a more clinical answer that my brain or Taylor's brain does not have the capacity to understand,
which I say that because Jen's a genius. And she says, Jardine is helping us extract glucose. If that glucose is delayed in our renal tubes, glucose can harbor bacteria, hence risk of ETS. That would be, it sounds a lot better than what I said. I would say probably yes. And I'll actually, now that we're talking about this. That's why Jen's our medical team in our group. Yeah, that's right. Jen, we have her in her group and she coaches people. Okay.
So Kelly says that the sodium bicarbonate and it did turn clear. It may still be good. Ben, so I have a podcast channel, a new podcast on YouTube. It's just called the Hunter Williams podcast and the profile photo is just like a little vial. Hopefully that's not too risky to have, but so, I had that that we'll be publishing our podcast to. And right now I'm having a lawyer that is interfacing with Google.
to hopefully get my old YouTube channel back. I don't know if it's going to come back though, but the reason I haven't made a new one that I just am publishing to is for two reasons. One, if I do get old one back, I didn't want to have a one, that then I'm just like double posting stuff on. Two, YouTube will recognize from my IP address if its me. And so I can go make a New YouTube Channel, From what I understand now is that they would immediately recognize it and might not happen overnight, but it would just get shut down again.
I would much rather go through the due process, which has taken this long to attempt to get it back through like above channel means, buy someone underground. Meaning there's people in the black market that will pay people to take YouTube channels down. And I'm pretty sure that's what happened to me. You have this whole world of people paying people, crypto, which is really sad that you have people. These companies that we'll take bribes from people who shut down people's channels. But I think about how much like, think of how disgusting that person's soul is to want to be that evil.
I can't speak to that. So like I mean, that, I don't know. That's on them. It is crazy what is allowed. I would say it's crazy. What's allowed to be on YouTube versus what we've gotten kicked off for. But, um, and so that's why I haven't made like a new one that I post to is because even if I make a New one, they'll know my IP address. And so the podcast one actually had set up through a different IP Address. So like that one will be there, but I don't have to like go through our VPN every time I like going to YouTube. and So I'm attempting to get it back through normal means.
If I do, And if I don't, it'll just be one of those things like I have, but at least I'll have the podcast where we publish the guest interviews through that podcast one. And we'll see how that goes. We're going to be diligent with it. Company I'm using in China has a D rating on Fenrick for not leaving the files when submitted. Plus purity was 98 and they downrated to 1.9 out of four stars important.
I don't think anything on Finroc is that important to me. the most people when it comes to the peptides supply chain. And that's why I just laugh. I'm not saying Finrik is like bad in principle, but I laugh because I know that there are companies on Finri. that the peptides come from the exact same factory and one company will be rated an F and when a company would be rating A. I know for a fact that multiple companies that are on there are getting their peptide from exact the same place in China.
And I now that they are rated differently. So what does that tell me? Like we were talking about earlier, there's a variation in batches. Also too with Fenrick, people are user submitting files. there. So if I wanted to, maybe I could buy a vial from a peptide company that I didn't want to have a good rating, take the label off and put another label on and send it in, say it's somebody else. Yeah. Why are people so hateful? Like, why? I'm not saying people are doing that. I am saying the potential for that exists because you can mail in a sample to Fenrick and say, Hey, this is such and such company,
how to test it. And then they'll test and hate people. But people like, I know, but it's not, what are we going to do? All we can do is to what we do. Point being is like, I'm not saying this specific company George is good or bad. Cause I don't know. What I do know is that this whole idea of like peptides testing at like 60% purity. I just haven't seen that in practice. But what I'll say, 98% purity. You can have a peptide vial that's like 99.3% percent purity when it goes off of the line at the factory, and then it gets shaken around in manufacturing.
That doesn't change the sterility of it, but it might lose potency to which now it's going to test at like 98.7% because it has been moved around so much. And so when we say that- It's not really necessarily like a cleanliness thing, it just Yes, exactly. Like it doesn't mean there's like endotoxins in it. It doesn' mean that, you know, there is that in the other. And it just means that like the degradation once it came off of the line, and there was also a time component of that too, where it's now like maybe three months old, doesn''t mean ther's anything wrong with it, it''s just not going to test as high from. purity because it's lost a little bit of potency over time.
And so a point being is like, I don't trust any of that stuff for me. I know where to get peptides from where I knew they're good. To me, that's what matters. If I were to talk about which companies are good and which are bad, i'm just going to be targeted that much more. So I'm not going do that. But this whole idea of like testing, people don't realize that a lot of this COA stuff is kind of a marketing gimmick. And I'm not saying that the COAs are wrong. I mean, I've not said like the companies are testing or doing a bad thing.
But if you have a batch of 1000 vials and you test one vial, how do I know that that one Vial is indicative of everything in the batch? It's like if pull a bag of potato chips off the line, And you said one in a thousand bag, you tested it. I was like, Oh, these are good potato chips. How do I know there's not a green potato chip in the other one? You can't like you can possibly do that. And so that's why the whole COA thing, it makes us feel all warm and fuzzy inside. If we see the number come back at like 99% or whatever, but I'm saying it's like. But that not what's in your vial.
You know, so like I really do have to trust where it coming from to know with a reasonable degree of certainty that there was. intention and everything put into that vial to be done properly and just have the faith that like, okay, this one is going to because it, you literally cannot test a peptide vile. You'd be like you can't test every single vials. Yes, because then you would waste, like can test the viles and then actually. Then you cant resell it either. Well, yeah. Yeah. So like, if you're a company, you can't like send one off and then have it sent back and sell that.
That's what I'm saying. And so it's like the whole COA thing is really a way to have like a marketing differential. It didn't start off like that, but that's, what it has become because again, these research companies are buying vials in the thousands of quantities at one time and having one or two viles tested. I'm not saying that those are bad, obviously, but what I am saying is that one vial doesn't indicate to me what the other ones are saying, because if you tested five vials from the same batch of it being made to the manufacturer, you're gonna get five different purities and everything on it.
But what you need to be sure of is who you are buying from has a reasonable degree of certainty that it exists within this and that I trust that source for where it's coming from. So that's all I know that led to a massive rant, but this whole idea of like Finrec and these companies and doing this, it is hard to pin that down. Do you think with that, do you some peptide companies are also paying to get better rankings?
On Finric? Yeah. I don't know. I mean, possibly anything is possible. How else? I dunno how they make money. So, and maybe they don' money, you know, but, um, I think the point being is that like, if you want to look at that as a guideline, that's totally fine. But, I just know so much about like the supply chain and stuff with peptides. Yeah. Of course there's places with better quality than others, but I think this we've, we probably swung the pendulum of like getting so into it.
They're like people, they can't see the force for the trees. And like that's what, if people understood that concept right there, that one vial is not indicative of the batch that it was made in. you have to go beyond just testing that bio and understand like you to trust the place where it's coming from to know that that's of good quality and that the everything is made properly there. And so ultimately you can, you could go buy from a Chinese vendor. You can go by from whoever you get it tested yourself and hopefully it comes back good. And then you like, for me, I'm not like okay, like I can be reasonably certain now, but like everything is me.
But here's the problem too. If you have a supplement company, look in the supplement world, there are supplement companies that if you go to have supplement made from the manufacturer, say, Hey, want to make a vitamin D supplement. They'll make it for you. Comes back, gets tested. Boom. It's 99% pure. Okay. This is a good manufacturer. Well, who's to say they don't start cutting it in future batches? Yeah. So unless you're getting every batch tested, which then is like, okay, you need every. Yeah, now that's going to cost thousands and thousands of dollars. One test on most peptides, one vial is usually like two to 300 bucks to get it tested.
And so you just run into this issue of like. It really comes down to trust. Yeah. And that's what we have to go off of. I'm all for testing. Don't want people to think that I not in support of testing, but what I also saying is that like you have implicit trust in the people that you're dealing with or whatever. and I am not saying that to like come to me for trust, I saying like, you got to have that in your own life with whoever you are dealing Thank you,
DD, Nudipeptides, love the show, so informative and genuine. That's what we attempt to be, hopefully comes across. Does injectable all carnitine and choline hurt? I don't think it hurts except that. Injectable glutathione hurts way, way worse. What would you say the scale of one to 10 is? I mean, sometimes it's like a one, and then sometimes, it can be a three, but never really higher than a 3. And I think it just also depends on the company. Because there's some companies that are smoother than others.
You have to make sure you're rotating injection sites, because if you go back over the same spot, that's going to be more tender. But for me, It's no higher I think the post-injection pain is worse than the injection pain. Yeah. Like with the, the carnitine and choline, it'll hurt more probably eight to 12 hours after. Then the actual injection will hurt. It might sting a little bit, but typically it's depending on where you injected, how you inject it.
I would say like stinging level glutathione is like an eight for me. And I'd say ingestible L-Carnitin and Choline is never really higher than I Yeah. It's just that sometimes you might get the bruise after the pain after. What is the correct dose of testosterone for women suffering from libido issues? We saw five milligrams everywhere, but Dr. Lyons says 10 milligrams. Well, I think every, there's no right answer.
He actually finished, he said, we tried that and he got facial hair. So there's no right answer. Like one dose is a great dose for all women. Every woman is going to be different. So like 10 milligrams might work great for one person. Five milligrams. Might work better. You know, eight milligrams might be your sweet spot where you get the increase in libido, but none of the masculine side effects. Yeah. So I think it's like, it so important that the first year of, you know.
Using therapeutic testosterone the year is really testing and figuring out where your suite spot is to help with. all the, to help with the negative side effects and then also make it to where you don't get the masculine side-effects. You know, the hair thing is, you know sometimes you might feel better at a higher dose where the native side of facts are being treated, but you may notice a couple more darker hairs coming in. So you kind of have to figure out like where.
The trade off Also is to you know, if it's getting to the point where it like massive amounts of hair if its like three to five hairs like okay, where is the trade-off here like is it worth feeling cognitively better and Living a healthier lifestyle and it is like yes annoying. I have like five Hairs that I had to deal with like which is more important Yeah.
Well, I would say this too, this is, we would need more information. I think the frequency of the dose could also affect that too. So if you're doing 10 milligrams once per week, that's going to cause a huge spike for a woman versus if. Took that and broke it down into three milligrams, three times a week. Or maybe you were even doing sub cue injections every day. Yeah, so what if he did one and a half milligrams every. Day of a subcue injection. that is going to smooth out the peaks in the trough to which you won't have as high of a spike that could then lead to those effects.
I would also say specifically around libido, there could probably be, like maybe if a woman gets to her threshold dose to what she begins to virilize, assuming that we did that with the injection frequency, we smoothed it out. From there, depending on where her estrogen is at, she could potentially introduce a microdose of estrogen on top of that to help with libidos. because she might just not be aromatizing enough estrogen out of the testosterone. She might be good on the Testosterone. There's still not enough libido.
You could potentially not have your estrogen levels high enough, especially if the testosterones doesn't go too high. Say she gets to like 180 total testosterone, she feels good, but the libidos not there. If she goes up more, maybe she starts to masculinize where some women, they can go to 600, and they don't masculinate. And so maybe, she's like good at 180, but like after that, you start to masculineize. But the estrogen is maybe coming in around like 60 or 70, which is still kind of low for a woman. Then maybe you add in like half a milligram, one milligram of injectable estradiol per week, to which then you would bump the estrogens up. Until then, that would probably help with libido too.
Because testosterone is very important for libido for women, but also estradiol will affect vaginal lubrication, sex drive, mood, everything too. And a lot of women aromatize enough of their testosterone to where they don't need that. But some don' fit from it. Good question though. Very good topic of conversation. You mentioned the pre-workouts that you're liking right now. Can you talk about how to reconstitute and dose for them? You actually, the good thing about those is you don't have to re-constitute them. They come pre mixed because most of those compounds are stable at room temperature in the solution.
And so you can actually just use them right away. Typically it's anywhere from like 0.5 mLs to 1 ml of each of them, just play with it. Maybe I should make a injectable pre-workout cheat sheet with all those on it. And then like people have asked for that for a long time now. Yeah. Or injectible by regulators, more effective than capsules, 1,000%. They're more affective than capitals. I said, the caps are good to run in the background just for like health and longevity purposes, but for the actual effect,
a thousand percent the injectables are way better. You inject cartilax at the specific site. Yes. If you have an injury, yes, I would do it at this site if it's just systemic arthritis or like, you know, your whole body hurts you creaky and everything. But for injuries, Yes, that would be right. As close to the site as possible. Jardins is expensive. That it is. They know it the good stuff and that's what they charge so much for.
Unfortunately, even with the insurance is still pretty expensive What if a test of peptide purity comes back at 88.7? It's still going to take it. I would, uh, at that point it becomes like an endotoxin thing. So probably no, because at point like you do have room for impurities to be like, okay, like there's probably some impureties. And so, but obviously too, does that mean that whole batch was that bad? If it was, then yeah, I wouldn't, would stay away from it, so.
Yeah, probably say no to that. I don't know why other people's YouTube gets to stand up, whether that goes for like whoever, I cannot answer that question other than my guess would be that I'm responsible. And I won't say this, please take this like I mean this in the most like non-arrogant way possible. I am probably more responsible for people directly using peptides on themselves than a lot of other Meaning that the information I put out,
my goal with my information is to where you don't have to pay me for anything to be able to use peptides. And in the process of doing that, I'm probably more responsible, therefore I probably have more of a threat. Whereas a lot of people just get on and will like rant and rave about stuff. Mm-hmm. It might be entertaining to listen to, but how practical that is, that I don' know. You can leave watching your video knowing exactly how to us the product. I feel confident knowing that most of the content I put forth, someone can watch that.
And that's more of a threat. You act on it than probably other people who just make content that is more passive entertainment around it. I'm not even saying that, I think that that a bad thing. No. There's a room, there's like a market for passive entertainments around peptide stuff. Yeah. It's cool to like just listen to it, it's kind of like if you listen like the mainstream health podcasts are not necessarily oriented towards peptides. A lot of the stuff they talk about is kind of just like dangling carrots in front of people. Yeah. I'm like, Ooh, there's this, There's, this there this.
And it's cool to listen to. But in terms of like actually like implementable things that come out of that, I don't know how much there is. Whether that's by design or not, will leave that up for interpretation. Do you think it is because then they leave your stuff. There is no like mystery question. Well, that was obviously mystery and questions from myself. So I can't cover everything. That's been six plus years of me like refining, doing material. Yeah. So like, if you were to watch, like I hope my old YouTube channel does come back so people can go like go watch how bad my videos were,
to know that this is not like something that I just like popped out of the womb being able to do. But yeah, I would say I've refined that to the point to where it's, Like I got, that's what I figured out I was good at doing was like taking complex stuff and then putting it into way to like where most people can act on it. And I would say probably that becomes more of a threat than more like the passive entertainment content. So I don't say that in a way that like, I am not better than anyone believe me of, or anything, but that just, if I had to guess why mine gets criticized
so much, it's that and there's people out there that For whatever reason, really do not like us. And that's just the nature of when you put yourself out into the world, right? Like when go play Miami, there's going to be little eight year olds giving you the middle finger, you know, it's the team they're on. So you can complain about it or you could just keep on rolling. That actually happens. Well, I mean it happens when we play in Miami. I was just thinking about, uh, or nothing.
He would be one of those kids if he went to a Miami football game. What is best for high hematocrit due to testosterone use? Jim, I actually just made a video about this on my Spotify. Thankfully that is up still. If you go on Spotify, just look up my next to most recent episode. And I'll actually talk about hermetic crit on testosterone. Use short answer is like do cardio. Obviously that's going to help a lot manage the dosing frequency. So making sure that you're doing more frequent injections in a smaller dose. Um, and that usually for most people is going Do you recommend women give blood when on testosterone?
I would say absolutely not. What do you think? Yeah, I'd say no. Most women actually don't struggle with high hematocrit and hemoglobin on Testosterone. They just want to be a blood donator. Uh, I mean, you could, do you run into the issue of potentially, so here's what happens if you go watch the long form video I made on testosterone short way to explain that is that when you are taking testosterone, You basically create a cascade in your body that, when give blood,
it actually will lower iron and baritone even more because you're using exogenous testosterone. And so that's why I say people want testosterone they actually do more harm themselves giving blood. than people that are not on testosterone because of the feedback loop that you are creating in the body when you introduce it. So if you're somebody has to get like a blood fusion, like an emergency case or something who's on Testosterone, you get a flood infusion. Well, that would be accepting blood. Yeah. Like would that make a difference? So no, no. It's just that if your on testosterones and you were donating blood, yeah.
No, I get that. But no if need a blud transfusion or like extra like for every reason or an accident or What's up Shanna? She says, how often should I take injectable carnitine? Only two days. Um, yeah, I would say as much or as little as you want to. I usually do it three to four days a week. You could do every day, but then it kind of becomes like injection pain. Yeah. Like as a pre-workout. And if it's too painful, would use it for your pre workout.
That's going to be like your hardest like workout of like the week, like, so for me, for like me I always like using it on like leg days Cause I know that's my artists, like that space. I mean, I would use it every day, but I just don't feel like injecting it everyday to be honest. So just do it on training days. Usually. Thank you, Jennifer. The compliments on the space, hopefully it comes across cool. Hopefully quality is good. Uh, woman in our late forties still struggling with acne. Is that indicative of naturally high testosterone?
I'd say not necessarily. It could be a dietary, like a good dietary thing. Could be an imbalance of hormones too. Yeah. Like high androgen relative to estrogen could. Be gut issues could, be type of testosterone. I would say if this person's not on testosterone, it wouldn't be testosterone delivery issue. But yeah, could it be, a lot of things. Acne is so, so like tough for me. Cause like I'm so sensitive to acne when I was young.
Yeah. Emotionally, because it was like a very huge self image problem for me. And so I get it. Believe me, yeah. UTI helps with apple cider vinegar helps the UTA was the optimal ratio of estradiol to progesterone typically around four to one is what you're going to want to see. Obviously everyone's going a little bit different. Yeah, you do. Yes. Please make a pre-workout cheat sheet. I'm on it, How did I not think of that yet?
I actually have, but it's just gotta get around to it. How do I feel about HCG for life as a man on TRT? I think some guys probably need it. Some guys for like testicular atrophy, they feel a lot better with 250 IUs of HCGs, two times per week. So I thing it's dependent on the man. some people need and then some don't, some do worse on it, and some like how they don t feel. And then guys feel way better on. Then some, it doesn't matter, but I don' think there's an issue with being on life alongside of testosterone, especially if you do well with it And that's it.
Yes, Jenna, the picture behind us changes. It's one of those like picture TVs. Yeah. That's very distracting for me. I look at the painting techniques that they're using. But anyway, yeah, well, we're right at two hours and looks like that is all the questions. So thank you guys for an amazing Saturday morning. I hope you have a great pie day. Today's actually pie. You know why it's by day, but now I want blueberry pie who maybe you should, if it spy day 3.1415926535. Pi is a geometric term,
and it's 3.14. Basically, to get the circumference of a circle, you multiply the radius times pi, get this circumferences, then the area would be pi r squared. Or maybe I might have misspoken on that, so don't quote me to that. But anyway, March 14th is Pi Day because pi is 3,144. Yeah. So anyway. Yeah, so I hope you have a great pie day out there.
Go eat some pie. Take some Retta, eat a pie, take some metformin, go eat pie and enjoy. So that's it. Thank you guys so much. Just in closing, just know that we are so, so so grateful for everyone out there to get to do this for us is a dream come true and a blessing. And so wherever you are, thank you, whatever shape or form or fashion that you support us.