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Peptides for Injury Repair Heal Faster with the Wolverine Stack 20

2026-03-29 · 16:07 · 4 min read

If you've followed me for a while, you know about the Wolverine stack. BPC-157, TB-500, and a growth hormone peptide. Solid combo. But I've been experimenting and gathering feedback, and there are two more peptides I want to add that make a real difference for soft tissue healing.

Here's the updated stack and how to run it.

Who this is for (and who it isn't)

This stack is for soft tissue injuries. Muscle tears, sprains, strains, tendon and ligament damage. It works before surgery and after surgery. Sometimes it works well enough that you don't need surgery at all.

This stack is not going to help bone-on-bone injuries, herniated discs, or cases where the tissue simply isn't there anymore. Peptides can't regrow tissue that doesn't exist. Stem cells maybe, but that's a different conversation.

If you have an active soft tissue injury, keep reading.

How peptides actually work for healing

Peptides are short chains of amino acids that signal cells. The ones in this stack accelerate processes your body already does. They promote tissue repair, reduce inflammation, stimulate blood flow, and support cellular regeneration.

As we age, healing slows down. These peptides help bring it back up to speed.

BPC-157

The classic. Originally derived from human gastric juice, the version you inject is synthetic.

BPC-157 promotes angiogenesis, the formation of new blood vessels. That gets oxygen and nutrients to injured tissue. It also stimulates growth factors at the injury site and reduces inflammation.

Dosing: Inject subcutaneously at the injury site, not in the belly. 250 to 500 micrograms twice a day. I'd aim for 1 mg total per day for most soft tissue injuries.

Avoid IM injection unless you're comfortable with it, since you can bruise the area.

Cycle: Stay on as long as you need. If you pass 12 weeks and the response slows, titrate the dose up.

TB-500

This is the synthetic version of thymosin beta-4. It pairs beautifully with BPC-157, which is why the original Wolverine stack put them together.

TB-500 promotes cell migration to the injury site, supports blood vessel formation, and regulates inflammation. Especially good for muscle and tendon injuries.

Dosing: 2 to 5 mg per week, split into two or three doses. For an active injury, I crank it up toward the higher end.

If you have a 1-to-1 BPC/TB-500 blend, 1 mg of the blend works fine. But if you've got TB-500 by itself, I push the dose higher for injury purposes.

GHK-Cu (the new addition)

GHK is a copper-binding peptide with regenerative properties for skin and connective tissue. It's anti-inflammatory and antioxidant.

Where BPC and TB-500 handle inflammation and blood vessel formation, GHK boosts collagen synthesis. That's what rebuilds tendons and ligaments. It also modulates gene expression toward tissue regeneration.

Dosing: 2 to 5 mg per injection, subcutaneous near the injury site.

Here's the catch. GHK burns when you inject it. To deal with that, I dilute it more in the syringe. If my 2 mg dose ends up at 10 units on an insulin syringe, I'll add 50 to 60 more units of bacteriostatic water to that same syringe. It cuts the sting dramatically and reduces the welts.

You can also mix it with BPC and TB-500 to dilute the burn.

PEG-MGF (the other new addition)

Pegylated mechanical growth factor. A variant of IGF-1 that's particularly good for muscle and tissue repair after physical trauma.

PEG-MGF activates satellite cells, which are key for muscle regeneration. It also helps reduce scar tissue formation, so the repaired tissue keeps its strength and flexibility.

Dosing: 200 to 400 micrograms at the injury site, a few times a week.

This one doesn't sting. But because it's an IGF peptide, I don't mix it in the same syringe as the others. Also, you don't want to overload one injury site with too many injections at once.

Honestly, for pure injury healing, PEG-MGF might even outperform BPC-157 in some cases.

Growth hormone peptides (or HGH itself)

This is the systemic piece. Growth hormone supports protein synthesis and cell proliferation across muscle, cartilage, and connective tissue.

Options:

  • Ipamorelin: 200 to 300 mcg once or twice daily
  • Tesamorelin: 1 mg daily
  • HGH: 1 to 2 IU daily, I'd start at 2 IU for an injury

Ipa and Tesa stimulate your body's own growth hormone release. HGH supplies it directly. I prefer HGH for injury repair, but I know not everyone has access.

These all go subcutaneously in the belly. No need to inject at the injury site since the effect is systemic.

How they work together

Each peptide hits a different phase of healing.

BPC-157 and TB-500 handle the early stages. Inflammation, blood vessel formation, getting cells to the site.

GHK comes in for the longer build. Collagen, tissue strength, flexibility.

PEG-MGF supports muscle repair after trauma or surgery.

Growth hormone peptides put your whole body in repair mode and amplify everything else.

It's a one plus one plus one equals seven kind of effect.

How long to stay on

People always ask if they can just keep taking peptides through a long injury. Yes.

Take a torn ACL. That's a long heal. I'd run peptides the entire way. By day 90, you might not respond as strongly as day one. That's fine. Bump the dose up by 10 to 30%, week over week or month over month, and you'll get the same response.

I'm much less worried about building tolerance than I am about under-recovering. I'd rather titrate the dose than end up with an injury that nags me for life.

My take

The original Wolverine stack works. The updated version with GHK-Cu and PEG-MGF works better. For your average soft tissue injury that would normally take six to nine months, I think this stack can cut recovery time in half in the best case and 25% in the worst case.

For an athlete, that's massive. For anyone who just wants to get back to their life, it's just as big.

These aren't a replacement for surgery in every case, but a lot of times they can prevent it. And after surgery, they speed up the healing. Run them before, run them after, run them through.

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Full transcript click any paragraph to jump video

Hey everybody, this is Hunter Williams. I hope you are doing amazing wherever you're at in the world. Today's video is going to be the soft tissue injury peptide stack. So you may know this as the Wolverine stack, I'll actually probably call this the wolverine Stack updated or a Wolverines stack 2.0. Cause I've got some other things in there that I think just in my own experimentation and from feedback I have heard from other people that work really well. So basically let me explain who this video or a podcast will not be for is if you have a bone on bone injury into which there is no soft tissue or cartilage

or ligaments around the injury. Um, so basically I get people ask me all the time, like if they have herniated disc or, uh, bone-on-bone on their back or something like that. Peptides can not help you regrow tissue that is not there. So in a lot of cases, people may have an injury like that and really peptides aren't really going to do anything. Stem cells possibly, but a lotta times, unfortunately, I'm not someone that would ever recommend it. A lot those require surgery. What this video will be for though, is if you have any sort of soft tissue muscle injury, so muscle tears, sprains, strains,

any of those things, it should help. and it should help dramatically. And I'll say that you could do this before surgery, you can do it after surgery. It will help both. So a lot of times people ask me to like, should I do these after my surgery or before surgery? And I think the answer is both, I just think it drastically cuts down the healing time. That's what we're going to talk about today. Pretty simple, but I've got some updated stuff for all you athletes and high performers out there that may be dealing with an injury or something like that, that I'll think will be useful to you that haven't talked a whole lot about previously, at least in an organized form.

So that's what we're going to talk about today. Don't forget the peptide cheat sheet is always in the description of the videos. You can check out fully optimized health, the best community out there. And also too, if you ever have questions or suggestions, please leave a question in that box. I get all of those and I can't respond to everyone, but I do do my best to answer those in all the Q and A videos, so without further ado, let's jump to the slides and talk All right, I am Hunter Williams and this is the soft tissue injury peptide stack. So let's jump into it and go through what some of these peptides are and how they work.

Just as an overview, kind of like I mentioned, soft-tissue injuries encompass damage to muscles, tendons, ligaments, and other non-bony tissues in the body. They can result from a lot of things, oftentimes acute trauma, such as in training or an accident, repetitive strain, which often leads to pain, inflammation and limited mobility. For a lotta people, Um, that are active in training. Sometimes this is a cost of doing business as we would say. So, uh, when soft tissue damage occurs, the body initiates a bunch of processes that involve inflammation, proliferation,

and tissue remodeling. And, as, we age at any age, it's not always the most efficient, but as age it becomes severely or dramatically impaired. And then obviously depending on the severity of the injury, aging individuals have a slower tissue healing typically. So let's jump into some of peptides. On the whole, before we get to the specific ones, I want to explain what peptide do because a lot of people are confused about how they work. In essence, peptids are just small chains of amino acids that have various roles within the body.

And some of these include cellular signaling, which make them ideal for enhancing our natural healing response. So a lot of times people wonder, you know, like, are peptides pharmaceutical drugs? They can be, but not necessarily. A lot times it's accelerating natural process in the bodies that help the heal faster itself. So there are specific peptides we're going to talk about today that promote tissue repair, reduce inflammation, stimulate blood flow and improve cellular regeneration. So when we create a stack like this, we can accelerate recovery from these injuries and ultimately hopefully restore tissue function.

and possible minimize or avoid altogether long-term complications from those injuries, which I had definitely seen in my own life and the lives of people that I have helped and coached and whatnot. So first one, ah yes, BPC 157, the age old soft tissue injury peptide, but basically it's derived from human gastric juices. The peptides you inject is not from humane gastro juices, that's where this peptid comes from. It's one that is synthetically made. That's what it is basically modeled after, but it's well known for tissue protective and healing properties.

So it enhances angiogenesis, which is the formation of new blood vessels, uh, it was crucial for supplying injured tissues, with oxygen and nutrients. Uh, and works by stimulating the production of growth factors in these injured issues that you're injecting it into, thereby accelerating cellular repair processes. It also reduces inflammation and help protect cells from further damage, um, creating an optimal healing environment, I am of the opinion you should do it before surgery and after surgery. And sometimes if you do a before-surgery, you may not even need surgery, so I've seen that tons of times where people take PPC alone and it prevents them

and keeps them from having to have surgery So dosing wise, what we're going to do is at the injury site, not subcutaneously on the belly, but at injury sites, we are going administer it sub-cutaniously. Potentially you could do an IM2, I just don't want people to inject IM, potentially cause bruising, Either way, you could do 250 micrograms per day. Depending on the severity of the injury, I would do this realistically twice a day, so I'm pretty trying to get a total of one milligram per Day,

but I think that's a good starting point. So 500 micro grams in the AM and the PM should do a Good job of accelerating healing and then you can kind of titrate from there. As far as the cycle length, i would say you want to stay on this as long as You kind of need, sometimes you may have to titrate up the dose if it's past 12 weeks, just to make sure that it is still doing the job and your body hasn't built up too much of a tolerance to it. The next peptide is going to be, yes, the Wolverine stack TB 500 BPC 157 pairs nicely with TB500, but basically a synthetic version of thymus and beta 4,

which is a naturally occurring peptides. involved in cell repair and regeneration. So it's particularly useful for muscle and tendon injuries. Basically what it does is it promotes cell migration and aids the movement of cells to the injury site to initiate repair. Like BPC, it also enhances blood vessel formation and regulates inflammation, making it valuable for the early stages of injury recovery. Typically, depending on the use case, I would say two to five milligrams per week. If you have an injury, soft tissue injury split into two doses, And then you could continue, you know, add infant item as you need.

You may have to play around with the dose to get more of a response, after eight to 12 weeks or so. But, I like two milligrams, two to three times per week. It goes high as five milligrams. Again, have said this in videos before, but if you have a one-to-one blend of PPC and TB 500, You can just use that and just used one milligram of both. but I think if have TB500 by itself, I like for injury purposes to increase the dose. And that's what often too I talk about, you know, have on the peptide cheat sheet. You can use a lower dose and it works, but if you have a soft tissue injury, I really crank up a dose to like two to five milligrams per week total that

you're breaking up into multiple doses. So the next one is going to be GHKCU. GHk, the copper peptides is a copper binding peptid with strong regenerative properties. especially for skin and connective tissues. It also has significant anti-inflammatory and antioxidant effects, which aid in the wound healing and soft tissue repair. But basically, whereas TB 500 and BPC 157 work more on inflammation and angiogenesis, GHK improves collagen synthesis, what's essential for rebuilding tendons and ligaments.

So it also modulates gene expression to favor tissue regeneration, as shown in PROMIS, and reducing oxidative stress and inflammation. Um, but typical dose for tissue repair, um, or soft tissue injuries is around two to five milligrams. Uh, you can apply this topically, probably, I would say good luck finding a topical formulation that you could give that dose. That's affordable. Um. You could potentially make your own, But, Um I wouldn't inject subcutaneously near the injury. Now the rub or the issue with this for a lot of people is that it burns.

So say you have a bum shoulder and you could inject GHK into that shoulder. A lot times it can burn when you inject it. And so what I do to avoid this is yeah, you can mix it with BPC and TB 500 that will dilute it a little bit and potentially reduce the sting. But what like to do is Say I'm getting two milligrams. And for whatever I mix my water or my peptide with water, it ends up being 10 units on an insulin syringe. I'll take that, and then I will add 50 to 60 more units of water into the GHK in that specific syringe.

That will dilute it enough to where it won't burn as much when you inject it. Then you can potentially respond a little bit better and not have the burning or the welds that come from injecting GHk. So I wouldn't say it reduces it completely, but it definitely reduces a lot. But GHK, amazing. And again, all these works energetically. So the next one is going to be PEG-MGF. This is very, I would say in comparison to others, it is way lesser known for sure, but it's basically Pegolated mechanical growth factor is a variant

of IGF-1 that promotes muscle and tissue repair, particularly after physical trauma. So what it does is stimulates the repair and growth of muscle tissue by activating satellite cells, which play a crucial role in muscle regeneration. It also helps reduce scar tissue formation, ensuring the repair tissue retains its strength and flexibility. And what I would do is I will inject this 200 to 400 micrograms at the injury site. You could do it every day. I probably like a few times a week to do this just to allow more healing to go in.

This one doesn't sting or cause any injuries or anything like that, but I wouldn't because of this one being more of an IGF peptide. I wouldn't necessarily mix it with any of those others in the same syringe. And sometimes too, you just, if you have an injury, don't want to inject too much around that injury cause any sort of like irritation or reaction or anything like that. But I love PGMGF. It works really good with those other ones. You can even find blends with it being with BPC and TB 500. but I just have it, when I buy it I get it by itself and it works And I would say even,

uh, you know, it enhances VPC, but if you were to just use this, I think it may be even specifically for injury healing purposes, maybe even works a little bit better than BPC. So, and we have it from Maryland, test Maryland or HTH. Now I'm a fan of HGH itself, But I realized not everyone wants to do that or has access to it. I lumped all these together, but basically growth hormone-releasing peptides like IPA, TESA, or HDH are valuable for soft tissue repair as they stimulate the release of endogenous growth hormones or, in the case of growth, hormone itself, supply it directly.

Growth hormone facilitates, amongst other things, the repair of muscle, cartilage, and other soft tissues by promoting protein synthesis and cell proliferation. Ipa and Tesa are preferred for their selectivity. People would claim they have less side effects, I prefer to use HGH. So for IPA, you're looking at 200 to 300 micrograms once or twice daily. TESA I would do one milligram daily, and then HCH I wouldn't do 1 to 2 I use daily probably in the case of injury repair, I'd start with two I used and that would be for a man or a woman.

But for these you can just inject subcutaneously into the belly. You do not have to inject at the injury site. This is more of a systemic effect of helping the body repair on its own and when we elevate growth hormone levels typically we're going to repair and accelerate healing in a better manner. So those work wonders and again work synergistically with all these peptides. Let's talk about these synergies. When we look at all these, it's kind of like a one plus one, plus, one equals seven effect. So each peptide contributes to the recovery process by targeting, you know, a slightly different phasor aspect.

But we kind think of BPC and TB is the anti-inflammatory and promotion of new blood vessel formation, which is going to be crucial in the early stages of healing. GHK kind comes in for the long run to enhance collagen production, Which is vital for tissue strength and flexibility. The PEG-MGF supports muscle repair, especially after a traumatic injury or surgery. And then lastly, we have the growth hormone peptides to just basically enhance the body into a state of repair and regeneration overall, and then optimize protein synthesis and cell repair.

So we sum all of those up together. I've got the chart here. You can kind of see, I don't need to go through that, but before the Wolverine stack was, BPC, TB 500 and a growth hormone peptide. And I kind of just added in GHK and PEG into that. I would prefer HGH in the case of healing and injury. But I think if you look at your average soft tissue injury, so let's just say like your which may take six to nine months, depending on the severity to repair.

I think this could probably cut down the recovery time in half in the best case scenario and worst case, probably 25%. So you look at that, you know, go from six and nine to maybe three to four months of healing and that's massive, especially if you're an athlete. But I think for anybody that just wants to get back up on their feet, it's huge. So it was one of those things. These are all out there and available and people know they work. It's just probably never going to be propagated into mainstream consciousness because there's too much money in doing surgeries and things like that. And I'm not saying these are a replacement for surgery.

A lot of times they can be, but they aren't always. Like I said before, like in a case of a bone on bone injury, It really isn't going be worth it or not going do anything. That's it for the slides. And that is the soft tissue injury repair stack. So hopefully that was helpful to you guys. Um, it's pretty straightforward. And when we look at one thing I wanted to close out with is when you look cycling of this, a lot of times people will ask me for an injury, you know, how long can I use the peptide? Can I just keep taking it? And I think, When we look at the cost benefit analysis, right, of like, okay, I have this amazing peptide, but I don't want to stay on it too long,

or I want build up antibodies to it to have it not become effective. I'm of the opinion that say you have a torn ACL, that I would use peptides until that ACL heals, and that may mean I'd have to titrate up the dose to get the same response. So like on day 90 of my peptid cycle and healing an injury, probably not going to respond as well as day one. but what I can do is increase the dose, maybe by 10, 20, 30%, uh, you know, week over week, month over month, get the same response that would on day one. And I think if you look at the, like cost benefit analysis of doing that, I'm much less concerned about tolerance built up to a peptide,

or I could just increase a dose to get same effect. Yeah, don't want to do that for a lifetime, but at same time I would rather do than have to worry about potentially like limiting my recovery or even not recovering to the fullest and having an issue that nags me for the rest of my life. So that's just my thoughts. But hopefully that was helpful to you guys. If you have questions, comments, concerns, or anything like that, please post in the comments below. I do my best job to incorporate those into my Q&A videos, which leads me to remind you, don't forget to add your question down to that Q and A box and I'll make sure I address that in a Q & A video.

To close out, thank you guys so much. I am blessed and privileged and honored every day to get to do what I do. So even just from viewing this, like and commenting, subscribing, sign up for the email list, using my affiliate codes, any of that stuff to anyone's supports. Thank you so, much it means the world to me. And like I've said before, I take this really seriously, so promise to just keep getting better and keep bringing more and relevant content to you, guys. Much love and I will talk to in the next one. Peace.