The KLOW Stack BPC-157 TB-500 GHK-Cu KPV

0:09 Hey everybody, my name is Hunter Williams. I hope you're doing amazing wherever you are in the world. Today's video is going to be about the clow stack. So that is spelled K L O W. You may have heard of the glow stack, which is BPC, TB 500 and GHKCU, but the Clow adds one more into that and that's going be KPV. A lot of this, if you aren't advanced peptide user will probably be redundant. Excuse me, redundant, redundant and a little bit more elementary for you, but I think it will be beneficial nonetheless.

0:42 So what I'm going to do in this video is walk through each of those peptides. If we're being honest with ourselves, if we are going to do a blend of peptides and we know all those blends or the peptide in that blend work well together, why not put these four peptids together because the synergies are pretty amazing. I love using all these, I've used them all extensively in isolation and in combination and adding in the KPV to this absolutely provides even that much

1:16 more benefit to which we can actually use them all in one shot. And I think the more that we can minimize the amount of injections that do, I do think everybody would agree that's probably a good thing over time. So without further ado, All right. I'm Hunter Williams and today is all about the Clostax. So we're going to talk about some healing, longevity, and wellness with Clostat. Just again, to give you a brief overview of what it is, we have KPV. That's a new player in this one. KPB is a tripeptide derived from the alpha melanocytes stimulating hormone with potent anti-inflammatory activity that inhibits NF-kB.

1:52 and reduces proinflammatory cytokines without broadly suppressing immunity. We obviously have BPCM127. Everybody knows what that is, right? It's a 15 amino acid peptide from human gastric juice with remarkable healing properties that regulates nitric oxide systems and promotes tissue repair. You have TB500 aka thymus and beta-4 fragment. So TP500 is a synthetic derivative that orchestrates healing by regulating actin binding, cell migration and gene expression while reducing inflammation at the same time. And then we have GHKCU, the copper peptide.

2:24 It's a naturally occurring tripeptide that binds copper ions, modulates gene expressions and promotes tissue remodeling with significant anti-aging effects. So when we put these together, it creates a very synergistic effect that addresses multiple aspects of healing. Regeneration and longevity in the closed stack is increasingly popular in functional medicine and biohackers for its comprehensive approach to tissue repair and wellness in general. Let's look at KPV real quick. So it's a short tripeptide again derived from the alpha melanocyte stimulating hormone that retains potent anti-inflammatory activity without the other

2:58 hormone effects from this. It comes from a Melanotan family so it is very similar to Melantan-1, Melatant-2 and PT-141 in the chemical structure. So it works by inhibiting NF-kappa-B and MAP kinase signaling, which reduces pro-inflammatory cytokines like TNF-alpha and interleukin-6. And unlike steroids, it modulates the immune response without broadly suppressing immunity, dampening inflammation at its source, and it intercells via a peptide transporter, PEPT-1, in the gut.

3:28 reaching intracellular targets directly. It also may stabilize mast cells and exhibit antimicrobial effects contributing to its anti-inflammatory profiles. So the targeted action makes it valuable for treating chronic inflammatory conditions without compromising immune function. What are some applications? Obviously, it's very powerful in GI disorders or GI dysregulation, and you can take it orally or injected. Inflammatory bowel disease models, oral KPV significantly reduce colonic inflammation. because it promotes mucosal healing without the severe side effects of steroids.

4:00 Also in skin conditions in my life, I know that KPV has had profound impact on my skin, whether that's like breakouts with acne or even just, you know, red spots or whatever. So KPV reduces inflammation in psoriasis, eczema and dermatitis, helping to alleviate redness, itching and abnormal skin cell proliferation. And you could inject it or use topical or transdermal KPB in treating these long-term conditions. Then also too, what's pretty cool is neuroprotection. So emerging research suggests KP may reduce neuroinflammation. and protect neural tissue which potentially benefits conditions where the brain inflammation is a factor such as cognitive decline or neurological damage.

4:35 So by controlling chronic inflammation, KPV could help mitigate inflammation aging, which is long-term low-grade inflammation associated with aging and degenerative diseases. Its role in maintaining gut integrity also has systemic benefits that potentially improve metabolic health. So we look at any scientific evidence. Obviously, there's not going to be a ton of published studies on these for obvious reasons. But we do see that it has a favorable safety profile with no significant toxicity or immunosuppression. And there are tons of anecdotal case reports.

5:05 So if you're taking orally, one to five milligrams per day is good. Oops, I think I meant to say one, two, five grams because I know well, no, that's actually right. Sorry. So scratch that. But if we're taking orally one to five milligrams per day for taking subcutaneously 200 to 500 micrograms per. Day, i've gone all the way up to one one milligram injected, but I. Think five hundred micro grams a day is enough for most people. Topically, we can do 0.01 to 0,1% concentration and cream your gels.

5:35 And some people do use this as a nasal spray. I actually haven't personally done that yet, but I'm sure it's better than nothing, probably not as good as injected. So it typically used daily or nearly daily for several weeks to months when treating chronic conditions because it is derived from a natural human peptide. Even moderate doses have not shown any significant adverse effects. Unlike corticosteroids, it does not cause immune suppression, tissue thinning, or hormones. disruption. So let's look at PVC real quick, because I know you guys probably know a lot about that. But just for refresher, it has a pleiotropic regulator of healing.

6:07 It's a 15 amino acid peptide, originally isolated actually from human gastric juice. so it's known for its remarkable healing and cell protection properties. it acts as a regulator for healing, which influences various signaling pathways. Also works on nitric oxide system effects, so up regulates endothelial nitrous oxide synthase, otherwise known as ENOS. It boosts inner production in blood vessels and this leads to improved microcirculation and angiogenesis at injury sites, which is why it's such a popular peptide for healing.

6:37 And then we look at gene expression alteration. It also is an expression of genes like VEGF, EGR, and SRF involved in angiogenesis. it also helps with cytokine regulation and tissue regeneration and orchestrates a pro-healing environment. It's a highly systemic peptide once administered sub-q, it's distributed widely throughout the body, then minimizes injection, and it remains effective even getting orally as a stable gastric juice. And you have to do some things to that, but obviously the injection will always be the best route to take it. So when we look at the therapeutic effects, we've got musculoskeletal healing, organ protection, anti-inflammatory and pain relief,

7:12 GI protection. Again, a very, very versatile peptide to say the least with BPC 157. Also too, I did want to put this in there that Bpc has neuro protective effects. So in rodent studies of stroke treatment with bpC improved recovery with better motor function and memory, post stroke, and reduced brain inflammation compared to untreated controls. In traumatic brain injury studies, BPc reduced a brain edema, which means there was less bleeding and increased survival rates. They're intriguing findings that BPC interacts with neurotransmitters and it might normalize overactive dopamine system behavior in certain brain disorder modules.

7:49 So the neuroprotective and neuromodulatory effects demonstrates that BPC can be used probably for concussions, neuropathies, or even mood and cognitive disorders. But we don't have data on that. I know in my case, I think the Bpc 157 improves my mood. So I don' know if there's a lot of other people out there that would say that, but in me it has. And I also suffered a lotta concussion when I was younger, so there may be something going on there too. It also works to repair tissue. There's also cardiovascular benefits. So, pro-angiogenic effects can help counter age-related microvascular decline and its cytoprotective actions may prevent cumulative damage in organs.

8:27 And like I said, we have cognitive preservation. BPC preserved cognitive function in scenarios of brain injury or toxin exposure by reducing inflammation and enhancing healing. Also, there are a lot of people that use BPC preventively to help bulletproof their body against wear and tear. It's really good to just help with recovery from training, things like that. And there no human studies really that we have on it yet, other than the millions of that have been using. So there's very limited data. Obviously, it's kind of funny I put this in here.

8:58 There's no human studies on it, but it is banned by WADA. So even though we don't know anything about it from a study standpoint, they knew enough to ban it which they did because it actually works. Common dosing protocol 250 to 500 micrograms once or twice daily. Taking the capsules, kind of the same thing. I'd say you can probably go up to like two milligrams with the capsule per day. Then four to 12 weeks, depending on the condition, I always tell people you can use it as long as you need to help heal the injury. So it's not FDA approved in case you were wondering.

9:28 Now we have TB 500. Synergistic obviously with those other two. It's a synthetic derivative of thymus and beta-4. If you ever see that, that's what that means. which is a 43 amino acid protein vital for tissue repair and regeneration. So it mimics the effects through two primary mechanisms, one being the actin binding and cell migration. It binds to G-actin within cells, which regulates actine polymerization and cytoskeleton dynamics. This enhances cell motility, allowing cells to migrate to injury sites and begin repairs.

10:01 Then we have gene regulation and anti-inflammatory effects. So it influences numerous signaling pathways, suppressing key inflammatory cytokines like TNF alpha and interleukin six, and it modulates the NF kappa B pathway. So, it acts systemically to promote regeneration by setting in motion a cascade of events, basically new blood vessels form, cells migrate to the injury site, inflammation is controlled, fibrosis is reduced and stem cells are activated. This multi-prong mechanism makes it a very powerful healing agent.

10:31 So helps with wound healing. So in chronic wounds, ulcers and venous stasis ulcer, it has been shown to speed up healing with better tissue quality at the injury site. It's also been shown to help in eye injuries through healing the cornea. Also helps in musculoskeletal repair, so it promotes regeneration of muscle fibers and activation of satellite cells. And it also helps with cardiac regeneration, I think much more so than BPC, in my opinion, from what I've seen. So it improves heart muscle cell survival, activates cardiac progenitor cells and enhances angiogenesis after.

11:05 Heart attacks, it also stimulates epicardial cells to become new heart muscle or vessel cells, which potentially reduces heart failure risk. There's also some evidence to show that it reduces neuroinflammation, protects against sepsis and improves lung healing as well. So we have the stem cell activation, improved circulation, cellular protection and balance repair. TB500 obviously another great regenerative peptide. When we look at dosing, you can really dose this one for one with BPC. And obviously if you're using a blend of the clove, that's what you would be doing.

11:36 Some people like to do this loading phase of two to 2.5 milligrams injected twice per week. I've done that before. It definitely helps. The higher the dose more, but in a lot of cases you might not need that high of a dose. Then you could do like a maintenance phase. But I would say you also could just use 250 to 500 micrograms and use it in the one-to-one ratio with the BCC. In the case of the CLO, you're really going to be doing a one to one ratio of BPC, TB 500 and KPV. And then the GHK is going be the one that you would use a little bit higher dose for. So let's look at GHk.

12:07 GH K is a naturally occurring tripeptide. that binds copper ions with high affinity, so it was first discovered in human plasma and our levels significantly declined with age from about 200 nanograms from milliliter age 20 to about 80 nanigrams milliliters by age 60. So it can broadly modulate gene expression and cellular behavior, especially in the context of injury and repair. It orchestrates the removal of damaged tissue in a laying down of a new matrix. And then it also at very low concentrations, it can up regulate growth factors like BFGF and VEG-F in skin cells, which promotes angiogenesis and blood

12:42 flow to injured tissue. And it acts as a chemo attractant for macrophages, mast cells and capillary cells drawing the cells into wound areas. So pretty cool. Let's look at some mechanisms of GHK. One works on tissue remodeling. It stimulates the synthesis of collagen. glycosaminoglycans and other extracellular matrix components by fibroblasts. It also activates metalloproteinases that break down damaged proteins while increasing anti-protease levels to protect newly formed proteins. It also does have an anti-inflammatory and antioxidant oxygen, so it suppresses NF-kappa-B activation and reduces the secretion of inflammatory cytokines

13:20 like TNF-alpha and interleukin-6. It's also acts as a free radical scavenger and boosts antioxidate capacity by increasing levels of superoxide dismutase and glutathione. But you probably might not have known, I didn't know that until I was putting this video together, that it also boost glutothione levels in the body. It's cool about GHK is it influences expression about 32% of the human genome, which it activates genes associated with tissue regeneration and antioxidant production, while turning down genes linked to inflammation and tissue destruction. Just kind of coming in on, coming into the body, going into our DNA, turning on the genes that we need, and then turning the ones that don't.

13:56 And then it acts as a delivery molecule for copper, ensuring it's at the right place at right time, helps prevent accumulation of misfolded proteins by modulating copper interactions and keeping copper in a bound useful form. People ask me all the time about GHK and copper toxicity, you would have to take a whole heck of a lot of GHk. So typically a bottle of ghk minimum is kind of 50 milligrams, You would be needing to do a full entire bottle GH k for months on end to ever even reach the topic of copper Toxicity based on the research that I've done.

14:26 We look at applications that have skin rejuvenation, reduces wrinkle depth and fine lines by boosting collagen and elastin, also improves skin conditions and reduces scar formation. Helps with tissue repair, so accelerates the healing of burns. It also helps with corn ligaments, it's been shown to help with ACL reconstruction. and also benefit the rest of the connective tissues in the body. This one, as opposed to any of other peptides, also helps with hair growth. So it's the active ingredient, a lot of hair tonics that stimulate follicle growth, and a small trial found that copper peptide solution increased hair

15:00 density in men with androgenic alopecia comparable to monoxidil. If you don't want to inhibit DHT even the way that monoxide does, which is a little bit more tolerable than from Nasteride, use GHK because it is shown to do the exact same thing. but you're benefiting your body as opposed to inhibiting a hormone. We also have anti-inflammatory therapy. So it's been shown to help with COPD or emphysema models by reducing lung, lung destruction and inflammation, and also de-increase or decreases pro-flammatory

15:31 cytokines and improves lung histology, suggesting they could help lung conditions. There's also a cognitive benefit to GHK. Preliminary data suggests GHk might improve cognitive function and aging. A study found that old mice given GH K experienced partial reversal of cognitive impairment probably through epigenetic modifications and the reduction of neuroinflammation. It also influences pathways related to memory and synaptic health, although the exact mechanisms are still under investigation. Because GHK levels drop with age, endogenously, it's hypothesized that some aspects of aging could be due to this decline,

16:03 and supplementing with GHk might reverse those. So it addresses a ton of the hallmarks of ageing, the loss of collagen, increased inflammation, extra oxidative stress, and the reduced capacity to regenerate naturally. So when we use GHK is going to induce a more youthful state in the body. When we look at dosing, typically it's one to two milligrams per day. It could really go up to like three to four if you needed to. The problem with GHk injecting them, it can be quite painful sometimes. Now the good thing about the CloBlend is that the BPC and KBB and TB500 make it less painful.

16:36 They make a pain less? No, they do make less pain. There is a little bit more human data around it. One human study found that JHK cream increased skin thickness and reduced wrinkles compared to placebo. 12-week study when women with photo-age skin showed improved skin laxity, clarity, and fine lines with histological analysis confirming increased collagen and dermal density. So, JHk very well tolerated other than the fact that it stings. Now, let's talk about some of the synergies. So when we combine all these together, one, the biggest thing is going to be the reduction of inflammation.

17:08 Now this could be inflammation at an injury site or it could just be general inflammation in your entire body. So all four peptides have anti-inflammatory actions via different pathways, yielding additive and synergistic effects. So KPV inhibits NF kappa B, BPC modulates nitric oxide signaling, TB 500 suppresses cytokine release, and GHK scavenges free radicals. We're attacking inflammation from very different and very synergic pathways. It also is going to accelerate tissue repair. This would be a great peptide to inject near a soft tissue injury, if you have one more so than just Bpc and TB500.

17:44 So each peptide facilitates different stages of tissue repair. So BPC-137 mobilizes and starts the repair, TB-500 drives tissue construction at the repairs site, GHK optimizes the healing environment, and KPV ensures inflammation stays controlled at injury site. It also creates a balanced healing enviroment. When we look at creating environment, we want to like basically clean our room, right? We want like create a clean room for the body to do what it does. If you have a bunch of junk in a room it can kind of be hard to get the work done that you need.

18:14 So I like to keep my room clean. So users report dramatically reduced swelling and pain and injuries, faster recovery and improved overall wellness. And then last, but certainly not least, there is a synergistic anti-aging benefit. So even if you're not necessarily hurt or experiencing pain in a certain region of the body, The combination addresses chronic low-grade inflammation, which causes aging and supports tissue maintenance and regeneration and may have synergistic effects on the immune system, potentially bolstering resilience against infections or stressors.

18:44 So it's often nicknamed, you know, the wolverine stack. I think this would probably even be better than what would be called the Wolverine Stack. We look at practical applications and some tended injury models, PPC alone reduced recovery time by 80, up to 80%. So the full close stack may provide even more dramatic healing acceleration. I would virtually, I mean, you can't guarantee anything, but I'd virtually guarantee control to, or compared to placebo, when you control for this, your absolutely going to speed up the healing time. Typically, you're going to use this for four to six weeks.

19:15 I always say too, four, six, weeks is a good start. But if you have like a torn ACL, the torn knee, torn shoulder, or torn labor, anything like that, You really want to stay on this until it's at least almost all the way healed. And again, GHK alone can significantly affect around 32% of the genome. And then it's also been shown to reduce infections from wounds by up to 27%. So when we talk about this, it can be used for a lot of things. It can use for injuries. You can used it for chronic inflammation in the body.

19:45 Can be use it with someone with autoimmune disease. There's a ton of different things So we don't really have any studies on this. I think that where we go from here is obviously more people in the world using this and then if we can get some of these peptides I, think if, we look at a stack and we, look, at novel delivery mechanisms this could be one that is put into a buckle strip that you could take orally on a lozenge. This could probably be 1-2 that at least able, based on the structure of the molecules, able to be put in something that is not necessarily an injection.

20:18 Is the injection going to the best delivery mechanism? Yes. But I think to expose more people to this, we already know that KPV works orally. We already knew that VPC can kind of work oraly. Same thing with TB500 and GHK. So it's just a matter of more getting exposed to these to help drive awareness for them. There's not a lot of like quote-unquote scientific research around these specific peptides because of the nature of what research needs, which is funding to be able to take place.

20:48 But when we look at this, it's very versatile. There are so many different use cases for the Clostac. And I think everyone should be exposed to this. If you've been using the clostach or even if you're just using VPC and TB 500, I highly recommend this because again, It's like a one plus one, plus plus one equals 10 effect. I wanna make sure I said four ones. So that's it for the slides. That is it, for The Closed Stack. Now, there was one slide in there that I didn't put and it was intentional and, it the dosing, right? The reason I put that in, is because there's a lot of different research companies making a lotta different concentrations or formulations of those.

21:23 And I don't know what time this video will air, relative to when BioLongevity has this available. But, if I were making this on my own, this is what I would do. I would have 50mg of GHK, I'd have 10mgs of TB500, 10 mg of BPC, and 10 mgs KPV. I mix all of those into one vial with 3ml of bacteriostatic water and then I take 10 units of that per day. So what that ends up coming out to be is somewhere around the neighborhood of two milligrams of GHK and 500 micrograms of each of the other ones.

21:58 So I think if you were making that on your own, that's kind of a dosing you would want to do. You could obviously go higher, but I Think once daily would be a really good dosage for all of those. I didn't put that in there because there's not really like a standardized vial size of these that are coming out yet. But if you were making it on your own, I would do 500 micrograms of KPB, TB 500 and BPC 157, and I will do 2.5 micro grams of the GHK. Do that daily and you will be well on you way. So appreciate that one. I think this one is definitely going to be something over the next 12 months that really takes off because the synergies between these are,

22:32 again, the sum of them is, they, total is greater than the some of parts. Think I said that right. But anyway, I appreciate you guys, if you have experience using the closed stacks, and I've been getting tons of emails from people that have, they're like, oh my goodness, this is the most amazing thing ever. Leave those down in the comments for people so that other people can see that it is real world. We are human studies, as I say sometimes. So check that out, leave comments. And to everyone out there, thank you so much. I am so blessed and privileged to get to do what I do every day, And that is thanks to you, guys. Without you guy, without the viewers, Without the support, i don't exist.

23:06 Again, thank you guys so much. I always say, like everyone that's watching these and involved this, you are part of the movement to change the world and bring these therapies to the word, to help the work heal. So again, I just have so gratitude from the bottom of my heart for you, guys. That's it for this one. Thank you so guys much, help support the channel, do all that good stuff, and I will talk to you in the next one, peace.