This Peptide Reverses Pancreatic Aging (Pancragen Deep Dive)

0:09 Hey everybody, my name is Hunter Williams. I hope you're doing amazing wherever you are out in the world. Today's video is going to be about a little known peptide by a regulator known as pancreagen. So this is actually a peptides that works specifically on pancreatic tissue to help it become more youthful or to mirror or change it into a more the youth full state. This is part of a broader series of videos that I'm going be doing. Over the next few weeks that I've been doing for a couple weeks now about the injectable peptide bioregulators.

0:39 Obviously we have the oral versions of the biiregulator which work great. The injective ones are actually much stronger because obviously there is a higher bioavailability from the injection. So today's all about pancreagen and more or less the TLDR on this would be the pancogen helps mimic a more youthful pancreates. Now why is that important? Our pancrias obviously is related to insulin function and how well we produce insulin and our insulin sensitivity. So if we can reverse the clock on our pancreas, it's going to do a lot of good for the body from an inflammation standpoint.

1:13 That's what today's video is going be about. If you want the cheat sheet with the dosing for pancreatin on it, you can check out the pep-pad cheat down in the description. along with all the other peptide dosing that is on that sheet. And then as always, check out Fully Optimized Health, the best community on the planet where we talk about this, but I'm excited for this one. It's going to be good. So buckle up, strap up and we are going dive into pancreagen today. All right. I am Hunter Williams. Today is all about pancreagen, the pancreatic bioregular peptide. So let's look into it. Just to give you some background on what pancogen is.

1:44 It's a tetrapeptide, which basically means four amino acids. And you would think tetrah sounds like three, but it's actually four. Four amino acid with a sequence lysine, glutamic acid, aspartic acid and tryptophan. You see the molecular weight and formula there. The bioregular peptides tend to have a little bit smaller of a molecular weight because they're smaller, but it targets the pancreas specifically. It's also distinct from pankrogen, which is an unrelated DNA diagnostic test. So if that's what you're looking for, you got the wrong video.

2:16 but it's been available in Russia forever and it is used as an adjunct therapy for chronic pancreatitis, type 2 diabetes and age-related metabolic disorders. It's a synthetic analog of naturally occurring peptide isolated from bovine pancreas tissue designed to support and restore pancreatic function. So if you're new to the bioregulator space, basically what bi regulators are, is in Russia, what they were able to do is isolate tissue from pigs and cows, much like we take desiccated thyroid or desicated liver extract.

2:47 What they would do, is isolated tissue, from these animals and then pair them with some unique delivery mechanisms to help the body absorb them to actually work on that target tissue in the human body. So a lot of times we're talking about taking bovine pancreas tissue enhancing that with, some absorption ingredients and then using that to actually help the pancreas in the human body function better. So whatever the bioregulator is, typically that's what's going on. Let's look at the mechanism of action.

3:17 It works at a molecular level by integrating cells and penetrating the nucleus of the cells. Once inside it binds to chromatin. Most of bi regulators do this, so this is not unique to pancogen. If you're watching this series of videos, you'll probably pick up that common theme. But what it does is it interacts with DNA and histone proteins to alter gene expression patterns. So when we look at molecular modeling and biochemical studies that show this tetrapeptide, it binds to specific nucleotide sequences in the DNA with a preference for certain motifs like GGCAG in DNA major groove.

3:49 That's a fancy way of saying is basically when we inject this peptide, it's going into the nucleus of the cell and actually interacting with the DNA inside the cells. So this loosens the local DNA double helix or influences transcription factor binding, which upregulates the transcription of certain genes. And in this case, what we want to do is up regulate the transcriptions of more youthful genes within the pancreas. Let's look at this. This is kind of what would call epigenetic modulation. So basically it acts as an epigenetic switch that modulates chromatin state and gene activation.

4:22 So research shows that it binds to demethylated age-related regions of DNA, protecting them from damage and facilitating transcription. binds the DNA, it binds, the binding leads to loosening of chromatin structure and the chromatid decondensation. And then what that does is changes the gene expression, which leads an increased transcription of pancreatic differentiation genes to a more youthful state. So basically, that's what's going on there.

4:53 If you had a story to tell, and we're on the magic school bus of where a pancreagen was going, Shout out to all the 90s kids with the magic school bus reference. Hopefully you enjoyed that as much as I did back in the day. But let's look at the effects of pankrogen on the pancreatic beta cells. So this is where it's really gonna kick in a gear. At the cellular level, pangrogen enhances beta cell function in endocrine pancreas, so it increases insulin gene expression and insulin secretion capacity. We'll talk about why that's important. It acts as a mimetic of insulinotropic peptides by stimulating insulin release.

5:28 So this normalizes insulin production by restoring beta cell health. It raises serotonin levels in the beta cells, which acts as an autocrine signal to enhance insulin secretion. And it upregulates key transcription factors known as PAX6, NKX2.2, and PAx4 in isolate cells. But we see it's working actually, I'm going to talk about this a little bit, very similar to how GLPs are working. And I think this could be a really good adjunct to GLP's to not only to work synergistically for fat loss, but also to help restore pancreatic function

6:02 because a lot of people that are diabetic or pre-diabetic have pretty bad pancreatic function. So let's look at this effect on the other pancreatic cells. So, it also works on the alpha cells, so pankrogen helps regulate alpha-cells via factors like FOXA2 and PAX6 in KX2.2, which govern alpha cell differentiation. So it normalizes regulatory pathways to reduce excessive glucagon release that often accompanies diabetic insulin deficiency. And it also works on the acinar cells, if I'm producing that right, which are the exocrine pancreas.

6:34 So it increases PTF1A expression, Which is a transcription factor essential for acenar cell enzyme production in age cell cultures. It also restored Ptf1a levels around sixfold back to youthful levels. Which was pretty cool. And I thought this was cool because a lot of people suffer from this and they don't realize it, but they suffer form a digestive enzyme deficiency. Pancrogen helps promote digestive enzyme output and improve digestion in those with pancreatic insufficiency. So basically by upregulating acinar differentiation markers, pancogen revitalizes the extra-grin pancreas, improving nutrient absorption and reducing symptoms

7:10 like bloating or maldigestion in chronic pancrititis, which is pretty cool. Now, let's look at the anti-apoptotic and pro-proliferative effects. So, pancreagen provides cytoprotection, otherwise known as cell protection, to pancreatic cells by increasing levels of MCL1, which is an antiapoptoic protein. It decreases P53, a proapopathotic protein and is in essence associated protein, and it boosts cell proliferation markers PCNA and Ki6-7. The most pronounced increases reserved were observed in mature adult pancreatic cells, but even in very old cells pancreas causes significant uptick in

7:47 these markers. So basically what we are seeing there is the, again, return to a more youthful state by doing those things. It actually is reverse aging the pancreatic cell, which there's not a lot that we can look at that's doing this. Definitely not GLP-1s. The GOP ones are obviously helping the body, but they're not having these profound effects. So let's look at what it's doing to blood glucose regulation. In studies, it demonstrated glucose-lowering effects in diabetic animals and humans. It enhanced insulin secretion and sensitivity while moderating glucagon.

8:20 And it normalizes fasting insulin and C-peptide, indicating healthier pancreatic output. So researchers have described pancreatic effects as more physiologic, striking the very heart of what causes elevated blood sugar compared to standard hypoglycemic drugs. So again, whereas, and again I'm a proponent of metformin, met formin will lower your bloodsugar. Berberine will, lower you blood-sugar. Gardians will. Lower your, blood, sugar. Pancrogen will lower your blood sugar, but it does it because it's restoring pancreatic function, not because is doing something downstream to help lower

8:54 the blood Sugar, which again is more or less not that I wouldn't recommend using those things, But more less is not addressing the root cause of the issue, I also want to talk to the fasting insulin because fixing your fasting blood sugar is great and you can fix a fasting, blood, sugar with medication. But a lot of times it won't necessarily fix fasting. Insulin levels. And if you're fasting butter is an 88, but you are fasting Insulina is a 22. What that tells me is that the body is having to pump out massive amounts

9:28 of insulin to try to bring your blood sugar down. Whereas if your fasting insulin was like a two or a three, what that tell me, is the insulin is working very efficiently at the cellular level and your body's running smoothly. So I just want to throw that into, because a lot of people don't understand that blood trigger rises can be transient, but fasting insulins is like, a better reflector of what's actually going in the bodies. I wanted to throw this in because in the research, it's pretty cool that you see this insulin sensitivity and melatonin link. So in elderly diabetic patients, pancreas led to lower insulin levels for the same glucose control, reflecting improved insulin.

10:02 Sensitivity. so an interesting connection exists between pancreatine and Melaton regulation. Patients with type 2 diabetes often have blunted nocturnal melatonin secretion because of their insulin resistance. So as if you didn't need another reason to make sure that you weren't insulin resistant, it affects your melotonin production, which will affect while you sleep, then creates this vicious loop over time of what came first, the chicken or the egg. And then before you know it, you're in this battle where you can't sleep. You can lose fat.

10:32 So pancogen therapy in diabetics improved glucose and insulin profiles and had a direct effect on melatonin signaling. So rather than that negative feedback loop, this creates a positive feedback, loop which means that improved insulin function leads to normalization of melotinin function, which leads further metabolic improvement because you're actually getting deep sleep, Which makes sure that you lose fat more, that your have better energy, and so everything starts to get better. It's pretty cool that we can use one little bi-regular peptide to help restore pancreatic efficiency and pancreatic function,

11:04 which then improves our sleep and then it improves everything else because we're sleeping better. So I thought that was pretty cool. I wanted to include it, that it was kind of a windfall of using pancogen. It was not an intended effect, but in the studies when they've done this in Russia, they saw it. Looking at some additional physiological benefits, it alleviates symptoms of exocrine pancreatic insufficiency, which is common in chronic pancreasitis. It boosts enzyme output to normalize digestion and reduces issues like bloating, abdominal discomfort, and fatty diarrhea. So I think anyone that has dealt with digestive issues obviously have talked a lot about what you can do to help with your digestion issues.

11:38 Pancrogen would be a really good and affordable way to also attack that from another angle. It also has anti-inflammatory effects. So the gene regulatory profile suggests anti inflammatory effects in the pancreas. The increase CD79 alpha expression in pancreatic cells potentially improves local immune function and it may lower the risk of immunodeficiency and neutralize risk type one diabetes, which I thought was very interesting. I think this would probably, I mean, not telling you what to do, but I'm not your doctor but this will probably go well with someone with type 1 diabetes.

12:11 We can look at vascular protection, so it shows protective effects on blood vessels and diabetic rats. It normalizes capillary endothelial adhesion properties, and it prevents abnormal increases in leukocyte adhesion to the endotherium. So basically what that means is our vascolar networks and how we move blood around the body are going to be that much better, which again, what becomes impaired as people become fat and become insulin resistant, their ability to move, blood which eventually leads to heart attack and stroke. Basically, the endothelial protective effects could help reduce long-term diabetic complications like retinopathy, nephropathy and neuropathies,

12:44 which stem from capillary damage. So I think anyone could ask all the time, what's the best peptide for diabetic neuopathie, pancreagen could be something that you probably haven't looked at yet. Let's look at this application of type 2 diabetes. So it's prominent, most prominent investigative use is an adjunct therapy in type two diabetes, so it improves insulin secretion and reduces insulin resistance at the same time. It lowers elevated blood glucose while normalizing insulin dynamics in the body. I think that would be a good book title to help with fat loss would insulin dynamic.

13:15 In elderly diabetic patients, it significantly improved glucose tolerance and reduced fasting glucose, and it also simultaneously lowers circulating insulin levels toward normal, indicating improved insulin sensitivity. We can also look again at the exocrine support, so it supports the excretion function of the pancreas in chronic pancreatitis and other causes of pancratic insufficiency. It also promotes enhancement of digestive enzyme synthesis by pancreatic cells, normalizes digestion process, like I said reduces bloating,

13:45 stabilizes weight, stimulates viable acinar tissue and possibly aids regeneration of new aciner cells that helps preserve pancreatic function in pancretitis. It's often given during remission phases or of, or excuse me, after acute pan creatitis episodes to accelerate recovery. And it also is recommended to protect the pancreas from toxins like alcohol, drugs, or other toxins that may do it. And also helps the organ detoxify and resist injuries. So it's not a replacement for digestive enzymes or insulin, but it definitely will help along those things.

14:17 Now we can look at this. There is definitely an anti-aging effect to even someone that would be healthy. but is deeply tied to this whole bioregulatory slash gerontology thing which is anti-aging. So significant age-associated changes. Olden individuals often have impaired glucose tolerance and the subclinical pancreatic insufficiency is common even without overt diabetes. That's just something as people age, we become less and less efficient as this. By age 50 to 60, a large fraction of people have some sort of pancreatic functional abnormalities, which I think this should be a staple.

14:48 Let's look at some clinical use. In Russia and Eastern Europe it's been used for a long time, again for chronic pancreatitis. Also too I wanted to throw in here Superfort is the oral form slash the Oral Bioregulator for the pancreas and I would absolutely recommend you take this and then pancogen would be the synthesized injectable form. So when we pair those together, you're gonna get definitely like a one plus one equals three effect specifically on the pancreas. Also is going to be prescribed for people with diabetes and it is positioned as a supportive biomodulator, not a replacement for critical therapy.

15:19 So here are some preclinical studies. In 2007, they did a rodent study where they treated with pancreatin orally or intramuscularly. They found that oral pancretin produced a pronounced hypoglycemic effect, meaning that treated diabetic treating treated diabetic rats had significantly lower blood glucose levels and then pancreagen given intramuscularly normalized the adhesion of endothelial cells and mesenteric capillaries of diabetic rats and so pancogen prevented abnormal adhesions without making vessels abnormally leaky so it's actually working selectively to be even that much more efficient.

15:54 Another 2007 study in rodents found that normal pancreatic tissue with intact isolates and acinar structure, and then they looked at diabetic pancreas. So they had diabetic control rats that showed pancreatic islet shrinkage, beta cell loss and aciner degeneration. And then the pancrogen treated cells. In pancuragen treated diabetic rats, the pancreas was markedly preserved with larger isolates and better retention of acine tissue. It showed the Pancuragen prevented or reduced destructive changes in the pantreas under diabetic conditions, reinforcing that it protects and repairs pancrotic

16:28 tissue Let's look at a monkey study. In 2015, they did a study on it with nine elderly monkey females that were around 20 to 25 years old with age-related impaired glucose tolerance, and they were divided into five. Five of those received pancreatic injections and four received glymparide, which is a diabetes drug and both treatments lasted 10 days with metabolic measurements taken before, during and after the treatment. And the outcome was, that pancreas treated monkeys showed a decrease in basal blood glucose levels, glucose tolerance improved,

17:03 they could handle a glucose load more normally after pancreatin. The other monkeys that were treated with the diabetes medication similarly had to reduce glucose as expected from the drug. But what did pankrogen do that was above and beyond? So pancrogen normalized insulin and C peptide levels in the age monkeys. So after panchrogen, insulin, and c peptides levels were appropriate, lower baseline, properly responsive during glucose challenges. The monkeys that were just given the glima paride, which is the diabetic drug, ended up with elevated C-peptide and continued disruptions in insulin.

17:34 Pretty cool. Again, sometimes diabetes drugs are just masking the problem, whereas this is helping restore a more youthful pancreas. So after 10 days, the effects persisted for several weeks in the monkeys, which shows that it could have lasting improvements rather than a fleeting drug effect and no adverse effects were observed in animals. They concluded that pancreatin is effective and safe for correction of age-related imbalance of endocrine pancreatic function and can be used for LOE patients with impaired glucose tolerance. Again, I think we look at bioregulators and which ones we should use.

18:07 They can be very, very beneficial to help basically restore a more youthful state across the body. So this was a cell culture study. They took pancreatic cell cultures at different ages, early passage versus late passage to mimic young versus old cells, and treated them with pancreagen. so they measured the expression of multiple transcription factors governing pancratic cell identity. And what they found was that pancreatin significantly increased the expression of all these differentiation factors in both young and age cell cultures with especially large increases in the age cells.

18:38 So these changes essentially reversed the aging decline in those critical proteins. They also used a control peptide of bronchogen, which is for the lungs to show specificity and broncogen had minimal effect on pancreas markers, whereas pancrogen had robust effects. Another validation there that these are working specifically on the tissue. Whereas if you wanted to look at lung tissue, pancreagen probably wouldn't work but bronchogen would. So we see there, it affected both the young and the old, but the effect was much more pronounced in the older ones, which I think too is relevant to know if kind of extrapolate that. When looking at bioregulators, if we have a strappingly healthy young 21 year old male, is he necessarily going to feel anything or notice anything?

19:17 Probably not. But if give a 55 year-old pre-diabetic overweight person pancrogen, they're probably going notice marked improvement in their blood sugar. and eventually downstream effects like digestion and hopefully weight loss if they're changing their lifestyle. So I thought that was pretty cool to bring up. When we look up the cell study, pancreagen basically had gene activation within the cells. It also induced cell differentiation. There was a functional improvement to restore function to the organ. That also helped with tissue regeneration of damaged tissue. Basically they concluded that transcription factors that regulate differentiation of pancreatic cells are a pharmacological target for pancogen.

19:51 Through this action, pancreas induces multidirectional differentiation of pancreatic cells, which basically just means it works really good. Also, another 2010 study evaluated its effect on apoptosis markers, and they found that increased MCL1 and reduced P53 in pancretic treated cells support an anti-apoptotic role, so it may reduce pathological cell death in the pancrias associated with both natural aging and diabetes. Also, like we talked about the melatonin interaction, so pancreatogens metabolic effects intersect with melotonin.

20:22 So in diabetic rodent models, melotonin improves metabolic dysfunction and insulin deficits alter melatonic rhythms. Normalizing insulin could improve circadian metabolic patterns. And then also too, what's really cool about these bioregulators because of the nature of how they work chemically, they just degrade into amino acids, which really means that you can almost take any dose and there's gonna be no toxic side effects or anything like that. whereas most medication doesn't break down that way. Also too, there was a 2011 study looking at elderly patients.

20:53 So they had 33 elderly with type 2 diabetes, average ages in the 70s, and 30 healthy age-matched individuals for baseline comparisons. The diabetic patients were divided into two groups. One group received pancreagen, the other received standard diabetic care, which is probably a joke in most places. And they looked at fasting blood glucose, oral glucose tolerance tests, plasma insulin and the insulin resistance index. So what they found, glucose significant decrease, so significant increase in fasting glucose levels and improved response to the oral glucose tests,

21:25 lower plasma insulin concentrations indicating improved insulin sensitivity, a reduced insulin resistance index after pancreatine therapy, and diabetic patients had about a 70% lower nocturnal melatonin production compared to healthy individuals. They did not look at change in melatonin production, but there were noted market improvements in the sleep quality of the patients. So there's been no RCTs on chronic pancreatitis, but doctors at the Russian Institute of Bioregulation and Gerontology reported improved outcomes when

21:59 adding pancreagen to standard therapy. Patients showed better weight maintenance and nutrient absorption, fewer complaints of dyspepsia and improved fecal enzyme content over time. And patients with chronic Pancreatitis significantly improved protein metabolism when on pancrogen. And again, as far as safety on toxicity, all of these studies we talked about today, there were no reports of any damage whatsoever. And, again I don't always say that with peptides. You guys know I'm pretty reserved or pretty conservative when I talk about peptide of like, hey, this is something that you should be aware of. Again, when we look at these bioregulators, it's pretty much for what we know right now, almost nothing that is going to be a negative to it.

22:37 It's only going benefit you. So, obviously we have to talk about absorption. If given orally, a fraction of the dose reaches circulation intact, so that's why sub-Q injections, you could do intramuscular if you wanted to or better, but it's broken down into proteolytic enzymes, into smaller fragments and eventually amino acids, and they can be reused in normal metabolic pathways, which is why no toxic metabolite is produced. And being water soluble, soluable, pancreagen distributes an extracellular fluid and it has a tropism for pancreatic tissue.

23:07 So some researchers theorize short peptides might have direct homing abilities to their origin, organ of origin. Excuse me. And then any intact pancogen or large fragment might be excreted in the urine and renal clearance would likely be quite fast. Again, in worst case, you're just going to pee out any excess that's left in there. Those are the studies. If you want to look those up, And again, most of these are not gonna be published in Western medical journals. So here's my dosing protocol. And I know a lot of you probably skipped to this. What you can do, Most pancreas comes in a 20 milligram vial.

23:40 But I would do is add two milliliters of water to that. Now every 10 units equals one milligram. I recommend taking two milligrams per day for 30, 60 days, depending on the level or severity of the pancreatic inflammation or insufficiency that you may have. If you're really diabetic, you probably want to do 60 days. If You're just looking for anti-aging benefits, probably go for 30 days and then again, depending on how good or not good you are in terms of your health, that you can repeat this course two to three times per year for ongoing rejuvenation. So there's a lot of really, really cool things with pancreagen.

24:12 And I think when we look at certain things that we can do, obviously when, we improve every organ in the body, there is going to be a downstream effect. But what's really about pancogen is so much in body. When we looking at aging and longevity and stemming the tide of aging can be related to the insulin dynamics within the, body and when fix or address the root cause of where those insulin dynamic may go awry, pancragen stands out to me as one that could be really beneficial to use at least a couple times a year. So that's it for the slides. And that is pretty much everything you need to know about pancreagen in order to get started and potentially use this together.

24:47 I did want to comment just before the end of the video, someone probably will be thinking after watching this, well, can I use these instead of a GLP-1? I would say use them together, and at the very least, I think it would allow you to lower doses of GLPs and make them go a lot further. And again, the GOP-1 is doing a lot of amazing things. Obviously, if you follow me, you probably know that I'm one of the larger proponents of them on the planet. However, what we don't see in the GLP1s that we see am Pancrogen is the, again reversal of DNA transcription inside the cell,

25:17 inside of pancreas, which is leading to a more youthful state which downstream is going to affect a lots of these things, so I think everyone should be using these with a GOp-2. I plan to at least a couple of times a year run a cycle of this just to help. And again, I'm not someone with diabetes or even close to diabetes, but I do know based on the data that is something that could be beneficial for all of us. Again, when we look at that inflammation cycle, what can we do to get out in front of that as much as we can? Well, help with pancreas function because of the insulin dynamics within the body. So that's it for this one.

25:48 I look forward to your feedback. If you've used pancogen, and had a good experience, drop it in the comments below. That's very helpful for other people to see, to say that this is worthwhile and something that should be paid more attention to in world of bioregulars and peptides. So again, thank you guys so much from the bottom of my heart. Thank you, Thank You,Thank you to everyone that likes, comments, subscribes, signs for the email list, buys the products. Everyone is a part of this movement. So if you're listening to this or watching this, you are part have a very select group of people on the planet right now that are taking charge of your own health.

26:18 And it's my mission to help change the world by bringing more and more information of us out there and you guys play a of that. Thank you. My heart goes out with extreme gratitude to each and every one of you and that is it for this one. See you in the next one, peace.