Peptide Stack for Lung Health and COPD Recovery

0:09 Hey everybody, this is Hunter Williams. I hope you're doing amazing wherever you might be in the world today. Have a pretty cool video today, and this one is going to be a peptide stack for lung health. Now, as always, when it comes to some of these stack videos, there are likely many more agents out there, many, more pharmaceuticals, any more supplements and everything that you could add on to this, but for the intent and purposes of condensing this down into but I would call the most essential items that would actually help for lung health.

0:41 These would be the go-to ones that I have. So I'm going to walk through all those agents. I want to talk through why we're going use them. We're gonna walk though the dosing and then how long we gonna use. This was actually inspired by an experience that my father-in-law had earlier this year. It was probably about nine or 10 months ago now. And he was hospitalized with what I guess we would called COPD. It's kind of one of those things when you go to the doctor, he had some issues with his lungs. He had fluid in his lung. So he wasn't able to breathe very well.

1:12 I can't remember if he was on oxygen or what happened, but he in the hospital for about a week and it was pretty bad. But he ended up being okay, came home and I got him on these peptides that I'm going to talk about today. And it actually massively healed him in record time for what I guess they would diagnose as COPD. But I had talked about it a little bit. I hadn't talked all these peptides, but I talked one or two that he had used in the process once he got home from the hospital. And I have a ton of people reach out to me and say, hey, could you keep us updated on your father-in-law?

1:44 I would love to hear about what peptide you would use to heal the lungs. So that's what I decided to do in this video today is put together all those peptides that I used in the case of him. But then also too, if you are experiencing something similar with a lung health issue, I think when we talk about lung, health issues, obviously we have things like COPD, things, like bronchitis, long haul COVID or some of these other weird issues that people have. there can be different things that cause issues in the lungs.

2:16 Obviously we have smokers' lungs, emphysema, right? But I would say this stack of peptides kind of is all-encompassing and that it addresses a lot of the root cause of issue in lungs which stems back to inflammation and stems to ultimately some of issues related to metabolic health. So that's what we're going to get into today. I'm excited for this one. Hopefully you are as excited to listen to it as I was in researching and making and compiling it together. So strap up. And as always, before I jump in, just remember to make sure you're on the email list.

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3:18 platforms that will be told in the future, but the email list is the place to be. So check that out. Make sure you're on it. And let's jump into the slides for today on the video on lung health. All right. Today's video is going to the peptide stack for lung. Health. We're going do a deep dive into regenerative respiratory therapy. Say that 10 times fast. Let's get into it and talk about this. I'm not gonna go super deep, but I am gonna back up a lot of this with some clinical evidence, because I wanted to make sure the things that I've talked about, we at least have, if not human data, some sort of animal data or testing that we can say like, hey, there is direct evidence because there's a lotta peptides

3:54 that could indirectly help with the lungs. But when we talk about lung health, I wanna condense these down into ones that know for the purpose of an acute or a chronic issue with a lung is gonna help. Now, just to give you a frame of this, and I'm always kind of blown away by some of these health topics that I talk about that. I don't really think about it that much. And then maybe you're affected by it in your own life like I was with my father-in-law and you realize, wow, there's so many more people dealing with this. So when we look at lung issues, chronic respiratory diseases were the third leading cause of death globally.

4:28 in 2019, responsible for approximately 4 million deaths in 454 million cases. And again, that's pre-COVID. I wasn't able to find any updated numbers just from doing a cursory, quick internet search. In standard treatments, managed symptoms would often fail to reverse underlying lung damage or halt disease progression of the lungs. This has sparked interest in regenerative and modulatory therapies, a la peptides, including peptide to support lung tissue repair and reduce chronic inflammation. We also Again, I just can't stress, man, think about that 4 million deaths in 2019 and 454 million global cases of people with lung health issues.

5:06 So this is obviously not small potatoes when we look at it. Just to give you an overview of the stack, the first one's going to be bronchogen. We have another peptide called Conlutin, you may not have heard of. Another one called VIP, vasoactive intestinal peptides. we have TB 500 and then GHKCU. And I'm going talk specifically about some of those ones that you've probably heard and don't typically associate with lung health, what they're actually doing. But let's look at bronchogen first. This is going to be a very lung-specific peptide. So broncogen is a bioregulator peptides, and it's a synthetic tetrapeptide derived from broncho tissue.

5:42 It acts as a gene expression modulator, giving lung tissues a molecular repair signal to restore normal function. Basically, the way these bioregulator peptides work, especially the injectable ones, which I feel are much more efficacious than the oral ones. The oral one's are still good to use, but when we look at the Injectable one, what is going on is that they bind to DNA and histone proteins inside of lung tissue, Which then modulates gene transcription in the lung cells.

6:13 This then upregulates developmental transcription factors that drive tissue repair and cell proliferation. What is interesting about bioregulator peptides is that they are organ specific. And so whereas a peptide like TP500 is going to be a little bit more systemic, bronchogen is actually going work at a DNA level to help repair lung tissue. So when we're injecting broncogen, What is actually doing, if you think about this in more of a story or metaphor format, more injecting this peptide, the peptides now travels into the lung tissue and into lung cells, goes into nucleus of those cells and is rewriting the DNA.

6:52 So it's actually upgrading the code inside of lung tissues to express a more youthful state. And that's what's so interesting about peptids and especially some of these bioregulated peptidies is that they're tissue specific, so they are going to work specifically on a tissue instead of systemically, even though systemic can be good in a lot of cases. However, for someone that's dealing with an acute chronic issue like lung health, like my father-in-law was, we can take this peptide and pretty fast see results to where that DNA is now rewritten to reflect a less inflamed, more youthful state, which is pretty cool.

7:27 I mean, if you think about that, it's an amino acid sequence that is working on DNA to be able to go do that. It's pretty amazing what it does. Now let's look at specifically what are gonna be some of the key benefits. One, we're going to have bronchogen restoring lung structure. It repairs bronchodilium epithelium in COPD models. And also boosts surfactant protein B production and increases secretory immunoglobulin A for improved immune defense.

7:57 Basically helping restore the structure of the lung cells, but then also helping with immune upregulation in the lungs. It's also going to have anti-inflammatory effects. It significantly reduces chronic airway inflammation. Also lowers TNF-alpha and interleukin-6 levels, normalizing the immune environment inside the lungs. And again, those are inflammatory factors that when our lung tissue is damaged or we have COPD or emphysema or something that are upregulated that cause inflammation or that a reflection of inflammation and bronchitis will help bring those down.

8:28 It also has been shown to have anti-aging or gero protective potential. So it may have age reversing effects on the lung function and reduces fibrotic changes and promotes tissue repair over scarring. There also are animal studies to show bronchus should improve multiple biomarkers of lung health, cutting neutrophil infiltration and pro-inflammatory cytokines while restoring broncho architecture. Again, it's repairing the architecture and structure of the lungs, but also bringing down some of these inflammatory markers, which again then ends up resulting in a more youthful state of lungs which is why it would be considered kind of an anti-aging peptide specifically for

9:05 the lung. Now, let's move to condolutin. Condolutine is another bioregulated peptide. So in terms of mechanism, it works very similar to bronchogen. It's a little bit different though. it's different amino acid sequence. Its a lung specific peptid bi oregulator that targets bronchiomycosa. In normalizes gene expression in airways through epigenetic regulation, much like broncogen does. But where it is different is that it triggers stat one phosphoration while inhibiting stat three activation, which in simple terms just creates a signaling

9:39 bias that promotes resolution of inflammation specifically in the bronchial mucosa. Again, it works through epigenetic regulation. So doing the same thing that broncogen does at a DNA level also helps to modulate the immune system. It regulates inflammation and oxidative stress defenses. And again, why it's different than broncosin and why we'd want to pair it in this stack is that it promotes anti-inflammatory pathways while also blocking pro-inflammatory signals in the body. And then when we look at some of the data around it, again, when dramatically blunts the release of TNF-alpha-interleukin-6 and also interleucin 17 in

10:19 lipopolysaccharide-activated immune cells. It also helps dampen excessive immune response that damages lung tissue. it also modulates immune cell adhesion, it reduces white blood cell adhesive to activated endothelium in the lungs, which limits the recruitment of inflammatory cells into lung tissues during inflammation. And again, when we compare it with bronchogen, a little bit more on the immune side of things that maybe broncogen is doing. And then we also have antioxidant gene effects. It up regulates antioxidants defenses while suppressing inflammatory enzymes like COX2. it also protects lung cells from oxidative stress and may slow fibrosis as well.

10:54 in vitro tumor necrosis factor production or excuse me, the bronchodivirhive tripeptide inhibited in-vitro necrosis factor TNF production in LPS activated monocytes, which is another way to say it's bringing down inflammation. inside of lung cells. And then a 2022 study in the International Journal of Molecular Sciences found clear immunomodulatory actions with conlutin influencing the STAT1 and 3 signaling to reduce inflammatory outputs. Again, think of this as more of a specific bioregulator peptide that is working on the lungs, but more specifically immune health in Thymus Alpha-1 that

11:32 is great for our general immune system of the body. This one is going to be more specifically targeted to the immune systems going on in the lungs. Now, when we look at clinical data for lung health, if there was one peptide that has the most clinical data is definitely going to be VIP. So it stands for vasoactive intestinal peptide. It's a naturally occurring 28 amino acid neuropeptide, meaning that we have it in our bodies endogenously. And it works through these pathways. One, it worked through bronchodilation. it relaxes the airway and smooth muscle, widening breathing passages.

12:03 especially in the context of someone like my father-in-law that had imperative pathways of breathing. This was great. It also works on basodilation, dilates pulmonary blood vessels, which improves oxygenation, so it's going to help get more oxygen to lung tissue. And it also, as well, works as an immunomodulatory peptide. it calms inflammation and promotes regulatory T cells. VIP acts with a BPAC1 and BP AC2 receptors on airway smooth muscle, immune cells and pulmonary blood vessels serving as a brake on immune activation.

12:37 And again, it's going to help calm some of the inflammation that is going on with the lungs. When we look at clinical trials, there was a phase two trial with 20 patients showed that VIP was safe and well tolerated. What they noticed that it was market reduction in TNF alpha production, increases in regulatory T cells and lung fluid, and dampened exaggerated immune responses, which in a lot of cases when we look at something like long COVID, is very related to this over activation of the immune system, which then causes all of these downstream issues.

13:08 When we look at VIP, there's evidence to suggest it helps with asthma, it improves airway function without significant side effects. It also works to improve exercise capacity and gas exchange. And then also we see it in COVID-19 with emergency use for lung protection, cytokine storm. Obviously that was probably something back then if you mentioned VIP on the airwaves, you are getting shut down. But VIP also during that time has emerged as a promising drug candidate for the treatment of cardiopulmonary disorders such as PAH,

13:38 asthma, and COPD. And again, just from my own experience with my father-in-law, it worked amazing for him. Then we have TB 500 and TB-500 you probably think of, oh, my shoulder hurts or my joints hurt or by knee hurts, or something like that hurts. I'm going to use TB500. That is true. However, there is a lot of data around TB five hundred actually helping with lung tissue. When we talk about TV 500, it is a synthetic version and a fragment of thymus and beta four, which is an endogenous peptide to the human body.

14:14 And thimus beta-4 is 43 amino acid protein found in platelets, wound fluid and lung tissue, and it orchestrates healing through multiple mechanisms. One, we have cell migration. TB 500 binds to actin, which helps epithelial cells cover damaged airway surfaces. It also helps with angiogenesis. So it promotes new blood vessel formation and damage lung tissue. Also is anti-inflammatory. Reduces cytokine production and modulates NF kappa B signaling. And then it's also anti-fibrotic as well.

14:44 It inhibits TGF beta-driven myofibroblast activation, which prevents scarring of the lungs. And again, when we look at this, obviously TB 500, T-timus and beta 4 is a peptide that works systemically in the body, but specifically is going to help if lung tissue is injured with those things like stem cell migration, angiogenesis, and helping bring down inflammation. When we look at lung health issues, TB 500 really shines when it comes to fibrosis. In a bleomycin induced IPF mouse model TB 4, or thymus and beta 4 halted inflammatory processes and led to substantial reduction in lung scarring.

15:23 Also treated lung showed a fewer inflammatory cells and less collagen deposition. We also had enhanced regeneration, which is pretty cool. It stimulates alveolar epithelial cells to proliferate and migrate, Which then encourages endothelium cells, to form capillary tubes which improves blood supply to the lungs. Also stabilizes HIF1 alpha to promote cellular cleanup and survival. And then we also have acute injury benefits to injuries of the lung. Mice with LPS induced acute lung injury had better outcomes with thymus and beta 4 They had improved oxygenation, less edema,

16:00 which in a lot of cases, especially with my father-in-law, there was a ton of fluid on his lungs and swelling and enhanced endothelial barrier function and a potential for ARDS and severe pneumonia in lot cases. And then from a journal in 2012, Annals of the New York Academy of Sciences, thymus and beta-4 treatment led to halting of inflammatory process and substantial reduction of histological evidence of lung injury. Again, when we look at fibrosis and we looked at some of the swelling and edema issues with the lungs, TB 500 shines with that.

16:33 We also have GHKCU. And again, so we just talked about how TB 500 probably didn't think of it being a first line defense for the lungs, GH KCU is as well. GH kcu again the copper peptide is a tripeptide naturally occurring in human plasma that declines with age. Obviously we have ghkcu levels fall off probably by around 80% by the age of 60 from where they were in their twenties. It's discovered in the seventies it affects expression of over 4,000 genes tilting them towards regeneration.

17:04 And when we look at mechanisms, it's going to activate antioxidant pathways, up-regulates NRF2, increases glutathione and neutralizing reactive oxygen species. It also reduces inflammation, down- regulates NFKB, and lowers inflammatory cytokines while also boosting antioxidate capacity. and it stimulates repair. It increases collagen and elastin synthesis and promotes angiogenesis via VEGF upregulation. But now let's look specifically around lungs and fibrosis data.

17:34 I thought this was pretty cool and when I was doing an update video to GHKCU a couple months ago, I came across this and I just didn't know the evidence we have around lung health. There was this one model in cigarette smoke exposed mice that GHK, so you attenuated emphysema development, preserved alveolar structures, reduced interleukin 1 beta and TNF alpha levels by significant margins. It also has anti-fibrotic action on lung tissue. In bleomycin fibrosis models, GHk showed strong anti fibrotics effects.

18:06 There is less collagen deposition, better lung compliance and suppressed TGF beta SMAD signaling. And then we had a gene expression reset. And this is where it is also really powerful, much like those bioregulators is going to work at a DNA level to signal more youthful genes. Componational analysis found GHK reversed gene expressions signature of emphysematous lungs, shifting from destruction to repair programs. Basically what that means is if you take someone that has smoked for a lifetime, they have emphazema of the lungs. GHK is going to go into that tissue, see that the DNA is expressing towards inflammation, towards a very disease-like state,

18:43 and start to reverse some of that, which ends up repairing and regenerating a lot of lung tissue. Also, 2022 Frontier and Molecular Biosciences studies showed GH KCU restored glutathione levels, boosted total antioxidant capacity, normalized MMP9 and TIMP1 imbalance, that led to tissue breakdown in emphysema. And again, so it's working on all these pathways to bring down inflammation in Emphyzema models, which for someone that is dealing with that, is pretty powerful. Now, when we look at the protocol, this is the dosing.

19:16 We're going to have bronchogen. What I like is two milligrams per day for 12 weeks, and you would just do that every day. I'd like Conlutin to the same dose, two kilograms per, day every, for twelve weeks. VIP, you can do VIP as a nasal spray or an injection. And I like 50 to 100 micrograms. In the case of a lung issue, I would say use at least 100 mcg. Again, it can be as nasal or injection for 12 weeks for every day. TB 500, 2mg everyday for twelve weeks. GHKCU, also 2 mg injection everyday.

19:46 We have, and just to sum that up, we have bronchogen and conlutin, which provide a complementary lung-specific regenerative signals. We've got VIP that reduces inflammation and a broncho spasm. You have TB 500 that accelerates repair and prevents scarring in the lungs. And then we've have GHKCU that orchestrates broad regenerate and protective responses in lungs And again, this is all for 12 weeks. I would say see where you are 12-weeks into this. If you needed to continue to heal after that, there's no reason that I wouldn't say that you couldn't do these for longer than 12 week,

20:17 especially if it is an acute issue. For instance, in the case of my father-in-law, I mean, he was hospitalized for seven days. It was pretty bad. We were kind of scared for him, but when he got home, We did these and within 12 weeks, he was pretty much healed all the way. And so I'm not saying that's gonna be the case for you, but a lot of times three months of these peptides, you're gonna notice a pretty dramatic change. Then when we look at, just to sum up again, we have a multimodal healing strategy. Again, when I make these stacks, I really focus on attacking these things from different pathways. So we structural regeneration of the lungs with the bioregulators.

20:48 We're going to have inflammation control through the VIP, through TB 500 and GHK. we're have immune modulation through conlutin, We're going to have fibrosis prevention from the TB 500 and GHK. And then we're gonna have the gene expression reset, which comes from, the bronchogen, conlutin, and the GH K as well. And again, just to remind you, this is all experimental. This is just me. I'm a guy talking on the internet that has seen these things. And, again I am just presenting evidence. That this not a guarantee that it's going to fix all the tissue or issues in your lungs when it comes to that.

21:19 But I have seen good evidence anecdotally and clinically when we look at some of the literature around these thing to show that these in the course of 12 weeks likely will have dramatic benefit to the lungs. And that is the peptide stack for lung health. So nothing too complicated, pretty simple. When we look at these things, I would say in most cases, it's pretty affordable as well. And again, just in my own personal experience, in the direction of someone that had pretty severe issues with their lungs.

21:54 And again, I've heard anecdotal reports and feedback from other people that have sent me messages, the same thing. Again, it was not one of those things that I realized was as big of a problem as it is. But when you look at it again third leading cause of death, Lung health issues when it's compared to some of these other larger issues that we probably give more attention to like cardiovascular disease like cancer, lung health is a big deal in millions, hundreds of millions of people suffer from lung, health, issues around the world. every year and again, if we could get more people exposed to these peptides, I think it would do them well.

22:28 And hey, the cool thing about all these peptides relative to some pharmaceutical drugs is you obviously have to use peptide responsibly. But when we talk about these Peptides these are all peptids that as it stands today as someone that doesn't suffer from any issues with my lung health that I could use for me just to increase performance, just To improve my aging parameters and blood work. And so there's very little downside to using these, even if you're already a healthy person. Now in the context of someone with acute or chronic injury to the lungs, obviously these are going to be massively beneficial.

23:02 But what I love about these peptides specifically is that there really is very low downside. Obviously you have to beat smart. know what you're doing. And I advise you to take that responsibility upon yourself and take matters into your own hands and make sure you are doing the responsible thing when it comes to peptide use. In closing, thank you guys so much. I am so, so grateful as this time of the filming of this video will probably come out next week, but it is going to be Thanksgiving. And just my heart overflows with gratitude when I look back on the journey that I've had in this world to being able to bring this information to you guys.

23:38 The feedback that get from people really makes this a dream come true to get to bringing these things to. So thank you guys so much. Without you, guys, I don't exist. So whether you like, you comment, subscribe, use my code places, that goes so further than you probably realize when it comes to supporting me to allow me bring these messages to you. And at the end of the day, the best peptide and hormone and biohacking information into the world. Thanks to your guys I have the opportunity to get to work on that. My heart goes out to all of you and I will talk to the next one.

24:10 Peace.