Vesilute: A Bioregulator Peptide for Bladder Health
Today I want to talk about a Russian bioregulator peptide called Vesilute. It pairs really well with Prostamax for men, but it also works for women dealing with overactive bladder. This one won't change your life unless bladder issues are part of your daily reality. If they are, this is worth your attention.
What Vesilute Actually Is
Vesilute is a synthetic dipeptide, meaning it's two amino acids long. It was developed at the St. Petersburg Institute of Bioregulation and Gerontology. It's made up of L-glutamic acid and L-aspartic acid, and it targets the urinary bladder system specifically.
There's also an oral version called Chitomyr, but I'm focused on the injectable here.
If you've followed my content on bioregulators, you know these peptides are tissue-specific. They target individual organ systems and work to bring them back toward a more youthful state. Long-term peptide studies in rodents have shown 20 to 40% lifespan increases with reduced tumor incidence, so there's a longevity angle too.
How It Works
The peptide enters bladder cells through peptide transporters and reaches the nucleus. From there, it works on gene regulation.
Think of it as an epigenetic switch. It upregulates genes for tissue repair, proliferation, and metabolism in bladder cells. It promotes regeneration of the bladder lining, improves bladder wall function, and normalizes the detrusor muscle tone.
It's also anti-inflammatory. It reduces chronic inflammation by downregulating inflammatory cytokines in bladder tissue.
The Benefits
Improved bladder control. Reduced urgency and frequency. Fewer sudden urge episodes and accidents, which matters a lot for women with overactive bladder.
Chronic cystitis relief. The anti-inflammatory effects strengthen the bladder lining and may break the cycle of recurrent UTIs. This isn't an antibiotic, but I think it could work as an adjunct for people who suffer from frequent UTIs. That's just my opinion, nothing medical.
BPH support. It improves bladder elasticity and detrusor function in men with benign prostatic hyperplasia, which enhances urinary flow.
There's also a quality of life piece. Women with overactive bladder reported their worry and discomfort dropped at a rate 1.5 times greater than actual symptom frequency. That means better sleep, less bathroom anxiety when traveling, less social embarrassment.
The Russian Data
A 2013 BPH trial, double-blind placebo controlled, showed men had a 42.7% improvement in maximum urine flow rate. IPSS scores, which measure bladder dysfunction, dropped 24%. Benefits were sustained one month post-treatment.
A 2013 women's overactive bladder trial used 50 women age 48 to 80. They saw significant reduction in daytime and nighttime urinary frequency and incontinence. No side effects versus standard therapy.
A combination therapy study used 100 men with BPH and overactive bladder. Vesilute plus an alpha blocker far outperformed the alpha blocker alone. Only minor injection site reactions were noted.
When you stack the percentage improvements versus placebo, you see 5.2% flow rate improvement in control versus 42.7% with the peptide. Quality of life was 27% improvement versus 3% in control.
Safety
Excellent tolerability. No serious adverse effects in any clinical trial. Not allergenic. No drug interactions.
That's the cool thing about bioregulators. Worst case, they don't do anything. They're amino acids, so your body breaks them down like any other amino acid and excretes them. Compare that to the typical pharmaceutical options for overactive bladder, which come with a host of side effects.
How I Dose It
I like 1 to 2 mg daily subcutaneously for 60 days. Some of the Russian trials used 5 mg intramuscularly three times per week. If you want to do that, knock yourself out. I prefer the longer, lower-dose approach.
Two to three courses per year. If you really struggle with this, three courses is fine.
For men, pair it with Prostamax at the same dose. That's the bladder-prostate strategy for comprehensive urinary management. Track your three-day voiding patterns, how often you're getting up at night, and how your flow is doing.
You typically get a 20 mg bottle. At 1 mg per day for 60 days, you need three bottles per cycle.
What to Expect
Days 1 to 7, subtle improvements. Some people notice reduced nighttime urination within the first week. Some people actually pee more in that first week because the flow is normalizing and improving. That's normal.
Weeks 2 to 4, clearer benefits. Reduced urgency, fewer bathroom trips, stronger urine stream.
Post-course, benefits typically last 3 to 4 months. The older you are or the worse your BPH, the more often you may need to run it.
The sleep piece is what I keep coming back to. If this takes someone from three nighttime bathroom visits down to one, that's huge. Sleep affects everything. Mood, metabolism, energy. That alone is worth the cost of admission.
What I Want to See Next
I'd love to see how this affects actual prostate volume in men, especially paired with Prostamax. You'd need an MRI to measure that. Subjectively you might see fewer bathroom trips, and objectively your PSA might drop, but I want to know if the prostate itself is getting smaller or at least not growing.
That's something I'd like to try myself at some point with a whole-body MRI to track changes over time.
My Take
There isn't a ton of human or rodent data on Vesilute. The Russian trials show efficacy, and anecdotally I've seen good results in people I coach. Compared to over-the-counter supplements for bladder issues, this is about as good as it gets outside the research world.
I personally don't deal with bladder issues yet, but almost every man will at some point. If I can run a couple of cycles a year for the rest of my life and avoid that, I'll take it.
If you've used Vesilute, drop your experience in the comments on Spotify so other people can learn from it. I can't promise it works for everyone, but relative to the cost and what it can do long-term, I think it's worth trying.
Full transcript click any paragraph to jump video
Hey everybody. This is Hunter Williams. I hope you're doing amazing wherever you might be in the world. Today's video slash podcast is going to be all about a peptide known as Vezelute. So this is actually one of the Russian bioregular peptides for the intents and purposes of this video. There is an oral version of this. The Russian name, I believe, is called Chitomyr, C-H-I-T-O-U-M-R. I don't believe that's how it's spelled, but today I'm going to be talking about the injectable version Now I've done a video pretty recently on Prostomax,
and that is the injectable bioregular peptide for the prostate. Obviously, if you're using that, you are probably a man because only men have prostates. However, Vezolute pairs really nicely with Prostermax, so I'll talk about that today. What's cool about Vesolut is that if your a woman and you suffer from overactive bladder, which is not uncommon as women get into perimenopause and postmenopausal, it's a peptid that you could use as well. So Vazolote would be a little bit more applicable for men and women, whereas Prostomax really is going to be a peptide for man. However, I think that people that don't get the results they want with ProstaMax could enhance those results with Vezolute.
And actually for the purpose of frequent urination or BPH or overactive bladder, whether that's a man or a woman, i would absolutely recommend that you pair ProstoMax with the Vesolut. Obviously, if you're a women you would just use Vazolote. But there's some pretty compelling evidence from Russian literature that I was able to dig into, thankfully now with AI that's assisted, that can translate some of that literature, it's been siloed for years. So that is what we're going to talk about today. I think it is pretty cool. And again, this isn't going be a peptide that groundbreaking or life-changing, unless you're someone that does suffer from overactive bladder,
or have had issues in the past with BPH or just frequent urinations getting up in And I think if you use this two to three times a year, you're going to see some sort of result. I can't promise it's going fix everything, but as you can see in some of the data that we're talking about today, there's pretty compelling evidence that
it does work. That's what we'll be talking. But as always, before I jump into the slides, thank you guys so much. Make sure you run the email list. Check that out. You can check out the peptide cheat sheet. I do have the dosing for Vesalut. If you want to print that out from the Peptide Cheat Sheet, you can that. And also too, I have my own private group up now, it's called the Axion Collective. It's 99 bucks a month. You cancel it anytime. We do a good amount of people in there rocking and rolling right now. So it is really cool. You can private message me, you can talk with other people in the forum and we do live calls every Thursday night at eight o'clock Eastern time.
So you hop on those calls, ask me and Taylor questions if you want to, but it's a really good community. It's not all about me. There's lot of really learning stuff in there. And then obviously too you have access to me if. You so desire. But that's it. Let's hop into the slides and today we're going to learn about Vesalut. All right, let's get into it today. We're gonna be talking about Vezolute, which is a peptide bioregulator. And we're going to talk about it through bladder health. If you're familiar with the bi oregulators, basically they're peptides that are tissue specific, meaning that they really, even though they can have some downstream effects, they've really focused on specific organ systems in the body to optimize them.
To just give you a little bit of background, Vesolut is synthetic dipeptide, Which means it's two amino acids long. It was developed at the St. Petersburg Institute of Bioregelation and Gerontology. It's comprised of L-glutamic acid and L aspartic acid, and specifically targets the urinary bladder system. It addresses age-related bladder decline through tissue-specific peptides and Long-term peptide studies show 20 to 40% lifespan increases in rodents with
reduced tumor incidence. Again, that's where it's a bladder peptid, but especially in combination with some of these other bioregulator peptides, it is doing really cool things for longevity. And I think we are just starting to scratch the surface. Maybe we'll look back at content like this that myself and other great content creators are putting out and think like in 50 years, hopefully this becomes much more mainstream. Let's look at how it works. It's very similar to a lot of the other bioregulators. If you've listened to my content on those, basically the peptide enters bladder cells via peptides transporters, which reaches,
reaches inner cellular targets, including the nuclei. And then it worked on gene regulation. What's really cool about these bi-regular peptids is they're going to specific organs, the body inserting themselves into the nucleus of cells inside that organ and then kind of For lack of a better way to say it, rewriting the genetic code in there to reflect the more youthful state. It acts as an epigenetic switch, upbringing the genes for tissue repair, proliferation, and metabolism in the bladder cells specifically. In doing so, it promotes urothelial regeneration, which is just the tissue in your bladder, improves bladder wall trophism,
normalizes detrusor muscle tone, All that to say is it helps improve bladder function. And so whether you have a weak flow, whether have an overactive bladder, it's helping normalize that tissue, which as we age gets exposed to oxidative stress. It gets to expose to all these things in our world that causes them to not function Ideally, also it's an anti-inflammatory. It reduces chronic inflammation by normalizing immune responses and down-regulating inflammatory cytokines specifically again in that bladder tissue. Now, when we look at that, it results in these benefits.
One, we have improved bladder control. We have reduced urgency to use the bathroom, reduced frequency. And then I think most importantly for people who'd be using this incontinence, I know as a male, that's going to be one of the things that most males struggle with as they and then patients report significantly fewer sudden urge episodes and accidents. I think that would be more applicable to the female side of things here. We have chronic cystitis relief. So the anti-inflammatory effects strengthen the bladder lining, breaking the cycle of irritation and recurrent urinary tract infections. Again, this is not an antibiotic, but for people that suffer from frequent UTIs, I this could be something that will be used as an adjunct for the treatment
is that, and again, that's just my opinion, nothing medical. But we also have BPH, which is benign prostate hyperplasia support. It improves bladder elasticity and detrusor function in men with benign prostatic hyperplasia, which is going to also enhance urinary flow. Now, why does this matter? Because I think for the purpose of even just being an annoyance, it's a quality of life thing. Beyond physical improvements, Vesalut delivers profound psychological benefits. Women with overactive bladder reported worry and discomfort dropped one and a half times than actual symptom frequency, which results in better sleep from
fewer nighttime trips, confidence to travel with bathroom anxiety, reduce social embarrassment from having to go to the bathroom. And then obviously if you're a man, nothing is more embarrassing than when you are in a wall or a line of urinals and you go the to bathroom and have to get really bad and then for whatever reason you can't there, Vesalut will help with that and preserve autonomy and aging. Then again in studies we see 27% quality of life improvement in BPH patients and 24% symptom reduction which is based on a score that they use to weigh
people's bladder, basically the bladder strength, the blood or frequency and everything. And we'll talk a little bit about that. There was a 2013 BPH trial. It was double blind placebo controlled, and then men showed 42.7% improvement in maximum urine flow rate. Then again, to IPSS scores, which used to score Basically bladder dysfunction dropped 24% and the benefits sustained one month post treatment. There's a 2013 women's overactive bladder trial. They used 50 women age 48 to 80. there was a significant reduction in daytime and nighttime urinary frequency and urinal incontinence.
And then no side effects detected versus standard therapy. And in combination therapy, there was 100 men with BPH and overactive bladder. They used the peptide, the Peptide Vesalute plus an alpha blocker, and that far outperformed just the alpha-blocker alone. Again, Di-PSS improved. Down 2.43 versus placebo, which is, or in this case, it was the Alpha-Blocker which was a control, 0.38. So there an improvement in those scores and only my injection site reactions were noted.
Most of the bioregulators, you might get a little sting from them, but they're really not bad and tend to not have too bad of a injection site reaction or anything like that, like you do with some other peptides. But again, just looking at some of these clinical outcomes, when we just look at flow rate, obviously see massive improvement in the flow rates. So 5.2% improvement and the control group versus 42.7% and improvement flow rating in men. Again, that IPSS score was much better, about three times better. in the peptide group versus the control group, quality of life, 27% improvement versus 3% in control, and then urinary void reduction around 3%, versus 0.17%. Again,
those are just the percentage improvements versus placebo or standard alone. When we look at the safety profile, excellent tolerability so there were no serious adverse effects in any clinical trial. It's not allergenic. There's no drug interactions. Again, what's cool about these bioregulators is the very worst case, they're not going to do anything. Their amino acids, the degree down to the body can break them just like any other amino acid, and you just end up excreting it and metabolizing it. So as opposed to normal drugs, which can have a host of side effects, I know there's tons of drugs for overactive bladder, some of which may work, The peptides do really, really well.
And again, in the worst case, you just end up getting nothing. But I've seen in most people that use this, at least some sort of improvement. And again, individual intolerance is very rare. So don't worry about any sort of reactions like you will with some of the peptides. Now when we get to dosing, I like the injectable version. Obviously there's that oral version, but I liked one to two milligrams daily subcutaneously for 60 days. Some of trials in Russia, they would do five milligrams injected intramuscularly three times per week.
If you want to do that, knock yourself out. I just prefer doing these over like a 60 day window at one, two millimeters per day. to get a little bit more broad exposure to it instead of that short-term exposure. And then I like two to three courses annually. If you're someone that really struggles with this, I think three course is totally fine. But if you are just looking forward from an anti-aging perspective and just to kind of cover your bases, Again, if you're a man, I would say pair it with Prostomax. Obviously, for a woman, you don't really need to do that because you Don't have any prostate tissue in your body. But if your man you could pair same dose one to two milligrams, injected sub cue.
And again, the reason for that is the bladder prostate access strategy for comprehensive Urinary management in men and then again track three-day voiding some of those scores how often you're going to the bathroom how Often you are getting up to go to bathroom in the middle of the night and also to your urinary continence or incontinence how well that's doing and how the flow is but again very very easy to use from a dosing standpoint. Typically you'll get a 20 milligram bottle. And so if you were going to, use that for a cycle, what would that be?
If you used, you know, for 60 days, You would need, if he used one milligram a day, he wouldn't need three bottles. If he use two milligrams a And again, same thing with Prostomax, so relatively affordable to do. What to expect? This is typically what I see with most people. Days one to seven, subtle improvement. Again, some users notice reduced nighttime urination within the first week. Some don't. I actually see people because I think it's normalizing the bladder stream and a urinary stream. some people will actually be peeing more within that first, week which I, think is normal.
i've heard of that happening and it is because they are basically improving the flow. And so a lot of times it's like coming out better and then it kind of normalizes to where they're not going to be urinating as much. Weeks two to four, you see clear benefits. So reduced urgency, fewer bathroom trips, stronger urine stream, and most users experience meaningful improvement. Then post-course, typically I see the benefits last three to 4 months after completion. Again, so if it is something you struggle with, You might just have to do this two cycles per year to get the effects and do that every year depending
on how you end up doing it. I think the effects can last longer than that, but the older you are or the more BPH, more overactive bladder is a struggle for you. You may have to run this every year. Again, for the cost for me, it's well worth it But subjective improvements, we see reduced urgency, fewer nighttime awakenings, less hesitancy and straining, improved confidence and comfort and better sleep quality. I think that's one thing when we look at the bladder, it's so important to really think about is how many times you're interrupting your sleep to go to the bathroom, which then throws off your asleep.
It doesn't allow you to get into some of those deep sleep cycles, Which then impairs every other area of your life, because how well you sleep is going to affect everything. So I think to that point, at the very least, just the fact that this may take someone from three nighttime bathroom visits to one nighttime, bathroom visit could be huge and make a massive impact on someone's sleep quality, which could affect their mood. It could effect the metabolism, effect their energy levels. And again, so I that alone is worth the cost of admission, but it's going to make such a difference even if you just did that.
I there's more benefits than just that alone that we're going to see long-term. But what I would be interested to is how well this affects prostate volume and men. And obviously if you're pairing with Prostomax, if it's actually reducing the size of the prostate, again, that's one thing you have to have an MRI to measure. So subjectively and objectively, you could go to the bathroom less. You could see your PSA go down. but I would love to see if this is actually affecting the size of the prostate. I think it potentially could be because it's improving some of these things, but we'll see with that.
That's one thing I'd love try myself in the future is to have a whole body MRI to which you measure the sides of prostate and then over time if it ends up Not necessarily shrinking the prostate, but for men, keeping the prostrate from growing. But objective changes, increased uro flow readings, reduced post-void residual, which is kind of just the drippage, enhanced bladder capacity, so you don't have to go to the bathroom as much or as frequently during the day, and then decreased incontinence. And then also improved detrusor function in the bladder.
So where do we go from here? I think this will become one thing. I hope that organ-specific bioregulators become much more common. in the future, meaning that for any of these organ systems, we can really just use a combo or even one of the peptides to address issues like nighttime urinations and overactive bladder. I think again, when we look at this, there's other ones you could use. So like Vessagin would pair really nice with this because it works on the blood flow specifically. As long as you have Prostomax and Bezalut, it's going to work really well together. But maybe even someone for me, I personally have never struggled with nighttime, urination really with any sort of bladder issues.
other than maybe nervous bladder, because sometimes when you're a dude, it's weird to pee in front of other guys and you might not be able to be right away. But I think for the most part, for me and my age, is not something that I really deal with. I know in the future, that's kind of something almost every single man goes through. It would be more rare for a man not to experience some of these things than for him to experienced them. And so for, me, I'm just kind conscious going forward is like, hey, if I can throw in these peptides a couple of times a year for one month or two, to get the benefits to like maybe where that's something I never have to deal with.
I think that would be great. And so again, I just hope that bi-regular peptides become much more ingrained in longevity. Now, think for people in the longevity world, these peptide kind of open up a new way because so many of the other popular peptidies are really popular because they're so strong signaling molecules, which is a good thing. You know, GLP-1s are so popular, because it helps people lose weight. So much and so fast, but with a bioregular peptide, you know, some of those 300 pounds, how much are they going to benefit from Prosimax and Fezolute? Maybe, maybe it helps a lot, But I think for the people that are in longevity that have, their metabolic health pretty dialed in,
Some of these are going manifest in the form of life extension of better health span of some of these things that even a healthy person that's going to suffer from BPH, just because it's kind of the nature of a beast as we age, doesn't have to experience. And that is where I'm excited to see some things go and kind fleshing out what we do in future with these. But that it it for the slides. And that is my take on Vesalut. Again, nothing super complex. There's not a ton of human data or even rodent data for that matter around Vezalot.
However, practically speaking, anecdotally speaking I've seen good results from it. Obviously we have some of those Russian human trials that show that it does have efficacy. So nothing large or I would guess I'd say like super big from a controlled trial standpoint. But I think when we look at supplements, this is about as close to anything that you can get. You know, obviously it would come from the research world, but anything you didn't get over the counter, that's going to have a really good effect. on bladder issues. And again, this is something just in the practice of doing what I do, which is working with people, coaching with, people talking with about peptides that
I've seen really good improvement in quality of life improvements in people. Now, again whether or something, that you have to do once every two years or even two or three times a year continually throughout the rest of your life, I don't know, but I think it's worth it to get the improvements and sleep. long-term because of how important that can be. And again, if I could get one thing out of this, it would just be that if it could cut nighttime urinations down from three to one, or two to, one or four to 1, for a lot of guys and even a lotta women that struggle with that, I think it is well worth it. But let me know your thoughts on this one.
I always say in closing, thank you so much to all the overwhelming support I get from people. My heart overflows with gratitude. Hopefully that comes through in my content for you guys in whatever shape or form that it is that you support me, whether it's liking, commenting, subscribing to the videos and to a podcast and leaving reviews on podcasts, platforms and sharing it with your friends. Whether it was joining the community, being on the email list, using my code of places, I can't tell you how far that support goes to help me bring you these messages and hopefully in return these message make a huge difference in your life and my goal with my content is to really not have anything behind
a paywall content wise to just put out the best content in the world for free so that you can act on it and make change in you own life And then hopefully, reciprocally, you would use my code of places or even join my private community to where you can interact with me and just get to know people. I think the benefit of having the community is to get the network with other people in the space. It's not so much that I'm gonna gatekeep any information behind that, but it's just to interact and have a place where we can get feedback on some of the things that you're doing. So I appreciate you guys so, much love each and every one of you.
If you have experience with Vezolute just for the betterment of a community, drop that in comments on Spotify and let other know if it, done you well, or if it didn't do anything for you again, I'm just not one of those things I can promise that it'll work. But I think it's worth it relative to the cost and relative To what it will benefit and do for You in the long run. So that's it for this one. Thank you guys so much. Love you, guys. And I will see you in an excellent piece.
