Tirzepatide to Retatrutide The Ultimate Transition Guide Dosing Protocols

0:10 Hey everybody, this is Hunter Williams. I hope you were doing amazing wherever you are at in the world. Today's video is going to be all about transitioning from turzapotide to retitrutide. So this definitely one of the more common questions I have been asked, I would say probably in from compounding pharmacies is kind of going the way of the dodo bird. Unfortunately. So a lot of people are going to the research world and trying to read a true tide, or they're going into the resource world in getting to his appetite because of what is going on with compound pharmancies, which I don't need to get into in this video, but That being said,

0:44 even people that are on trzapotide know red trutide is probably better because you look at the data that we have around, at least clinically speaking right now, it's way better. Obviously, anecdotally speaking, I would say red true tide is way. So what I'm going to do in this video is walk through how to go from trizaposide to red at your tide. The short answer is. You can kind of do whatever you want and you'll probably be okay. I have a methodology for which I think you should do as a best practice that you can do in transition between them. You kind really do it whatever want. And the short version of this is titrate down from wherever your dose on trisapatite is down to like two milligrams per week over a four to six weeks period,

1:21 and then introduce red trutide at two kilograms and kind go from there based on what you need. What I'm gonna do in this video is walk through why I believe that is. And when you look at the data over at True Tide versus True Zapetide, when he looked at a chemical components of both of them, I think it helps to understand why we want to do that because they are similar, but they're also different too. So that's what we're going to cover in. This video, as always, the peptide cheat sheet is down the link in the description. You can check that out and you can also check out fully optimized health, the hub to get information like this.

1:54 And we do live streams there every Tuesday night where you can come ask those questions. So without further ado, I'm going to share my screen. Okay, let's get into it. Today's video is all about transitioning from trisapatite to retitrutide. So let us see what is going on here. Just as an overview, trizapatide is a GIP plus GLP-1 agonist. Retitutide a is G.I.P. plus GLP-I plus glucagon aganist and obviously retritutite is the triple aginist, and when you look at it statistically, Trials have shown up to around 24% body weight reduction in around 48 weeks, which surpasses 22 and a half percent from,

2:30 or excuse me, terzapotide in 72 weeks which is a longer time period. So they're both multi-receptor drugs just as an overview. It's a synthetic 39 amino acid peptide that activates two hormones, one being GLP-1 and the other being GIP, which stands for glucose-dependent insulinotropic polypeptide. So by agonizing both of these receptors, it enhances insulin secretion from the pancreas. suppresses glucagon release, slows gastric emptying, and reduces appetite, all in a glucose-dependent manner, meaning it mimics the body's natural post-medial signals,

3:04 but in super physiologic, therapeutic way to help people lose weight. And I don't think a lot of people know this. I want to put this in here. Trisapatite is considered an imbalanced coagulant, so it was engineered to be relatively more potent at the GIP receptor than the GLP-1 receptor. So it has about a five times weaker affinity for GLp- 1 than semaglutide itself. When we look at trisapatite, the side effects are usually a little bit less because there's a smaller amount of GL p- agonism and a larger amount The GIP

3:42 skewing design of it allows stronger metabolic benefits while also keeping the GLP-1 activity at a level that is effective and tolerable since GLp-I is usually what is responsible for more of the bad side effects. That's why people tend to have worse side-effects from semaglutide than they do trisapatite. So let's compare that with retitrutide. Basically we took trizapatide and we added on this glucagon receptor agonism. It's triple agones, triagones. You probably heard it called. So it stimulates GLP and GIP to enhance insulin secretion, improve insulin sensitivity and blood appetite, but by additionally agonizing the glucagon receptor,

4:18 it can raise energy expenditure, which is how many calories we're burning in a day, albeit all things else equal, and promoting lipolysis. So, gluculon signaling in the liver releases stored glucose, but in a context of retitrutide, the GLP-1 and GIP effects, which drive insulin and satiety, counterbalance glucose elevations, resulting in net improved glycemia with added weight loss benefit. When we look at this glucagon receptor activation, it appears to dramatically reduce liver fat and improve metabolic health.

4:48 So in a phase two fatty liver disease subset red trutide between eight to 12 milligrams a week, a weak cut liverfat by around an 80% marker on average. So a lot of people will say that glucagon's role is not so glucocentric. It also affects lipid metabolism and energy balance. And so by including a glucogon effect, red trutide harnesses the benefits of trisapatite, but it's going to cause fat loss that much faster and weight loss beyond what trizapatide will alone, milligram for milligram.

5:22 Just to sum up, TERS equals GLP-1 plus GIP, red trutide equals GLP- 1 plus GLB plus glucagon. So they both have the GLp- one receptor, which obviously we know helps with appetite control, both at the G.I.P receptor which can also synergize with the glp1 effects, but the glucogon agonism is what makes red true tide that much better. Retrotide pound for pound is going to be a stronger drug. And that's why obviously everyone wants to get on it, right? So let's look at a dose in comparison.

5:53 When we have turzapotide, the starting dose is 2.5 milligrams for four weeks. Then the recommended protocol, I wouldn't recommend doing this, but the recommend protocol is to go to five milligrams. And after that, it may go up in 2.5 milligram increments every four weeks. So people go from 2,5 to 5, to 7, 5 to 10 to 12. 5. And then, pharmaceutically speaking, from the manufacturer, the recommended maximum dose is 15 milligrams once weekly. You obviously have to gradually titrate up to mitigate the side effects, because if you took 15 mg per week of turzapotib,

6:25 without stair stepping into that it's going to be very bad for you. That's all I'll say. by the end of titration, which usually takes around 20 weeks, patients are on the full dose. Conversely, we look at right at true time, same thing recommended. It's a weekly day injection. Obviously, you know, probably know that I recommend every other day injections or even daily injections to microdose, gives you a better response curve to it. But again, the dose was stair stepped every four weeks. So people start at one milligram and then they go to two milligrams and they got to four milligrams.

6:59 And then go eight milligrams, and go 12 milligrams So that's kind of the stairs up and then 12 milligrams right now, at least from a data standpoint, is the highest dose that we see in people. And I actually, like, I've talked to a lot of people that have done 20, 25, even 30 milligrams of TruZapTide a week. I don't really know of anyone that has been using more than like 12 mg a The most I've probably used is just to experiment on myself is three. And so we know that retitrutide milligram for milligram is going to be stronger than terzapotide and obviously accelerate the fat loss,

7:33 which again is why people want to switch to it. Now, turzapotide, on average, has around 15 to 22% of body weight on an average over 72 weeks in the SRMT-1 trials. And again, at the 15-milligram dose, patients lost about 22.5% percent of their weight, which was on the average about 52 pounds from a 231-pound baseline. However, even five milligrams of trisapatite caused around 15 percent weight reduction over that period. And this was unprecedented until retitrutide came along.

8:05 So retritrutite, when people took up to 12 milligrams weekly, it led to around 24.2 percent mean weight loss in a 48 week period, which was shorter than the 72 weeks of terzapatide. What's interesting about red at true tide is by week 48 people still had not plateaued. Whereas a lot of people were plateauing obviously early on in trisapatite curves were still turning down at the end of that study. So. people reached around a 20 to 22% plateau, meaning the amount of body loss, body mass that they lost from the start.

8:40 And that hit around the 72 week period. So around 48 weeks in people were still losing weight, even though albeit it was slowed when they took it up to the highest dose of 12 milligrams. So around 24 weeks, red trutide at 12 milligrams had already produced around 17.5% weight reduction, whereas trisapatite 15 milligram at around 28 weeks was around the mid teens. So three to 4% higher from red at true tide at the same time. Again, we're seeing it cause more fat loss and earlier on.

9:10 Now turns out I lowered a 1c by around 2.4 to 2 point 5 percentage points in 40 weeks and then read a true tide at 12 milligrams lower to HBA 1C by 2% on average by 24 weeks So doses of 8 to 12 Milligrams read at true Tide bought 80 brought 82 percent of patients to an a1c of less than 6.5 percent and I think on Average the average starting age a one C was around 8.1 percent which is pretty cool so This also came alongside major weight loss in patients.

9:42 Again, in week 36, people had already lost like 16 to 17% of their body mass. So aside from that, both drugs improve blood pressure, cholesterol, and fatty liver measures. But Reta-Trutide's glucagon activity might give it an edge, especially in the liver fat reduction category. So in patients with fatty liver retrotide led to greater than 80% relative reduction in liver fat content on average at 24 to 48 weeks with many patients liver, fat completely clearing on MRI scans. And I think that's cool.

10:13 We don't have data points that show that dramatic reduction interest appetite around liver. Fat and obviously people who are fat, people that are diabetic have non-alcoholic fatty, liver disease where their liver is trashed from them being so fat. So Retatrutide, I think from that standpoint as a longevity molecule to help people aging is far and away better than retatutide. So again, the glucagon agonism really, really brings in the effect of helping the liver out. For weight loss, all things else being equal, retratutite is obviously better. Obviously you can get good results with both of them, but Reddit True Tide is going to be better.

10:50 We obviously have more real world data now because FDA or the True Zap Tides has been an FDA approved drug for much longer. The Reddit true tide is because it has not. Now I did want to go over this before. you switch just something to, some things to expect in the transition. So if you stop TURS and start at a low red trutide dose, you actually may feel fewer side effects initially. People typically start with one milligram of red true tide per week. I think even if they start two, most people seem to have less side-effects, meaning negative side affects from the red TRU TIDE than the TRZ appetite.

11:26 Now there are people that sometimes will get a racing heart or get really tired. but sometimes that happens on trisapatite too. So funny enough, this is reported more that you may even feel hungrier or have some return of appetite when switching, not because retitrutide causes hunger, but because you've gone from a high level of medication to a lower level during titration. And even when people switch milligram for milligram, I think this still happens because the appetite suppression from trsapatide seems to be so much stronger. That's probably because milligram from milligram there's more of a GLP-1 component than there is in retritrutite.

12:00 So that GLP-1 being a bigger part of turzapotide is probably why people feel more appetite suppression, at least for the same dosing, milligram for milligram, than they do from retitrutide. So just be aware of it. And then if you have adapted to turza side effects, you're essentially re-challenging your system with retritrutidetitration. Any time you titrate up, just do it with caution. One question I had, is one drug harder to tolerate than the other? I don't think so. So no major red flag differences have emerged.

12:30 Red atrutides, GI side effects are dose dependent, just like trisapatides are. In the phase two trial, higher doses of red trutide had more nausea, but starting at one to two milligram greatly reduced those issues, and typically people adapted to those to where they're not getting nauseas. If you wonder if the glucagon agonism may cause any unique side effects, it can raise heart rate or blood sugar. So people that tend to get a racing heart on retitrutide, more so than terzapotide. It probably is because of the glucose aganism for what we know now.

13:00 Retritutide did not cause problematic hyperglycemia. the GLP-1 and GIP effects balance it out. So some people would say, well, like, will the glucagon agonism could actually cause high blood sugar? And in this case, it didn't because of the GLP- 1 and GDP. Does that mean that the Glucogon aganism by itself would cause High Blood Sugar? I don't know. I think it depends on the person. However, because the JLP and JIP people do not get hyperglycemic, which means high Blood sugar.

13:30 If we do have side effects, again, eat smaller, simpler meals and please remove so much fat out of your diet. People do so many better when they don't have high fats diet, high fat diets on red trutide or trisapatite. You can use some antihistamine sometimes to help with the nausea. If that ends up being a problem. Funny enough, I think less people experience nauseas on Red tritide than they do trusapatide, especially as you get into the higher doses. Although some people may they seem to get a little bit more of a high heart rate when they're on Reddit True Tide.

14:00 So you may have skipped to this and that's totally cool. This is my titration schedule. Week one, we've got 12 milligrams. If you're starting with trisapatite, and I just did this as an example to know a lot of people around this, like seven to 12 milligram mark. if I was titrating down to go on to Reddit true tide, week one I would go from 12 where I'm at, and then the next week I would go down to 9 milligrams, which is 75% of the dose, 25% reduction. Week 3, I am going to go to 6.75 milligrams. 56% percent of starting dose. 25 percent reduction Week 4, i'm going down 5 milligrams which 42% my starting and 25 % reduction from the previous week.

14:32 And then from 5, down 2 or 2.5 whatever you want to do. I just did 2 And that's going to be 17% of my start. And this is where I'm going switch over to Red True Tide. So week six, I am going come completely off and this where am I going start Red true tide at two milligrams. There you have it. This is how I would stair step it down. You're still going get the effect, you don't have to worry about stopping at cold turkey. Not that that would necessarily be a bad thing or appetite would just probably come roaring back.

15:04 But this going gradually titrate you down, your appetite will probably start to come back a little bit. But the reason I like doing this is because I'd like starting retitrutide at that small one to two milligram per week dose, because, I don't want to have to go higher than I need to. And for people that are on 12 milligrams of turzapotide, if they switched over immediately to 2 milligrams retritrutite, they're probably not going to notice anything, to be honest. But, If they take themselves over the course of five to six weeks and go down to a smaller dose they are going feel it a little bit more.

15:34 They'll probably still be a bit hungry. But they have a really good starting point to come into red true tide. And then if they had to, they can titrate from there. Because again, if you need to lose a lot of weight, you're probably going to have to titratate up. I'm a believer in the most effective doses, the minimum effective dose. But that's what I would do. So just for instance, If I was starting at 15, I'd go to 15 to 11 to 8 to 6 to 2 and then start at 2 milligrams for a true Tide. If I was doing 10 weeks of trisapatite, I would go to 10 to 7 to 5 to 4 to 2, and then start with two red trutide.

16:06 If i was going 7.5, i would from 7,5 to five to four to three to two. So you can kind of see the theme there is take it down week by week to where you're not stopping cold turkey, then you have a really nice baseline to come to the two milligrams of red true tide. And then I would use that for at least two weeks, see where you are. If you don't notice anything, then you can start to go up from there. But this just helps build our receptor sensitivity. And it also helps us isolate any bad side effects that we get from red atrutide to the red of trutide. Whereas if we introduce red a truetide, so say I had 15 milligrams a week of turzapotide and I introduced three milligrams of red truetide on top of that

16:40 and something went wrong, do I know if it's coming from the truzapitide or do i know If it is coming form the Red Truetides? It's hard to say. So that would be my recommendation. And that is it for the slides. And, that, is my recommendation for how to switch from turzapetide to retitrutide. So, as you can see, not super complex, but I do like the idea of titrating down to that small starting dose of retritrutite, then reintroducing it and going from there. Now, a lot of people ask me, can I mix turazapotide and retrutitite? Could I have like a four week window where I'm doing one milligrams of turizapitide, and one milligram of red trutide?

17:15 Or two milligrams, of trizapatide two, milligrams retutite. And I would say, yeah, I think that's totally fine. It would at least allow you to stair step into the red of true tide. And then maybe after you do that for two to four weeks, come off the trisapatite, see how you feel on the right of trutide, and then go from there. So you kind of have to use your own discretion when you are out in the wild, wild west of researching and research chemicals. But that would be my recommendation. The reason I say this is because I see way too many people on too high doses of Trisapatite.

17:46 And ultimately, this is a different topic from this video. There are so many other pathways for fat loss that we can tap into. They're not just the GLP or GIP or even the G-I-P and glucagon. It is very effective one, but it's not the only one. So let me know how this one was. I hope to hear good feedback on this. Let me like it or don't like, or if it was helpful to you or not. But I think this is a larger question that a lot of people are floating around in their minds right now, and they might not be making the switch to Red True Tide yet because they don t know. So hopefully if you are on the cusp of making this switch, this was a helpful enough to hear your feedback.

18:21 Again, I do read all the comments. I can't respond to all of them because I have to create and make things during the day. And it would take up more than my whole day to do so. Just know that I appreciate each and every one of you guys that likes, subscribe, comment on the channel. Support the email list, support the products that we sell and everything. So thank you, guys, so much. I really appreciate it from the bottom of my heart. And I mean that. Thank you. That is it for this one.