Bioregulators Vs Peptides How To Understand The Differences

0:09 Hey everybody, this is Hunter Williams. I hope you're doing amazing wherever you are at in the world. Today's video is going to be all about bioregulators versus peptides. So by the time this video comes out, I will have a hand in bringing what we know to me, the first bi oregulator cream available to the market. And that is basically a topical cream that helps soothe pain, discomfort and everything. It's basically like BPC 157 and TB 500. in a cream that you can use transdermally.

0:40 So at the time of recording this, we actually just launched it last week. It's called Regenivive. You can check it out at getregeniviv.com. Basically it's a bioregulator cream. Today what I wanted to do, because it looks like for now that we are going to be able to get bi oregulators finally here in the United States. And this is probably going take another year or two to really roll this out to the point where it is substantially commercially available. But I want to go ahead and do a teaching video on the difference between bi regulators and peptides. Basically, all bioregulators are peptides, but not all peptide are bi oregulator.

1:11 So bi regulators are a form of peptids. And for the most part, they're available orally or transdermally, like the regenerative cream is. Today, what I want to do is kind of walk through what bi regulators are versus peptidies, why they are different, and why just so you kind of understand. So today's going to be 100% of teaching video about understanding this. And hopefully if I have anything to say with it, because this is kind like what I'm working on behind the scenes, we can bring bioregulators into the United

1:41 States to available for people to use. What I am going do is share my screen, walk through that. But before I do, if you want to check out the peptide cheat sheet, you can sign up for that below. It will be in the email or the, excuse me, signup with your email, it will in description of every video. And then also to, uh, you can join a fully optimized health because, Uh, that is the best biohacking network in the world. Uh it's $99 a month. I think we have over 480 people in there at the time of this video. So it definitely is. The premier private bio hacking club in.

2:13 And, they actually had access to the bioregular cream first. And we pretty much sold out to them first. So they got first access to this. If you want things like that, if you're more interested in by regulators, that's kind of what we're talking about on the inside there. Without further ado, I'm going to share my screen and today we are going learn about bioregulators versus peptides. All right, today's video is going to be about bioregulators versus peptides, and we are going learn the differences and similarities, if there are any. So basically, where do we start? So bi oregulator are short-chain peptide derived from animal organs and tissues.

2:45 They act as modulators of a bunch of different physiological processes in the body by regulating gene expression at the DNA level. And the way they work is they restore the function of specific organs and tissues by normalizing protein synthesis, promoting cellular regeneration and modulating immune responses. And as far as origin goes, they are commonly derived from animal organs, for instance, the thymus, of different animals, a lot of times it's either pigs or cows, and these bioregulators can be specific to certain tissues and organs.

3:16 So think bi oregulars, we have specific bi regulators that work on specific organs in the body, like the brain, the pineal gland, thymus, prostate, ad infinitum. So how are they different from peptides? So basically peptide are short chains of amino acids linked by peptid bonds. So they can act as signaling molecules in the body influencing a range of biological processes. And basically, peptids are involved in lots of bodily functions, including hormone production, immune response, and cell signaling. They are often used therapeutically to target specific physiological functions And these are basically synthesized in a lab,

3:53 or they can be derived from natural sources, including plants and animals. So peptides think more certain outcomes, whereas bioregulators think certain organs. Bioregelators help modulate organs, peptide help create certain outcome in the body. That's my best way to summarize how they're different. Now, what I'm going to do in this video is basically explain like a compare and contrast between different structures of molecules or the structure of the molecule and how they're different and similar. So the first thing I want to talk about was the sequence length of amino acid change with bioregulators versus peptides.

4:29 Biore regulators are typically very short peptide and they often consist of just two to four amino acids change. So this being short, the brevity of their sequence is basically what makes them different from your traditional peptides. So specific bioregulators such as epitalon is a tetrapeptide, meaning it's three amino acids and thymogen, it is dipeptide. But basically they are very short chain amino acid. Now, peptides are a little bit longer.

5:00 So peptide have a much wider range of amino acid links, and they typically vary from a few amino acids up to 50 amino assets. Some therapeutic ones and different combinations can even be longer, so for instance, BPC157, one of the most common peptids is 15 amino-acids in length, thymus and beta-4, aka TB500, is 43 aminoacides. A GLP-1 peptid like semaglutide is 30 amino acides, and even insulin is 51 amino acids. So when we look at bioregulators versus peptides, one, the defining characteristic is that a bi oregulator is a very short chain of peptide,

5:33 and peptids are these long chains of amino acid. That's the best way to kind of understand from a molecular level how they're different. Let's look at their mechanism of action. So basically, bioregulators can directly influence gene expression by binding to specific DNA sequences, promoting or inhibiting the synthesis of particular proteins. I know this is confusing, but I promise I'm going to bring it back down to level 101 in a second. The peptides are highly, so bi regulators are, highly tissue specific, meaning they target specific tissues or organs.

6:04 enhancing their regenerative capacity. So again, with bioregulators, we're looking at them specifically healing an organ based on whatever their structure is. There is a bi oregulator for your brain, for you heart, your liver, kidneys, pancreas, all those different organs, prostate, testicles, ovaries. And then there's this idea with bioregulators is as much more about homeostasis. So by restoring the natural balance of protein synthesis within cells, bi oregulars basically help bring the cell back into homeo stasis,

6:34 so they basically support the body's intrinsic ability to heal and regenerate, promoting recovery and optimal function without pushing the system beyond its natural limits. Think of bi regulators as more of a modulator. Meaning that if you have, for instance, a liver that's suffering from disease, non-alcoholic fatty liver disease. There is inflammation and problems with your liver. A bioregulator that heals the liver would go specifically to work on the lever to bring inflammation down in the lower. But if it's not going to swing too far to the other direction.

7:06 So if we looked at the immune system, your immune system could be in overdrive, or it could under-activated. A bioregulator helps bring the immune systems back into balance, and that's what a bi-regulator does for organs, it helps to bring them back in balance. So for instance, don't quote me on this, but I believe this was epitalon, which is a bio- regulator. In Russia, they use it on people that were much older, like in their 60s and 70s, and people who were younger, in like their 20s or 30s. And basically epitalin is the pineal gland bioregulator, so it helps the pineapple gland to optimize function, which is crucial for melatonin production.

7:44 So older people typically have less pinegal gland function hence they produce less melotonin, whereas younger people don't really have a problem with that. In the younger people, they actually didn't really produce any more melatonin at all when using epitalon, versus the older people actually used, or when they use epitolin, actually increase the melotonin production. So again, it's not that it told the pineal gland to produce more of melotonin. It's that, It helped bring it back into balance to optimal function of wherever it was, which is pretty cool because so many of like the pharmaceutical

8:15 interventions we have today are just like swinging the pendulum in one direction within the body. And that creates all these things. That's why so may people have and medicines for the side effects of one medicine that they're taking. So anyway, it basically is all about homeostasis. Now, if we look at peptides are slightly different. Peptides typically exert their effects by binding to receptors on the surface of cells, initiating a cascade of intracellular signals that lead to various biological responses. So while some peptides can be tissue specific, many have systemic effects throughout the whole body.

8:46 So they influence multiple organs and systems within the body, so peptide often have potent biological actions and their systemic affects can lead to significant changes and functions of the bodies, which if not carefully controlled, can result in overstimulation or adverse effects. For instance, let's take a GLP-1 peptid. You can take too high of a dose of this peptde and it will cause very unwanted side effects, That's why there's so many people that have an outcry against these peptides because a lot of people are taking 10 times the amount that they really should.

9:17 So that's what peptide do. Again, we can use them to get very, very good outcomes in the body, but they have to be used properly and they don't focus on homeostasis as much as bioregulators do Now, let's look at this modulation for the systemic effect. So basically, bioregulators have modulating effects, like I talked about. They enhance the body's natural processes rather than forcing an artificial response, making it difficult to ever overdose in the conventional sense.

9:47 Now I'm sure, yes, you could overdose on a bi oregulator, but it would be much harder than your traditional peptide or pharmaceutical medication. They also have self-limiting action, which means that the body's regulatory mechanisms ensure that once homeostasis is achieved, the activity of bioregulators diminishes. So basically they come in, they do their job, and then they're no longer there. This self limiting action prevents excessive responses, Which makes them even more safe than peptides. However, with peptide we have a systemic effect which leads to overdose potential.

10:18 Due to their potent systemic nature, peptides carry a higher risk of quote unquote overdose. Not what I mean overdose in the sense of you're going to overdose like you would typically associate someone like having a fatal event or anything like that, but they can lead to an imbalance in physiological processes. So the effects of peptide are often dose dependent. Small doses often in times will produce therapeutic benefits while higher doses can leave to unwanted side effects. This necessitates careful dosing and monitoring. Some peptides can accumulate in the body and their effects might build over time, pushing the systems beyond normal operating range,

10:53 which ultimately, not always, but ultimately could potentially result in negative health outcomes. So peptide, we just have to be smarter about how we use them, how do we dose them? How we cycle them versus bioregulators are typically going to not have that same response because of it working to allow the to do what it naturally does better. That's a lot of how they're different. Now let's look at therapeutic applications. How are they different in terms of applications in the real world? So first with bioregulators, we have regenerative medicine. So they're used to restore function and regenerate tissues in aging or damaged organs, which people often have as they age.

11:28 And they are commonly used in anti-aging treatments to improve the function of endocrine, immune, and nervous systems. And then also they can be applied in therapies for disease treatment, including neurodegenerative disorders, cardiovascular disease, and autoimmune conditions. So think a lot of these problems that we have in organ specific issue, bioregulators are very powerful in that sense. Let's look at peptides. So peptide are going to be much more efficient at things like hormone replacement, not testosterone replacement.

11:58 But we can look a growth hormone placement. Growth hormone releasing peptids like ipamrelin or tessamerelin or IGF-1. I know these are all a little bit different classes, but for simplification purposes, those help to replace lower levels of growth on the body. They basically stimulate the bodies natural production. of growth hormone to increase it. So we also have healing recovery. BPC-157 and TB-500 help heal wounds and repair tissue. And then we have things like metabolic health.

12:29 Obviously, this is all the rage right now with GLP-1 peptides or GLp- 1 agonists like semaglutide, which are used for weight management and diabetes treatment and also autoimmune disease and a host of whole other conditions that we're starting to find out really well right know. Peptides are amazing. But they have more of a broader systemic effect on the body, whereas bioregulators have a more targeted action. So both are good, they just have different outcomes and different effects. Now, let's look at the safety, because everyone's like, okay, I think we're moving in the direction of people understanding that peptides are really safe.

13:02 But if that's ever concerned with bioregulators, it shouldn't be because they're even more safe than peptides. So bi-regulators are generally considered safe with minimal side effects due to their natural origin and specific targeting. And they are shown to be effective in clinical studies for various conditions. Obviously, we need more research outside of Russia because there's tons and tons of research in Russia that we just don't really have access to yet. Then peptide, the safety kind of depends on the peptid. Now, peptids are more or less very safe. But when it comes to understanding dosage, cycling, all that stuff, you have to be careful.

13:34 And this is where, You know, someone could overdose on melanotan too, and get a freepasm and have a really severe problem with that. I've heard stories of that, so you had to careful with the dosing with peptides. and although peptide are well researched and that strong evidence supporting their use in specific therapeutic. areas, we need more clinical research, I guess, to kind of show people that are not as alternative health focused and minded to be able to understand. So both are very safe, but I would say by regulators, even more so because of how they modulate systems in the body and organs rather than,

14:07 you know, create certain outcomes. Now let's look at the regulatory environment and accessibility. So what's cool about bioregulators, and this is why we were able to sell the regenerative cream, is because it falls under the classification of a dietary supplement or a nutraceutical in many countries. You can get them as prescriptions, but for the most part, these things can be bought and sold very easily. There's obviously more research that we need in a, you know, Western world to be able to understand them. But when it comes to peptides, they're oftentimes classified as prescription medications.

14:41 Now I know I don't really talk about them in the context of prescriptions, um, You know because you can buy them for research chemical companies or whatever, but for all intents and purposes, I would never recommend anyone to take a peptide without the consent of their doctor because for the most part they are medications that are prescribed and have regulation around them So they have been much more extensively studied here in the United States than bioregulators have. But that's just kind of the distinction is bi oregulars can be classified as supplements, whereas peptides are more often than not can classifieds as pharmaceutical medications.

15:13 Now let's look at the route administration. Everyone's favorite. So what's cool about bioregulators is that they typically can be administered orally or sublingually, and then also through injections and creams. At least this is one thing, because I think I'm on the forefront of education in the peptide space. I realized that maybe 10% of the whole population will ever inject something into themselves, let alone get it from a research chemical company and injected

15:43 themselves at home. So I realize there's like only going to ever be so big a market for that. But if you for instance, look at the topical pain relief cream market, Most of which I would say are probably useless, you know, at least in the sense of giving you actual healing. Last year, there was $3.3 billion spent on just pain creams alone in United States. And obviously, almost all of those are over-the-counter medications because you don't have to inject them. You can use them as a cream. you can take them orally. So they're widely accessible as over the counter supplements in most countries.

16:14 Whereas peptides are often administered through injections due to their poor oral bioavailability. And again, that goes back to that amino acid chain length. When a amino-acid chain is too long, it will get broken out in the digestive tract, therefore rendering it useless because of the sequences needed to have the therapeutic effect. So some are available in oral topical creams, but for the most part, peptide have to be injected to get the full effect from them. And with that, being injected requires a prescription, although they can be found through some research chemical suppliers.

16:45 If you know, you'll know as they say. Now, here's another thing I wanted to look at, which is basically just the idea of immune response and tolerance buildup within the body. So one thing, I always talk about is peptides and antibody build up, peptide and cycling to make sure you're cycling your peptidines. How do bioregulators stack up? Do we need to cycle or do we have the same sort of response to bi regulators as we do peptides? So bi oregulars are actually less likely to trigger significant immune responses due to their natural origin and compatibility with the body's systems.

17:19 So this minimizes the risk of antibody formation and tolerance buildup. And so the low immunogenicity, which basically that's what we're looking at, immunogenicity is the idea of like how much of an immune response does it create within the Because bioregulators have a low immunogenicity, it allows for sustained efficacy over long-term use, making them suitable for chronic conditions and anti-aging treatments without the risk of diminishing returns like we have with peptides. Now let's look at peptide because this is what I've talked about a lot. It's kind of the opposite. So we had the risks of an immune response.

17:49 Peptides, particularly synthetic or exogenous ones that are popular today, carry a higher risk as being recognized as formed by the immune system. So this can lead to antibody formation intolerance, reducing their therapeutic effectiveness over time. So basically what that means is, for instance, there's apatide, a GOP-1 peptide. People start taking it, they get great results for eight to 12 weeks. All of a sudden they start to notice the results aren't there. Basically the body is building up a tolerance to that foreign substance. Now, does that mean it's going to cause problems? No, but you will have to increase the dose or cycle off to get the same effect that you had the first time, And even when you get back on,

18:25 the first time you take terzapatide is always going to be the strongest it is within the body. That's just a fact. that's why we cycle it on and off. But most people don't do that. They just increase those, increase the dose, and increase that dose. And so before you know it, they're on 10 times a dose that they were when they started out. And you know, it's a slippery slope because as you increase the dose, obviously like I've discussed today, you run into a lot of these problems that can result in unwanted side effects. So to mitigate these effects, peptide therapies are often cycled and have or require careful dosing schedules rotation of different peptides,

19:01 or the use of adjuvants to modulate the immune response. I should actually probably make a video about things that you can do to mitigate the immunoresponse of peptide just so you don't have to cycle on and off again. Again, more research is needed for that one, but I think I could take that somewhere. We also have antibody formation. So as part of the immune response, the body can produce antibodies against the administer peptides. These antibodies bind to the peptide, which neutralizes their effects over time and potentially leads to reduced efficacy. And then we have tolerance development. The repeated administration of peptids can lead to tolerance where the bodies response to peptid diminishes.

19:35 Obviously, And the immune system's continual exposure to peptides results in a desensitization process, which again, renders the peptide less effective over time. So again that's why we have to be extra smart when it comes to peptides. Whereas with bioregulators, the risk of that happening is very low. Nothing I haven't talked about before, but it is cool to see that bi oregulars don't necessarily have be cycled the same way that peptids do. What I did just to sum things up and even people said they really liked the chart in the last one. I made a little chart that kind of lays all these out in summary.

20:07 Again, just summing up, so when we look at the definition, bioregulators are short-chain peptides from animal tissues. Peptides are a short chain of amino acids. So bi oregulator are shorter forms of peptide. Bioregalators work through a gene expression regulation, whereas peptids work though receptor interaction. Biregulars are highly tissue specific, meaning they work on specific organs. Whereas peptid are more systemic, they can't be tissue-specific for the most part, though they're more systematic. Biregulators are going to be used for regenerative medicine and anti-aging, whereas peptides can be use in a bunch of different things in addition to anti

20:42 aging like hormonal replacement, healing, metabolic health. Safety wise, bi-regulars are very, very safe. Peptides obviously that varies depending on the dose. Regulatory-wise, bioregulators are considered more of a nutraceutical or a over-the-counter supplement, whereas peptides are often almost always prescription medications. Bioregalators, again, are available oral, sublingual, cream, and sometimes injection, where as peptide are primarily injection. Then we have a low immunogenicity, which is basically just a lower immune response to biorespirators.

21:16 Where as, peptids have higher risk of antibody formation and tolerance buildup. Bioregulators definitely can be used over time for sustained efficacy without really having to cycle on or off. Whereas with peptides, we have the risk of reduced efficacy due to tolerance and antibodies. And then basically biore regulators have a modulating and balancing effect, whereas peptide has much more of a systemic effect with overdose potential. And then like we talked about, there's that chain length. So bioregulators have very short chains, two to four amino acids, whereas peptides are typically three up to 50 plus amino acid.

21:51 That is it for the slides and that's the summary. And that is the difference between bi oregulator and peptide. As you can see, a lot of similarities, but also a lotta differences. Like I said, if I have anything to do with it, basically what I'm working on behind the scenes right now is to bring a broader exposure to the market here in the United States with bi regulators. So stay tuned for that. They're really, really exciting though. I think in terms of application, there's something that's going to be much more widely available. Obviously, because you go around the injection barrier, you don't have to worry about injecting them. But I people will be more comfortable with the idea of a bioregulator.

22:22 And I also think, as we've already seen with Regenivive Cream, some of the results are truly amazing. You know, I think pound for pound, uh, something like a regenerative, which is a bioregulatory cream has more healing properties faster than even PPC or TB 500. And I know that's a bold claim, but it's definitely something I've noticed in my own life. That's it. If you guys have questions, comments, concerns, definitely drop those below. Make sure I get those all into my queue for the Q and a videos.

22:53 Any questions about bioregulators. I'm looking forward to them because we're just scratching the surface. So as they say, we'll just getting started, baby. When it comes to all this stuff, but I appreciate you much love. Don't forget to sign up for email list down below, and then also too, if you want to be in a private membership group, head over there. It's $99 a month. You can cancel any time. And I think that's for today guys. Appreciate you. Much love and I will see you next time peace.