The Peptide Stack for Kidney Health

0:09 Hey everybody. This is Hunter Williams. I hope you're doing amazing wherever you are in the world. Today's video is going to be about the peptide stack for kidney health. As always, when I am doing a stack video, I just want to preface this and say that this is my best attempt at putting together some peptides and different drugs and medications around specific issue. In this case, it's kidney disease or CKD, chronic kidney, disease, or even just kidney malfunction or dysfunction that you may have.

0:39 So this is not exclusive. There are other agents out there that I'm sure do as good, maybe even better, but this just my best practices based on what I've seen. A lot of people that have worked with and just being out in the wild, so to speak, in a peptide world, I didn't realize when I got into all this health and biohacking stuff, really anything about kidney health, and I would definitely, I'm not an expert by any means. But when started working with people and publishing content and getting feedback from people, saw how big of an issue kidney is.

1:12 And I don't know the number off the top of my head, but I know millions of Americans and probably more millions around the world are affected by kidney every year. we don't talk about because it's not heart disease or cardiovascular issue related or cancer or something like that, but it is still a massive issue. And it s one of those things like if it gets bad, it get s bad fast for a lot of people. So today I wanted to take my best attempt at putting together some things that I've seen that work really well for kidney health and just people that i've

1:43 spoken with and been around in the peptide world and put that together in a comprehensive format for you guys to see. And again, this is not the end all be all. I am not an expert on this. Definitely not a doctor, not any of those things, but I have seen these things work. So there's other things that you could do in addition to this that I'm sure are great. There's probably even some things that are even better than what I'm going to talk about today. But again, it's just my best practices. And again kidney health is such an important part of our overall health. It's one of those things. That doesn't get as much attention or publicity, but is affecting millions of people.

2:15 So it deserves to have some attention. Then obviously too, when we talk peptides, there are things can absolutely help that would be beneficial to someone suffering from kidney issues. That's what today's gonna be about. Again, before I get into it, make sure that you're on the email list, that's going to be the link at the description of the video, wherever you are watching it or listening to it on iTunes or Spotify. Check that out. Make sure you sign up for the e-mail list. That the best way to stay in touch with me, to make that sure don't miss any content or if I could deleted off of more platforms, That where I can go to let you know where am going be in the future.

2:46 For instance, with YouTube, if have to start a new YouTube channel, because my other one got deleted, I tell all the people on my email lists so they can see my YouTube videos now. So it allows me to be in contact with you and I also send out information based emails that are either summaries of my videos or other things that I'm working on that. I think are helpful to people and there's ads in it. Sure. But the purpose is not to sell you is just to provide more information and other channel do so. And the good thing about email is that, I have it as a one-to-one connection with us, not based on a social platform that they can delete me off of.

3:17 That being said, let's jump into today's video and we're going to talk about the peptide stack for kidney health. All right. Let's get into it today. I'm going to talk about the kidney health peptide stack. It's going be a 12 week protocol. Some of the things are going going, but I put renal longevity on there. Obviously reno means kidney. When we look at longevity, kidney, health is an extremely important piece, maybe even a cornerstone of longevity. Dare I say. So when we looked at kidney help, whether or not you have a kidney disease or something wrong with your kidneys, I think it's still relevant as it is something

3:50 that we look at as we age to make sure that kidney health is in good standing, at least as much as can control it, right? Now let's look a kidney vulnerabilities in aging and chronic disease. Fun fact, the kidneys are highly metabolic organs consuming up to 10% of the body's oxygen, which is kind of crazy when you think of all the organs we have in our body and the kidney's consumed 10%, to fuel filtration and reabsorption processes. And basically, this intense energy demand makes kidney cells especially prone to oxidative stress damage as we age.

4:25 The more stress and oxidate of stress that gets put on the bodies as age, more it takes a toll on kidneys. When we look at aging and chronic disease, excess reactive oxygen species, otherwise known as ROS, accumulate while antioxidant defenses go down, triggering progressive injury to proteins, lipids, and the DNA inside of our kidney cells because the kidneys are responsible for so much of this filtration and reabsorption that the body needs to do in order to stay alive.

4:59 And when we look at kidneys, we have first mitochondrial dysfunction, so dense mitochondria population in the kidneys creates vulnerability to oxidative damage and energy depletion. Then we obviously have cellular senescence, that's the big buzzword, cellular Senescent zombie cells. Arrested cells secrete inflammatory and fibrotic factors which promote chronic inflammation. So we're going to want to suppress some of those. Then we have, forgive me if I don't pronounce this right, but it's glomerulosclerosis, which is the scarring of the glomerolyte which leads to a loss of

5:31 filtration capacity over time. And then obviously we had metabolic stress, hypertension, high blood pressure, and hyperglycemia, a high-blood sugar accelerate injury through hyperfiltration and mechanical stress on the kidneys. Basically if someone has high pressure high, blood sugar, insulin resistance, diabetes, that's going to put a lot of strain on the kidneys because they're working overtime in order to keep you alive. And so when we look at all of these stresses from our life, the aging kidney faces a perfect storm of mitochondrial dysfunction,

6:03 oxidative stress, inflammatory signaling, fibrosis, and hemodynamic strain all converging to erode kidney function. And when we proactively address these vulnerabilities, it's critical for preserving kidney health and longevity. And again, so whether or not you have kidney disease, all these things that I just talked about are kind of something that we're all under assault from as we age. Now, when look at building the stack, I basically build it into five agents. I like to keep my stacks around five peptides. Sometimes you need more, sometimes you less. But in terms of addressing issues, the five because it's not too much, it not to little.

6:38 There's usually enough that can be done from five peptides that will help. And then also too, is not so much the person has to administer three shots a day. Now, when we look at like addressing all the areas, right, because like one peptide might address certain things and other peptides might do certain thing, what are we going to look out? We're going look first mitochondrial production, we're gonna look SS31 for that. We are going at hemodynamic relief and we are gonna talk about Jardience for basically to help preserve filtration barrier integrity. And so Jardians is going to be a big player in that.

7:08 We have antioxidant defense, we've got glutathione for that, and we're going talk about that tissue repair, ARE290. You may have heard of that or seen that on research sites. Pretty cool. I haven't talked about it that much, but I wanted to talk it today. And then metabolic optimization, We're gonna talk MOTC for how it could be beneficial for the kidneys. Let's first look at one of my favorite peptides of all time as it stands today, SS31. Now, you probably, if you listen to my stuff, know about SS 31. I talk about it a lot because I love it. However, the dosing, as you see, is kind of over the place.

7:39 It actually just got FDA approved and the dose for that is 40 milligrams a day intravenously. Obviously, If you don't have Barth syndrome, which is what SS-31 is approved for, You probably don' t need that much. probably need one or two milligrams a day just for optimization purposes. Now, when we talk about chronic kidney disease, kidney wasting, all of these things that can arise from a damaged kidney, I like somewhere around the 10 milligrams per day injected subcutaneously.

8:09 How did I arrive to that conclusion? One, well, a couple things. One I've seen results for people in that. So it's obviously more than the one or two milligrams that like an optimization dose would be. Although there's still benefit if you're healthy to use that dose of one to two kilograms. But when we look at kidney disease, we're going to see a much faster, more pronounced effect of that 10 milligram a day. Now you could go higher, you can go to the 40 milligrams a day, but for a lot of people that becomes very cost prohibitive, at least as it stands right now.

8:39 I like 10 milligrams per day. You can do it five days on, two days off, every day if you wanted to for 12 weeks. And again, I know a lotta people are gonna put it in their wallet, it's the most powerful thing in the stack. So SS31 is a mitochondria targeted peptide that enhances electron transport efficiency while reducing RS production. It preserves ATP generation, prevents tubular cell death in the kidneys and dampens inflammatory signaling in stressed kidneys. Its going to stabilize mitochondrial function, reduce oxidative stress at the source, prevent tubule cell deaths, again dampen inflammatory signalling

9:11 and enhance cellular repair mechanisms. So when we look at SS31, to me, this is the front line. And there is actually published data around SS 31 improving kidney patient outcomes. I forget specifically around what it is, I just filmed a video about that. But we do have studied data clinically and where SS-31 has been used to improve kidney health. Now, you probably thought of Jordians as a diabetes drug. Well, when we talk about kidneys, there's a lot of connection between insulin resistance and kidney health.

9:46 But Jordiens, I love it. 25 milligrams a day, orally. I would actually take this for the rest of my life. So far as it stands, i plan to use this the for rest my because of how good it is. Basically, Jordians reduces glomerular hyperfiltration by restoring tubo glomular feedback, lowering intraglominal pressure and mechanical stress, and this preserves podocyte integrity and prevents glomenal sclerosis. In short, basically Jordian is taking stress off the kidneys by blocking the reabsorption of glucose.

10:17 And so we're taking a load off of kidneys. Think of like walking around with a 60 pound weight vest on, how tired that would make you. And people that are diabetic, their kidneys are basically doing this. They're shouldering a load. And then we take that off. That's what Jardience is doing by blocking the reabsorption of glucose in the kidneys. What it also does is it triggers myocytosis and lowers cellular glucose, which activates AMPK. This shifts metabolism towards burning fats instead of sugar. improves mitochondrial function and shuts down inflammatory pathways that cause scarring on the kidneys.

10:49 And there is clinical evidence that we have today showing that they help kidneys work better for longer. They reduce protein leaking into urine and slow down kidney damage. The longer you take them, the better they protect your kidneys, which is why I would say don't cycle this, just use it all the time. I've seen numerous people just take Jardians and have massive improvements in their kidney health. And so I recommend it to everyone, amongst other things for the longevity benefits, but also for kidney benefits. Next, we have glutathione.

11:19 And when we look at all of that oxidative stress that's happening on the body, this is where glutothione comes in because it is the best antioxidant that I know of, that we access to. What I like is 200 milligrams intramuscularly three times a week for at least 12 weeks. You could do a higher dose, like 400, 600 milligrams, but I think for most people, assuming they're doing the other things that talk about in this protocol, it would be good. Basically, glutathione is our master antioxidant. It neutralizes harmful free radicals. As we age, our endogenous glutothione levels drop, which leaves the kidneys vulnerable to damage because they don't have protection against some of that

11:55 oxidative stress. And then supplementing restores this defense system which protects kidney cells from oxidant stress and preserves function. Again, if you just do it three times a week, 200 milligrams per dose, alongside the other things we're talking about, I think you're gonna see really positive benefit and impact. Maybe a little bit of a wild card if you're not familiar with it, but I'm going to talk about why it's relevant. ARE-290, the clinical name is subbinotide, is a tissue repair activator. And what I like for this, clinically, they usually use it for four milligrams for diabetic neuropathy.

12:26 So I think you could do a lower dose for kidney health, But hey, if can afford four-milligrams, knock yourself out. There's no downside to taking that. But I say two milligrams daily sub-Q for 12 weeks. Are-A2-90 is made from a hormone called erythropoietin. You may have heard of that, that's what like Lance Armstrong was using. but it's a modification of that to not have the same side effects that that performance enhancing drug had. But basically it helps repair damaged tissue and reduces inflammation without making too many red blood cells. It also works by turning on the body's natural healing systems. That works on something called the innate repair receptor to stimulate and agonize that, to help us repair.

13:02 When we look at ARE-290, it has remarkable protective effects and models of kidney ischemia reperfusion injury, improving kidney function and reducing acute tubular injury. So there is data around that to show us that it works well. It's also anti-inflammatory, so it dampens inflammatory cytokine release and vibrotic responses via the innate repair receptor, the IRR, that I was just talking about. In the finance world, side note, IRRR stands for internal rate of return. not in this case, but in vascular support, it also supports endothelial health, mitigates ischemic damage and may promote regeneration of micro vasculature,

13:41 which is really good for someone that has a damaged kidney. So essentially it provides the tissue healing benefits of erythroproletin enhance cell survival, reduce fibrosis without the side effects of EPO. It also helps interrupt the cycle of injury, inflammation, fibroids, and the renal tissue by acting as an anti-inflammatory. Again, ARE-290 great for nerve pain, great diabetic neuropathy, but when we look at kidney health, we can absolutely use it to improve through some of those things. And I think when you look like the action, Not too different from a BPC or TB 500, which would be good to use in this case,

14:17 but I think specific to the kidneys, probably going to stand to gain a little bit more benefit from the ARE-290. Most people know this is a fat-loss peptide. I like the dosing around one milligrams per day daily subcutaneous injection for 12 weeks. If you want to do five days on two days off, that's totally fine. Most people again think of this as a fat loss peptide, but when we look at kidney disease, a lot of times it can be linked back to this oxidative stress that is placed on the kidneys through a metabolic burden.

14:48 And MOTC is a mitochondrial derived peptide encoded into the empty DNA that functions as a systemic signaling molecule. It translocates to the nucleus under metabolic stress and orchestrates an adaptive gene expression response. Again, it's doing this in the body, kidneys as well. It's a potent activator of the AMPK pathway achieved in part by inhibiting the folate cycle and causing the accumulation of ICAR. And by activating AMPk, MATSI enhances insulin sensitivity and metabolic flexibility, which then promotes fatty acid oxidation,

15:18 reducing fat deposition and improving glucose uptake. Then we look at it for longevity. It upregulates endogenous antioxidant defenses, Which we need for the kidneys, boost NRF2 driven gene expression, enhances mitochondrial biogenesis, improves insulin sensitivity, and reduces cellular inflammation. And when we look at MOTC, We notice that people with chronic kidney disease have very low levels of MOTSY, which obviously contributes to metabolic disturbances. Restoring Motsy via an injection therapy can mimic some benefits of exercise in youth.

15:52 And in essence, Motsy recalibrates cellular metabolism at every level and stress responses acting as a longevity factor that counters the metabolic and oxidative derangements of aging. And when we look at kidney disease, again, this one is not going to be so specific and working in the kidneys, but it's going be more upstream. So it is fixing some more of those upstream problems that would lead to all of the stress on the kidney, which will then take the burden off the kiddies. And a lot of times, think about the kids carrying that load, shouldering that weight vest.

16:22 We want to be able to take that off to let them do what they do. And if we're constantly throwing more weight and more and weight on the base, eventually it's going to give out. That's where people get CKD and some of these problems with their kidney health. When we look synergistically, let's just talk about how these are going to work together. SS31 directly fortifies the mitochondrial structure and function in the kidneys, prevents electron transport leak that produces reactive oxygen species, and in aged kidneys eight weeks of SS 31 will produce mitochondria structural decay in kidney cells that reduce markers of cellular senescence.

16:55 Again, MATC activates AMPK and NRF2, which upregulates the cell's own antioxidant enzymes and mitochondrial quality control mechanisms, and it heightens resistance to oxidative injury and improves mitochondria turnover via mitophagy. Then we also have glutathione, provides broad spectrum RLS neutralization in cytosol and Mitochondria, maintaining redox homeostasis. when stress is high and it resers residual oxidants are swiftly quenched and together they dramatically reduce the oxidative stress.

17:25 So again, we have a multi-pronged approach to oxidant stress when we look at glomerular structure and filtration, Jardiance reduces glomular hyperfiltration, it prevents mechanical injury to podocytes and capillaries, lowers intraglominal pressure, means less shear stress on the filtration barrier and reduce proteinuria, again taking some of that load off. Again, SS 31 through supporting mitochondrial health research. In Old Mike showed SS-31 improved podocyte cytoskeletal integrity and increased glomerular endothelial cell density.

17:58 So again, helping is with the structure of those kidney cells. And then the ARE290 is going to promote micro vascular repair and endothelial nitric oxide signaling, which can improve glomerular perfusion without raising pressure. And so we have multiple angles to attack this. Again, that's why I put this together to help our kidneys stay young. So we look at it, we want to remove the triggers, reduce inflammation, suppress oxidative injury, block fibrogenic pathways, and promote clearance.

18:28 all of those things working together, that's what it's going to do. And aging kidneys expect slower fibrosis progression and even reversal of early scarring. Studies show SS31 reduces fibroblast activation and glomular scaring and the stack that we have together breaks the cycle of inflammation of fibbrosis that drives kidney aging. And again, when we talk about a lot about this is mitigating metabolic stress and improving resilience. So we want lower blood sugar spikes. We want higher fatty acid oxidation. we wanna activate autophagy by removing dysfunctional components.

19:03 We want to reduce metabolic exhaust, which is driving the oxidative stress. And we want an ameliorate or make better kidney, cortical hypoxia. Jordy and Tsumasi work really well in terms of like the metabolism to help with those things. So again, we're taking the load off. Some things just to monitor, we wanna monitor glomular filtration. So that would be serum creatinine and EGFR. We also wanna look at urine albumin to creatine ratio, which is known as UACR. You also want to look fast in glucose, A1C.

19:33 Fasting insulin is also very important. A lot of people leave off fasting insulin when they're talking about this stuff. C-reactive protein is very also important to looking at. High sensitivity, HSCRP would called on the blood work. And then also too, we can mark NGAL, which is neutrophil gelatinase-associated lipocalin, or CHIM1, and then, also, monitor electrolytes in uric acid when we're using Jardine. It's just something to be aware of. So those are the things that, if you want a screenshot, you would look at on blood work. And so, in terms of cycling recommendation, We've got 12 weeks of the SS31ARA290 and Mod C.

20:08 We obviously have the glutathione. You can pretty much use that year round at that dose, 200 milligrams three times per week. The Jardians, I would say just for life. If you have kidney issues, you want to be on them for the rest of your life, but even if you don't, there is a benefit, to being on it the next year life then kind of evaluate where things are depending on how severe or not severe that you may be. And then I think for someone that struggles with kidney issue, You could absolutely run this twice per year. Stay on the Jartians. I wouldn't even say stay on glutathione, and then the other ones we can cycle strategically throughout the year to help.

20:41 And this idea obviously aligns with hormesis providing the stimulus for repair and allowing for recovery. Then when we have 12 week therapeutic bursts to work on restoring kidney function, we could kind of take some time off rebuild sensitivity to those peptides so they work better. You can obviously always titrate up the dose. So you don't have to cycle off, you know, that's kind of one of the things I was talking about is like, You don' have too, but you're going to have titratate up dose to get the same effect. And then Jardience is obviously helping a lot for the long term. Just as a summary table, I'll leave this slide up for a couple of seconds.

21:12 I have to leave my camera on there because it's filming. But if you want to take a screenshot of that, that has the doses with everything on their and then why you would benefit from them. on Jardians. We have data on ARAT90 to reduce damage around some of these parameters. we want to focus on kidney disease before it starts. So if you notice things like your GFR slipping, if your HSCRP rising, If you noticed some these things getting off, get out in front of it.

21:45 Don't let it get so bad that you get CKD, that an issue with your kidneys that have to be hospitalized for. And then ultimately, whether we have kidney diseases or not, all of the things that we talked about today can be used for longevity purposes. And a side benefit is that they help our kidneys. So when we look at that, part of protecting the kidneys is doing a lot of that stuff upstream that I was talking about to stop the oxidative stress or take the load off the body. And these things, when we use them together, we'll do so. So again, that's why I like to approach these thing from a multimodal.

22:18 When we look at kidney health, there's a couple different things that go into it, right? And so how can we used peptides to address those? Again, not exclusive or not limited, but in my opinion, those are some of the things I've worked well. And that is it for the slides. And there you have it folks. That is the peptide stack for kidney health. Again, there are other drugs, peptides, supplements, everything out there that does work well for a kidney that are beyond the scope of this video. But I think if you just took 12 weeks and did those five things that I talked about, you know, if have severe kidney disease, it's going to heal everything.

22:48 No. But if you are in that borderline where like something may be going on, these absolutely will help get things trending back in the right direction. Take some of that stress off the body. I think when you look at kidney disease, like I said, the best analogy is like we've had this weight. We've been walking around with a barbell with 45 pound plates, a 60 pound weight vest on our back. And the kidney, eventually, if you just keep doing that and keep going that, it's going to give out. It's gonna strain and give it out, and we want to restore some of the things that are going on at a cellular level to help the structure of kidney cells,

23:19 but then we also want take some oxidative stress off the body. We want some metabolic stress of body to take help. And so hopefully this was helpful, maybe even a little entertaining and educational at the same time. Again, thank you guys so much. If you or someone you know suffers from kidney disease, help send this their way because these are all relatively easy things that you can relatively do affordably and kind of in the purview of your own stuff and maybe outside your doctor, not the doctors are bad. And there's some doctors obviously know way more than me about the kidneys and also probably have better protocols than this.

23:51 But I think it's one of those things that if you're kind of on the fringe in medicine 3.0, you can use a lot of these things to your advantage and do them in a relatively affordable way on your own. That's it for this one. Again, thank you guys so much. I have so many gratitude in my heart. For everyone out there that supports the channel, or whatever this is now on Spotify, I guess it's a Spotify channel podcast, maybe one day I'll be back on YouTube still waiting to hear on that. But thank guys, so it means the world to me that I get to bring these messages to you, help you with this and whether that's being on the email list,

24:24 using my codes, places, liking, sharing the videos with friends and family or whoever it is. Thank you so. It means a world that I get to bring this information to you. So I cannot thank you enough for that. And I have so much gratitude in my heart. Hopefully that comes through in the material. I just always want you guys to know that so that's it for this one and I will talk to the next one. Peace.