Cartalax Review: Faster Healing Than BPC-157?

0:09 Hey everybody, this is Hunter Williams. I hope you were doing amazing wherever you are at in the world. Today's video is going to be all about cartilax, which is actually the injectable cartilage by a regulator. So to give you a little bit of background on this, these injectible bioregulators have been around on various research sites for a few years. And in community, it was really hard to find data on how to use these. Now they've been used in Russia for many, many years, But a lot of that literature is in Russian and has been translated to the US and it's also hard to

0:40 find because it is not online or some different places. So, anyway, being the guinea pig that I am, I decided to order a bunch of these and compile some dosing parameters for which I experimented on myself. Again, as far as dosings on these injectable bioregulators go, first of all, they're very safe and they are just amino acid sequences. In terms of response, especially relative to some other chemically strong signaling peptides like GLP-1. They're very, very safe to use and they work as modulators. So at the very worst case, they're just not going to do anything.

1:10 The very best case they are going help bring whatever tissue they working on back into homeostasis or modulate to work to bring it back in balance. But I started compiling just some use cases around myself and I also updated the peptide cheat sheet to have all of the new dosing for these injectable bioregulars on there. And so you can always check that out, download it. You should be able to download it even if you've already opted in. You can opt in again. It'll send you a new one or you can just be on my email list and it's always on there in the footer of my e-mail list. But anyway, I started to put together some data around these and one that I had been using was cartilagin.

1:41 Like I said, this is cartilage by a regulator. So I was like, okay, This could be interesting to see. And what I did first was started using it systemically. I just injected it sub Q. And the first few times I didn't really notice anything. Now, granted, I don't have any, what I would say is cartilage issues. So I feel very healthy all the time. Right now I have no injuries. I do not have soreness in my joints, my knees, elbows, shoulders or anything like that. The first days I did not really noticed anything, but What I did do was one day I was training and when I used to play football,

2:12 my wrists were always sore, right? Because I wasn't a linebacker, I tackling people, hitting people taking on blocks and my wrist would be sore all the time when it's playing football. They don't really bother me anymore. And of course I've used peptides through the years to help heal them. But there was a gym session I did where I was doing a chest press with dumbbells and both my wrists were really, really sore after it. So much so that the night before I went to bed, I'm like, man, my wrist are sore. And I said, okay, well, this will be the perfect opportunity for me to have a use case for cartilages to inject into one wrist and see how it feels because

2:42 they both kind of felt the same. and then see how my other wrist feels. So the next morning I got up, my breasts were still really sore and I was like, okay, here we go. I did two milligrams, which would be kind of the starter dose for cartilax into my wrist. And I'm not kidding, I am not exaggerating this. You can buy cartillax from BioLongevity Labs or buy it from anywhere else. so I m not trying to shill for this product, but within 20 minutes I had full range of motion in my wrists and the pain was gone. And if you know anything about BPC and TB 500, typically those take at least a day or two before you notice a pain relief or improved feeling or sensation

3:13 or range of motion wherever you have injuries and they work really well. But this was unlike anything I had ever seen. I was like, okay, that's crazy. as fate would have it. Later in the week, I was doing hack squats and I kind of pulled a muscle like in my upper back, which I do from time to time, you know, whenever, it comes with the territory when you're doing hacks quads, but it was just having a little bit of a muscles spasm in like my back and it's like, okay. And I got Taylor to inject another two milligrams of cartilagin into it to see how it did again, 30 minutes to an hour later, the spasms were gone.

3:43 There was no pain. The next day I woke up. and I had no pain in my back. And usually I'll do the same thing with BPC and TB 500, but it takes a day or two again before it really starts to go away. So I was like, okay, something serious is going on here with this. I really need to make a video explaining this to people because I honestly think in This could replace BPC-137, Bpc-157 and Tb500, or at the very least, complement them to where you could inject alongside and probably get a little bit more immediate relief. So, Cardilax is very, very powerful. I'm going to explain everything about it today, including the dosing, so stay tuned.

4:16 And as always, check out the Peptide Cheat Sheet. We've got the Dosing for Cardillax and all of these other injectable bioregulators on how you would use them down below. For use case of an injury, you can use Cardalax. right away. But then there's also probably some systemic benefit. Like I was saying, I have injected these sub Q and I didn't notice anything, but again, didn' have any systemic cartilage issues or damage. Once I decided to inject in my wrist where I did have some issues, it came back and did really, really well.

4:46 So that's what we're going to talk about today. I hope you are as excited as I am. Don't forget, check out the Peptide Cheat Sheet and also Fully Optimized Health, the best community on the planet. And without further ado, I'm going share my screen and today we are going learn about Cardilax. All right, I'm Hunter Williams and today's video is all about cartilax and the subtitle of this one is, is it better than BPC-157? I think it's right up there with it and if not better. So let's just look at the background. Cartilaxis is an injectable short peptide classified as a bioregulator, meaning that it helps normalize specific tissue functions at cellular level.

5:21 Again, like almost all the bi regulators, it was originally developed in Russia and was designed to target cartilage and bone tissue and is often used in both medical and biohacking contexts. and it is one of the cabins and peptides of which we sell at BioLongevity Labs and is touted for its anti-aging and regenerative potential. Today we're going to look at all the mechanisms and dosage and benefits that we can expect out of cartilage. So let's start with the mechanism. It's a synthetic tripeptide composed of three amino acids. They are alanine, glutamic acid, and aspartic acid.

5:52 It was developed from cartilage tissues sharing amino acid sequences with collagen for structural support. So if you know anything about these, the injectable forms are not this, but they are modeled after the amino-acid sequences of the tissue that comes from bovine or porcine tissue in the animal to help regrow our tissue. Very similar to how people take desiccated beef liver extract or desiccated thyroid extract. It's very similar. In this case, we're using ones that are mimicking the collagen amino acid sequences that can help our collagen and tissue repair.

6:26 So it's available as an injectable lyophilized power or oral capsules. Again, the cartilagin that we have is an ejectable, but there is a oral capsule version that I think you can find. And also the other Oral capsule by regulator is known as Sigamir, which we also sell as well, but today we're going to focus on the injectable. but it utilizes dipeptide and tripeptide transporters in the gut and tissues for systemic absorption and targeting. And the way it works is it maintains stability for cell penetration and target effects before enzymatic breakdown when we inject it.

7:00 So it functions as a gene expression regulator and cell behavior modulator in connective tissue. It's designed to normalize the activity of cells in cartilage and bone by up-regulating repair processes and down- regulating destructive or aging-related processes, which would be inflammation, pain, and degeneration of tissue as we age. It targets fibroblast-like cells found in the cartilage, skin, connective tissue. In doing so, it boosts cell proliferation and regeneration while suppressing aging markers.

7:32 And specifically, it increases Ki67 and CD98HC levels. It inhibits MMP9 and suppresses capsaicin 3 activity. But those are basically just things that are going on that it does to help evaporate these processes. And in doing so, helps maintain collagen matrix integrity and reduces apoptosis for a more youthful state, specifically in our cartilage, which is pretty cool. So on a molecular level, it appears to interact with cellular signaling pathways and even DNA to exert these effects. So studies on this, which we're going to look at some today, have found that cartilagin can modulate the activity of key genes and pathways such as NF-kappa-B,

8:08 IGF-1, and P53. NF kappa B is involved in inflammation and cell survival which regulates inflammatory responses and joint tissues. Obviously, you guys know IGF-1, we all love IG-F1. We take growth hormone, peptides to increase IG F1 levels, to help with tealing, help tissue repair, and help fat loss. Cardilax helps upregulate the IG f1 gene, so it promotes tissue growth and repair. Stimulating cartilage matrix synthesis for regeneration. It also affects cellular senescence, which is pretty cool.

8:40 So it modulates genes related to longevity, promoting anti-aging and pro-regenerative effects at the cellular level. And also, along with other bioregulators that do this, it alters telomere-related enzymes and growth pathways for proper cartilage cell function. Specifically, when we look at telometers and cartilages, Cartilax is working directly on those. And then when we look at DNA binding, it binds to specific DNA regions, potentially acting as a gene regulator without a classical receptor, which is pretty cool. So when combine all these together, essentially signals to cells to enter repair mode, right?

9:13 If we have injuries or pain or soreness around some of these things. In cartilage tissue, that means chondrocytes producing more collagen. And, I'm not gonna butcher this word, proteoglycans, which are the building blocks of cartilage, and fewer enzymes that break cartilages down. So in various organs, the peptide's actions are considered bioregulatory, Which means that we're restoring normal balance. Whereas some of these other things are working to increase angiogenesis, i.e. BPC-157, we are actually helping bring inflamed tissue back into a more youthful balance state.

9:44 Which is pretty cool because it's a little bit of a different mechanism than, like I said, some other chemical signaling from peptides. But because fibroblasts and stem cells share common pathways across tissues, Cartilax has polyfunctional effects, which are not strictly limited to cartilage. So it's helping with cartilage mainly, but as we talk about in those mechanisms, it is also having a system-wide effect throughout the body. Improvement seen in skin fibroblast cultures hint that it could aid skin healing or elasticity, and effects in kidney cell models suggest a potential kidney protective influence. Nonetheless, its strongest reputation remains in joint and bone health.

10:15 That's where we're going to see the most benefit and want to use it for. and researchers have described cartilages both chondroprotective which protects cartilage cells and geroprotective which protect against aging. of this dual role in supporting cartilage integrity and slowing cellular aging. So in addition to helping heal injuries, I think for someone that's training as we quote-unquote age, this could be very, very beneficial just to maintain joint integrity, bone health, and all those things. Let's get into that. What are some of the medical and off-label non-medical uses of Cardilac? Its primary medical application is in support the musculoskeletal system, like we said, cartilage, joints, and bones.

10:52 And in Russia, it's indicated for a range of joint and connective tissue disorders. So it is more effective for both prevention and treatment of Joint Bone and Spine Disorders. Some of the uses from the Russian literature are the following. We've got degenerative joint diseases, so it helps to manage osteoarthritis and degenerate dystrophic changes in joints and spines, osteochondrosis or spondylisis. It's also considered a chondroprotector, like I said, or a cartilage protecting agent aiming to slow cartilage breakdown in people with these degenerative

11:23 joint diseases. And a clinical study in Russia actually reported cartillax was effective in comprehensive therapy, along with other things of spinal osteochondrosis and osteoarthritis. Pretty cool. What's so cool is some of the bone health. Again, this is one of leading indicators of whether someone is going to age rapidly, as many women do after menopause. is how healthy and integrous the bones are. So it improves bone density and healing, for example, in osteoporosis or after fractures when we have an injury. And it's been used to aid post-operative rehabilitation after bone surgeries and injuries.

11:56 It also can work in inflammatory and rheumatic conditions such as rheimatoid arthritis. So it works on arthritis and gout to reduce inflammation and pain in the joints. And it also, can be used preventively or just for recovery purposes. It prevents age-related deterioration of joints and spine and the elderly and mitigates the effects of heavy physical exertion. which I expose myself to on a regular basis, and hopefully you do too, such as athletic training or manual labor on the musculoskeletal system. So athletes have also used it for injury prevention and to support recovery for my high impact sports.

12:28 I think for someone that is a competitive athlete right now, this is something that you definitely want to cycle at least two to three times per year, probably not much more than that. And I'll explain that later, but it's going to help with protecting the connective tissue and preventing injury there just by strengthening it. It's also given to orthopedic surgeries. prior and during rehab to improve outcomes. So we can take it before surgery and after surgery to help with the recovery. In terms of the non-medical or off-label context, it's gained popularity among a lot of biohackers and anti-aging enthusiasts,

13:02 hopefully this video. does to bring it forward to the forefront even more. But because it is thought to regenerate cells and normalize tissue function, people use it basically as an anti-aging supplement. So it's classified as anti aging by a regulator by its developers due to its purported ability to reduce cellular senescence and restore function in older cells. And anecdotal reports include improved joint flexibility, reduced joint pain in aging individuals, and even benefits to skin elasticity or wound healing since cartilage and skin share very similar cellular components.

13:33 So in the longevity world, which is kind of our world cartilages sometimes combined with other bi-regular peptide support, overall regenerative processes, And I'm not going to go into that today, but that's going be something that I am working on in the future is kind of like, how do we combine these? I don't think you necessarily need to combine this with anything to get the intended effects that we're talking about, But there are some pretty cool studies and a body of evidence to suggest it would be cool. So let's actually look at some of the scientific and clinical research. So being a relatively niche peptide, the body of scientific research on cartilages is growing, but not extensive and probably never will be because it's

14:06 so cheap and so effective. But much of what is known comes from studies by research teams in Russia and Eastern Europe, often led with Professor Caventin's group. Rest in peace. So let's look at these. So early foundational studies tested cartilax on cultured cells to observe its molecular effects. And a 2016 study published in the Bulletin of Experimental Biology and Medicine examined cartillax impact on human skin fibroblasts undergoing replicative aging. Results showed enhanced fibroblast proliferation and reduced apoptosis with cartilage evidence by increased KI67 and decreased CAPSase 3 in treated cells.

14:41 Also, a 2015 experiment on organotypic kidney tissue cultures from young and old animals found that cartilax stimulated cell renewal in aged kidney tissues. Cells showed higher proliferation and lower levels of pro-apoptotic P53 when cartillax was added to the mix. And this reinforces the idea that the cartilla can rejuvenate aging cells across different tissue by modulating growth and death signals, which is pretty cool. So we also have a systemic investigation in 2020 which looked at how cartilax and other short peptides modulate gene expression in aging mesenchymal stem

15:15 cells otherwise known as MSCs. So the researchers measured genes tied to aging and regeneration in bone marrow MSC's that were stressed by many cell divisions or kept in a non-dividing state. so cartillax was found to upregulate IGF-1 and NF-kB gene expressions significantly in both models of MSc aging. So all three tested peptides in this study, including cartilax, at nanomolar concentrations shifted the expression of aging-related genes. Basically, they tuned the cell's gene activity toward a more youthful profile.

15:45 And another publication in 2023 in the International Journal of Molecular Sciences reviewed short peptide and cartilage repair and noted that cartillax specifically can activate pathways such as NF-kappa-B and IGF-1 that are relevant to osteoarthritis and relevant reversing and preventing osteoporitis. They ultimately found that cardiac shows chondroprotective potential in osteoarthritis models, helping MSCs differentiate into healthy cartilage cells and exhibiting geroprotective properties that make it promising for osteoporosis treatment.

16:16 Now, this is complete speculation on my end, but if you are someone who... administer stem cells or receive stem cell or is involved in that world, maybe cartilax can be a very, very powerful adjunct to help with the efficacy of the stemcells and helping the effectiveness of those when people use them. So definitely is measurable when we look at what it's doing from an expression level. There's pretty sparse published data on in vivo animal trials specific to cartillax. However, given that cartilage peptide sequence is highly conserved and very small, it is expected to function similarly in all mammals.

16:49 Some related peptide bioregulars have been tested in rodents for organ rejuvenation. For instance, epitalon for pineal gland aging in mice is very well studied. So, cartilax might have similar regenerative effects on joint tissues and animal models. There's also something I found in a Russian patent from 2008 for a peptid normalizing metabolism in bone and cartilage tissue. Essentially, the development of cartillax, which likely included animal testing data for efficacy improving joint health. Again, not a lot on animals. When we look at human trials, There is some good data around them.

17:21 So a clinical study cited by the manufacturer involved patients with chronic spine and joint degenerative conditions, such as osteoarthritis of the knee, osteochondrosis of spine, and osteosporosis. And so in a group of patients receiving cartilax, these were the oral capsules, so imagine how much better the injectable would be. Along with standard therapy, significant improvements were observed. There was a reduction in pain, better mobility, a smoothing of pathological symptoms that were previously resistant to conventional treatment. And in fact, these patients achieved longer remissions and functional improvements compared to the control group, and the study was also noted that cartilax

17:56 was well tolerated with no side effects. And I think to make a brief aside and point, that's what's really cool about these by regulators is there's no site effects now. I'm not worried about side-effects of BPC 157. However, There are some people out there that may say, oh, it's going to do this. It's gonna do these bad things. That's what's cool about bioregulars because of the nature of how they work, virtually side effect free. In this case, maybe you have a little bit of an injection type reaction. I actually didn't notice any sort of burning or anything, and I've been injecting this a ton.

18:27 I wouldn't worry about any sort of side effects. I can't say it's guaranteed, but relative to other peptides because of the nature of how these chemically signal in the body, very, low risk, if any at all. So, Carlax has also been used in preventative fashion for older individuals at risk of joint degeneration. For example, elderly people took Carlex courses and reportedly had slower progression of spinal sclerotic changes. So again, these are not studied by the FDA, but we do have some of this from Russia. So many of the studies on cartilages have been published in peer-reviewed journals.

19:00 If you want to look it up, advances in gerontology, molecular biology reports, and International Journal of Molecular Sciences indicating that the research is obviously substantial. That's what's pretty cool about these, we have this. Ultimately, Cardalax shows noteworthy potential for promoting cartilage repair and healthy aging of connective tissue, but more rigorous research through our community is needed, and hopefully we can get this out there. So to just briefly touch on the side effects, I think this is absolutely one of the safest things you can do. But in clinical usage, cardalact has been well tolerated by patients with no side-effects, complications, or drug dependency.

19:33 There's also been no side effects or contraindications for cartilax. Again, showing it has very high safety margin. So when we talk about things like this, obviously we don't have data in pregnant or breastfeeding women, so I would probably steer away from there. But when were injecting, we just have the injection risk. I didn't notice any burning or any sort of welts or anything like that. that can come from peptides like GHK, but just make sure that you're adhering to sterile injection practices when you are experimenting on yourself.

20:05 So we look at long-term safety. Cardalax is quickly metabolized by the body's peptidases into amino acids, which means it doesn't accumulate or cause organ damage. And this is one of the advantages of short therapeutic peptide. They do their job and break down into harmless nutrients. Unlike many drugs, of which there are many to address cartilage issues. Cartilage is not metabolized by the liver into active or toxic metabolites. It's simply hydrolyzed by proteases. So very, very low risk and long-term safety-wise, there's not a lot we have to worry about. To get to the dosage as we are nearing the end of the presentation today, for preventative or joint maintenance, this would be athletes,

20:43 people that don't necessarily have any issues, but just kind of want to run a couple cycles. every year to make sure that they're doing everything they can to have the strongest cartilage possible. You do one milligram and I would just do this sub cue. If you wanted to do it into specific muscles, you definitely could. So for instance, if I was still playing football, I'd probably inject it in my shoulders and my neck because those are very high risk areas, probably my hamstrings too. But you can do subcure morning or evening, doesn't really matter. and you do this for 10 days and then just repeat it for every four to six months. So for therapeutic support, so again, if you have mild to moderate osteoarthritis or injury rehab, I would use two milligrams sub cure I am again depending

21:21 on the nature of where you're looking to have some benefit and do that for 20 days in a row. You'd need 40 milligrams or two bottles because we come in 20 milligram bottle. And you'd do every three to four months and also two for intensive or advanced so severe cartilage degeneration or post surgery. You do two milligrams once daily for 20 days, sub-Q or IM depending on where you want to do it. And the reason I say depending where I want you to it is if I have like for instance a bum shoulder, I'm probably going to inject shallow IM in that shoulder. But if i have overall systemic cartilage inflammation to where just my body is kind of creaky in general, i would do a sub Q into my belly.

21:57 For instance, like when I did my wrist, I just pinched the skin on my wrists right there, injected right into it. Boom. I was done and I didn't two milligrams. But in this case, for the intensive or advanced, you'd want to do it every day for 30 to 60 days and then repeat after six months if needed. You could probably do that within three months, but I'd just had that on there because you're doing a total dosage. And again, we don't want use 100 bottles in one month of this, But I think it's relatively safe. If you have soreness or just an injury or something around that that you're trying to heal that's kind of nagging, I would inject two milligrams per day

22:31 until you see resolution. Now, in my case, with my sore wrist, honestly, within 30 minutes, it felt better than the next day. I didn't feel anything. So I'm just going to use it as needed as a general maintenance thing. As I train and sometimes tweak stuff, you can use that way. And I even did a little math for you. If I have a 20 milligram bottle, I put two milliliters of water into it. One milligram is going to be 10 units on an insulin syringe, and two milligrams is gonna be 20 units. So that should be all you need to know. But just in conclusion, Cardalax is something that I think is pretty revolutionary in my personal experience.

23:06 Again, I can't say that you're gonna necessarily derive the benefit that i did. Just sharing what I know and what i know for myself. It has a dual role in promoting regeneration and curbing degeneration at the cellular level. because of the claim benefits in osteoarticular diseases and beyond. So while official medical use is currently limited really to Russia and obviously not going to be adopted into Western medicine anytime soon, it has a growing following in the longevity and biohacking community. The science so far, Hispanic cell studies to small clinical trials, mostly in Russia, provides a rationale for its use. I definitely think you can upregulate growth factors, reduce catabolic enzymes, and improve the functional state of cells on cartilage and other tissues.

23:42 and there's tons of people that have reported improvements and joint function and overall it has an excellent safety profile. So I think this is kind of a frontier. I plan to do more content about bioregular peptides that are injectable as some of the orals because they're pretty amazing for what we do. That is it for the slides. And that is everything you must know about Cardilax and how to use it. So hopefully that was helpful to you guys. I think I got everything on there that you would need to know to us it, but the cool thing about this too, in terms of cost, these are relatively cheap, especially relative to some of the other healing peptides out there.

24:17 If you want one that absolutely can help with either specific inflammation in an area that may be dealing with or even systemic inflammation, if you're dealing rheumatoid arthritis or osteoarthritis or osteoporosis or any sort of degenerative disease of that nature, I would absolutely throw in cartilax and use it. So it's pretty simple, but it also makes a lot of sense when you look at why there are certain therapies in the world that are not well covered. I think you could also use definitely alongside BPC-157, TB-500, GHK, and then maybe even exosomes and stem cells if you are into that kind of thing,

24:51 if party that way. But cartillax has been amazing for me so far. And I'm trying to get it into the hands of everyone I know. And what's cool about it, as far as I know, for competitive athletes, whereas BPC and TB 500 somehow are banned from athletes being able to use them, to my knowledge, and I can't put this in a legal framework or anything like that, Cardalox is not a banned substance, again, because it's just an arrangement of amino acids, which is pretty cool. So hopefully that was helpful to you guys. I would love to hear your feedback. And as you may watch this video and experiment with yourself, With some Cardalax, I would love to hear your feedback and kind of help get this information

25:26 out there, get it to other people, because I definitely think in relation to BPC-157, it can be something that you, when you're cycling off of Bpc, you use this instead. But in my experience, actually got much more benefit right away from this than I even did Bbc-137. Hopefully that was helpful. I love you guys so much. Again, I am so, so privileged and honored to get to do what I do every day, which is bring this material and content to you, guys. So I Love you Guys so Much. Thank you for all of the amazing and overwhelming support. And I continue to Get whatever form or fashion it is, even if it's just watching the videos, liking, commenting, subscribing,

25:58 or helping buy the products that we are working to bring to the world.