Peptide Q&A · February 2026

0:12 Hey everybody, this is Hunter Williams. I hope you're doing amazing wherever you might be in the world. Today is going to be the February, 2026 Q and A. Just before I get into this, first of all, I want to say thank you guys for submitting all of your questions. The link to submit a question to my Q&A videos is always in a description of the video called my little question box. You can always click that down in description. It's also in my footer of my email list. Also too, with censorship on the rise, please just make sure that you are on email list. That's the best place to stay in touch with me. I really just send out things that I'm working on and then also new video updates to update you on that email.

0:46 So make you're signed up for that so that can stay on touch. But I got some really good questions that i've picked out today. i'm gonna go through these, i'll try to keep this around an hour, maybe a little bit less. We'll see how it goes with the questions. But again, thank you guys so much. I am humbled and privileged to receive these questions from you, guys, because it makes my content better. And then hopefully it also answered your question. The theory I have behind this is that one person is asking a question, there's probably another five to 10,000 people out there that are thinking the exact

1:17 same question So these tend to do really well just when I look at the analytics and everything. So thank you guys. You help make my content the best. And without you, guys, I would not be here. Let's jump into it. I actually kind of group these by category today. The first one I'm going to go through is some joint pain and arthritis stuff. Is what peptide or stack best supports color support plus inflammation, plus pain when Chloe helps only a little. So I've actually started to see this a lot from people that they're using glow or Chloe and the The blend works, but it doesn't get them where they need

1:55 to be. And I think the one thing that you could add to this is cartilax. So I would add in cartillax at like one to two milligrams per day in addition to the clove. Then the other thing you can add there to help with localized IGF is a peptide called PEG-MGF or PEGMG. I'd add that in there in adition to cloblent. but you could also do a growth hormone peptide or growth on itself. That's one thing that a lot of people don't realize that they could be doing to help with that because it helps systemic IGF levels, whereas PGMGL is gonna help, with localized IGFL levels to helps with some pain in the knees.

2:30 This question specifically was about pain on the knee. That leads me to the next question, which is around rheumatoid arthritis. So it says, what peptide strategy best addresses systemic inflammation plus pain with multi-joint RA? Believe it or not, actually, the first thing that I would tell people to do is use a GLP. It's actually coming to light now that GLPs are really good at helping with chronic pain. That would be the 1st thing I'd do, is to use the GLPS. some of the systemic inflammation obviously like we just talked about the clove plus cartilax plus PEG MGF would also help with some the systematic inflammation

3:04 from rheumatoid arthritis but that is where I would actually look first because GLPs just seem to work make everything work better. What are my go-to peptides and supplements for stiffness and aches? I think that I keep in rotation would definitely be growth hormone or growth-hormone peptide that's going to really help a lot with that, then like I said, kind of a GLP is going be one of the ones that is also really powerful for that.

3:34 Next question around this was, do you need to fix the gut first before using KPV, BPC, TB, or can peptides help during the inflammation phase? Obviously, I think with anything, fixing the first obviously helps our gut health is integral to everything going on in our health overall. But do need fix it first, before adding in some of those? I would actually say that most of these are actually going to help with your gut. So if I was building a gut-health stack, I would actually use KPV, BPC, and TB.

4:04 Might not want to put GHK in there specifically for the gut. It's not going to hurt, of course, but I'd say that those would be the ones that I lean on. You could also use oral versions of all of those in addition to the injectable version to really help with gut health. And then also to microdose of a GLP. I think people kind of forget about some of the immune peptides when we talk about gut heath. So like thymusinophil-1, Thymalin, thymogen, those do really well. There's also another peptide that's an oral peptides people forget about that was actually originally developed to help with celiac disease.

4:34 And that is called lorazetide. So I'd actually throw that in there too. But when we look at autoimmune disease, rheumatoid arthritis, some of these ones where you have chronic pain, obviously fixing the gut helps, but I don't think it's something that you need to do like this whole gut protocol before. A lot of this is going to work in tandem. Let's move on to some mast cell histamine peptide reactions, because that is a question that I get asked a lot. I would actually say I'm working on a video right now, hopefully that's coming in the next week, where I have kind of a comprehensive stack to help with

5:06 mast cells reactions. But the first one is going to be, which peptides are most likely to trigger mast-cells and which calm them? I think the most like the ones is obviously going be the GH peptids. CJC and epimerelin, testimerelin, those are the ones that are most likely that I'd see to cause mast cell reactions. The other big one that seems to be happening a lot now is MOTC. So MotC, a lotta people are having mast-cell reactions to that. Outside of those, I'm sure there are some that do it, but those're the one's that see cause the most mast cells reactions,

5:36 and obviously they're some of the more popular used ones, right? Now, beyond KPV, because the question was, what can help calm mast cells beyond KPV? I think thymus and alpha-1 works really well to help call mast cell. Actually, GLPs help. So even a microdose of a GLP to the point where you're not necessarily getting appetite suppression, that you are not trying to use it for that, but you actually using to helped seems to modulate mast-cells. And then I would also say it's not a peptide, low dose naltrexone also works well for them.

6:06 That's the path I'd go down. if I was having mast cell reactions to my peptides. Next one, is using an antihistamine before injection a reasonable approach or masking a bigger issue? Well, it's definitely a reasonably approach to use antahistamines. You could use Benadryl before injecting, or if you're having that reaction right after, Benadyl typically will help. I would say it probably is masking, a big issue. which is that you are probably just in kind of a compromised immune state.

6:37 Now, genetically, we do see people that are more likely to experience mast cell reactions. Some people are just going to be more prone to have those. Fortunately for me, I'm not one of those people. I've rarely, if ever, had any mast cells reactions to peptides. But that doesn't mean that someone can't be pretty healthy and still experience a mast cell reaction. Sometimes it's just a genetic thing. But in terms of antihistamines, yeah, I think Benadryl before and after, if you feel like you are prone to that could be good. I Think using some of those other things I just talked about would be helpful as well.

7:11 This is starting to happen a lot with people. So the next question is around painful skin, sensitive skin on Reda, Matzi, IPA, SS 31 and GHK. I honestly don't know what is going on with the skin sensitivity. This has becoming more and more common to see people on reda. It seems like much more so than turzapotite have skin sensitive. If I had to guess one thing that we kind of leave out around GLPs is how powerful they are at inducing a healing state in the body.

7:41 And in doing so, this was actually something my father-in-law experienced. He was saying that he was kind of having like this tingling feeling in some areas of his body, and he's just using Retatrutide. It was also using TB 500, which I think could have probably exacerbated the tingle. Here's why. I for the first time, a lot of people, because they've been unhealthy for years. And again, that doesn't mean that you can't be healthy and have this, but I tend to see it in people that have typically been a little bit more unhealthy. They're actually getting blood flow and nerve repair to some areas of their body that they haven't had a good bloodflow for in a long time.

8:17 And in doing so, it is kind of causing the skin sensitivity or tingling feeling that they're getting. And so I know it can be painful to some people, but my best guess is that's what's actually going on. So I don't know. That's not a comprehensive answer. I think if anything, low dose naltrexone would probably help that and kind modulate that response that you're having. But I do think what's happening is that people are having like their nerve endings and nerve fibers fire on for the first time in a while. And that's what causing it. Again, it's something I've seen in my own family members.

8:50 Moving on to the category of GLPs, let's look at this one, which is around minor fat loss. So what is the best approach for the last five to 10 pounds without appetite suppression? Is microdose red at the move? I would say yes. You know, what's interesting is that when we look at micro-dosing red, a lot of people will poo poo micro dosing. They'll say, you know micro nosing is not worth it. It's kind of a waste of money. I actually would stay the opposite.

9:21 And for a of We've kind of had this wave with the GLPs take off and in that wave, a lot of people have thought that the appetite suppression is the main goal of the drug. Obviously it's a component of it, but they've really leaned into that. And I think that's not necessarily a bad thing. A lot people that deal with food addiction and some of those issues, I would say probably stand to benefit from that, However, it can get to a point where this appetite suppression is actually working against us.

9:53 And when we have appetite, suppression that ends up causing us to lose weight faster than we need to be, we're kind of inducing Basically like a starvation state in the body, and this is where people start to get really bad side effects from the GLPs. And so my best approach for those last five to 10 pounds is yes, a microdose of a GLP would work great. You could also throw in like some MOTC, some five amino, um, And you know, maybe some AOD if you wanted to, I think that would be the weaker.

10:24 out of those, but I would say you can definitely use a microdose of Reda for the last five to 10 pounds and you're really going to avoid the appetite suppression. And so I think that's a good thing is we actually want to use hunger as a signal to the body to tell us what's going on. Just because we have hunger doesn't mean that we need to keep upping the dose of a GLP. The next question is about staying on Reta long-term. Can someone stay on low dose RETA indefinitely for inflammation, food noise, and RECOMP into this tolerance build? I am becoming much more of the opinion that yes, you absolutely can do this.

10:58 And I think if you are staying Rета at a low-dose, which I would say probably is like under two milligrams, For the majority of the year, for all of that ancillary benefits, not necessarily for like the aggressive fat loss that would come at higher doses. I think you absolutely can. And maybe, like I said, stay on it 80 to 90% of year. Maybe you take one to two months off. From what I've seen so far, just from people I worked with and myself, I that's something that actually works really well because we're getting those ancellary benefit.

11:28 When we look at a smaller dose, obviously it takes much, much higher doses to get the tolerance build up. And so are we really getting the tolerances built up the smaller does probably a little bit, but I think for those ancillary benefits, they're still happening in the background. Even if we don't necessarily feel anything. So say I'm just taking one milligram of red a week and I don' really feel any thing from an appetite suppression or I m not like losing weight. I still think you're going to ge a lot of good benefits that are really good for longevity. And so that's kind of my approach as it stands right now. I'm sure that might change in the future, but that kind.

11:59 Of how I see in terms of staying on it long-term, a lot of people kind get fearful because they're like, well, if I go off of red, I I.m going to lose the appetite suppression that I've been getting. And I don't think you necessarily have to go. Off of it that much. If you're staying at a low dose, wouldn't stay on a high dose all the time throughout the year. But I think a load dose at least that. Kind of the conclusion I am coming to. What are some weird GLP side effects that people should know about like fatigue, chronic upset stomach, and what are the real dangers versus nuisance side-effects?

12:32 I think everyone is probably going to have a little bit of side affects regardless of what your dose is. I Think the biggest one that People have when they're first starting is the fatigue. And I noticed this when I cycle off and then I come back on to a GLP that I seem to be fatigued for the first few days. If you think about it, one, the body is obviously usually in an energy deficit, meaning that the GLPs are raising the amount of calories you burn and you're also probably taking in less because of the appetite suppression. And so that's going on and so you're kind of like adjusting to this new energy deficit.

13:04 And also to understand that because GLPs are so powerful at modulating healing, you are almost like inducing a healing state in the body, which what do we know? That causes fatigue. When the bodies says I'm going to repair, You are causing fatigue and that is the biggest one. In terms of the chronic upset stomach, I think people with relatively healthy gut microbiomes tend to do well. And so if you are nervous about some of the gastric upset, I would say probably do a gut cleanse before, and maybe that's using some BPC,

13:34 some KPV, uh, in some other things to help clean up the gut. Like I talked about the razzatide, but I think you will do better if you have less. The reason I say that is I've heard a lot of people get like really bad indigestion on a GLP. And I, think a lotta that comes from either Candida or SIBO or some things that they may be experiencing before they start the GLPs. They introduce the GLP, it slows gastric emptying, which then exacerbates those things. And so I do think it's best to have a cleaned up gut before.

14:07 I'm not saying you have to be a hundred percent clean, you know, and obviously we're using the glps to help clean up our gut too, but I think if someone's in a really bad place with their gut health, uh, It could be beneficial. And then what are the real dangers versus some of the nuisance effects? I would categorize those as nuisances effects. I think some these longer term ones where we're seeing where people are like chronically starving themselves, they're losing hair. They're actually probably having like some sort of neuroendocrine shutdown where their sex hormones are decreasing, their testosterone is decreasing. And again, I don't think that that's the drug. I think it's people starving themselves because of the drugs that are ending up in some of those issues.

14:41 And so those are the ones I see more long term that people are struggling with. That's very real. But I wouldn't necessarily put that on the other drug as much as I would put it on what the another drug is doing to change you. Those are byproducts of that. If you're hormonally optimized, if you are eating protein, exercising your resistance training, that's likely going to not be as much of an issue. Next question is, after stopping trisapatite, how do you address lingering bloat gas digestive issues a month after discontinuation?

15:15 I haven't heard this as much, but I would say ultimately this is probably going to go back to gut health. And I think when we look at gastric motility, obviously the GLP is slow gastrik emptying. So there's going be a little bit of slow down there. But I think probably what happens in cases like this is people might go back to eating more when they're off of the GOP, which causes some of that digestive issues. And so again, the foundational things are going to be very important for us to stick to when we talk about having digestive issue.

15:48 Obviously there's peptides that help with this. So I think VIP is really, really good. I would use like 100 micrograms of VIP. That can help the constipation, but it can also help cleaning up the microbiome and just also shifting the nervous system into a healthy state as well. There's so many benefits of the VIP, that's kind of how I'd look at that one. Here's a good one. Cold all the time after long-term weight loss on RETA. Is this common and what's the mechanism fix? Well, I wouldn't say it's super common. However, can speculate as to probably what is going on here.

16:18 And so for longterm, weight-loss for someone that's been on red, especially if they've lost a lot of weight, what tends to happen is there is a slowdown in the thyroid. Typically when I hear people that are really cold or they have dips in energy levels, The first kind of thought I have is like that person is probably experiencing some thyroid dysfunction. And so I would venture to guess if this person was saying this, their free T3 on their thyroid panel is, probably under three. I know most people feel better when that number is somewhere between four and five-ish in that range.

16:49 And so that would be my first thing. I would almost bet money that this is why they are cold all the time, because they lost weight, which is good, but then they also slowed down their thyroid. Because again, the thyroid is trying to adapt to the new energy demand of the body. You take someone that was overweight, that's overeating calories, and all of a sudden they lose under pounds. The body's trying maintain homeostasis with the energy, demand that it's experiencing. And that is probably what is going on. What combos are the best to reduce visceral fat?

17:19 Is it TURS, CAGR, TESSA, RETTA, especially in lipidemia? I think obviously Tessamerelin has the most evidence around reducing visceral fat. Reta also seems to be really powerful at reducing this real fat, specially around the liver. Seems to just basically annihilating liver fat I think as long as you have a GH peptide alongside your GLP, obviously the strongest of those would be testosterone and retitrutide or HGH itself and reditutide. I Think those will be the biggest things.

17:49 And I just think if you just have those right there and obviously your hormones are optimized, meaning testosterone everything, I'll think you'll be pretty good. Next one is do people have to take weight loss peptides forever? This is kind of similar to the other question. How do you transition often keep results? I kind have this idea and concept of blasting and cruising. And so for people that do need to lose weight, we would kind build up into a blast phase where we are using more of the peptide. Then when we get to weight we want to be at, We would cruise down to a very low dose, which would be the micro dose.

18:20 really sustain a microdose for around eight to nine months out of the year, take one to two months off here or there and be in a really good place. And so that would be kind of my thing, but it's one of those things, the GLPs are so powerful at what we're seeing they do for metabolic health, even for healthy people. I don't think it was one those that I would afraid about quote unquote being on it forever. It's just one thing you want to be conscious about how you're dosing it. You don' want be on eight milligrams a week forever is what I'd say. If RETA becomes unavailable, what are the best replacements for glucose management?

18:52 And what about Masdutide, Servodutides plus Trisapatite? I don't really see us not being able to get Reta. If you're kind of sharp, you probably know that the takedown of Rete, maybe from some of the bigger players would have been an issue, but it's still relatively easy to source. And that's why I have people in a private group and I'll have to people on my email list. I would say that if it was something, sure, cervidutide and mazutite look great. Those are basically a GLP plus a glucagon agonist, so they don't use the GIP receptor.

19:26 But if you paired those with their zapatide, hey, guess what you're doing now? You're now using a GLP, G-I-P, and glucogon aganist. And so yeah, those could absolutely be a replacement. I think you would get pretty similar results to what you wood from those if you were using Reda. But again, I'm not someone to fear monger. And if Redis seems like it's becoming unavailable as of this filming in February, it doesn't seem like is going to be too hard to get going forward. If you are a little bit more skilled at purchasing from discrete sources.

19:58 Let's get into some questions around labs and overall health markers. Thought this was interesting. What peptide stack would support liver health when AST and ALT are turning the wrong way? I think the first thing is going to be glutathione. So if things are going bad for your liver, glutothione can do wonders for that. Also, another supplement called Tudka does well. Another supplement in acetylcysteine, otherwise known as NAC, does really well, You could also use some of the bioregulators.

20:28 So, Ovagen and Liveragen are two peptide biiregulators that help with the liver. Should I do, you know, one milligram a day to two milligrams a days of both of those, and those should help bring things back into balance. And also, too, Rhetatrutide, really powerful at reducing liver fat. I think that would only be beneficial, especially if you're using it as a microdose. been taking peptides that cause very high liver enzymes. How do you interpret that? And what would you stop and keep check? Um, I mean, typically most peptids are not going to like really raise liver, but depending on the ones that you do, if they are making you work out harder,

21:05 that could elevate liver. And so some peptide really can help people go into an anabolic phase where they're putting on muscle and that's what you're doing. That's true. Using them for, uh, do think that, you might experience some transient rays in your liver enzymes to which you could address it with some of those things we were just talking about. Who should not take peptides and what should be avoided? I think that's kind of, it's kinda a hard question to answer, like who should NOT take peptides.

21:36 I do, I would say someone that probably is like actively diagnosed with cancer, would probably stay away from the angiogenesis peptide like BPC and TB. Would probably say away form the growth hormone peptids, but some of the immune peptidies could actually be very, very beneficial. GLPs, i think, could be beneficial in that case. That's really the only thing that I could think of where you'd say like, hey, don't use peptidae in the case, Which leads me to the next question, which is, do peptides cause cancer or only accelerate existing cancer? What are your rules of thumb?

22:06 I kind of go back to like, I think if you were injecting directly into a tumor, some BPC or TB 500, that might not be the best thing, but I don't really see peptide, at least in the context that we use them, causing cancer. That's also though, you know, I don't want people to be afraid, but that's why we cycle them. And so would you use BPC all year? I personally wouldn't. I think cancer would be still very, very low risk if you were chronically on BBC all the time for decades on end. Would that put you in a cancer-favoring environment?

22:37 I don't think so, but we don' really know. And so I'm more of the opinion that yes, they could potentially accelerate existing cancer. But I think when you look at cancer, a lot of cancer goes back to metabolic disease. Not all, But a lots of cancers goes to back metabolic diseases. If we're using a of these peptides to help metabolic health, I thinks it's going to create an environment in the body that's much more favorable to not have cancer Moving along, let's talk about some of the growth hormone peptides. This is a pretty common one I get, but I thought it'd be good to address.

23:09 Again, what are the pros and cons of secretagogues versus HGH for men over 40? Well, I would say men are always going to do better on HTH. I think younger people respond better to the peptides than older people do. And I there's an age, it's going to be different for everyone. Maybe it is 40, maybe it 45, may be it 50, to which you will notice dramatic improvement, even off a little dose like 1 to 2 I use of HGH over the peptides. Now, that doesn't mean if you're 65, you can't stand the benefit from taking a GH peptide.

23:43 Obviously, You can, but I thinks it one of those things When we're relying on this feedback loop in the body that relies on the pituitary and the liver to turn the peptides or basically use the peptides to increase endogenous HGH, as the buddy gets older, it's just not going to work as well as if we were like 25 or even 30 or 35. And so I would say I use HTH and I'm in my thirties, but for someone that is like in their fifties or over 40, I think you're just going respond better to HGH and hey, you can go back and forth between the two.

24:14 After an eight-week tessamerelin cycle, do you go right into another sacretogog or take a four to eight week break? It kind of depends on where you want to be. I think if you were to go from tessemereline to HDH, I'd think you could absolutely just go for tesemere line to HGH. Could you go from testamerelin to ipamerelin? I think that would be good because testamerelin is a growth hormone-releasing hormone, whereas ipamelin is growth-hormone- releasing peptide. And so you're really increasing growth hormones naturally via two different pathways, which I would do really well.

24:48 But if you went from Tessamerelin to CJC, is it going to do as good? I mean, it's better than staying on Tesseramerelin probably for another eight weeks, but I like to think of it as like, okay, we have the GHRHs, which are Tessemerellin, Serumerellan, CJc. We have GHRPs which is really Ipameralin. And then you could use MK777 would be the other one I use. I think you could definitely go back and forth between those and really throughout the year have GH peptides that you're using without really having to worry about too bad of a tolerance buildup because you are kind of alternating the pathways.

25:18 That's just my thought. I know people stay on Testimonellin for a year and they do fine and that's good for them. But I if you were going back-and-forth, just think of it as we've got the GHRHs on one side, GHRPs, on the other side and we can alternate back & forth with those. still maintain relatively good receptor sensitivity to them because we're alternating the pathways and obviously too you can always throw in HGH in there. Can you stack HGH in the morning plus TESA and IPA in a PM?

25:48 Is this redundant or synergistic? I think it's synergic. I mean, if you did that one specifically, you're probably going to notice a huge increase in growth hormone. So you might get a little bloated. Tessameralin and nipralin alone are enough to really, really increase growth hormones. You probably will notice more water retention, but if we're going through a muscle building phase, that can be a good thing. I've done this plenty of times in the past. If I'm doing it, I think the Tessa and Ipa is better at night because that's pulsing the pituitary. So it's a little bit more natural to do that. And then we're adding the exogenous HGH in morning to kind of accelerate fat loss or body re-comp.

26:23 You definitely can do. I have done that in past, but I don't think it is necessarily redundant. Just wouldn't do it all the time. Maybe do for eight weeks, one to two times a year where you're combining those and you'll be good. Speaking of HGH, can you run two IUs of HEH continuously five days on, two days off, or does HHH need cycling? What on-off cadence? I don't cycle HCH really. If I'm cycling it, I just going back to a peptide. I think again, because it's a bioidentical hormone, we don't really need to cycle it.

26:56 We don' have the same antibody buildup or tolerance build up that we have for the peptides. So I think if you're doing it five days on, two days off, you are totally fine. And I don''t really see any benefit to coming off of it, especially a low dose. Now, if your running higher doses, like into the six to eight IU range for whatever reason, whatever goal you have, yeah, would you want to come off that or like blast and cruise the HGH? Of course, but I dont really any reason again, because I I almost view that as lumped in with my HRT, with testosterone, my thyroid and everything there.

27:28 Side effects of Tessa causing water retention, restless legs, carpal tunnel, and arms falling asleep. Is the dose too high or do you switch agents? I would just say the doses too. And maybe the dosage is only one milligram. They didn't say that dose. Maybe it's two milligrams. You can cut it down to one. If it was one, you can get it to 0.5 milligrams, but yeah, if you're experiencing those things, that is basically from super high levels of growth hormone, which you would get again, If you were taking like six to eight, I use of HGH. All right, moving on to some logistics questions around peptides, around shelf life and storage.

28:03 So how long are LaFly's vials good un-reconstituted? How long after backwater do all need refrigeration? I think if you're being super cautious, you could refrigerate everything. Un-reconstitutated and reconstitutive peptide, if want to keep them refrigerated. I keep tons of my un reconstituited peptids just in a cold, dark room at room temperature, and they do perfectly fine. And that case, those unreconstituted ones are going to be good, I would say for at least two years, probably longer. I've used ones that are much older than two and they've done fine.

28:33 And then after backwater kind of depends on the peptide, obviously like a 30-day window, it's going be the highest efficacy. After that, it does start to decline, but again, I've used peptides that are six months, 12 months old, and I still get the effects from. Now, is it 100% of the effect? Probably not, But I think, you know, the good rule of thumb for being in the fridge is usually after three months you're probably going to have to increase the amount you are taking to get to the same effect as it would if it was in first day. But again that can be dependent on peptide and what peptid it is.

29:07 Can you inject Tessa and IPA in the same syringe or keep separate? Yeah, you can definitely inject tessamerelin and ipamerelin in same Syringe. I wouldn't put anything in there like BPC, or I would put a GLP in their, I like to think of those, obviously there's like infinite combos of different peptides. Like to those as the ones that I inject in, the syringes, do they hit the pathway? And if that's the case, is that working well? So I, would keep Tessanipa completely fine in that syrange. If you get persistent lumps, what to do beside massage and fascial tissue rolling with, you know, lacrosse ball, um, You know you could try to rotate injection sites.

29:45 And so if you are experiencing lumps like if doing them in your belly, try going in the thigh, Try going into the arm, other areas that you can do a subcutaneous injection. and typically that tends to go away. There's also some really good cream products. So you could get like a KPV cream. You could a glutathione cream, there's people that have those now. And I think that does help get rid of some of those bumps. Um, There is also a product called Bioregenics that I really, really like.

30:15 It's an amazing cream I use it basically every day and I'll put that, you know, around my testosterone injections or around belly where I do my Peptide injections and that seems to work really, really well. So not shilling for a product, but I do love that product. All right, let's talk about some more ancillary peptides. Os01, what is it and how you use it. This is also known as ATX304. I really like this. It's basically an AMPK activator and what it does activates AMP and the process of doing so kind of improves everything in the body.

30:50 When you think about AMP activation, it kindof exists more on this autophagy spectrum. So it's working to basically extend longevity, create autofagie, created almost like a fasting like state in a body and in doing, so helps us lose weight. it improves blood work. So I really like it. It's just that I've noticed to see the effects, you really want to go up to like 500 milligrams or so on it, the human trials that they used ATX 304, I think they were doing 1000 milligrams a day. And the good thing about that is they had no downside whatsoever. They only saw benefit, fat loss, better blood work, and better cholesterol and everything.

31:23 So it's one of those ones that right now is kind of cost prohibitive. to use if you're doing the doses that actually create the effect. The only thing I would say with that is just don't use it around around weight training sessions. I noticed that kind of felt weaker in training session that I either took it before or right after. So I think it's similar to Metformin in that sense, I'd probably use away from my weight-training. Think it is fine to used before cardio, but I'll just give it a few hours. Don't used it in the few hour before and after a weight train session.

31:53 BAM15, how would you use it effectively for fat loss cycling fastest versus fed? Can it stack with Carterine? I think it'd definitely stack it with Carterine. It wouldn't be my first choice, but it does work well. And so if I were going to use, it I would start with like 50 milligrams a day, and then the higher end of the range would probably be 200 to 250 milligrams per day. And so I would start there, kind of work your way up, but it would definitely be something I use in like a six to eight week cycle, and I'd cycle off for at least that long. I don't see any problem using it with carterine, But it does work well. Again, it's just a little bit more expensive and relative to the cost of GLPs, I think you're going to get more bang for your buck with the GLP's.

32:29 Talked about a little bit of this a few minutes ago, but AOD 9604, does it actually work and for who? It does work. I would say it doesn't work in isolation. So I'd say for someone who's on a GLP plus a GH peptide plus some mitochondrial peptides, you can throw in Aod and probably get like an extra 5 to 10% benefit from it. But outside of that, I don't really see it doing anything. I have noticed it tends to work well for water retention. So if you're taking Tessamerelin, an Ipameralin or a GH peptide, and you feel like you are getting water attention, AOD seems to works well.

33:02 For water retentions, I like it in that case. But again, it would be one of those that's nice to have. And if your budget conscious, It would like the last one I would get out of all those ones that I mentioned. What is the best sub-q dosage of five amino? This is kind of all over the place right now. You have some people saying you should inject 50 milligrams of 5-amino. I feel really, really good when I inject one milligram of Five-Amino, I've gone to two milligrams does seem to be a little bit stronger. After two-milligrams I get way too jittery, little too anxious and almost kind this feeling of mitochondria overspend.

33:34 And so I think it's kind one of those ones, yes, you will feel it. But I think if you get to the point where you're relying on it for energy, the dose is probably too high. And again, if your doing that for too long, I you probably will have some of this mitochondria overspent, at least from what I've seen from people. So again I like that one milligram a day. Some people even do well at half a milligram. But hey, if you want to inject 10 milligrams, knock yourself out. I'm not here to tell people not to do that. It's just for me, when I've done that, it seems to be too much.

34:04 And I know the oral dosing is anywhere between 50 to 150 milligrams per day, which is fine. But again, people are saying, well, that's the world dosin, I can take 25 milligrams a day. Hey, If you wanna do, not saying not too, but just be careful. Can raise your heart rate, can kind of make you a little too jittery and not feeling good. So just always start low and go slow and then you can to go from there. My take on PE 2228. I really like PE2228, it seems to be very similar just in terms of how I respond to it as P21, but basically it is one of those peptides.

34:41 It's not necessarily a neutropic, But it definitely works on brain health, modulating inflammation in the brain, helping with neurotransmitter balance. The dose I used was like 250 micrograms. And that seemed to be kind of the sweet spot for me. You might not feel anything of that dose. I felt something. So you could probably go up to like 500 micro grams. But I like it. It's very similar to P 21. Um, you're not going to necessarily get the nootropic effect out of it, I think for all the people that want to use cerebral. for just kind of like a preventative thing for brain health, I don't know that you always need to use cerebral liason to do that.

35:17 I think cerebral liaison is like the strongest thing that we have and you can use it for sure. But I Don't think a lot of people need resort to that, um, you could probably save that and save your money for a more acute issue. Um, don' think there's anything wrong with taking it, but I would just kinda use P 22 28 or P 21. If I'm not necessarily worried about like a big issue, I would say if cerebral isom for those bigger issues. Around cerebral isin, how would you use it, reconstitute, and a basic protocol? I will say there is this product circulating right now, which is like lyophilized cerebralisin.

35:52 So it doesn't come in the ampoules. I think the best dose of that is around 20 to 30 milligrams per day. You'll usually see this in like a 60 milligram lyophyllized vial to which you could use 20 milligrams of per that day and do like, a month of five days on, two days off. And I you'll notice really good benefits from that if you just want kind of, that cognitive edge. Obviously then we have the cerebral liason that comes in vials to which you could do one ml per day, you can do five ml's per, day you do 10 ml, 10 mls per. I think for a maintenance or kind of just like a preventative protocol, one ml per-day of the pre-mixed cerebral liaison does well.

36:26 And you. Do that for like 30 days. Um, if you go to cerebralliason.com, You can actually click on the prescribing information and actually look at the prescribed dosages for the certain events on there. And on there, you're going to notice that all the prescribed reasons are stroke, TBI, brain injury, things of that nature, or excuse me, Parkinson's or Alzheimer's. And so I think for some of those acute issues, yeah, definitely do the higher dose. But I Think for people, uh, it seems to be really, really popular right now. People wanting to get their hands on cerebral isin.

36:57 So that's kind of what I would do. Methylene blue, can you stack it with C-max link P-21 daily or use cycling? I probably wouldn't because I think it, methylene blue is an MAOI inhibitor. And so I could probably interact with some of those things, at least in a way that I personally wouldn' t want to do. So you probably could, I just wouldn t do that. I would keep it separately from all those other nootropic peptides, and then I'd definitely cycle it if you're going to use it.

37:29 Bioregulators, oral versus injectable. What's different? When is oral enough and can they be stacked with peptides? They definitely can be stack with peptides. Absolutely. I would say that oral are going to be much more mild and kind of have a systemic long-term, probably positive effect, but you might not feel them. Whereas to me, the injectible bioregunators seem to go really far in terms of how they feel. Some of them you won't feel if you don't necessarily have an issue. But I think a lot of then can used really well, you know, cartilax, Vessagen, Velon, Prostomax, some of these work really well.

38:03 Vestigen versus Ventfort, which for vascular health, and should you wait months between them? No, I think you could actually use them together. I Think depending on what your goal is. And so with vestigen and Ventford, those work on the blood vessels, Which is just going to kind of make you healthier overall. You definitely use both together to enhance the response you would get. So when we do look at these, if you are using the injectable and the oral ones that are analogous to each other, you just can use it for the cycle that you're using them and get a really good response.

38:36 Alright, let's talk about some hormone questions. The first one is a really popular one probably doesn't get enough attention is high SHBG. One of the causes why it matters and what interventions you like so. I think highest HBG it, well, it can come from a ton of different things. I would say most often people with highest BG is because they have high amounts of body fat or high amount of visceral body, fat. And so losing weight is obviously the first intervention.

39:06 So, assuming that you are a very healthy body fat percentage, I would say, again, it can come from a lot of toxic exposure, is one of the main things that I see. But to bring it down, boron works really well, zinc works well. And then the sledgehammer approach would be to take something like a proviron, which would help bring down as well and so, almost in all cases, proviren will help lower SHBG which will raise your free testosterone and that's what I'd do.

39:38 scrotal cream testosterone or scrotal testosterone cream, why it's hit or miss and guidance for rapid aromatizers. I personally don't use the cream anymore for this reason. One, because if you aromatize it or deplete it wrap or burn through testosterone rapidly, you really have to apply like two to three times per day, which is kind of inconvenient if we're all being honest and we are working people. But it's also, too, the absorption can be variable. So some people just have better skin that absorbs things like cream.

40:09 I tended to not absorb that well. Also, depending on how much you sweat, even if you're letting it dry out, if have 15 minutes where you are letting dry, you can still sweat some of it off. And so I think it's just much more variable because there's much variability that goes into how it is absorbed. And then also too, some people excrete it faster. So if you're excreting it too fast, what I noticed is that my estrogen levels were never high enough to feel good because I was burning through the testosterone so fast. It didn't have a chance to hang around and saturate the receptors as well.

40:40 But that being said, some guys do really well on cream, but that's why I just, as many times as I've gone to cream and gone back and forth between cream injections, I have always gone and stayed with injections. For testosterone frequency for an older male, how to manage high E2 without an AI and his cream or test prop better for some? Well, definitely can be better. For some, I think first question is, is the E two really high or is it high compared to lab range, which is based on the lab.

41:13 Range of men with low testosterone. Thus they typically will have lower extra dial because their testosterone is low. So a lot of guys, they're estrogen 60 and they think, oh my goodness, this is a disaster and an emergency. And that's not the case at all. I feel perfectly healthy when my estrogen is like in the seventies or eighties. So I'd feel really good when that is the cases. Not saying everyone's going to be like that. But if we were to look at that, okay, if I'm going answer the question, what would it be? Obviously being healthy body fat is going help. Most guys just aromatize more because they have more bodyfat.

41:44 If you lose weight, that does as well. I've actually seen GLPs, I haven't really heard people on GLP's complain that they're aromatizing too much. So I think GLPS work. I also think metformin works really well to help metforming kind of acts like a pseudo aromatase inhibitor. And so if you're going to take an aroma taste inhibiter, why not take met formin? Because it's kind to kind do the same thing, but it typically going make you a little bit healthier, whereas the aromas taste and inhibitors make more sick. And so that would be my suggestion in terms of dealing with high E2.

42:14 Although I think most people that say they have a high e2 is not always high. What do you think about Kaiser Trek? So I think Kaiser Treks is better than nothing, but it's not as good as injections. And so people kind of get mad when I've said that Kaiser treks isn't great. I don't think it is that much better in Clomophene, to be honest. If you look at what guys' levels get to, I thinks it pretty similar to Clamophane or in-Clomaphene. Would I rather be on Kaiser trek than in clomphene? Yes, long-term, absolutely.

42:46 But it's just not going to be good as injection. So, hey, it is better than nothing, but I don't think you're really going get the full effects of the testosterone. That's what I would say. After starting testosterone, how do you manage hormonal acne? I think the best way to do this is the injection frequency. And so if you're doing smaller doses more frequently, that tends to help with the acne, although some guys still just get it. One trick I have learned is that actually Ivermectin horse paste does really well.

43:18 So I always keep some of that on hand if my back breaks out or my shoulders break out, and that typically will help the acne go away really fast. Also, one thing I've been playing around to recently was KPV cream, and that seems to work really well too. I really like that. But that's the best answer. That's for me, because I have dealt with hormonal acne on testosterone. It was interesting the first few years, I didn't. And it just seems lately, you know, kind of had that on and off. The ivermectin horse pace has worked really Question near and dear to my heart here, for kids playing football, what are some of the best strategies to

43:57 reduce concussion risk? Any peptide options worth discussing? I think for a kid, you know, this is going to be something that you decide to do, but I do think that BPC and TB 500 will work wonders, especially for kid playing ball. I wish I had that as a high school or college athlete playing because it would have helped. It's not really going reduce their concussions risk because you're going concussions anyway if you play football. But that would be what I go to.

44:27 Ehlers Danlos, that seems to be something that is becoming more and more common. Now I'm hearing people, which seems, I think it's like a connective tissue disorder. What are some peptide options for it? This person asked if ARA 290. I would have ARI 2 90. Ehlers-Danlos, that's probably what I would go to.

45:06 Tonitis, any peptide options worth exploring for tonitis? I've heard, again, I don't really know. I haven't done a lot of research around this. People say BPC and TB 500 work really well for Tonitus. Again, if it's one of those things that is stemming from inflammation, it would make sense that those work. I think BPC, TB 500, SS 31 would probably be the first ones that I would go to and then see from there. But yeah, it's one of those things I've had, I wouldn't say tinnitus, but like ringing on and off in my ears, probably from concussions when I was younger.

45:37 And I do think all of them helped. Hair thinning and shedding, are there any peptide options in the usual non-peptide basics? You check, obviously GHK. There's actually another peptid called AHK, A as in Apple, HKCU, and that seems to be better for hair loss. How you would apply that, it's kind of up to you. You could get it in a liofilized vial, you could probably inject it and be fine at the same dose that you with GHk, so like one milligram. you can also mix it, then drip it onto a micro needle pin, And then do that on the spots that want to regrow hair, I think that would be a good idea.

46:11 It doesn't have to be too complicated. Again, you just mix it with backwater and then put a little drop of the mixed solution on a microneedle and roll it on those areas. And it probably would help. So that's what I would do is get the AHK CEU and try that first. Is there any real peptide angle for hair color restoration? I mean, for me, GHK works really well to make my hair darker. Every time I take GH K, it makes my head more black, like especially my beard. Um, and so again, I think that it's just going to kind of a different for everyone.

46:42 Plaque psoriasis, peptide strategies that make sense. I think when we look at psoriasis, I would look all the immune peptides, so like thymus and alpha 1, thimogen, thymalin, KPV, even a little bit of LO37 I'd think would do well. And I also look the ivermectin horse pace, that would also do for people too. For psoriaasis I've seen that helping there. So kind of treat inflammation at the root. BPC and TB 500 could actually probably be helpful too, probably even GLP as well, Snap eight, how do you use it topically mixing the serum dosing frequency

47:13 and thoughts on microneedling use? Yeah, I think if you wanted to microneedle it, you could definitely do what I said. So just mix it with backwater and then drip that onto a miconeadle and roll it. I don't really know the best way to mix that into a serum. Actually probably do some research on that. You definitely could. If you want it to like mix with the back water and put it into hyaluronic acid, You could probably get it in to a Serum. Taylor would know much more about that than I would. Let's see, getting close to the end here.

47:45 Post hip replacement plus low hemoglobin hematocrit, try to support red blood cell production and interaction with TRT. I think Vessagen and Ventfort would work really well with that. Obviously, if you had a hip replacements, probably some anti-inflammatory peptides like BPC and TB 500 will work well. That's going to help with blood flow too. And probably, some cartilax, I would say around there just to Getting closer to the end here. Do drug tests detect peptides? I would say probably not, but I wouldn't bet my career on it, if that makes sense.

48:18 And so as far as I understand from chemists I talked to, one, peptide are in and out of your system pretty fast. Two, it's really hard to detect a peptid in a urine. But they may be working on things now where they can test metabolites of certain peptides. So they wouldn't be testing for the peptide, but they would notice a metabolite of the peptide that would be over a certain threshold to which they within say, okay, we think you might be taking a peptid based on that. And so this person was asking about a natural bodybuilding show, um, which kind of sucks. You know, I did a national body building show one time. I obviously didn't use any peptids for it, they consider that when peptoids a lot of times are natural as natural, as any other supplement.

48:54 They just happen to be an injection form, thus they're not natural. Uh, which is kind of ironic, but anyway, um, short answer, probably not, But it's also one of those things. I don't know the testing methodology, so definitely don' don''t take my word on that one. How do you physically organize peptide vials? I have a lot of my peptides in pins. And then I also just have like a little, like little mini crate in my fridge. If I had vial ones, uh, that I just kind of organize them categorically. So, super easy to do.

49:25 What is the difference between pharma and compounded GLPs versus research grade? Can research-grade be more potent and could compounding be mislabeled? Yeah, all of the above. Compounding can definitely be misslable or not as potent. Ironically, like some compound places, I'm not saying anyone in specific. anyone specifically, but sometimes those are not as clean as even some of the facilities that research peptides are made in. And so research can definitely be, I think, more potent depending on how it's manufactured compared to compounded, depending upon how its manufactured. So it is really variable. There is no straight answer on that.

49:56 I do think in the research world you will see some places that maybe overfill slightly. Maybe you get like an extra one milligram or so in a vial sometimes. That is just going to happen. You are going have variants just like when bags of chips are Some of the bags of chips that have more and some of them that Have less and so again, it's just variable in there But if you're buying from a reputable research person or company, I think you'll probably be in a good place And the last one is, can you use insulin pens for peptides, pros and cons?

50:27 Yes, you can. I actually, like I said, just said do that myself. You just have to buy the empty pens. you buy them empty cartridges. It's kind of annoying to have two set up, but then you're good, for however long it's going to last, whether it was 30 or 60 days. And so yes, it is much, much more convenient. But depending on like what peptide you have, you might need like, five to 10 different pins because you may be using five or 10 things. And so I would say you can. It's a little bit more cumbersome. I do have a video about that in my Dropbox folder. You can look up, but you absolutely can't.

50:58 And that was the last question. So thank you guys so much. I finally got caught up on all the questions I've been behind for a while, but went through and handpicked some of those. Thank you, guys, so, much for submitting those questions. Again, just in closing, without you I don't exist. The support I get from you whether that's using my code of places, it's, you know, liking, subscribing, commenting, sharing with friends and family. I can't tell you how far that goes in supporting me to help bring you these messages.

51:28 So again, my heart overflows with gratitude every day that I get to do this. Thank you guys so much. Again, just make sure on the email list, as always, you can hop over to my private group if you want to Live calls, we do live group calls every Thursday night at 8 p.m. Eastern. You can hop on and ask me questions there and then obviously you can DM and private message me inside the group anytime. So thank you guys so much. Again, I just always want you to know you are appreciated, you're loved, and I will see you in the next one. Peace.