Peptide Q&A · January 2026
This is the January 2026 Q&A. I pulled questions from the submission link in my video descriptions and email footer. I had 30 pages to work with and got through about an hour of them. Here's what we covered.
VIP for pain
I don't recall specific research on this off the top of my head. But VIP is great at calming a stressed nervous system, and that alone can help with chronic pain. Start around 100 micrograms per day. VIP is one of the most versatile peptides out there, so I recommend most people use it.
Peripheral nerve injury from a stingray sting
For nerve damage, oral options are limited. You could try oral bioregulators, but injectable ARA-290 is going to be your best bet. I'd say around four milligrams a day.
Sermorelin vs CJC/Ipamorelin (50-year-old female)
If Tesamorelin gave you joint pain, I'd actually skip Sermorelin and go to CJC-1295 no DAC with Ipamorelin. They're both GHRHs (CJC and Sermorelin), so similar pathway. If you want to do Sermorelin anyway, 200 to 400 micrograms is the dose for most people.
Welts at injection site with Glow
Yes, this is normal. You're not allergic. GHK does this to a lot of people no matter where you inject. It's one of those things you kind of have to deal with if you want the benefits.
5-Amino-1MQ timing
You can take it two hours before a meal, but it's fat-soluble, so taking it with food works well too. I switched to the injectable version because I tolerate it much better.
HGH cycling for a 62-year-old female
I'd just stay on it. Five days on, two days off works fine. I don't really cycle HGH at low doses. No real downside to running it year-round.
Stacking Reta with muscle-preserving peptides on TRT
First, dispel the idea that you can't stay on a GLP-1 long term. They're great for longevity. You don't need a high dose forever, but a maintenance dose is fine.
If you're on testosterone, start Reta at 2mg per week and titrate up. Add a growth hormone peptide or low-dose growth hormone (2 IU) alongside it. I love stacking GH peptides with Reta because it makes muscle maintenance easier in a calorie deficit.
Why cycle peptides
The body builds anti-drug antibodies (ADA) against peptides. The immune system sees them as foreign and builds tolerance. You either escalate the dose to get the same effect, or cycle off. Eight weeks on, then four to twelve weeks off is a reasonable framework.
Some peptides stop working entirely if you stay on too long. Some people say you don't need to cycle. Based on what I've seen in literature and practice, cycling is best practice.
Glow with glutathione
Yes, you can stack them. Just don't put them in the same syringe. Glutathione will mess with the GHK.
Best peptide for working at a computer all day
The body isn't designed to sit at a screen all day. Take walks, use a treadmill desk, minimize screen exposure when you can.
For nootropic peptides, Cmax, Selank, P21, Nupept, and Dihexa all work. Nupept and Dihexa are the brute-force options for focus. Just don't use peptides to turn yourself into a robot.
Lowering cholesterol without a statin
Reta would be my first pick. There's evidence around MOTS-c lowering cholesterol, and SS-31 helps through mitochondrial improvement. PCSK9 inhibitors have compelling data too.
Some people just genetically run higher LDL. If inflammation and metabolic markers are good, cholesterol becomes much less relevant in the heart disease conversation. An SGLT2 inhibitor like Jardiance has helped my numbers too.
Reta fatigue
Don't get FOMO if Tirzepatide works great for you. Tirzepatide is amazing. People achieve incredible results on it.
The fatigue on Reta usually goes away after two or three weeks once your body acclimates. Reta induces a deeper calorie deficit than Tirzepatide, so you'll be more tired. Push through a few weeks if you can. MOTS-c or SS-31 will help with energy more than NAD+ in this case.
BPC for ulcers, eight-week mark
Don't cycle off just because eight weeks is up. With injuries or gut issues, stay on the peptide until you're healed. Better to up the dose if needed than come off too early.
You also have options like KPV, VIP, and larazotide for gut healing. You could run BPC for eight weeks, then bring in KPV and VIP.
Autoimmune peptide stacks
Most autoimmune disease comes from chronic stress, mitochondrial dysfunction, and poor gut health. You don't have to be overweight to have poor gut health. Glyphosate damage to the gut lining causes leaky gut and toxins in the bloodstream.
Start with VIP. Add Thymosin Alpha-1, Thymalin, and KPV. Larazotide is good. LL-37 is okay, but it can backfire on autoimmune patients, so wait until you're cleaner before using it.
Allergies and asthma
Thymosin Alpha-1 is my first pick. VIP works well for asthma because of the lung effects. You can also try lung bioregulators like Bronchogen or Chonluten.
When NOT to take TRT and peptides
If you're a guy trying to get pregnant in the next two years, TRT might not be the move. There are ways to maintain fertility on TRT, but it's simpler to wait, have your kids, then start.
For peptides, I'd be careful with growth-promoting peptides if there are active tumors. That's about it. Outside of that, optimizing the body is almost always good.
BioAMP (ATX-304) protocols
I don't take BioAMP around strength training. It's an AMPK activator, more on the autophagy side than the anabolism side. Similar territory to metformin, maybe a touch of mTOR inhibition like rapamycin.
It's great for fasted cardio. Just don't take it within four hours of strength training. It made me feel weaker in the gym during that window. Take it morning if you train evening, evening if you train morning.
Stacking CJC, Ipamorelin, and Tesamorelin
I wouldn't. CJC and Tesamorelin are both GHRHs, so the pathway is redundant. I tried that years ago and got a lot of water retention. Use CJC with Ipamorelin, OR Tesamorelin with Ipamorelin. The Ipamorelin (a GHRP) is the complement.
Cardarine (GW-501516)
Still in my stack. I also use GW-0742, which I think is a touch stronger. Same dose, 10mg. Cycle on and off given the mixed cancer data.
GLP-2 (and Tirzepatide for gut healing)
Tirzepatide microdosing works amazing for gut healing. That's one of the real benefits of microdosing for autoimmune, leaky gut, or irregularity. Higher doses can backfire on the gut. Start low.
Stacking Tirzepatide and Reta
I've done this. One milligram of each is what I've used. Treat the total milligram amount as your total GLP load.
What it does is offset the glucagon-driven appetite from Reta with the appetite suppression from Tirzepatide's GLP/GIP balance. You still get the metabolic benefits of Reta with less hunger. Solid option for people who get too hungry on Reta alone.
Betaine HCL
Great supplement. I keep it in my pantry for indigestion or heartburn, or before a cheat meal to help break down food I'm not used to. Pepsin alongside it is fine. Good addition to digestive enzymes since most enzyme blends don't have it.
Treating my dog with testosterone
Two years ago, our German Shepherd Chief was 11 and showing early dementia. He'd freak out at night, get glassy-eyed, jump on us scared. He was also wasting away while our other dog stayed healthy on the same food.
Both dogs are fixed. I figured, why not try testosterone. They're 80 to 90 pounds, roughly half my weight, so half the dose. I started with 100mg every 10 to 14 days.
Within six weeks Chief put the weight back on. The dementia went away. He just turned 13 this month and looks healthy as a horse. I do the same for our 10-year-old.
The only behavior change is they're a bit more territorial when marking on walks. Otherwise they're calmer than before, which surprised me. German Shepherds are anxious by nature, and ours have less anxiety on testosterone.
For a 20-pound dog, you'd obviously scale way down. Use peanut butter for the injection. They don't care what you do to them when peanut butter is involved.
Peptides for boxing/sparring (head trauma)
I played football for 16 years and acquired plenty of head trauma. If I had peptides back then, I'd have used them.
For inflammation, BPC, TB-500, and KPV. For brain-specific protection, Cerebrolysin is the gold standard. P21 is more accessible. PE-22-28 also works. Cmax with saline is decent. P21 and Cerebrolysin offer the strongest neuroprotection in my view.
Peptides and cancer
Most peptides are safe. I'd avoid growth hormone-releasing peptides and possibly BPC near active tumors, though there's actually data showing BPC shrunk tumors in mice. So who knows.
Immune peptides are great here. Thymosin Alpha-1, Thymalin, KPV. Metabolic peptides like MOTS-c and SS-31 for mitochondrial health. Take everything I say with a grain of salt, I'm not a doctor.
Hair loss on a GLP-1
Hair loss happens, but the GLP isn't directly causing it. It's like blaming the buzzards for the dead animal. The cause is the calorie deficit and the thyroid shutdown that comes with rapid weight loss. People losing weight that fast through any method tend to lose hair.
Fix the thyroid. Start with a thyroid bioregulator like Thyreogen, then desiccated thyroid, and only go to T4/T3 if you're severely shut down. Most people do well on desiccated thyroid.
IGF-1 vs CJC/Ipamorelin
Different tools. IGF-1 (especially IGF-1 LR3) is a direct anabolic for muscle growth. CJC and Ipamorelin are GH-promoting peptides that also help sleep, fat loss, recovery. Use IGF-1 when you specifically want muscle growth.
Microdosing Tirzepatide for inflammation, do you cycle?
You can probably stay on year-round at low doses. Tolerance and ADA buildup happen much slower at low doses. I'm leaning toward taking a week off every eight weeks just as a safety break.
If you need to cycle off, switching from Tirz to Reta isn't really a cycle since you're hitting the same receptors. Cagrilintide is a different pathway and works for some people. Orforglipron, the oral GLP-1 small molecule, is also a great cycle option. I think in two or three years, everyone not on an injectable GLP will be on Orforglipron.
Bipolar, ADD, and nerve pain
For bipolar and ADD, neurotransmitter-focused peptides can help. Cerebrolysin, P21, Cmax, Selank, Dihexa, Nupept. For nerve pain, ARA-290 is your best option. BPC and TB-500 help systemically.
Peptides for dog joint pain
Same as humans. BPC, TB-500, GHK, Cardalax, PEG-MGF. Scale dose to bodyweight. A 15-pound dog gets a third or quarter of a human dose. Big dog like mine, close to a human dose. Testosterone helps too if the dog is older.
Glow: 5 days on or 7 days?
Five days on, two days off is great. Seven days a week works too, you're not wasting money on the weekends off
Full transcript click any paragraph to jump video
Hey everybody, this is Hunter Williams. I hope you're doing amazing wherever you are in the world. Today I have the January 20, 26 Q and a video. It's been a long time coming. is I have a Q&A document link. It's actually the video suggestions or questions, which is in the description of every podcast or video that I publish anywhere. And what you can actually do, it's also in my footer of my email list.
What you could actually is go to that and submit a question and it goes to a document for me. and what I can do is, go through those documents or the document I haven't got to those questions and answer all of your questions in these videos. So if you want your question answered, you can go submit your questions to that link and I will get to it in these videos. Some of them, if I have answered it a thousand times, I'm probably not going to answer it. Or if it's a reconstitution question, i'm definitely not gonna answer just because that's outside scope of this video. I don't want to clog up the video with thousand reconstitutions questions of how much water to add to the vial.
but most of them, I would say 80 to 90% of are for good questions. And I've hand selected the ones I wanna go through today. and I still have 30 pages of questions from that document I'm gonna go though. So we'll see how much we get through. Maybe I get to all of em, maybe I don't, but there were some really good ones that I wanted to attack today and get there. Before I do that, as always make sure on the email list, that's the best place to avoid censorship and stay in touch with me. I'll just send notifications out about new videos or other things that working on. And then also too, make sure that you check out the Axion Collective. That's my private group.
If you do want your questions answered directly with me on live calls in the group, we do that every Thursday night at 8 p.m. We have a group call and you can come on and ask questions. And we also have weekly book club just for personal and self development in there. It's a really fun place. Also too you could direct message me privately to make you get your question answered. Then also we have an amazing forum of other users in their. I think there's like 220 people in Now at this point that are in there interacting and there's some really good interactions and stuff in the forum. But without further ado, let's pop over to these questions.
I've got them on a document right here and I'm just going to go through them one by one and let us get started. First one, pretty good question. I've read, there's some new research about VIP for pain. Have I seen any of this research? I don't recall any specific research off the top of my head. However, VIP is really good at downshifting a nervous system that is just really stressed out and in doing so can help with pain And so if someone is experiencing chronic pain, I would absolutely say VIP is a good candidate to use.
I've started like 100 micrograms per day. VIP, is really one of the most versatile peptides out there. So I highly recommend everybody use it if you get a chance to, because it does a lot of amazing things. Next question. Peripheral nerve injury. I was stung on a lower leg by a stingray. Man, I'm sorry to hear that. Cause loss of ops to try to heal the wound and nerve damage. Any suggestions for oral? Ideally not injectable. Peptides could help my damaged nerves. Don't know specifically about oral ones. You could try some of the oral bioregulators.
How much they'll help. Injectable ARE290 is probably going to be your best bet. The case of this, getting stunk by stingrays, no. Small thing, I would say probably four milligrams a day. Check that out. Next question. I'm a 50-year-old female, work out six days a week, lifting some cardio. Two questions. One, Ceremorellin, and I tried Tessamerelline, but had terrible joint pain. Do you recommend Ceremerellan and what doses? Sure. Actually, probably go to CJC 1295, no DAC. Before I go Cemerellen, they're both GHRHs.
I would actually try the CJC 1295 Nodac with the Ipermerlin blend, and I'll try that. If you wanted to do some Merlin, by all means, knock yourself out. Probably like 200 to 400 micrograms is going to be the dose for most people there. Next one, I have big whelps at my injection site. I take my glow peptide. And I'm taking several peptides. Another one's do this as normal. Yes, no, you are not allergic. After I changed the site to my hip and abdomen and it's the same no matter where I inject it. So this is kind of just comes with the territory. If you were injecting GHK or anything, meaning a blend with GH K, it was kind going to be the thing, and so that's why I am not always inject in GHk.
Although I love it, It is one of those ones that just you kind have to deal with it Is it good practice to take five amino-1MQ two hours before a meal? You could. If you're taking it orally, there's a school of thought that it's actually fat-soluble, so it is better to just take it with food. I think it would be fine to either. Instead of taking oraly, I'm injecting it now because I take the injectable so much better. There's probably a better answer, but you could probably do it both and still get the same effect. Again, it a small molecule, not a peptide. It works a little bit different.
Next question, HGH, I've been taking it consistently for at least a year. Am I supposed to cycle it also in the morning or evening? 62 year old female, 62 or female I would just stay on it. Just do it five days on two days off and you'll probably be fine. I don't really cycle my HGH that much. If I do I'm cycling with peptides, but I mean, honestly you could, you can do at all year and not really, don' see any downside of doing it all years. So if you wanted to, stop it, if your doing low dose you should be fun.
Next question, I want to try a GLP-1 was suggested to get RETA. I wanted to a three month protocol combining Reta with muscle preserving peptides like CJC and IPA, am on testosterone therapy, needs no timing, dosing escalation monitoring. How do you suggest doing this? I get confused with the mixing and I'm not looking to stay on a GOP1 long-term if I don't have to. Well, first I would dispel the notion that you don' want be on GOPs long term. They're great just for longevity. Now, do you want to be on a high dose long-term? I would say probably not. I don't know that we would want do that once we get to our goal weight.
However, I think it's okay to stay on it long term. But if someone's on testosterone therapy, a low dose of RETA, it starting at two milligrams a week, working your way up to two, four, five, six, whatever it ends up being that you need to beat, that's fine. And also too, just with every GLP, we should throw in a growth hormone peptide or growth on itself along side of it. If you're on Testosterone, why not go ahead and start Growth Hormone at a Low Dose 2-I-U, something that'd be good. but you could use tessameralin, you can use iprameraline, CJC, could tessemeral and ipraline. I love using growth hormone peptides in conjunction with the RETA because it just makes the muscle maintenance that's that much easier in a calorie deficit,
which is most likely what you're going to be doing when you run Reta. Next question, not sure how to find it. If you already spoke about it, why are you cycling on and off peptides? Why are some taken as needed and not daily? It's a good question. I've talked a lot about this, but I think it's just good to keep bringing up. With peptide, we get this thing called antibody drug or anti-drug antibodies, excuse me, ADA, anti drug antibodies. And what that means is the body builds up a tolerance, for lack of a better way to say it, to the peptide because the immune system responds to something
differently that's outside the bottom and you build up the tolerance to it. So where you then go is either escalate the dose to get the same effect that you were once getting and sometimes that takes a month, sometimes it takes six months, and it sometimes takes 18 months. before that happens, it just depends on the peptide and the end user. And so we, we built up this tolerance, but then the other option would be to cycle off. So let's say that we do a peptides for eight weeks, maybe we get good results, probably that eight week window on average with most peptids, were probably going to be experiencing some tolerance built up to it, and then we would cycle off for either four, eight,
six, 12 weeks, however you need to do it. And then when you start the peptide again, your body's not gonna be sensitive to. Do we have to do that with all peptides? I would say like most peptide is a good practice to. It's just that some will stop working. If you are taking them too long, it depends on the peptid, you know, as to how fast or slow it stops working, but that's typically where we're going to see. And that, that why we cycle peptids. There's people out there to say you don't need cycle. I mean, if, If. You don' want to, I'm not here to tell you, do you? You. Don't have. But I think it's best practice based on what I've seen based, on literature and based what.
In practice. Can you stack the glow blend with glutathione? Absolutely, you can stack those together. You just don't put them in the same syringe. Glutathion would actually be one of the things that would mess with the GHK. It would not want to put glow and glutothione in same Syringe, although that kind of be nice because they're two of most painful injections that most people do. What is the best peptide when working from home on a computer all day? After a while, I can't focus or be productive and engaged. Well, the body is not designed to work on the computer.
The best thing for me is I either take walks throughout the day. I will move around. desk or under my desk and walk while I'm at my desks. But I think the best thing is to one, just minimize your exposure to screens as much as you can. Now I realize that that's not possible for some people, including myself. So we have some of the nootropic peptides. The stock answer to this would be like, yeah, you could use C max. You could do C length. you Could use P 21. You could use even something like Nupep or Dihexa.
I think probably NuPep and DiHexa would be ones that would more of a brute force peptide to have a good effect to make it where you're sitting down at your desk and can focus. But again, just be careful because you don't want to turn into a robot, right? We don' want use peptides to turns us into robots. There's people out there that want do that though. Next question, are you using glutathione in a plus and read it at a maintenance dose per the cheat sheet not interested in losing weight, just metabolic health and lower oxidative stress?
My BMI is normal, but I have high cholesterol most likely from a high protein diet. Is there a peptide that can help a lower cholesterol without having to use a statin? Well, I would say RETA would be my first one that I'd go to. I think there's evidence around MOTC. Having some lowering of cholesterol, SS31, also through improving mitochondrial health as well. It's interesting. There's one peptide that directly is lowering LDL cholesterol per se. We do have these PCSK9 inhibitors.
The data seems pretty compelling on them. But I think to the point is some people genetically just have higher cholesterol and I we want to minimize inflammation and so that the cholesterol becomes much less relevant in the conversation of heart disease than it would be if there was inflammation, obesity there. But, I would say any of the metabolic peptides are going to do a good job of helping lower it. Glutathione obviously is good. Reta is I would also say get on an SGLT2 inhibitor like Jardians.
I've seen good things, at least in my blood work as it relates to cholesterol, because I'm one of those people that just genetically super low inflammation, super good metabolic markers. But for some reason, my LDL and stuff kind of hangs around the higher range. So check that out. Next question, I wanted to ask about retitrutide.I've tried several times to switch from trisapatite to this peptide, but each time it left me feeling extremely fatigued and very sleepy. I've added NAD+, started with the low dose and even tried microdosing, but I still haven't been able to shake the fatigue, which has been quite frustrating. I really wanted to experience the benefits of RETA, especially for muscle preservation and boosting energy and metabolic rate.
Do you have any ideas or suggestions? I do. First of all, do not feel like you shouldn't feel FOMO. around reddit if turzapetide does really good for you. I think it's one of those things in society where we're always like, what's the next latest and greatest thing and I have to be on it. And if I can't, then my life sucks. Turzapatide is an amazing compound. People do great on turazapitide. You can achieve amazing health benefits with turizapatide, I would have no problem right now if i didn't have reddita to get turrazapotide and use it to the same effect. Is redda better?
Yeah, i would say like probably, but for some people if you're tired all the time, Is it really better? I would say no, because you don't want to be tired all the time. Now, in my experience, the fatigue tends to go away after like two or three weeks once your body acclimates to it. And also too, RETTA is inducing more of a calorie deficit than trisapatite is. So you're going to get tired more so than you would be on trizapatide if you were introducing R2Tide because your burning more calories. A lot of times eating the same amount or less food than your would on Trisapatide.
It's one of those things I'd say Like don't get FOMO if Triseptide works great. But also too, if you want, give your body at least a few weeks. If you can make it through those few week, you'll usually be okay. And I also say too it's a really good time that you could bring in MATC or SS31. NAD is good, but I would say MAT C or S 31 is going to help more with the energy than probably N A D to do. You can use it in conjunction with N.A.D. alongside of it. Next question, my husband has had ulcers and very unhappy stomach. BPC started really helping about six weeks into it.
It says to go off for eight weeks. He's just starting to feel better. he doesn't want to stop just when he's seeing results advice. One, I would say in the case of that, to get back to the cycling point we were talking about earlier, i wouldn't say cycle off just because it's the eight week magic mark, right? Now, he could keep going 16 weeks, 24 weeks just know that the same dose is probably not going to have the effects for that time. I always say with injuries or in this case someone with ulcers, ulcerative colitis, whatever, stay on the peptide until you get healed. It's much better to stay in the peptide even if you have to up the dose as long as you can afford it than coming off the Peptide to get the body healed
to where it needs to be. However, in this case, we would have options like KPB, like VIP that we could add in or use as an alternative to BPC. Maybe use BTC for eight weeks, then you bring in KPV and VIP and that would probably have really good effects on the gut as well. Also another one I forget all the time, lorazetide, really for gut health and improving the got lining. Can you discuss types of inflammation and autoimmune disease and common peptides or peptide stacks to begin treating them? Sure. I mean, a lot of information A lot of autoimmune disease comes from chronic stress, mitochondrial dysfunction, and poor gut health.
And poor good health does not mean you have to be fat. It could just be that you were more susceptible to damage from glyphosate on your gut lining and you had toxins leaking into your bloodstream and got auto immune disease. A lotta times that happens to people. To answer the question, I think VIP would be like the first one for autoimmune diseases. I would say VIP, thymus and alpha one, thymaline, KPV are all really good. You could also try lorazetide. LL37 is okay, but sometimes for people with auto immune disease, it can kind of backfire on them.
So I'd say wait until you're a little bit more cleaned up to help with that. But those are where I start. Next question, kind of adjacent to this, we have allergies, what to do for allergies like asthma, hay fever, allergic to animals, whatever. I mean, my first one for that would be thymosalpha-1, I think VIP does really well for, that especially around the asthma thing because it helps with the lungs. You can also try one of the lung bioregulators, bronchogen or chonlutin, chondluten would the other one. if you wanted to introduce those. So you could do all of those together if want to experiment with a couple other ones.
I wouldn't say it's like, it would be a guaranteed fix all for allergies, but based on what I know is causing the allergy, those would probably help based the pathway. Next one, are there any circumstances where taking TRT and peptides is not a good idea? Let me think. I mean, I think it's always good to optimize the body. Right. If you're a guy and you are really trying to get pregnant with your wife, probably not the best time to start TRD. Although in some cases it could be helpful if you were dealing with fertility issues.
but I would say like, okay, if you want to have kids or like kids in the next two years, TRT might not be the best thing. There's stuff that you could do to maintain your fertility. If it was me, I'd probably start TRD just because I know how much better my life is with it. But I think in a lot of cases people like on the fence and it's like well I want have to kids the two next years. Maybe just don't worry about it, have your kids and then start as soon as you're done having your kid or whatever and you'll still be fine with the fertility Peptides, when would it be bad to take peptides? I think it's just one of those things, like if someone had active tumors in their body, I really wouldn't want to push a lot of growth promoting peptide,
mainly the GH peptidies. And so I would think that would be another instance. But in that instance too, there's a lots of peptoides you could do to help. So I wouldn' t say it' s a blanket statement to all the peptids. I'd think a testosterone would help in this case as well, but I'm not a doctor and don't take my advice. Next question. Would you discuss best uses in your clients have had taking bioamp, which is ATX 304 found one capsule on a sugar fast seems to give me great energy pre-workout. I'm wondering what other protocols you've seen success with. Yeah.
I would say this for me personally, I don't like taking BioAMP around strength training sessions. It's an AMPK activator. As far as I understand it, it exists more on this AMPk activation, autophagy side of the equation, much more than it does the performance enhancement slash anabolism side, muscle growth side. Through MPK activation, it's inducing autophagy. It's kind of helping with some of these pathways similar to like a metformin and maybe even a little bit of a rapamycin. Although I wouldn't say the mTOR inhibition is that strong from ATX, but I do like it for that reason.
I think it is a better version of met formin from what I've seen. the cardio is great on it. So you can definitely take it like pre-fasted cardio. I think it's great there, but I like using it pre fasted, cardio or, uh, just not around like the four hours of my strength training session. Cause I'm trying to force muscle growth during that window and then take after. And so if you strength train in the morning, take an afternoon or if your strength during the evening, taking the. Morning, I just noticed around strength, training, it seemed to make me feel weaker the same way. If I were to take like a bunch of Metformin around string training.
It just didn't, as strong in the workout, but it didn't seem to have like a cumulative effect. So when I stopped doing it around the strength training, it's kept taking it. I felt fine. It was just when i was taking around that training window that it seemed to not be as good. But other than that, I think it was one of those ones, just take it and it improves a lot of stuff. Next question. Can you stack CJC with IPA but also do Tessa Morellen with it or is there a specific window to separate them? say it's a blend of CJC with it, but you want to add test it too.
I personally wouldn't do that. And the reason is if we look at this CJ C and Tessa are both GHR H's. So from a pathway standpoint, they're redundant. Now, does that mean if you put both of them together, that we're not going to get more growth hormone? I mean, you probably will, I've actually done that before I have taken CJC, Tessa and IPA and it caused a lot of water retention for me to be honest, because there's companies out there that sell blends. That was years ago. I would say just use CJ C with IP or Tess with it because the IP is a GHRP growth hormone releasing peptide, whereas the CJ and the Tesser are CJ.
GHR H's. And so they kind of exist in the same field, meaning that they do the thing. So I think there's a little bit of redundancy. I personally wouldn't do it. Given the current state of research, Kim's is Carterine GW 501 516 still in your stack. Yes, it is. I still use it pretty frequently. Also use another one called GW 0742, which I think is a little bit stronger than Carterin. Same dose on that 10 milligrams, but I Think 10mg of Carterina is excellent.
Love it. Would just cycle on and cycle off because of some of the data we have around cancer, even though we do have some data that shows this is anti-cancer. And so you always have to take kind of some of that data with a grain of salt. But I would say that it is great. I'd keep it in the stack. Does GLP-2, AKA trans appetite, work for gut healing? It works amazing for good healing. I think that's one of those things that when we talk about microdosing, that is one the benefits, right? If someone has autoimmune or they got some gut issues, some leaky guts, irregularity, the micro dose can do well.
In terms of the bigger dose, if you were to go to a bigger does right away, I thinks some kind of backfire on you in that sense. So I would just start with a micro-dose, but yeah, just use a microtose if want to work on it. Stacking terzapetide and retitrutide can be done if you need the big appetite suppression from teres, but the body. higher metabolic benefits and body composition, benefits of Reto. Yeah, I've done this in the past before. I just kind of done it in a one-to-one ratio. So one milligram of RETO, one milligrams of TERS, two milligrams total. Whatever you stack, just be conscious, like whatever you're stacking, the total milligram amount I consider my total GLP load.
And so if I'm doing two kilograms of each, that would be four milligrams, total, and so like in my titration of how I am doing it, would just conscious like, okay, am I doing four milligram. But what it seems to do is offset Some of the appetite suppression or some of like the lack of appetite suppressant because of glucagon agonism, which is being driven by the increase in metabolic demand on the body, but when we introduced trisapatite, it kind of raises the ratio of the GLP and the
GIP in relation to that glucagon. And so we get more of appetite suppression. So what it's kind doing is minimizing the glucon agonism, but still getting it in there. If you wanted to stack them, that would be what that's doing. I don't know the ratios of like, okay, out of red, how much is GLB versus GAP versus glucagon? I know that answer, I've never been able to find that out, But when stacked them together, That's what happens. But yeah, I think you can absolutely do that. I there's good reason for some people that get too hungry on Retta to be able to do.
Next question would be interested to hear your thoughts on betaine HCL and how it pairs with or without pepsin. Seems like a simple supplement that could help a good amount of people. I think it's great. Actually have some betane HCl in my supplement pantry. which is rare, but if I ever get sort of like indigestion or heartburn or anything like that, I'm always using betaine for that.
And then sometimes too, maybe I'll just use it if maybe having a cheat meal or something, it kind of adds a little bit of stomach acid to help me break the food that I am not used to eating down. But I love betane, and I think pepsin is fine to add or add with it. Full disclosure I have to do my research. I don't know off the top of my head if they're good. but I feel like I've seen them together in the same blend. As far as the betene goes, It's another good thing to have in addition to digestive enzymes, because a lot of the digestive enzyme brands don't have that in there. Some do, but a of them don' and I love it to just help break down food.
I'd like to hear more about how I treat my dog with testosterone therapy. Is the dog fixed and what brought you to it? Dosing, blood work, info, et cetera. Highly interested in this topic. Well, I don''t have bloodwork on my dogs and don´t plan on getting blood on them. Here's what brought me to it. About two years ago, our German shepherd chief probably was 11 at the time. And he was in the early stages of dementia. He would freak out at night. So he wouldn't know where he. Was he would go crazy and like we'd be on the couch at. Night and he, would like, he'd like kind of like start this thing where you like look around and get like glassy eyed and then he with get scared and they
like come up to you and, like paw you, and try to like jump on you because he scared, didn't what was going on. It was really sad, right? And it was like, obviously dementia. And then also at the same time, he was starting to kind of waste away. We almost thought he had cancer or something. Maybe he did. I don't know. He was just getting really, really skinny. This was eating the food that the other dog, we have another German Shepherd that is now 10 years old, so he's three years younger than Chief, our oldest dog, and they're eating the same food. He was staying healthy as a horse and Chief was losing weight.
I was like, okay, well, let's just try this. Yeah, we can give him some peptides, but he is fixed. Whenever he was young, Taylor had both of the dogs before I met Taylor. And so both of them were fixed and I was like, well, let's just start giving them some testosterone. And, so what I started doing, I didn't really know dose, but I'm like okay, my dogs are like 80 to 90 ish pounds and 200 pounds. So I take 200 milligrams of test a week. Let's give them a hundred milligrams, of tests. What I, what did I start doing? I just gave them 100 milligrams in one shot every like 10 to 14 days or so.
Cause obviously like doing a shot on a dog, you gotta give him peanut butter. You gotta like, okay, like come here. Cause they don't want to like feel the, the injection. They'll like kind of like run off. Although sometimes I don' give them peanut butte and I'll just inject them and they're fine. Uh, they dont seem to really feel it, but if you give peanut, butter, They don''t care. Like they'll let you do whatever to them if they''re eating peanut Butters. So usually Taylor would just get like a little spoon of peanut Butter and then I''ll give em their shot. A hundred milligrams every 10 to 14 days. The only way I came to that conclusion because they're like basically half my weight. So they get half the dose. However, I will say it has massively improved his health.
He, within like six weeks, he like put all the weight back on that he had lost and his dementia has gone away. And so now he turned 13 actually this month and he is healthy as a horse as it appeared on the outside. Who knows how much longer we have with him. I'm getting German shepherds usually don't live to be 13. years old, but I also do the same thing for other dog. He's 10 now and he obviously was healthy too, But I was like, he's been fixed. So he'd probably do well with testosterone. But yeah, they did. They did really good. I think the only thing that I would say is like different from their behavior is they're a little bit more like territorial with where they urinate.
And so when we take them for walks, They're like a bit aggressive in how they will mark their territory and they like to lick where other dogs have urinated. So I don't know if that's a testosterone thing or if it's the thing that like dogs that aren't fixed do as much of. They just didn't do that before. But as far as behavior wise, they're actually, I'd say they are much more calm with the testosterone than without it. You'd think that maybe it would make them aggressive. know they've been much more calm. Again, German Shepherds are kind of known to be anxious dogs because they're meant to guard dogs and meant working dogs.
And so if they are more like in a pet type environment, like ours are, before I started giving testosterone, I noticed more anxiety. After they seem to have less anxiety, but They love it. And he's 13 going strong, no more dementia. He's pretty muscular now. Actually, it doesn't look like a bodybuilding dog or anything like that, but pretty cool. I don't think there's much more to say than that. You just give him a hundred milligrams every 10 weeks. Or 10 days, not 10 let's say for a female dog, it'd probably be a little bit different.
I would probably scale down the dosing to like five to 10 milligrams. Uh, if they were the same size, obviously for, a lesser size dog. Like if a dog was 20 pounds, you probably wouldn't give them the, same, the dose of testosterone. Just be smart about it. Next question, what peptide or peptides stack would you recommend for neuro protection repair for weekly boxing or sparring sessions? It's light sparing with most guys in their forties, but still don't want to risk major damage or at least minimize small amounts of. damage with peptides, if possible.
Yeah. I mean, as someone who heavily engaged in the act of acquiring head trauma for many years of my life, let's yeah, 16 years, I'm playing football to where I was getting pretty much around the year hit in head pretty violently. And back then, and I think they're better about it now, a lot of coaches and protocols are better about not having the head contact. But back when I was playing, you had spring practice, summer practice and obviously the season. And you just kind of went full speed during all those times.
So would I trade that for the world? I don't know. I wouldn't go back and change it because it made me who I am. but I do watch I had peptides. I would say BPC, TP500 are always great to use to help bring down inflammation. And I think KPV is another one as far as inflammation goes to bring it down. Then I will look at something specific to the brain. Obviously cerebral isin would be good. That would something if I was doing sparring still at this age that I use. P21 would great, a little bit more accessible.
PE22, 28, another good one. C-max and saline could be good. I think there's more, a little bit more protection from the P21 though and cerebral isin. But I, think, you know, BPC, TB and KBV would all be, good as well. It's just to help with systemic inflammation. What peptides are safe or helpful for cancer? I mean, pretty much all of them are save. I would say like maybe with the exception of the growth hormone releasing peptide and then maybe like your BPC, like I wouldn't want to inject a growth
promoting peptid into a cancer tumor. Obviously that might not go as well. Although there are studies to show that Bpc shrunk tumors in mice. So what do we know? But I will say any of the immune peptides would be really good in this case. Obviously, I think some of them metabolic peptide to MOTC and SS 31, it could be good just for mitochondrial health. But don't obviously take everything I say with a grain of salt, because I don' know everything. I obviously don''t claim to know everythin, but I would say those are great. And then any the immunopeptides, thymidosalpha 1, the thimalin, KPV, any those ones that help suppress inflammation, help stimulate the system,
i think would Next question is peptides post concussion. Pretty much the same thing I just said for the sparring session, except post-concussion, if it's like a bad concoction, I would make sure that you're doing like, a higher dose of cerebral isin would be good. This is one question I get all the time, and here's what I will say about hair loss on a GLP-1. Does it happen? Absolutely, it happens. It's kind of like saying that the buzzards killed the animal on the side of the road, though. The hair lost is not caused by the drug.
the neuroendocrine system, the shutdown in the thyroid system and the starvation mode that the body is basically in because the GLP is inducing a calorie deficit and causing weight loss. And so if you took all these people that are losing hair on a GLp, And you just had them lose weight without the GLP, especially in a way that is the same speed, meaning that they're losing weight at the rate through starving themselves, because that's kind of what we're doing, right? Most of those people would have hair loss as well. And the reason is, I think my theory is that it's shutting down the thyroid.
So how do we do that? Obviously optimize thyroid function. You can start as low with a thyroid bioregulator like thyreogen if you wanted to, and then you could go next to a desiccated thyroid. I think that's where most people do well. And then like the higher end, if he were like a really, really shut down would be T4 and T3. But I don't think, I that that is probably over prescribed to people, whereas I most think people will do in the desicated thyroid range. My answer to that would be check your thyroid because of slowing down, because the weight loss, and then get on a desiccated thyroid or a thyroid bioregulator.
Next question, IGF-1 versus CJC and Ipameralin, they're kind of two distinct things. I view IG-F1 is more of like a direct anabolic tool to help build muscle, whereas CJ-C, and Imamerelin are going to be growth hormone promoting peptides. They really do a whole host of things, including building muscle and burning fat, but helping us with sleep. And I don't know that we get so many of those benefits with IGf-I as much as we did just a little bit more, especially IG f1 LR3, as a much that would get just little more like anabolism or muscle growth specifically.
And so I would say that would be the use case if you were comparing the two. Next question, for those of us microdosing trazapotide for inflammation control, is it necessary to cycle off or can we just do it for life without risking desensitization? Answer that question first, because there was a second part to that. To answer that, I think you can. I'm becoming more and more of the opinion that we probably need to cycle it a little bit, but that can stay on it year round. And so maybe we take a week off every eight weeks.
So go seven weeks, take a week off, and then go back to it. And I think over time, what we'll see is just that the inflammation continues to improve, continues go down, the person continues get healthier, And then you get to a point, cause like these are pretty new, right? So like maybe we do this for four or five years, now the persons super healthy, then they can go off for a month or two if they want to. Obviously you want have your diet and lifestyle in control. But I thinking of low dose, The tolerance and the anti-drug antibody buildup, it takes a lot longer for that to happen to lower dose.
Whereas if you do a higher dose, obviously it happens much faster. And so I think that's fine. The next part of their question was, if we have to cycle off, is RETTA a sufficient cycle protocol, or we need to get off GLPs entirely for the cycle-off phase? If we needed to take off GOPs, entirely, what other PEPs would you recommend to fill the gap? I'd think you could obviously go to coagulantide. I don't think like going back and forth from TERS to Reta is really not doing anything because you're getting the same agonism out of the receptors. There's just an extra one in RTA. You could switch to coagulantide if that works for you. Some people it doesn't work for because it's a whole different pathway.
And then also too, there's the oral small molecule or for glipron. I think that's actually good because even though it is a GLP-1 small-molecule agonist, I have found that you can cycle off the GLP, use Orphor Gleprin, you use it for four weeks, get good results, go back on the GLP and you still feel pretty doggone sensitive to GLPs. And so I think that would probably be the answer and Orphor Gleepron will probably like two or three years from now, everybody that's not on an injectable GLp will be using it. It's just that it's so still in the fringes of the research world.
Next question is kind of a tough one. Peptides for bipolar, ADD, and nerve pain. I'd say the bipolar and AD, I mean, cerebral ISN, P21, C-max, Solanke, dihex, a new pep. Sometimes those can help some of those, because if it's a neurotransmitter imbalance, those could definitely help. For the, you know, the Bipolar AD. Nerve pain would be ARE290. BPC and TP500 could help as well, but ARET90 is going to be better. Got another dog question.
My dog is having joint pain due to old age. And I was wondering if you talk about dogs and peptides on joint paint. Yeah, I think obviously I, was saying earlier about testosterone, testosterone can be good for joint, pain, especially if it's an older dog, but BPCTB 500 pretty much the same things you would give humans. I would say scale the dosing maybe to the weight of the dog. You know, so if, you have a big dogs or big dog like I do, you know, you could probably do the same human dose or maybe a little bit less. If you have a 15 pound dog, probably a third or a quarter of the dose that you would give to a human.
But yeah, same ones that would use PPC, TB 500, GHK, Cardalax, PEG, MGF would be for a dog as well. Dogs respond really well to it in my experience. I've been seeing conflicting dosing frequency for clow. Some people say five days on, two days off. Lately I have seen all over Reddit that people are saying you need to take it every day, seven days a week, otherwise you're just wasting your money. I don't know. Five days, on two day's off is great. Seven days is, great if you do it. If you are taking the weekend off, you aren't wasting money, it's still working.
But it is just one of those things that I think doing it five days on and two days off, to go back to the sensitivity and the tolerance buildup, when we do that, we're kind of giving ourselves like a micro break that allows us to stay on the peptide longer without having so much of that sensitivity. Because if you think about it, if we take the weekends off over the course of a month, that's really eight days. That's an entire week that you took off of the Peptide. And so instead of staying on for eight weeks, you know, if you think about it, you were on for four weeks, but you're really on three weeks.
And so what you could do is if do that for three months, all of a sudden you've given yourself another month of the peptide that you kind of probably put yourself in a position where you had less tolerance built up to stay exposed to the Peptide. You're definitely not wasting your money, it's just kind what do you want to do. But if your hurt and you are injured, maybe you do stay on it every day because it would be better to, right? And there's no black and white answer, that's my opinion. Here's a good question. I said no reconstitution questions, but this one's actually, I think would be helpful to people.
Does it matter how much backwater we add to a peptide vial? I'm going to start glutathione. My vile is 600 milligrams and it's suggested I add three miles of back water. If my dose is 150 milligrams, that would 0.75 ml or 75 units on a syringe. Correct. Could I just add one amount of backwater and take a 25-unit dose instead? Probably not with glutathione. The thing with gluta-thione, this is also the case with NAD, if you have lyophilized NHD, is that a lot of times because the vial is bigger, the molecule is big, there is more actual substance in the you need more water to help dissolve it.
And so in the case of glutathione, you could try, but guess what? It's probably not gonna break down all the way. So the powder won't fully dissolve. Although it sounds like a good idea, if you try it, it's not probably gonna work out. Again, same thing with an AD. I've tried that and just what happens, because I thought the same before, is it just doesn't end up dissolving in a way that you needed to dissolve? A great idea but also practical. It didn't apply in practice.
This is a good one. And I don't, I really know, but someone said, as I was curious if there's any research or peptides or bioregulators for hyperthyroidism or grave disease, meaning their thyroid is overactive. Yeah. I don't think desiccated thyroid would always be the answer here because obviously that can like stimulate thyroid even more, which is not what we want. However, I think the thyroid bioregulators, thyreogen, can actually work pretty well here, because those are modulators of tissue. And so it goes into the DNA of the thyro tissue and says, hey, we're overactive.
We need to bring it down. So that's what I would try if there were one that you wanted to try for hyperthyroid, or Graves' disease. Can't guarantee that it would work though, just because I haven't seen it in practice. Although it may, I just have never heard from anyone that says it does. Actually, same question about peptides and cancer. Would peptide be safe for cancer? What do you do for loss of cartilage behind the kneecap? The first thing I would do is try cartilax as close as you can to that site and see if it helps regrow it.
If not, you're probably going to have to go to like exosomes or something of that nature to see it if helps. But again, that's not guaranteed. It's just one of those things that everyone's going be a little bit different. Next question is a little bit long one. My husband has a very mild form of myotonic muscular dystrophy. You can't tell by looking at him, but everyone else in his family with MD died young and he's the only one left sort of anomaly and just celebrated his 49th birthday. Congratulations. Do you have a stack for any and all muscle wasting diseases? I think I don't, again, this is just complete speculation.
Obviously, anything with mitochondrial health, I think it's going to be important to like MOTC and SS31 in this case, would be huge for someone with muscle wasting disease because a lot of times there's mitochondria dysfunction there. I would also say probably some sort of hormone therapy. Again, i'm not a doctor. i don't prescribe testosterone, but i would imagine that that would probably help somewhat with the muscle-wasting. Would it solve it? I don' know. But i think the mitochondrium peptides would the first one. maybe a growth hormone peptide, but again, I can't speak to that just because I've never seen it work in practice. But based on the nature of that, it wouldn't be harmful.
This is a good question, and one I actually found the answer to recently. There's a lot of this stuff called cerebroprotein hydrosylate, or hydrolate something going around. And basically what it is, is cerebral liacin and 60-milligram liapalysed vials instead of the ampoules. Is it the same exact thing as the cerebral isin, the amples? I don't know. but it's a much smaller dose than the cerebraliacin. So if I was going to use cerebelliacine, I didn't want the big dose for the Big Therapeutic Effect. Typically, like a 10 milliliter ampoule of cereblaliocin has 2000 milligrams of Cerebralliocid.
And so if you're doing five MLs, that's like basically like 1000 milligrams or a whole gram of cerebral liacid, which is a lot, right? But sometimes if someone has a stroke or concussion or things of that nature, they need that much, you know, for a pretty extended duration, sometimes for one month or two. However, there's all the rest of us that just say, hey, I want some cerebral ising because I wanna, you know, feel good, right? I don't wanna be a super computer. I wanted to be like Bradley Cooper and Limitless. And this is where this lyophilized powder would come into it. So if you can source it, it would be great.
What I have seen is that most people take like, 20-ish milligrams a day at nighttime with that to kind of get the bump without having this like huge spike. If that's what you wanna do, 60 milligram vial, add three ml, or excuse me, one ml of water intake, you know, 33 units and there you go 20 milligrams a night and you'd be on your way. That's what I would do. I actually probably do that because I do have some of that stuff. The cerebroprotein hydro hydrolysate Best peptide stack for women over 60 for longevity, menopause, mitochondria as well.
Also they need to be cycled off. What would be the next after cycling off? I'll say first thing first, obviously testosterone. Obviously if you need it, estradiol. Well, I would say obviously progesterone almost always. From there, that's going to solve 90% of the issues. And so if women just had injectable testosterone and then progesterone and then injectable estrogen if they need it. That would solve 90% of the issues. And then we can just talk about peptides for fun, instead of saying that like we need the peptide to solve the problem for us, because we're not gonna solve menopause with peptids.
Menopaus means you have no hormones. replacement to solve it. We need testosterone for women. In some cases, estradiol for woman, not in all cases. And then also you need thyroid support for them because those are no longer functioning when you have gone through menopause. So once that's off the table, yeah, sure. We can do MOTC. Sure. we can. Do things like kiss, pepton, maybe for some sexual function and arousal. Uh, we could do SS 31 for mitochondrial health.
So it's really not that different once the hormones are addressed. The problem is like most people just don't do those things. They don' menopausal women injectable testosterone at 10 to 20 milligrams a week. They don't give them progesterone. they don' keep them desiccated thyroid. If they need it. And so we were just running into the issue of not addressing the hormones and then we're trying MOTC or GLP and it works for a little bit, but then there's still an issue, right? Cause you don''t have testosterone. if I didn't have my testosterone, my testosterone would be zero. and that I would use a Motsy. I'm like, it kind of feels good, I still feel depressed or I feel anxious.
Well, yeah, cause you dont have to testosterone Next question, I'm gonna start TRT at the beginning of the year. What should I consider as far as stacking on top of TRTs? I mean, I think with TRT, it's kind of one of those things you like don't want to throw a bunch of stuff at it because you want go through this like, you know, three to six month warmup phase where you're starting testosterone. But I would say like the adjuncts to TRTs that are not like fun peptides to experiment with is going to be desiccated thyroid almost always, but you might not want start it right away. I'd think it'd be fine if you started right way. but I like to start at least testosterone for three months and then introduce the desicated thyroid.
And I metformin is great to have met formin or an SGLT2. And then growth hormone. Then I would say just get on growth. Hormone. If you want to have one or two, I use a growth or more alongside of it. It does really well. And especially too, if there's pituitary dysfunction, the growth, hormone really works really What do you think about in clomophene for upping testosterone while maintaining fertility? It's better than nothing, but it sure as heck is not testosterone. And so I don't want to say it's worthless because there's no use case for everything, But I will say, it pales in comparison to testosterone,
But if you want to use encomophene for a year or two, I just don't think it's a long-term solution. So maybe, you know, for that guy that wants to have kids right now or in the next two years, he doesn't comophane and set up testosterone, has his kids and then gets on testosterone. I would say like that's the best case, but it definitely is not something that you're going to used for life and think that it is going replace your testosterone just because it doesn' I haven't seen that work well. So I'm going to ask, what do you think about SARMs or steroids? I think steroids are great.
We have lots of data around steroids. Should you choose to go down that path? Not a big fan of SARMS. I mean, I am sure there's some that kind of have a good effect on people, but long-term we just don't know. And they didn't work out in practice, at least from a data standpoint, relative to some of the anabolic things, which we know work and we are pretty safe. You know, it's funny. Always like not to get on a soap box. People like poo poo steroids, you know, steroids are so bad, like you have all these issues with steroids and stuff. The same people that do that will drink alcohol two to three times per week.
If you said even like a hefty steroid cycle and did that for three months out of the year for life and then said, I'm not going to drink. I think philosophically speaking, You're going be in a way better place using the steroids. And not drinking alcohol. but that's just my two cents. It's one of those things. I hate that people say that about steroids because I think there's a use case. One of the things I've thought about talking about again, just on the soap box for a second, it's kind of like the nature of anabolic microdosing.
And you know, in the steroid world, obviously it is tied to bodybuilding and we have people in the bodybuilding world using steroids. But no one really talks about it's like how you can microdose little amounts of steroids to get the physique that you want, which is not a pro body building physique, but just enhance muscle tissue on the and then come off of it and cruise on your therapeutic hormone dose with that muscle. That definitely can be a real thing for people is to add in a little bit of an anabolic and use that to put on muscle, not to the point where we're becoming
a bodybuilder, but just to where feel comfortable with muscle and just keep that muscle for life because muscles are a metabolic currency. And so that's one thing I'd love to talk about. Obviously I don't need any help getting shut down off of platforms, but I think it'd be cool if I did some, some content on anabolic microdosing. So if you, you know, in the comments or messages you send me or whatever, let me know your thoughts on the anabolic micro dosing. Cause I love it. Say like, okay, Let's talk. You know what does for a guy like 50 to a hundred milligrams of primo per week look like?
you know, two months out of the year, three months of a year to help put on some muscle and then come off and retain that muscle with our hormones. You know? And instead of blasting crews, maybe we would just say, you press a little bit on the gas pedal and cruise, if that makes sense. So. With so many peptides by regulators, it makes your head spin. What would you consider the staple or core for a healthy 52 year old male that's fit for longevity and muscle growth? I think to go back to those things that I was talking about with testosterone, I would say for healthy fit 50 year-old male,
here you go. testosterone, desiccated thyroid, metformin plus an SGLT2, two I use a growth hormone, a microdose of a GLP. And then if you want to throw in somati and SS31 and you'll be pretty good. The rest is kind of just fun to play with or like use use cases. But I think for the purpose of saying like, what's the bare minimum, you know, if I said like okay, like the bear minimum that I need, pretty much those things. If you have those, things you can have amazing health, a great physique, as long as you take care of yourself and do everything else right.
And so I would say that's kind of the staples and then the rest is as people like to accuse me of just people trying to sell stuff. So. My father has MRSA and it's through his whole system and he isn't doing well. I don't know how much longer he has to keep fighting.
I mean, LL 37 could potentially be a good one. I think at the very least KPV and thymus and alpha one would help bring down the inflammation there, which would be good because it would stop the body from having this like, you know, obviously. pretty dramatic response to the infection, but in some cases like that, you are going to have to use the antibiotic. So I pray and hope your father gets well through that. But those would be the ones I would go to first. Probably KPV would Hormone peptides for women, what are the optimal levels, especially when it comes to testosterone?
Well, there are no peptide that are gonna raise your hormone levels to get to where you need to be. And like I said earlier, that's where we rely on testosterone and progesterone and then estradiol if we need it. But I will say, for optimal levels. I think most women do best when their total is over 200. And I know that would sound really high to some people, but I've worked with tons of women.
They're free anywhere between like three and seven seems to be really good. Some women like it higher, like at the 15 level. And I think that's cool. As long as they don't get too much masculine, too many, you know, masculinizing side effects. The thing with women is even with that, it's really hard to say like the range is going to good because one woman, one women could feel good at like an 80 total testosterone, but another one could still have low testosterone symptoms. Even that it is like higher than the reference range. I would just say it's always gonna be a little bit different, but until you get your hormones, and this goes for men or women,
until we get our hormones addressed, none of the peptides are gonna do what they can do. How many peptide can you stack at one time? You can stack all of them at once time. No, I'm just kidding. But I'd say probably I don't like more than like five, seven peptids at on time, doesn't mean that you can't do that. I just think at that point it becomes like, okay, what's the goal? What are we doing here? If we're doing more that five to seven peptides, like what am I actually working on? Or am just buying stuff because it sounds cool? And I think that's a case. Oh, kind of actually related to the last question or one of the previous questions.
What peptides should be on a very short list due to cost and a bit of fear too for an aging parent? Kind of like I just said, if you had testosterone, desiccated thyroid, growth hormone, microdysureta, and MOTC and SS31 would be great. Aging parent that's 87 years old, overall good health, but does take medication for blood sugar, cholesterol and has never used HRT but has had signs of dementia. Yeah. I mean, if you have signs of dementia, I would probably get cerebral isomer right away. That's going to be more of the bleeding neck problem than the hormones will, although the hormone will help. As I discussed with my dog, what I'd love to see is there a correlation.
Let me go look this up and I'm done with this video. Has anyone ever looked at an analysis of testosterone therapy and dementia risk or yeah. Dementia risk with testosterone. Therapy. Would love see if there is any sort of correlation, positive correlation between testosterone therapy, or I guess it would be negative correlation because we want to see testosterone on therapy with decreased dementia risk. So interesting thing to look up. I'm actually going to. Look that up when I am done here, but I do think to the point hormones help us become more metabolically healthy, which stops neurodegeneration.
Cause a lot of times that is a metabolic issue. Just going through. Yeah, for people that can't get desiccated thyroid, the thyroid bioregulators are good, although they will never replace desicate thyroid. But if you can get a desicated thyroid please at least try the Thyroid Bioreglators. Someone asked about that. I've never seen this before and I don't, I would say it's not true, but someone said I read that injectable carnitine can blunt the effectiveness of thyroid
function and thyroid medication such as desiccated thyroid. Is there a merit to this? I have never see this. I haven't ever seen it in practice. Never seen any data around this, if anything, actually I think I looked this up one time because someone had asked me before. If anything it enhances thyroid functions. So I'm not sure where that came from, But in my experience, no. Not saying that definitively, just in experience I'd say no I'm curious about the different mechanisms of action for GHRPs and GRHHs other than stimulating
the release of GH. For example, I hear testosterone targets visceral fat and improved sleep. Are these effects coming from something different than an increase in IGF-1? Or can I get the exact same benefits from increasing HGH? But I am not seeing unwanted side effects taking that approach. Well, testosterone, well, let's explain this first. Testosterone is a GHRH, growth hormone releasing hormone. Ipromelan is GHRP, Growth Hormone Releasing Peptide. Impramelane is agonist, meaning that raises ghrelin, but what's cool about impramelane, is it does so without increasing hunger or without increase cortisol
or prolactin. Which is cool because we get the increase in the ghrelin without those things, and then that leads to more growth hormones, which then gives us those benefits. The GHRHs do it through a little bit different way, kind of a bit more complicated, but they do and so they're different in terms of how they that, which is why they work a lit bit differently. And also, Tessamerelin probably is better for belly fat than CJC is because it's a lil bit stronger. So at the end of the day, yes, the increase in IGF-1 is what's working, But there's different mechanisms by which they are doing in the brain which ends
up in, you know, similar effects but maybe not identical. Related to that, we have MK777. Now, I will talk about MK777 in the most anecdotal fashion possible, because that's all we've have. I haven't seen any animal data around it. Haven't see any human data round it, but I have anecdotally experience with it though, and I've thought it is great. It doesn't increase prolactin or cortisol, it's almost like an oral version of Ipameralin to me because you get all the benefits of MK677 without the side
effects of the bloating, the water retention, the increase in hunger, or the increased in prolactin and cortisol. And so I love MK77. Now granted, I haven't done it for more than like four weeks at a time. Sometimes what I'll do is like I do that one night and then I will do HGH one and I go back and forth between those two. But I've done the 10 milligrams and it works amazing. I, love the MK777 I think it's good. The thing is I just can't talk about it from a data perspective because we don't have it. And so to my knowledge, it was just an improvement on the MK 677 molecule to not have those things and kind of have the same effect,
but I love it. I think it's great. PE2228, would love one on this peptide. Have you tried it? Tried it with, or there's a blend with C-Link, Cmax and Penelon and would like to try it. I like P22-28.I'm working on a video on it right now. Recently tried. It, I would say the feel is very similar to P21. So I liked it for that reason, albeit it's different mechanism, but it is not one of those things that doesn't like make you stem out or make your race here or anything. But I will say to someone's question earlier about, Having a peptide that you can sit and work at a computer, it does help with focus in that sense,
not as strong as something like modafinil or even dihexarinupep, but I do like it. It seems to perform well. SHBG, sex hormone binding globulin. How to fix it if too high. how it works, how to optimize. And so typically I will say for a man, cause women are a lot different. So I'll answer for man cause SHPG for women can be all over the place for bunch of different reasons. But for men, usually it's a men asking this. It's usually high for a couple of reasons. One, the person or the man is too fat, so he's got too much body fat to which getting the excess body that will bring that down to,
which it will free up more testosterone. You'll have more free testosterone The next thing is mineral deficiencies. And so sometimes with zinc or boron, we can bring that down and then it frees up more testosterone to have more free testosterone. A lot of times too is lifestyle things, stress, lack of sleep, all those things. Insulin resistance can, bring SHBG up. So the short answer is to like be as lean as is healthy, supplement with minerals like zinc and boran and also make sure that you are just doing everything
right from a lifestyle perspective and you should be good. Peptide stack for chronic psoriasis. I think I would say something similar to what I said about the autoimmune things. Cause I've kind of used psoriasis in that auto immune bucket. KPV, I thinking in this case, LO 37 would be totally fine. VIP, thymicin alpha one, thymolyn, and probably even a little bit of a SS 31 would do well. But I, think all those right there are going to help bring down the inflammation to which you would probably see a reduction in psoriaasis.
Optimizing hormone levels without raising blood pressure. I think the answer to that is easy. It's, you got to do more cardio. So many guys get on testosterone therapy and their hematocrit and blood goes up. And again, we could blame the testosterone for that, but I would tell you if that person is doing cardio every day or even if they're just walking 10 to 15,000 steps a day, it shouldn't be an issue. Now, there are some other circumstances. So yeah, you could throw in like one milligram a day of B733. That's a peptide that helps bring down blood pressure and helps with fibrosis.
And so yeah you can do that absolutely, but it's just not going to be one of those things that I would say is like, do we want to do all the time? Or do want address, like you know, it is good to exercise, right? And before we reach all these interventions, are we doing everything right from a lifestyle standpoint? I've heard several references that antibiotics are bad and should be avoided. Can you explain why these are and why they should avoided? Can also share what you would use in place of antibiotics? Okay, so here's the thing with antibiotics. I have had them obviously in my life before.
Some were good, some were bad. It depends on the one. Depends on use case. Is it a short term thing or you like using it long term? Obviously you wouldn't probably want to use it. Long term because there's going to be some pretty nasty consequences of that. However, I think As long as it's not like a diary issue to like the point of a question about Mercer earlier, you're gonna probably have to take antibiotics for that. But like, let's say like oh, well, the doctor is going to prescribe you an antibiotic because you've got the cold, like no, I'm not taking that. No, thank you. Like I've gotta cold but I don't need an antibiotics.
I can take some LO 37. And I could take something that's alpha one, kick the coal in the butt and then be on my way, right? And so I think it depends on how often we're using them. What's the use case? Cause in some situations you do need them, but then, you know, if it's like okay, Like have strep throat, Let's use some peptides and get over that as quick as we can rather than relying on an All right. We're getting about to an hour. So I'm going to answer a couple more and then we'll shut it down. Servo-Dutide versus Retatrutide.
Think of Servodutides. Retratrutides is GLP plus GIP plus glucagon. servodetide and mazutite, they both they're different peptides, but they are the same thing. They are GLPs and glucagon agonists. If we took the G.I.P. out of the retratutites, that's what Servo Dutai does, I haven't used it yet personally. I probably will get some just to play around with it and see, especially with people, even though I think the fears are a little overblown, worried about not getting Retta. But I would say I don't think it's going to be as good as Retha, but it could be a viable alternative if for any reason someone doesn't like Reta.
Now, the reason usually people don't like Reta is because it makes them hungrier, which I think stems more from the glucagon activation. But who knows? Until you try it for yourself and see, everyone's going to respond a little bit different. Thank you, Hunter, for all you do. I'm a nurse practitioner. And frequently see patients struggling with HPA axis due to chronic physical and or emotional stress.
That's what I'd love to learn about the most effective peptide for restoring healthy HBA axis function. We'll close on this because there's some things that we can do for this before, you know, depending on a person's age that you would say testosterone therapy is absolutely necessary. Obviously testosterone on therapy would be the gold standard intervention. If they're shut down, What do we do? However, I think in a lot of those cases, like this person is saying here, physical and emotional stress is causing a shutdown to which we can kind of use some peptides to come and say, hey, let's calm down the nervous system. So the first one would be a VIP.
VIP tends to have like a very calming effect on the nerve system, which is going to stop some of that emotional and physical stress. Hopefully if the environment is changing to, to be in better situation. From there, we could use something like C-Link, which is going to help also calm down the nervous system. And then in regards to the HPA actually working better, We could definitely use like a kids' peptin. How much benefit are we going get out of that relative to hormone therapy? It's going be a little compared to a hormone, but it could be beneficial in kickstarting it. I think in guys, you could probably use HCG.
Depending on the age, You might not want to do that for a woman because it can induce ovulation. Maybe you do want use that if you're working on getting pregnant, I would say VIP, C-Link, and then, you know, KPV would also probably be good too, because people like that probably have a lot of inflammation, which is kind of creating this vicious feedback loop that's causing the HPA access shutdown. And then you, know KissPepton, men or women could use, a guy could also use HCG and they'd be on your way. And that puts us right at one hour.
Thank you guys so much for these amazing questions. I didn't get through all of them, but I promise I will pick up where I left off and continue on next month in February for the February Q&A. But that being said, continue to submit your questions, link will always be down in the description of these videos. These are so helpful for me, guys. I can't tell you how blessed I am to have these from you guys because it helps make the content for be relevant to you, but it also gives me good insight on where everyone is at. And I always kind of have a theory that if one person is asking it, there's probably 10,000 people out there that are thinking it and would like to hear
the answer to it. So that's why these are helpful. That's what these episodes do so well. Usually these were some of my more downloaded episodes because people love to here these and even if it's not for them personally, maybe they pick up something for their friend or family. they can share with them. But anyway, in closing, thank you guys so much. I am so honored and blessed and privileged to get to do what I do. Just wanna always make sure you know that and whether it's sharing, liking, commenting, subscribing my material, using my code at places, signing up for the email list, joining my private group, whatever it is, whether its like directly financially to me or even just indirectly supporting
the content, I cannot thank enough. It means the world to be that I get do this, the dream come true for me and so I hope that comes through my materials. And I promise as long as I'm around, I'll be doing this and giving back to you guys because it's done so much for me and just the relationships that I've built with people I know in my audience and even from afar, it truly is humbling and I have so gratitude for that. So thank you, guys. Again, don't forget to submit your questions and i will see you in the next one. Peace.