Peptide Q&A · October 2025

0:09 Hey everybody, this is Hunter Williams. I hope you're doing amazing wherever you at in the world. Today is Friday, October 3rd. Probably be releasing this video next week, but it's been about two months since I've done a Q and a video. Think the last Q&A video I released was in July. So I have here with me over 50 pages of questions that have been submitted to me. I don't know how many I'm gonna get through, but I am going to do my best to get these questions because I owe you guys a long-awaited Q&A,

0:43 especially to all the people that submit questions to the Q & A box. So, just a reminder before I jump into these, if you have a question that you would like answered on a Q and A video, also sometimes if it's a good question, I will answer it in my emails that I send out to my email list, which you should sign up for. Don't forget there's a link to these wherever you're watching this video. Maybe it's YouTube. Probably not going to be YouTube at this point, but if it is on Spotify or iTunes, there is a Link in the description box to submit a question.

1:15 It's just called Hunter Williams video topic request. You can put it in there and I answer it on these Q&A videos. Sometimes if its a good one, I'll make a long form video about it. And usually what I'll do is if I get a lot of the same question, I will end up making a video of that. So thanks to you guys, i'm able to make some of best content because you submit the best questions. Without further ado, let's get into it. First question today, CJC1295Nodac took 300 micrograms my first night and got super flushed and raised heart rate.

1:48 Should I lower my dose to 200 micrograms for a while until I get used to coming off a broken tib fib six weeks post op on six Weeks of BTC. So yes, you should if 300 micro grams is too strong for you and you're getting flushing and raised heart rate That's very common with CJC. I would say that's not something that is out of the realm Possibility to happen. This is why I prefer people start with hip and relit in isolation But yes you go down even to like 150 micro-gram and your probably will notice that No side effects, or at the very least, less side-effects.

2:18 Moving along, next question. If I'm switching from Retatrutide to Terzapotide using HCG monotherapy along with Retajutride, best bang for overall wellness buck? RetabPC 157 TB500 NAD and what else? So, that's a great stack. If you're using HCG, it's great. It's better than nothing for testosterone, but you could use testosterone. Reta BPC-157-TB500-NAD. I would probably throw in MOTC just to help with mitochondrial health, just help insulin sensitivity, and especially if you are losing weight.

2:51 So that is the one other thing I'd throw into that stack, a very common pairing to see RETA, NAD, MotC, then Bpc-1507, TB500 for insulin It's a good question. Next question, what can help with my body relaxing? My body subconsciously contracts at times. It causes pain due to old PTSD. Is there a peptide that could help relax my nervous system? So the stock answer to this would be C-LINK. I would probably, in this case, I personally use like one milligram of C length.

3:22 Maybe you have to do that once or twice a day. You can inject it. I think that's the highest and best form of injecting or of using it would be to inject It so I would recommend C. Lank In fact in acetyl C like aminate is a little bit stronger and you could do a milligram of that So if there was a peptide, it will be that one, but that is probably a very complex issue I wouldn't guarantee that C length would help in that case. So next one I was wondering, next question, if you had any recommendations for a peptide to take to possibly help out with migraines.

3:54 My buddy has been having migraine trapele for years now and has tried pretty much everything. So again, migrain's pretty multifaceted. However, I would say I've heard of people taking like five to 10 milligrams of SS31 per day, which is higher than like the therapeutic dose of one to two milligrams. But five to 10 milligrams of SS 31 per day, I have heard of people saying it helped or even healed their migraines. Next question, can you take a GLP-1 and Tessmerelin at the same time?

4:26 Yes, I think you can and I should. I actually just wrote an email about this yesterday about how so many people are taking GLPs, but they never address their hormones. So I thing it's very important that we look at one, testosterone, two, growth hormone, and three, using something like a metformin or a Jardiens alongside a glp-one to really help accelerate the results. Yes you should and you could. Next question. Hi Hunter. My husband and I work out at night around 6 PM and we don't get home to have post-workout meal till 9 PM.

4:56 Would it be best to inject CJC if a blend before our workout or 30 minutes after a post workout meal is okay? So honestly, when it comes down to this, I would just say, if you're taking it, you going to be good. Yes, we can get in the nuances of like timing and insulin levels and everything to optimize it. So in this person's case, I'd probably say if they're going into the workout on an emptier stomach, so that maybe they haven't eaten in two or three hours, they could do it before the work out and be totally fine. I think you look at post-workout nutrition, it's very important to get the meal post workout.

5:31 And if you're eating at 9 p.m. And then trying to go to bed at like 10 10 30 pm might be hard to time that injection now if You're going to bet it like midnight after the workout because you are eating it night I think it's fine to take it at midnight before bed so those would be my two answers and You know you could do it before post workout the thing with the the growth hormone post growth on peptide post-workout is if we really are trying too get every last detail buttoned up. I think it's more important to have a meal post-workout than being on an empty stomach injecting your growth hormone peptide,

6:02 but you can do both. So let's see, next question. Have been microdosing GLP-3, aka Ritatrutide at 0.15 milligrams, But I'm so tired two full days after I take it and slightly depressed. Any ideas how to combat this? So first of all, I want to say obviously stock answer is going to be testosterone, right? If you have low hormone levels, You're probably going to feel depressed anyway, but the caloric deficit and increase in energy expenditure caused by the GLP-1 is not going lower testosterone levels.

6:32 It actually could probably help raise them, But we want to make sure we have a hormonal baseline that is supporting that. Now, the next thing, this is actually a pretty common thing to see with the glp-one to people who are super fatigued. I wouldn't say it's as common with retotrutide, but with semaglutide you do see quite a bit of depression among people when they're using it. So my answer to that would be one, you got to make sure you're supplementing with minerals, magnesium, taurine. That will help a lot in terms of the tiredness. Two, understand that even if you are leaner, which I don't know if this person is or not, when you are burning fat because retrotruchide is accelerating

7:08 fat loss, there are residual toxins that are coming off the fat that were still in your bloodstream. And so something like an injectable glutathione, thiamine-synophil-1, is going to help the immune system and help deliver, clear out those toxins. A lot of people start doing that and then the fatigue goes away. It also is something that you just have to kind of adjust to. So a lot of people are like, man, I'm so fatigued. Typically that will go away after like four to eight weeks after using it. And then they kind kick things back in the gear and they continue to get the benefits of the Red True Tide.

7:38 That would be my answer to fatigue on GLP-1s. There's a of other things. I actually have a video called how to deal with GLp-one fatigue or something like that, which I guess is not on YouTube now, but you can look at that Dropbox which is in link of all my emails. Next question. Read your article on audioimmune and GLP-1. I am the same boat as the person in your story. Tried every diet, drugs, fasting, testing. You can imagine nothing really works.

8:14 Stephanie Remke had said to hold off because it could dump too much into the system where you were already inflamed. Can you elaborate more on this? I don't know specifically about that. Stephanie is a doctor. So I'm sure she has a valid point there, but let's talk about the, the GLP-1 and autoimmune disease. So when we look at auto immune disease, a lot of times that comes from inflammation in the body. A lot, not all, But a of inflammation, in body comes From insulin resistance or poor insulin signaling overall in The body and so when We look At GLPs

8:47 once it's fixing this upstream insulin Resistance or Poor insulin signalling. which then downstream clears the inflammation, which is then down stream clears autoimmune disease. So to this person, maybe you're not overweight, but you have auto immune disease and I have seen time and time again that GLP ones actually heal auto-immune diseases because they fix the insulin resistance to which most people would say, well, if I'm not over weight, how do I insulin resistant? A lot of times like this, person that may be skinny fat where they have a lot inflammatory visceral fat on the body, they necessarily not are overweight or would be considered obese.

9:20 Moving along, next question. It seems like everyone I talk to is coming down with a flu, cold, and CVD. You know what that means. Any peptide recommendations I have on hand, I would say stock answer would be thymacinophil-1, LL-37 are really good to have there. I will also have thyma-gen or thylmalin. with an A, thymalin with a A. Those would be my go-to ones. Then you could throw in something like a BPC, TB 500 or KPV just to help with inflammation in the body. But thiamin-sulfo-1, really good start there.

9:52 Next question. Moving along, I'm a healthy 74 year young female that up until a year ago was very active. My basic panel was in normal range and not for no reason for the sudden lack of energy, achy joints and muscles, and sensitive stomach. I take no medications. And I am not overweight and focusing on that kind of peptide. Hypermellan has been a lifesaver so far, but need to find the next peptid when I break from Hypermelan to continue to improve my energy and overall health. So first thing I say to this person, that's out there, check your testosterone levels, get that looked at first.

10:25 And then I would probably for all of those things move to a GLP-1 because that kind of sounds like an autoimmune issue to me, kind sounds just like regular inflammation in the body. So say testosterone first and then GLp-one. Next one, is it okay to jump into a blend like Glow or Clo or any blend or should a trial be done on each peptide separately? separate product and pin each one, no mixing. If so, how long until you can try a blended peptide, a few pins, weeks or full cycle? So I will say, if you don't have experience with any of those peptides in isolation, which a lot of people don' t, maybe just do yourself a favor and test

11:00 them all first to see how you respond. Now in the Glow Blend or the Clow blend, you're probably going to be okay because almost all of those peptides, with the exception of the GHK, people respond very well to. It's just the ghk that makes it sting a little bit. So I always am of, the opinion when we look at the growth hormone peptide, so obviously try those in isolation because people for whatever reason love to jump to a blend. But when you look glow and clow, could you do those on isolation? Yeah, I would recommend it. If you are experienced and you use all them, there's no problem.

11:36 I think regarding that, the next part of their question was when first starting, is it recommended to titrate up the recommended optimal therapeutic dose or can you just start with a recommended dose? For example, recommendation on cheat sheet of SS31 is 500 micrograms AM five days on, two days off. Should a beginner start at 250 micro grams for a few days a week or titrated up to 500 micrograms? So in relation to the cheat sheets, for the most part, I have like starter doses on the cheatsheet for that. So I'd say you're good to start there. If it's on the cheat sheet, I almost always have like the beginner dose on there.

12:07 There's not anything I can think of off hand that I have, like a higher dose of on their. So as I started the dose, on a cheat, cheat and titrate up them there as needed. Here's a question, how to turn five milligram vial of saline in a nasal spray, use salin or deionized water to reconstitute how much per day for optimal effect. Is sub-Q better? Well, yes, sub Q is better. You can use Salin, or Deionize water. So if you go into Amazon and you just look for saling nasal, spray just a plain nasal Spray without any sort of other ingredients in it.

12:42 Instead of backwater, you would use that to mix into the vial, and then you would pull that back out and put it into nasal spray bottle and use that to do. So if you had a five milligram vile, you could add two mLs of the saline solution nasal-spray to the bile, pull it back, most nasal spayers spray 0.1 ml or 10 units. And so 0,1 ml or ten units in that case would be 250 micrograms. You could do one pump of that or one of them into each nostril.

13:12 There you go. Next question. I read your recent email blog about using metformin to control estrogen. First, if using Metformins, how long would you need to take it for? I would say in that case, probably at least four to six weeks before you would really notice a difference in the metabolization of testosterone and estrogen. Next question is of all the different companies out there offering biomarker test packages, would you recommend that provides the most useful information

13:43 for someone looking to optimize their health? Life Extension has a really good panel. It's just called the Male Elite Panel. PrivateMD Labs has really panels. You can get like elite panels on there. So I would say those two companies are really. Good. you can order a blood walker on your own. If you're in the United States, you don't need a doctor to do so. And you. Can interpret your. Own results or follow people like me that help teach other people how to interpret their results. Next question, GLP question.

14:14 Sorry, sometimes the grammar on this is not the best. I guess I think what they're trying to say is if you recomp your body and lost some weight on trisapatite that went down to maintenance to work more on muscle and you are ready to shred again, can you go up the dose again? Yes, you can in fact do that. So this is where I kind of tongue in cheek called blasting and cruising GLPs, but I think there's a use case throughout the year to use like a micro dose of a GLP. And then if you do want to, shred down quote unquote, You could use a higher dose and then go back down.

14:48 Yeah. I there was a case for blasting in cruising, GLPS for sure. Next question. just trying to read through to get to the question because some of these can get quite long, which I appreciate. Don't feel like you can't send long questions. It's just for the sake of content creation. Sometimes I have to distill them down. So this question just says, I went to another doctor who determined that I had posterior tibial tendonitis with a clasping arc. They recommend that. I do physical therapy. I've been doing PT two to three times a week for three months and I'm still swollen and so much pain.

15:18 They moved me to doing water therapy and walk in the water. I came across your page and started taking BPC and TB 500 for 3.5 weeks, now at 500 micrograms daily. Still a lot of pain, struggling to walk, taking hydrocodone, Tylenol daily, the doctor is now wanting to do a nerve block injection in my back with lidocaine to try and reset pain my pain arch to give me some relief from pain I am still dealing with a lof of swelling, please help. So in this case, BPC and TB 500 are good.

15:48 It probably is not going to be strong enough. I don't know if there's a structural issue there, but I would just add in cartilax. And I'd add KPB and see if that would help. So that really would be my only recommendation to that person. Sorry, just moving along. Some of these are not always questions, so it might take me a second to get through them. So here's a good one.

16:18 So I'm looking for another muscle builder that's not HGH to incorporate into my muscle building stack. Yes, IGF-1 is great. I think that's one of those things you could use it in conjunction with growth hormone. If you wanted to, you can use in the conjunction of growth hormones. Peptide, like Testimonelline, if you don't have to you, could be used in isolation. But I'd think a 4-6 week cycle of IGf, start with 50 micrograms and work up to 100 or 200 micro grams per day.

16:54 works great. So I really like IGF. It does seem to work well to put muscle on, but the only kicker is that when I've used it, like after four to six weeks, it seems to go down in effectiveness to what you'd probably need to up the dose. I just never did after getting to like the 250 ish to 300 micrograms per day dose, which I think is going to be like for most average people, not bodybuilders, for the most people. Uh, one of the, the higher end of range.

17:24 along. This is a good one. Does metformin reduce protein synthesis? I guess if you looked at it in a Petri dish, it would, and there are studies to say like, Oh, well, you're not going to be as effective. from a muscle standpoint or muscle repair standpoint when you're using metformin. But to that, I would also say we can still gain a lot of muscle and benefit a lots from taking met formin at the right dose. So I'd say one, it's dose dependent. And then also two, It's kind of like a catch 22 because we have this like longevity versus performance, right? And so if you were trying to max performance maybe met format isn't for you, but if we're trying max longevity, then met-formant is definitely for and

17:58 maybe maxing performance is not what you are working on. Maybe longevity is in that case, This is a good question I've talked about before. So someone says, I'd love to hear your take on SARMs. Why or why not should we use SARM? So SARMS are selective androgen receptor modulators. I'm not the biggest fan for a number of reasons. One, sometimes the quality is not what they say they are because some companies are Not completely honest in what they sell. The second reason is I think there's a lot better things out there than SARMs that we can use to get the intended effect that.

18:33 We have lots and lots of data behind, whereas SARMS, we don't have a lotta data. And lastly, I've just seen really bad results from people, whether it's like blood work or lipid panels or things like that, when they're using SARMS. And so the reason is I would like to, I wish I could sit here and tell you that SARMs were the future. I just don't think they are. Whether it's like anabolic steroids going down that path, there's things that we have access to that are way better, or it is peptides that have that way

19:03 are better. There's just better solutions. So that's why I don' quote unquote shill for SARms. This one I think would be a good question. It's about Enclomaphene. So they say, I just read your blog post on the test of lutein results and saw the increases in LH, FSH, and total test. I want to share results I've had within clomophene, 6.25 milligrams every other day for three to four months now. My total tests went from 430 to 754, L H from 3.1 to 4 and estradiol from 79 to 66. Prolactin six to seven, both stayed in normal range during this test.

19:39 What are your thoughts on Enclomapheme for increasing endogenous production of testosterone, but short-term and long-terms? So short term, I think it's okay. I'm not personally a fan of it, having used it in the past, and I had to do all of that before I started testosterone because my doctor wanted me to. However, in some cases, it is obviously better than nothing. And I do think some guys stand to benefit doing that, before they start testosterone just because it kind of like you have to go to high school before you go college. and do it. I don't think it's a long-term solution, though, and what we have seen is that there are certain side effects after long term use that are not good,

20:14 like blurred vision and things like that. So, I know that it is a short- term solution. Whether it was a PCT is okay, but longterm, definitely not. Next one, on the topic of bioregulators, what are the best stacks with injectable peptides? How to use 10 days versus 30 days. So for the injectable bioregulators, I like 30 to 60 days, that's kind of a loaded question. There's infinite number of permutations and combinations. I really like, guess I'll just say my favorite injectible bi-regulators. Cardilax is good.

20:44 Vessagen is Good. Velon is What else am I missing? Anything. And testigen would be good. So those would my top four. There's obviously much more, but I really like those because those are ones that you're going to feel more. Some of the other ones you are not just going feel like, you know, pineal on, maybe you feel it. I never really felt it, But I felt like I was healthier maybe versus the others ones. Like I definitely had a feel effect. Just my opinion. Talked about this one a lot, but just to sum up, you can go check out in an earlier video, I talked about combining NAD,

21:18 MOTC, and five amino one MQ and one vial. How long the vile of all three combined last, how safe is this? In my case has always been safe. Now full disclosure, i've never done a pharmacological or PK analysis on this, But it's always seemed to work for me when I've injected it and I run through the whole vials. So practice versus theory, This is a good one. I think since this question, I came out of the video, but next question was I stumbled onto this peptide that nobody's talking about. It beats up a talon for telomere repair and so many others that I can't believe it's seemingly being brushed aside.

21:52 That's called Vessagen. When you start digging in, as I have, you'll be amazed. If you can do a deep dive on it, and I thank your audience, then I will be grateful. And I almost didn't want to mention and keep this to myself, that so may people will benefit from this peptide, even if they ignore all others. Just something to investigate with this one also. Need to watch blood count as it does seem to lower hemoglobin levels slightly. Well, I think in some people's case, that might be a good thing, or they would think it would be good if they're hemoglobin and hematocrit or high from using testosterone. However, yes, did do a deep dive on Vestigen. Yes, it's an amazing peptide. If we look at overall health in the body, if we are improving endothelial health and the health of our blood vessels, is going to affect every other system

22:29 of body because obviously we have to get blood everywhere in our body. So, to that I would say yes Vesigin is amazing. It's a pretty cheap peptid. I'd say everyone should take it and yes I love it. They're right on the money with this one and I would recommend that you also maybe find yourself some Vessagen out there. Can you speak on taking peptides for heart issues such as blockage, if there's anything that actually helps, as well as taking TRT if you have those issues? I am 72 years old and not sure if VIP or a cardiogen helps with these type of issues. Well, yes, VIP and cardiogin would help with those.

23:00 I think Retatrutide would be more of an immediate source of relief. And then also too, I would get on Jardience, the data around Jartience which is an oral capsule or oral tablet, pharmaceutical drug. It's pretty profound when we look at the reduction in heart attacks for people that have had a heart attack. So future heart-attacks get dramatically reduced in people who have have heart atacks in the past when they're using Jardian. That's where I would also look.

23:30 This is a good one. I get asked a lot about this, so I'll say this even though I've made some statements about it. good job on you for doing so for learning about alternative because I know mainstream medicine is not always conducive to that. So my father-in-law is doing very, very well. He had an episode where he was hospitalized for COPD and he had I don't know if blockage is the right word.

24:04 He had like fluid on his lungs and stuff and he was in there for probably a week. probably about seven months ago now, six or seven month ago, now and he's doing totally fine. Has not had an issue. I think part of his problem was made worse by the fact that he works on a golf course. And he is not the most metabolicly healthy guy. He has a stent and, you know, he has had some issues in the past.

24:38 to the point the peptides have massively helped him he'll swear it up and down by that and maybe i'll get him on a show one day and we'll hash it out i think that would be funny and i Think a lot of people would actually like that because uh he's just a normal guy just like i'm a Here's a good one. I am 68 years old and have about 12 pounds I've been trying to lose for three years.

25:20 Yeah, I would even say red, red true tide and metformin and Jordians. I think in this case for someone would help for those like last 12 pounds that you're trying to do. So didn't have to be too hard. That's why there are miracle drugs for what they do so. Yeah. Someone else asked about my father and COPD treatment. hair growth and the best peptides for a woman in mid thirties who's losing hair. GHK is going to be the first one.

25:51 I will also ask every woman that are thirteens who is losing here to look at your thyroid. A lot of times that's when we'll see monumental declines in thyroid function. So just look in desiccated thyroid, there's also another peptide called AHK, A is an Apple HKCU that is from what I understand a modification of GH KCU did work better for hair loss. And I would check that out as well. Well, I don't know where to get it though or what the source is.

26:21 Here's a good one. How to recomp without adding too much fat for someone's skinny fat. So we see this a lot in people that are skinny-fat because they want to re-comp, meaning they basically want put on muscle and lose fat at the same time. I want to say this because people that are skinny fat don't think that they need to necessarily lose weight because they're skinny-fat, but you need lose the weight and you get the visceral fat off your body. So the first thing I would do is obviously get hormonally optimized, then I'd use Retatrutide, I'll use MOTC, and that would use maybe a little bit of

26:52 a growth hormone peptide like ipamrelin or testimrelon. And I will do that for 12 to 16 weeks consistently and see where it goes. The reason is because if you get the visceral fat off your body, now all of a sudden you have a clean slate to start building muscle, which you probably desperately need. The testosterone will help with that. So the point is like when people say re-comp, a lot of times what I hear is that it's not what they're saying, is I need to lose fat. And once you lose that, then you can start build muscle. You will always build the best muscle when you start really lean. And when you start from a place of being really lean, meaning there's no visceral fat on your body, then you can build a quality muscle and you're going

27:28 to look a lot better. So that would be my recommendation for that person. Just going through these, looking for some shorter questions. Views on Vilon's benefits. Is this a key peptide for longevity? Would you take it alongside epithelium and thymalin, or those who are already enough? I would take alongside it epitelian and thiolin. Now, Vylon is in thimalin.

27:58 So maybe that's a little bit redundant. But I think from an inflammation standpoint, I like to say BP, to me, vylon, is like taping from a feel standpoint. It's like taking BPC and themicin alpha one together. That's how it feels. And there's obviously like longevity benefits to it as well. I really like it from that standpoint What are your thoughts on testigen? I think testagen is great. I thing testogen might even be better than HCG at what it does. So I love testingen. And I thank every male. If you're not on testosterone therapy, you should try testegen.

28:29 and if you are on Testosterone therapy and you were concerned about fertility, I Think testigens is a great as well. Would testosterone to inject sub Q and dose for a six-year-old man that wants to switch from cream to injections? So I don't recommend injecting testosterone sub-Q. I know people will disagree with that. That's totally cool. If you like injectting testosterone, subQ, I think you should keep doing it. However, it's much better to do IM. And I also think that people shy away because they're scared of injections. and if that's the case, you get over having to injected intramuscularly because you stand to benefit a lot to gain.

29:05 from injecting intramuscularly. So in terms of the dose, I would start at 200 milligrams a week for a 60 year old man. I know some people think that's high, but I think you should start there and then titrate down or titrated up based on what you need. So I get this question asked a lot. Let's try to clear it up a little bit here. Example, if you are for research purposes taking Testigen, CJC, IPA, BPC-TB500, GHK, KPV, SS31, and MOTC. How many of these can be introduced through the same injection?

29:38 to which in that case, I would say BPC, TB, GHK, KPV, all good. The other ones, SS31, Mod C, CJC, IPA, Testogen, keep them out. So kind of think about that as pathways and those ones that I mentioned specifically are working more on inflammatory pathways. They're also commercially made in blends that for what we know seem to hold up pretty well. Those are the ones I'd be able to put in the same syringe out of that list.

30:10 Here's a good one, even though we're heading into the fall. So when we look at shipping peptides in the summer heat wave, do you need ice packs, shipping times, degradation without ice pack, et cetera? To be honest, I'm not super worried about those things. Now a chemist may say otherwise, but I have read papers where leaving peptide out at room temperature or even up to like 100, 110 degrees, most of the time they're gonna be fine. No, yes, if we can get up like 150, 170 degrees you're probably gonna run into issues. But I will say with the, in regards to the icepacks, If you have an ice pack in there and it's melted when it gets to your house,

30:44 it still did its job because it was cold when I left. So it kept it cold, you know, for two or three days until it got there. Like you cannot expect an Icepack to stay cold for 2 or 3 days in the heat, but it Kept it Cold for when It needed to be cold so that when you got in your House, You can put it in a refrigerator. Hopefully that makes sense. Here's a good one. I think the answer is easy too. So women going through menopause and their clitoris is shrinking, causing libido and sexual sensation to be non-existent.

31:14 Any help will be greatly appreciated. If you inject some testosterone or rub some testosterone cream on it, your problems will solve. That would be the first thing. And unfortunately we're still in a state of the world where that is not widely accepted as medical treatment. That would be my response to that one. How old do you need to be to take bioregulators? Would they be okay for high school athletes, kids with urinary problems? My opinion, I don't like to get into talking about stuff for kids, but I think everyone is safe to by regulators regardless of age.

31:47 So that would my recommendation. Here's a good question. I know you were a big fan of metformin.

32:22 Is there a peptide or bioregulator that can take to lower histamine or inflammatory reactions to other peptides? I think thiaminacin alpha-1 and KPV do this really well. So a lot of people have a histamine reaction to peptids. meaning that they break out in hives. They get flushing, they get an increased heart rate. A lot of times it's growth hormone peptides. In my experience, I'm not going to say this for everybody, but in my experienced the thiamin-synophil-1 and KPP do this really well. Honestly, even a little bit of a GLP does too. So microdoses of GLPs help calm that histamine response.

32:56 I think this is a good question. With the research companies adding more products in different quantities instead of five or 10 milligrams, some companies are offering vials in 20, 22, or even 40 milligrams. How do you reconstitute them? I've done the peptide calculator with these new amounts, but with a three ml vial with 22 milligrams of RETA, is this not diluted enough? Not sure how to operate with this new amount. So the question is like, you know, if you have like a 40 or 50 milligram vile of Reddit TrueType, let's see, If you put three mls of water, What does that make it? Well, if it's 50 milligrams, what would that be?

33:27 About 17 milligrams per milliliter. And so if you did 10 units, that would be 1.7 milligrams of red dust. For some people that might be too much per dose. Some people might need more than that. So the question is, well, one, If you don't want to do that, just buy a smaller amount. Two, you could get another vial and add like mix the water into the vial, take it out, put it into a new vile and then add more water to dilute it down more if you wanted to, if it's just a three ML vio.

33:57 And then also too, I would just say be smart about how you do it. So I realized like buying a bigger vyle probably saves you some money, but to the question of the effectiveness of a peptide, it doesn't really change. It's kind of one of those things like you're just, you know, its calories in calories out in terms of how we're mixing it and you are getting the same thing. Moving along, sorry, just scanning through these to make sure I get a good question.

34:30 Here's a great one. Can GLP-1s like trisapatite and retitrutide be okay to take with thymosanophil-I? Recommendations or cautions for stacking other peptides that can influence other major systems and pathways. So obviously I can't go into a thousand different peptide, but thimosalpha-one is completely okay. To take what the GLp- one and I would say even for people with autoimmune disease or a lot of inflammation would probably be advantageous and good to do so. Here's a good question. ATX 304, a company sent out a notification of availability of that. And I started to dig a little and it sounds very similar to Metformin, but possibly better.

35:02 What do you think? Yes, it is very much similar MetFormin. Yes. I think it's even better than MetFormin because it seems to help people lose more fat. Now a big question I'm getting is ATX 304 versus SLU PP332. The answer is fundamentally they're different, but fundamentally, they also kind of help get the same results that we're trying to get, which is fat loss. But SL U works on mitochondrial biogenesis. ATX304, well, SLU is an estrogen receptor, estrogen-related receptor agonist, which then helps with mitochondrial biogenesis,

35:38 whereas ATx30 is a AMPK activator. So it is more of a longevity compound, although it helps without loss. I would say AT-X is like an enhanced version of metformin, if you really look at it that way. Here's a good one. Can you add a category if you're using TURS and Reddit together? I'm taking eight milligrams of Turs, two shots of four milligrams Reddit.

36:14 And since adding red up, my appetite has really come back. So yes, you can add category to that. I would say the TURZ and red may be redundant together, but if you want to do Reddit and CAG or Turs and Cag, it could definitely do that less people need to TERS and category because Ters seems to have a stronger appetite suppressing effect. But nonetheless, You can definitely use them all together if You want it to. Next question, Hunter, I'm very interested in the protocols around transitioning off of turzapotide and step down titration strategies around that.

36:52 Also interested if one could jump to another like Reta or another peptide combination without risking the side effects or rebound weight gain. So a couple of answers to this. I like titrating down by like around 25% per week. So let's say you're on 10 milligrams of tersepside a week, which hopefully you aren't, but I would go from like seven point from 10 to 7.5 from 7 point five. Obviously this is not like exact math. 7.5 to 5, 5 to 2. 5 and then maybe 2 to 1, and 1 and off. So that gives you a 5-6 week period where you're tight trading down, still getting some of the effects, then you can come completely off,

37:27 go 4 to 6 or even 8 weeks off and build back up. What's really cool now is that we have access to Orforg Lepron, which is the small molecule GLP drug that works really well, in my experience. And so you could really just, I think, stop terse cold turkey if you wanted to, or at least titrate down pretty fast, and then use the OrForg lipron for four to eight weeks and get the same effect. You're going to have to figure out your dose of Or Forg Lipron. Is it six, is it 12, 24 milligrams? per day, but I really like that because we have access to it now.

37:57 So I would say that. But if you didn't have, or for Gleapron, you can definitely do that, I also like to, to kind of like, some people will say like mix the turrs with the Retta and like slowly bring down the turs and increase up the retta till you're like at just on Retha. I like the kind slowly titrate down with ters, get to like a really low dose or completely off of it and then start a low-dose of rett and build back up as we need. but that's just me. That's like what I'd like do. There's no right or wrong answer.

38:28 Let's see. My average blood sugar and healthy bloodsugar for all. So this is a good thing. I think I could talk about not super peptide related, but it's still related. When we look at blood, sugar, we have all these components. We have fasting glucose, hemoglobin A1C, and then we got fasting insulin. I personally like to look at fasting insulin more as a marker of how metabolically healthy I am than fasting glucose. Fasting glucose can be transiently raised, it can transientally be low, but a lot of times it's not the best indicator of metabolical healthy we are.

39:06 Now it is still worth looking at. So my fasting glucose is usually somewhere around like 84 to 90 depending on the day, depending how much I slept, depends on stress, you know, or whatever. Is that good? You know, some people would say like, oh, it needs to be like 75, you know? Some people are like that's fine if it's like 105. I would like to see it at 105, but sometimes I'm sure mine is that high. If I got it tested, because you may have had a cheat meal the night before, or I may not have slept well or been super stressed out. So there's no right answer, but what I do like to see is a single digit fasting insulin number.

39:40 To me, that's a much better indicator of metabolic health. So if you're fasting, insulin is below 10. That's really good. Ideally, it's below five if he wanted to be like super anal or tentative. The A1C is also important, but that can also have some weird things where it's like artificially high or not the best indicator of stuff. Usually my A 1C, is like a five two or five three, so not like super low, But also my fasting insulin will be superlow. So like I lean on that more, if that makes sense. I think fasting, insulin is the better indicator, of our insulin health.

40:11 Because what that tells me is how much insulin, the pancreas pumping out to keep our blood sugar down. And if that number is low and your blood sugar is also relatively in range, then you're good. But if your fasting insulin is 25 to get your Blood Sugar down to 85 or 90, that's not good, That means the pancreas have to work really hard and that is where you will eventually become diabetic. My testosterone, next question, my testosterone was low. So my endocrinologist prescribed a cream of testosterone with estrogen.

40:44 I immediately felt better, but my hair started falling out. no sex drive, motivation, apathy, et cetera. Please help. Well, I would switch to injectable testosterone and I will also get on desiccated thyroid. The reason that most people start having their hair fall out with testosterone cream is because it does spike DHT more, which does accelerate people that are predisposed to go bald. So in that case, injectible testosterone at a low dose, maybe a five to 10 milligrams per week will be your friend and will most likely not cause the same

41:16 amount of hair loss. Here's a good one. Next question. I am 60 and in great physical condition, but I'm feeling joint pain, slow recovery, post-workout, and my chest does not firm up no matter how hard I work it. Considering pep pads, I'd like to get your perspective on the use of that at 60 plus years old. Well, to this person, first of all, sounds like you have a testosterone deficiency. If this is a man, they're talking about their chest muscles. Almost without a doubt you have a low testosterone so I would start there first then I either go to growth hormone or a growth hormonal peptide Then I

41:50 use a micro dose of GLP-1 and especially for this person with joints and issues recovering You know BPC and TB 500 are going to work really really well for someone that's never done that especially if they're just getting started in peptides So it's kind of funny because like people in the peptid world I think a lot of times we overlook BPC and TB 500 because there's like, oh, what's the next thing? We get shiny object syndrome and we're like what the the thing. But it's people that have never been exposed to these, they can be absolutely life changing. And they're so basic and simple and relatively affordable. So next question, can I take bronchogen with retitrutide?

42:22 Yes, you can. I just would not put them in the same syringe. You know, until I talked about the COPD that my father-in-law have, and maybe it's just because I've talked it and there's other stuff like this that people don't reach out to me for, I got a lot of people reach to out me about lung issues. So that's one of those things, like, if one person has it, then I know like probably 10,000 people have it. And if 10 people, probably like 100,00 people out there are suffering from it so I can't stress how important it is to get these questions for you guys, for me, in terms of content creation because it helps me so much to make really good content.

42:53 best fat loss, recon peptide for athletes, specifically endurance athletes who still need to adequately fuel himself, had horrible reactions to testosterone and only has five to 10% stubborn fat to lose. In that case, I would say probably a microdose of a GLP one is going to be good. It's not going performance from that sense. I think something like a carterine would work really well for a person like this. It helps with endurance. Something like an SLUPP332 would help a lot with this, especially if they're active like that. And obviously to just make sure your hormones are optimized.

43:25 That's like beating a dead horse. If you've been listening, you know, 43 minutes in now, but for endurance athletes, that's really important because the stress that the body incurs in doing endurance activity, it wrecks your endocrine system. So, Here's a comparison one. So pineal on cortigen and vestigen together versus cerebral isin and cortex. And I would say probably, so they're basically saying like synthetics by regulators versus the pig, which cerebralizing comes from pig brains,

43:57 cortex, and I believe does too. and so I. Would say in the case of like Alzheimer's dementia, probably cerebralized in, I was saying in case like optimization, The synthetics are probably going to be better just to like be able to run more often. I don't think you need to use cerebral isin more than once or twice per year if you're just trying to Be as healthy as possible. So here's a good one to which I, I Don't really know the answer, but I can give you my opinion on it. Someone says, can you talk about peptides for MTHFR gene mutations?

44:27 I think and this may upset some people, and I'm sorry if it does, I don't think it matters. So I think there's any peptides that you can or can't take if you have the MTFHR gene mutation. I dunno, what is it, like 40% of people have this gene mutations? So it's kinda like saying if have brown hair, you cant do something. And I dont think anyone would say that, meaning that I Genes have a place and understanding our genes have place.

44:57 But I think when we talk about this, it's like people think that because if they have the empty FHR gene that they can't do something to which it is more our genetic code is less relevant than what we are signaling to our And yeah, there may be some supplements that work better. You know, like maybe you need a little bit more B12 or methylcobalamin if you have the MTFHR gene. But in my experience, I've never seen one peptide that I said, Oh, this person had MFH is not going to be good. Now, someone could disagree with me. Someone a lot smarter than me could just agree with and that's totally cool.

45:29 But that is just my practical experience. And I think when we get into that, it's a slippery slope because we start trying to do all this stuff and we forget the leading indicators, which are, what are my inputs? What's my diet? what's, my training, What is my lifestyle? Someone says, hi, I listened to your podcast on women's testosterone, but you didn't specify what a good level is. I started injections in my levels at 215. Now is that too high?

46:00 I don't think it's too. Hi, the free testosterone is much more important. So if your free, testosterone it is between like five and 10 as a woman, you're good. But in order to get there, your total may need to be four or 500 and that's totally okay. Good luck finding a doctor that will tell you that. And again, doctors aren't bad people, but they just a lot of times will treat the reference ranges. The best weight loss, GLP, drug? Well, I would say retitrutide. That would be the simple answer.

46:30 However, there's more things coming down the pipe, and Orphoraglipron, in terms of appetite suppression, may even be a little bit better than retritrutite. I don't think the fat loss from Orphoraglibron is as good as the Fat Loss from retrutitide, but I think you could combine them both. So even though retretrutate would the the answer, There's some stuff coming that's going to be good. We have bioglutide which is basically retutite plus an IGF agonism. There's a lot of stuff out there that I think is going to be beneficial coming down the road.

47:03 Do GOP1s have any positive benefits for perimenopausal women? Any benefits to help balance or promote hormones? So they do in terms of insulin resistance and metabolic health, they absolutely can help permenopause women. And we see that. However, what are perimentoposal woman lacking that is causing insulin resistance a lot of times that they would have not experienced before earlier in life. Well, that's a deficiency in testosterone and sometimes a efficiency in estrogen and oftentimes a deficiencies in progesterone. So what can we do if we pair bioidentical hormones with GLPs?

47:36 It is the Holy Grail. Undisputed Holy grail of health is using GLP's with bio-identic hormones. Hopefully we can move the world in terms of how many people understand that out there. This person wants to know about my experience stacking Truze Appasite and Retta Truetide, effective dosage and protocol. I, you know, if I'm doing it, I like a one-to-one ratio. So the highest I think I ever got was like one and a half milligrams of both. One and half milligram of Trues, one milligram to Retto. And I really like that because you do have great appasites suppression, but you get like, that accelerated fat loss from Reto.

48:10 It's not a common thing to do now, because people like just hop on Rettrutide and it is so great. It really is. But I think there's a place for that, especially if people are struggling with appetite. This is a long question, but I it'll be a good one as we're getting here towards the end. So my question is about the daily timing of all these peptides and supplements. It's beginning to feel a little overwhelming with alarms going off on my phone. For reference, I'm a fit and active 56-year-old woman who is trying to body recomp and lose about 10 more pounds.

48:44 In addition to the 77 pounds I've lost over the past 18 months, I'm on a weekly estradiol patch, weekly sub-Q TRT, and nightly progesterone and magnesium. I also take T3 in the morning and mid-afternoon. Essential amino acids AMMPM with SLU PP332 at lunch. Also weekly RETTA. Like once a week so I can enjoy a slightly more normal weekend of food consumption. Reasonable point there, as an aside before I continue with the rest of the question, That's a good point. If you want to not feel so much appetite suppression on the weekend, maybe you're like going to have a cheat meal or a family reunion or something like that.

49:17 I think it's perfectly reasonable to like one or two doses of Reda so that you like are not so suppressed on a weekend. You can enjoy it and then go back to doing it. So anyway, just food for thought. I recently added AOD 9604, first thing in the morning, a test morel in evening, along with a variety of vitamin supplements that are supposed to be taken either fast or with food, depending on the type. How much time do you actually wait after, say, injecting AAD before taking other supplements in AM? I wanted to get as much efficacy out of all these items, but there's only so much on in morning. Thanks so any fasted state supplements with your AOD.

49:50 Meaning, the way I kind of set up my morning supplements, especially if like I'm eating breakfast, if I am not fasting that day, is I will take my supplements. I'll take me peptides and then I wait and take more of like my fat soluble supplements which will be my vitamins and my omega-3s and digestive enzymes and glutamine with my first meal. And so I'm getting that with food, but then my other supplements, you know, like my probiotic, my thyroid, I take those first thing in the morning.

50:20 My majority ends. What else? I was thinking offhand, carnitine, taurine. Those are fine to take in a fasted state. So I'd take this first in morning and I can take my peptides with that. No issue. Hopefully that helps answer the question. Next question, I want to ask if it's possible to combine SS31, AOD9604, and MOTC all into one syringe, like 33 units of each for one full ML. I hate to stick myself three times a day for three days a week, plus I am on 10 milligrams of red once a month.

50:51 My goal is to lose about 80 pounds and keep my muscle. Also taking GPL-MAN by regulator, SOU, PP332, 5-amino-1MQ. Unfortunately, my recommendation would be to not mix those. If you had to mix two, I would probably do SS31 and MOTC, but even then I keep them separate. But I definitely would not mix those with AOD as that is a growth hormone peptide. And just based on my experience, those do not play well together. So that'd be my recommendation. I have a bladder issue or issue of bladder infections.

51:22 They keep coming back and rehabilitating where I can't do anything. Help would be great. I need desperately fix the issue. So one for infections, I would say LL 37 is a good start. Thomasinophil one would also be helpful for. Infections. There's also a peptide called Vesalute, V-E-S-I-L-U-T- E. And when you pair that with Prosimax, it works really well on the prostate and the bladder. But in the case of this person, if they need help with their bladder, basically works to signal a more youthful state in the bladder specifically. So I would check that one out.

51:54 Next question, based on your last deep dive on retatrutide, do you still think there's potential to see muscle growth benefits from using it if said person was consistent with diet and exercise? Absolutely. I think if you are eating the right amount of carbs, you're taking a dose of retratrutite that does not inhibit your appetite too much, and you were training, your doing everything right from a diet standpoint, a training standpoint. Absolutely, RETA at a low dose works as the best nutrient partitioner of all time. And it also helps keep inflammation down and part of the problem in the muscle building world, It's like we accrue this oxidative stress through everything

52:29 we do to build muscle. And it's like we're Robin Peter to pay Paul, Robin Paul to Pay Peter, because we accrue this oxidative stress to get the muscle, which is our metabolic currency. And if we recruit the muscles, then that helps us long-term. But then we have this short- term oxidate of stress that we come through like eating and training. It's, like, so how do we minimize that? Well, Reddit True Tide really helps. Because we can do the eating, we could do that the training, and Reddit true tide is going to help minimize the oxidant stress based on everything that it is doing with improving insulin signaling in the body.

53:00 And so in short term, we're mitigating that oxidative stress. In the long term we are getting muscle and so we getting like a double benefit in a long-term for our metabolic health because we have more muscle now and we stop usually the oxidate stress that comes from occurring muscle. It's kind of funny because in order to put on muscle you have to eat in caloric surplus. Well, there's a consequence of that in body Kind of the same thing. You have to train hard. Well, there's a consequence of that in the body. And yes, we can manage those consequences. But what I'm saying is that Retro Tide works so well if we're using it in context of doing what we are doing, which is talking about building muscle here.

53:36 So I love that. I think, you know, it really is a great question. Next question, men over 55, will peptides make their pituitary glands produce the needed HGH? It depends. So in some cases, yes, but in cases no. And a lot of that has to do with the downstream effects of just not metabolizing things the way that you would have when you were younger. I will say the gold standard, if someone is over fifty-five, is going to be chrysanthemum.

54:08 That doesn't mean that they can't benefit from Ipamerelin or Tessamerelin or CJC or Ceramorelin, or Hexarelin. Or whatever other one is out there, but human growth hormone do better. And I think it's even, there's a use case. I don't talk about this a lot. If you want to use growth for one eight to nine months out of the year and then use a peptide two to three months of a year, I'd think you'd definitely do that. Nothing you could benefit. So at the end of day, the answer most of times is going to be no, it is not going be as good as growth. But it still better than nothing.

54:39 Here's a good one. When women over 55 cannot lose weight regardless of lower carbs and calories, increasing protein, no appetite and working out three times a week, what is a healthy solution? Get your hormones checked because if someone is over fifty five and they're experiencing those things, it's because especially a woman, they do not have testosterone. They most likely do now have estrogen and a most like we do know how progesterone in their body. So I would get those checked out. Unfortunately, hundreds of million of women are suffering from that very thing right now. My heart goes out to them.

55:11 Here's a pet related question. So this person says, I have a dog and a cat. They are both one year old. Dog suffers from sudden panic attacks lasting over an hour or more, usually at night. No noises are going on. I've gone to several specialists and no one sees a problem, just a little elevated liver enzyme, not related to anxiety. Why no-one talks about peptides for my little one. Dosage according to size, and I'm sure there are lots of people who must be interested. So yeah, in this case I would say, BPC would do good. If it's caused by inflammation, TPC and TB 500 would just be good in general. And then you could give them some saline, so you can inject them with some Saline.

55:43 Full disclosure, I inject my dogs with a hundred million. There are two male dogs. I injected them. One is nine and one is 12. So they are older. They are German shepherds and I injection them with 100 milligrams of testosterone every 10 to 14 days. It has extended their life. Is extended. Their quality of life, there's no reason that the 12 year old really should be alive given that he's had four leg surgeries at this point. And he also was suffering from pretty bad dementia before I started doing that. Now his dementia is pretty much non-existent. He acts like a puppy. whether that's a good thing or a bad thing.

56:15 Sometimes in my case, it's like we have this 12 year old dog and he's acting like a puppy, but I would much rather him obviously act like that than the reverse, which is that dementia. Cause that really sad to see and witness your dog experience. But yeah, sometimes I'm amazed from doing that, how healthy our dogs are for their age, especially German shepherds typically don't live past nine or 10 years old. So moving along, required supplements while using TRT like magnesium.

56:46 I would say magnesium is obviously a required supplement. And I think desiccated thyroid should be a requirement. Supplement. Those are the two real things that I'd think you would have to say you have like go above and beyond on TRD. But, um, yeah, I just, when you look at it, your metabolism is going to be higher. You're going. To be depleting minerals at a faster rate. So magnesium and electrolytes are really important to have on testosterone. Desiccated thyroid, obviously very important. And I think metformin or berberine or Jardians, whatever you want to use, or all three of those would be really good.

57:25 Here's a good one as we get to a close. So Sarah Morellen, I know you were not impressed by this peptide, but getting emails about its benefits on brain health, and I'm not finding much info about it yet, except you said it's not worth it. Is it worth a closer look, or is Tessmorellen or one of the others related to this better choice? So at the end of day, Tessa Morell and Empermerellen and even CJC, even Hexterellin, are going to be better than Sarahmorelln. SarahMorellon is better nothing. I think people get mad that I don't have Sarah Marrone on the cheat sheet or I really don' talk about it. And it's kind of like one of those things that we just have so many better other things out there to use.

58:00 That's why I didn't really talk. Now I understand why it is even in the mainstream conscious now. And that's because clinics will prescribe it to people. Cause at one point it was FDA approved. I'm just not a fan. Now that doesn't mean you can't use it. If you want to use 200 micrograms of sirmorelin every night or five nights a week, that totally fine. People will sell that to you and you might love it! I've heard people literally tell me like, I love sir morelin. Why don't you talk about it? I'm like, well, obviously it's better than nothing, but there's so many things out there that are better to get the same effect. And for the cost, they're the.

58:31 So if you have something better, it costs the, and you get it as easy, why would you not use it? So that's my thinking on it. But Hey, if want the dose is 200, you know, 200 or 250 micrograms usually will be enough for people to, hopefully feel an effect, so. I think we will, Close down with this one. Can Tessmorelin cause cramping? I don't usually get muscle cramps. A hydrate regulator with electrolytes, I started taking Tessa Morelin dose of 10 units from a six milligram vial with two miles of water.

59:05 I start to experiment, experience the crams after three days and taking a dose per day. So yes, you definitely could. Typically, that's not something you see, but Tessmorelin does increase your metabolism, which will deplete minerals at a faster rate. So you are seeing the body have kind of like a new baseline metabolism which we'll de-pleat minerals faster. Now, most people on growth hormone peptides, even like Tessa Morelin, they'll notice like, a little bit of water retention,

59:37 But you still could get cramping. Definitely is a possibility. I would just say, hydrate, hydro-hydrate. Maybe take down the dose. you know, if they were doing this, this is 300 micrograms. So it's not a big dose, but for some people, depending on their body size and everything, it just might be it. The answer is you definitely can. It's more rare that you would see that. However, nonetheless, I would say like, you try other things, try taking down the dose and see where you're at. And obviously too, magnesium is your friend, taurine is friend electrolytes are your friends.

1:00:07 That will put us right at an hour. I hope you guys enjoyed this one. I think I got through a good chunk of these, maybe half of the 50 some odd pages that I had to do. So we will put a fork in this one. Hopefully you'd enjoyed this. And if you send a question, hopefully it got answered in there. I appreciate you guys really. Can't tell you how valuable this is to have this information from you to help create my content. Pretty much all the content I create now is based on what I hear from people. Obviously these things that I'm studying on my own, but it just gets so much better the more feedback I get from you guys.

1:00:41 So whether that's comments, obviously leaving a question in the question box, being on the email list, sending me emails and messages. I do my best to read those. Instagram is really hard to get back the messages because I got so many. But anyway, I appreciate you, guys, from the bottom of my heart. Thank you so, so I have the best audience in world, hands down, undisputed. Truly, if I get to spend my time doing anything, it would be this. So thank you guys so much. That's it for this one. And without any other further words, I will talk to you in the next one, peace.